FN Clarivate Analytics Web of Science VR 1.0 PT J AU Williams, GM Hoedt, EC Duncanson, K Gan, LY Prakoso, E Talley, NJ Beck, EJ AF Williams, Georgina M. Hoedt, Emily C. Duncanson, Kerith Gan, Lay Prakoso, Emilia Talley, Nicholas J. Beck, Eleanor J. TI Inverse associations between Mediterranean diet constituents and the gut microbiota in metabolic-associated steatotic liver disease (MASLD): a case-control study SO NUTRITION & METABOLISM LA English DT Article DE Microbiota; Microbiome; MAFLD; MASLD; NAFLD; Diet; Mediterranean diet ID NAFLD FIBROSIS SCORE; PRACTICE GUIDANCE; MANAGEMENT; DATABASE; INDEXES; FIB-4 AB Background Dietary therapy, specifically for weight loss, is currently considered first-line therapy for metabolic-associated steatotic liver disease (MASLD). However, increasing recognition of the role of the gut-liver axis in MASLD highlights potential for microbiota-modulating dietary therapy to improve outcomes. This study aimed to explore dietary variables relevant to gut microbiota in MASLD. Methods Twenty-five adults with MASLD and 25 healthy controls were recruited using a retrospective case-control design and characterised using 3-day dietary intake records, clinical markers, and shotgun metagenomic sequencing. Results MASLD participants consumed less dietary fibre (p = < 0.01), very long chain omega-3 fatty acids (p = 0.02), nuts and seeds (p = 0.03), whole grains (p < 0.01) and vegetables (p = 0.04). Participants with MASLD had lower abundance of Alistipes senegalensis (r=-0.01, p = 0.04), Coprococcus eutactus (r=-0.07, p = 0.006), Faecalibacterium (r=-0.02, p < 0.001), and higher abundance of Ruminococcus torques (r = 0.04, p = 0.02), and less expression of functional pathways associated with ethanol production, methionine, folate and branched-chain amino acid metabolism. Bacterial species and functional pathways more abundant in MASLD were positively associated with intake of added sugars and saturated fat, and negatively associated with unsaturated fatty acid and dietary fibre intake. Conclusions Microbiota characteristics differ between individuals with and without MASLD, and this is influenced by dietary intake. Future translation-focused research investigating dietary interventions and the gut-liver-axis in MASLD are warranted. C1 [Williams, Georgina M.; Hoedt, Emily C.; Duncanson, Kerith; Talley, Nicholas J.] Univ Newcastle, Coll Hlth Med & Wellbeing, Callaghan, NSW, Australia. [Williams, Georgina M.; Hoedt, Emily C.; Duncanson, Kerith; Talley, Nicholas J.] Univ Newcastle, NHMRC Ctr Res Excellence Digest Hlth, Newcastle, NSW, Australia. [Williams, Georgina M.; Hoedt, Emily C.; Duncanson, Kerith; Talley, Nicholas J.] Hunter Med Res Inst, New Lambton Hts, NSW, Australia. [Beck, Eleanor J.] Univ New South Wales, Sch Hlth Sci, Sydney, NSW, Australia. [Gan, Lay] John Hunter Hosp, Dept Gastroenterol, New Lambton Hts, NSW, Australia. [Prakoso, Emilia] Univ Sydney, Sydney Med Sch, Fac Med & Hlth, Sydney, Australia. [Prakoso, Emilia] Liverpool Hosp, Dept Gastroenterol & Liver, Sydney, NSW, Australia. [Prakoso, Emilia] Royal Prince Alfred Hosp, AW Morrow Gastroenterol & Liver Ctr, Sydney, NSW, Australia. [Williams, Georgina M.] Hunter Med Res Inst, Lot 1 Kookaburra Cct, New Lambton Hts, NSW 2305, Australia. C3 University of Newcastle; University of Newcastle; Hunter Medical Research Institute; University of Newcastle; University of New South Wales Sydney; John Hunter Hospital; University of Sydney; Liverpool Hospital; University of Sydney; NSW Health; Royal Prince Alfred Hospital; Hunter Medical Research Institute; University of Newcastle RP Williams, GM (通讯作者)，Univ Newcastle, Coll Hlth Med & Wellbeing, Callaghan, NSW, Australia.; Williams, GM (通讯作者)，Univ Newcastle, NHMRC Ctr Res Excellence Digest Hlth, Newcastle, NSW, Australia.; Williams, GM (通讯作者)，Hunter Med Res Inst, New Lambton Hts, NSW, Australia.; Williams, GM (通讯作者)，Hunter Med Res Inst, Lot 1 Kookaburra Cct, New Lambton Hts, NSW 2305, Australia. EM georgina.williams@newcastle.edu.au RI Hoedt, Emily/AAT-7016-2021; Williams, Georgina/KCY-8039-2024 FU NUW Alliance Grant FX This research was funded by NUW Alliance Grant, awarded 2019. 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Metab. PD DEC 23 PY 2025 VL 23 IS 1 AR 8 DI 10.1186/s12986-025-00939-8 PG 16 WC Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Nutrition & Dietetics GA CD5AK UT WOS:001663185600001 PM 41430289 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Canivet, CM Faure, S AF Canivet, C. M. Faure, S. TI Diagnosis and evaluation of metabolic dysfunction associated steatotic liver disease (MASLD) SO REVUE DE MEDECINE INTERNE LA English DT Article DE NAFLD; MASLD; Liver fibrosis; Non-invasive liver fibrosis test; Metabolic syndrome; Cirrhosis ID NONALCOHOLIC STEATOHEPATITIS; PRACTICE GUIDANCE; RISK-FACTORS; VITAMIN-E; FIBROSIS; NAFLD; MANAGEMENT; OUTCOMES; PLACEBO; SYSTEM AB Non-alcoholic fatty liver disease (NAFLD) or recently called Metabolic Dysfunction Associated Steatotic Liver Disease (MASLD), is the leading cause of liver disease, with an estimated worldwide prevalence of 25%. MASLD is suspected, in a metabolic condition, in the presence of hepatic steatosis, moderate hepatic cytolysis or hyperferritinemia. The severity of the disease depends on the stage of liver fibrosis, which can be suspected in clinical practice by simple blood tests such as the FIB -4 or NAFLD fibrosis Score. The treatment is based on lifestyle intervention combining weight loss, increased physical activity and a Mediterranean -style diet. Only a small minority of patients with MASLD will develop advanced liver disease and require liver specialist. Given the high prevalence of MASLD, the identification of these patients cannot be envisaged without the taking part in the screening of all physicians (general practitioners and specialists). (c) 2023 Societe Nationale Franc,aise de Medecine Interne (SNFMI). Published by Elsevier Masson SAS. All rights reserved. C1 [Canivet, C. M.] CHU Angers, Serv Hepatogastroenterol & Oncol Digest, Angers, France. [Canivet, C. 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Med. Interne PD JAN PY 2024 VL 45 IS 1 BP 41 EP 47 DI 10.1016/j.revmed.2023.10.438 EA JAN 2024 PG 7 WC Medicine, General & Internal WE Science Citation Index Expanded (SCI-EXPANDED) SC General & Internal Medicine GA HW8N3 UT WOS:001162639600001 PM 38158295 DA 2026-02-02 ER PT J AU Segala, A Vezzoli, M Vetturi, A Garrafa, E Zanini, B Bottani, E Marullo, M Marconi, S Ricci, C Valerio, A AF Segala, Agnese Vezzoli, Marika Vetturi, Alice Garrafa, Emirena Zanini, Barbara Bottani, Emanuela Marullo, Monica Marconi, Silvia Ricci, Chiara Valerio, Alessandra TI A Mediterranean Diet-Oriented Intervention Rescues Impaired Blood Cell Bioenergetics in Patients with Metabolic Dysfunction-Associated Steatotic Liver Disease SO DIAGNOSTICS LA English DT Article DE metabolic dysfunction-associated steatotic liver disease; Mediterranean diet; mitochondrial bioenergetics; peripheral blood mononuclear cells; descriptive statistics AB Background: Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD), a novel term for Non-Alcoholic Fatty Liver Disease (NAFLD), is associated with liver mitochondrial dysfunction. We previously demonstrated that mitochondrial respiratory capacity in peripheral blood mononuclear cells (PBMCs) was significantly reduced in patients with MASLD compared to non-MASLD controls. For MASLD treatment, guidelines recommend behavioral and dietary changes to reduce body weight. A recent 12-month clinical trial demonstrated that ameliorating patients' lifestyles through improved adherence to the Mediterranean diet and encouraged physical activity results in MASLD remission or regression. Methods: As a sub-study of the 12-month clinical trial, we evaluated the effects of the Mediterranean diet-oriented intervention on PBMC mitochondrial DNA content and respiratory parameters and on various biomarkers associated with MASLD. Results: Contrary to what was found at the baseline, after twelve months of intervention, systemic inflammatory and bioenergetics parameters did not differ between MASLD patients (N = 15) and control subjects (N = 17). PBMCs from MASLD subjects showed rescued basal respiration, ATP-linked respiration, maximal respiration, and spare respiratory capacity. The observed recovery coincided with a significant increase in the patients' adherence to the Mediterranean diet (Medscore). Conclusions: Our findings indicate that a Mediterranean diet-oriented intervention, without calorie reduction, preserves blood cell mitochondrial function in MASLD subjects. Thus, PBMC bioenergetics-based assays might be taken into account not only for diagnosing but also for monitoring therapeutic responses in MASLD. C1 [Segala, Agnese; Vezzoli, Marika; Vetturi, Alice; Garrafa, Emirena; Bottani, Emanuela; Valerio, Alessandra] Univ Brescia, Dept Mol & Translat Med, I-25123 Brescia, Italy. [Garrafa, Emirena] ASST Spedali Civili, Dept Lab Diagnost, I-25123 Brescia, Italy. [Zanini, Barbara; Marullo, Monica; Marconi, Silvia; Ricci, Chiara] Univ Brescia, Dept Clin & Expt Sci, I-25123 Brescia, Italy. [Ricci, Chiara] ASST Spedali Civili, Div Gastroenterol, I-25123 Brescia, Italy. [Bottani, Emanuela] Univ Verona, Dept Diagnost & Publ Hlth, Sect Pharmacol, I-37134 Verona, Italy. C3 University of Brescia; Hospital Spedali Civili Brescia; University of Brescia; Hospital Spedali Civili Brescia; University of Verona RP Valerio, A (通讯作者)，Univ Brescia, Dept Mol & Translat Med, I-25123 Brescia, Italy. EM agnese.segala@unibs.it; marika.vezzoli@unibs.it; alice.vetturi@unibs.it; emirena.garrafa@unibs.it; barbara.zanini@unibs.it; emanuela.bottani@univr.it; monica.marullo@unibs.it; silvia.marconi@unibs.it; chiara.ricci@unibs.it; alessandra.valerio@unibs.it RI Bottani, Emanuela/X-1778-2019; Vezzoli, Marika/AFQ-4217-2022; Valerio, Alessana/B-3413-2009; Marconi, Silvia/GSI-5324-2022 OI Bottani, Emanuela/0000-0003-1217-8722; Vezzoli, Marika/0000-0002-0424-4235; Valerio, Alessana/0000-0001-5844-2256; ricci, chiara/0000-0002-0748-6600; Marconi, Silvia/0000-0003-0464-8624; Segala, Agnese/0000-0002-9744-4681; Zanini, Barbara/0000-0002-1733-9938 FU University of Brescia, Health Wealth Call [HW_SEELN]; University of Brescia; Professional Dietetics S.p.A. (Milan, Italy); Fondazione Umberto Veronesi FX This research was funded by the University of Brescia, Health & Wealth Call, 2015 (#HW_SEELN project) to C. Ricci and A. Valerio. The SEELN project was co-funded by Professional Dietetics S.p.A. (Milan, Italy). E.B. was supported by Fondazione Umberto Veronesi. 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There are multiple treatment strategies proposed for pediatric MASLD, with lifestyle modifications and a balanced dietary regimen - particularly the Mediterranean diet in combination with weight loss, when needed - currently representing the cornerstone of clinical management. Behavioral psychological interventions are gaining increasing importance particularly in addressing comorbid eating disorders and supporting long-term adherence to therapeutic regimens. In addition, in daily clinical practice, the use of food supplements with antioxidant and hepatocyte anti-inflammatory effects is indicated in more advanced stages of steatosis, with the aim of limiting disease progression toward high-grade fibrosis and/or cirrhosis. This review aims to summarize current behavioral and nutritional therapeutic approaches for the management of pediatric MASLD. C1 [Mosca, Antonella; Pietrobattista, Andrea] Bambino Gesu Pediat Hosp, IRCCS, Unit Hepatol & Transplant Clin, Rome, Italy. [Braghini, Maria Rita; Alisi, Anna] Bambino Gesu Pediat Hosp, IRCCS, Res Unit Genet Complex Phenotypes, Rome, Italy. C3 IRCCS Bambino Gesu; IRCCS Bambino Gesu RP Mosca, A (通讯作者)，Bambino Gesu Pediat Hosp, IRCCS, Unit Hepatol & Transplant Clin, Rome, Italy. EM antonella.mosca@opbg.net RI mosca, antonella/JTS-6893-2023; Braghini, Maria/AAI-2070-2019; Alisi, Anna/A-6469-2010 FU Italian Ministry of Health with "Current Research funds FX The author(s) declare that financial support was received for the research and/or publication of this article. This research was funded by the Italian Ministry of Health with "Current Research funds" to Anna Alisi. 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TI Impact of Weight Loss on Metabolic Dysfunction Associated Steatohepatitis and Hepatic Fibrosis SO CURRENT DIABETES REPORTS LA English DT Review DE Obesity; Metabolic syndrome; Hepatic steatosis; Nonalcoholic fatty liver disease (NAFLD); Metabolic dysfunction associated steatotic liver disease (MASLD) ID FATTY LIVER-DISEASE; LOW-FRUCTOSE DIET; BARIATRIC SURGERY; NONALCOHOLIC STEATOHEPATITIS; PHYSICAL-ACTIVITY; OBESE-PATIENTS; STIFFNESS MEASUREMENT; PORTAL-HYPERTENSION; ALCOHOL-CONSUMPTION; MEDITERRANEAN DIET AB Purpose of ReviewThis review highlights the impact of weight loss on metabolic dysfunction associated steatotic liver disease (MASLD), formally known as nonalcoholic fatty liver disease (NAFLD), and its progressive form of metabolic dysfunction associated steatohepatitis (MASH), formally known as nonalcoholic steatohepatitis (NASH). The effects of weight loss, as achieved through lifestyle modification, pharmacotherapy, bariatric surgery or endobariatric procedures on MASLD/MASH and hepatic fibrosis are discussed.Recent FindingsAlthough foundational in the treatment of MASLD/MASH, weight loss through life-style modification is challenging for most patients to achieve and sustain long-term. In patients with MASLD/MASH, a multidisciplinary approach may facilitate success with lifestyle modification, individualized consideration of pharmacotherapies and/or surgical approaches that have potential to lend an improvement in MASLD/MASH. Effective and sustained weight loss improves hepatic steatosis, steatohepatitis and potentially hepatic fibrosis. Improvement in hepatic fibrosis can improve patient-related outcomes associated with complications of advanced hepatic fibrosis or cirrhosis in patients with MASLD/MASH.SummaryIdentifying risk factors that influence MASLD/MASH and early implementation of therapeutic weight loss strategies may improve chronic liver injury and decrease risk for adverse clinical outcomes related to progressive hepatic fibrosis attributable to MASLD/MASH. C1 [Takawy, Marina W.; Abdelmalek, Manal F.] Mayo Clin, Dept Med, Div Gastroenterol & Hepatol, Rochester, MN 55905 USA. C3 Mayo Clinic RP Abdelmalek, MF (通讯作者)，Mayo Clin, Dept Med, Div Gastroenterol & Hepatol, Rochester, MN 55905 USA. 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Tayyem, Reema Latella, Giovanni Bergheim, Ina Valenzuela, Rodrigo George, Jacob Newberry, Carolyn Zheng, Ju-Sheng George, Elena S. Spearman, C. Wendy Kontogianni, Meropi D. Ristic-Medic, Danijela Peres, Wilza Arantes Ferreira Depboylu, Gamze Yurtdas Yang, Wanshui Chen, Xu Rosqvist, Fredrik Mantzoros, Christos S. Valenti, Luca Yki-Jaervinen, Hannele Mosca, Antonella Sookoian, Silvia Misra, Anoop Yilmaz, Yusuf Kim, Won Fouad, Yasser Sebastiani, Giada Wong, Vincent Wai-Sun Aberg, Fredrik Wong, Yu Jun Zhang, Pianhong Bermudez-Silva, Francisco-Javier Ni, Yan Lupsor-Platon, Monica Chan, Wah Kheong Mendez-Sanchez, Nahum Knegt, Robert J. de Alam, Shahinul Treeprasertsuk, Sombat Wang, Li Du, Mulong Zhang, Tiejun Yu, Ming-Lung Zhang, Huijie Qi, Xingshun Liu, Xin Pinyopornpanish, Kanokwan Fan, Yu-Chen Niu, Kaijun Jimenez-Chillaron, Josep C. Zheng, Ming-Hua TI The role of dietary modification in the prevention and management of metabolic dysfunction-associated fatty liver disease: An international multidisciplinary expert consensus SO METABOLISM-CLINICAL AND EXPERIMENTAL LA English DT Article DE Metabolic dysfunction-associated fatty liver; disease; Metabolic dysfunction-associated steatotic liver; Non-alcoholic fatty liver disease; Dietary; Consensus ID LIFE-STYLE MODIFICATION; MODERATE ALCOHOL-CONSUMPTION; WEIGHT-LOSS; CLINICAL CHARACTERISTICS; NONALCOHOLIC STEATOHEPATITIS; MEDITERRANEAN DIET; DAIRY-PRODUCTS; LIPID PROFILE; ADULTS; RISK AB Metabolic dysfunction-associated fatty liver disease (MAFLD) or metabolic dysfunction-associated steatotic liver disease (MASLD), has become the leading cause of chronic liver disease worldwide. Optimal dietary intervention strategies for MAFLD are not standardized. This study aimed to achieve consensus on prevention of MAFLD through dietary modification. A multidisciplinary panel of 55 international experts, including specialists in hepatology, gastroenterology, dietetics, endocrinology and other medical specialties from six continents collaborated in a Delphi-based consensus development process. The consensus statements covered aspects ranging from epidemiology to mechanisms, management, and dietary recommendations for MAFLD. The recommended dietary strategies emphasize adherence to a balanced diet with controlled energy intake and personalized nutritional interventions, such as calorie restriction, high-protein, or low-carbohydrate diets. Specific dietary advice encouraged increasing the consumption of whole grains, plant-based proteins, fish, seafood, low-fat or fat-free dairy products, liquid plant oils, and deeply colored fruits and vegetables. Concurrently, it advised reducing the intake of red and processed meats, saturated and trans fats, ultra-processed foods, added sugars, and alcohol. 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[Kim, Won] Seoul Metropolitan Govt, Boramae Med Ctr, Dept Internal Med, Div Gastroenterol & Hepatol, Seoul, South Korea. [Fouad, Yasser] Minia Univ, Fac Med, Dept Gastroenterol Hepatol & Endem Med, Al Minya, Egypt. [Sebastiani, Giada] McGill Univ Hlth Ctr, Div Gastroenterol & Hepatol, Montreal, PQ, Canada. [Sebastiani, Giada] McGill Univ Hlth Ctr, Chron Viral Illness Serv, Montreal, PQ, Canada. [Sebastiani, Giada] McGill Univ, Div Expt Med, Montreal, PQ, Canada. [Wong, Vincent Wai-Sun] Chinese Univ Hong Kong, Dept Med & Therapeut, Hong Kong, Peoples R China. [Aberg, Fredrik] Helsinki Univ Hosp, Transplantat & Liver Surg, Helsinki, Finland. [Aberg, Fredrik] Univ Helsinki, Helsinki, Finland. [Wong, Yu Jun] Changi Gen Hosp, Dept Gastroenterol & Hepatol, Singapore, Singapore. [Wong, Yu Jun] Duke NUS Med Sch, SingHlth, Singapore, Singapore. [Zhang, Pianhong] Zhejiang Univ, Affiliated Hosp 2, Sch Med, Dept Clin Nutr, Hangzhou, Peoples R China. [Bermudez-Silva, Francisco-Javier] Inst Invest Biomed Malaga & Plataforma Nanomed IBI, Malaga, Spain. [Bermudez-Silva, Francisco-Javier] Univ Reg Hosp Malaga, Clin Unit Endocrinol & Nutr, Malaga, Spain. [Bermudez-Silva, Francisco-Javier] Spanish Biomed Res Ctr Diabet & Associated Metab D, Madrid, Spain. [Ni, Yan] Zhejiang Univ, Childrens Hosp, Natl Clin Res Ctr Child Hlth, Sch Med, Hangzhou, Peoples R China. [Lupsor-Platon, Monica] Iuliu Hatieganu Univ Med & Pharm, Prof Dr Octavian Fodor Reg Inst Gastroenterol & He, Dept Med Imaging, Cluj Napoca, Romania. [Chan, Wah Kheong; Alam, Shahinul] Univ Malaya, Fac Med, Dept Med, Gastroenterol & Hepatol Unit, Kuala Lumpur, Malaysia. [Mendez-Sanchez, Nahum] Univ Nacl Autonoma Mexico, Fac Med, Mexico City, Mexico. [Mendez-Sanchez, Nahum] Med Sur Clin & Fdn, Liver Res Unit, Mexico City, Mexico. [Knegt, Robert J. de] Erasmus MC Univ, Med Ctr, Dept Gastroenterol & Hepatol, Rotterdam, Netherlands. [Zhang, Tiejun] Bangabandhu Sheikh Mujib Med Univ, Dept Hepatol, Dhaka, Bangladesh. [Treeprasertsuk, Sombat] Chulalongkorn Univ, Fac Med, Dept Med, Div Gastroenterol, Bangkok, Thailand. [Wang, Li] Capital Med Univ, Adv Innovat Ctr Human Brain Protect, Sch Basic Med Sci, Beijing Key Lab Neural Regenerat & Repair, Beijing, Peoples R China. [Du, Mulong] Nanjing Med Univ, Ctr Global Hlth, Sch Publ Hlth, Dept Biostat, Nanjing, Peoples R China. [Zhang, Tiejun] Fudan Univ, Sch Publ Hlth, Key Lab Publ Hlth Safety, Minist Educ, Shanghai, Peoples R China. [Yu, Ming-Lung] Kaohsiung Med Univ Hosp, Dept Internal Med, Hepatobiliary Div, Kaohsiung, Taiwan. [Yu, Ming-Lung] Kaohsiung Med Univ, Coll Med, Kaohsiung, Taiwan. [Yu, Ming-Lung] Kaohsiung Med Univ, Ctr Liquid Biopsy & Cohort Res, Kaohsiung, Taiwan. [Yu, Ming-Lung] Natl Sun Yat Sen Univ, Sch Med, Kaohsiung, Taiwan. [Yu, Ming-Lung] Natl Sun Yat Sen Univ, Coll Med, Doctoral Program Clin & Expt Med, Kaohsiung, Taiwan. [Yu, Ming-Lung] Natl Sun Yat Sen Univ, Ctr Excellence Metab Associated Fatty Liver, Kaohsiung, Taiwan. [Zhang, Huijie] Southern Med Univ, Nanfang Hosp, Dept Endocrinol & Metab, Guangzhou, Peoples R China. [Qi, Xingshun] Gen Hosp Northern Theater Command, Dept Gastroenterol, Shenyang, Liaoning, Peoples R China. [Liu, Xin] Xi An Jiao Tong Univ, Global Hlth Inst, Sch Publ Hlth, Hlth Sci Ctr,Dept Epidemiol & Biostat, Xian, Peoples R China. [Pinyopornpanish, Kanokwan] Chiang Mai Univ, Fac Med, Dept Internal Med, Chiang Mai, Thailand. [Fan, Yu-Chen] Shandong Univ, Qilu Hosp, Dept Hepatol, Jinan, Peoples R China. [Niu, Kaijun] Tianjin Univ Tradit Chinese Med, Sch Publ Hlth, Tianjin, Peoples R China. [Niu, Kaijun] Tianjin Med Univ, Nutr Epidemiol Inst, Tianjin, Peoples R China. [Niu, Kaijun] Tianjin Med Univ, Sch Publ Hlth, Tianjin, Peoples R China. [Jimenez-Chillaron, Josep C.] SJD Barcelona Childrens Hosp, Inst Recerca St Joan Deu, Endocrine Div, Barcelona, Spain. [Jimenez-Chillaron, Josep C.] Univ Barcelona, Sch Med, Dept Physiol Sci, Barcelona, Spain. [Zheng, Ming-Hua] Wenzhou Med Univ, Affiliated Hosp 1, MAFLD Res Ctr, Dept Hepatol, 2 Fuxue Lane, Wenzhou 325000, Peoples R China. [Zheng, Ming-Hua] Key Lab Diag & Treatment Dev Chron Liver Dis Zheji, Wenzhou, Peoples R China. C3 Wenzhou Medical University; University of Illinois System; University of Illinois Chicago; University of Illinois Chicago Hospital; United States Department of Agriculture (USDA); Tufts University; University of Verona; University of Southampton; Qatar University; University of L'Aquila; University of Vienna; Universidad de Chile; University of Sydney; Westmead Institute for Medical Research; NSW Health; Westmead Hospital; University of Sydney; Cornell University; Weill Cornell Medicine; Weill Cornell Medical Center; Westlake Laboratory; Westlake University; Deakin University; University of Cape Town; Harokopio University Athens; University of Belgrade; Universidade Federal do Rio de Janeiro; Izmir Katip Celebi University; Anhui Medical University; Sun Yat Sen University; Uppsala University; Uppsala University; Harvard University; Harvard University Medical Affiliates; Beth Israel Deaconess Medical Center; Harvard Medical School; University of Milan; University of Helsinki; University of Helsinki; Helsinki University Central Hospital; IRCCS Bambino Gesu; Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET); Recep Tayyip Erdogan University; Seoul National University (SNU); Seoul National University (SNU); Seoul National University Hospital; Egyptian Knowledge Bank (EKB); Minia University; McGill University; McGill University; McGill University; Chinese University of Hong Kong; University of Helsinki; Helsinki University Central Hospital; University of Helsinki; Changi General Hospital; National University of Singapore; Zhejiang University; IBIMA Plataforma BIONAND, Instituto de Investigacion Biomedica de Malaga; Zhejiang University; Iuliu Hatieganu University of Medicine & Pharmacy; Universiti Malaya; Universidad Nacional Autonoma de Mexico; Erasmus University Rotterdam; Erasmus MC; Bangabandhu Sheikh Mujib Medical University (BSMMU); Chulalongkorn University; Capital Medical University; Nanjing Medical University; Fudan University; Kaohsiung Medical University; Kaohsiung Medical University Hospital; Kaohsiung Medical University; Kaohsiung Medical University; National Sun Yat Sen University; National Sun Yat Sen University; National Sun Yat Sen University; Southern Medical University - China; Xi'an Jiaotong University; Chiang Mai University; Shandong University; Tianjin University of Traditional Chinese Medicine; Tianjin Medical University; Tianjin Medical University; University of Barcelona; Wenzhou Medical University RP Zheng, MH (通讯作者)，Wenzhou Med Univ, Affiliated Hosp 1, MAFLD Res Ctr, Dept Hepatol, 2 Fuxue Lane, Wenzhou 325000, Peoples R China. EM zhengmh@wmu.edu.cn RI Bermudez-Silva, Francisco-Javier/Q-6920-2016; mosca, antonella/JTS-6893-2023; Qi, Xingshun/M-7063-2013; Jimenez-Chillaron, Josep/MBV-2513-2025; Mantzoros, Christos/Y-2902-2019; Yurtdaş, Gamze/ACA-1910-2022; George, Elena/J-3357-2019; De Knegt, Robert/X-4629-2019; Targher, Giovanni/AAB-9008-2019; Rosqvist, Fredrik/K-8975-2019; treeprasertsuk, sombat/T-6855-2019; Kontogianni, Meropi/AAN-6530-2021; Kim, Won/H-6940-2019; Wong, Vincent/K-3864-2014; Yılmaz, Yusuf Nadir/IQV-2954-2023; Chan, Wah Kheong/H-2329-2016; Pinyopornpanish, Kanokwan/AAZ-2990-2021; Fouad, Yasser/Y-7180-2018; Lupsor-Platon, Monica/B-6016-2011; George, jacob/P-1496-2014; Yu, Ming-Lung/AAZ-4306-2020; Valenti, Luca/B-3695-2009; Zhang, Tiejun/HDM-7091-2022; Niu, Kaijun/ADD-6222-2022; Zheng, Ming-Hua/H-5584-2019; Ristic-Medic, Danijela/J-6624-2013; Du, Mulong/AGV-0958-2022; Tayyem, Reema/AAA-5326-2019; Spearman, C.Wendy/R-8173-2019; Chen, Xu/NLN-8653-2025; Yang, Wanshui/S-9322-2019; Wong, Yu-Jun/AAO-8030-2020 OI Yu, Ming-Lung/0000-0001-8145-1900; Valenti, Luca/0000-0001-8909-0345; Liu, Xin/0000-0001-5105-0532; Niu, Kaijun/0000-0002-8772-2481; Zheng, Ming-Hua/0000-0003-4984-2631; Ristic-Medic, Danijela/0000-0002-7041-4220; Du, Mulong/0000-0002-2733-6490; Tayyem, Reema/0000-0003-1640-0511; Chen, Xu/0000-0002-0545-3936; Yang, Wanshui/0000-0002-7365-2689; Arantes Ferreira Peres, Wilza/0000-0003-0269-5363; Byrne, Christopher D/0000-0001-6322-7753; Wong, Yu-Jun/0000-0002-0727-1183 CR Abeysekera KWM, 2022, BMC GASTROENTEROL, V22, DOI 10.1186/s12876-022-02401-y Administration TUSFAD, FDA approves first treatment for patients with liver scarring due to fatty liver disease ADMINISTRATION USFD, Advice about eating fish for those who might become or are pregnant or breastfeeding and children ages 1-11 years Agriculture. 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Exp. PD DEC PY 2024 VL 161 AR 156028 DI 10.1016/j.metabol.2024.156028 EA SEP 2024 PG 16 WC Endocrinology & Metabolism WE Science Citation Index Expanded (SCI-EXPANDED) SC Endocrinology & Metabolism GA I9I2B UT WOS:001333309000001 PM 39270816 HC Y HP N DA 2026-02-02 ER PT J AU Simancas-Racines, D Annunziata, G Verde, L Fascì-Spurio, F Reytor-Gonzàlez, C Muscogiuri, G Frias-Toral, E Barrea, L AF Simancas-Racines, Daniel Annunziata, Giuseppe Verde, Ludovica Fasci-Spurio, Federica Reytor-Gonzalez, Claudia Muscogiuri, Giovanna Frias-Toral, Evelyn Barrea, Luigi TI Nutritional Strategies for Battling Obesity-Linked Liver Disease: the Role of Medical Nutritional Therapy in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) Management SO CURRENT OBESITY REPORTS LA English DT Review DE Obesity; Medical Nutritional Therapy (MNT); Metabolic-Associated Steatotic Liver Disease (MASLD); Mediterranean diet; Nutraceutical supplementation; Liver fibrosis ID NONALCOHOLIC FATTY LIVER; HEALTHY EATING INDEX; WEIGHT-LOSS; DIETARY FIBER; LIFE-STYLE; INSULIN-RESISTANCE; PRACTICE GUIDANCE; PATHOPHYSIOLOGY; PREVALENCE; FIBROSIS AB Purpose of ReviewThis narrative review explores the role of Medical Nutritional Therapy (MNT) in managing Metabolic-Associated Steatotic Liver Disease (MASLD), previously known as nonalcoholic fatty liver disease. It aims to examine the effectiveness of specific nutritional strategies in preventing and treating this obesity-linked liver disease.Recent FindingsEmerging evidence underscores the benefits of the Mediterranean diet, low-carbohydrate diets, and intermittent fasting in reducing liver fat, improving insulin sensitivity, and mitigating inflammation. Supplementing with vitamin E, omega-3 fatty acids, and silymarin can potentially reduce liver fibrosis and promote liver health.SummaryMNT is a key intervention for MASLD management, emphasizing dietary patterns, caloric restriction, and nutraceutical supplementation. Integrating these strategies with lifestyle modifications, including regular physical activity, offers a comprehensive approach to improving metabolic and liver outcomes in patients with MASLD. Further research is needed to refine and personalize these therapeutic interventions. C1 [Simancas-Racines, Daniel; Reytor-Gonzalez, Claudia] Univ UTE, Fac Ciencias Salud Eugenio Espejo, Ctr Invest Salud Publ & Epidemiol Clin CISPEC, Quito 170527, Ecuador. [Annunziata, Giuseppe] Univ Telemat Pegaso, Fac Sci Umane Formaz & Sport, Via Porzio,Ctr Direz,Isola F2, I-80143 Naples, Italy. [Verde, Ludovica] Univ Naples Federico II, Dept Publ Hlth, Naples, Italy. [Fasci-Spurio, Federica] Osped Angelo, Gastroenterol Unit, Venice, Italy. [Muscogiuri, Giovanna] Univ Napoli Federico II, Dipartimento Med Clin & Chirurg, Unita Endocrinol Diabetol & Androl, Via Sergio Pansini 5, I-80131 Naples, Italy. [Muscogiuri, Giovanna] Univ Napoli Federico II, Ctr Italiano Cura & Benessere Paziente Con Obes CI, Dipartimento Med Clin & Chirurg, Unita Endocrinol Diabetol & Androl, Via Sergio Pansini 5, I-80131 Naples, Italy. [Muscogiuri, Giovanna] Univ Federico II, Cattedra Unesco Educ Salute & Allo Sviluppo Sosten, I-80131 Naples, Italy. [Frias-Toral, Evelyn] Univ Espiritu Santo, Escuela Med, Samborondon 0901952, Ecuador. [Barrea, Luigi] Univ Telemat Pegaso, Dipartimento Psicol & Sci Salute, Ctr Direz Isola F2,Via Porzio, I-80143 Naples, Italy. C3 Pegaso Online University; University of Naples Federico II; ULSS 3 Serenissima; Ospedale dell'Angelo Mestre; University of Naples Federico II; University of Naples Federico II; University of Naples Federico II; Universidad de Especialidades Espiritu Santo; Pegaso Online University RP Simancas-Racines, D (通讯作者)，Univ UTE, Fac Ciencias Salud Eugenio Espejo, Ctr Invest Salud Publ & Epidemiol Clin CISPEC, Quito 170527, Ecuador.; Frias-Toral, E (通讯作者)，Univ Espiritu Santo, Escuela Med, Samborondon 0901952, Ecuador. EM dsimancas@ute.edu.ec; giuseppe.annunziata@unipegaso.it; ludovica.verde@unina.it; federica.fascispurio@aulss3.veneto.it; claudia.reytor@ute.edu.ec; giovanna.muscogiuri@unina.it; evelynft@gmail.com; luigi.barrea@unipegaso.it RI Frias-Toral, Evelyn/AAZ-7346-2020; Muscogiuri, Giovanna/K-5817-2016; Barrea, Luigi/K-6551-2016; Annunziata, Giuseppe/W-2529-2019; Verde, Ludovica/AHB-4097-2022 OI Frias-Toral, Evelyn/0000-0002-2228-0141; Barrea, Luigi/0000-0001-9054-456X; Reytor-González, Claudia/0009-0007-4234-5524; Annunziata, Giuseppe/0000-0002-1922-662X; Simancas-Racines, Daniel/0000-0002-3641-1501; Verde, Ludovica/0000-0002-4583-8283 CR Abenavoli L, 2024, MEDICINA-LITHUANIA, V60, DOI 10.3390/medicina60040563 Abuelazm MT, 2024, EUR J GASTROEN HEPAT, V36, P371, DOI 10.1097/MEG.0000000000002715 Ahmed M, 2024, J CLIN MED, V13, DOI 10.3390/jcm13133893 Albillos A, 2020, J HEPATOL, V72, P558, DOI 10.1016/j.jhep.2019.10.003 Ali H, 2024, J PERS MED, V14, DOI 10.3390/jpm14010061 Allen AM, 2024, 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Obes. Rep. PD JAN 11 PY 2025 VL 14 IS 1 AR 7 DI 10.1007/s13679-024-00597-6 PG 16 WC Endocrinology & Metabolism; Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Endocrinology & Metabolism; Nutrition & Dietetics GA R9L0K UT WOS:001394558600002 PM 39797961 OA Green Submitted, hybrid HC Y HP N DA 2026-02-02 ER PT J AU Clayton-Chubb, D Kemp, WW Majeed, A Lange, PW Fitzpatrick, JA Vaz, K Lubel, JS Hodge, AD Ryan, J Mcneil, JJ Owen, AJ Woods, RL Roberts, SK AF Clayton-Chubb, Daniel Kemp, William W. Majeed, Ammar Lange, Peter W. Fitzpatrick, Jessica A. Vaz, Karl Lubel, John S. Hodge, Alexander D. Ryan, Joanne Mcneil, John J. Owen, Alice J. Woods, Robyn L. Roberts, Stuart K. TI Steatotic Liver Disease in Older Adults: Clinical Implications and Unmet Needs SO NUTRIENTS LA English DT Review DE ageing; older adults; liver; NAFLD; MASLD; metabolic dysfunction-associated steatotic liver disease; hepatology; cardiovascular disease; lifestyle ID NONALCOHOLIC FATTY LIVER; EXERCISE PHYSICAL-ACTIVITY; ALL-CAUSE MORTALITY; WEIGHT-LOSS; MEDITERRANEAN DIET; CARDIOVASCULAR HEALTH; SOCIAL DETERMINANTS; COMPUTED-TOMOGRAPHY; METABOLIC SYNDROME; FIBROSIS STAGE AB Metabolic dysfunction-associated steatotic liver disease (MASLD) is the commonest cause of chronic liver disease worldwide. Its incidence has been increasing rapidly, alongside the growing epidemics of type 2 diabetes mellitus and overweight/obesity. Global population age has also been increasing in parallel, and predictions indicate there will be more than 2 billion persons aged over 65 by the year 2050. The interplay between MASLD and other health conditions of older persons has been a focus of recent research. In this narrative review, we aim to describe its prevalence; clinical and sociodemographic associations; and outcomes for older persons, all of which are of significant importance when considering public health messaging as well as screening and counselling individual older adults. C1 [Clayton-Chubb, Daniel; Kemp, William W.; Majeed, Ammar; Fitzpatrick, Jessica A.; Vaz, Karl; Lubel, John S.; Roberts, Stuart K.] Alfred Hlth, Dept Gastroenterol, Melbourne 3004, Australia. [Clayton-Chubb, Daniel; Kemp, William W.; Majeed, Ammar; Fitzpatrick, Jessica A.; Vaz, Karl; Lubel, John S.; Roberts, Stuart K.] Monash Univ, Sch Translat Med, Melbourne 3004, Australia. [Clayton-Chubb, Daniel; Hodge, Alexander D.] Eastern Hlth, Dept Gastroenterol, Box Hill 3128, Australia. [Lange, Peter W.] Werribee Mercy Hosp, Dept Geriatr & Gen Med, Werribee 3030, Australia. [Lange, Peter W.] Univ Melbourne, Royal Melbourne Hosp, Melbourne Med Sch, Dept Aged Care & Med, Parkville 3050, Australia. [Lubel, John S.] Northern Hlth, Dept Gastroenterol, Epping 3076, Australia. [Hodge, Alexander D.] RMIT Univ, Sch Hlth & Biomed Sci, Melbourne 3083, Australia. [Hodge, Alexander D.] Monash Univ, Eastern Clin Sch, Box Hill 3128, Australia. [Ryan, Joanne; Mcneil, John J.; Owen, Alice J.; Woods, Robyn L.] Monash Univ, Sch Publ Hlth & Prevent Med, Melbourne 3004, Australia. C3 Monash University; Eastern Health; University of Melbourne; Melbourne Health; Royal Melbourne Hospital; Royal Melbourne Institute of Technology (RMIT); Monash University; Monash University RP Clayton-Chubb, D (通讯作者)，Alfred Hlth, Dept Gastroenterol, Melbourne 3004, Australia.; Clayton-Chubb, D (通讯作者)，Monash Univ, Sch Translat Med, Melbourne 3004, Australia.; Clayton-Chubb, D (通讯作者)，Eastern Hlth, Dept Gastroenterol, Box Hill 3128, Australia. EM d.clayton-chubb@alfred.org.au; w.kemp@alfred.org.au; a.majeed@alfred.org.au; aprofpeterlange@outlook.com; jessica.fitzpatrick1@monash.edu; karl.vaz@austin.org.au; johnlubel@icloud.com; lex.hodge@monash.edu; joanne.ryan@monash.edu; john.mcneil@monash.edu; alice.owen@monash.edu; robyn.woods@monash.edu; s.roberts@alfred.org.au RI Lange, Peter/AAH-1357-2019; Woods, Robyn/K-8365-2016; Vaz, Karl/MBU-9498-2025; Kemp, William/IRZ-5250-2023 OI Lange, Peter/0000-0002-0162-1664; Clayton-Chubb, Daniel/0000-0001-7479-9669; McNeil, John/0000-0002-1049-5129; Fitzpatrick, Jessica/0000-0002-7811-8135; Woods, Robyn/0000-0003-1249-6149; Roberts, Stuart/0000-0002-9015-7997; Ryan, Joanne/0000-0002-7039-6325; Hodge, Alexander/0000-0001-6680-2303; Vaz, Karl/0000-0002-6427-6140; Kemp, William/0000-0002-0787-7273 CR Aberle JH, 2013, AGE, V35, P371, DOI 10.1007/s11357-011-9371-9 Abushamat LA, 2024, CLIN GASTROENTEROL H, V22, P1565, DOI 10.1016/j.cgh.2024.01.032 Adams LA, 2020, J GASTROEN HEPATOL, V35, P1628, DOI 10.1111/jgh.15009 Addison T, 1836, GUYS HOSP REP, V1, P485 Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x Alkhodary A. 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Green Submitted, gold DA 2026-02-02 ER PT J AU Jamil, A Chivese, T Elshaikh, U Sendall, M AF Jamil, Asma Chivese, Tawanda Elshaikh, Usra Sendall, Marguerite TI Efficacy of the Mediterranean diet in treating metabolic dysfunction-associated steatotic liver disease (MASLD) in children and adolescents: a systematic review and meta-analysis SO BMC PUBLIC HEALTH LA English DT Review DE Non-alcoholic fatty liver disease; Pediatric; Children; Mediterranean diet; MASLD ID NAFLD; HEPATOLOGY; GUIDELINE; DIAGNOSIS; NUTRITION AB BackgroundThere are limited treatment options for metabolic dysfunction-associated steatotic liver disease (MASLD), formerly known as non-alcoholic Fatty Liver Disease (MASLD) in children and adolescents.AimTo evaluate the effectiveness of the Mediterranean diet in improving liver function in children and adolescents with MASLD.MethodsIn this systematic review and meta-analysis, we searched PubMed, Scopus, Embase, CINAHL, and Cochrane CENTRAL for interventional studies investigating the effect of Mediterranean diet on MASLD in children and adolescents. The primary outcome was a change in liver function measured using these liver enzymes; Alanine Transaminase (ALT), Aspartate Transaminase (AST) and Gamma-glutamyl transferase (GGT). The secondary outcomes were lipid profile, body weight, and insulin resistance. The risk of bias was assessed using the MASTER scale. Bias-adjusted inverse variance heterogeneity models were used to synthesize overall weighted mean differences for the treatment effect (WMD) and their 95% confidence intervals. Heterogeneity and publication bias were evaluated using the I2 statistics, Tau-squared and Doi plots, respectively.ResultOut of 5915 study records identified from database searches, five studies with 308 participants, two randomized controlled trials, and three quasi-experimental studies, met the inclusion criteria. In overall synthesis, the Mediterranean diet was associated with moderate improvements in liver function as shown by reductions in the liver enzymes [ALT - WMD - 10.85 U/L, 95% CI -20.03 to -1.68, I2 = 42, T2 = 38.8, AST - WMD - 9.26 U/L, 95% CI -17.14 to -1.38, I2 = 70.7, T2 = 42.7, and GGT - WMD - 1.99 95% CI -5.09 to 1.11)], but changes in body weight, lipid profile and insulin resistance were small and insignificant.ConclusionThe Mediterranean diet may improve liver function in children with MASLD. More randomized controlled trials are needed to develop high-certainty evidence on these findings.RegistrationThis protocol was registered on the International Prospective Register of Systematic Reviews (PROSPERO) CRD42023426939. 31/05/2023. C1 [Jamil, Asma; Elshaikh, Usra; Sendall, Marguerite] Qatar Univ, Coll Hlth Sci, Dept Publ Hlth, QU Hlth, Doha, Qatar. [Chivese, Tawanda] Qatar Univ, Coll Med, Dept Populat Med, QU Hlth, Doha, Qatar. [Sendall, Marguerite] Canadian Univ Dubai, Dept Publ Hlth, Dubai, U Arab Emirates. C3 Qatar University; Qatar University; Canadian University Dubai RP Jamil, A (通讯作者)，Qatar Univ, Coll Hlth Sci, Dept Publ Hlth, QU Hlth, Doha, Qatar. EM asmajamil_7@hotmail.com RI ; Elshaikh, Usra/JAN-5149-2023; Chivese, Tawanda/AAU-3287-2021 OI Sendall, Marguerite Claire/0000-0002-1239-9173; Jamil, Asma/0000-0001-7059-8341; Elshaikh, Usra/0000-0002-2896-7649; Chivese, Tawanda/0000-0001-6621-6144 CR Akbulut UE, 2022, INT J FOOD SCI NUTR, V73, P357, DOI 10.1080/09637486.2021.1979478 Bischoff SC, 2020, CLIN NUTR, V39, P3533, DOI 10.1016/j.clnu.2020.09.001 Buzzetti E, 2021, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD013156.pub2 Della Corte C, 2017, NUTRITION, V39-40, P8, DOI 10.1016/j.nut.2017.02.008 Doi SAR, 2008, EPIDEMIOLOGY, V19, P94, DOI 10.1097/EDE.0b013e31815c24e7 e Forestali MdPA. 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Covasa, Mihai TI Dietary Influences on Gut Microbiota and Their Role in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) SO NUTRIENTS LA English DT Review DE liver disease; gut bacteria; Western diet; Mediterranean diet; ketogenic diet; intermittent fasting ID FATTY LIVER; PPAR-GAMMA; MEDITERRANEAN DIET; HEPATIC STEATOSIS; NONALCOHOLIC STEATOHEPATITIS; SYNERGISTIC INTERACTION; INTESTINAL MICROBIOTA; ENERGY-EXPENDITURE; LIPID-METABOLISM; EGG CONSUMPTION AB Metabolic dysfunction-associated steatotic liver disease (MASLD) is a major contributor to liver-related morbidity, cardiovascular disease, and metabolic complications. Lifestyle interventions, including diet and exercise, are first line in treating MASLD. Dietary approaches such as the low-glycemic-index Mediterranean diet, the ketogenic diet, intermittent fasting, and high fiber diets have demonstrated potential in addressing the metabolic dysfunction underlying this condition. The development and progression of MASLD are closely associated with taxonomic shifts in gut microbial communities, a relationship well-documented in the literature. Given the importance of diet as a primary treatment for MASLD, it is important to understand how gut microbiota and their metabolic byproducts mediate favorable outcomes induced by healthy dietary patterns. Conversely, microbiota changes conferred by unhealthy dietary patterns such as the Western diet may induce dysbiosis and influence steatotic liver disease through promoting hepatic inflammation, up-regulating lipogenesis, dysregulating bile acid metabolism, increasing insulin resistance, and causing oxidative damage in hepatocytes. Although emerging evidence has identified links between diet, microbiota, and development of MASLD, significant gaps remain in understanding specific microbial roles, metabolite pathways, host interactions, and causal relationships. 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Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most recent definition for steatotic liver disease associated with metabolic syndrome. The results of recent metabolic and observational studies suggest a potential beneficial effect of food-derived flavonoids in some chronic diseases, including MASLD. The study aims to evaluate the protective role of diet flavonoids in subjects with and without MASLD belonging to a cohort living in the South of Italy. Methods: The study cohort comprised 1297 participants assessed in the NUTRIHEP cohort (2015-2018), divided into two groups, based on presence or absence of MASLD. Results: The results indicated statistically significant flavonoid consumption, showing a protective role against MASLD, at an optimal concentration of 165 mg/day, with an OR value of 0.63, (p = 0.001, 95% C.I.: 0.47; 0.83 t). The OR remained almost unchanged when the intake increased from 165 mg per day to 185 mg per day. Conclusions: In conclusion, our study results show a protective role of flavonoids against MASLD. Consuming only 165 mg of flavonoids daily can activate this protective function, reducing the risk of MASLD. C1 [Bonfiglio, Caterina; Tatoli, Rossella; Donghia, Rossella; Guido, Davide] Natl Inst Gastroenterol IRCCS Saverio Bellis, Unit Data Sci, I-70013 Castellana Grotte, Bari, Italy. [Giannelli, Gianluigi] Natl Inst Gastroenterol IRCCS Saverio Bellis, Sci Direct, I-70013 Castellana Grotte, Bari, Italy. RP Bonfiglio, C; Tatoli, R (通讯作者)，Natl Inst Gastroenterol IRCCS Saverio Bellis, Unit Data Sci, I-70013 Castellana Grotte, Bari, Italy. EM catia.bonfiglio@irccsdebellis.it; rossella.tatoli@irccsdebellis.it; rossella.donghia@irccsdebellis.it; davide.guido@irccsdebellis.it; gianluigi.giannelli@irccsdebellis.it RI Giannelli, Gianluigi/A-8169-2012 OI Giannelli, Gianluigi/0000-0002-5140-8060; Donghia, Rossella/0000-0002-9140-673X; Tatoli, Rossella/0000-0002-7891-6057; Guido, Davide/0000-0002-3291-3686; Bonfiglio, Caterina/0000-0002-8650-348X FU Italian Ministry of Health with Ricerca Corrente 2024 [2024]; Italian Ministry of Health FX This research was funded by the Italian Ministry of Health with Ricerca Corrente 2024. 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Arrese, Marco Castro-Narro, Graciela Pessoa, Mario G. TI Updated recommendations for the management of metabolic dysfunction-associated steatotic liver disease (MASLD) by the Latin American working group SO ANNALS OF HEPATOLOGY LA English DT Article DE NAFLD; Non-alcoholic fatty liver disease; MAFLD; Non-alcoholic cirrhosis; Cirrhosis; Steatotic liver disease; Screening; Noninvasive tests; MASLD; Steatosis; Steatohepatitis ID NONALCOHOLIC FATTY LIVER; HEPATIC STEATOSIS; FIBROSIS SCORE; CARDIOVASCULAR-DISEASE; PROSPECTIVE DERIVATION; NONINVASIVE DIAGNOSIS; INSULIN SENSITIVITY; PRACTICE GUIDANCE; OBETICHOLIC ACID; CONTROLLED-TRIAL AB Metabolic dysfunction-associated steatotic liver disease (MASLD) is one of the leading causes of chronic liver disease globally. Based on the 2023 definition, MASLD is characterized by the presence of metabolic dysfunction and limited alcohol consumption (<140 grams/week for women, <210 grams/week for men). Given the significant burden of MASLD in Latin America, this guidance was developed by the Latin American Association for the Study of the Liver (ALEH) Working Group to address key aspects of its clinical assessment and therapeutic strategies. In Latin America, ultrasonography is recommended as the initial screening tool for hepatic steatosis due to its accessibility, while Fibrosis-4 (FIB-4) is preferred for fibrosis risk stratification, with further evaluation using more specific techniques (i.e., vibration-controlled transient elastography or Enhanced Liver Fibrosis [ELF] test). A Mediterranean diet is advised for all MASLD patients, with a target of 7-10% weight loss for those with excess weight. Complete alcohol abstinence is recommended for patients with significant fibrosis, and smoking cessation is encouraged regardless of fibrosis stage. Pharmacological options should be tailored based on the presence of steatohepatitis, liver fibrosis, excess weight, and diabetes, including resmetirom, incretin-based therapies, pioglitazone, and sodium-glucose cotransporter-2 inhibitors. Bariatric surgery may be considered for MASLD patients with obesity unresponsive to lifestyle and medical interventions. Hepatocellular carcinoma screening is advised for all cirrhotic patients, with consideration given to those with advanced fibrosis based on individual risk. Finally, routine cardiovascular risk assessment and proper diabetes prevention and management remain crucial for all patients with MASLD. (c) 2025 Fundacion Clinica Medica Sur, A.C. Published by Elsevier Espana, S.L.U. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/) C1 [Diaz, Luis Antonio] Univ Calif San Diego, MASLD Res Ctr, Div Gastroenterol & Hepatol, San Diego, CA 92093 USA. [Diaz, Luis Antonio; Arab, Juan Pablo; Idalsoaga, Francisco; Arrese, Marco] Pontificia Univ Catolica Chile, Escuela Med, Dept Gastroenterol, Santiago, Chile. [Arab, Juan Pablo] Virginia Commonwealth Univ, Sch Med, Dept Internal Med, Div Gastroenterol Hepatol & Nutr, Richmond, VA USA. [Idalsoaga, Francisco] Western Univ, Schulich Sch Med, Dept Med, Div Gastroenterol, London, ON, Canada. [Idalsoaga, Francisco] London Hlth Sci Ctr, London, ON, Canada. [Perelli, Javiera] Clin Univ Andes, Unidad Diabetesy Nutr Clin, Santiago, Chile. [Vega, Javier; Samith, Barbara] Pontificia Univ Catolica Chile, Escuela Med, Dept Nutr Diabet & Metab, Santiago, Chile. [Dirchwolf, Melisa] Hosp Privado Rosario, Liver Unit, Rosario, Argentina. [Carreno, Javiera] Asociac LatinoamericanaPara Estudio Higado ALEH, Santiago, Chile. [Valerio, Cynthia; Moreira, Rodrigo Oliveira] Inst Estadual Diabet & Endocrinol Luiz Caprigl, Rio De Janeiro, RJ, Brazil. [Moreira, Rodrigo Oliveira] Ctr Univ Valenca, Fac Med Valenca, Valenca, RJ, Brazil. [Moreira, Rodrigo Oliveira] Ctr Univ Presidente Antonio Carlos, Fac Med, Juiz De Fora, MG, Brazil. [Acevedo, Monica] Pontificia Univ Catolica Chile, Fac Med, Div Enfermedades Cardiovasc, Santiago, Chile. [Brahm, Javier] Clin Univ los Andes, Unidad Gastroenterol, Santiago, Chile. [Hernandez, Nelia] Univ Republica, Hosp Clin, Montevideo, Uruguay. [Gadano, Adrian] Hosp Italiano Buenos Aires, Liver Unit, Buenos Aires, Argentina. [Gadano, Adrian] Hosp Italiano Buenos Aires, Dept Res, Buenos Aires, Argentina. [Oliveira, Claudia P.; Pessoa, Mario G.] Univ Sao Paulo, Hosp Clin LIM07 HCFMUSP, Fac Med, Gastroenterol Dept, Sao Paulo, Brazil. [Castro-Narro, Graciela] Inst Nacl Ciencias Medicasy Nutr Salvador Zubiran, Dept Gastroenterol, Mexico City, Mexico. [Castro-Narro, Graciela] Med Sur Clin & Fdn, Mexico City, Mexico. C3 University of California System; University of California San Diego; Pontificia Universidad Catolica de Chile; Virginia Commonwealth University; Western University (University of Western Ontario); London Health Sciences Centre; Universidad de los Andes - Chile; Pontificia Universidad Catolica de Chile; Pontificia Universidad Catolica de Chile; Clinica Los Andes; Universidad de la Republica, Uruguay; Hospital Italiano de Buenos Aires; University of Buenos Aires; University of Buenos Aires Hospital; Hospital Italiano de Buenos Aires; University of Buenos Aires; University of Buenos Aires Hospital; Universidade de Sao Paulo RP Diaz, LA (通讯作者)，Univ Calif San Diego, MASLD Res Ctr, Div Gastroenterol & Hepatol, San Diego, CA 92093 USA.; Diaz, LA (通讯作者)，Pontificia Univ Catolica Chile, Escuela Med, Dept Gastroenterol, Santiago, Chile. EM ldiazpiga@health.ucsd.edu RI Idalsoaga, Francisco/MTB-1697-2025; Castro-Narro, Graciela/JYO-8044-2024; ARRESE, MARCO/ABB-9061-2021; hernandez, nelia/GLQ-6250-2022; Valerio, Cynthia/ABI-5704-2020; Arab, Juan Pablo/J-5674-2019 OI Samith, Barbara/0009-0004-8782-7170; Valerio, Cynthia/0000-0003-2292-1735; FU Fondo Nacional de Desarrollo Cientifico y Tecnologico (FONDECYT) [1241450]; Novo Nordisk; Summit Task Force on Steatotic Liver Disease through the Latin American Association for the Study of the Liver (ALEH) FX M.A. receives support from the Chilean government through the Fondo Nacional de Desarrollo Cientifico y Tecnologico (FONDECYT 1241450) . We acknowledge Novo Nordisk for supporting the Summit Task Force on Steatotic Liver Disease through the Latin American Association for the Study of the Liver (ALEH) . 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Hepatol. PD JUL-DEC PY 2025 VL 30 IS 2 AR 101903 DI 10.1016/j.aohep.2025.101903 EA JUN 2025 PG 20 WC Gastroenterology & Hepatology WE Science Citation Index Expanded (SCI-EXPANDED) SC Gastroenterology & Hepatology GA 4IZ2N UT WOS:001519149200002 PM 40089151 OA gold HC Y HP Y DA 2026-02-02 ER PT J AU Sualeheen, A Tan, SY Georgousopoulou, E Daly, RM Tierney, AC Roberts, SK George, ES AF Sualeheen, Ayesha Tan, Sze-Yen Georgousopoulou, Ekavi Daly, Robin M. Tierney, Audrey C. Roberts, Stuart K. George, Elena S. TI Mediterranean diet for the management of metabolic dysfunction-associated steatotic liver disease in non-Mediterranean, Western countries: What's known and what's needed? SO NUTRITION BULLETIN LA English DT Review DE digital health; fatty liver; lifestyle; MASLD; Mediterranean diet; NAFLD ID LOW-FAT DIETS; INSULIN SENSITIVITY; WHOLE-GRAIN; CARDIOVASCULAR-DISEASE; HEPATIC STEATOSIS; PHYSICAL-ACTIVITY; LIPID-METABOLISM; METAANALYSIS; INDIVIDUALS; CONSUMPTION AB Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common liver disease worldwide, affecting 30% of the population in Western countries. MASLD is considered the hepatic manifestation of the metabolic syndrome, pathophysiologically underpinned by insulin resistance and frequently co-exists with hypertension, central obesity and dyslipidaemia. Currently, safe and effective pharmacotherapies for MASLD are limited, making weight loss with lifestyle changes the mainstay therapy. A Mediterranean diet (MedDiet) has emerged as an effective dietary pattern for preventing and managing MASLD, but most studies have been conducted in Mediterranean countries, necessitating further investigation into its benefits in Western populations. Additionally, the effect of holistic multimodal lifestyle interventions, including physical activity combined with the MedDiet, is not well established. Finally, MASLD's widespread prevalence and rapid growth require improved accessibility to interventions. Digital health delivery platforms, designed for remote access, could be a promising approach to providing timely support to individuals with MASLD. This narrative review summarises the current evidence related to the effects of the MedDiet in Western, multicultural populations with MASLD. This includes a detailed description of the composition, prescription and adherence to dietary interventions in terms of how they have been designed and applied. The evidence related to the role of physical activity or exercise interventions prescribed in combination with the MedDiet for MASLD will also be reviewed. Finally, recommendations for the design and delivery of dietary and physical activity or exercise interventions to inform the design of future randomised controlled trials to facilitate the optimal management of MASLD are outlined. C1 [Sualeheen, Ayesha; Tan, Sze-Yen; Daly, Robin M.; George, Elena S.] Deakin Univ, Inst Phys Act & Nutr, Sch Exercise & Nutr Sci, Geelong, Vic, Australia. [Georgousopoulou, Ekavi] Univ Canberra, Fac Hlth, Discipline Nutr & Dietet, Canberra, ACT, Australia. [Tierney, Audrey C.] Univ Limerick, Hlth Res Inst, Ctr Implementat Res, Sch Allied Hlth, Limerick, Ireland. [Roberts, Stuart K.] Alfred Hlth, Dept Gastroenterol, Prahran, Vic, Australia. [Roberts, Stuart K.] Monash Univ, Cent Clin Sch, Clayton, Vic, Australia. 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PD DEC PY 2024 VL 49 IS 4 BP 444 EP 462 DI 10.1111/nbu.12707 EA SEP 2024 PG 19 WC Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Nutrition & Dietetics GA M2G8F UT WOS:001309388400001 PM 39258424 OA hybrid DA 2026-02-02 ER PT J AU Mellemkjær, A Kjær, MB Haldrup, D Gronbæk, H Thomsen, KL AF Mellemkjaer, Anders Kjaer, Mikkel Breinholt Haldrup, David Gronbaek, Henning Thomsen, Karen Louise TI Management of cardiovascular risk in patients with metabolic dysfunction-associated steatotic liver disease SO EUROPEAN JOURNAL OF INTERNAL MEDICINE LA English DT Review ID NONALCOHOLIC FATTY LIVER; 12 MEDICAL SOCIETIES; 2021 ESC GUIDELINES; HEART-DISEASE; TASK-FORCE; EUROPEAN ASSOCIATION; MEDITERRANEAN DIET; INSULIN-RESISTANCE; CLINICAL-PRACTICE; CONTROLLED-TRIAL AB The novel term Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) is proposed to replace non-alcoholic fatty liver disease (NAFLD) to highlight the close association with the metabolic syndrome. MASLD encompasses patients with liver steatosis and at least one of five cardiometabolic risk factors which implies that these patients are at increased risk of cardiovascular disease (CVD). Indeed, the prevalence of CVD in MASLD patients is increased and CVD is recognized as the most common cause of death in MASLD patients. We here present an update on the pathophysiology of CVD in MASLD, discuss the risk factors, and suggest screening for CVD in patients with MASLD. Currently, there is no FDA-approved pharmacological treatment for MASLD, and no specific treatment recommended for CVD in patients with MASLD. Thus, the treatment strategy is based on weight loss and a reduction and treatment of CVD risk factors. We recommend screening of MASLD patients for CVD using the SCORE2 system with guidance to specific treatment algorithms. In all patients with CVD risk factors, lifestyle intervention to induce weight loss through diet and exercise is recommended. Especially a Mediterranean diet may improve hyperlipidemia and if further treatment is needed, statins should be used as first-line treatment. Further, anti-hypertensive drugs should be used to treat hypertension. With the epidemic of obesity and type 2 diabetes mellitus (T2DM) the risk of MASLD and CVD is expected to increase, and preventive measures, screening, and effective treatments are highly needed to reduce morbidity and mortality in MASLD patients. C1 [Mellemkjaer, Anders; Kjaer, Mikkel Breinholt; Haldrup, David; Gronbaek, Henning; Thomsen, Karen Louise] Aarhus Univ Hosp, Dept Hepatol & Gastroenterol, Aarhus, Denmark. [Mellemkjaer, Anders; Kjaer, Mikkel Breinholt; Haldrup, David; Gronbaek, Henning; Thomsen, Karen Louise] Aarhus Univ, Dept Clin Med, Aarhus, Denmark. C3 Aarhus University; Aarhus University RP Gronbæk, H (通讯作者)，Aarhus Univ Hosp, Dept Hepatol & Gastroenterol, Aarhus, Denmark.; Gronbæk, H (通讯作者)，Aarhus Univ, Dept Clin Med, Aarhus, Denmark. EM henngroe@rm.dk RI ; Grønbæk, Henning/AAJ-3202-2020 OI Thoen, Karen Louise/0000-0002-8118-4643; Grønbæk, Henning/0000-0001-8998-7910; Kjær, Mikkel Breinholt/0000-0002-6385-5108; Mellemkjær, Anders/0000-0002-1909-9990 FX Anders Mellemkja r: No conflicts of interest. David Haldrup: No conflicts of interest. Mikkel Breinholt Kja r: No conflicts of interest. Karen Louise Thomsen: Research grants: NOVO Nordisk Foundation. Advisory board: NOVO Nordisk. Henning GrOnbak: O nbak: Research grants: Abbvie, Intercept, ARLA Food for Health, ADS AIPHIA Development Services AG; Consulting Fees: Ipsen, NOVO Nordisk, Pfizer; Lecturer: AstraZeneca, NOVO Nordisk, EISAI; Data Monitoring Committee: CAMURUS AB. 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PD APR PY 2024 VL 122 BP 28 EP 34 DI 10.1016/j.ejim.2023.11.012 EA APR 2024 PG 7 WC Medicine, General & Internal WE Science Citation Index Expanded (SCI-EXPANDED) SC General & Internal Medicine GA D9R2L UT WOS:001299473300001 PM 38008609 OA Green Submitted, hybrid HC Y HP N DA 2026-02-02 ER PT J AU Huang, X Gan, D Fan, YH Fu, QH He, C Liu, WJ Li, F Ma, L Wang, MX Zhang, W AF Huang, Xia Gan, Da Fan, Yahui Fu, Qihui He, Cong Liu, Wenjian Li, Feng Ma, Le Wang, Mingxu Zhang, Wei TI The Associations between Healthy Eating Patterns and Risk of Metabolic Dysfunction-Associated Steatotic Liver Disease: A Case-Control Study SO NUTRIENTS LA English DT Article DE metabolic dysfunction-associated steatotic liver disease; Alternate Healthy Eating Index; Dietary Approaches to Stop Hypertension; Alternative Mediterranean Diet; vegetables; whole grain ID FATTY LIVER; DIETARY PATTERNS; MEDITERRANEAN DIET; PHYSICAL-ACTIVITY; ADHERENCE; WOMEN; NAFLD; ATHEROSCLEROSIS; QUESTIONNAIRE; INFLAMMATION AB Background: Although several epidemiological studies have identified an inverse association between healthy dietary patterns and metabolic dysfunction-associated steatotic liver disease (MASLD)/non-alcoholic fatty liver disease (NAFLD), little is known about the contribution of the food component to MASLD risk and the association between dietary patterns and severity of MASLD. This study aimed to investigate the association between healthy eating patterns and MASLD risk and severity of MASLD. Methods: A case-control study including 228 patients diagnosed with MASLD and 228 controls was conducted. The modified Alternate Healthy Eating Index (AHEI), Dietary Approaches to Stop Hypertension (DASH) score, and Alternative Mediterranean Diet (AMED) score were evaluated based on information collected via a validated food-frequency questionnaire. MASLD was confirmed if participants presented with ultrasound-diagnosed fatty liver diseases along with at least one of five cardiometabolic risk factors and no other discernible cause. The logistic regression models were applied to estimate the odds ratio (OR) and 95% confidence interval (95% CI) of MASLD for dietary scores. Results: Compared with participants in the lowest tertile, those in the highest tertile of AHEI had a 60% reduced risk of MASLD (OR: 0.40; 95% CI: 0.25-0.66). Similar associations were also observed for DASH and AMED, with ORs comparing extreme tertiles of 0.38 (95% CI: 0.22-0.66) and 0.46 (95% CI: 0.28-0.73), respectively. Further Stratified analysis revealed that the inverse associations between AHEI and DASH with MASLD risks were stronger among women than men, and the inverse associations between AMED and MASLD risks were more pronounced among participants with normal weight (OR: 0.22; 95% CI: 0.09-0.49). For components within the dietary score, every one-point increase in vegetable score and whole grain score within the AHEI was associated with an 11% (95% CI: 5-16%) and a 6% (95% CI: 0-12%) lower MASLD risk, respectively. Similar inverse associations with those scores were observed for the DASH and AMED. Conclusion: Greater adherence to healthy eating patterns was associated with reduced risk of MASLD, with vegetables and whole grains predominately contributing to these associations. These findings suggested that healthy eating patterns should be recommended for the prevention of MASLD. C1 [Huang, Xia; Zhang, Wei] Xi An Jiao Tong Univ, Hlth Sci Ctr, Affiliated Hosp 1, Xian 710061, Peoples R China. [Huang, Xia; Fan, Yahui; Ma, Le; Wang, Mingxu] Xi An Jiao Tong Univ, Hlth Sci Ctr, Sch Publ Hlth, Xian 710061, Peoples R China. [Huang, Xia; Gan, Da; Fu, Qihui; Liu, Wenjian; Li, Feng] Nanchang Univ, Affiliated Hosp 1, Jiangxi Med Acad Nutr & Hlth Management, Jiangxi Med Coll, Nanchang 330006, Peoples R China. [He, Cong] Nanchang Univ, Affiliated Hosp 1, Jiangxi Med Coll, Dept Gastroenterol, Nanchang 330006, Peoples R China. [Ma, Le; Wang, Mingxu] Key Lab Dis Prevent & Control & Hlth Promot Shaanx, Xian 710061, Peoples R China. [Ma, Le] Xi An Jiao Tong Univ, Minist Educ China, Key Lab Environm & Genes Related Dis, Xian 710061, Peoples R China. C3 Xi'an Jiaotong University; Xi'an Jiaotong University; Nanchang University; Nanchang University; Xi'an Jiaotong University RP Zhang, W (通讯作者)，Xi An Jiao Tong Univ, Hlth Sci Ctr, Affiliated Hosp 1, Xian 710061, Peoples R China.; Ma, L (通讯作者)，Xi An Jiao Tong Univ, Hlth Sci Ctr, Sch Publ Hlth, Xian 710061, Peoples R China.; Ma, L (通讯作者)，Key Lab Dis Prevent & Control & Hlth Promot Shaanx, Xian 710061, Peoples R China.; Ma, L (通讯作者)，Xi An Jiao Tong Univ, Minist Educ China, Key Lab Environm & Genes Related Dis, Xian 710061, Peoples R China. EM ndyfy00382@ncu.edu.cn; ganda@ncu.edu.cn; fyh14042166@stu.xjtu.edu.cn; fuqihui@email.ncu.edu.cn; ndydy04758@ncu.edu.cn; ndyfy10076@ncu.edu.cn; montanezd@email.phoenix.edu; male@mail.xjtu.edu.cn; wangmx601@mail.xjtu.edu.cn; zhangwei2721@xjtufh.edu.cn RI ; wang, mingxu/LIH-0038-2024; he, cong/KJM-7213-2024 OI ma, le/0000-0001-7592-9779; FU Jiangxi Medicine Academy of Nutrition and Health Management [2022-PYXM-02]; Science and technologyresearch project of the Education Department of Jiangxi Province [GJJ2200101] FX This study was supported by grants from the Cultivation Project of Jiangxi MedicineAcademy of Nutrition and Health Management (2022-PYXM-02) and the science and technologyresearch project of the Education Department of Jiangxi Province (GJJ2200101). 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Ben Saad, Amel Rahman, Raza-Ur Habboub, Tim Pratt, Daniel S. Mullen, Alan C. TI Single-cell transcriptomics stratifies organoid models of metabolic dysfunction-associated steatotic liver disease SO EMBO JOURNAL LA English DT Article DE fibrosis; liver organoids; MASLD; NAFLD; single-cell RNA-sequencing ID HEPATIC STELLATE CELLS; PALMITIC ACID; NONALCOHOLIC STEATOHEPATITIS; REGULATES FIBROSIS; MEDITERRANEAN DIET; RECEPTOR; EXPRESSION; DIFFERENTIATION; LIPOTOXICITY; PATHOGENESIS AB Metabolic dysfunction-associated steatotic liver disease (MASLD) is a growing cause of morbidity with limited treatment options. Thus, accurate in vitro systems to test new therapies are indispensable. While recently, human liver organoid models have emerged to assess steatotic liver disease, a systematic evaluation of their translational potential is still missing. Here, we evaluated human liver organoid models of MASLD, comparatively testing disease induction in three conditions: oleic acid, palmitic acid, and TGF-beta 1. Through single-cell analyses, we find that all three models induce inflammatory signatures, but only TGF-beta 1 promotes collagen production, fibrosis, and hepatic stellate cell expansion. In striking contrast, oleic acid ameliorates fibrotic signatures and reduces the hepatic stellate cell population. Linking data from each model to gene expression signatures associated with MASLD disease progression further demonstrates that palmitic acid and TGF-beta 1 more robustly model inflammation and fibrosis. Our findings highlight the importance of stratifying MASLD organoid models by signatures of clinical disease progression, provide a single-cell reference to benchmark future organoid injury models, and allow us to study evolving steatohepatitis, fibrosis, and HSC susceptibility to injury in a dynamic, multi-lineage human in vitro system. imageMetabolic dysfunction-associated steatotic liver disease (MASLD, formerly NAFLD) is a major cause of chronic hepatic injury and failure, however the details of its induction remain unclear. This benchmark resource reports in vitro dissection of fatty liver disease in human organoids uncovering distinct disease phenotypes triggered by specific lipids.Human pluripotent stem cell-derived liver organoids serve as models for injury related to MASLD.Palmitic acid induces inflammatory signatures while TGF-beta 1 signaling induces inflammatory and fibrotic signatures.Oleic acid reduces hepatic stellate cell numbers and suppresses collagen production.Gene expression predicting MASLD severity increases from palmitic acid to TGF-beta 1 treatment. Comprehensive dissection of fatty liver disease in human organoids uncovers unexpected phenotype heterogeneity triggered by specific fatty acids.image C1 [Hess, Anja; Gentile, Stefan D.; Ben Saad, Amel; Rahman, Raza-Ur; Habboub, Tim; Pratt, Daniel S.; Mullen, Alan C.] Harvard Med Sch, Massachusetts Gen Hosp, Div Gastroenterol, Boston, MA 02115 USA. [Gentile, Stefan D.; Mullen, Alan C.] Broad Inst MIT & Harvard, Klarman Cell Observ, Cambridge, MA 02142 USA. [Pratt, Daniel S.] Massachusetts Gen Hosp, Autoimmune & Cholestat Liver Ctr, Boston, MA USA. [Mullen, Alan C.] Massachusetts Gen Hosp, Ctr Study Inflammatory Bowel Dis, Boston, MA 02114 USA. [Mullen, Alan C.] Harvard Stem Cell Inst, Cambridge, MA 02138 USA. [Hess, Anja] Max Planck Inst Mol Genet, Dept Genome Regulat, Berlin, Germany. [Mullen, Alan C.] Univ Massachusetts, Chan Med Sch, Worcester, MA 01605 USA. C3 Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Max Planck Society; University of Massachusetts System; UMass Chan Medical School; University of Massachusetts Worcester RP Mullen, AC (通讯作者)，Harvard Med Sch, Massachusetts Gen Hosp, Div Gastroenterol, Boston, MA 02115 USA.; Mullen, AC (通讯作者)，Broad Inst MIT & Harvard, Klarman Cell Observ, Cambridge, MA 02142 USA.; Mullen, AC (通讯作者)，Massachusetts Gen Hosp, Ctr Study Inflammatory Bowel Dis, Boston, MA 02114 USA.; Mullen, AC (通讯作者)，Harvard Stem Cell Inst, Cambridge, MA 02138 USA.; Mullen, AC (通讯作者)，Univ Massachusetts, Chan Med Sch, Worcester, MA 01605 USA. EM alan.mullen@umassmed.edu RI ; Hess, Anja/HTS-7873-2023 OI Rahman, Raza-Ur/0000-0002-7019-5486; Ben Saad, Amel/0000-0003-2105-1491; Hess, Anja/0000-0001-6634-9502; Mullen, Alan/0000-0002-4096-3106 FU AH was supported by the Studienstiftung des deutschen Volkes. ACM and DSP were supported by PSC Partners Seeking a Cure Canada. ACM was also supported through internal funding at MGH, and DSP also received support from the Registry of PSC (primary sclerosi; Studienstiftung des deutschen Volkes; PSC Partners Seeking a Cure Canada; Registry of PSC FX AH was supported by the Studienstiftung des deutschen Volkes. ACM and DSP were supported by PSC Partners Seeking a Cure Canada. ACM was also supported through internal funding at MGH, and DSP also received support from the Registry of PSC (primary sclerosing cholangitis) at Massachusetts General Hospital. The authors thank Gary Bader, Tallulah Andrews, and Ramnik Xavier for helpful discussions, Cristin McCabe and Jacques Deguine for assistance with data management, and Adam Slamin, Dan Dubinsky, and the Broad Genomics Platform for help with generation of single-cell sequencing data. The authors also thank the Massachusetts General Hospital NextGen Sequencing Core for additional assistance with generation of single-cell sequencing data, the Harvard Stem Cell Institute iPS Core facility, under the direction of Laurence Daheron, for the derivation of the iPSC4 line, and Annika Gabriel for designing color palettes used in the manuscript. Synopsis graphics were created with . 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PD DEC 11 PY 2023 VL 42 IS 24 DI 10.15252/embj.2023113898 EA NOV 2023 PG 25 WC Biochemistry & Molecular Biology; Cell Biology WE Science Citation Index Expanded (SCI-EXPANDED) SC Biochemistry & Molecular Biology; Cell Biology GA AX9C3 UT WOS:001101656200001 PM 37962490 OA Green Submitted, hybrid DA 2026-02-02 ER PT J AU Reytor-González, C Simancas-Racines, D Campuzano-Donoso, M Jimenez, JC Román-Galeano, NM Sarno, G Frias-Toral, E AF Reytor-Gonzalez, Claudia Simancas-Racines, Daniel Campuzano-Donoso, Martin Castano Jimenez, Janeth Roman-Galeano, Nathaly Mercedes Sarno, Gerardo Frias-Toral, Evelyn TI Harnessing nutrition to combat MASLD: a comprehensive guide to food-based therapeutic strategies SO FOOD AND AGRICULTURAL IMMUNOLOGY LA English DT Review DE MASLD; Mediterranean diet; ketogenic diet; gut microbiota; nutraceuticals; healthcare ID FATTY LIVER-DISEASE; INSULIN-RESISTANCE; OXIDATIVE STRESS; VITAMIN-D; DYSFUNCTION; SUPPLEMENTATION; GLUCOSE; LIPIDS; ACIDS; DIET AB Metabolic dysfunction-associated steatotic liver disease is a growing global health issue linked to obesity, insulin resistance, and metabolic syndrome. Diet plays a key role in its progression and management. This narrative review highlights evidence-based nutritional strategies, including the Mediterranean diet, low-carbohydrate and ketogenic diets, and high-fiber intake, which improve insulin sensitivity, reduce hepatic fat, and lower inflammation. Nutritional deficiencies, such as low vitamin D, choline, and omega-3 levels, exacerbate metabolic dysfunction-associated steatotic liver disease, emphasizing the need for targeted supplementation. Emerging approaches, including gut microbiota modulation, precision nutrition, and nutraceuticals like resveratrol and curcumin, offer promising therapeutic potential. A multidisciplinary approach integrating dietary and lifestyle modifications is essential for effective metabolic dysfunction-associated steatotic liver disease management. C1 [Reytor-Gonzalez, Claudia; Simancas-Racines, Daniel; Campuzano-Donoso, Martin; Roman-Galeano, Nathaly Mercedes] Univ UTE, Fac Ciencias Salud Eugenio Espejo, Ctr Invest Salud Publ & Epidemiol Clin CISPEC, Quito 170527, Ecuador. [Castano Jimenez, Janeth] Indiana Univ Sch Med, Dept Emergency Med, Indianapolis, IN USA. [Sarno, Gerardo] San Giovanni Dio & Ruggi DAragona Univ Hosp, Salerno, Italy. [Frias-Toral, Evelyn] Univ Espiritu Santo, Escuela Med, Samborondon, Ecuador. [Frias-Toral, Evelyn] Texas State Univ, Div Res, San Marcos, TX USA. C3 Indiana University System; Indiana University Bloomington; Universidad de Especialidades Espiritu Santo; Texas State University System; Texas State University San Marcos RP Simancas-Racines, D (通讯作者)，Univ UTE, Fac Ciencias Salud Eugenio Espejo, Ctr Invest Salud Publ & Epidemiol Clin CISPEC, Quito 170527, Ecuador. EM dsimancas@ute.edu.ec RI ; Frias-Toral, Evelyn/AAZ-7346-2020; Sarno, Gerardo/GRJ-3733-2022; Campuzano Donoso, Martín/LTD-0339-2024; Castano Jimenez, Janeth C/LFV-0273-2024 OI Simancas-Racines, Daniel/0000-0002-3641-1501; Frias-Toral, Evelyn/0000-0002-2228-0141; Sarno, Gerardo/0000-0002-1161-0846; Román-Galeano, Náthaly Mercedes/0000-0002-6417-5550; Campuzano Donoso, Martín/0000-0001-5317-8548; Reytor-González, Claudia/0009-0007-4234-5524; Castano Jimenez, Janeth C/0009-0005-3495-1802 FU Universidad UTE; Universidad UTE FX The authors are grateful to Universidad UTE for their support. 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Immunol. PD DEC 31 PY 2025 VL 36 IS 1 AR 2496499 DI 10.1080/09540105.2025.2496499 PG 26 WC Chemistry, Applied; Food Science & Technology; Immunology; Toxicology WE Science Citation Index Expanded (SCI-EXPANDED) SC Chemistry; Food Science & Technology; Immunology; Toxicology GA 2IO9J UT WOS:001483516100001 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Commins, I Clayton-Chubb, D Fitzpatrick, JA George, ES Schneider, HG Phyo, AZZ Majeed, A Janko, N Vaughan, N Woods, RL Owen, AJ McNeil, JJ Kemp, WW Roberts, SK AF Commins, Isabella Clayton-Chubb, Daniel Fitzpatrick, Jessica A. George, Elena S. Schneider, Hans G. Phyo, Aung Zaw Zaw Majeed, Ammar Janko, Natasha Vaughan, Nicole Woods, Robyn L. Owen, Alice J. McNeil, John J. Kemp, William W. Roberts, Stuart K. TI Associations Between MASLD, Ultra-Processed Food and a Mediterranean Dietary Pattern in Older Adults SO NUTRIENTS LA English DT Article DE epidemiology; fatty liver; dietary patterns; healthy ageing; nutrition ID FATTY LIVER-DISEASE; REDUCING EVENTS; RISK; EXPENDITURES; ACCUMULATION; INSECURITY; VALIDATION; DISABILITY; ASPIRIN; FRAILTY AB Background/Objectives: Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) is the most common liver disease worldwide, affecting 38% of the adult population globally. Methods: We examined the impact of the Mediterranean Diet and Ultra Processed Food (UPF) intake on the risk of prevalent MASLD in older adults. Results: Our major findings include that increased adherence to a Mediterranean Dietary pattern was associated with a decreased risk of MASLD. Additionally, we found that high UPF intake was associated with an increased risk of MASLD. Furthermore, our study found that even with a high UPF intake, the risk of MASLD decreased if the individual also had a higher Mediterranean Diet intake compared to a lower Mediterranean Diet intake. Conclusions: These results are of particular importance in older people, given the known links between MASLD, metabolic comorbidities and frailty. Public health messaging should focus on promoting Mediterranean dietary habits, and ways to help older people achieve this given the social and economic barriers they may face. C1 [Commins, Isabella; Clayton-Chubb, Daniel; Fitzpatrick, Jessica A.; Majeed, Ammar; Janko, Natasha; Vaughan, Nicole; Kemp, William W.; Roberts, Stuart K.] Alfred Hlth, Dept Gastroenterol, Melbourne, Vic 3004, Australia. [Commins, Isabella; Clayton-Chubb, Daniel; Fitzpatrick, Jessica A.; Majeed, Ammar; Janko, Natasha; Kemp, William W.; Roberts, Stuart K.] Monash Univ, Sch Translat Med, Melbourne, Vic 3004, Australia. [Clayton-Chubb, Daniel] Eastern Hlth, Dept Gastroenterol, Box Hill, Vic 3128, Australia. [Clayton-Chubb, Daniel] St Vincents Hosp Melbourne, Dept Gastroenterol, Fitzroy, Vic 3065, Australia. [George, Elena S.] Deakin Univ, Inst Phys Act & Nutr IPAN, Sch Exercise & Nutr Sci, Geelong, Vic 3220, Australia. [Schneider, Hans G.; Phyo, Aung Zaw Zaw; Woods, Robyn L.; Owen, Alice J.] Monash Univ, Sch Publ Hlth & Prevent Med, Melbourne, Vic 3004, Australia. [Schneider, Hans G.] Alfred Hlth, Dept Pathol, Melbourne, Vic 3004, Australia. [Vaughan, Nicole] Alfred Hlth, Dept Nutr & Dietet, Melbourne, Vic 3004, Australia. C3 Alfred Health; Monash University; Eastern Health; St Vincent's Health; St Vincent's Hospital Melbourne; Deakin University; Monash University; Alfred Health; Alfred Health RP Roberts, SK (通讯作者)，Alfred Hlth, Dept Gastroenterol, Melbourne, Vic 3004, Australia.; Roberts, SK (通讯作者)，Monash Univ, Sch Translat Med, Melbourne, Vic 3004, Australia. EM i.commins@alfred.org.au; d.clayton-chubb@alfred.org.au; jessicafitzaptrick1@monash.edu; elena.george@deakin.edu.au; h.schneider@alfred.org.au; aungzawzaw.phyo@monash.edu; a.majeed@alfred.org.au; n.janko@alfred.org.au; n.vaughan@alfred.org.au; robyn.woods@monash.edu; alice.owen@monash.edu; john.mcneil@monash.edu; w.kemp@alfred.org.au; s.roberts@alfred.org.au RI Kemp, William/IRZ-5250-2023; George, Elena/J-3357-2019 OI Kemp, William/0000-0002-0787-7273; George, Elena/0000-0002-1385-2371; McNeil, John/0000-0002-1049-5129; Woods, Robyn/0000-0003-1249-6149; Roberts, Stuart/0000-0002-9015-7997; Clayton-Chubb, Daniel/0000-0001-7479-9669; Janko, Natasha/0009-0000-5693-0248 FU National Institute on Aging; National Cancer Institute at the National Institutes of Health [U01AG029824, U19AG062682]; NHMRC [334047, 1127060]; Monash University; Victorian Cancer Agency; Monash University, ANZ Trustees; Wicking Trust; Mason Foundation; Abbott Diagnostics; Australian RTP Scholarships; Crohn's and Colitis Australia PhD scholarship; Australian RTP Scholarship; National Health and Medical Research Council (NHMRC) [1127060, 334047] Funding Source: National Health and Medical Research Council (NHMRC) FX The ASPREE clinical trial was supported by the National Institute on Aging and the National Cancer Institute at the National Institutes of Health (U01AG029824, U19AG062682); the NHMRC (334047, 1127060); Monash University; and the Victorian Cancer Agency. The ALSOP was supported by funding from Monash University, ANZ Trustees, the Wicking Trust, and the Mason Foundation. Abbott Diagnostics provided a grant for the measurement of laboratory parameters. I.C. and D.C-C. are supported by Australian RTP Scholarships. J.A.F. is supported by a Crohn's and Colitis Australia PhD scholarship and Australian RTP Scholarship. No funding sources were involved in the design or conduct of the study; collection, management, or analysis of the data; interpretation of the results; preparation, review, or approval of the manuscript; or decision to submit it for publication. 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TI A Gastroenterologist's Approach to Improving Metabolic Health in MASLD SO JOURNAL OF CLINICAL GASTROENTEROLOGY LA English DT Article DE insulin resistance; NAFLD; cardiovascular risk in liver disease; noninvasive liver assessment; lifestyle changes ID NONALCOHOLIC FATTY LIVER; LIFE-STYLE; MEDITERRANEAN DIET; HEPATIC STEATOSIS; ALCOHOL-CONSUMPTION; RISK-FACTORS; WEIGHT-LOSS; DISEASE; METAANALYSIS; PROGRESSION AB Gastroenterologists are often the first to encounter patients with metabolic dysfunction-associated steatotic liver disease (MASLD), the most common chronic liver disease worldwide. While MASLD can lead to cirrhosis and hepatocellular carcinoma, cardiovascular disease (CVD) remains the leading cause of mortality in this population. This heightened risk is largely driven by the strong association between MASLD and CVD risk factors, including type 2 diabetes, obesity, and hypertension. Therefore, addressing metabolic health is a fundamental component of MASLD management. Gastroenterologists play a key role in identifying metabolic risk factors, recommending lifestyle, and pharmacologic interventions, in consultation with specialists or multidisciplinary care teams when appropriate. This review provides a practical framework for integrating metabolic health optimization into routine MASLD care, equipping gastroenterologists with the necessary tools to improve both liver-related and overall patient outcomes. C1 [Abdulrazzak, Eyad] Harvard Med Sch, Beth Israel Deaconess Med Ctr, Dept Med, Boston, MA USA. [Alabdul Razzak, Imad] Phoenixville Hosp, Dept Med, Tower Hlth, Phoenixville, PA USA. [Noureddin, Mazen] Houston Res Inst, Houston, TX USA. [Noureddin, Mazen] Houston Methodist Hosp, Houston, TX USA. [Trivedi, Hirsh D.] Cedars Sinai Med Ctr, Comprehens Transplant Ctr, Los Angeles, CA USA. [Trivedi, Hirsh D.] Cedars Sinai Med Ctr, Karsh Div Gastroenterol, Los Angeles, CA USA. 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Clin. Gastroenterol. PD SEP PY 2025 VL 59 IS 8 BP 713 EP 724 DI 10.1097/MCG.0000000000002210 PG 12 WC Gastroenterology & Hepatology WE Science Citation Index Expanded (SCI-EXPANDED) SC Gastroenterology & Hepatology GA 6BB1W UT WOS:001549102500004 PM 40549660 DA 2026-02-02 ER PT J AU Garcia, S Monserrat-Mesquida, M Ugarriza, L Casares, M Gómez, C Mateos, D Angullo-Martínez, E Tur, JA Bouzas, C AF Garcia, Silvia Monserrat-Mesquida, Margalida Ugarriza, Lucia Casares, Miguel Gomez, Cristina Mateos, David Angullo-Martinez, Escarlata Tur, Josep A. Bouzas, Cristina TI Ultra-Processed Food Consumption and Metabolic-Dysfunction-Associated Steatotic Liver Disease (MASLD): A Longitudinal and Sustainable Analysis SO NUTRIENTS LA English DT Article DE metabolic-dysfunction-associated steatotic liver disease; ultra-processed foods; sustainability; liver fat content; dietary patterns; Mediterranean diet ID PHYSICAL-ACTIVITY QUESTIONNAIRE; MEDITERRANEAN DIET ADHERENCE; FREQUENCY QUESTIONNAIRE; VALIDATION; VALIDITY; OBESITY; HEALTH AB Background: The rising prevalence of metabolic-dysfunction-associated steatotic liver disease (MASLD) is a significant health challenge, and the consumption of ultra-processed foods (UPFs) could play a key role. Aim: The aim is assess the impact of UPF consumption changes on the development and progression of MASLD in adults. Design: This is a longitudinal study to assess how changes in UPF consumption affect liver fat and MASLD parameters over 6 months in 70 participants. Methods: Dietary intake was assessed using a validated food frequency questionnaire, and foods were classified according to the NOVA system. Participants were divided into three groups based on UPF consumption changes: maximum (T1), medium (T2), and minimum reduction (T3). Fatty liver parameters were assessed with magnetic resonance imaging and ultrasonography. Mediterranean diet (Med-diet) adherence and sociodemographic parameters were also recorded. The General Linear Model was used to determine relationships between UPF consumption, fatty liver disease parameters, and diet. Results: Participants in T1 experienced a 7.7% reduction in intrahepatic fat content (IFC) compared to 2.6% in T3. T1 showed increased Med-diet adherence and decreased meat and sweets consumption. The energy intake decreased by 605.3 kcal/day in T1, while T3 showed an increase of 209.5 kcal/day. Conclusions: Reducing UPF consumption leads to a decrease in IFC, associated with high Med-diet adherence and low calorie intake. Adopting these dietary patterns aligns with global sustainability goals and could further benefit MASLD patients by addressing environmental challenges alongside improving liver health. C1 [Garcia, Silvia; Monserrat-Mesquida, Margalida; Ugarriza, Lucia; Gomez, Cristina; Mateos, David; Angullo-Martinez, Escarlata; Tur, Josep A.; Bouzas, Cristina] Univ Balear Isl IUNICS, Res Grp Community Nutr & Oxidat Stress, Palma De Mallorca 07122, Spain. [Garcia, Silvia; Monserrat-Mesquida, Margalida; Ugarriza, Lucia; Gomez, Cristina; Mateos, David; Angullo-Martinez, Escarlata; Tur, Josep A.; Bouzas, Cristina] Hlth Res Inst Balear Isl IdISBa, Palma De Mallorca 07120, Spain. [Garcia, Silvia; Monserrat-Mesquida, Margalida; Ugarriza, Lucia; Mateos, David; Angullo-Martinez, Escarlata; Tur, Josep A.; Bouzas, Cristina] Inst Hlth Carlos III, CIBEROBN Physiopathol Obes & Nutr 30038 CB12 03, Madrid 28029, Spain. [Ugarriza, Lucia] IBSalut, Primary Hlth Care Ctr Camp Redo, Palma de Mallorca 07010, Spain. [Casares, Miguel] Radiodiag Serv, Red Asistencial Juaneda, Palma De Mallorca 07011, Spain. [Gomez, Cristina] Univ Hosp Son Espases, Clin Anal Serv, Palma De Mallorca 07120, Spain. [Mateos, David] Hosp Manacor, Manacor 07500, Spain. [Angullo-Martinez, Escarlata] IBSalut, Primary Hlth Care Ctr Escola Graduada, Palma De Mallorca 07001, Spain. C3 Institut Investigacio Sanitaria Illes Balears (IdISBa); Hospital Universitari Son Espases; Hospital de Manacor RP Tur, JA (通讯作者)，Univ Balear Isl IUNICS, Res Grp Community Nutr & Oxidat Stress, Palma De Mallorca 07122, Spain.; Tur, JA (通讯作者)，Hlth Res Inst Balear Isl IdISBa, Palma De Mallorca 07120, Spain.; Tur, JA (通讯作者)，Inst Hlth Carlos III, CIBEROBN Physiopathol Obes & Nutr 30038 CB12 03, Madrid 28029, Spain. EM silvia.garcia@uib.es; margalida.monserrat@uib.es; cristina.gomez@ssib.es; pep.tur@uib.es; cristina.bouzas@uib.es RI ; Tur, Josep/AAE-5748-2020; Monserrat Mesquida, Margalida/AAB-4773-2019; Bouzas, Cristina/AAE-2069-2019 OI Bouzas Velasco, Cristina/0000-0002-1407-8461; García, Silvia/0000-0003-3534-1588; GOMEZ COBO, CRISTINA/0000-0002-9776-4730; Tur, Josep/0000-0002-6940-0761; Monserrat Mesquida, Margalida/0000-0002-8856-135X; FU Instituto de Salud Carlos III through the Fondo de Investigacion para la Salud [CIBEROBN CB12/03/30038]; European Regional Development Fund; Fundacio La Marato TV3 (Spain) project [201630.10]; IDISBA; Red EXERNET-Red de Ejercicio Fisico y Salud [RED2022-134800-T]; Agencia Estatal de Investigacion (Ministerio de Ciencias e Innovacion, Spain) FX Instituto de Salud Carlos III through the Fondo de Investigacion para la Salud (CIBEROBN CB12/03/30038), which are cofunded by the European Regional Development Fund. Fundacio La Marato TV3 (Spain) project ref. 201630.10. IDISBA Grants (FOLIUM, PRIMUS, SYNERGIA, and LIBERI). Red EXERNET-Red de Ejercicio Fisico y Salud (RED2022-134800-T) Agencia Estatal de Investigacion (Ministerio de Ciencias e Innovacion, Spain). The funding sponsors had no role in the design of this study, in the collection, analyses, or interpretation of the data; in the writing of this manuscript, or in the decision to publish the results. 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German, Ana Gabriela Ayala Herdes, Rachel E. Pai, Nikhil Sierra-Velez, Desiree Whitehead, Bridget Quiros-Tejeira, Ruben E. Duro, Debora TI Evidence-based review of the nutritional treatment of obesity and metabolic dysfunction-associated steatotic liver disease in children and adolescents SO JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION LA English DT Review DE intermittent fasting; ketogenic diet; low-carbohydrate diet; Mediterranean diet; plant-based diet ID NONALCOHOLIC FATTY LIVER; LOW-CARBOHYDRATE DIET; MEDITERRANEAN DIET; KETOGENIC DIET; HEPATIC STEATOSIS; HYPOCALORIC DIET; GLYCEMIC-LOAD; WEIGHT-LOSS; METAANALYSIS; PATTERNS AB The growing pediatric obesity epidemic has paralleled the surge in metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic dysfunction-associated steatohepatitis. It develops due to nutritional imbalances, microbiome dysbiosis, gene regulation, hormonal changes, and environmental factors like food deserts, low activity level, and an unhealthy lifestyle. The prevalence of MASLD and obesity is rising every year. Lifestyle changes remain the mainstay treatment for obesity and MASLD. Per the 2023 American Association for the Study of Liver Diseases Practice Guidance on MASLD, achieving >= 5% weight loss can reduce hepatic steatosis, >= 7% weight loss can reduce hepatic inflammation, and >= 10% weight loss can reduce liver fibrosis. Therefore, nutritional interventions can be a powerful tool to help correct metabolic dysfunction and promote healthy weight loss. Current endorsed nutritional interventions for weight loss or MASLD include the Mediterranean diet, low glycemic/low carbohydrate diet, plant-based diet/anti-inflammatory diet, ketogenic diet, and intermittent fasting. This review provides evidence-based insights into current nutritional interventions for children and adolescents with obesity and MASLD to help guide pediatric gastroenterologists in making the best dietary-based recommendations in clinical practice. C1 [Karjoo, Sara] Johns Hopkins All Childrens Hosp, Dept Pediat, Div Pediat Gastroenterol, St Petersburg, FL 33701 USA. [Karjoo, Sara] Univ S Florida, Tampa, FL USA. [Karjoo, Sara] Florida State Univ, Tallahassee, FL USA. [Braglia-Tarpey, Amy] Amerita Home Infus, Greenwood Village, CO USA. [Chan, Alvin P.] David Geffen Sch Med UCLA, Los Angeles, CA USA. [German, Ana Gabriela Ayala] Inst Mexicano Seguro Social, Unidad Med Alta Especial, Merida, Yucatan, Mexico. [Herdes, Rachel E.] Stanford Univ, Lucile Packard Childrens Hosp, Sch Med, Palo Alto, CA USA. [Pai, Nikhil] Childrens Hosp Philadelphia, Philadelphia, PA USA. [Pai, Nikhil] Univ Penn, Perelman Sch Med, Philadelphia, PA USA. [Pai, Nikhil] McMaster Univ, Hamilton, ON, Canada. [Sierra-Velez, Desiree] Harvard Med Sch, Boston Childrens Hosp, Boston, MA USA. [Whitehead, Bridget] Northwestern Univ, Feinberg Sch Med, Ann & Robert H Lurie Childrens Hosp Chicago, Chicago, IL USA. [Quiros-Tejeira, Ruben E.] Univ Nebraska Med Ctr, Childrens Nebraska, USAN, Omaha, NE USA. [Duro, Debora] Broward Hlth, Salah Fdn Children Hosp, Ft Lauderdale, FL USA. [Duro, Debora] NOVA Southeastern Univ, Ft Lauderdale, FL USA. [Duro, Debora] Florida Int Univ, Miami, FL USA. C3 Johns Hopkins University; Johns Hopkins Medicine; State University System of Florida; University of South Florida; State University System of Florida; Florida State University; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; Instituto Mexicano del Seguro Social; Lucile Packard Children's Hospital (LPCH); Stanford University; University of Pennsylvania; Pennsylvania Medicine; Childrens Hospital of Philadelphia; University of Pennsylvania; McMaster University; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Boston Children's Hospital; Northwestern University; Feinberg School of Medicine; Ann & Robert H. Lurie Children's Hospital of Chicago; University of Nebraska System; University of Nebraska Medical Center; Nova Southeastern University; State University System of Florida; Florida International University RP Karjoo, S (通讯作者)，Johns Hopkins All Childrens Hosp, Dept Pediat, Div Pediat Gastroenterol, St Petersburg, FL 33701 USA. 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Pediatr. Gastroenterol. Nutr. PD SEP PY 2025 VL 81 IS 3 BP 485 EP 496 DI 10.1002/jpn3.70099 EA JUN 2025 PG 12 WC Gastroenterology & Hepatology; Nutrition & Dietetics; Pediatrics WE Science Citation Index Expanded (SCI-EXPANDED) SC Gastroenterology & Hepatology; Nutrition & Dietetics; Pediatrics GA 7BP4Z UT WOS:001509786300001 PM 40525381 DA 2026-02-02 ER PT J AU Torres, JVD Guerrero, VRV Gómez, JPV Miranda, FJP Alvarez, LRO Insignares, JDL Mares, M Ortiz, HMR Mendoza-Torres, E AF Diaz Torres, Janna Vanessa Villanueva Guerrero, Vanessa Rocio Vargas Gomez, Jennifer Patricia Pacheco Miranda, Fredy Javier Orozco Alvarez, Lorena Rocio Leon Insignares, Joseph David Mares, Marian Rodriguez Ortiz, Hector Mario Mendoza-Torres, Evelyn TI Metabolic Dysfunction Associated to Steatotic Liver Disease: A Review SO METABOLIC SYNDROME AND RELATED DISORDERS LA English DT Review DE metabolic dysfunction-associated steatotic liver disease; nonalcoholic fatty liver disease; nonalcoholic steatohepatitis; liver fibrosis ID PRACTICE GUIDANCE; MANAGEMENT; MASLD; RISK AB Metabolic dysfunction-associated steatotic liver disease (MASLD) has replaced the term nonalcoholic fatty liver disease to better reflect its relationship with metabolic dysfunction without creating stigma. MASLD is defined by the presence of hepatic steatosis associated with risk factors, such as type 2 diabetes and overweight/obesity, without the need to exclude other causes of chronic liver disease. The global prevalence of MASLD is high, having an impact in more than one-third of the world's population, particularly in adults with overweight or obesity. When we talk about gender, it is more common in men than in women. MASLD is a complex disorder resulting from the interaction of environmental, genetic, and epigenetic factors, which leads to the dysregulation of lipid metabolism and liver accumulation of fatty acids. MASLD could be diagnosed through imaging methods and serological biomarkers. Elastography and magnetic resonance imaging are the most precise techniques for evaluating liver fibrosis. The treatment focuses on lifestyle modification, which involves weight loss, regular exercise, and a balanced diet. The Mediterranean diet and coffee consumption also have beneficial effects. Several pharmacological therapies are currently being studied, with promising results reported to date. This review aims to provide a comprehensive clinical overview of MASLD, laying the groundwork for understanding the change in nomenclature and becoming familiar with the new term, diagnosis, and treatment. C1 [Diaz Torres, Janna Vanessa; Villanueva Guerrero, Vanessa Rocio; Vargas Gomez, Jennifer Patricia; Pacheco Miranda, Fredy Javier; Orozco Alvarez, Lorena Rocio] Univ Libre, Fac Hlth Exact & Natural Sci, Internal Med Program, Barranquilla, Colombia. [Leon Insignares, Joseph David; Rodriguez Ortiz, Hector Mario; Mendoza-Torres, Evelyn] Univ Libre, Fac Hlth Exact & Natural Sci, Grp Invest Avanzada Biomed, Km 7 Via Antigua Puerto Colombia, Barranquilla 081008, Colombia. [Mares, Marian] Univ Guadalajara, Guadalajara, Mexico. C3 Universidad de Guadalajara RP Mendoza-Torres, E (通讯作者)，Univ Libre, Fac Hlth Exact & Natural Sci, Grp Invest Avanzada Biomed, Km 7 Via Antigua Puerto Colombia, Barranquilla 081008, Colombia. 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PD DEC 1 PY 2025 VL 23 IS 10 BP 427 EP 439 DI 10.1177/15578518251382048 EA SEP 2025 PG 13 WC Medicine, Research & Experimental WE Science Citation Index Expanded (SCI-EXPANDED) SC Research & Experimental Medicine GA M2362 UT WOS:001582953600001 PM 41020710 DA 2026-02-02 ER PT J AU Sandireddy, R Sakthivel, S Gupta, P Behari, J Tripathi, M Singh, BK AF Sandireddy, Reddemma Sakthivel, Suganya Gupta, Priyanka Behari, Jatin Tripathi, Madhulika Singh, Brijesh Kumar TI Systemic impacts of metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic dysfunction-associated steatohepatitis (MASH) on heart, muscle, and kidney related diseases SO FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY LA English DT Review DE Adipose tissue (AT); metabolic dysfunction-associated steatotic liver disease (MASLD)/non-alcoholic fatty liver disease (NAFLD); metabolic dysfunction-associated steatohepatitis (MASH)/non-alcoholic steatohepatitis (NASH); cardiovascular diseases (CVDs); sarcopenia; chronic kidney diseases (CKDs); heart; muscle ID CORONARY MICROVASCULAR DYSFUNCTION; MYOCARDIAL TRIGLYCERIDE CONTENT; PRESERVED EJECTION FRACTION; GAMMA-GLUTAMYL-TRANSFERASE; GROWTH-FACTOR 21; SKELETAL-MUSCLE; INSULIN-RESISTANCE; NONALCOHOLIC STEATOHEPATITIS; CARDIOVASCULAR-DISEASE; MEDITERRANEAN DIET AB Metabolic dysfunction-associated steatotic liver disease (MASLD), previously known as non-alcoholic fatty liver disease (NAFLD), is the most common liver disorder worldwide, with an estimated global prevalence of more than 31%. Metabolic dysfunction-associated steatohepatitis (MASH), formerly known as non-alcoholic steatohepatitis (NASH), is a progressive form of MASLD characterized by hepatic steatosis, inflammation, and fibrosis. This review aims to provide a comprehensive analysis of the extrahepatic manifestations of MASH, focusing on chronic diseases related to the cardiovascular, muscular, and renal systems. A systematic review of published studies and literature was conducted to summarize the findings related to the systemic impacts of MASLD and MASH. The review focused on the association of MASLD and MASH with metabolic comorbidities, cardiovascular mortality, sarcopenia, and chronic kidney disease. Mechanistic insights into the concept of lipotoxic inflammatory "spill over" from the MASH-affected liver were also explored. MASLD and MASH are highly associated (50%-80%) with other metabolic comorbidities such as impaired insulin response, type 2 diabetes, dyslipidemia, hypertriglyceridemia, and hypertension. Furthermore, more than 90% of obese patients with type 2 diabetes have MASH. Data suggest that in middle-aged individuals (especially those aged 45-54), MASLD is an independent risk factor for cardiovascular mortality, sarcopenia, and chronic kidney disease. The concept of lipotoxic inflammatory "spill over" from the MASH-affected liver plays a crucial role in mediating the systemic pathological effects observed. Understanding the multifaceted impact of MASH on the heart, muscle, and kidney is crucial for early detection and risk stratification. This knowledge is also timely for implementing comprehensive disease management strategies addressing multi-organ involvement in MASH pathogenesis. C1 [Sandireddy, Reddemma; Sakthivel, Suganya; Gupta, Priyanka; Behari, Jatin; Tripathi, Madhulika; Singh, Brijesh Kumar] Duke NUS Med Sch, Cardiovasc & Metab Disorders Res Program, Singapore City, Singapore. C3 National University of Singapore RP Tripathi, M; Singh, BK (通讯作者)，Duke NUS Med Sch, Cardiovasc & Metab Disorders Res Program, Singapore City, Singapore. EM singhbrijeshk@duke-nus.edu.sg; singhbrijeshk@hotmail.com RI Singh, Brijesh/C-1093-2009; Behari, Jatin/OAJ-4440-2025 OI Gupta, Priyanka/0000-0002-0919-7757; FU Ministry of Health (MOH); National Medical Research Council (NMRC), Singapore [NMRC/OFYIRG/0002/2016, MOH-000319, MOH-OFIRG19may-0002]; National Medical Research Council (NMRC), Singapore [Duke/Duke-NUS/RECA(Pilot)/2022/0060, Duke-NUS-KBrFA/2023/0075, NMRC/OFYIRG/077/2018]; Duke/Duke-NUS Research Collaboration Pilot Project Award FX The authors like to acknowledge that the research is funded by the Ministry of Health (MOH), and National Medical Research Council (NMRC), Singapore, grant number NMRC/OFYIRG/0002/2016 and MOH-000319 (MOH-OFIRG19may-0002), Duke/Duke-NUS Research Collaboration Pilot Project Award (Duke/Duke-NUS/RECA(Pilot)/2022/0060), and KBrFA (Duke-NUS-KBrFA/2023/0075) to BKS and NMRC/OFYIRG/077/2018 to MT. 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PI LAUSANNE PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND SN 2296-634X J9 FRONT CELL DEV BIOL JI Front. Cell. Dev. Biol. PD JUL 16 PY 2024 VL 12 AR 1433857 DI 10.3389/fcell.2024.1433857 PG 18 WC Cell Biology; Developmental Biology WE Science Citation Index Expanded (SCI-EXPANDED) SC Cell Biology; Developmental Biology GA ZZ3V7 UT WOS:001279077700001 PM 39086662 OA Green Submitted, gold HC Y HP N DA 2026-02-02 ER PT J AU Wang, ZX Chen, G Sun, XT Xiao, J Kong, LL Jiang, SS Xu, TT Wang, MJ Zhao, H AF Wang, Zixuan Chen, Ge Sun, Xutong Xiao, Jia Kong, Lingling Jiang, Shunshun Xu, Tingting Wang, Meijiao Zhao, Hong TI Multi-omics integration reveals the impact of mediterranean diet on hepatic metabolism and gut microbiota in mice with metabolic dysfunction-associated steatotic liver disease SO FRONTIERS IN NUTRITION LA English DT Article DE metabolic dysfunction-associated steatotic liver disease; mediterranean diet; dietary intervention; hepatic metabolism; gut microbiota; omics analysis AB Objective To investigate the effects of the Mediterranean diet (MD) on hepatic metabolism and gut microbiota in mice with metabolic dysfunction-associated steatotic liver disease (MASLD). Methods C57BL/6 mice were fed a high-fat diet for 12 weeks to induce MASLD, with normal chow (NC)-fed mice as controls. Post-modeling, MASLD mice were randomized into three groups: HF (continued high-fat diet), HF-NC (switched to normal chow), and HF-MD (switched to MD). After 18-week interventions, body/liver weights, serum liver enzymes (ALT, AST), hepatic glycolipid markers (glucose, TC, TG, IBIL, DBIL), inflammatory cytokines (IL-6, TNF-alpha; ELISA), and histopathology (H&E and Oil Red O staining) were analyzed. Gut microbiota (metagenomic sequencing) and short-chain fatty acids (SCFAs; targeted metabolomics) were profiled. Results High-fat diet induced MASLD features including obesity, increased abdominal fat mass, hepatic steatosis with lipid droplets, and inflammation. Both HF-NC and HF-MD groups exhibited reduced body weight, liver index, hepatic cytokines, serum enzymes, and improved glucolipid profiles vs. HF group (p < 0.05), with histopathology confirming attenuated steatosis. HF-MD outperformed HF-NC in lowering ALT, AST, IL-6, and TNF-alpha (p < 0.05). MASLD mice showed gut dysbiosis characterized by decreased diversity, elevated Alistipes, Helicobacter, Mucispirillum, and Chlamydia, reduced SCFAs, and increased branched-chain fatty acids (BCFAs) (p < 0.05). Both dietary interventions partially ameliorated gut dysbiosis in MASLD mice, with the HF-MD group uniquely enriching beneficial taxa including Prevotella, Muribaculum, Duncaniella, and Barnesiella. Conclusion MD alleviates MASLD progression by synergistically improving hepatic metabolic homeostasis and gut microbiota composition, demonstrating superior efficacy over NC in mitigating inflammation, enriching beneficial microbes, and regulating microbial metabolism. These findings highlight MD's potential as a targeted dietary intervention for MASLD. C1 [Wang, Zixuan; Wang, Meijiao] Qingdao Univ, Qingdao Med Coll, Qingdao, Peoples R China. [Wang, Zixuan; Chen, Ge; Sun, Xutong; Xiao, Jia; Kong, Lingling; Jiang, Shunshun; Xu, Tingting; Wang, Meijiao; Zhao, Hong] Univ Hlth & Rehabil Sci, Qingdao Cent Hosp, Dept Gastroenterol, Qingdao, Peoples R China. C3 Qingdao University; University of Health & Rehabilitation Sciences RP Zhao, H (通讯作者)，Univ Hlth & Rehabil Sci, Qingdao Cent Hosp, Dept Gastroenterol, Qingdao, Peoples R China. EM zhaohong1968qd@163.com FU National Natural Science Foundation of China [31800660]; Qingdao City Medical and Health Research Program [2024-WJKY058]; Qingdao City Medical and Health Key Discipline Development Project FX We are truly grateful to Qingdao University for supplying the essential experimental facilities and equipment that were vital to this study. 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Nutr. PD AUG 12 PY 2025 VL 12 AR 1644014 DI 10.3389/fnut.2025.1644014 PG 20 WC Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Nutrition & Dietetics GA 6PF2I UT WOS:001558726600001 PM 40873449 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Kwon, YJ Choi, JE Hong, KW Lee, JW AF Kwon, Yu-Jin Choi, Ja-Eun Hong, Kyung-Won Lee, Ji-Won TI Interplay of Mediterranean-diet adherence, genetic factors, and metabolic dysfunction-associated steatotic liver disease risk in Korea SO JOURNAL OF TRANSLATIONAL MEDICINE LA English DT Article DE Mediterranean diet; Metabolic dysfunction-associated fatty liver disease; Gene-diet interaction; Glucokinase regulatory protein gene ID FATTY LIVER; TRIGLYCERIDE; VALIDATION; OBESITY; LOCI; GCKR AB Backgrounds Metabolic dysfunction-associated steatotic liver disease (MASLD) has gained attention owing to its severe complications. This study aimed to explore the interaction between Mediterranean-diet (MD) adherence, genetic factors, and MASLD risk in a Korean population. Methods In total, 33,133 individuals aged 40 years and older from the Korean Genome and Epidemiology Study (KoGES) were analyzed. Participants were assessed for MASLD based on criteria and MD adherence measured by the Korean version of the Mediterranean-Diet Adherence Screener (K-MEDAS). Individuals were categorized into two groups based on their MD adherence: high adherence (K-MEDAS > 6) and low adherence (K-MEDAS < 5). Single nucleotide polymorphism (SNP) genotypes were obtained using the Korea Biobank array. Logistic regression was used to examine the single-marker variants for genetic associations with MASLD prevalence. Results Individuals were categorized into MASLD (10,018 [30.2%]) and non-MASLD (23,115 [69.8%]) groups. A significant interaction was observed between the rs780094 glucokinase regulatory protein (GCKR) gene and K-MEDAS on MASLD (p < 10(-2)). Of individuals with K-MEDAS > 6, those carrying the minor allele (C) of the GCKR gene rs780094 exhibited a lower risk of MASLD compared to those without the allele (odds ratio [OR] = 0.88 [0.85-0.91], p-value = 5.54e-13). Conclusion The study identified a significant interaction involving the rs780094 variant near the GCKR gene, with carriers of the minor allele exhibiting a lower MASLD risk among those adhering well to the MD. Dietary habits influence the MASLD risk associated with the rs780094 allele, emphasizing the need for personalized nutrition recommendations. C1 [Kwon, Yu-Jin] Yonsei Univ, Coll Med, Yongin Severance Hosp, Dept Family Med, 363 Dongbaekjukjeon Daero, Yongin 16995, Gyeonggido, South Korea. [Choi, Ja-Eun; Hong, Kyung-Won] Theragen Hlth Co Ltd, Inst Adv Technol, Pangyoyeok Ro, Seongnam 13493, Gyeonggido, South Korea. [Lee, Ji-Won] Yonsei Univ, Coll Med, Severance Hosp, Dept Family Med, Yonsei Ro 50-1, Seoul 03722, South Korea. [Lee, Ji-Won] Yonsei Univ, Inst Innovat Digital Healthcare, Yonsei Ro 50-1, Seoul 03722, South Korea. C3 Yonsei University; Yonsei University Health System; Yonsei University; Yonsei University Health System; Yonsei University RP Hong, KW (通讯作者)，Theragen Hlth Co Ltd, Inst Adv Technol, Pangyoyeok Ro, Seongnam 13493, Gyeonggido, South Korea.; Lee, JW (通讯作者)，Yonsei Univ, Coll Med, Severance Hosp, Dept Family Med, Yonsei Ro 50-1, Seoul 03722, South Korea.; Lee, JW (通讯作者)，Yonsei Univ, Inst Innovat Digital Healthcare, Yonsei Ro 50-1, Seoul 03722, South Korea. EM kyungwon.hong@theragenhealth.com; indi5645@yuhs.ac RI KWON, YUJIN/ACB-8082-2022 OI KWON, YUJIN/0000-0002-9021-3856; LEE, JI WON/0000-0002-2666-4249 FU Korea Institute of Planning and Evaluation for Technology in Food, Agriculture, and Forestry (IPET ) - Ministry of Agriculture, Food, and Rural Affairs (MAFRA) [321030051HD030]; National Research Foundation of Korea (NRF) - Korea government (MSIT ) [RS-2024-00354524] FX This research was supported by the Korea Institute of Planning and Evaluation for Technology in Food, Agriculture, and Forestry (IPET ) through a high-value-added food technology development program funded by the Ministry of Agriculture, Food, and Rural Affairs (MAFRA) (321030051HD030) and was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT ) (RS-2024-00354524) CR Ahn Y, 2007, EUR J CLIN NUTR, V61, P1435, DOI 10.1038/sj.ejcn.1602657 Amer Diabet Assoc, 2020, DIABETES CARE, V43, pS14, DOI 10.2337/dc20-S002 [Anonymous], 2016, DIABETOLOGIA, V59, P1121, DOI DOI 10.1007/S00125-016-3902-Y Ashcroft FM, 2023, TRENDS ENDOCRIN MET, V34, DOI 10.1016/j.tem.2022.12.007 Bi M, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0011690 Dancause KN, 2020, LANCET REG HEALTH-W, V4, DOI 10.1016/j.lanwpc.2020.100040 Eslam M, 2020, J HEPATOL, V73, P202, DOI 10.1016/j.jhep.2020.03.039 Estruch R, 2018, NEW ENGL J MED, V378, DOI [10.1056/NEJMoa1200303, 10.1056/NEJMoa1800389, 10.1056/nejmoa1800389] Ford BE, 2023, MOL METAB, V72, DOI 10.1016/j.molmet.2023.101722 Gofton C, 2023, CLIN MOL HEPATOL, V29, pS17, DOI 10.3350/cmh.2022.0367 Kim JH, 2011, LIVER INT, V31, P1600, DOI 10.1111/j.1478-3231.2011.02580.x Kim KK, 2023, J OBES METAB SYNDR, V32, P1, DOI 10.7570/jomes23016 Kim Y, 2017, INT J EPIDEMIOL, V46, DOI 10.1093/ije/dyv316 Kwon YJ, 2020, NUTRIENTS, V12, DOI 10.3390/nu12041102 Lee H, 2022, CLIN TRANSL GASTROEN, V13, DOI 10.14309/ctg.0000000000000435 Lin YC, 2014, AM J CLIN NUTR, V99, P869, DOI 10.3945/ajcn.113.079749 Machado MV, 2013, J HEPATOL, V58, P1007, DOI 10.1016/j.jhep.2012.11.021 Mantovani A, 2020, METABOLISM, V111, DOI 10.1016/j.metabol.2020.154170 Mente A, 2009, ARCH INTERN MED, V169, P659, DOI 10.1001/archinternmed.2009.38 Meroni M, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21082986 Mohammadi S, 2020, BMC RES NOTES, V13, DOI 10.1186/s13104-020-4891-y Moon S, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-018-37832-9 Muniyappa R, 2008, AM J PHYSIOL-ENDOC M, V294, pE15, DOI 10.1152/ajpendo.00645.2007 Nettleton JA, 2010, DIABETES CARE, V33, P2684, DOI 10.2337/dc10-1150 Noubiap JJ, 2022, DIABETES RES CLIN PR, V188, DOI 10.1016/j.diabres.2022.109924 Orho-Melander M, 2008, DIABETES, V57, P3112, DOI 10.2337/db08-0516 Park JM, 2015, SCI REP-UK, V5, DOI 10.1038/srep17395 Perez-Martinez P, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0020555 Pollin TI, 2011, J CLIN ENDOCR METAB, V96, pE1142, DOI 10.1210/jc.2010-2324 Qi Q, 2009, DIABETOLOGIA, V52, P834, DOI 10.1007/s00125-009-1290-2 Rossi M, 2013, DIABETOLOGIA, V56, P2405, DOI 10.1007/s00125-013-3013-y Saxena R, 2007, SCIENCE, V316, P1331, DOI 10.1126/science.1142358 Schwingshackl L, 2015, PUBLIC HEALTH NUTR, V18, P1292, DOI 10.1017/S1368980014001542 Silva LF, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-46750-3 Slosberg ED, 2001, DIABETES, V50, P1813, DOI 10.2337/diabetes.50.8.1813 Sofi F, 2008, BMJ-BRIT MED J, V337, DOI 10.1136/bmj.a1344 Teng MLP, 2023, CLIN MOL HEPATOL, V29, pS32, DOI 10.3350/cmh.2022.0365 Trichopoulou A, 2014, BMC MED, V12, DOI 10.1186/1741-7015-12-112 Williams B, 2018, J HYPERTENS, V36, P1953, DOI 10.1097/HJH.0000000000001940 Yang YS, 2022, J OBES METAB SYNDR, V31, P169, DOI 10.7570/jomes22024 Zahedi AS, 2023, DIABETOL METAB SYNDR, V15, DOI 10.1186/s13098-023-01079-w Zhang ZQ, 2023, FRONT ENDOCRINOL, V14, DOI 10.3389/fendo.2023.1247611 NR 42 TC 7 Z9 7 U1 0 U2 4 PU BMC PI LONDON PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND EI 1479-5876 J9 J TRANSL MED JI J. Transl. Med. PD JUN 25 PY 2024 VL 22 IS 1 AR 591 DI 10.1186/s12967-024-05408-z PG 10 WC Medicine, Research & Experimental WE Science Citation Index Expanded (SCI-EXPANDED) SC Research & Experimental Medicine GA WK6L9 UT WOS:001254801800001 PM 38918799 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Tatoli, R Caterina, B Donghia, R Pesole, PL Fontana, L Giannelli, G AF Tatoli, Rossella Caterina, Bonfiglio Donghia, Rossella Pesole, Pasqua Letizia Fontana, Luigi Giannelli, Gianluigi TI Dietary Omega-3 Fatty Acids from Fish and Risk of Metabolic Dysfunction-Associated Steatotic Liver Disease in a Mediterranean Population: Findings from the NUTRIHEP Cohort SO NUTRIENTS LA English DT Article DE MASLD; omega-3 fatty acids; DHA; EPA ID POLYUNSATURATED FATTY-ACIDS; DOCOSAHEXAENOIC ACID; OMEGA-3; EPIDEMIOLOGY; NAFLD; RATIO; MODEL AB Background: Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) is linked to metabolic syndrome, obesity, and type 2 diabetes. Omega-3 fatty acids, especially EPA and DHA from fish, may protect against hepatic steatosis. Methods: From 2015 to 2018, all participants were invited to the first follow-up, where 1426 (62% response rate) responded and underwent the same standardized protocol as at baseline. For this analysis, the study is a cross-sectional investigation focusing solely on follow-up data, which included 1297 adults. MASLD was diagnosed via standardized ultrasound, and dietary intake was assessed using the validated EPIC Food Frequency Questionnaire. Associations between total EPA and DHA intake and MASLD were examined using logistic regression models adjusted for age, sex, marital status, occupation, income, Mediterranean diet adherence, liver enzymes, and C-reactive protein. Results: Overall, 48.5% of participants had MASLD. Higher total EPA and DHA intake was associated with lower odds of MASLD (EPA highest vs. lowest quartile: OR = 0.572, 95% CI 0.400-0.818; DHA highest vs. lowest quartile: OR = 0.516, 95% CI 0.361-0.739). Intake of fatty fish contributed most strongly to this protective effect (EPA highest vs. lowest quartile: OR = 0.556, 95% CI 0.390-0.794; DHA highest vs. lowest quartile: OR = 0.575, 95% CI 0.403-0.820), whereas mollusks, crustaceans, and some processed/frozen fish showed weaker or no associations. A statistically significant trend of decreasing MASLD risk was observed across increasing quartiles of both EPA and DHA intake. Conclusions: Higher intake of EPA and DHA, especially from fatty fish, is linked to lower MASLD risk in this Mediterranean population, supporting recommendations for regular fish consumption to protect liver health. C1 [Tatoli, Rossella; Caterina, Bonfiglio; Donghia, Rossella] Natl Inst Gastroenterol IRCCS Saverio de Bellis, Unit Data Sci, I-70013 Bari, Italy. [Pesole, Pasqua Letizia] Natl Inst Gastroenterol IRCCS Saverio de Bellis, Core Facil Biobank, I-70013 Bari, Italy. [Fontana, Luigi] Univ Sydney, Fac Med & Hlth, Charles Perkins Ctr, Sydney, NSW 2006, Australia. [Fontana, Luigi] Royal Prince Alfred Hosp, Dept Endocrinol, Sydney, NSW 2050, Australia. [Giannelli, Gianluigi] Natl Inst Gastroenterol IRCCS Saverio de Bellis, Sci Direct, I-70013 Bari, Italy. C3 IRCCS Saverio de Bellis; IRCCS Saverio de Bellis; University of Sydney; University of Sydney; NSW Health; Royal Prince Alfred Hospital; IRCCS Saverio de Bellis RP Tatoli, R (通讯作者)，Natl Inst Gastroenterol IRCCS Saverio de Bellis, Unit Data Sci, I-70013 Bari, Italy. EM rossella.tatoli@irccsdebellis.it; catia.bonfiglio@irccsdebellis.it; rossella.donghia@irccsdebellis.it; letizia.pesole@irccsdebellis.it; luigi.fontana@sydney.edu.au; gianluigi.giannelli@irccsdebellis.it RI giannelli, gianluigi/A-8169-2012 OI Bonfiglio, Caterina/0000-0002-8650-348X; Tatoli, Rossella/0000-0002-7891-6057; Donghia, Rossella/0000-0002-9140-673X; pesole, pasqua letizia/0000-0003-4675-2075 FU Italian Ministry of Health through Ricerca Corrente 2025 FX This study was supported by the Italian Ministry of Health through Ricerca Corrente 2025. 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Ibdah, Jamal A. TI Effects of Diet and Exercise on Mitochondrial Health in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD): Role of Ceramides SO NUTRIENTS LA English DT Review DE liver; ceramides; mitochondrial dysfunction; diet; exercise; MASLD ID NONALCOHOLIC FATTY LIVER; HEPATIC INSULIN-RESISTANCE; PERMEABILITY TRANSITION PORE; SKELETAL-MUSCLE CELLS; KINASE-C-ZETA; MEDITERRANEAN DIET; OXIDATIVE STRESS; PHYSICAL-ACTIVITY; RESPIRATORY-CHAIN; LIPID-METABOLISM AB Metabolic dysfunction-associated steatotic liver disease (MASLD) impacts nearly a quarter of the world's population and encompasses a range of disease states, from simple steatosis to more advanced stages like metabolic dysfunction-associated steatohepatitis (MASH), fibrosis, and cirrhosis. A key driver of disease progression is mitochondrial dysfunction, characterized by impaired fatty acid oxidation and an overall decline in mitochondrial health. Emerging evidence has implicated ceramides-bioactive sphingolipids that serve roles in apoptotic pathways and as signals of nutrient excess-as important contributors to this dysfunction. Ceramide accumulation within mitochondria mirrors impairments seen in MASLD, specifically elevations in oxidative stress, disrupted fatty acid oxidation, and impaired mitochondrial dynamics. Ceramides may serve as an important molecular link between nutrient overload and mitochondrial dysfunction in the pathogenesis of MASLD. Given the limited availability of effective pharmacologic therapies for MASLD, lifestyle interventions like dietary modification and physical activity remain the cornerstone of disease management worldwide. In this review, we provide an overview of the current understanding of the role of ceramides in mediating the effects of diet and exercise on MASLD through their influence on mitochondrial health. C1 [McCaffrey, Jonas M.] Univ Missouri, Sch Med, Columbia, MO 65212 USA. [Ibdah, Jamal A.] Univ Missouri, Div Gastroenterol & Hepatol, Columbia, MO 65212 USA. [Ibdah, Jamal A.] Harry S Truman Mem Vet Med Ctr, Columbia, MO 65201 USA. [Ibdah, Jamal A.] Univ Missouri, Dept Med Pharmacol & Physiol, Columbia, MO 65212 USA. [Ibdah, Jamal A.] Univ Missouri, Dept Nutr & Exercise Physiol, Columbia, MO 65212 USA. C3 University of Missouri System; University of Missouri Columbia; University of Missouri System; University of Missouri Columbia; US Department of Veterans Affairs; Veterans Health Administration (VHA); Harry S. Truman Memorial Veterans' Hospital; University of Missouri System; University of Missouri Columbia; University of Missouri System; University of Missouri Columbia RP Ibdah, JA (通讯作者)，Univ Missouri, Div Gastroenterol & Hepatol, Columbia, MO 65212 USA.; Ibdah, JA (通讯作者)，Harry S Truman Mem Vet Med Ctr, Columbia, MO 65201 USA.; Ibdah, JA (通讯作者)，Univ Missouri, Dept Med Pharmacol & Physiol, Columbia, MO 65212 USA.; Ibdah, JA (通讯作者)，Univ Missouri, Dept Nutr & Exercise Physiol, Columbia, MO 65212 USA. EM ibdahj@health.missouri.edu OI Ibdah, Jamal/0000-0002-5646-9014; McCaffrey, Jonas/0000-0003-1029-0913 FU U.S. Department of Veterans Affairs; University of Missouri; [CX002436] FX We acknowledge funding from the U.S. Department of Veterans Affairs CX002436 (JAI) and support from Raymond, E. and Vaona, H. Peck Endowed Chair in Cancer Research (JAI) from University of Missouri. 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TI Two-Year Mediterranean Diet Intervention Improves Hepatic Health in MASLD Patients SO FOODS LA English DT Article DE MASLD; Mediterranean diet; hepatic health; intrahepatic fat content; fatty liver index AB Background: Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) is one of the leading causes of chronic liver disease, affecting 30% of the global adult population and continuing to rise. Objective: We aimed to assess the effect of a two-year follow-up Mediterranean diet intervention on parameters of liver health in MASLD patients. Methods: Sixty-two people between 40 and 60 years of age, all diagnosed with MASLD, were enrolled in the two-year clinical trial, who were randomly assigned to one of three interventions following the Mediterranean diet pattern and the promotion of physical activity. After the intervention, the participants were categorized into two groups according to their progress in adhering to the Mediterranean diet (MedDiet), which was assessed at four follow-up time points, conducted at the start of this study and after 6, 12, and 24 months of intervention. A multivariate general linear model adjusted for age, sex, and intervention (diet and physical activity) was used. Bonferroni's post hoc test identified differences between groups and sessions within the same group. Results: Participants in the highly adherent group showed significantly stronger improvement in anthropometric measures, lipid profile, and liver enzyme levels during the follow-up period, along with a reduction in the Dietary Inflammatory Index, intrahepatic fat content, the fatty liver index, and plasma cytokeratin-18 levels compared to baseline. The progress observed in several parameters at 12 months came to a standstill, likely because of the COVID-19 pandemic at that time. At 24 months, following the COVID-19 pandemic, these parameters improved as a result of better adherence to the Mediterranean diet. Conclusions: Greater adherence to the Mediterranean diet, along with increased physical activity, significantly enhances liver health markers in individuals with MASLD. These findings support the Mediterranean lifestyle as an effective non-pharmacological strategy to improve liver health and prevent liver-related complications in MASLD patients, potentially reducing the future public health burden. C1 [Monserrat-Mesquida, Margalida; Bouzas, Cristina; Garcia, Silvia; Mateos, David; Ugarriza, Lucia; Gomez, Cristina; Sureda, Antoni; Tur, Josep A.] Univ Balear Isl, Res Grp Community Nutr & Oxidat Stress, IUNICS, Palma De Mallorca 07122, Spain. [Monserrat-Mesquida, Margalida; Bouzas, Cristina; Garcia, Silvia; Mateos, David; Ugarriza, Lucia; Gomez, Cristina; Sureda, Antoni; Tur, Josep A.] Hlth Res Inst Balear Isl IdISBa, Palma De Mallorca 07120, Spain. [Monserrat-Mesquida, Margalida; Bouzas, Cristina; Ugarriza, Lucia; Gomez, Cristina; Sureda, Antoni; Tur, Josep A.] Inst Salud Carlos III ISCIII, CIBER Fisiopatol Obesidad & Nutr CIBEROBN, Madrid 28029, Spain. [Casares, Miguel] Red Asistencial Juaneda, Radiodiag Serv, Palma De Mallorca 07011, Spain. [Ugarriza, Lucia] IBSalut, CS Camp Redo, Palma De Mallorca 07010, Spain. [Gomez, Cristina] Univ Hosp Son Espases, Clin Anal Serv, Palma De Mallorca 07120, Spain. C3 Universitat de les Illes Balears; IUNICS; Institut Investigacio Sanitaria Illes Balears (IdISBa); CIBER - Centro de Investigacion Biomedica en Red; CIBEROBN; Hospital Universitari Son Espases RP Tur, JA (通讯作者)，Univ Balear Isl, Res Grp Community Nutr & Oxidat Stress, IUNICS, Palma De Mallorca 07122, Spain.; Tur, JA (通讯作者)，Hlth Res Inst Balear Isl IdISBa, Palma De Mallorca 07120, Spain.; Tur, JA (通讯作者)，Inst Salud Carlos III ISCIII, CIBER Fisiopatol Obesidad & Nutr CIBEROBN, Madrid 28029, Spain. EM margalida.monserrat@uib.es; cristina.bouzas@uib.es; cristina.gomez@ssib.es; pep.tur@uib.es RI ; Monserrat Mesquida, Margalida/AAB-4773-2019; Tur, Josep/AAE-5748-2020; Bouzas, Cristina/AAE-2069-2019; Sureda, Antoni/N-9588-2019 OI , Antoni/0000-0001-8656-6838; GOMEZ COBO, CRISTINA/0000-0002-9776-4730; Monserrat Mesquida, Margalida/0000-0002-8856-135X; Tur, Josep/0000-0002-6940-0761; García, Silvia/0000-0003-3534-1588; Bouzas Velasco, Cristina/0000-0002-1407-8461; FU Fundacio La Marato TV3 (Spain) [201630.10]; Instituto de Salud Carlos III through the Fondo de Investigacion para la Salud - European Regional Development Fund [CIBEROBN CB12/03/30038]; IDISBA Grant (FOLIUM); IDISBA Grant (PRIMUS); IDISBA Grant (SYNERGIA); IDISBA Grant (LIBERI); FOLIUM-IDISBA post-doctoral grant FX Fundacio La Marato TV3 (Spain) project ref. 201630.10. 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Moreover, its manipulation is being investigated as a potential therapeutic strategy. In this narrative review we will dissect the involvement of the gut microbiota and of the gut-liver axis on metabolic dysfunction- associated steatotic liver disease (MASLD). Additionally, we will review the effects of lifestyle interventions commonly used for MASLD (i.e. Mediterranean diet and physical exercise) on gut microbiome, to understand if their beneficial effect can be microbially mediated. Finally, we will discuss the role and the available evidence of therapeutic microbiome modulators, including prebiotics, probiotics, symbiotics, and fecal microbiota transplantation (FMT), in the management of MASLD. C1 [Garcia-Mateo, Sandra; Lanas, Angel; Gomollon, Fernando] Lozano Blesa Clin Hosp, Dept Gastroenterol, Zaragoza 50009, Spain. [Garcia-Mateo, Sandra; Lanas, Angel; Gomollon, Fernando] Aragon Hlth Res Inst IIS Aragon, Zaragoza 50009, Spain. [Garcia-Mateo, Sandra; Lanas, Angel; Gomollon, Fernando] Univ Zaragoza, Sch Med, Zaragoza 50009, Spain. [Rondinella, Debora; Ponziani, Francesca Romana; Miele, Luca; Gasbarrini, Antonio; Cammarota, Giovanni] Univ Cattolica Sacro Cuore, Dept Translat Med & Surg, Rome, Italy. [Rondinella, Debora; Ponziani, Francesca Romana; Miele, Luca; Gasbarrini, Antonio; Cammarota, Giovanni] Fdn Policlin Univ Agostino Gemelli IRCCS, Dept Med & Surg Sci, UOC Gastroenterol, Rome, Italy. [Rondinella, Debora; Ponziani, Francesca Romana; Miele, Luca; Gasbarrini, Antonio; Cammarota, Giovanni] Fdn Policlin Univ Gemelli IRCCS, UOC CEMAD Ctr Malattie Apparato Digerente Med Inte, Dept Med & Surg Sci, Rome, Italy. C3 Lozano Blesa University Clinical Hospital; University of Zaragoza; Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli; Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli; Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli RP Garcia-Mateo, S (通讯作者)，Av San Juan Bosco 15, Zaragoza 50009, Spain. EM sgarciamateo7@gmail.com RI ; Miele, Luca/C-2255-2015; Gasbarrini, Antonio/AAB-8487-2019; Cammarota, Giovanni/AAD-1732-2022; Ponziani, Francesca Romana/E-4136-2016 OI García-Mateo, Sana/0000-0002-2670-3922; FU Italian Ministry of Health [GR-2018-12365734]; Fondo Italiano per la Scienza 2021 of the Italian Ministry of University [FIS_00001711]; Italian Ministry of Research [RF-2016-02362055] FX This work was supported by the Ricerca Finalizzata Giovani Ricer-catori 2018 of the Italian Ministry of Health (project GR-2018-12365734) and by the Fondo Italiano per la Scienza 2021 of the Italian Ministry of University and Research (project FIS_00001711) to GI; by the BIOMIS grant of the Italian Ministry of Research to AG, GC, and GI; by the Ricerca Finalizzata 2016 of the Italian Ministry of Health (project RF-2016-02362055) to GC. The funders had no role in any decision to publish or prepare the manuscript. 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Res. Clin. Gastroenterol. PD SEP PY 2024 VL 72 AR 101924 DI 10.1016/j.bpg.2024.101924 EA DEC 2024 PG 11 WC Gastroenterology & Hepatology WE Science Citation Index Expanded (SCI-EXPANDED) SC Gastroenterology & Hepatology GA T8B6K UT WOS:001407196100001 PM 39645278 DA 2026-02-02 ER PT J AU Xu, M Zhan, YM Gao, GH Zhu, L Wu, T Xin, GJ AF Xu, Min Zhan, Yamei Gao, Guohui Zhu, Li Wu, Tong Xin, Guijie TI Associations of five dietary indices with metabolic dysfunction-associated steatotic liver disease and liver fibrosis among the United States population SO FRONTIERS IN NUTRITION LA English DT Article DE MASLD; NAFLD; NHANES; dietary index; liver fibrosis ID FATTY LIVER; INDIVIDUALS; PREVALENCE; NAFLD; RISK AB Background and aims The role of dietary factors in metabolic dysfunction-associated steatotic liver disease (MASLD)-which represents a new definition of liver steatosis and metabolic dysfunction- remains unclear. This study aimed to explore the relationships between dietary indices and MASLD.Methods We analyzed data from the United States National Health and Nutrition Examination Survey (NHANES) 2017-2020 cycle, including 4,690 participants with complete vibration-controlled transient elastography (VCTE) data. Multivariate logistic regression models adjusted for covariates were used to assess the association between dietary indices, MASLD, and MASLD-associated liver fibrosis (MASLD-LF). Restricted cubic spline (RCS) models and subgroup analyses were also performed.Results The Alternative Healthy Eating Index (AHEI), Healthy Eating Index-2020 (HEI-2020), Dietary Approaches to Stop Hypertension Index (DASHI), and Mediterranean Diet Index (MEDI) were found to be negatively associated with MASLD risk, while the Dietary Inflammatory Index (DII) had a positive association. The highest quartile of MEDI was linked to a 44% reduction in MASLD risk [Q1 vs. Q4 odds ratio (OR): 0.56; 95% confidence interval (CI): 0.34-0.94, P for trend: 0.012]. DASHI was uniquely associated with a reduced risk of MASLD-LF (continuous OR: 0.79; 95% CI: 0.64-0.97; p for trend: 0.003). Our RCS curves indicated a nonlinear association with DASHI-MASLD (p-overall: 0.0001, p-nonlinear: 0.0066). Subgroup analyses showed robust associations among the non-Hispanic White and highly educated populations.Conclusion Specific dietary patterns were associated with reduced risks of MASLD and MASLD-LF. The DASHI, in particular, showed a significant protective effect against MASLD-LF. These findings suggest potential dietary interventions for managing MASLD and MASLD-LF, although large-scale randomized controlled trials are warranted to validate these findings. C1 [Xu, Min; Gao, Guohui; Zhu, Li; Wu, Tong; Xin, Guijie] First Hosp Jilin Univ, Ctr Infect Dis & Pathogen Biol, Dept Hepatol, Changchun, Peoples R China. [Zhan, Yamei] First Hosp Jilin Univ, Dept Nephrol, Changchun, Peoples R China. C3 Jilin University; Jilin University RP Wu, T; Xin, GJ (通讯作者)，First Hosp Jilin Univ, Ctr Infect Dis & Pathogen Biol, Dept Hepatol, Changchun, Peoples R China. EM wutongoo@163.com; xingj@jlu.edu.cn OI Xu, Min/0009-0009-8247-2418 FU Health and Health Innovation Program of Jilin Province [2018 J043] FX The author(s) declare that financial support was received for the research, authorship, and/or publication of this article. This study was supported by the Health and Health Innovation Program of Jilin Province under Grant no. 2018 J043. 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Nutr. PD AUG 16 PY 2024 VL 11 AR 1446694 DI 10.3389/fnut.2024.1446694 PG 12 WC Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Nutrition & Dietetics GA E3M9P UT WOS:001302092800001 PM 39221157 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Wang, K Xiang, SJ He, QS Liu, AR Huang, CM Yang, Z Li, RJ Hu, JX Cai, RS Mi, NN Liang, ZX Xu, ZF Yuan, JQ Xia, B AF Wang, Kai Xiang, Shijian He, Qiangsheng Liu, Anran Huang, Chumei Yang, Zhen Li, Renjie Hu, Jiaxin Cai, Ruisheng Mi, Ningning Liang, Zixin Xu, Zuofeng Yuan, Jinqiu Xia, Bin TI Mediterranean diet and associated metabolite signatures in relation to MASLD progression: A prospective cohort study SO HEPATOLOGY COMMUNICATIONS LA English DT Article DE cohort study; mediation effect; Mediterranean diet; metabolic dysfunction-associated steatotic liver disease; metabolomics ID FATTY LIVER-DISEASE; LIFE-STYLE; ADHERENCE; QUALITY; HEALTH; ADULTS; POPULATION; SURVIVAL; BENEFITS AB Background:Mediterranean diet (MED) is recommended for managing metabolic dysfunction-associated steatotic liver disease (MASLD). However, associations between MED adherence, related metabolite signatures, and risks of liver-related events (LRE) and mortality in MASLD patients remain unclear.Methods:We performed a prospective analysis using UK Biobank data, including 47,429 MASLD participants free of LRE at baseline. MED adherence was assessed as alternate Mediterranean Diet (aMED) score through a validated questionnaire. Metabolic biomarkers were measured using high-throughput nucleic magnetic resonance (NMR) spectroscopy. Cox regression and restricted cubic splines assessed the association of aMED, its components, with risk of LRE and mortality. Mediation analysis evaluated the role of metabolites in the relationship between aMED, its components, and MASLD progression.Results:Over a median follow-up of 13.3 years, 296 LRE cases and 3616 deaths occurred. Higher aMED scores (6-9) were associated with lower risks of LRE (HR: 0.553, 95% CI: 0.351-0.874) and mortality (HR: 0.854, 95% CI: 0.762-0.956) compared with the lowest scores (0-3), with linear dose-response relationships. Vegetables and legumes were associated with lower LRE risk, while vegetables, nuts, fish, MUFA:SFA ratio, and moderate alcohol intake were linked to reduced mortality. Of 143 metabolites, 46 were significantly associated with aMED. Omega-3 fatty acids, the omega-3 to total fatty acid ratio, and albumin accounted for 7.9%, 11.9%, and 2.6% of the reduction in LRE, and 19.4%, 23.1%, and 4.7% of the mitigation in mortality, respectively.Conclusions:Adherence to MED is linked to reduced LRE risk and mortality in MASLD patients. Metabolic biomarkers, particularly small HDL particles and omega-3 fatty acids, may mitigate MASLD progression. C1 [Wang, Kai; He, Qiangsheng; Cai, Ruisheng; Liang, Zixin; Yuan, Jinqiu; Xia, Bin] Sun Yat Sen Univ, Affiliated Hosp 7, Clin Big Data Res Ctr, Dept Epidemiol & Biostat, Shenzhen, Guangdong, Peoples R China. [Wang, Kai; He, Qiangsheng; Yuan, Jinqiu; Xia, Bin] Chinese Hlth Risk Management Collaborat, Shenzhen, Guangdong, Peoples R China. [Xiang, Shijian] Sun Yat Sen Univ, Affiliated Hosp 7, Dept Pharm, Shenzhen, Guangdong, Peoples R China. [Liu, Anran; Yang, Zhen] Sun Yat Sen Univ, Affiliated Hosp 7, Clin Nutr Dept, Shenzhen, Guangdong, Peoples R China. [Huang, Chumei] Sun Yat Sen Univ, Affiliated Hosp 7, Ctr Digest Dis, Shenzhen, Guangdong, Peoples R China. [Li, Renjie; Xu, Zuofeng] Sun Yat Sen Univ, Affiliated Hosp 7, Dept Ultrasound, Shenzhen, Guangdong, Peoples R China. [Hu, Jiaxin] Sun Yat Sen Univ, Sch Med, Shenzhen, Guangdong, Peoples R China. [Mi, Ningning] Lanzhou Univ, Sch Clin Med 1, Dept Gen Surg, Lanzhou, Gansu, Peoples R China. C3 Sun Yat Sen University; Sun Yat Sen University; Sun Yat Sen University; Sun Yat Sen University; Sun Yat Sen University; Sun Yat Sen University; Lanzhou University RP Yuan, JQ; Xia, B (通讯作者)，Sun Yat Sen Univ, Affiliated Hosp 7, Clin Big Data Res Ctr, Dept Epidemiol & Biostat, Shenzhen, Guangdong, Peoples R China.; Xu, ZF (通讯作者)，Sun Yat Sen Univ, Affiliated Hosp 7, Dept Ultrasound, Shenzhen, Guangdong, Peoples R China. EM wangk357@mail.sysu.edu.cn; xiangshij3@mail.sysu.edu.cn; heqiangsheng@sysush.com; liuanran@sysush.com; huangchm23@mail.sysu.edu.cn; m18382000631@163.com; lirj58@mail2.sysu.edu.cn; hujx55@mail2.sysu.edu.cn; cairui@sysush.com; minn18@lzu.edu.cn; liangzixin@sysush.com; xuzf@mail.sysu.edu.cn; yuanjq5@mail.sysu.edu.cn; xiab7@mail.sysu.edu.cn RI liu, anran/HTQ-0424-2023; Yuan, Jinqiu/A-4867-2018; Wang, Kai/O-7754-2019 OI He, Qiangsheng/0000-0001-6081-2447 FU Shenzhen Medical Research Fund [A2403069, C2401002]; Funding of Shenzhen Clinical Research Center for Gastroenterology [LCYSSQ20220823091203008]; Natural Science Foundation of China [82103913, 82473707]; Research Supporting Start-up Fund for Associate researcher, of SAHSYSU [ZSQYRSSFAR0004]; Startup Fund for the 100 Top Talents Program, SYSU [392012]; Shenzhen Key Laboratory of Chinese Medicine Active substance screening and Translational Research [ZDSYS20220606100801003] FX This work was supported by the Shenzhen Medical Research Fund (Nos. A2403069, C2401002), the Funding of Shenzhen Clinical Research Center for Gastroenterology (Gastrointestinal Surgery, No. LCYSSQ20220823091203008), the Natural Science Foundation of China(Nos. 82103913, 82473707), the Research Supporting Start-up Fund for Associate researcher, of SAHSYSU(No. ZSQYRSSFAR0004),the Startup Fund for the 100 Top Talents Program, SYSU (No. 392012), and Shenzhen Key Laboratory of Chinese Medicine Active substance screening and Translational Research (No.ZDSYS20220606100801003). 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PD SEP PY 2025 VL 9 IS 9 AR e0791 DI 10.1097/HC9.0000000000000791 PG 14 WC Gastroenterology & Hepatology WE Science Citation Index Expanded (SCI-EXPANDED) SC Gastroenterology & Hepatology GA 6VW4I UT WOS:001563259400001 PM 40879470 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Mambrini, SP Grillo, A Colosimo, S Zarpellon, F Pozzi, G Furlan, D Amodeo, G Bertoli, S AF Mambrini, Sara Paola Grillo, Antonio Colosimo, Santo Zarpellon, Francesco Pozzi, Giorgia Furlan, Davide Amodeo, Gabriele Bertoli, Simona TI Diet and physical exercise as key players to tackle MASLD through improvement of insulin resistance and metabolic flexibility SO FRONTIERS IN NUTRITION LA English DT Review DE MASLD; physical exercise; insulin resistance; metabolic flexibility; Mediterranean diet; resistance exercise ID FATTY-LIVER-DISEASE; PROLIFERATOR-ACTIVATED-RECEPTOR; INCIDENT CARDIOVASCULAR-DISEASE; WHITE ADIPOSE-TISSUE; SHORT-TERM EXERCISE; SKELETAL-MUSCLE; HEPATIC STEATOSIS; WEIGHT-LOSS; FIBER-TYPE; ENERGY-EXPENDITURE AB Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) has emerged as a prevalent health concern, encompassing a wide spectrum of liver-related disorders. Insulin resistance, a key pathophysiological feature of MASLD, can be effectively ameliorated through dietary interventions. The Mediterranean diet, rich in whole grains, fruits, vegetables, legumes, and healthy fats, has shown promising results in improving insulin sensitivity. Several components of the Mediterranean diet, such as monounsaturated fats and polyphenols, exert anti-inflammatory and antioxidant effects, thereby reducing hepatic steatosis and inflammation. Furthermore, this dietary pattern has been associated with a higher likelihood of achieving MASLD remission. In addition to dietary modifications, physical exercise, particularly resistance exercise, plays a crucial role in enhancing metabolic flexibility. Resistance exercise training promotes the utilization of fatty acids as an energy source. It enhances muscle glucose uptake and glycogen storage, thus reducing the burden on the liver to uptake excess blood glucose. Furthermore, resistance exercise stimulates muscle protein synthesis, contributing to an improved muscle-to-fat ratio and overall metabolic health. When implemented synergistically, the Mediterranean diet and resistance exercise can elicit complementary effects in combating MASLD. Combined interventions have demonstrated additive benefits, including greater improvements in insulin resistance, increased metabolic flexibility, and enhanced potential for MASLD remission. This underscores the importance of adopting a multifaceted approach encompassing dietary modifications and regular physical exercise to effectively manage MASLD. This narrative review explores the biological mechanisms of diet and physical exercise in addressing MASLD by targeting insulin resistance and decreased metabolic flexibility. C1 [Mambrini, Sara Paola; Bertoli, Simona] Ist Auxol Italiano IRCCS, Osped S Giuseppe, Nutr Sci Res Lab, Oggebbio, Italy. [Grillo, Antonio; Amodeo, Gabriele] Ist Auxol Italiano IRCCS, Oggebbio, Italy. [Colosimo, Santo; Zarpellon, Francesco; Pozzi, Giorgia; Furlan, Davide; Bertoli, Simona] Univ Milan, Dept Food Environm & Nutr Sci DeFENS, Milan, Italy. [Colosimo, Santo] Univ Milan, PhD Sch Nutr Sci, Milan, Italy. C3 IRCCS Istituto Auxologico Italiano; IRCCS Istituto Auxologico Italiano; University of Milan; University of Milan RP Colosimo, S (通讯作者)，Univ Milan, Dept Food Environm & Nutr Sci DeFENS, Milan, Italy.; Colosimo, S (通讯作者)，Univ Milan, PhD Sch Nutr Sci, Milan, Italy. EM santo.colosimo@unimi.it RI Grilo, Antonio/A-5091-2013; Bertoli, Simona/K-2805-2018; Mambrini, Sara/AAD-1720-2022 FU Italian Ministry of Health - Ricerca Corrente; Fondazione Grigioni per Morbo di Parkinson; NRRP - Next Gen EU FX The author(s) declare that financial support was received for the research, authorship, and/or publication of this article. This work was supported by Italian Ministry of Health - Ricerca Corrente. SC research fellowship was supported by Fondazione Grigioni per Morbo di Parkinson. SC current PhD studentship is supported by NRRP - Next Gen EU. 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Nutr. PD AUG 20 PY 2024 VL 11 AR 1426551 DI 10.3389/fnut.2024.1426551 PG 12 WC Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Nutrition & Dietetics GA E5N3F UT WOS:001303462600001 PM 39229589 OA Green Submitted, gold DA 2026-02-02 ER PT J AU López-Méndez, I Uribe, M Juárez-Hernández, E AF Lopez-Mendez, Ivan Uribe, Misael Juarez-Hernandez, Eva TI Immunonutrition: Another Player on the MASLD Field SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES LA English DT Review DE inflammation; oxidative stress; liver steatosis; nutrition ID FATTY LIVER-DISEASE; CHAIN AMINO-ACIDS; MEDITERRANEAN DIET; INSULIN-RESISTANCE; HEPATIC STEATOSIS; VITAMIN-E; HEALTH; STEATOHEPATITIS; POLYPHENOLS; MODULATION AB Immunonutrition is a nutritional strategy where the bioactive properties of nutrients from the diet are used to modulate metabolic pathways, inflammation signals, and oxidative stress regulators. Metabolic dysfunction-associated steatotic liver disease (MASLD) is a chronic degenerative disease with increasing prevalence over the past decade. In MASLD, where inflammation and oxidative stress play key roles in the progression of liver disease, immunonutrition becomes even more important. The impact of different dietary patterns has been studied in the MASLD context; however, current guidelines emphasize the Mediterranean Diet, which, in terms of included food groups, provides a high level of immunonutrients. Nonetheless, adherence, monitoring, and implementation based on geographic areas, availability, and economic factors make this type of diet ultimately less accessible. The main benefit of the diet pattern is in maintaining the positive effects of new pharmacological treatments, alongside physical activity, which are crucial to prevent recurrence. A diet strategy designed for MASLD needs to be adapted to local food availability and should promote the inclusion of immunonutrients. In the treatment of MASLD, dietary recommendations should be individualized based on the sociodemographic, clinical, and nutritional characteristics of the patients. C1 [Lopez-Mendez, Ivan] Med Sur Clin & Fdn, Hepatol & Transplants Unit, Mexico City 14050, DF, Mexico. [Uribe, Misael] Med Sur Clin & Fdn, Gastroenterol & Obes Unit, Mexico City 14050, DF, Mexico. [Juarez-Hernandez, Eva] Med Sur Clin & Fdn, Translat Res Unit, Mexico City 14050, DF, Mexico. RP López-Méndez, I (通讯作者)，Med Sur Clin & Fdn, Hepatol & Transplants Unit, Mexico City 14050, DF, Mexico.; Juárez-Hernández, E (通讯作者)，Med Sur Clin & Fdn, Translat Res Unit, Mexico City 14050, DF, Mexico. 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PD SEP 13 PY 2025 VL 26 IS 18 AR 8928 DI 10.3390/ijms26188928 PG 26 WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary WE Science Citation Index Expanded (SCI-EXPANDED) SC Biochemistry & Molecular Biology; Chemistry GA 7UR8I UT WOS:001580099400001 PM 41009496 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Sun, KX Li, WT Chen, YA Nelson, EAS Chen, X Hui, LL AF Sun, Kexin Li, Weitian Chen, Yunan Nelson, Edmund Anthony Severn Chen, Xu Hui, Lai Ling TI Ketogenic diets and metabolic dysfunction-associated steatotic liver disease: a literature review SO CELL AND BIOSCIENCE LA English DT Review DE Ketogenic diets; Metabolic dysfunction-associated steatotic liver disease; Liver steatosis; Lipid profile; Inflammation; Gut microbiota ID NONALCOHOLIC FATTY LIVER; CARBOHYDRATE-RESTRICTED DIET; TERM-FOLLOW-UP; WEIGHT-LOSS; INSULIN-RESISTANCE; LONG-TERM; MEDITERRANEAN DIET; HEPATIC STEATOSIS; GUT MICROBIOTA; BETA-HYDROXYBUTYRATE AB Metabolic dysfunction-associated steatotic liver disease (MASLD) is estimated to affect over 30% of the global population with a rising trend, posing significant healthcare burden due to its progression and increased risk of related metabolic diseases. Dietary intervention plays an important role in the prevention and management of MASLD. Ketogenic diets represent a range of high-fat, moderate-protein, very low-carbohydrate (< 20-50 g/day) diets that induce nutritional ketosis. These diets have been proposed to benefit patients with MASLD by promoting weight loss, reducing inflammation and insulin resistance through different pathways. This review summarized the current findings on the outcomes of ketogenic diets on patients with MASLD regarding the liver, plasma lipid profile, systemic inflammation and gut microbiota. Studies showed that short- to medium- term ketogenic diets, with or without calorie restriction, are able to lower plasma triglycerides and ameliorate hepatic steatosis, steatohepatitis and fibrosis in MASLD. In particular, studies found ketogenic diets may be more effective in alleviating hepatic steatosis in short time periods than calorie-matched, high-carbohydrate, low-fat diets. Evidence on the impact on plasma high-density lipoprotein cholesterol (HDL-c) and low-density lipoprotein cholesterol (LDL-c) was mixed. Clinical trials investigating the effects on different markers of systemic inflammation and the composition of gut microbiota among patients with MASLD were scarce. To better understand the role of ketogenic diets in MASLD management, longer-term, well-controlled trials are warranted to clarify their potential benefits and risks, and whether they are varied by types of fats. Appropriate and sustainable formulations of ketogenic diets that maximize benefits and minimize side effects remain to be determined. C1 [Sun, Kexin; Nelson, Edmund Anthony Severn] Chinese Univ Hong Kong, Sch Med, Shenzhen 518172, Guangdong, Peoples R China. [Li, Weitian] Chinese Univ Hong Kong, Dept Pediat, Sha Tin Dist, Hong Kong, Peoples R China. [Chen, Yunan] Hong Kong Polytech Univ, Sch Hotel & Tourism Management, Hung Hom, Hong Kong, Peoples R China. [Nelson, Edmund Anthony Severn] Hong Kong Polytech Univ, Dept Food Sci & Nutr, Hung Hom, Hong Kong, Peoples R China. [Chen, Xu; Hui, Lai Ling] Hong Kong Polytech Univ, Dept Food Sci & Nutr, Hung Hom, 3-F Core T, Hong Kong, Peoples R China. C3 The Chinese University of Hong Kong, Shenzhen; Chinese University of Hong Kong; Hong Kong Polytechnic University; Hong Kong Polytechnic University; Hong Kong Polytechnic University RP Nelson, EAS (通讯作者)，Chinese Univ Hong Kong, Sch Med, Shenzhen 518172, Guangdong, Peoples R China.; Nelson, EAS (通讯作者)，Hong Kong Polytech Univ, Dept Food Sci & Nutr, Hung Hom, Hong Kong, Peoples R China.; Chen, X; Hui, LL (通讯作者)，Hong Kong Polytech Univ, Dept Food Sci & Nutr, Hung Hom, 3-F Core T, Hong Kong, Peoples R China. 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PD DEC 15 PY 2025 VL 16 IS 1 AR 5 DI 10.1186/s13578-025-01494-8 PG 12 WC Biochemistry & Molecular Biology WE Science Citation Index Expanded (SCI-EXPANDED) SC Biochemistry & Molecular Biology GA CH8NF UT WOS:001666142500001 PM 41392263 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Alfieri, CM Molinari, P Cinque, F Vettoretti, S Cespiati, A Bignamini, D Nardelli, L Fracanzani, AL Castellano, G Lombardi, R AF Alfieri, Carlo Maria Molinari, Paolo Cinque, Felice Vettoretti, Simone Cespiati, Annalisa Bignamini, Daniela Nardelli, Luca Fracanzani, Anna Ludovica Castellano, Giuseppe Lombardi, Rosa TI What Not to Overlook in the Management of Patients with Type 2 Diabetes Mellitus: The Nephrological and Hepatological Perspectives SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES LA English DT Review DE chronic kidney disease; diabetic kidney disease; metabolic dysfunction-associated steatotic liver disease; liver fibrosis; hyperfiltration ID FATTY LIVER-DISEASE; CHRONIC KIDNEY-DISEASE; CONTROLLED-TRIAL; WEIGHT-LOSS; EPIDEMIOLOGY; SUSCEPTIBILITY; PREVALENCE; FEATURES; UPDATE; NAFLD AB Diabetes mellitus (DM) significantly impacts renal and hepatic function, necessitating comprehensive understanding and management strategies. Renal involvement, namely diabetic kidney disease (DKD), presents a global challenge, with increasing prevalence paralleling DM rates. Lifestyle modifications and pharmacotherapy targeting hypertension and glycemic control have pivotal roles in DKD management. Concurrently, hepatic involvement in DM, characterized by metabolic dysfunction-associated steatotic liver disease (MASLD), presents a bidirectional relationship. DM exacerbates MASLD progression, while MASLD predisposes to DM development and worsens glycemic control. Screening for MASLD in DM patients is of high importance, utilizing non-invasive methods like ultrasound and fibrosis scores. Lifestyle modifications, such as weight loss and a Mediterranean diet, mitigate MASLD progression. Promising pharmacotherapies, like SGLT2 inhibitors and GLP-1 agonists, demonstrate efficacy in both DM and MASLD management. Special populations, such as diabetic individuals undergoing hemodialysis or kidney transplant recipients, demand special care due to unique clinical features. Similarly, DM exacerbates complications in MASLD patients, elevating the risks of hepatic decompensation and hepatocellular carcinoma. Recognizing the interconnectedness of DM, renal, and hepatic diseases underscores the need for multidisciplinary approaches for optimal patient outcomes. The present review aims to present the main characteristics and crucial points not to be overlooked regarding the renal and hepatic involvement in DM patients focusing on the inter-relationships between the renal and the hepatic involvements. C1 [Alfieri, Carlo Maria; Molinari, Paolo; Vettoretti, Simone; Nardelli, Luca; Castellano, Giuseppe] Fdn IRCCS CaGranda Osped Policlin, Dept Nephrol Dial & Renal Transplantat, I-20122 Milan, Italy. [Alfieri, Carlo Maria; Nardelli, Luca; Castellano, Giuseppe] Univ Milan, Dept Clin Sci & Community Hlth, I-20122 Milan, Italy. [Molinari, Paolo] Univ Milan, Postgrad Sch Specializat Nephrol, I-20122 Milan, Italy. [Cinque, Felice; Cespiati, Annalisa; Bignamini, Daniela; Fracanzani, Anna Ludovica; Lombardi, Rosa] Fdn IRCCS CaGranda Osped Maggiore Policlin Milano, SC Med Indirizzo Metab, I-20122 Milan, Italy. [Cinque, Felice; Cespiati, Annalisa; Fracanzani, Anna Ludovica; Lombardi, Rosa] Univ Milan, Dept Pathophysiol & Transplantat, I-20122 Milan, Italy. C3 University of Milan; University of Milan; University of Milan RP Cinque, F (通讯作者)，Fdn IRCCS CaGranda Osped Maggiore Policlin Milano, SC Med Indirizzo Metab, I-20122 Milan, Italy.; Cinque, F (通讯作者)，Univ Milan, Dept Pathophysiol & Transplantat, I-20122 Milan, Italy. EM carlo.alfieri1@gmail.com; felice.cinque@unimi.it; annalisa.cespiati@unimi.it; daniela.bignamini@policlinico.mi.it; luca.nardelli@unimi.it; anna.fracanzani@unimi.it; giuseppe.castellano@unimi.it; rosa.lombardi@unimi.it RI vettoretti, simone/L-1083-2016; Alfieri, Carlo/Q-8959-2016; Lombardi, Rosa/AAB-8031-2019; Cespiati, Annalisa/GRJ-1523-2022; Fracanzani, Anna Ludovica/J-8986-2018; castellano, giuseppe/H-1626-2012; CINQUE, FELICE/LTE-1682-2024 OI vettoretti, simone/0000-0002-1040-4952; Alfieri, Carlo/0000-0003-3860-5219; molinari, paolo/0000-0001-6196-5656; Lombardi, Rosa/0000-0001-6958-927X; Fracanzani, Anna Ludovica/0000-0001-5918-0171; CINQUE, FELICE/0000-0003-1499-9233 FU University of Milan through the APC initiative FX The authors acknowledge the support of the University of Milan through the APC initiative. 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J. Mol. Sci. PD JUL PY 2024 VL 25 IS 14 AR 7728 DI 10.3390/ijms25147728 PG 23 WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary WE Science Citation Index Expanded (SCI-EXPANDED) SC Biochemistry & Molecular Biology; Chemistry GA ZT3O7 UT WOS:001277504700001 PM 39062970 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Doustmohammadian, A Zamani, F Hébert, JR Moradi-Lakeh, M Esfandyiari, S Amirkalali, B Motamed, N Maadi, M Price, S Gholizadeh, E Ajdarkosh, H AF Doustmohammadian, Azam Zamani, Farhad Hebert, James R. Moradi-Lakeh, Maziar Esfandyiari, Sepideh Amirkalali, Bahareh Motamed, Nima Maadi, Mansooreh Price, Sherry Gholizadeh, Esmaeel Ajdarkosh, Hossein TI Exploring the link between dietary inflammatory index and NAFLD through a structural equation modeling approach SO JOURNAL OF HEALTH POPULATION AND NUTRITION LA English DT Article DE Diet; Dietary inflammatory index; NAFLD; Structural equation modeling; Iranian cohort ID FATTY LIVER-DISEASE; C-REACTIVE PROTEIN; MEDITERRANEAN DIET; METABOLIC SYNDROME; PHYSICAL-ACTIVITY; BLOOD-PRESSURE; PREVALENCE; ASSOCIATION; ATHEROSCLEROSIS; NUTRITION AB Nonalcoholic fatty liver disease (NAFLD) or metabolic dysfunction-associated steatotic liver disease (MASLD) is a significant global public health dilemma with wide-ranging social and economic implications. Diet and lifestyle modifications remain essential components of NAFLD management. The current study investigated the association between diet-related inflammation and NAFLD among 3110 Iranian adults participating in the Amol Cohort Study (AmolCS), employing the Structural Equation Modeling (SEM) approach.The inflammatory potential of the diet was quantified using an energy-adjusted dietary index (E-DII) score. Findings showed that in the total sample and separately in males, the E-DII score had a significant effect on NAFLD, with mediation through hypertension (beta(standardized) = 0.16, and 0.13, p < 0.001, respectively) and c-reactive protein (CRP) (beta(standardized) = 0.07, and 0.07, p < 0.001, respectively). In the total sample and separately in females, the E-DII score significantly affected NAFLD, with mediation through diabetes (beta(standardized) = 0.06, p < 0.001, and 0.07, p = 0.006, respectively). In full and both gender-specific models, dyslipidemia was a risk factor for NAFLD and partially mediated the effect of hypertension on NAFLD. The current study concluded a mediated association between dietary inflammation and NAFLD through hypertension, CRP, diabetes, and dyslipidemia, suggesting further longitudinal studies, especially in high-risk populations. These findings underscore the complex interplay between diet, inflammation, and NAFLD in Iranian adults. C1 [Doustmohammadian, Azam; Zamani, Farhad; Amirkalali, Bahareh; Maadi, Mansooreh; Gholizadeh, Esmaeel; Ajdarkosh, Hossein] Iran Univ Med Sci, Gastrointestinal & Liver Dis Res Ctr, Tehran, Iran. [Hebert, James R.; Price, Sherry] Univ South Carolina, Canc Prevent & Control Program, Columbia, SC 29208 USA. [Hebert, James R.; Price, Sherry] Univ South Carolina, Dept Epidemiol & Biostat, Columbia, SC 29208 USA. [Moradi-Lakeh, Maziar] Univ Med Sci, Psychosocial Hlth Res Inst, Prevent Med & Publ Hlth Res Ctr, Tehran, Iran. [Esfandyiari, Sepideh] Univ Tehran Med Sci, Sch Publ Hlth, Dept Epidemiol & Biostat, Tehran, Iran. [Motamed, Nima] Zanjan Univ Med Sci, Dept Social Med, Zanjan, Iran. C3 Iran University of Medical Sciences; University of South Carolina System; University of South Carolina Columbia; University of South Carolina System; University of South Carolina Columbia; Tehran University of Medical Sciences; Tehran University of Medical Sciences RP Ajdarkosh, H (通讯作者)，Iran Univ Med Sci, Gastrointestinal & Liver Dis Res Ctr, Tehran, Iran. EM doost_mohammadi@yahoo.com; zamani.f@iums.ac.ir; jhebert@mailbox.sc.edu; moradilakeh.m@iums.ac.ir; s.esfandiyari.93@gmail.com; kalalinutms@yahoo.com; nima.motamed@gmail.com; maadi_mansooreh@yahoo.com; sprice@chi-llc.net; gholizadeh.esmaeel@gmail.com; ajdarkosh.h@iums.ac.ir RI Moradi-Lakeh, Maziar/ABC-9793-2021; Doustmohammadian, Azam/HNQ-0687-2023; Hebert, James/IUO-5628-2023; Zamani, Farhad/ABH-8503-2020; Motamed, Nima/N-6095-2016; Gholizadeh, Esmaeel/HKP-0088-2023 OI Moradi-Lakeh, Maziar/0000-0001-7381-5305; Amirkalali, Bahareh/0000-0001-6068-4019; Hebert, James/0000-0002-0677-2672; Price, Sherry/0009-0006-3547-0493 FU Iran University of Medical Sciences; GILDRC team [1401-3-75-22501]; Iran University of Medical Sciences (IUMS) FX We wish to convey our gratitude to the participants, the healthcare leaders, and the GILDRC team (//www.gildrc.ac.ir), for their valuable contribution to this study. Additionally, we express our gratitude to the Iran University of Medical Sciences (IUMS) for providing funding for this research (grant NO: 1401-3-75-22501). 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PD DEC 24 PY 2024 VL 43 IS 1 AR 224 DI 10.1186/s41043-024-00721-1 PG 10 WC Environmental Sciences; Public, Environmental & Occupational Health WE Science Citation Index Expanded (SCI-EXPANDED) SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA Q2I8I UT WOS:001382993000001 PM 39719637 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Yang, WT Jin, Q Xiao, DW Li, X Huang, DF AF Yang, Wentai Jin, Qing Xiao, Dewang Li, Xiang Huang, Defa TI Interaction mechanism and intervention strategy between metabolic dysfunction-associated steatotic liver disease and intestinal microbiota SO FRONTIERS IN MICROBIOLOGY LA English DT Review DE metabolic dysfunction-associated steatotic liver disease; gut microbiota; gut-liver axis; microbial metabolites; probiotics; prebiotics; fecal microbiota transplantation ID FATTY LIVER; GUT MICROBIOTA; TRANSPLANTATION; FIBROSIS; NAFLD AB The interaction between metabolic dysfunction-associated seatotic liver disease (MASLD) and gut microbiota regulates hepatic metabolic homeostasis through the gut-liver axis, and its mechanisms involve intestinal dysbiosis (decreased bacteroidetes, increased ratio of firmicutes/proteobacteria), bile acid metabolism reprogramming (secondary bile acids inhibit FXR signaling), short-chain fatty acid (SCFAs) deficiency, and endotoxin-mediated inflammatory activation (TLR4/NF-kappa B pathway). Among the intervention strategies, probiotics (such as Bifidobacteria) improved inflammation by regulating microbiota structure and intestinal barrier function, prebiotics such as resistant starch enriched butyric acid-producing bacteria and reduced liver lipid deposition, fecal microbiota transplantation (FMT) could remodel the microbiota but needed to optimize safety, restricted fructose intake and Mediterranean diet reduced liver damage by regulating microbiota metabolism, and metabolic surgery improved fibrosis through microbiota remodeling and bile acid signaling. In the future, it is necessary to combine multi-omics technology to analyze the microbiota-host interaction network, develop precision therapies such as phage targeted clearance or engineering bacterial delivery of metabolites, and promote the clinical transformation of personalized intervention programs. C1 [Yang, Wentai] Gannan Med Univ, Affiliated Hosp 1, Dept Gastroenterol, Ganzhou, Peoples R China. [Yang, Wentai; Jin, Qing; Xiao, Dewang; Li, Xiang; Huang, Defa] Gannan Med Univ, Clin Med Coll 1, Ganzhou, Peoples R China. [Jin, Qing; Huang, Defa] Gannan Med Univ, Affiliated Hosp 1, Lab Med, Ganzhou, Peoples R China. C3 Gannan Medical University; Gannan Medical University; Gannan Medical University RP Yang, WT (通讯作者)，Gannan Med Univ, Affiliated Hosp 1, Dept Gastroenterol, Ganzhou, Peoples R China.; Yang, WT; Huang, DF (通讯作者)，Gannan Med Univ, Clin Med Coll 1, Ganzhou, Peoples R China.; Huang, DF (通讯作者)，Gannan Med Univ, Affiliated Hosp 1, Lab Med, Ganzhou, Peoples R China. 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Microbiol. PD SEP 18 PY 2025 VL 16 AR 1597995 DI 10.3389/fmicb.2025.1597995 PG 10 WC Microbiology WE Science Citation Index Expanded (SCI-EXPANDED) SC Microbiology GA 8CG8J UT WOS:001585242700001 PM 41048505 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Jurek, JM Zablocka-Sowinska, K Mestres, HC Gutiérrez, LR Camaron, J Auguet, T AF Jurek, Joanna Michalina Zablocka-Sowinska, Katarzyna Mestres, Helena Clavero Gutierrez, Leyre Reyes Camaron, Javier Auguet, Teresa TI The Impact of Dietary Interventions on Metabolic Outcomes in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) and Comorbid Conditions, Including Obesity and Type 2 Diabetes SO NUTRIENTS LA English DT Review DE dietary intervention; metabolic outcomes; obesity; MASLD/non-alcoholic fatty liver disease; type 2 diabetes; metabolic syndrome; Mediterranean; systematic review ID FATTY LIVER; MEDITERRANEAN DIET; DASH DIET; ADHERENCE; WEIGHT; ADULTS; RISK AB Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a public health concern, linked with immune-metabolic dysfunction. While lifestyle and dietary modifications remain the cornerstone of MASLD management, the optimal dietary approach remains uncertain. Objectives: This systematic review aims to investigate the impact of model dietary patterns on metabolic outcomes in patients with MASLD and evaluate their effects in individuals with coexisting metabolic conditions, such as obesity, metabolic syndrome, and type 2 diabetes mellitus (T2DM). Methods: To conduct the review, PubMed, Scopus, Google Scholar, Cochrane CENTRAL, and ClinicalTrials.gov databases were searched for Randomized Controlled Trials (RCTs) on the adult population, published between January 2019 and September 2024, following PRISMA principles. The quality of the included RCTs was assessed qualitatively based on study characteristics. Results: The main findings of this review demonstrated that the use of interventions with dietary model based on Mediterranean diet (MED) and intermittent fasting (IF) approaches, such as alternative-day fasting (ADF) and time-restricted feeding regimens (TRF) may have potential in reducing body weight, BMI, and waist circumference, with additional benefits of improving glycemic control and reducing inflammation. The effects on hepatic functions, although limited, may be linked with reduced enzyme activity and liver stiffness. Additionally, the use of lacto-ovo-vegetarian diet (LOV-D) and the Dietary Approaches to Stop Hypertension (DASH) diet may offer additional health benefits, including blood pressure management. Conclusions: This review suggests that MED and IF-based strategies may reduce BW, improve glycemic control, and lower inflammation, with potential benefits for hepatic function. Further long-term studies are needed to confirm these effects and underlying mechanisms, which will allow for the optimization of protocols and ensure their safety in MASLD. C1 [Jurek, Joanna Michalina; Mestres, Helena Clavero; Gutierrez, Leyre Reyes; Auguet, Teresa] Univ Rovira i Virgili URV, Inst Invest Sanitaria Pere Virgili IISPV, Dept Med & Cirurg, Grp Recerca GEMMAIR AGAUR Med Aplicada URV, Mallafre Guasch 4, Tarragona 43007, Spain. [Zablocka-Sowinska, Katarzyna] WSB Merito Univ Wroclaw, Fac Finance & Management, PL-53609 Wroclaw, Poland. [Camaron, Javier; Auguet, Teresa] Hosp Univ Tarragona Joan XXIII, Serv Med Interna, Mallafre Guasch 4, Tarragona 43007, Spain. C3 Universitat Rovira i Virgili; Institut d'Investigacio Sanitaria Pere Virgili (IISPV); Universitat Rovira i Virgili; Hospital Universitari De Tarragona Joan XXIII RP Auguet, T (通讯作者)，Univ Rovira i Virgili URV, Inst Invest Sanitaria Pere Virgili IISPV, Dept Med & Cirurg, Grp Recerca GEMMAIR AGAUR Med Aplicada URV, Mallafre Guasch 4, Tarragona 43007, Spain.; Auguet, T (通讯作者)，Hosp Univ Tarragona Joan XXIII, Serv Med Interna, Mallafre Guasch 4, Tarragona 43007, Spain. EM joannamichalina.jurek@urv.cat; katarzyna.zablocka-slowinska@wroclaw.merito.pl; helena.clavero@urv.cat; leyre.reyes@estudiants.urv.cat; jcamaronm.hj23.ics@gencat.cat; tauguet.hj23.ics@gencat.cat RI Auguet, Teresa/AAC-5838-2020 OI Auguet, Teresa/0000-0003-0396-6428; Jurek, Joanna Michalina/0000-0002-7319-0672; Reyes-Gutiérrez, Leyre/0009-0005-5047-5543; Clavero Mestres, Helena/0009-0004-0001-1866 FU Agencia de Gestio d'Ajuts Universitaris de Recerca [AGAUR-2021-SGR-00030]; INVESTIGO Program URV, AGAUR and Plan de Recuperacion, Transformacion y Resiliencia [2023POST-INV-10] FX This study has supported by funds from Agencia de Gestio d'Ajuts Universitaris de Recerca (AGAUR-2021-SGR-00030 to Teresa Auguet), and by the INVESTIGO Program from the URV, AGAUR and Plan de Recuperacion, Transformacion y Resiliencia (2023POST-INV-10 to Teresa Auguet). 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Ivey, Kerry L. Chang, Kyong-Mi Kaplan, David E. TI Diet composition impacts the natural history of steatotic liver disease SO HEPATOLOGY COMMUNICATIONS LA English DT Article DE betaine; caffeine; cirrhosis; coffee; decompensation; diet; fatty liver; fibrosis; fibrosis-4; FIB-4; fructose; Mediterranean diet; metabolic-associated steatohepatitis; metabolic-associated steatotic liver disease ID NONALCOHOLIC FATTY LIVER; INSULIN-RESISTANCE; CONSUMPTION; MANAGEMENT AB Background:Metabolic-associated steatotic liver disease (MASLD), caused by insulin resistance and the metabolic syndrome, may result in progressive liver fibrosis. Animal studies suggest that dietary content modulates liver fibrosis progression. Our aim was to identify dietary components and food-related behaviors that may be associated with fibrosis progression and liver-related outcomes in a well-characterized human MASLD cohort.Methods:Patients with MASLD who had completed a detailed Lifestyle Survey, including a semiquantitative Food Frequency Questionnaire in the Veterans Health Administration Million Veteran Program, were included. The primary outcome was liver fibrosis progression using the Fibrosis-4 slope; the secondary outcome was time to cirrhosis by ICD9/10 codes. Key baseline covariates included: race/ethnicity, body mass index, diabetes mellitus, AUDIT-C score, and baseline Fibrosis-4 score. Using bootstrapped Elastic Net regression in R, self-reported food intake and scaled nutrient variables of interest associated with the outcomes were identified and then validated using multivariable Generalized Linear Model and Cox models.Results:A total of 84,024 individuals with MASLD with nutritional data were included in this study. Median age at MASLD diagnosis was 56 years (IQR 49-63). Frequency of consumption of coffee, tea, vegetables (broccoli, spinach/collard greens), legumes, nuts, modest alcohol, white meat, rice/pasta, dairy, and intakes of specific nutrients including nitrate/vitamin K, caffeine, betaine, amino acids, and beta carotene were associated with reduced fibrosis progression. Consumption of white bread, cookies, breakfast cereals, and specific nutrients such as iron (non-heme), B vitamins, and flavanones were all significantly associated with increased fibrosis progression in MASLD (p<0.05).Conclusions:Dietary choices such as intake of processed foods, high-fructose foods, and refined carbohydrates may be associated with MASLD progression, while intake of vegetables, nuts, whole grains, and caffeine may be protective. C1 [Callans, Lauren E.; Chang, Kyong-Mi; Kaplan, David E.] Corporal Michael J Crescenz VA Med Ctr, Dept Gastroenterol Sect, Philadelphia, PA USA. [Callans, Lauren E.; Chang, Kyong-Mi; Kaplan, David E.] Univ Penn, Perelman Sch Med, Dept Med, Philadelphia, PA USA. [Ivey, Kerry L.] Boston Vet Affairs Healthcare Syst, Massachusetts Vet Epidemiol & Res Informat Ctr MAV, Boston, MA USA. [Ivey, Kerry L.] Brigham & Womens Hosp, Dept Med, Div Aging, Boston, MA USA. [Ivey, Kerry L.] Harvard Med Sch, Dept Med, Boston, MA USA. C3 University of Pennsylvania; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard University; Harvard Medical School RP Kaplan, DE (通讯作者)，CMCVAMC, 3900 Woodland Ave,Bldg 21, Philadelphia, PA 19104 USA. EM bqi9003@nyp.org; klivey@bwh.harvard.edu; kmchang@pennmedicine.upenn.edu; dakaplan@pennmedicine.upenn.eduon OI Kaplan, David/0000-0002-3839-336X; Chang, Kyong-Mi/0000-0001-6811-9364; Ivey, Kerry/0000-0001-9855-2599 FU Veterans Administration [I01-CX002010, I01-CX002337, I01-CX002542]; [MVP000]; [I01-BX003362]; [MVP003/028] FX This research is based on data from the Million Veteran Program (MVP), Office of Research and Development, Veterans Health Administration and was supported by MVP000 as well as award #I01-BX003362 entitled MVP003/028: Genetics of Cardiometabolic Diseases in the VA Population (Kyong-Mi Chang). David E. Kaplan is supported by the Veterans Administration [I01-CX002010, I01-CX002337, I01-CX002542]. This publication does not represent the views of the Department of Veterans Affairs, the U.S. Food and Drug Administration, or the U.S.Government. We thank all MVP participants and research team members for their contributions. The content is the responsibility of the authors alone and does not necessarily reflect the views of or imply endorsement by the U.S. Government. CR Ackerman Z, 2005, HYPERTENSION, V45, P1012, DOI 10.1161/01.HYP.0000164570.20420.67 American Heart Association, 2024, What is the Mediterranean Diet? 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Commun. PD JUL PY 2025 VL 9 IS 7 AR e0754 DI 10.1097/HC9.0000000000000754 PG 17 WC Gastroenterology & Hepatology WE Science Citation Index Expanded (SCI-EXPANDED) SC Gastroenterology & Hepatology GA 3XT6U UT WOS:001511537900001 PM 40536509 OA gold DA 2026-02-02 ER PT J AU Rupasinghe, K Hind, J Hegarty, R AF Rupasinghe, Kushila Hind, Jonathan Hegarty, Robert TI Updates in Metabolic Dysfunction-Associated Fatty Liver Disease (MAFLD) in Children SO JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION LA English DT Review DE children; fatty liver disease; metabolic dysfunction-associated fatty liver disease (MAFLD); non-alcoholic fatty liver disease (NAFLD); paediatric; pediatric ID LIFE-STYLE INTERVENTION; NONALCOHOLIC STEATOHEPATITIS; HEPATIC STEATOSIS; OBESE CHILDREN; MEDITERRANEAN DIET; ADOLESCENTS; FIBROSIS; NAFLD; PREVALENCE; DIAGNOSIS AB The obesity epidemic is one of the major health concerns of the 21st century. Nonalcoholic fatty liver disease (NAFLD) is linked with the increased adiposity associated with obesity. NAFLD has become the most frequent cause of chronic liver disease in adults and children worldwide. Metabolic dysfunction-associated fatty liver disease (MAFLD) also known in children as pediatric fatty liver disease (PeFLD) type 2 has begun to supersede NAFLD as the preferred nomenclature in the pediatric population. Evidence suggests the etiology of MAFLD is multifactorial, related to the complex interplay of hormonal, nutritional, genetic, and environmental factors. Current limitations in accurate diagnostic biomarkers have rendered it a diagnosis of exclusion and it is important to exclude alternative or coexisting causes of PeFLD. Lifestyle changes and modifications remains the primary treatment modality in MAFLD in children. Weight loss of 7%-10% is described as reversing MAFLD in most patients. The Mediterranean diet also shows promise in reversing MAFLD. Pharmacological intervention is debatable in children, and though pediatric trials have not shown promise, other agents undergoing adult clinical trials show promise. This review outlines the latest evidence in pediatric MAFLD and its management. C1 [Rupasinghe, Kushila; Hind, Jonathan; Hegarty, Robert] Kings Coll Hosp London, Paediat Liver GI & Nutr Ctr, London, England. [Rupasinghe, Kushila] Kings Coll Hosp London, Paediat Liver GI & Nutr Ctr, London SE5 9RS, England. C3 King's College Hospital NHS Foundation Trust; King's College Hospital; King's College Hospital NHS Foundation Trust; King's College Hospital RP Rupasinghe, K (通讯作者)，Kings Coll Hosp London, Paediat Liver GI & Nutr Ctr, London SE5 9RS, England. 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Pediatr. Gastroenterol. Nutr. PD NOV PY 2023 VL 77 IS 5 BP 583 EP 591 DI 10.1097/MPG.0000000000003919 PG 9 WC Gastroenterology & Hepatology; Nutrition & Dietetics; Pediatrics WE Science Citation Index Expanded (SCI-EXPANDED) SC Gastroenterology & Hepatology; Nutrition & Dietetics; Pediatrics GA W5KG0 UT WOS:001092007500012 PM 37592398 DA 2026-02-02 ER PT J AU Us, GD Innocenti, F Koc, OM Alagoz, AE Yumuk, VD Gungor, ZB Koek, GH AF Dogay Us, Gediz Innocenti, Francesco Koc, Ozgur Muhammet Alagoz, Ayse Eylul Yumuk, Volkan Demirhan Gungor, Zeynep Banu Koek, Ger H. TI Mediterranean and low-fat diets are equally effective in MASLD resolution at 12 weeks regardless of PNPLA3 genotype: A randomized controlled trial SO HEPATOLOGY COMMUNICATIONS LA English DT Article DE fatty liver; low-fat diet; MASLD; Mediterranean diet; NAFLD; PNPLA3 ID LIFE-STYLE MODIFICATION; WEIGHT-LOSS; HEPATIC STEATOSIS; PHYSICAL-ACTIVITY; LIVER FAT; CARBOHYDRATE; QUESTIONNAIRE; ADHERENCE; SEVERITY; DISEASE AB Background:Dietary interventions are key for managing metabolic dysfunction-associated steatotic liver disease (MASLD), yet optimal diets and the role of PNPLA3 in modulating response to diet remain unclear. We evaluated the efficacy of a Mediterranean diet (MD) versus a low-fat diet (LFD) on hepatic fat and fibrosis, assessing interactions with PNPLA3 genotype.Methods:Two hundred fifty adults with MASLD with BMI >= 25 kg/m2 were randomized to a 12-week moderately hypocaloric MD or LFD intervention. Individuals with excess alcohol intake and other etiologies of steatosis were excluded. Subjects were genotyped for PNLPA3 single-nucleotide polymorphism. Anthropometric measures, blood tests, and liver assessments [controlled attenuation parameter (CAP) and liver stiffness measurement (LSM)] were conducted at baseline and follow-up. Essential food items were provided, and adherence was tracked using validated questionnaires. The primary outcome was CAP, analyzed using linear mixed models adjusted for age and metabolic syndrome.Results:Both diets significantly reduced CAP, LSM, and body weight at follow-up, with no significant differences between groups. The mean difference between MD and LFD was -0.13 dB/m for CAP (p=0.976, 95% CI: -8.54, 8.28), -0.19 kPa for LSM (p=0.355, 95% CI: -0.58, 0.21), and 3.01 kg for weight (p=0.159, 95% CI: -7.21, 1.19). PNPLA3 genotype did not significantly interact with diet for CAP, LSM, or weight (p=0.286, p=0.464, p=0.622, respectively).Conclusions:Weight reduction achieved by MD and LFD is similarly efficient in steatosis and fibrosis reduction, while PNPLA3 genotype does not affect the response to diet. Further studies investigating the impact of diet and nutrigenetics on liver-related outcomes are warranted. C1 [Dogay Us, Gediz; Koek, Ger H.] Maastricht Univ, Sch Nutr & Translat Res Metab, Maastricht, Netherlands. [Dogay Us, Gediz] Pax Clin, Dept Gastroenterol, Istanbul, Turkiye. [Dogay Us, Gediz; Yumuk, Volkan Demirhan] Istanbul Univ Cerrahpasa, Cerrahpasa Med Fac, Div Endocrinol Metab & Diabet, Istanbul, Turkiye. [Innocenti, Francesco] Maastricht Univ, CAPHRI Care & Publ Hlth Res Inst, Dept Methodol & Stat, Maastricht, Netherlands. [Koc, Ozgur Muhammet; Koek, Ger H.] Maastricht Univ, Med Ctr, Dept Gastroenterol Hepatol, Maastricht, Netherlands. [Alagoz, Ayse Eylul; Gungor, Zeynep Banu] Istanbul Univ Cerrahpasa, Cerrahpasa Med Fac, Dept Med Biochem, Istanbul, Turkiye. C3 Maastricht University; Istanbul University - Cerrahpasa; Maastricht University; Maastricht University; Istanbul University - Cerrahpasa RP Us, GD (通讯作者)，Maastricht Univ, Med Ctr, POB 5800, NL-6202 AZ Maastricht, Netherlands. EM g.dogay@maastrichtuniversity.nl; francesco.innocenti@maastrichtuniversity.nl; o.koc@mumc.nl; ayseeylulalagoz@gmail.com; vdyumuk@istanbul.edu.tr; zeynepbanu.gungor@iuc.edu.tr; gh.koek@mumc.nl RI Yumuk, Volkan/AAB-6871-2021; Gungor, Zeynep/D-3779-2019; Innocenti, Francesco/AAI-7979-2020; Dogay Us, Gediz/OYE-3246-2025 OI Gungor, Zeynep/0000-0002-0649-844X; Innocenti, Francesco/0000-0001-6113-8992; Dogay Us, Gediz/0000-0003-0313-8673 FU Health Institutes of Turkey (TUSEB) FX This study was funded by the Health Institutes of Turkey (TUSEB). The sponsor played no role in the collection, analysis, or interpretation of data. 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Commun. PD DEC PY 2025 VL 9 IS 12 AR e0856 DI 10.1097/HC9.0000000000000856 PG 13 WC Gastroenterology & Hepatology WE Science Citation Index Expanded (SCI-EXPANDED) SC Gastroenterology & Hepatology GA D0740 UT WOS:001621167500001 PM 41284948 OA gold DA 2026-02-02 ER PT J AU Tobaruela-Resola, AL Riezu-Boj, JI Milagro, FI Mogna-Pelaez, P Herrero, JI Elorz, M Benito-Boillos, A Tur, JA Martínez, JA Abete, I Zulet, MA AF Tobaruela-Resola, Ana Luz Riezu-Boj, Jose Ignacio Milagro, Fermin I. Mogna-Pelaez, Paola Herrero, Jose I. Elorz, Mariana Benito-Boillos, Alberto Tur, Josep A. Martinez, J. Alfredo Abete, Itziar Zulet, Maria Angeles TI Circulating microRNA panels in subjects with metabolic dysfunction-associated steatotic liver disease after following a 2-year dietary intervention SO JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION LA English DT Article DE MASLD; NAFLD; MiRNA; Biomarker; Nutritional intervention; Fatty liver ID MEDITERRANEAN DIET; POPULATION; BIOMARKERS; SIGNATURE AB PurposeMetabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) affects one-third of the global population. Despite its high prevalence, there is a lack of minimally non-invasive diagnostic methods to assess this condition. This study explores the potential of circulating microRNAs (miRNAs) as diagnostic biomarkers for MASLD after a 2-year nutritional intervention.MethodsFifty-five subjects with steatosis (MASLD group) from the Fatty Liver in Obesity (FLiO) study (NCT03183193) were analyzed at baseline and after 6, 12 and 24 months. Participants were classified into two groups: those who still had steatosis after the intervention (unhealthy group) and those in whom steatosis had disappeared (healthy group). Hepatic status was evaluated through magnetic resonance imaging (MRI), ultrasonography, elastography and serum transaminases. Circulating miRNA levels were measured by RT-PCR.ResultsThe dietary intervention was able to modulate the expression of circulating miRNAs after 6, 12, and 24 months. Logistic regression analyses revealed that the most effective panels for diagnosing whether MASLD has disappeared after the nutritional intervention included miR15b-3p, miR126-5p and BMI (AUC 0.68) at 6 months, miR29b-3p, miR122-5p, miR151a-3p and BMI (AUC 0.85) at 12 months and miR21-5p, miR151a-3p and BMI at 24 months (AUC 0.85).ConclusionsCirculating miRNAs were useful in predicting MASLD in subjects with overweight or obesity after following a weight-loss oriented nutritional intervention. These findings highlight the potential role of miRNAs in diagnosing MASLD and underscore the importance of precision nutrition in managing and determining MASLD.Clinical trial registrationTrial registration number: NCT03183193 (www.clinicaltrials.gov). C1 [Tobaruela-Resola, Ana Luz; Riezu-Boj, Jose Ignacio; Milagro, Fermin I.; Mogna-Pelaez, Paola; Abete, Itziar; Zulet, Maria Angeles] Univ Navarra, Fac Pharm & Nutr, Ctr Nutr Res, Dept Nutr Food Sci & Physiol, Pamplona 31008, Spain. [Riezu-Boj, Jose Ignacio; Milagro, Fermin I.; Herrero, Jose I.; Elorz, Mariana; Benito-Boillos, Alberto; Abete, Itziar; Zulet, Maria Angeles] Navarra Inst Hlth Res IdiSNA, Pamplona 31008, Spain. [Milagro, Fermin I.; Tur, Josep A.; Martinez, J. Alfredo; Abete, Itziar; Zulet, Maria Angeles] Inst Salud Carlos III, Ctr Invest Biomed Red Fisiopatol Obes & Nutr CIBER, Madrid 28029, Spain. [Herrero, Jose I.] Clin Univ Navarra, Liver Unit, Pamplona 31008, Spain. [Herrero, Jose I.] Biomed Res Ctr Network Hepat & Digest Dis CIBERehd, Madrid 28029, Spain. [Elorz, Mariana; Benito-Boillos, Alberto] Clin Univ Navarra, Dept Radiol, Pamplona 31008, Spain. [Tur, Josep A.] Univ Balear Isl, Res Grp Community Nutr & Oxidat Stress, IUNICS, Palma De Mallorca 07122, Spain. [Tur, Josep A.] IDISBA, Palma De Mallorca 07122, Spain. [Martinez, J. Alfredo] CSIC, Precis Nutr & Cardiovasc Hlth Program, IMDEA Food, CEI,UAM, Madrid 28049, Spain. C3 University of Navarra; University of Navarra; Instituto de Salud Carlos III; University of Navarra; University of Navarra; Universitat de les Illes Balears; IUNICS; Institut Investigacio Sanitaria Illes Balears (IdISBa); Consejo Superior de Investigaciones Cientificas (CSIC); Autonomous University of Madrid; IMDEA Food Institute RP Zulet, MA (通讯作者)，Univ Navarra, Fac Pharm & Nutr, Ctr Nutr Res, Dept Nutr Food Sci & Physiol, Pamplona 31008, Spain.; Zulet, MA (通讯作者)，Navarra Inst Hlth Res IdiSNA, Pamplona 31008, Spain.; Zulet, MA (通讯作者)，Inst Salud Carlos III, Ctr Invest Biomed Red Fisiopatol Obes & Nutr CIBER, Madrid 28029, Spain. EM mazulet@unav.es RI Benito, Alberto/AAD-4201-2020; Riezu-Boj, Jose-Ignacio/M-3748-2014; Tur, Josep/AAE-5748-2020; Tobaruela Resola, Ana Luz/MIO-9814-2025; Milagro, Fermin/F-2315-2015; Carlón, Mariana/ABD-5128-2021 OI Benito, Alberto/0000-0002-1527-0092; Mogna-Peláez, Paola/0000-0001-6058-312X; Riezu-Boj, Jose-Ignacio/0000-0002-1885-8457; Tur, Josep/0000-0002-6940-0761; Herrero, J Ignacio/0000-0002-9076-6717; Elorz Carlón, Mariana/0000-0002-1580-3629; Tobaruela Resola, Ana Luz/0009-0008-4484-8819; FU Health Department of the Government of Navarra [61/2015, PC082-083-084]; CIBERobn (Physiology of Obesity and Nutrition) [CB12/03/30002, CB12/03/30038]; Fundacio La Marato de TV3 [201630.10]; Centre for Nutrition Research (CIN) of the University of Navarra; CRUE-CSIC; Springer Nature FX This research was funded by the Health Department of the Government of Navarra, with the FLiO (61/2015) and EHGNA (PC082-083-084) projects, CIBERobn (Physiology of Obesity and Nutrition, CB12/03/30002 and CB12/03/30038), Fundacio La Marato de TV3 (201630.10), and the Centre for Nutrition Research (CIN) of the University of Navarra.Open Access funding provided thanks to the CRUE-CSIC agreement with Springer Nature. 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Endocrinol. Invest. PD APR PY 2025 VL 48 IS 4 BP 987 EP 1003 DI 10.1007/s40618-024-02499-9 EA NOV 2024 PG 17 WC Endocrinology & Metabolism WE Science Citation Index Expanded (SCI-EXPANDED) SC Endocrinology & Metabolism GA 0SA1A UT WOS:001355669300001 PM 39549213 OA Green Submitted, hybrid DA 2026-02-02 ER PT J AU Mullin, SM Kelly, AJ Chathail, MN Norris, S Shannon, CE Roche, HM AF Mullin, Sinead M. Kelly, Aidan J. Chathail, Meabh Ni Norris, Suzanne Shannon, Christopher E. Roche, Helen M. TI Macronutrient Modulation in Metabolic Dysfunction-Associated Steatotic Liver Disease-the Molecular Role of Fatty Acids compared with Sugars in Human Metabolism and Disease Progression SO ADVANCES IN NUTRITION LA English DT Review DE MASLD; MASH; inflammation; fibrosis; fatty acids; carbohydrates; sugars; fiber; dietary intervention; precision nutrition ID ENDOPLASMIC-RETICULUM STRESS; INFLAMMATORY EXTRACELLULAR VESICLES; INSULIN-RESISTANCE PHENOTYPE; STELLATE CELL ACTIVATION; HEPATIC STEATOSIS; OXIDATIVE STRESS; KETOGENIC DIET; MEDITERRANEAN DIET; RISK-FACTORS; NONALCOHOLIC STEATOHEPATITIS AB Metabolic dysfunction-associated steatotic liver disease (MASLD) is a significant public health concern, with its progression to metabolic dysfunction-associated steatohepatitis (MASH) and fibrosis leading to severe outcomes including cirrhosis, hepatocellular carcinoma, and liver failure. Whereas obesity and excess energy intake are well-established contributors to the development and progression of MASLD, the distinct role of specific macronutrients is less clear. This review examines the mechanistic pathways through which dietary fatty acids and sugars contribute to the development of hepatic inflammation and fibrosis, offering a nuanced understanding of their respective roles in MASLD progression. In terms of addressing potential therapeutic options, human intervention studies that investigate whether modifying the intake of dietary fats and carbohydrates affects MASLD progression are reviewed. By integrating this evidence, this review seeks to bridge the gap in the understanding between the mechanisms of macronutrient-driven MASLD progression and the effect of altering the intake of these nutrients in the clinical setting and presents a foundation for future research into targeted dietary strategies for the treatment of the disease. C1 [Mullin, Sinead M.; Chathail, Meabh Ni; Roche, Helen M.] Univ Coll Dublin, Sch Publ Hlth Physiotherapy & Sport Sci, Dublin, Ireland. [Mullin, Sinead M.; Chathail, Meabh Ni; Roche, Helen M.] Univ Coll Dublin, Inst Food & Hlth, Dublin, Ireland. [Mullin, Sinead M.; Chathail, Meabh Ni; Shannon, Christopher E.; Roche, Helen M.] Univ Coll Dublin, UCD Conway Inst, Nutrigen Res Grp, Dublin, Ireland. [Kelly, Aidan J.; Norris, Suzanne] Trinity Coll Dublin, Sch Med, Dublin, Ireland. [Shannon, Christopher E.] Univ Coll Dublin, Sch Med, Dublin, Ireland. [Roche, Helen M.] Queens Univ Belfast, Inst Global Food Secur, Belfast, North Ireland. C3 University College Dublin; University College Dublin; University College Dublin; Trinity College Dublin; University College Dublin; Queens University Belfast RP Roche, HM (通讯作者)，Univ Coll Dublin, Sch Publ Hlth Physiotherapy & Sport Sci, Dublin, Ireland.; Roche, HM (通讯作者)，Univ Coll Dublin, Inst Food & Hlth, Dublin, Ireland.; Roche, HM (通讯作者)，Univ Coll Dublin, UCD Conway Inst, Nutrigen Res Grp, Dublin, Ireland.; Roche, HM (通讯作者)，Queens Univ Belfast, Inst Global Food Secur, Belfast, North Ireland. EM helen.roche@ucd.ie RI ; Kelly, Aidan/JVZ-7359-2024; Shannon, Chris/JXN-4737-2024 OI Mullin, Sinéad/0009-0009-2242-8589; Roche, Helen/0000-0002-0628-3318; Kelly, Aidan/0000-0002-7476-9125; Shannon, Chris/0000-0003-0240-0609 FU Science Foundation Ireland Frontiers Award Programme [SFI 19/FFP/6625]; Higher Education Authority of Ireland COVID-19 Research Extension Response Award FX This work was supported by Science Foundation Ireland Frontiers Award Programme (SFI 19/FFP/6625) and the Higher Education Authority of Ireland COVID-19 Research Extension Response Award. 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Nutr. PD MAR PY 2025 VL 16 IS 3 AR 100375 DI 10.1016/j.advnut.2025.100375 EA FEB 2025 PG 23 WC Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Nutrition & Dietetics GA X5K7T UT WOS:001425742900001 PM 39842721 OA Green Submitted, hybrid DA 2026-02-02 ER PT J AU Liu, XL Chang, Y Jia, F Li, YG Wang, Y Cui, JW AF Liu, Xiangliang Chang, Yu Jia, Feng Li, Yuguang Wang, Yao Cui, Jiuwei TI Association of Life's Essential 8 with metabolic dysfunction-associated steatotic liver disease (MASLD), a cross-sectional study from the NHANES 2003-2018 SO SCIENTIFIC REPORTS LA English DT Article DE Life's Essential 8 (LE8); Metabolic dysfunction-associated steatotic liver disease (MASLD); Cardiovascular Health (CVH); Weighted quantile sum regression (WQS) model; Restrictive cubic spline (RCS); NHANES ID AMERICAN HEART ASSOCIATIONS; CARDIOVASCULAR-DISEASE; MEDITERRANEAN DIET; HEALTH; PREVALENCE; INDEX; COST; RISK AB There is limited research on the relationship between Life's Essential 8 (LE8) score and metabolic dysfunction-associated steatotic liver disease (MASLD). Our aim is to investigate the relationship between overall lifestyle assessed by LE-8 score and MASLD in a nationally representative sample. We employed the LE8 score to comprehensively evaluate cardiovascular health, the assessment of MASLD primarily utilized the Fatty Liver Index. The weighted logistic regression models, restrictive cubic splines (RCS), subgroup analyses and the weighted quantile sum (WQS) regression were used to evaluate the relationship between the cardiovascular health and MASLD. Logistic regression models revealed that higher LE8 scores were associated with lower odds of having MASLD. The RCS revealed a significant nonlinear dose-response relationship between LE8 scores and MASLD. The WQS regression model indicated that blood glucose contributed the most to the risk of MASLD. The subgroup analysis indicates that there are significant differences in this association across age, educational level, and poverty income ratio. Our study suggests that an inverse correlation between LE8 and the risk of MASLD. Our findings underscore the utility of the LE8 algorithm in MASLD risk assessment and provide support for MASLD prevention through the promotion of healthy lifestyles. C1 [Liu, Xiangliang; Chang, Yu; Jia, Feng; Li, Yuguang; Wang, Yao; Cui, Jiuwei] First Hosp Jilin Univ, 1 Xinmin St, Changchun, Peoples R China. C3 Jilin University RP Cui, JW (通讯作者)，First Hosp Jilin Univ, 1 Xinmin St, Changchun, Peoples R China. 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Management of MASLD mostly relies on lifestyle change aiming at improving metabolic homeostasis and insulin resistance. A Mediterraneanlike dietary pattern and individualized lifestyle interventions are the cornerstone of MASLD treatment. A careful evaluation of alcohol intake and active treatment of all metabolic co -morbidities are recommended. In the MASLD spectrum, the population with liver inflammation and enhanced fibrogenesis (MASH - Metabolicdysfunction associated steatohepatitis) can progress to advanced liver disease and has been addressed as "atrisk MASH", eligible to pharmacological treatment according to FDA and EMA. Currently there is a robust therapeutic pipeline across a variety of new targets to resolve MASH or reverse fibrosis, or both. Some of these therapies have beneficial effects that extend beyond the liver, such as effects on glycaemic control, lipid profile and weight loss. For "at -risk" MASH, reversal of fibrosis by one stage or resolution of MASH with no worsening in fibrosis as a surrogate end -point will need to be accompanied by overall survival benefits. In this review, we summarize the current evidence on lifestyle interventions in MASLD as well as pharmacological approaches for fibrosing MASH that have progressed to phase II and phase III clinical trials. C1 [Armandi, Angelo; Bugianesi, Elisabetta] Univ Turin, Dept Med Sci, Div Gastroenterol, Turin, Italy. C3 University of Turin RP Armandi, A (通讯作者)，Univ Turin, Dept Med Sci, Corso Dogliotti 14, I-10126 Turin, Italy. 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PD APR PY 2024 VL 122 BP 20 EP 27 DI 10.1016/j.ejim.2024.01.005 EA APR 2024 PG 8 WC Medicine, General & Internal WE Science Citation Index Expanded (SCI-EXPANDED) SC General & Internal Medicine GA ZG1I4 UT WOS:001274046500002 PM 38262842 OA Bronze DA 2026-02-02 ER PT J AU Ueba, Y Ikeda, M Tabara, Y Naiayama, T Tanaka, D Takahashi, Y Kosuci, S Setoh, K Kawaguchi, T Matsuda, F Inagaki, N AF Ueba, Yoko Ikeda, Maori Tabara, Yasuharu Naiayama, Takeo Tanaka, Daisuke Takahashi, Yoshimitsu Kosuci, Shinji Setoh, Kazuya Kawaguchi, Takahisa Matsuda, Fumihiko Inagaki, Nobuya TI Dietary Patterns Rich in Soybean Products, Vegetables, Fish, Fruits, and Miso Soup Were Inversely Associated with Fatty Liver Index: The Nagahama Study SO JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY LA English DT Article DE dietary patterns; fatty liver index; Japanese diet; longitudinal cohort study; metabolic dysfunction-associated steatotic liver disease ID BLOOD-PRESSURE; LIFE-STYLE; DISEASE; STATEMENT; FIBROSIS; SODIUM AB Metabolic dysfunction-associated steatotic liver disease (MASLD) is a prominent liver disease occurring in approximately 25% of the general population. As treatment, lifestyle modification is essential, but there are few reports on dietary patterns associated with MASLD except for the Mediterranean diet. This study examines dietary habits related to MASLD using the fatty liver index (FLI). Longitudinal analysis of a community-based cohort, the Nagahama Prospective Cohort for Comprehensive Human Bioscience, was performed. Dietary habits were assessed by a self-reported questionnaire on food intake frequency, and factor analysis was applied to identify dietary patterns. Multiple regression analysis was performed with baseline FLI or FLI after 5 y as the dependent variable and sex, age, and/or baseline FLI, and factor scores of each dietary pattern as simultaneous independent variables. The same analyses stratified by sex or body mass index (BMI) were also performed. Three thousand five hundred one participants were included. The 15 food items of the questionnaire were summarized into four dietary patterns. Dietary patterns rich in soybean products, vegetables, fish, fruits, and miso soup, which is characteristic of traditional Japanese diet, negatively correlated with FLI and FLI after 5 y (partial regression coefficient: -3.01 and -1.03, respectively; p<0.01 for both). The result was similar in sex-specific analysis and in BMI<23 kg/m(2) group, when the participants were stratified according to BMI. Our results suggest that dietary patterns rich in soybean products, vegetables, fish, fruits, and miso soup are protective factors against MASLD especially in individuals with BMI<23 kg/m(2). C1 [Ueba, Yoko; Ikeda, Maori; Tanaka, Daisuke; Inagaki, Nobuya] Kyoto Univ, Grad Sch Med, Dept Diabet Endocrinol & Nutr, 54 Shogoin Kawaharacho,Sakyo Ku, Kyoto 6068507, Japan. [Ikeda, Maori] Kyoto Univ Hosp, Inst Advancement Clin & Translat Sci, Dept Clin Res Facilitat, 54 Shogoin Kawaharacho,Sakyo Ku, Kyoto 6068507, Japan. [Tabara, Yasuharu; Setoh, Kazuya] Kyoto Univ, Ctr Genom Med, Grad Sch Med, 53 Shogoin Kawaramachi,Sakyo Ku, Kyoto 6068507, Japan. [Tabara, Yasuharu; Setoh, Kazuya] Shizuoka Grad Univ Publ Hlth, Grad Sch Publ Hlth, 4-27-2 Kitaando,Aoi Ku, Shizuoka 4200881, Japan. [Naiayama, Takeo; Takahashi, Yoshimitsu] Kyoto Univ, Sch Publ Hlth, Dept Hlth Informat, Sakyo Ku, Kyoto 6068501, Japan. [Kosuci, Shinji] Kyoto Univ, Dept Med Eth & Med Genet, Sch Publ Hlth, Sakyo Ku, Kyoto 6068501, Japan. [Inagaki, Nobuya] Med Res Inst KITANO HOSP, PIIF Tazuke Kofukai, 2-4-20 Ogimachi,Kita Ku, Osaka 5308480, Japan. C3 Kyoto University; Kyoto University; Kyoto University; Kyoto University; Kyoto University; Kitano Hospital RP Inagaki, N (通讯作者)，Kyoto Univ, Grad Sch Med, Dept Diabet Endocrinol & Nutr, 54 Shogoin Kawaharacho,Sakyo Ku, Kyoto 6068507, Japan.; Inagaki, N (通讯作者)，Med Res Inst KITANO HOSP, PIIF Tazuke Kofukai, 2-4-20 Ogimachi,Kita Ku, Osaka 5308480, Japan. EM inagaki@kuhp.kyoto-u.ac.jp RI Inagaki, Nobuya/IVV-3659-2023; Takahashi, Yoshimitsu/J-4664-2016 FU Ministry of Education, Culture, Sports, Science and Technology in Japan [23659352, 26670313, 25293141, 26293198]; Japan Science and Technology Agency; Practical Research Project for Rare/Intractable Diseases [Aek010907]; Japan Agency for Medical Research and Development (AMED) [Adk207006]; Takeda Science Foundation; AMED [JP231e0110021]; [JP23KJ1278]; Grants-in-Aid for Scientific Research [22K07469, 23KJ1278, 21H04850] Funding Source: KAKEN FX This study was supported by a University Grant and a Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology in Japan [grant number 23659352, 26670313, 25293141 and 26293198] , the Center of Innovation Program and the Global University Project from Japan Science and Technology Agency, the Practical Research Project for Rare/Intractable Diseases [grant number Aek010907] , the Comprehensive Research on Aging and Health Science Research Grants for Dementia R&D [grant number Adk207006] from Japan Agency for Medical Research and Development (AMED) , and a research grant from the Takeda Science Foundation. This research was also supported by AMED under Grant Number JP231e0110021 and Grant-in-Aid for Japan Society for the Promotion of Science (JSPS) Fellows Grant Number JP23KJ1278. 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Nutr. Sci. Vitaminol. PY 2025 VL 71 IS 1 BP 25 EP 33 DI 10.3177/jnsv.71.25 PG 9 WC Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Nutrition & Dietetics GA Z1R9E UT WOS:001436775200003 PM 40024746 OA gold DA 2026-02-02 ER PT J AU Zelber-Sagi, S Carrieri, P Pericas, JM Ivancovsky-Wajcman, D Younossi, ZM Lazarus, JV AF Zelber-Sagi, Shira Carrieri, Patrizia Pericas, Juan M. Ivancovsky-Wajcman, Dana Younossi, Zobair M. Lazarus, Jeffrey V. TI Food inequity and insecurity and MASLD: burden, challenges, and interventions SO NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY LA English DT Review ID FATTY LIVER-DISEASE; ALCOHOL-CONSUMPTION; MEDITERRANEAN DIET; SOCIAL DETERMINANTS; ETHNIC DISPARITIES; METABOLIC SYNDROME; PRACTICE GUIDANCE; RISK-FACTORS; HEALTH; OBESITY AB Liver disease prevalence, severity, outcomes and hepatic risk factors (for example, unhealthy diet) are heavily affected by socioeconomic status and food insecurity. Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most prevalent liver disease globally and is likely to co-occur with other liver diseases associated with food insecurity. Though weight reduction and adopting a healthy diet can reverse the course of MASLD, gaps between recommendations and practice transcend individual responsibility and preference. Broader sociocultural determinants of food choices (social nutrition) include food insecurity, community and social norms and the local environment, including commercial pressures that target people experiencing poverty, ethnic minorities and children. Food insecurity is a barrier to a healthy diet, as a low-quality diet is often less expensive than a healthy one. Consequently, food insecurity is an 'upstream' risk factor for MASLD, advanced fibrosis and greater all-cause mortality among patients with liver disease. Intervening on food insecurity at four major levels (environment, policy, community and health care) can reduce the burden of liver disease, thereby reducing social and health inequities. In this Review, we report on the current research in the field, the need for implementing proven interventions, and the role liver specialists can have. Metabolic dysfunction-associated steatotic liver disease (MASLD) prevalence is increasing worldwide, and a crucial risk factor is food insecurity. This Review provides an extensive overview of food insecurity in the context of MASLD and discusses potential policies and procedures as interventions. Socially deprived communities bear the brunt of the increasing prevalence of liver disease, especially metabolic dysfunction-associated steatotic liver disease (MASLD), which is affected by social nutrition factors.Socioeconomic disparities in liver disease are partially explained by disparities in major hepatic risk factors (for example, unhealthy diet, tobacco use, alcohol consumption and physical inactivity).The unequal challenges in maintaining a healthy diet are related to social and commercial determinants of health, including food insecurity, all of which can be reduced through a systems approach.Liver specialists must address food insecurity and limited availability of accessible and affordable nutritious food, which, coupled with low food literacy and aggressive marketing, lead to over-consumption of low-quality food.To respond to the MASLD burden, the liver community needs to address food insecurity in the community and clinical care settings with 'food is medicine' and a social prescribing approach.Bringing together multiple disciplines, including hepatology, social sciences, mental health and nutrition, with the support of the health system and policy, is needed to address health disparities such as food insecurity. C1 [Zelber-Sagi, Shira] Univ Haifa, Fac Social Welf & Hlth Sci, Sch Publ Hlth, Haifa, Israel. [Zelber-Sagi, Shira; Younossi, Zobair M.; Lazarus, Jeffrey V.] Global NASH Council, Washington, DC 20037 USA. [Carrieri, Patrizia] Aix Marseille Univ, Inserm, IRD, SESSTIM,Sci Econ & Sociales Sante & Traitement Inf, Marseille, France. [Pericas, Juan M.] Univ Autonoma Barcelona, Vall Dhebron Univ Hosp, Vall Dhebron Inst Res, Liver Unit,CIBERehd, Barcelona, Spain. [Pericas, Juan M.] Johns Hopkins Univ Pompeu Fabra Univ Publ Policy C, Barcelona, Spain. [Ivancovsky-Wajcman, Dana; Lazarus, Jeffrey V.] Univ Barcelona, Hosp Clin, Barcelona Inst Global Hlth ISGlobal, Barcelona, Spain. [Younossi, Zobair M.] Inova Hlth Syst, Beatty Liver & Obes Res Program, Falls Church, VA USA. [Lazarus, Jeffrey V.] CUNY Grad Sch Publ Hlth & Hlth Policy SPH, New York, NY USA. C3 University of Haifa; Institut de Recherche pour le Developpement (IRD); Aix-Marseille Universite; Institut National de la Sante et de la Recherche Medicale (Inserm); Hospital Universitari Vall d'Hebron; Autonomous University of Barcelona; CIBER - Centro de Investigacion Biomedica en Red; CIBEREHD; ISGlobal; University of Barcelona; Hospital Clinic de Barcelona; Inova Health System RP Zelber-Sagi, S (通讯作者)，Univ Haifa, Fac Social Welf & Hlth Sci, Sch Publ Hlth, Haifa, Israel.; Zelber-Sagi, S (通讯作者)，Global NASH Council, Washington, DC 20037 USA. EM szelber-s@univ.haifa.ac.il RI Carrieri, Patrizia/LZG-7375-2025; Ivancovsky-Wajcman, Dana/HDO-6146-2022; Pericas, Juan M/N-5674-2019; Lazarus, Jeffrey V/R-6248-2018; Younossi, Zobair M./JRY-9916-2023 OI Carrieri, Patrizia/0000-0002-6794-4837; Pericas, Juan M/0000-0002-3645-3293; Lazarus, Jeffrey V/0000-0001-9618-2299; FU Institution: Beatty Liver and Obesity Research Program, Inova Health System, Falls Church, Virginia; Global NASH Council, Washington, DC; IS Global - MCIN/AEI [CEX2018-000806-S]; Generalitat de Catalunya FX The authors thank J. M. Paik for performing descriptive analysis with visualizations (Figs. 1 and 2). Institution: Beatty Liver and Obesity Research Program, Inova Health System, Falls Church, Virginia, The Global NASH Council, Washington, DC. This work received no funding. D.I.W. and J.V.L. acknowledge support to IS Global from the grant CEX2018-000806-S funded by MCIN/AEI/10.13039/501100011033 and the Generalitat de Catalunya through the CERCA Programme, outside the submitted work. 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Rev. Gastroenterol. Hepatol. PD OCT PY 2024 VL 21 IS 10 BP 668 EP 686 DI 10.1038/s41575-024-00959-4 EA JUL 2024 PG 19 WC Gastroenterology & Hepatology WE Science Citation Index Expanded (SCI-EXPANDED) SC Gastroenterology & Hepatology GA H7F0D UT WOS:001279232900001 PM 39075288 DA 2026-02-02 ER PT J AU Duarte, L Magne, F Gotteland, M AF Duarte, Lissette Magne, Fabien Gotteland, Martin TI Gut microbiota in patients with metabolic, dysfunction-associated steatotic liver disease SO CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE LA English DT Article DE bile acids; fecal microbiota transplantation.; gut permeability; short chain fatty acids; trimethylamine-L-oxide AB Purpose of reviewMetabolic dysfunction-associated steatotic liver disease (MASLD) is a highly prevalent condition that can progress to fibrosis, steatohepatitis, and hepatocellular carcinoma. This review examines recent advances concerning the role of gut microbiota in MASLD and microbiota-focused interventions to positively impact disease outcome.Recent findingsDysbiotic microbiota and a compromised gut barrier facilitate the translocation of microbial-associated molecular patterns and harmful metabolites into the portal circulation and liver, where they exacerbate inflammatory and fibrogenic processes. Conversely, other bacterial metabolites have protective effects in the liver. Therefore, microbiota homeostasis is essential for maintaining liver health.SummaryLevels of harmful bacterial metabolites including ethanol, NH3, trimethylamine-L-oxide, 2-oleylglycerol, and litocholic acid are often increased in patients with MASLD. Conversely, short-chain fatty acids, indole derivatives, histidine, and the acids taurodeoxycholic, 3-succinylcholic, and hyodeoxycholic are decreased. The main aim of current interventions/treatments is to reduce harmful metabolites and increase beneficial ones. These interventions include drugs (pemafibrate, metformin, obeticholic acid), natural compounds (silymarin, lupeol, dietary fiber, peptides), exogenous bacteria (probiotics, gut symbionts), special diets (Mediterranean diet, time-restricted feeding), as well as microbiota transplantation, and phage therapy. Most improve gut permeability, liver inflammation, and fibrosis through microbiota regulation, and are promising alternatives for MASLFD management. However, most results come from animal studies, while clinical trials in MASLD patients are lacking. Further research is therefore needed in this area. C1 [Duarte, Lissette; Gotteland, Martin] Univ Chile, Dept Nutr, Santiago, Chile. [Magne, Fabien] Univ Chile, Fac Med, Microbiol & Mycol Program, ICBM, Santiago, Chile. [Gotteland, Martin] Univ Chile, Inst Nutr & Food Technol INTA, Santiago, Chile. C3 Universidad de Chile; Universidad de Chile; Universidad de Chile RP Gotteland, M (通讯作者)，Univ Chile, Fac Med, Dept Nutr, Independencia 1027, Santiago, Chile. 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Care PD JUL PY 2025 VL 28 IS 4 BP 307 EP 315 DI 10.1097/MCO.0000000000001128 PG 9 WC Endocrinology & Metabolism; Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Endocrinology & Metabolism; Nutrition & Dietetics GA 3MB5G UT WOS:001503584000004 PM 40294087 DA 2026-02-02 ER PT J AU De Nucci, S Bonfiglio, C Donvito, R Di Chito, M Cerabino, N Rinaldi, R Sila, A Shahini, E Giannuzzi, V Pesole, PL Coletta, S Lanzilotta, E Piazzolla, G Cozzolongo, R Giannelli, G De Pergola, G AF De Nucci, Sara Bonfiglio, Caterina Donvito, Rosanna Di Chito, Martina Cerabino, Nicole Rinaldi, Roberta Sila, Annamaria Shahini, Endrit Giannuzzi, Vito Pesole, Pasqua Letizia Coletta, Sergio Lanzilotta, Elsa Piazzolla, Giuseppina Cozzolongo, Raffaele Giannelli, Gianluigi De Pergola, Giovanni TI Effects of an Eight Week Very Low-Calorie Ketogenic Diet (VLCKD) on White Blood Cell and Platelet Counts in Relation to Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) in Subjects with Overweight and Obesity SO NUTRIENTS LA English DT Article DE white blood cell (WBC); platelets (PLT); non-alcoholic fatty liver disease (NAFLD); metabolic dysfunction-associated steatotic liver disease (MASLD); very low-calorie ketogenic diet (VLCKD); obesity; insulin resistance; transient elastography (FibroScan) ID MEDITERRANEAN DIET; MANAGEMENT; INFLAMMATION; GUIDELINES AB Obesity and metabolic dysfunction-associated steatotic liver disease (MASLD) are frequently associated conditions characterized by low-grade inflammation. Very low-calorie ketogenic diet (VLCKD) strategies are commonly used to simultaneously obtain weight loss and an improvement of liver steatosis. We evaluated the efficacy of 8 weeks' VLCKD in decreasing the white blood cell (WBC) and platelet (PLT) counts, as well as liver steatosis and fibrosis, diagnosed using transient elastography (FibroScan). Metabolic and anthropometric parameters commonly associated with MASLD were also evaluated. This study included 87 participants; 58 women and 29 men aged between 18 and 64 years with overweight (18%) or obesity (82%), but not taking any medication. Anthropometric measurements, bioimpedance analysis, and biochemical assays were performed before and after the dietary intervention. BMI (kg/m(2)) (p-value < 0.001), waist circumference (cm) (p-value < 0.001), and fat mass (kg) (p-value < 0.001) were significantly decreased following VLCKD. After VLCKD, the FibroScan parameter CAP (db/m), which measures the accumulation of fatty liver, significantly decreased (p-value < 0.001), as did liver stiffness (kPA), the FibroScan parameter quantifying liver fibrosis (p-value < 0.05). Seemingly, WBC (p-value < 0.001) and PLT (p-value < 0.001) counts were lowered by VLCKD in the whole group; however, the decrease in WBC and platelet counts were significant only in patients with steatosis (CAP >= 215 dB/m). Fasting blood glucose (p-value < 0.001), insulin (p-value < 0.001), HbA1c (p-value < 0.001), triglycerides (p-value < 0.001), total cholesterol (p-value < 0.001), LDL-cholesterol (p-value < 0.001), HDL-cholesterol (p-value < 0.001); gamma GT (p-value < 0.001) blood levels and insulin resistance (as measured by HOMAIR) (p-value < 0.001); and systolic (p-value < 0.001), and diastolic (p-value < 0.001) blood pressure levels, were all significantly lower after VLCKD. In contrast, blood levels of vitamin D were higher following the diet (p-value < 0.001). We conclude that treating subjects with overweight and obesity with VLCKD is followed by a simultaneous reduction in WBCs and platelets, the expression of low-grade inflammation, and of liver steatosis and fibrosis. Therefore, we can hypothesize that VLCKD decreases general and liver low-grade inflammation, thus improving liver health. C1 [De Nucci, Sara; Donvito, Rosanna; Di Chito, Martina; Cerabino, Nicole; Rinaldi, Roberta; Sila, Annamaria; De Pergola, Giovanni] Natl Inst Gastroenterol IRCCS Saverio de Bellis, Ctr Nutr Res & Care Obes & Metab Dis, I-70013 Castellana Grotte, Italy. [Bonfiglio, Caterina] IRCCS Hosp, Natl Inst Gastroenterol Saverio de Bellis, Lab Epidemiol & Stat, I-70013 Bari, Italy. [Shahini, Endrit; Giannuzzi, Vito; Cozzolongo, Raffaele] IRCCS Hosp, Natl Inst Gastroenterol Saverio de Bellis, Dept Gastroenterol, I-70013 Bari, Italy. [Pesole, Pasqua Letizia; Coletta, Sergio] IRCCS Hosp, Natl Inst Gastroenterol de Saverio, Core Facil Biobank, I-70013 Bari, Italy. [Lanzilotta, Elsa] IRCCS Hosp, Natl Inst Gastroenterol Saverio de Bellis, Lab Clin Pathol, I-70013 Bari, Italy. [Piazzolla, Giuseppina] Univ Bari Aldo Moro, Sch Med, Interdisciplinary Dept Med, Piazza Giulio Cesare 11, I-70124 Bari, Italy. [Giannelli, Gianluigi] IRCCS Hosp, Natl Inst Gastroenterol Saverio de Bellis, Sci Direct, I-70013 Bari, Italy. C3 Universita degli Studi di Bari Aldo Moro RP De Pergola, G (通讯作者)，Natl Inst Gastroenterol IRCCS Saverio de Bellis, Ctr Nutr Res & Care Obes & Metab Dis, I-70013 Castellana Grotte, Italy. EM roberta.rinaldi@irccsdebellis.it; endrit.shahini@irccsdebellis.it; giuseppina.piazzolla@uniba.it; gianluigi.giannelli@irccsdebellis.it; giovanni.depergola@irccsdebellis.it RI Shahini, Enit/AAX-7646-2021; Giannelli, Gianluigi/A-8169-2012; cozzolongo, raffaele/ABH-5696-2020; DiChito, Martina/MCJ-9296-2025; Piazzolla, Giuseppina/JEO-7179-2023 OI Shahini, Enit/0000-0002-4909-0436; Rinaldi, Roberta/0000-0002-3817-8643; pesole, pasqua letizia/0000-0003-4675-2075; Giannelli, Gianluigi/0000-0002-5140-8060; Bonfiglio, Caterina/0000-0002-8650-348X; Piazzolla, Giuseppina/0000-0003-3221-6562 FU The authors thank all the participants and investigators for their efforts. We are also grateful to Mary Pragnell, B.A., for language revision. FX The authors thank all the participants and investigators for their efforts. We are also grateful to Mary Pragnell, B.A., for language revision. 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SO NUTRIENTS LA English DT Article DE gut microbiota; nonalcoholic fatty liver disease; fiber; short-chain fatty acids ID MEDITERRANEAN DIET; STEATOSIS; SCFAS; NAFLD AB Background: The occurrence of metabolic dysfunction-associated steatotic liver disease (MASLD) is a growing global problem which commonly affects patients with co-existing diseases/conditions, such as type 2 diabetes and dyslipidemia. The effective treatment of MASLD is still limited; however, diet plays a significant role in its management. There are multiple beneficial properties of dietary fiber, including its ability to modify the gut microbiome. Therefore, the aim of this study was to determine the effect of the consumption of fiber-enriched rolls on the gut microbiome and microbial metabolites in patients suffering from MASLD. Methods: The participants were recruited according to the inclusion criteria and were required to consume fiber-enriched rolls containing either 6 g or 12 g of fiber. There were three assessment timepoints, when the anthropometric and laboratory parameters were measured, and 16s on nanopore sequencing of the fecal microbiome was conducted. Results: Firmicutes and Bacteroidetes were the most abundant phyla in the patients living with MASLD. It was demonstrated that the amount of short-chain fatty acids (SCFAs) changed after the consumption of fiber-enriched rolls; however, this was strongly associated with both the timepoint and the type of SCFAs-acetate and butyrate. Additionally, the high-fiber diet was related to the increase in phyla diversity (p = 0.006571). Conclusions: Overall, the introduction of an appropriate amount of fiber to the diet seems to be promising for patients suffering from MASLD due to its ability to create an improvement in gut microbiome-related aspects. C1 [Kazmierczak-Siedlecka, Karolina] Med Univ Gdansk, Dept Med Lab Diagnost, Fahrenheit Biobank BBMRIpl, PL-80211 Gdansk, Poland. [Maciejewska-Markiewicz, Dominika; Jakubczyk, Karolina; Janda-Milczarek, Katarzyna; Stachowska, Ewa] Pomeranian Med Univ, Dept Human Nutr & Metabol, PL-71460 Szczecin, Poland. [Sykulski, Maciej] Med Univ Warsaw, Dept Med Genet, PL-02106 Warsaw, Poland. [Gruszczynska, Agata] Washington Univ, Sch Med, Dept Med, Div Oncol, St Louis, MO 63110 USA. [Herman-Izycka, Julia] GenXone SA, Ul Kobaltowa 6, PL-62002 Zlotniki, Poland. [Wylezol, Mariusz] Med Univ Warsaw, Dept Gen Vasc & Oncol Surg, PL-02091 Warsaw, Poland. [Petriczko, Karolina Katarzyna] Pomeranian Med Univ, Translat Med Grp, PL-70204 Szczecin, Poland. [Petriczko, Karolina Katarzyna] SPWSZ Hosp, Dept Gastroenterol & Internal Med, PL-71455 Szczecin, Poland. [Palma, Joanna; Skonieczna-Zydecka, Karolina] Pomeranian Med Univ, Dept Biochem Sci, Broniewskiego 24, Szczecin, Poland. C3 Fahrenheit Universities; Medical University Gdansk; Pomeranian Medical University; Medical University of Warsaw; Washington University (WUSTL); Medical University of Warsaw; Pomeranian Medical University; Pomeranian Medical University RP Stachowska, E (通讯作者)，Pomeranian Med Univ, Dept Human Nutr & Metabol, PL-71460 Szczecin, Poland.; Skonieczna-Zydecka, K (通讯作者)，Pomeranian Med Univ, Dept Biochem Sci, Broniewskiego 24, Szczecin, Poland. EM karolina.skonieczna.zydecka@pum.edu.pl; ewa.stachowska@pum.edu.pl RI Jakubczyk, Karolina/AAE-7408-2020; Maciejewska, Dominika/AAJ-7454-2020; Janda-Milczarek, Katarzyna/T-9565-2018; Stachowska, Ewa/G-9521-2017; Palma, Joanna/AAE-7293-2020; Skonieczna-Żydecka, Karolina/K-7252-2014 OI Jakubczyk, Karolina/0000-0002-5853-9709; Kaźmierczak- Siedlecka, Karolina/0000-0002-0283-1436; Janda-Milczarek, Katarzyna/0000-0002-4548-3419; Stachowska, Ewa/0000-0002-4009-1977; Gruszczyńska, Agata/0000-0002-7877-8002; Palma, Joanna/0000-0003-0620-3776; Skonieczna-Żydecka, Karolina/0000-0002-3430-9079 FU Polish National Agency for Academic Exchange FX We want to sincerely thank Anna Wojciechowska-Koz & lstrok;owska and Ewa Wusch for kindly supporting our study at the Sonomed Medical Center in Szczecin and Viktoria Hawry & lstrok;kowicz, Karina Ryterska, and Patrycja Zalewska for advice regarding sample collection. 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Given its complexity, MASLD necessitates a comprehensive multidisciplinary strategy for both prevention and management. Areas covered: Each of the experts who contributed to this review has made an in-depth review of the literature within their field of knowledge using PubMed. This review covers nutrition, physical activity and exercise, type 2 diabetes mellitus, cardiovascular risk factors, psychological approach, and clinical care by hepatologists in MASLD patients. Expert opinion: Adherence to the Mediterranean diet and engagement in exercise have been shown to ameliorate and potentially reverse MASLD. The hepatologist plays a pivotal role in diagnosis, assessment of liver comorbidities, and disease staging, emphasizing lifestyle modification and tailored therapy. Nutritionists are vital in dietary interventions, while specialists in sports medicine are essential for overcoming sedentary lifestyles, requiring fitness evaluations to customize exercise prescriptions. Psychological support addresses social and adherence challenges, enhancing patient management. Additionally, metabolic medicine experts are crucial for managing associated comorbidities, including cardiovascular risk factors and type 2 diabetes. C1 [Lara-Romero, Carmen; Millan-Dominguez, Raquel; Romero-Gomez, Manuel] Inst Biomed Seville IBIS, Virgen Rocio Univ Hosp, Digest Dis Unit, SeLiver Grp, Avda Manuel Siurot S-N, Seville 41013, Spain. [Lara-Romero, Carmen; Millan-Dominguez, Raquel; Romero-Gomez, Manuel] Univ Seville, Dept Med, Seville, Spain. [Fernandez-Gomez, Miguel Angel] Univ Seville, Sports Med Unit, Seville, Spain. [Martin, Franz; Berna, Genoveva] Univ Seville, Pablo Olavide Univ, Andalusian Ctr Mol Biol & Regenerat Med CABIMER, CSIC,CIBERDEM,ISCIII, Seville, Spain. [Castilla-Guerra, Luis] Virgen Macarena Univ Hosp, Dept Internal Med, Cardiovasc Risk Unit, Seville, Spain. [Castilla-Guerra, Luis] Univ Seville, Dept Med, Seville, Spain. [Funuyet-Salas, Jesus] Loyola Andalucia Univ, Psychol Dept, Seville, Spain. C3 Consejo Superior de Investigaciones Cientificas (CSIC); University of Sevilla; CSIC-JA-USE - Instituto de Biomedicina de Sevilla (IBIS); Virgen del Rocio University Hospital; University of Sevilla; University of Sevilla; Instituto de Salud Carlos III; CIBER - Centro de Investigacion Biomedica en Red; CIBERDEM; Consejo Superior de Investigaciones Cientificas (CSIC); Universidad Pablo de Olavide; University of Sevilla; CSIC - Centro Andaluz de Biologia Molecular y Medicina Regenerativa (CABIMER); Hospital Universitario Virgen Macarena; University of Sevilla; Universidad Loyola Andalucia RP Romero-Gomez, M (通讯作者)，Inst Biomed Seville IBIS, Virgen Rocio Univ Hosp, Digest Dis Unit, SeLiver Grp, Avda Manuel Siurot S-N, Seville 41013, Spain. EM mromerogomez@us.es RI Funuyet-Salas, Jesús/W-5332-2018; Berna, Genoveva/AAG-7849-2020 FU Instituto de Salud Carlos III [PI22/01342] FX This study was supported by the Instituto de Salud Carlos III through the research grant PI22/01342, corresponding to the MERGE Project: Combinatorial therapies analysis for the amelioration of Non-alcoholic Fatty Liver Disease. The authors gratefully acknowledge this Funding, which made the development and completion of this work possible. 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Gastroenterol. Hepatol. PD NOV 2 PY 2025 VL 19 IS 11 BP 1153 EP 1165 DI 10.1080/17474124.2025.2584022 PG 13 WC Gastroenterology & Hepatology WE Science Citation Index Expanded (SCI-EXPANDED) SC Gastroenterology & Hepatology GA R1456 UT WOS:001635297800001 PM 41327615 DA 2026-02-02 ER PT J AU Vidal-Cevallos, P Sorroza-Martinez, AP Chavez-Tapia, NC Uribe, M Montalvo-Jave, EE Nuno-Lambarri, N AF Vidal-Cevallos, Paulina Sorroza-Martinez, Adriana P. Chavez-Tapia, Norberto C. Uribe, Misael Montalvo-Jave, Eduardo E. Nuno-Lambarri, Natalia TI The Relationship between Pathogenesis and Possible Treatments for the MASLD-Cirrhosis Spectrum SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES LA English DT Review DE metabolic syndrome; sedentarism; fibrosis; hepatic steatosis; steatohepatitis; diet ID NONALCOHOLIC FATTY LIVER; MEDITERRANEAN DIET; HEPATIC STEATOSIS; PHYSICAL-ACTIVITY; AEROBIC EXERCISE; LOW-CARBOHYDRATE; CARDIOVASCULAR-DISEASE; AMERICAN ASSOCIATION; INSULIN-RESISTANCE; METABOLIC SYNDROME AB Metabolic dysfunction-associated steatotic liver disease (MASLD) is a term that entails a broad spectrum of conditions that vary in severity. Its development is influenced by multiple factors such as environment, microbiome, comorbidities, and genetic factors. MASLD is closely related to metabolic syndrome as it is caused by an alteration in the metabolism of fatty acids due to the accumulation of lipids because of an imbalance between its absorption and elimination in the liver. Its progression to fibrosis is due to a constant flow of fatty acids through the mitochondria and the inability of the liver to slow down this metabolic load, which generates oxidative stress and lipid peroxidation, triggering cell death. The development and progression of MASLD are closely related to unhealthy lifestyle habits, and nutritional epigenetic and genetic mechanisms have also been implicated. Currently, lifestyle modification is the first-line treatment for MASLD and nonalcoholic steatohepatitis; weight loss of >= 10% produces resolution of steatohepatitis and fibrosis regression. In many patients, body weight reduction cannot be achieved; therefore, pharmacological treatment should be offered in particular populations. C1 [Vidal-Cevallos, Paulina; Chavez-Tapia, Norberto C.; Uribe, Misael; Montalvo-Jave, Eduardo E.] Med Sur Clin & Fdn, Obes & Digest Dis Unit, Mexico City 14050, DF, Mexico. [Sorroza-Martinez, Adriana P.; Chavez-Tapia, Norberto C.; Nuno-Lambarri, Natalia] Med Sur Clin & Fdn, Translat Res Unit, Mexico City 14050, DF, Mexico. [Montalvo-Jave, Eduardo E.; Nuno-Lambarri, Natalia] Univ Nacl Autonoma Mexico, Fac Med, Dept Surg, Mexico City 04360, DF, Mexico. [Montalvo-Jave, Eduardo E.] Hosp Gen Mex Dr Eduardo Liceaga, Dept Surg, Hepatopancreatobiliary Clin, Mexico City 06720, DF, Mexico. C3 Universidad Nacional Autonoma de Mexico RP Nuno-Lambarri, N (通讯作者)，Med Sur Clin & Fdn, Translat Res Unit, Mexico City 14050, DF, Mexico.; Nuno-Lambarri, N (通讯作者)，Univ Nacl Autonoma Mexico, Fac Med, Dept Surg, Mexico City 04360, DF, Mexico. EM paulina.vice@gmail.com; paola.sorrozamtz@gmail.com; nchavezt@medicasur.org.mx; muribe@medicasur.org.mx; montalvoeduardo@hotmail.com; nnunol@medicasur.org.mx RI Chavez-Tapia, Norberto/AGJ-9885-2022; Nuño-Lámbarri, Natalia/KBD-4162-2024 OI Chavez-Tapia, Norberto/0000-0002-7451-3306; FU Medica Sur Clinic and Foundation FX We thank the Medica Sur Clinic and Foundation for their support in preparing this manuscript and BioRender.com for their support in creating the figures. 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J. Mol. Sci. PD APR PY 2024 VL 25 IS 8 AR 4397 DI 10.3390/ijms25084397 PG 23 WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary WE Science Citation Index Expanded (SCI-EXPANDED) SC Biochemistry & Molecular Biology; Chemistry GA QJ3J0 UT WOS:001220464800001 PM 38673981 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Salamanca-Sanabria, A Chooi, YC Loo, EXL Lai, XN Volchanskaya, VSB Chong, YS Eriksson, JG AF Salamanca-Sanabria, Alicia Chooi, Yu Chung Loo, Evelyn Xiu Ling Lai, Xianning Volchanskaya, Vera Sergeyevna Brok Chong, Yap Seng Eriksson, Johan Gunnar TI Potential effects of Asian-adapted Mediterranean diet in depression and anxiety among women with metabolic dysfunction-associated steatotic liver disease: a secondary analysis SO FRONTIERS IN NUTRITION LA English DT Article DE MASLD; anxiety; depression; pentadecanoic-acid; Asian-adapted-Mediterranean diet; Singaporean Chinese-female ID FATTY LIVER; PREVENTION; PREVALENCE; PHENOTYPE; SYMPTOMS; WEIGHT AB Background Common Mental Disorders (CMDs) such as anxiety and depression have been associated with metabolic dysfunction-Associated steatotic Liver Disease (MASLD). The Mediterranean Diet (MD) has been shown to improve metabolic health and reduce CMDs. We previously reported that a calorie-restricted MD adapted to the Asian food culture has beneficial effects on body composition, liver fat, and cardiometabolic markers in Chinese Singaporean women with MASLD. Objective This secondary analysis examines the effects of an Asian-adapted MD on the symptoms of anxiety and depression in the same population. Methods In a double-blind, parallel-design, randomized controlled trial, 84 Chinese- Singaporean females with MASLD were randomly assigned to 1 of the 3 groups for 12 weeks: adapted Asian MD with C15:0 supplementation (n = 29), diet without C15:0 supplementation (n = 26), or control (habitual diet and no C15:0 supplementation, n = 29). Depression and anxiety symptoms were assessed using the Beck Inventory Questionnaire (BDI-II) and the State-Trait Anxiety Inventory (STAI). Results Paired t-tests showed a statistically significant reduction in anxiety and depression symptoms within the groups. Particularly, the Diet+C15 group showed a significant decrease in trait anxiety scores (M = 38.62, SE = 1.84 to M = 34.10, SE = 1.73), t (28) = 3.73, p < 0.001, with a medium-to-large effect size (d = 0.69) Jacobson and Truax's reliable change criteria showed clinically reliable improvements in anxiety and depression postintervention. Conclusion The Asian-adapted MD shows potential benefits for reducing anxiety and depression symptoms, particularly trait anxiety in women with MASLD. However, given the complexity of CMD, findings should be interpreted cautiously. Future research with larger sample sizes is needed to confirm these effects and explore underlying mechanisms. Clinical trial registration http://clinicaltrials.gov, NCT05259475. C1 [Salamanca-Sanabria, Alicia; Chooi, Yu Chung; Loo, Evelyn Xiu Ling; Chong, Yap Seng; Eriksson, Johan Gunnar] Agcy Sci Technol & Res, Inst Human Dev & Potential, Singapore, Singapore. [Loo, Evelyn Xiu Ling] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Paediat, Singapore, Singapore. [Loo, Evelyn Xiu Ling] Natl Univ Singapore, Yong Loo Lin Sch Med, Human Potential Translat Res Programme, Singapore, Singapore. [Lai, Xianning; Volchanskaya, Vera Sergeyevna Brok] Natl Univ Singapore, Ctr Translat Med, WIL NUS Corp Lab, Singapore, Singapore. [Chong, Yap Seng; Eriksson, Johan Gunnar] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Obstet & Gynaecol, Singapore, Singapore. [Eriksson, Johan Gunnar] Natl Univ Singapore, Yong Loo Lin Sch Med, Human Potential Translat Res Program, Singapore, Singapore. [Eriksson, Johan Gunnar] Univ Helsinki, Dept Gen Practice & Primary Hlth Care, Helsinki, Finland. [Eriksson, Johan Gunnar] Helsinki Univ Hosp, Helsinki, Finland. [Eriksson, Johan Gunnar] Folkhalsan Res Ctr, Helsinki, Finland. C3 Agency for Science Technology & Research (A*STAR); National University of Singapore; National University of Singapore; National University of Singapore; National University of Singapore; National University of Singapore; University of Helsinki; University of Helsinki; Helsinki University Central Hospital; Folkhalsan Research Center RP Salamanca-Sanabria, A (通讯作者)，Agcy Sci Technol & Res, Inst Human Dev & Potential, Singapore, Singapore. EM salamancas@sics.a-star.edu.sg RI Salamanca-Sanabria, Alicia/IQW-8548-2023 OI Salamanca-Sanabria, Alicia/0000-0002-2756-5592 FU Agency for Science, Technology and Research (A*STAR) under its Industry Alignment Fund - Industry Collaboration Project (IAF-ICP) [I1701E0011] FX The author(s) declare that financial support was received for the research and/or publication of this article. This research is supported by the Agency for Science, Technology and Research (A*STAR) under its Industry Alignment Fund - Industry Collaboration Project (IAF-ICP) funding (Award Number I1701E0011). 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Nutr. PD JUL 8 PY 2025 VL 12 AR 1589412 DI 10.3389/fnut.2025.1589412 PG 11 WC Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Nutrition & Dietetics GA 5DS2B UT WOS:001533237300001 PM 40697557 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Janota, B Janion, K Buzek, A Janczewska, E AF Janota, Barbara Janion, Karolina Buzek, Aneta Janczewska, Ewa TI Dietary Strategies in the Prevention of MASLD: A Comprehensive Review of Dietary Patterns Against Fatty Liver SO METABOLITES LA English DT Review DE MASLD; metabolism; diet; nutrients ID ANTIOXIDANT; MANAGEMENT; STEATOSIS AB Understanding the components of the diet, food groups, and nutritional strategies that help prevent MASLD (Metabolic Dysfunction-Associated Steatotic Liver Disease) is essential for identifying dietary behaviors that can stop the progression of this condition, which currently affects over one-quarter of the global population. This review highlights the importance of including antioxidant nutrients in the diet, such as vitamins C and E, CoQ10, and polyphenolic compounds. It also emphasizes substances that support lipid metabolism, including choline, alpha-lipoic acid, and berberine. Among food groups, it is crucial to choose those that help prevent metabolic disturbances. Among carbohydrate-rich foods, vegetables, fruits, and high-fiber products are recommended. For protein sources, eggs, fish, and white meat are preferred. Among fat sources, plant oils and fatty fish are advised due to their content of omega-3 and omega-6 fatty acids. Various dietary strategies aimed at preventing MASLD should include elements of the Mediterranean diet or be personalized to provide anti-inflammatory compounds and substances that inhibit fat accumulation in liver cells. Other recommended dietary models include the DASH diet, the flexitarian diet, intermittent fasting, and diets that limit fructose and simple sugars. Additionally, supplementing the diet with spirulina or chlorella, berberine, probiotics, or omega-3 fatty acids, as well as drinking several cups of coffee per day, may be beneficial. C1 [Janota, Barbara] Med Univ Silesia, Fac Publ Hlth Bytom, Dept Basic Med Sci, Piekarska 18, PL-41902 Bytom, Poland. [Janion, Karolina] Silesian Coll Med Katowice, Adama Mickiewicza 29, PL-40085 Katowice, Poland. [Buzek, Aneta] Med Univ Silesia, Fac Publ Hlth Bytom, Piekarska 18, PL-41902 Bytom, Poland. [Janczewska, Ewa] ID Clin Myslowice, Janowska 19, PL-41400 Myslowice, Poland. C3 Medical University of Silesia; Medical University of Silesia RP Janota, B (通讯作者)，Med Univ Silesia, Fac Publ Hlth Bytom, Dept Basic Med Sci, Piekarska 18, PL-41902 Bytom, Poland. 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A Mediterranean diet (MD), known for its anti-inflammatory and antioxidant properties, is effective in managing various chronic diseases, including liver diseases. This study aimed to explore the influence of adherence to the MD on the risk of chronic metabolic diseases, including steatotic liver disease (SLD), metabolic dysfunction-associated steatotic liver disease (MASLD), and alcohol-related liver diseases (ALDs). Methods: This retrospective cohort study analyzed 5395 individuals from a single center between 2020 and 2022, grouped by adherence to the MD using the Korean Mediterranean Diet Adherence Score (K-MEDAS). MASLD score, ALD, and cardiovascular risk factors were also assessed. Statistical analyses were performed using 1:1 exact matching and multiple regression to compare the less adherent (K-MEDAS 0-7) and highly adherent (K-MEDAS 8-13) groups. Results: Adjusting for confounding variables, high adherence to the MD was significantly associated with lower rates of SLD (odds ratio [OR] 0.818, 95% confidence interval [CI] 0.700-0.957, p = 0.012), MASLD (OR 0.839, 95% CI 0.714-0.986, p = 0.033), and ALD (OR 0.677, 95% CI 0.671-0.683, p < 0.001). Post-propensity score matching analysis revealed that the highly adherent group exhibited significantly lower triglyceride levels, triglyceride and glucose index, atherogenic Index of Plasma, and Framingham risk scores than the less adherent group. Conclusions: Good adherence to the MD considerably reduces the risk of SLD, MASLD, and ALD, underscoring its protective effects and potential to prevent metabolic liver diseases and their complications. C1 [Lee, Ji Yae; Lee, Ji-Won] Yonsei Univ, Severance Hosp, Coll Med, Dept Family Med, Seoul 03722, South Korea. [Kim, Sue] Yonsei Univ Hlth Syst, Severance Hosp, Int Hlth Care Ctr, Seoul 03722, South Korea. [Lee, Yaeji] Yonsei Univ, Dept Biostat & Comp, Seoul 03722, South Korea. [Kwon, Yu-Jin] Yonsei Univ, Yongin Severance Hosp, Coll Med, Dept Family Med, Yongin 16995, South Korea. [Lee, Ji-Won] Yonsei Univ, Severance Hosp, Dept Family Med, Coll Med,Inst Innovat Digital Healthcare, Yonsei Ro 50-1, Seoul 03722, South Korea. C3 Yonsei University; Yonsei University Health System; Yonsei University; Yonsei University Health System; Yonsei University; Yonsei University; Yonsei University Health System; Yonsei University; Yonsei University Health System RP Lee, JW (通讯作者)，Yonsei Univ, Severance Hosp, Coll Med, Dept Family Med, Seoul 03722, South Korea.; Kwon, YJ (通讯作者)，Yonsei Univ, Yongin Severance Hosp, Coll Med, Dept Family Med, Yongin 16995, South Korea.; Lee, JW (通讯作者)，Yonsei Univ, Severance Hosp, Dept Family Med, Coll Med,Inst Innovat Digital Healthcare, Yonsei Ro 50-1, Seoul 03722, South Korea. EM leelee@yuhs.ac; ladysueya@gmail.com; ysbiostat@yuhs.ac; digda3@yuhs.ac; indi5645@yuhs.ac RI KWON, YUJIN/ACB-8082-2022 OI KWON, YUJIN/0000-0002-9021-3856; LEE, JI WON/0000-0002-2666-4249; Lee, Yaeji/0000-0002-1411-1938; Lee, Yaeji/0000-0002-1411-1938; Lee, Ji Yae/0009-0006-1024-6807 FU Korea Institute of Planning and Evaluation for Technology in Food, Agriculture, and Forestry (IPET); Korea Institute of Planning and Evaluation for Technology in Food, Agriculture, and Forestry (IPET) through the High Value-Added Food Technology Development Program [321030051HD030]; Ministry of Agriculture, Food, and Rural Affairs (MAFRA); National Research Foundation of Korea (NRF) [RS-2024-00354524]; Korean Government FX This research was funded by the Korea Institute of Planning and Evaluation for Technology in Food, Agriculture, and Forestry (IPET) through the High Value-Added Food Technology Development Program, with support from the Ministry of Agriculture, Food, and Rural Affairs (MAFRA) (321030051HD030). This study was also supported by the National Research Foundation of Korea (NRF) grant provided by the Korean Government (RS-2024-00354524). 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Milagro, Fermin I. Herrero, Jose I. Elorz, Mariana Benito-Boillos, Alberto Tobaruela-Resola, Ana Luz Tur, Josep A. Martinez, J. Alfredo Abete, Itziar Zulet, M. Angeles TI Inflammatory markers as diagnostic and precision nutrition tools for metabolic dysfunction-associated steatotic liver disease: Results from the Fatty Liver in Obesity trial SO CLINICAL NUTRITION LA English DT Article DE Inflammation; Diet; MASLD; Obesity; Metabolic dysfunction ID QUESTIONNAIRE; CHOLESTEROL; ULTRASOUND AB Background & aims: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a growing public health concern. The disease is silent, and its diagnosis is often delayed. Inflammatory markers constitute an interesting tool to act as subrogate, non-invasive markers. This study aimed to evaluate the changes of inflammatory markers throughout a two-year dietary intervention in subjects presenting MASLD, to determine which of the markers are suitable to predict the disease, and act as a customizing tool for MASLD's dietary treatment. Methods: Ninety-eight subjects with MASLD and forty-five controls from the Fatty Liver in Obesity (FLiO) Study were analyzed. MASLD was diagnosed and graded by ultrasound. The MASLD subjects were randomly assigned to two different dietary strategies, the American Heart Association (AHA diet) or a dietary strategy based on the Mediterranean pattern, which was specially designed for the study (FLiO diet), and then followed for two years. Hepatic status was additionally assessed through Magnetic Resonance Imaging (MRI), elastography, and determination of transaminases. Results & discussion: Inflammatory markers improved throughout the intervention in the MASLD subjects and managed to reach similar levels to controls, especially at 6 and 12 months. Additionally, leptin, adiponectin, M30, and LECT2 managed to significantly diagnose the disease at all time marks of the intervention, making them candidates for subrogate non-invasive markers of the disease. Moreover, baseline chemerin, leptin, LECT2, and M65 were used to build a predictive score to achieve greater weight loss, and therefore, which strategy could be more useful for MASLD 's treatment. The predictive score was significantly able assign a specific diet to 55% of the study participants, meaning that the remaining 45% could achieve the same amount of weight loss following either diet equally. Conclusion: Inflammatory markers constitute a potential non-invasive tool to be used in MASLD screening and could also constitute an interesting tool for MASLD's treatment customization, being able to predict the effectiveness of a dietary strategy based on the initial inflammatory state of each subject. Trial registration: www.clinicaltrials.gov (NCT03183193). (c) 2024 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). C1 [Mogna-Pelaez, Paola; Riezu-Boj, Jose I.; Milagro, Fermin I.; Tobaruela-Resola, Ana Luz; Abete, Itziar; Zulet, M. Angeles] Univ Navarra, Fac Pharm & Nutr, Dept Nutr Food Sci & Physiol, Pamplona, Spain. [Mogna-Pelaez, Paola; Riezu-Boj, Jose I.; Milagro, Fermin I.; Tobaruela-Resola, Ana Luz; Abete, Itziar; Zulet, M. Angeles] Univ Navarra, Fac Pharm & Nutr, Ctr Nutr Res, Pamplona 31008, Spain. [Mogna-Pelaez, Paola; Riezu-Boj, Jose I.; Milagro, Fermin I.; Herrero, Jose I.; Elorz, Mariana; Benito-Boillos, Alberto; Abete, Itziar; Zulet, M. Angeles] Navarra Inst Hlth Res, IdiSNA, Pamplona 31008, Spain. [Milagro, Fermin I.; Tur, Josep A.; Martinez, J. Alfredo; Abete, Itziar; Zulet, M. Angeles] Biomed Res Ctr Network Physiopathol Obes & Nutr CI, Inst Salud Carlos3, CIBERobn, Madrid 28029, Spain. [Herrero, Jose I.] Clin Univ Navarra, Liver Unit, Pamplona 31008, Spain. [Herrero, Jose I.] Biomed Res Network Ctr Hepat & Digest Dis CIBERehd, Madrid 28029, Spain. [Elorz, Mariana; Benito-Boillos, Alberto] Clin Univ Navarra, Dept Radiol, Pamplona 31008, Spain. [Tur, Josep A.] Univ Balear Isl, Res Grp Community Nutr & Oxidat Stress, IUNICS, Palma De Mallorca 07122, Spain. [Tur, Josep A.] IDISBA, Palma De Mallorca 07122, Spain. [Martinez, J. Alfredo] CEI UAM CSIC, Precis Nutr & Cardiovasc Hlth Program, IMDEA Food, Madrid 28049, Spain. C3 University of Navarra; University of Navarra; University of Navarra; CIBER - Centro de Investigacion Biomedica en Red; CIBEROBN; University of Navarra; University of Navarra; Universitat de les Illes Balears; IUNICS; Institut Investigacio Sanitaria Illes Balears (IdISBa); Consejo Superior de Investigaciones Cientificas (CSIC); IMDEA Food Institute RP Zulet, MA (通讯作者)，Univ Navarra, Fac Pharm & Nutr, Dept Nutr Food Sci & Physiol, Pamplona, Spain.; Zulet, MA (通讯作者)，Univ Navarra, Fac Pharm & Nutr, Ctr Nutr Res, Pamplona 31008, Spain. EM mazulet@unav.es RI ; Tobaruela Resola, Ana Luz/MIO-9814-2025; Tur, Josep/AAE-5748-2020; Benito, Alberto/AAD-4201-2020; Milagro, Fermin/F-2315-2015; Carlón, Mariana/ABD-5128-2021; Riezu-Boj, Jose/M-3748-2014; Martínez, J./K-8709-2014; Zulet, M./H-1317-2017 OI Mogna-Peláez, Paola/0000-0001-6058-312X; Tobaruela Resola, Ana Luz/0009-0008-4484-8819; FU Health Department of the Government of Navarra [61/2015, PC082-083-084]; CIBERobn (Physiology of Obesity and Nutrition) [CB12/03/30002, CB12/03/30038]; Fundacio la Marato de TV3 [201630.10]; Centre for Nutrition Research (CIN) of the University of Navarra; FPU grant (Formacion de Profesorado Universitario) from the Spanish Ministry of Science and Innovation [FPU22/01560] FX The FLiO Study was financed by the Health Department of the Government of Navarra (Ref. 61/2015 and PC082-083-084) . This research was also supported by CIBERobn (Physiology of Obesity and Nutrition, CB12/03/30002 and CB12/03/30038) , Fundacio la Marato de TV3 (201630.10) , and the Centre for Nutrition Research (CIN) of the University of Navarra. This research was supported by an FPU grant (Formacion de Profesorado Universitario) from the Spanish Ministry of Science and Innovation to Paola Mogna-Pelaez (FPU22/01560) . Funding sources were not involved in the procedures of this study. 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Nutr. PD JUL PY 2024 VL 43 IS 7 BP 1770 EP 1781 DI 10.1016/j.clnu.2024.05.042 EA JUN 2024 PG 12 WC Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Nutrition & Dietetics GA WB4O8 UT WOS:001252397700001 PM 38861890 OA Green Submitted, hybrid DA 2026-02-02 ER PT J AU Bernardino, M Tiribelli, C Rosso, N AF Bernardino, Melvin Tiribelli, Claudio Rosso, Natalia TI The Impact of the Mediterranean Diet, Physical Activity, and Nutrition Education on Pediatric Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD): A Review SO NUTRIENTS LA English DT Review DE pediatric MASLD; Mediterranean diet; nutrition education; physical activity; nutrition ID CARDIOVASCULAR-DISEASE; CHILDREN; FAMILY; NAFLD; INVOLVEMENT; ADHERENCE; INTERVENTION; OBESITY; RISK AB Background/Objectives: Metabolic dysfunction-associated steatotic liver disease (MASLD) is now the most prevalent chronic liver disorder among children and adolescents, mirroring the rise in pediatric obesity. The Mediterranean diet (MD) has demonstrated anti-inflammatory, antioxidant, and beneficial effects on different health outcomes across different life stages. The MD's effect has been explored in adult MASLD, but there is limited information on the pediatric population. However, evidence on pediatric MASLD should be explored given its rising prevalence. Therefore, the aim of this review is to collect human studies assessing the effect of MD interventions on pediatric MASLD, focusing on key pathophysiological mechanisms. It also examines other interventions, including specific energy/macronutrient prescriptions, nutrition education or counseling, and physical activity components. Methods: A comprehensive search of PubMed, Scopus, and Web of Science was conducted using terms related to the Mediterranean diet, nutrition education, physical activity, pediatrics, and MASLD/NAFLD. Pre-determined inclusion and exclusion criteria were used to collect eligible studies to be included in the review. Study quality was assessed using the Academy of Nutrition and Dietetics Quality Criteria Checklist. Screening, data extraction, and appraisal were performed independently, with discrepancies resolved through discussion, and the findings were synthesized qualitatively. Results: This review synthesizes findings from eight human studies evaluating the impact of the MD, alone or integrated with structured exercise and nutrition education, on pediatric MASLD. Interventions consistently demonstrated reductions in hepatic steatosis, liver stiffness, and fibrosis markers, alongside improvements in inflammatory cytokines, oxidative stress defenses, and liver enzymes. The MD also enhanced lipid and glycemic profiles, lowering triglycerides, total cholesterol, and insulin resistance indices. Nutrition education and family-centered approaches improved adherence, while structured, enjoyable physical activity enhanced outcomes and long-term sustainability. Conclusions: Collectively, the MD, particularly when combined with exercise and tailored education, offers a safe, effective, and comprehensive lifestyle intervention for pediatric MASLD. Nonetheless, current evidence remains limited by small sample sizes, heterogeneity in protocols, and short follow-ups. Larger, multicenter randomized trials with standardized designs are needed to establish best practices and long-term efficacy. C1 [Bernardino, Melvin; Tiribelli, Claudio; Rosso, Natalia] Fdn Italiana Fegato, MASLD Unit, I-34149 Trieste, Italy. [Bernardino, Melvin] Univ Trieste, Dept Life Sci, I-34100 Trieste, Italy. [Bernardino, Melvin] Philippine Council Hlth Res & Dev, Dept Sci & Technol, Taguig 1631, Philippines. C3 University of Trieste; Department of Science & Technology (DOST), Philippines RP Bernardino, M; Rosso, N (通讯作者)，Fdn Italiana Fegato, MASLD Unit, I-34149 Trieste, Italy.; Bernardino, M (通讯作者)，Univ Trieste, Dept Life Sci, I-34100 Trieste, Italy.; Bernardino, M (通讯作者)，Philippine Council Hlth Res & Dev, Dept Sci & Technol, Taguig 1631, Philippines. EM melvin.bernardino@fegato.it; ctliver@fegato.it; natalia.rosso@fegato.it RI Rosso, Natalia/K-9035-2016 FU O-liver Project; DOST-PCHRD (Department of Science and Technology-Philippine Council for Health Research and Development) FX MB's scholarship is funded by the DOST-PCHRD (Department of Science and Technology-Philippine Council for Health Research and Development) 2023-2026. This study was funded by the O-liver Project (2024-2025) at Fondazione Italiana Fegato, Trieste, Italy. 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Nutrition & Dietetics GA AV3ET UT WOS:001657622400001 PM 41515146 OA Green Submitted, gold DA 2026-02-02 ER PT J AU López-González, AA Rifá, EMA Oliveira, HP Sánchez, CM López, PJT Ramírez-Manent, JI AF Lopez-Gonzalez, angel Arturo Rifa, Emilio Martinez-Almoyna Oliveira, Hernan Paublini Sanchez, Cristina Martorell Lopez, Pedro Juan Tarraga Ramirez-Manent, Jose Ignacio TI Association Between Sociodemographic Variables, Healthy Habits, and Stress with Risk Scales for Liver Disease Associated with Metabolic Dysfunction SO LIFE-BASEL LA English DT Article DE metabolic dysfunction-associated fatty liver disease (MAFLD); nonalcoholic steatohepatitis (NASH); sociodemographic variables; Mediterranean diet; physical activity; stress ID NAFLD; DIET AB Metabolic dysfunction-associated fatty liver disease (MAFLD) is the most common cause of chronic liver disease worldwide, with a multifactorial etiology. This study aims to evaluate the associations between various sociodemographic variables, healthy habits, and stress with risk scale values for MAFLD. Materials and Methods: A descriptive, cross-sectional study was conducted on 16,708 Spanish workers to assess how sociodemographic variables (age, gender, and socioeconomic status), healthy habits (smoking, Mediterranean diet adherence, and physical activity), and stress correlate with values from three MAFLD risk scales: fatty liver index (FLI), hepatic steatosis index (HSI), and lipid accumulation product (LAP). Results: All analyzed variables were associated with the values of the three MAFLD risk scales. Among them, the variables showing the strongest associations (represented by odds ratio values) were age and physical activity. Conclusions: The profile of an individual at higher risk of elevated MAFLD risk scale values is a male, aged 50 or older, belonging to lower socioeconomic levels (manual laborers), a smoker, sedentary, with low adherence to the Mediterranean diet, and with high stress scale scores. C1 [Lopez-Gonzalez, angel Arturo; Rifa, Emilio Martinez-Almoyna; Oliveira, Hernan Paublini; Sanchez, Cristina Martorell; Ramirez-Manent, Jose Ignacio] Univ Inst Hlth Sci IUN Balear Isl, ADEMA Hlth Grp, Palma De Mallorca 07122, Spain. [Lopez-Gonzalez, angel Arturo; Rifa, Emilio Martinez-Almoyna; Oliveira, Hernan Paublini; Sanchez, Cristina Martorell] Univ Sch ADEMA UIB, Fac Odontol, Palma De Mallorca 07009, Spain. [Lopez-Gonzalez, angel Arturo; Ramirez-Manent, Jose Ignacio] Balear Isl Hlth Serv, Palma De Mallorca, Spain. [Lopez, Pedro Juan Tarraga] Castilla La Mancha Univ, Fac Med, Albacete 02071, Spain. [Ramirez-Manent, Jose Ignacio] Univ Balear Isl, Palma De Mallorca, Spain. C3 Universitat de les Illes Balears RP López, PJT (通讯作者)，Castilla La Mancha Univ, Fac Med, Albacete 02071, Spain. EM angarturo@gmail.com; emilio@udemax.com; h.paublini@eue.edu.es; c.martorell@eua.edu.es; pjtarraga@sescam.jccm.es; joseignacio.ramirez@ibsalut.es RI ; Lopez Gonzalez, Angel Arturo/AAN-2248-2021 OI Tarraga López, Peo Juan/0000-0002-5222-5784; Lopez Gonzalez, Angel Arturo/0000-0002-7439-8117; Ramírez Manent, José Ignacio/0000-0001-6887-4562 CR Abdelhameed F, 2024, CURR OBES REP, V13, P510, DOI 10.1007/s13679-024-00574-z Ajmera V, 2020, MOL METAB, V50, DOI 10.1016/j.molmet.2021.101167 Aller R, 2020, ENDOCRINE, V68, P557, DOI 10.1007/s12020-020-02268-7 Alqahtani SA, 2021, CLIN INTERV AGING, V16, P1633, DOI 10.2147/CIA.S295524 Alzamora TS, 2023, MED BALEAR, V38, DOI 10.3306/AJHS.2023.38.06.66 Alzamora TS, 2023, MED BALEAR, V38, DOI 10.3306/AJHS.2023.38.06.137 Balogun O, 2023, HEPATOL COMMUN, V7, DOI 10.1097/HC9.0000000000000300 Braillon A, 2021, AM J GASTROENTEROL, V116, P617, DOI 10.14309/ajg.0000000000001131 Cho J, 2021, INT J ENV RES PUB HE, V18, DOI 10.3390/ijerph18041892 Devarbhavi H, 2023, J HEPATOL, V79, P516, DOI 10.1016/j.jhep.2023.03.017 DiStefano JK, 2020, ENDOCRINOLOGY, V161, DOI 10.1210/endocr/bqaa134 Gao Y, 2020, REDOX BIOL, V36, DOI 10.1016/j.redox.2020.101635 Haigh L, 2022, CLIN NUTR, V41, P1913, DOI 10.1016/j.clnu.2022.06.037 He YY, 2023, AGEING RES REV, V84, DOI 10.1016/j.arr.2022.101833 Huang DIQ, 2021, NAT REV GASTRO HEPAT, V18, P223, DOI 10.1038/s41575-020-00381-6 Hutchison AL, 2023, J HEPATOL, V79, P1524, DOI 10.1016/j.jhep.2023.08.030 Kang D, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-019-57036-z Kim D, 2022, CLIN GASTROENTEROL H, V20, pE1438, DOI 10.1016/j.cgh.2021.06.029 Kim M, 2023, FRONT PUBLIC HEALTH, V11, DOI 10.3389/fpubh.2023.1281530 Liu EQ, 2024, NICOTINE TOB RES, V26, P663, DOI 10.1093/ntr/ntad249 Machado MV, 2023, NAT REV GASTRO HEPAT, V20, P67, DOI 10.1038/s41575-022-00717-4 Martinez-Almoyna Rifa E, 2023, Acad J Health Sci, V38, P92, DOI DOI 10.3306/AJHS.2023.38.04.92 Rifá EMA, 2023, MED BALEAR, V38, P138, DOI 10.3306/AJHS.2023.38.05.138 Martnez-Almoyna Rif E., 2023, Acad. 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Despite higher incidence, effective treatment options for this population are controversial. This Meta-analysis aims to evaluate the effects of all non-invasive treatment modalities available for MASLD. Methods: This study includes PubMed, Cochrane Library, and Embase searches (January 2010 to July 2025) for Randomised Controlled Trials (RCTs), evaluating different treatment modalities of MASLD in pediatrics and adolescent population. Risk of bias was assessed using the Cochrane Risk of Bias 2 tool. Primary outcomes were Aspartate Aminotransferase (AST), Triglycerides (TGs) and Low-Density Lipoproteins (LDL). Secondary outcomes were Alanine Aminotransferase (ALT), Gamma-Glutamyl Transferase (GGT), High-Density Lipoprotein (HDL) and adverse effects. Data were analyzed using Revman 5.3. Continuous values were pooled using the standard mean difference (SMD). Sensitivity analysis was performed to reduce heterogeneity. This study was registered with PROSPERO, CRD42024596682. Results: We included 31 RCTs, having 1722 participants. Multiple treatment modalities were identified and categorized into dietary intervention, supplementation, drug intervention and exercise. We further categorized dietary intervention into low-sugar diet, low-fat diet and mediterranean diet and compared against different controls. The low-sugar diet showed significant improvement in TG levels against placebo/usual diet [-2.44,95 % CI:3.61,-1.27] and in AST levels against low-fat diet [-1.02, 95 %CI-1.88,-0.16]. LDL levels showed significant change when probiotics were administered against placebo [-0.33, 95 % CI:0.65,0.00]. Conclusion: Supplements and Dietary intervention have shown improvement in liver enzymes and lipid profile. However, more research is required to evaluate the dosage and adverse effects associated with these interventions. C1 [Zaidi, Syed Muhammad Mehdi; Irfan, Qunoot; Javed, Rahmah; Khalid, Zulekha; Khan, Hamna; Ashraf, Muhammad Hasan] Dow Univ Hlth Sci, Karachi, Pakistan. [Alvi, Mustafa Hassan; Zehra, Sana] Univ Nevada, Reno, NV USA. [Wahid, Faiq; Abbas, Zainab] Jinnah Sindh Med Univ, Karachi, Pakistan. C3 Dow University of Health Sciences; Nevada System of Higher Education (NSHE); University of Nevada Reno; Jinnah Sindh Medical University - Pakistan RP Zaidi, SMM (通讯作者)，Dow Univ Hlth Sci, Karachi, Pakistan. 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Beigrezaei, Sara CA GRIPonMASH Consortium TI Effects of Mediterranean diet, exercise, and their combination on body composition and liver outcomes in metabolic dysfunction-associated steatotic liver disease: a systematic review and meta-analysis of randomized controlled trials SO BMC MEDICINE LA English DT Review DE Lifestyle; Metabolic dysfunction-associated steatotic liver disease; Non-alcoholic fatty liver disease; Metabolic dysfunction-associated steatohepatitis; Mediterranean diet; Exercise; Systematic review; Meta-analysis ID LIFE-STYLE MODIFICATION; INTERVAL TRAINING HIT; FATTY-LIVER; CLINICAL CHARACTERISTICS; INSULIN SENSITIVITY; RESISTANCE EXERCISE; VISCERAL ADIPOSITY; HEPATIC STEATOSIS; PHYSICAL-ACTIVITY; PRACTICE GUIDANCE AB BackgroundMetabolic dysfunction-associated steatotic liver disease (MASLD) is a leading cause of liver-related morbidity and mortality. Lifestyle interventions like the Mediterranean diet (MD) and exercise are recommended for management, but the most effective lifestyle approach remains unclear.MethodsA comprehensive literature search was conducted in Embase, MEDLINE via Ovid, Cochrane Central, and Web of Science Core Collection from inception to April 1, 2025, without language restrictions. We included randomized controlled trials (RCTs) in adults with MASLD or metabolic dysfunction-associated steatohepatitis (MASH) assessing the MD and/or exercise interventions on anthropometric measures, liver enzymes, and indices or grades of liver steatosis and fibrosis. The mean difference and corresponding 95% confidence interval (CI) were pooled using a random-effects model. Risk of bias was assessed with ROB-2, and evidence certainty was evaluated using GRADE.ResultsFrom a total of 4806 search results, 37 unique RCTs met the inclusion criteria, from which 11 assessed the MD and 27 exercise, either aerobic, resistance, or in combination, and two RCTs assessed the effect of the MD and exercise combination. Meta-analyses showed that the MD in comparison with the control significantly reduced body weight [weighted mean difference (WMD = - 2.38 kg, 95% CI - 4.11 to - 0.66), body mass index (WMD = - 0.70 kg/m2, 95% CI = - 1.03 to - 0.36), waist circumference (WC) (WMD = - 1.56 cm, 95% CI - 3.02 to - 0.09), and alanine aminotransferase (ALT) (WMD = - 3.96 IU/L, 95% CI - 6.54 to - 1.38). Aerobic and combined aerobic-resistance exercises in comparison with the control group reduced body weight (WMD = - 1.56 kg, 95%CI - 2.31 to - 0.82; WMD = - 1.90 kg, 95%CI - 3.59 to - 0.22, respectively). In addition, aerobic exercise significantly decreased WC (WMD = - 2.14 IU/L, 95%CI - 2.87 to - 1.41) and resistance exercise reduced ALT (WMD = - 15.40 IU/L, 95%CI - 28.60 to - 2.20) in patients with MASLD/MASH compared to the control group.ConclusionsThe MD and aerobic exercise, whether alone or combined with resistance training, support weight loss and improve liver health in patients with MASLD/MASH. Standardized methods for measuring and reporting outcomes are essential to build robust evidence on the impact of lifestyle changes on clinical outcomes.Trial registrationPROSPERO registration code. CRD42024577846.Trial registrationPROSPERO registration code. CRD42024577846. C1 [Arita, Vicente Artola; Vargas, Juliana Alexandra Hernandez; Trujillo-Caceres, Silvia Juliana; Pernicone, Nathalie Mendez; Bridge, Lara Anne; Raeisi-Dehkordi, Hamidreza; Dekker, Ruben; Uriza-Pinzon, Julieth Pilar; Grobbee, Diederick E.; Franco, Oscar H.; Beigrezaei, Sara] Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Dept Global Publ Hlth & Bioeth, Utrecht, Netherlands. [Cabezas, Manuel Castro; Dietvorst, Carmen A. W.] Franciscus Gasthuis & Vlietland, Dept Internal Med, Rotterdam, Netherlands. [Cabezas, Manuel Castro; Grobbee, Diederick E.] Julius Clin, Zeist, Netherlands. [Cabezas, Manuel Castro] Erasmus MC, Dept Internal Med, Dept Endocrinol, Rotterdam, Netherlands. [Dietvorst, Carmen A. W.; Berk, Kirsten A.] Erasmus MC, Dept Internal Med, Div Dietet, Rotterdam, Netherlands. [Tawfik, Mohamed] Novo Nordisk, Bagsvaerd, Denmark. [Massoels, Jo] Echosens, Paris, France. [Driessen, Stan; Holleboom, Adriaan G.] Univ Amsterdam, Dept Internal & Vasc Med, Med Ctr, Amsterdam, Netherlands. [Tushuizen, Maarten E.] Leiden Univ, Med Ctr, Dept Gastroenterol & Hepatol, Leiden, Netherlands. C3 Utrecht University; Utrecht University Medical Center; Franciscus Gasthuis; Erasmus University Rotterdam; Erasmus MC; Erasmus University Rotterdam; Erasmus MC; University of Amsterdam; Leiden University; Leiden University Medical Center (LUMC); Leiden University - Excl LUMC RP Beigrezaei, S (通讯作者)，Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Dept Global Publ Hlth & Bioeth, Utrecht, Netherlands. EM S.Beigrezaei@umcutrecht.nl RI ; Driessen, Stan/OLQ-8232-2025; Beigrezaei, Sara/AAZ-6682-2020 OI Berk, Kirsten/0000-0003-4097-4785; iessen, Stan/0000-0003-1485-9732; FU Innovative Health Initiative Joint Undertaking FX Not applicable. 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PD AUG 27 PY 2025 VL 23 IS 1 AR 502 DI 10.1186/s12916-025-04320-7 PG 20 WC Medicine, General & Internal WE Science Citation Index Expanded (SCI-EXPANDED) SC General & Internal Medicine GA 6RU9R UT WOS:001560496800004 PM 40866968 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Baselga-Escudero, L Souza-Mello, V Pascual-Serrano, A Rachid, T Voci, A Demori, I Grasselli, E AF Baselga-Escudero, Laura Souza-Mello, Vanessa Pascual-Serrano, Aida Rachid, Tamiris Voci, Adriana Demori, Ilaria Grasselli, Elena TI Beneficial effects of the Mediterranean spices and aromas on non-alcoholic fatty liver disease SO TRENDS IN FOOD SCIENCE & TECHNOLOGY LA English DT Review DE Non-alcoholic fatty liver disease (NAFLD); Mediterranean plants and spices (MAPS); Polyphenols; Anti-steatotic compounds; Peroxisome proliferator activated receptors (PPARs); Non-pharmacological therapy ID PARSLEY PETROSELINUM-CRISPUM; CORONARY-HEART-DISEASE; DIET-INDUCED OBESITY; L. LEAF EXTRACT; RANDOMIZED CONTROLLED-TRIAL; ACTIVATED RECEPTOR-ALPHA; LIFE-STYLE INTERVENTIONS; DE-NOVO LIPOGENESIS; CUMINUM-CYMINUM L.; LIMITS WEIGHT-GAIN AB Background: Non-alcoholic fatty liver disease (NAFLD) can be regarded as the hepatic manifestation of metabolic syndrome (MS), which has a high prevalence in Western-lifestyle countries. NAFLD can progress to more severe pathologies such as cirrhosis and fibrosis, thus worsening individuals' life quality and increasing health costs. In the last decades, many efforts have been made in order to understand the molecular mechanisms of NAFLD and how to cure it. It has become clear that alimentary regimen is of primary importance for preventing/treating MS and NAFLD. Scope and approach: Beneficial effects of the Mediterranean diet (MedDiet) on MS and NAFLD are now recognized and can be ascribed to low calories intake but also to abundance of anti-oxidant and antiinflammatory compounds which are present in fruit and vegetables as well as in herbs and spices widely used to flavor traditional Mediterranean dishes. The aim of this review is to summarize briefly NAFLD molecular pathways and therapies, while focusing on the beneficial effects and mechanisms of action of the most used Mediterranean aromatic plants and spices (MAPS). Key findings and conclusions: All MAPS reviewed here have been documented to exert hepatoprotective actions and almost the totality has a direct or indirect lipid-lowering effect on the liver, accompanied by amelioration of other MS parameters. We suggest that culinary MAPS use can contribute to the health benefits of MedDiet without the danger of adverse effects that can occur when the active compounds are used in pharmacological doses. (C) 2017 Elsevier Ltd. All rights reserved. C1 [Baselga-Escudero, Laura] EURECAT CTNS, GRNS, Reus, Spain. [Souza-Mello, Vanessa; Rachid, Tamiris] State Univ Rio de Janeiro Brazil, Inst Biol, Biomed Ctr, Lab Morphometry Metab & Cardiovasc Dis, Rio De Janeiro, RJ, Brazil. [Pascual-Serrano, Aida] Univ Rovira & Virgili, Dept Biochem & Biotechnol, Nutrigen Res Grp, Tarragona, Spain. [Voci, Adriana; Demori, Ilaria; Grasselli, Elena] Univ Genoa, DISTAV, Dipartimento Sci Terra Ambiente & Vita, Corso Europa 26, I-16132 Genoa, Italy. [Grasselli, Elena] Ist Nazl Biostrutture & Biosistemi, Rome, Italy. C3 Universitat Rovira i Virgili; University of Genoa RP Grasselli, E (通讯作者)，Univ Genoa, DISTAV, Dipartimento Sci Terra Ambiente & Vita, Corso Europa 26, I-16132 Genoa, Italy. 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TI Diet and Lifestyle Interventions in Metabolic Dysfunction-Associated Fatty Liver Disease: A Comprehensive Review SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES LA English DT Review DE metabolic dysfunction-associated steatotic liver disease (MASLD); metabolic dysfunction-associated steatohepatitis (MASH); macronutrients; micronutrients; lifestyle intervention; weight loss; obesity; dietary modifications; aerobic exercise; resistance exercise ID IMPROVES INSULIN-RESISTANCE; STOP HYPERTENSION DASH; GINKGO-BILOBA EXTRACT; LOW-CARBOHYDRATE DIET; HEPATIC STEATOSIS; WEIGHT-LOSS; NONALCOHOLIC STEATOHEPATITIS; PHYSICAL-ACTIVITY; MEDITERRANEAN DIET; DOUBLE-BLIND AB Metabolic dysfunction-associated steatotic liver disease (MASLD) and its progressive form, metabolic dysfunction-associated steatohepatitis (MASH), have become the leading causes of chronic liver disease worldwide, with increasing rates of cirrhosis, hepatocellular carcinoma, and cardiovascular complications. Pathogenesis involves a complex interplay of dietary excess, sedentary lifestyle, insulin resistance, adipose tissue dysfunction, and alterations in the gut microbiome, which collectively lead to hepatocellular stress, inflammation, and fibrogenesis. Despite ongoing advances in pharmacotherapy, lifestyle intervention remains the cornerstone of management. Evidence shows that sustained weight loss of >= 5% reduces hepatic steatosis, >= 7% improves necroinflammation, and >= 10% stabilizes or reverses fibrosis. Dietary strategies, including Mediterranean-style patterns, high-protein approaches, and intermittent fasting, have been shown to be effective in improving insulin sensitivity and reducing intrahepatic triglycerides. Exercise interventions, focusing on both aerobic fitness and resistance training, enhance metabolic flexibility and combat sarcopenia, thereby improving hepatic and systemic outcomes. Equally important are behavioral support, digital health tools, and multidisciplinary approaches that enhance adherence and address barriers such as socioeconomic disparities, limited access, and patient engagement issues. Personalized nutrition plans, integrating physical activity, and ongoing support for behavioral change are essential for long-term disease management. This review synthesizes current evidence on the roles of macronutrients, micronutrients, dietary quality, physical activity, and adjunctive behavioral strategies in managing MASLD. By translating mechanistic insights into practical, evidence-based recommendations, we aim to provide clinicians, dietitians, and exercise professionals with effective frameworks to slow disease progression and improve outcomes across diverse patient populations. C1 [Sheikh, Muhammad Y.; Younus, Muhammad F.; Shergill, Annie; Hasan, Muhammad N.] Fresno Clin Res Ctr, Fresno, CA 93720 USA. RP Sheikh, MY (通讯作者)，Fresno Clin Res Ctr, Fresno, CA 93720 USA. 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J. Mol. Sci. PD OCT 2 PY 2025 VL 26 IS 19 AR 9625 DI 10.3390/ijms26199625 PG 59 WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary WE Science Citation Index Expanded (SCI-EXPANDED) SC Biochemistry & Molecular Biology; Chemistry GA 8OQ7Y UT WOS:001593660200001 PM 41096891 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Tsitsou, S Bali, T Adamantou, M Saridaki, A Poulia, KA Karagiannakis, DS Papakonstantinou, E Cholongitas, E AF Tsitsou, Sofia Bali, Triada Adamantou, Magdalini Saridaki, Aristi Poulia, Kalliopi-Anna Karagiannakis, Dimitrios S. Papakonstantinou, Emilia Cholongitas, Evangelos TI Effects of a 12-Week Mediterranean-Type Time-Restricted Feeding Protocol in Patients With Metabolic Dysfunction-Associated Steatotic Liver Disease: A Randomised Controlled Trial-The 'CHRONO-NAFLD Project' SO ALIMENTARY PHARMACOLOGY & THERAPEUTICS LA English DT Article DE glucose metabolism; insulin resistance; intermittent fasting; liver steatosis; Mediterranean diet; metabolic dysfunction-associated steatotic liver disease; time-restricted feeding ID INSULIN SENSITIVITY; CALORIE RESTRICTION; CHOLESTEROL; GLUCOSE; RESISTANCE; PLASMA; INDEX; RATIO; RISK AB Background: The Mediterranean diet (MD) is considered the best dietary approach for patients with metabolic dysfunction-associated steatotic liver disease (MASLD). Recently, time-restricted feeding (TRF) has gained attention for its lifestyle compatibility and health benefits. Aims: This study aimed to compare the effects of a hypocaloric MD with a 10-h TRF protocol to an unrestricted MD in MASLD patients with overweight/obesity and evaluate differences between early and late TRF. Methods: This 12-week randomised controlled trial in MASLD patients with overweight/obesity consisted of three groups, all following a hypocaloric Mediterranean-type diet. The control group had no eating time restrictions. The early TRF (eTRF) and late TRF (lTRF) groups had a 10-h eating window, from 8 AM to 6 PM and from 12 PM to 10 PM, respectively. Various health parameters were measured. Compliance was tracked via food diaries, and an 8-week follow-up occurred post-intervention. ResultsFifty-nine MASLD individuals (27 males; 52.9 years; body mass index 32.1 kg/m2) completed the trial (control, n = 19; eTRF, n = 20; lTRF, n = 20). All groups showed significant 12-week reductions in body weight, anthropometry and blood pressure. Glycated haemoglobin A1c and insulin resistance, as measured by the Matsuda index, homeostatic model assessment for insulin resistance and fasting glucose-to-insulin ratio, improved in the eTRF group at 12 weeks. Conclusions: This study corroborates the efficacy of MD in ameliorating cardiometabolic risk factors such as body weight and blood pressure in MASLD patients. The combination with an eTRF protocol may improve glycaemic control (NCT05866744). Trial RegistrationThe study is registered at (NCT05866744) C1 [Tsitsou, Sofia; Poulia, Kalliopi-Anna; Papakonstantinou, Emilia] Agr Univ Athens, Dept Food Sci & Human Nutr, Lab Dietet & Qual Life, Athens, Greece. [Bali, Triada; Adamantou, Magdalini; Saridaki, Aristi; Cholongitas, Evangelos] Natl & Kapodistrian Univ Athens, Laiko Gen Hosp Athens, Med Sch, Dept Internal Med 1, Athens, Greece. [Karagiannakis, Dimitrios S.] Natl & Kapodistrian Univ Athens, Attiko Univ Hosp, Med Sch, Dept Internal Med 4, Athens, Greece. C3 Agricultural University of Athens; Laiko General Hospital; National & Kapodistrian University of Athens; National & Kapodistrian University of Athens; University Hospital Attikon RP Papakonstantinou, E (通讯作者)，Agr Univ Athens, Dept Food Sci & Human Nutr, Lab Dietet & Qual Life, Athens, Greece.; Cholongitas, E (通讯作者)，Natl & Kapodistrian Univ Athens, Laiko Gen Hosp Athens, Med Sch, Dept Internal Med 1, Athens, Greece. 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PD APR PY 2025 VL 61 IS 8 BP 1290 EP 1309 DI 10.1111/apt.70044 EA FEB 2025 PG 20 WC Gastroenterology & Hepatology; Pharmacology & Pharmacy WE Science Citation Index Expanded (SCI-EXPANDED) SC Gastroenterology & Hepatology; Pharmacology & Pharmacy GA 1CF4D UT WOS:001434368700001 PM 40017349 OA Green Submitted, hybrid HC Y HP N DA 2026-02-02 ER PT J AU Termite, F Archilei, S D'Ambrosio, F Petrucci, L Viceconti, N Iaccarino, R Liguori, A Gasbarrini, A Miele, L AF Termite, Fabrizio Archilei, Sebastiano D'Ambrosio, Francesca Petrucci, Lucrezia Viceconti, Nicholas Iaccarino, Roberta Liguori, Antonio Gasbarrini, Antonio Miele, Luca TI Gut Microbiota at the Crossroad of Hepatic Oxidative Stress and MASLD SO ANTIOXIDANTS LA English DT Review DE metabolic dysfunction-associated steatotic liver disease; gut microbiota; oxidative stress; lipid peroxidation; intestinal permeability; farnesoid X receptor; ferroptosis; trimethylamine N-oxide; platelet activation ID FATTY LIVER-DISEASE; TOLL-LIKE RECEPTOR-4; INTESTINAL BARRIER; BILE-ACIDS; PARTICULATE MATTER; PERMEABILITY TRANSITION; RESISTANCE EXERCISE; ALCOHOLIC HEPATITIS; MEDITERRANEAN DIET; INSULIN-RESISTANCE AB Metabolic dysfunction-associated steatotic liver disease (MASLD) is a prevalent chronic liver condition marked by excessive lipid accumulation in hepatic tissue. This disorder can lead to a range of pathological outcomes, including metabolic dysfunction-associated steatohepatitis (MASH) and cirrhosis. Despite extensive research, the molecular mechanisms driving MASLD initiation and progression remain incompletely understood. Oxidative stress and lipid peroxidation are pivotal in the "multiple parallel hit model", contributing to hepatic cell death and tissue damage. Gut microbiota plays a substantial role in modulating hepatic oxidative stress through multiple pathways: impairing the intestinal barrier, which results in bacterial translocation and chronic hepatic inflammation; modifying bile acid structure, which impacts signaling cascades involved in lipidic metabolism; influencing hepatocytes' ferroptosis, a form of programmed cell death; regulating trimethylamine N-oxide (TMAO) metabolism; and activating platelet function, both recently identified as pathogenetic factors in MASH progression. Moreover, various exogenous factors impact gut microbiota and its involvement in MASLD-related oxidative stress, such as air pollution, physical activity, cigarette smoke, alcohol, and dietary patterns. This manuscript aims to provide a state-of-the-art overview focused on the intricate interplay between gut microbiota, lipid peroxidation, and MASLD pathogenesis, offering insights into potential strategies to prevent disease progression and its associated complications. C1 [Termite, Fabrizio; Archilei, Sebastiano; D'Ambrosio, Francesca; Petrucci, Lucrezia; Viceconti, Nicholas; Iaccarino, Roberta; Liguori, Antonio; Gasbarrini, Antonio; Miele, Luca] Univ Cattolica Sacro Cuore, Fdn Policlin Univ A Gemelli IRCCS, CEMAD Digest Dis Ctr, Largo A Gemelli 8, I-00168 Rome, Italy. C3 Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli RP Miele, L (通讯作者)，Univ Cattolica Sacro Cuore, Fdn Policlin Univ A Gemelli IRCCS, CEMAD Digest Dis Ctr, Largo A Gemelli 8, I-00168 Rome, Italy. 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Metabolic age, determined through bioimpedance analysis, has emerged as a potential indicator of overall metabolic health. The objective of this study is to evaluate the association between metabolic age and MASLD risk scores in a cohort of Spanish workers. Methods: A cross-sectional study was conducted on 8590 Spanish workers who underwent annual occupational health examinations between 2019 and 2020. Metabolic age was determined using bioelectrical impedance analysis, and the Avoidable Lost Life Years (ALLY) index was calculated as the difference between their metabolic and chronological age. MASLD risk was assessed using various validated scales, including the Fatty Liver Index (FLI), Hepatic Steatosis Index (HSI), Zhejiang University Index (ZJU), Fatty Liver Disease Index (FLD), and Lipid Accumulation Product (LAP). A multinomial logistic regression analysis was performed to examine the association between metabolic age and MASLD risk scores, adjusting for sociodemographic and lifestyle variables. Results: Higher metabolic age values were observed in individuals with greater MASLD risk across all evaluated scales. The mean metabolic age was consistently lower in women compared to men, and these differences were statistically significant (p < 0.01). Multinomial logistic regression analysis revealed that the strongest associations with increased metabolic age were found for MASLD risk scores, physical inactivity, and poor adherence to the Mediterranean diet. ROC curve analysis demonstrated a high predictive capacity for the FLD (AUC: 0.935 in women and 0.917 in men) and FLI (AUC: 0.900 in women and 0.833 in men), with high Youden index values. Conclusions: Metabolic age is significantly associated with MASLD risk, suggesting its potential as a non-invasive biomarker for identifying individuals with a higher risk for metabolic liver disease. Lifestyle factors, including physical activity and dietary patterns, play a crucial role in modulating metabolic age, highlighting the importance of targeted interventions for MASLD prevention. Further research is warranted to validate metabolic age as a prognostic tool in MASLD risk assessment. C1 [Ramirez-Gallegos, Ignacio; Busquets-Cortes, Carla; Paublini, Hernan; Lopez-Gonzalez, angel Arturo; Martinez-Almoyna-Rifa, Emilio; Lopez, Pedro Juan Tarraga; Ramirez-Manent, Jose Ignacio] Univ Inst Hlth Sci Res IUN, Hlth Grp, ADEMA, Palma De Mallorca 07009, Balearic Isl, Spain. [Lopez-Gonzalez, angel Arturo] Univ Sch ADEMA, Fac Dent, Palma De Mallorca 07009, Balear Isl, Spain. [Lopez-Gonzalez, angel Arturo; Ramirez-Manent, Jose Ignacio] Balearic Isl Hlth Res Inst Fdn, Balearic Isl Inst Hlth Res IDISBA, Palma De Mallorca 07010, Balearic Isl, Spain. [Lopez-Gonzalez, angel Arturo; Ramirez-Manent, Jose Ignacio] Balearic Isl Hlth Serv, Palma De Mallorca 07010, Balearic Isl, Spain. [Lopez, Pedro Juan Tarraga] Univ Castilla La Mancha, Fac Med, Albacete 02008, Castilla La Man, Spain. [Ramirez-Manent, Jose Ignacio] Univ Balearic Isl, Fac Med, Palma De Mallorca 07010, Balearic Isl, Spain. C3 Universidad de Castilla-La Mancha; Universitat de les Illes Balears RP López-González, AA (通讯作者)，Univ Inst Hlth Sci Res IUN, Hlth Grp, ADEMA, Palma De Mallorca 07009, Balearic Isl, Spain.; López-González, AA (通讯作者)，Univ Sch ADEMA, Fac Dent, Palma De Mallorca 07009, Balear Isl, Spain.; López-González, AA (通讯作者)，Balearic Isl Hlth Res Inst Fdn, Balearic Isl Inst Hlth Res IDISBA, Palma De Mallorca 07010, Balearic Isl, Spain.; López-González, AA (通讯作者)，Balearic Isl Hlth Serv, Palma De Mallorca 07010, Balearic Isl, Spain. 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This study aimed to investigate the association between adherence to various dietary patterns and cardiovascular disease (CVD) mortality in a middle-aged Korean MASLD population.MethodsBaseline data from 32,091 adults aged 40 years and older enrolled in the Korean Genome and Epidemiology Study (KoGES) between 2004 and 2013 were analyzed. Dietary intake was assessed using a validated semi-quantitative food frequency questionnaire, and principal component analysis was applied to identify distinct dietary patterns. The primary outcome was CVD mortality, assessed using Cox proportional hazards models adjusted for confounders, including age, sex, body mass index, smoking status, alcohol intake, physical activity, total calorie intake, hypertension, diabetes, and dyslipidemia.ResultsAdherence to the Korean Mediterranean-style diet was associated with a significantly reduced risk of CVD mortality in MASLD patients, with those in the highest Korean Mediterranean-style diet pattern quartile having a 33% lower risk than those in the lowest quartile (hazards ratio: 0.67, 95% confidence interval: 0.45-1.00, p = 0.048). Other dietary patterns, including the processed food and dairy diet, animal protein-rich diet, grain-based diet, as well as refined carbohydrate and fat-rich diet, were not significantly associated with CVD mortality.ConclusionsAdherence to Korean Mediterranean-style diet pattern was associated with a lower risk of CVD mortality in Korean adults with MASLD, highlighting its potential as an effective dietary strategy for managing cardiovascular risk in MASLD patients, even in non-Western populations. C1 [Kwon, Yu-Jin] Yonsei Univ, Coll Med, Yongin Severance Hosp, Dept Family Med, Yongin, South Korea. [Lee, Hye Sun] Yonsei Univ, Coll Med, Dept Res Affairs, Biostat Collaborat Unit, Seoul, South Korea. [Lee, Ji-Won] Yonsei Univ, Coll Med, Severance Hosp, Dept Family Med, Seoul, South Korea. [Lee, Ji-Won] Yonsei Univ, Inst Innovat Digital Healthcare, Seoul, South Korea. C3 Yonsei University; Yonsei University Health System; Yonsei University; Yonsei University Health System; Yonsei University; Yonsei University Health System; Yonsei University RP Lee, HS (通讯作者)，Yonsei Univ, Coll Med, Dept Res Affairs, Biostat Collaborat Unit, Seoul, South Korea.; Lee, JW (通讯作者)，Yonsei Univ, Coll Med, Severance Hosp, Dept Family Med, Seoul, South Korea.; Lee, JW (通讯作者)，Yonsei Univ, Inst Innovat Digital Healthcare, Seoul, South Korea. EM hslee1@yuhs.ac; INDI5645@yuhs.ac RI ; Lee, Hye Sun/AAD-6757-2019; KWON, YUJIN/ACB-8082-2022 OI LEE, JI WON/0000-0002-2666-4249; Lee, Hye Sun/0000-0001-6328-6948; KWON, YUJIN/0000-0002-9021-3856 FU Korea Institute of Planning and Evaluation for Technology in Food, Agriculture, and Forestry (IPET) through a high-value-added food technology development program - Ministry of Agriculture, Food, and Rural Affairs (MAFRA) [321030051HD030]; National Research Foundation of Korea (NRF) grant from the Korean government (MSIT) [RS-2024-00354524] FX This study received funding from the Korea Institute of Planning and Evaluation for Technology in Food, Agriculture, and Forestry (IPET) through a high-value-added food technology development program supported by the Ministry of Agriculture, Food, and Rural Affairs (MAFRA) (321030051HD030). It was also funded by a National Research Foundation of Korea (NRF) grant from the Korean government (MSIT) (RS-2024-00354524). 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Alves, Lilian Babio, Nancy Fito, Montserrat Ros, Emilio Fiol, Miquel Estruch, Ramon Aros, Fernando Serra-Majem, Luis Pinto, Xavier Munoz-Bravo, Carlos Garcia-Rodriguez, Antonio Gomez-Gracia, Enrique TI Adherence to the Mediterranean diet to prevent or delay hepatic steatosis: a longitudinal analysis within the PREDIMED study SO FRONTIERS IN NUTRITION LA English DT Article DE PREDIMED; dietary adherence; Mediterranean diet; randomized controlled trial; metabolic dysfunction-associated steatotic liver disease; hepatic steatosis index ID FATTY LIVER-DISEASE; PHYSICAL-ACTIVITY QUESTIONNAIRE; LIFE-STYLE; METABOLIC SYNDROME; FOLLOW-UP; HEALTH; INDEX; INTERVENTION; ASSOCIATION; SEVERITY AB Background Little is known about the potential preventive effect of adherence to the Mediterranean diet (MedDiet) on the development of metabolic dysfunction-associated steatotic liver disease (MASLD).Aim This study aims to determine the impact of adherence to the MedDiet on the progression of MASLD, measured using the hepatic steatosis index (HSI) at baseline and annually over a 5-year follow-up period within the framework of the PREvenci & oacute;n con DIeta MEDiterr & aacute;nea (PREDIMED) study.Method Participants from the PREDIMED trial with sufficient available data (n = 3,145) were examined annually over 5 years. Adherence to the MedDiet was evaluated using the Mediterranean Diet Adherence Screener (MEDAS) questionnaire, and the presence/severity of hepatic steatosis was determined according to the HSI. Linear mixed models were used to analyze the association between the study variables and HSI.Results The participants (57% female, 43% male) had a mean age of 67.2 (SD 6.2) years. Among the cardiovascular risk factors considered, the mean BMI was 29.81 (SD 3.62); 47% of participants had type 2 diabetes, 70% had hypercholesterolaemia, and 84% had hypertension. Over the 5-year follow-up, average adherence to the MedDiet and physical activity generally increased, while alcohol consumption, calorie intake, tobacco use, hypercholesterolaemia, and hypertension decreased. The fully adjusted multivariate model reflected a statistically significant decrease in the HSI per unit increase in adherence to the MedDiet (beta = -0.075; 95% CI: -0.128, -0.021).Conclusion In individuals at high cardiovascular risk, adherence to the MedDiet is significantly associated with improvements in HSI. These longitudinal findings highlight the important role of the MedDiet in delaying or slowing the natural progression of MASLD, contributing to both its prevention and clinical management. C1 [Cueto-Galan, Raquel; Fontalba-Navas, Andres; Gutierrez-Bedmar, Mario; Munoz-Bravo, Carlos; Garcia-Rodriguez, Antonio; Gomez-Gracia, Enrique] Univ Malaga, Sch Med, Dept Publ Hlth & Psychiat, Malaga, Spain. [Cueto-Galan, Raquel; Fontalba-Navas, Andres; Gutierrez-Bedmar, Mario; Munoz-Bravo, Carlos; Garcia-Rodriguez, Antonio; Gomez-Gracia, Enrique] Biomed Res Inst Malaga IBIMA, Malaga, Spain. [Fontalba-Navas, Andres] Antequera Hosp, Northern Malaga Integrated Healthcare Area, Antequera, Spain. [Gutierrez-Bedmar, Mario] Inst Salud Carlos III ISCIII, CIBER Cardiovasc Dis CIBERCV, Madrid, Spain. [Ruiz-Canela, Miguel; Martinez-Gonzalez, Miguel A.] Univ Navarra, Sch Med, Dept Prevent Med & Publ Hlth, Pamplona, Spain. [Ruiz-Canela, Miguel; Martinez-Gonzalez, Miguel A.; Babio, Nancy; Fito, Montserrat; Ros, Emilio; Fiol, Miquel; Estruch, Ramon; Aros, Fernando; Serra-Majem, Luis; Pinto, Xavier] Inst Salud Carlos III ISCIII, CIBER Fisiopatol Obes & Nutr CIBEROBN, Madrid, Spain. [Martinez-Gonzalez, Miguel A.] Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA. [Alves, Lilian] Hosp Salut St Joan, Inst Invest Sanitaria Pere Virgili, Gastroenterol Dept, Food Nutr Dev & Mental Hlth Grp, Reus, Spain. [Babio, Nancy] Univ Rovira i Virgili, Dept Bioquim & Biotecnol, Grp ANUT DSM, Reus, Spain. [Babio, Nancy] Inst Invest Sanitaria Pere Virgili, Reus, Spain. [Fito, Montserrat] Hosp Mar Med Res Inst IMIM, Cardiovasc Risk & Nutr Res Grp, Barcelona, Spain. [Ros, Emilio] Hosp Clin Barcelona, Inst Invest Biomed August Pi I Sunyer IDIBAPS, Endocrinol & Nutr Serv, Lipid Clin, Barcelona, Spain. [Fiol, Miquel] Hosp Son Espases, Hlth Res Inst Balear Isl IdISBa, Palma De Mallorca, Spain. [Estruch, Ramon] Univ Barcelona, Hosp Clin, Dept Internal Med, IDIBAPS, Barcelona, Spain. [Aros, Fernando] Hosp Univ Alava, Dept Cardiol, Vitoria, Spain. [Serra-Majem, Luis] Univ Las Palmas Gran Canaria, Res Inst Biomed & Hlth Sci, Las Palmas Gran Canaria, Spain. [Serra-Majem, Luis] Univ Las Palmas Gran Canaria, Dept Clin Sci, Las Palmas Gran Canaria, Spain. [Pinto, Xavier] Hosp Univ Bellvitge, Internal Med Serv, Lipid & Vasc Risk Unit, Lhospitalet De Llobregat, Spain. C3 Universidad de Malaga; IBIMA Plataforma BIONAND, Instituto de Investigacion Biomedica de Malaga; Universidad de Malaga; CIBER - Centro de Investigacion Biomedica en Red; CIBERCV; University of Navarra; CIBER - Centro de Investigacion Biomedica en Red; CIBEROBN; Harvard University; Harvard T.H. Chan School of Public Health; Universitat Rovira i Virgili; Institut d'Investigacio Sanitaria Pere Virgili (IISPV); Universitat Rovira i Virgili; Universitat Rovira i Virgili; Institut d'Investigacio Sanitaria Pere Virgili (IISPV); Hospital del Mar Research Institute; Hospital del Mar; University of Barcelona; Hospital Clinic de Barcelona; IDIBAPS; Hospital Universitari Son Espases; Institut Investigacio Sanitaria Illes Balears (IdISBa); University of Barcelona; Hospital Clinic de Barcelona; IDIBAPS; University Hospital of Araba; Universidad de Las Palmas de Gran Canaria; Universidad de Las Palmas de Gran Canaria; Institut d'Investigacio Biomedica de Bellvitge (IDIBELL); Bellvitge University Hospital RP Fontalba-Navas, A (通讯作者)，Univ Malaga, Sch Med, Dept Publ Hlth & Psychiat, Malaga, Spain.; Fontalba-Navas, A (通讯作者)，Biomed Res Inst Malaga IBIMA, Malaga, Spain.; Fontalba-Navas, A (通讯作者)，Antequera Hosp, Northern Malaga Integrated Healthcare Area, Antequera, Spain. EM afontalba@uma.es RI Serra-Majem, Lluis/I-6708-2019; Babio, Nancy/AAN-2715-2020; Ruiz-Canela, Miguel/JYP-1794-2024; Martinez-Gonzalez, Miguel/AAE-7669-2019; Estruch, Ramon/AAZ-3723-2020; Fito, Montserrat/C-1822-2012; Gutiérrez-Bedmar, Mario/F-2364-2018; Fontalba-Navas, Anes/G-5180-2017 OI Gutiérrez-Bedmar, Mario/0000-0003-0898-8212; Fontalba-Navas, Anes/0000-0001-6670-9088; Cueto Galán, Raquel/0000-0001-5846-5685 FU Fundacion Progreso y Salud [AP-0306-2022-C3-F2] FX The author(s) declare that financial support was received for the research and/or publication of this article. This research was funded by the Fundacion Progreso y Salud (Project No. AP-0306-2022-C3-F2). The funder provided financial support for the professional translation of the manuscript. 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Nutr. PD MAY 21 PY 2025 VL 12 AR 1518082 DI 10.3389/fnut.2025.1518082 PG 12 WC Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Nutrition & Dietetics GA 3MH5I UT WOS:001503740200001 PM 40469667 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Brecelj, J Orel, R AF Brecelj, Jernej Orel, Rok TI Non-Alcoholic Fatty Liver Disease in Children SO MEDICINA-LITHUANIA LA English DT Review DE pediatric fatty liver disease; obesity; lifestyle modification; diet; physical activity ID TRANSIENT ELASTOGRAPHY; MEDITERRANEAN DIET; PEDIATRIC-PATIENTS; PHYSICAL-ACTIVITY; OBESE CHILDREN; LIFE-STYLE; ADOLESCENTS; NAFLD; NUTRITION; INTERVENTION AB Background and Objectives: The prevalence of pediatric non-alcoholic fatty liver disease is increasing. A lot of new data are published regularly. Materials and Methods: Original clinical studies, review articles, and guidelines in children were searched for and the most relevant included in this review. Results: A total of 138 retrieved papers were classified into pathogenesis, epidemiology, diagnosis, and treatment. Pathogenesis is currently explained with the "multi hit hypothesis", with complex interactions of genetic and environmental factors which trigger inflammation in steatotic liver. The prevalence is rising. A diagnosis can be made with laboratory tests, imaging, and liver biopsy after the exclusion of other causes of liver steatosis. The mainstay of treatment is lifestyle modification consisting of dietary intervention and increased physical activity. The progression to liver cirrhosis can occur even in children. Conclusions: Non-alcoholic fatty liver disease in children is a part of a metabolic syndrome in the majority of patients. Due to its complex etiology and high prevalence, multidisciplinary teams, together with public health professionals, should be involved in its treatment. C1 [Brecelj, Jernej; Orel, Rok] Univ Childrens Hosp Ljubljana, Dept Gastroenterol Hepatol & Nutr, Bohoriceva 20, SI-1000 Ljubljana, Slovenia. [Brecelj, Jernej; Orel, Rok] Univ Ljubljana, Fac Med, Dept Paediat, Bohoriceva 20, SI-1000 Ljubljana, Slovenia. C3 University Medical Centre Ljubljana; University of Ljubljana RP Brecelj, J (通讯作者)，Univ Childrens Hosp Ljubljana, Dept Gastroenterol Hepatol & Nutr, Bohoriceva 20, SI-1000 Ljubljana, Slovenia.; Brecelj, J (通讯作者)，Univ Ljubljana, Fac Med, Dept Paediat, Bohoriceva 20, SI-1000 Ljubljana, Slovenia. 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PD JUL PY 2021 VL 57 IS 7 AR 719 DI 10.3390/medicina57070719 PG 15 WC Medicine, General & Internal WE Science Citation Index Expanded (SCI-EXPANDED) SC General & Internal Medicine GA TN4TS UT WOS:000676229600001 PM 34357000 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Jiménez-González, C Alonso-Peña, M Vélez, PA Crespo, J Iruzubieta, P AF Jimenez-Gonzalez, Carolina Alonso-Pena, Marta Velez, Paula Argos Crespo, Javier Iruzubieta, Paula TI Unraveling MASLD: The Role of Gut Microbiota, Dietary Modulation, and AI-Driven Lifestyle Interventions SO NUTRIENTS LA English DT Review DE MASLD; gut microbiota; multi-omics; dietary patterns; lifestyle modifications; artificial intelligence ID FATTY LIVER-DISEASE; PROTEIN-COUPLED RECEPTOR; MEDITERRANEAN DIET; CONTROLLED-TRIAL; WEIGHT-LOSS; IMPACT; OBESITY; ACIDS; HOST; POLYPHENOLS AB Gut microbiota has a crucial role in the pathophysiology of metabolic-associated steatotic liver disease (MASLD), influencing various metabolic mechanisms and contributing to the development of the disease. Dietary interventions targeting gut microbiota have shown potential in modulating microbial composition and mitigating MASLD progression. In this context, the integration of multi-omics analysis and artificial intelligence (AI) in personalized nutrition offers new opportunities for tailoring dietary strategies based on individual microbiome profiles and metabolic responses. The use of chatbots and other AI-based health solutions offers a unique opportunity to democratize access to health interventions due to their low cost, accessibility, and scalability. Future research should focus on the clinical validation of AI-powered dietary strategies, integrating microbiome-based therapies and precision nutrition approaches. Establishing standardized protocols and ethical guidelines will be crucial for implementing AI in MASLD management, paving the way for a more personalized, data-driven approach to disease prevention and treatment. C1 [Jimenez-Gonzalez, Carolina; Alonso-Pena, Marta; Velez, Paula Argos; Crespo, Javier; Iruzubieta, Paula] Marques Valdecilla Univ Hosp, Valdecilla Res Inst IDIVAL, Gastroenterol & Hepatol Dept, Clin & Translat Res Digest Dis, Santander 39011, Spain. [Alonso-Pena, Marta] Univ Cantabria, Dept Anat & Biol Celular, Santander 39011, Spain. C3 Hospital Universitario Marques de Valdecilla (HUMV); Universidad de Cantabria RP Crespo, J (通讯作者)，Marques Valdecilla Univ Hosp, Valdecilla Res Inst IDIVAL, Gastroenterol & Hepatol Dept, Clin & Translat Res Digest Dis, Santander 39011, Spain. EM carolina.jimenez@idival.org; marta.alonso@unican.es; paula.argos@idival.org; javier.crespo@scsalud.es; p.iruzubieta@gmail.com RI Alonso Peña, Marta/IQW-4834-2023 OI Alonso Peña, Marta/0000-0003-0934-2202; Crespo, Javier/0000-0001-8248-0172 FU European Horizon's research and innovation program HORIZON-HLTH-2022-STAYHLTH-02 [HORIZON-HLTH-2022-STAYHLTH-02, 101095679]; European Horizon's research and innovation program [FIS-PI22/01853]; Spanish Instituto de Salud Carlos III-FEDER [PMP21/00112]; European Union-NextGenerationEU FX This project has received funding from the European Horizon's research and innovation program HORIZON-HLTH-2022-STAYHLTH-02 (agreement No. 101095679), Spanish Instituto de Salud Carlos III-FEDER Grant (FIS-PI22/01853) and European Union-NextGenerationEU (PMP21/00112). The funding sources were not involved in the research design or preparation of the article. 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J AU Grinshpan, LS Haim, YE Ivancovsky-Wajcman, D Fliss-Isakov, N Nov, Y Webb, M Shibolet, O Kariv, R Zelber-Sagi, S AF Grinshpan, Laura S. Haim, Yaara Even Ivancovsky-Wajcman, Dana Fliss-Isakov, Naomi Nov, Yuval Webb, Muriel Shibolet, Oren Kariv, Revital Zelber-Sagi, Shira TI A healthy lifestyle is prospectively associated with lower onset of metabolic dysfunction-associated steatotic liver disease SO HEPATOLOGY COMMUNICATIONS LA English DT Article DE fatty liver; healthy lifestyle index; insulin resistance; MASLD; steatohepatitis ID DIAGNOSTIC PERFORMANCE; MEDITERRANEAN DIET; ADHERENCE; OBESITY; INDEX; SCORE; RISK AB Background:Metabolic dysfunction-associated steatotic liver disease (MASLD) is associated with an unhealthy lifestyle. However, there is limited prospective evidence regarding the association between combined lifestyle factors and MASLD. This study aims to test the association of a combination of lifestyle components, expressed as a healthy lifestyle index (HLI), and unhealthful eating behavior habits with MASLD, insulin resistance (IR), liver fibrosis, and metabolic dysfunction-associated steatohepatitis.Methods:A prospective cohort study was conducted among participants of metabolic and hepatic screening surveys. MASLD was evaluated by ultrasonography or controlled attenuation parameter at 2 time points to assess new-onset, persistence, or remission, and IR was estimated by homeostasis model assessment. Presumed liver fibrosis and metabolic dysfunction-associated steatohepatitis were evaluated using FibroMax biomarkers. The HLI was calculated as the sum of 4 lifestyle components: nonsmoking, healthy weight, healthy diet, and physical activity.Results:The final cohort included 315 subjects with 6.7 years of follow-up, 40-70 years old. In multivariable analyses, a favorable lifestyle (>= 3 components) was independently associated with lower odds of new-onset MASLD (OR = 0.42; 95% CI: 0.19-0.90). Similarly, a favorable lifestyle was associated with lower odds of new-onset/persistent (vs. never/remission) MASLD and IR, respectively (OR = 0.49; 95% CI: 0.30-0.80; OR = 0.40; 95% CI: 0.24-0.66). There was a dose-response association between HLI and new-onset/persistent MASLD and IR. A favorable lifestyle was associated with lower odds of new-onset metabolic dysfunction-associated steatohepatitis (OR = 0.50; 95% CI: 0.27-0.95). Adjusting for HLI, unhealthful eating behavior habits were associated with higher odds of MASLD prevalence (OR = 1.81; 95% CI: 1.07-3.06).Conclusions:Adherence to a healthy lifestyle is prospectively associated with lower odds of MASLD, markers of liver damage, and IR. A holistic approach that considers overall lifestyle and eating behavior may be useful for preventing MASLD. C1 [Grinshpan, Laura S.; Haim, Yaara Even; Ivancovsky-Wajcman, Dana; Nov, Yuval; Zelber-Sagi, Shira] Univ Haifa, Fac Social Welf & Hlth Sci, Sch Publ Hlth, 199 Aba Khoushy Ave, IL-3498838 Haifa, Israel. [Grinshpan, Laura S.; Haim, Yaara Even; Ivancovsky-Wajcman, Dana; Fliss-Isakov, Naomi; Webb, Muriel; Shibolet, Oren; Kariv, Revital; Zelber-Sagi, Shira] Tel Aviv Med Ctr & Sch Med, Dept Gastroenterol, Tel Aviv, Israel. [Fliss-Isakov, Naomi] Tel Aviv Univ, Fac Med, Sch Publ Hlth, Dept Hlth Promot, Tel Aviv, Israel. [Webb, Muriel; Shibolet, Oren; Kariv, Revital] Tel Aviv Univ, Fac Med, Tel Aviv, Israel. C3 University of Haifa; Tel Aviv University; Sackler Faculty of Medicine; Tel Aviv University; Tel Aviv University RP Zelber-Sagi, S (通讯作者)，Univ Haifa, Fac Social Welf & Hlth Sci, Sch Publ Hlth, 199 Aba Khoushy Ave, IL-3498838 Haifa, Israel. EM laurasolll@gmail.com; yaararot@gmail.com; danaivanc@gmail.com; naomi.fliss@moh.gov.il; ynov@univ.haifa.ac.il; murielw@tlvmc.gov.il; orensh@tlvmc.gov.il; revitalk@tlvmc.gov.il; szelber-s@univ.haifa.ac.il RI ; Ivancovsky-Wajcman, Dana/HDO-6146-2022; Kariv, Revital/HLW-2074-2023 OI Nov, Yuval/0000-0002-2965-4791; FU Research Grant Fund on Food and Nutrition and their Implications on Public Health; Israeli Ministry of Health [3-0000-16286] FX This work was supported by the Research Grant Fund on Food and Nutrition and their Implications on Public Health, The Israeli Ministry of Health (grant number 3-0000-16286). The Israeli Ministry of Health department had no role in the design, analysis, or writing of this article. 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Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Nutrition & Dietetics GA 3BJ0B UT WOS:001496284100001 PM 40431384 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Zeng, Z Wei, H Dong, YJ Sun, SJ Sunu, Z AF Zeng, Zi Wei, Hua Dong, Yuejuan Sun, Sijin Sunu, Zhuoma TI What diet is optimal in adults with metabolic dysfunction-associated steatotic liver disease? A systematic review and network meta-analysis SO NUTRITION CLINIQUE ET METABOLISME LA English DT Article DE Adults; Metabolic dysfunction-associated steatotic; liver disease; Diet; Network meta-analysis; Non-alcoholic fatty liver disease ID LOW-CARBOHYDRATE; MEDITERRANEAN DIET; GUT MICROBIOTA; WEIGHT-LOSS; LIFE-STYLE; INTERVENTION; EPIDEMIOLOGY; CALORIE; BURDEN AB Objective. - To evaluate the effects of various dietary regimens on adult patients with metabolic dysfunction-associated steatotic liver disease. Methods. - Randomized controlled trials of various dietary regimens in patients with metabolic dysfunction-associated steatotic liver disease (MASLD), published up to October 6th, 2024, were included in this study. The Cochrane Collaboration tool was employed to assess the risk of bias for quality evaluation. STATA 17.0 software was utilized for both pairwise meta-analysis and a series of network meta-analyses (NMA). Results. - A total of 19 randomized controlled trials (RCTs) from 22 studies involving 1288 patients were included, focusing on 12 different dietary approaches. The findings indicated that the recommended diet varied based on different outcome measures. The very low-calorie ketogenic diet (VLCKD) was found to be the most effective for reducing body weight, body mass index (BMI), and waist circumference. In contrast, the Dietary Approaches to Stop Hypertension (DASH) was more effective in lowering blood lipid levels. Regarding liver enzyme indicators, the results were inconsistent, leading to no specific recommendations. Additionally, the low free sugar diet (LFSD) demonstrated greater benefits in improving glucose metabolism indicators. Conclusions. - The VLCKD is more effective for improving anthropometric indicators, while the DASH diet is more suitable for enhancing lipid indicators. There is currently no standardized dietary recommendation for alleviating liver enzyme indicators. The LFSD has proven to be more effective for parameters related to glucose metabolism indicators. Clinical applications should be tailored to the individual circumstances of each patient. (c) 2025 Societe francophone nutrition clinique et metabolisme (SFNCM). Published by Elsevier Masson SAS. All rights are reserved, including those for text and data mining, AI training, and similar technologies. C1 [Zeng, Zi; Wei, Hua; Dong, Yuejuan] Henan Vocat Coll Nursing, Dept Nursing, 480 Zhonghua Rd, Anyang 455000, Peoples R China. [Sun, Sijin] Neijiang Hlth Vocat Coll, Dept Nurisng, 368,East Sect 4,Hanan Ave, Neijiang 641100, Sichuan, Peoples R China. [Sunu, Zhuoma] Tohoku Univ, Grad Sch Med, Dept Hlth Sci, 2-1 Seiryo Machi,Aoba Ku, Sendai, Miyagi 9800872, Japan. C3 Tohoku University RP Zeng, Z (通讯作者)，Henan Vocat Coll Nursing, Dept Nursing, 480 Zhonghua Rd, Anyang 455000, Peoples R China. EM yxzengzi@163.com; 15236537205@163.com; henanhuli@163.com; 346225525@qq.com; snzm3057@gmail.com RI Sun, Sijin/AGA-3676-2022; wei, hua/LRD-0771-2024 CR Abd El-Kader SM, 2016, AFR HEALTH SCI, V16, P242, DOI 10.4314/ahs.v16i1.32 Alami F, 2022, SCAND J GASTROENTERO, V57, P1238, DOI 10.1080/00365521.2022.2071109 Asghari S, 2022, NUTRIENTS, V14, DOI 10.3390/nu14122509 Badali T, 2023, HEALTH PROMOT PERSPE, V13, P77, DOI 10.34172/hpp.2023.10 Cai H, 2019, BMC GASTROENTEROL, V19, DOI 10.1186/s12876-019-1132-8 Canivet CM, 2024, SEMIN LIVER DIS, V44, P35, DOI 10.1055/s-0044-1785196 Cernea S, 2023, Acta Marisiensis - Seria Medica, V69, P3, DOI [10.2478/amma-2023-0001, 10.2478/amma-2023-0001, DOI 10.2478/AMMA-2023-0001] Chaimani A, 2017, EVID-BASED MENT HEAL, V20, P88, DOI 10.1136/eb-2017-102753 Chen J, 2020, ASIA PAC J CLIN NUTR, V29, P483, DOI 10.6133/apjcn.202009_29(3).0006 Cunha GM, 2020, FRONT ENDOCRINOL, V11, DOI 10.3389/fendo.2020.00607 De Chiara F, 2019, NUTRIENTS, V11, DOI 10.3390/nu11122985 Del Bo' C, 2023, NUTRIENTS, V15, DOI 10.3390/nu15102250 Deng Y, 2024, OBESITY, V32, P494, DOI 10.1002/oby.23965 Dorosti M, 2020, BRIT J NUTR, V123, P328, DOI 10.1017/S0007114519002769 European Association for the Study of the Liver (EASL), 2016, J Hepatol, V64, P1388, DOI 10.1016/j.jhep.2015.11.004 Fateh HL, 2023, FRONT NUTR, V10, DOI 10.3389/fnut.2023.1181706 Franco I, 2021, NUTRIENTS, V13, DOI 10.3390/nu13010066 Garcêz LS, 2021, NUTR REV, V79, P1321, DOI 10.1093/nutrit/nuaa146 Garousi N, 2023, ARCH PHYSIOL BIOCHEM, V129, P975, DOI 10.1080/13813455.2021.1890128 George ES, 2022, LIVER INT, V42, P1308, DOI 10.1111/liv.15264 Ghetti FD, 2019, J GASTROINTEST LIVER, V28, P279, DOI 10.15403/jgld-197 Golabi P, 2021, J HEPATOL, V75, P795, DOI 10.1016/j.jhep.2021.05.022 Haigh L, 2022, CLIN NUTR, V41, P1913, DOI 10.1016/j.clnu.2022.06.037 He KY, 2022, AM J GASTROENTEROL, V117, P1621, DOI 10.14309/ajg.0000000000001885 Higgins JP, 2011, Cochrane handbook for systematic reviews of interventions Higgins JPT, 2011, BMJ-BRIT MED J, V343, DOI 10.1136/bmj.d5928 Hutton B, 2015, ANN INTERN MED, V162, P777, DOI 10.7326/M14-2385 Jang EC, 2018, HEPATOL RES, V48, pE22, DOI 10.1111/hepr.12918 Kani AH, 2017, HORM METAB RES, V49, P687, DOI 10.1055/s-0042-118707 Kani AH, 2014, NUTRITION, V30, P814, DOI 10.1016/j.nut.2013.11.008 Katsagoni CN, 2018, BRIT J NUTR, V120, P164, DOI [10.1017/S000711451800137X, 10.1017/s000711451800137x] Kestane VU, 2024, NUTRIENTS, V16, DOI 10.3390/nu16162699 Khodami B, 2022, EUR J CLIN NUTR, V76, P987, DOI 10.1038/s41430-022-01081-x Kongmalai T, 2023, FRONT ENDOCRINOL, V14, DOI 10.3389/fendo.2023.1182037 Kord-Varkaneh H, 2023, NUTRITION, V105, DOI 10.1016/j.nut.2022.111847 Lee D, 2022, NUTRIENTS, V14, DOI 10.3390/nu14142846 Li J, 2019, LANCET GASTROENTEROL, V4, P389, DOI 10.1016/S2468-1253(19)30039-1 Masarone M, 2014, REV RECENT CLIN TRIA, V9, P126, DOI 10.2174/1574887109666141216111143 Mascaro CM, 2022, NUTRIENTS, V14, DOI 10.3390/nu14010049 Meir AY, 2021, GUT, V70, P2085, DOI 10.1136/gutjnl-2020-323106 Misciagna G, 2017, J NUTR HEALTH AGING, V21, P404, DOI 10.1007/s12603-016-0809-8 Perumpail BJ, 2017, WORLD J GASTROENTERO, V23, P8263, DOI 10.3748/wjg.v23.i47.8263 Properzi C, 2018, HEPATOLOGY, V68, P1741, DOI 10.1002/hep.30076 Reddy A, 2023, NUTR RES, V119, P98, DOI 10.1016/j.nutres.2023.09.005 Riazi K, 2022, LANCET GASTROENTEROL, V7, P851, DOI 10.1016/S2468-1253(22)00165-0 Rinella ME, 2023, J HEPATOL, V79, P1542, DOI 10.1016/j.jhep.2023.06.003 Ristic-Medic D, 2021, NUTRIENTS, V13, DOI 10.3390/nu13010015 Rooholahzadegan F, 2023, NUTR METAB, V20, DOI 10.1186/s12986-023-00733-4 Salanti G, 2012, RES SYNTH METHODS, V3, P80, DOI 10.1002/jrsm.1037 Sangouni AA, 2024, EUR J NUTR, V63, P95, DOI 10.1007/s00394-023-03221-w Trépo E, 2020, J HEPATOL, V72, P1196, DOI 10.1016/j.jhep.2020.02.020 Varkaneh HK, 2022, FRONT NUTR, V9, DOI 10.3389/fnut.2022.948655 Wang XC, 2023, FRONT PHARMACOL, V14, DOI 10.3389/fphar.2023.1180016 Wei XY, 2023, JAMA NETW OPEN, V6, DOI 10.1001/jamanetworkopen.2023.3513 Younossi ZM, 2021, GASTROENTEROLOGY, V160, P912, DOI 10.1053/j.gastro.2020.11.051 Younossi ZM, 2023, HEPATOLOGY, V77, P1335, DOI 10.1097/HEP.0000000000000004 Zare Z, 2023, FRONT NUTR, V10, DOI 10.3389/fnut.2023.1163516 Zhu YZ, 2024, ANTIOXIDANTS-BASEL, V13, DOI 10.3390/antiox13030329 NR 58 TC 0 Z9 0 U1 0 U2 0 PU MASSON EDITEUR PI MOULINEAUX CEDEX 9 PA 21 STREET CAMILLE DESMOULINS, ISSY, 92789 MOULINEAUX CEDEX 9, FRANCE SN 0985-0562 EI 1768-3092 J9 NUTR CLIN METAB JI Nutr. Clin. Metab. PD DEC PY 2025 VL 39 IS 4 BP 319 EP 333 DI 10.1016/j.nupar.2025.08.004 EA NOV 2025 PG 15 WC Endocrinology & Metabolism; Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Endocrinology & Metabolism; Nutrition & Dietetics GA M7655 UT WOS:001630899800011 DA 2026-02-02 ER PT J AU Pastore, MN Bonfiglio, C Tatoli, R Donghia, R Pesole, PL Giannelli, G AF Pastore, Maria Noemy Bonfiglio, Caterina Tatoli, Rossella Donghia, Rossella Pesole, Pasqua Letizia Giannelli, Gianluigi TI Optimal Vegetable Intake for Metabolic-Dysfunction-Associated Steatotic Liver Disease (MASLD) Prevention: Insights from a South Italian Cohort SO NUTRIENTS LA English DT Article DE metabolic-dysfunction-associated steatotic liver disease (MASLD); color vegetable; mediterranean diet ID MEDITERRANEAN DIET; POPULATION AB (1) Background: Metabolic-dysfunction-associated steatotic liver disease (MASLD) is now the most prevalent chronic liver disease worldwide, posing a growing public health concern. While dietary improvements are key to prevention, the impact of different vegetable types remains unclear. This study focuses on the association between vegetable consumption and the risk of MASLD in a cohort of Southern Italy. (2) Methods: This research involved 1297 participants from the NUTRIHEP study, examining overall vegetable intake and classifying them into color subgroups to determine optimal quantity and variety for risk reduction. (3) Results: Daily consumption of approximately 325 g (two servings) of total vegetables significantly reduces the risk of MASLD (OR: 0.521; 95% CI: 0.317; 0.858). Among the subgroups, green vegetables were most protective at 35 g/day, while red and orange vegetables offered protection at 130 g/day. A higher intake of the other vegetable category, specifically onions, was associated with a reduced probability of MASLD (OR = 0.995; 95%CI: 0.989; 0.999). (4) Conclusions: These findings suggest a threshold effect, where moderate but regular consumption of specific vegetables offers maximal protection. Consuming excessive amounts may not enhance this benefit within this cohort. Cultural and regional dietary patterns should be considered when designing targeted nutritional interventions. C1 [Pastore, Maria Noemy; Bonfiglio, Caterina; Tatoli, Rossella; Donghia, Rossella] Natl Inst Gastroenterol IRCCS Saverio de Bellis, Unit Data Sci, I-70013 Bari, Italy. [Pesole, Pasqua Letizia] Natl Inst Gastroenterol IRCCS Saverio de Bellis, Core Facil Biobank, I-70013 Bari, Italy. [Giannelli, Gianluigi] Natl Inst Gastroenterol IRCCS Saverio de Bellis, Sci Direct, I-70013 Bari, Italy. C3 IRCCS Saverio de Bellis; IRCCS Saverio de Bellis; IRCCS Saverio de Bellis RP Bonfiglio, C (通讯作者)，Natl Inst Gastroenterol IRCCS Saverio de Bellis, Unit Data Sci, I-70013 Bari, Italy. EM noemy.pastore@irccsdebellis.it; catia.bonfiglio@irccsdebellis.it; rossella.tatoli@irccsdebellis.it; rossella.donghia@irccsdebellis.it; letizia.pesole@irccsdebellis.it; gianluigi.giannelli@irccsdebellis.it RI ; Giannelli, Gianluigi/A-8169-2012 OI Bonfiglio, Caterina/0000-0002-8650-348X; Tatoli, Rossella/0000-0002-7891-6057; pesole, pasqua letizia/0000-0003-4675-2075; Giannelli, Gianluigi/0000-0002-5140-8060; Donghia, Rossella/0000-0002-9140-673X FU Italian Ministry of Health; Italian Ministry of Health with Ricerca Corrente 2025 FX This research was funded by the Italian Ministry of Health with Ricerca Corrente 2025. 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OA Green Submitted, gold DA 2026-02-02 ER PT J AU Stachowska, E Gudan, A Mankowska-Wierzbicka, D Liebe, R Krawczyk, M AF Stachowska, Ewa Gudan, Anna Mankowska-Wierzbicka, Dorota Liebe, Roman Krawczyk, Marcin TI Dysbiosis and nutrition in steatotic liver disease: addressing the unrecognized small intestinal bacterial overgrowth (SIBO) challenge SO INTERNAL AND EMERGENCY MEDICINE LA English DT Review DE Diet; Fatty liver; Intestinal symptoms ID IRRITABLE-BOWEL-SYNDROME; LOW FODMAP DIET; PRACTICE GUIDANCE; MANAGEMENT; ASSOCIATION; DIAGNOSIS AB Steatotic liver disease (SLD) is characterized by hepatic fat accumulation, potentially causing major consequences such as liver decompensation. Currently, we lack medications for the treatment of SLD. Therapeutic recommendations for patients include a hypocaloric diet, weight loss, and physical activity. In particular, the Mediterranean diet is frequently recommended. However, this diet might exacerbate intestinal problems in a subset of patients with coexisting small intestinal bacterial overgrowth (SIBO). Previous studies have reported that SIBO is more predominant in patients with fatty liver than in healthy individuals. Both our research and the findings of others have highlighted a challenge related to nutritional therapy in patients with fatty liver who also suffer from SIBO inasmuch as SIBO induces several phenomena (like bloating or abdominal pain) that can adversely affect patients' quality of life and might be exacerbated by the Mediterranean diet. This may lower their adherence to the intervention. As a solution, we suggest introducing additional diagnostics (e.g., breath test) in patients with SLD who complain of SIBO-like symptoms. The next step is to modify their diets temporarily starting with several weeks of "elimination and sanitation." This would involve restricting products rich in fermentable sugars and polyols, while simultaneously treating the bacterial overgrowth. In summary, while the hypocaloric Mediterranean diet is beneficial for patients with fatty liver, those with coexisting SIBO may experience exacerbated symptoms. It is vital to consider additional diagnostics and dietary modifications for this subset of patients to address both liver and intestinal health concurrently. C1 [Stachowska, Ewa; Gudan, Anna] Pomeranian Med Univ, Dept Human Nutr & Metabol, Broniewskiego 24, PL-71460 Szczecin, Poland. [Mankowska-Wierzbicka, Dorota] Poznan Univ Med Sci, Dept Gastroenterol Dietet & Internal Dis, Poznan, Poland. [Liebe, Roman] Otto Guericke Univ, Gastroenterol Clin Hepatol & Infect Dis, Magdeburg, Germany. [Krawczyk, Marcin] Saarland Univ, Saarland Univ Med Ctr, Dept Med II, Homburg, Germany. [Krawczyk, Marcin] Med Univ Warsaw, Ctr Preclin Res, Lab Metab Liver Dis, Warsaw, Poland. C3 Pomeranian Medical University; Poznan University of Medical Sciences; Otto von Guericke University; Universitatsklinikum des Saarlandes; Medical University of Warsaw RP Stachowska, E (通讯作者)，Pomeranian Med Univ, Dept Human Nutr & Metabol, Broniewskiego 24, PL-71460 Szczecin, Poland. EM ewa.stachowska@pum.edu.pl RI Krawczyk, Marcin/AAG-4356-2020; stachowska, Ewa/G-9521-2017; Mankowska-Wierzbicka, Dorota/AAM-9488-2020; Gudan, Anna/CBJ-5392-2022 OI Krawczyk, Marcin/0000-0002-0113-0777; FU German ministry of education and research (BMBF) [01GM1904A]; Polish National Science Center (NCN) [CN82K]; Pomeranian Medical University in Szczecin, Poland [PUM 330-01/S/23] FX R.L. received funding from the German ministry of education and research (BMBF) through HiChol (01GM1904A). M.K. received funding from the Polish National Science Center (NCN, grant number: CN82K). E.S. received funding from the Pomeranian Medical University in Szczecin, Poland (PUM 330-01/S/23). 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Emerg. Med. PD AUG PY 2024 VL 19 IS 5 BP 1229 EP 1234 DI 10.1007/s11739-024-03533-7 EA MAR 2024 PG 6 WC Medicine, General & Internal WE Science Citation Index Expanded (SCI-EXPANDED) SC General & Internal Medicine GA M9N2S UT WOS:001186154100001 PM 38499938 DA 2026-02-02 ER PT J AU Rajewski, P Ciescinski, J Rajewski, P Suwala, S Rajewska, A Potasz, M AF Rajewski, Pawel Ciescinski, Jakub Rajewski, Piotr Suwala, Szymon Rajewska, Alicja Potasz, Maciej TI Dietary Interventions and Physical Activity as Crucial Factors in the Prevention and Treatment of Metabolic Dysfunction-Associated Steatotic Liver Disease SO BIOMEDICINES LA English DT Review DE lifestyle; MASLD; non-pharmacological treatment; diet; physical activity; hepatic steatosis; cardiovascular disease; obesity; diabetes ID WEIGHT-LOSS; LIFE-STYLE; MEDITERRANEAN DIET; AEROBIC EXERCISE; HEPATOCELLULAR-CARCINOMA; HEPATIC STEATOSIS; PRACTICE GUIDANCE; FAT; MANAGEMENT; HEALTH AB Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic liver disease worldwide and affects nearly 30% of the adult population and 10% of the pediatric population. It is estimated that this number will double by 2030. MASLD is one of the leading causes of hepatocellular carcinoma, cirrhosis, and liver transplantation, as well as a significant risk factor for cardiovascular disease and mortality. Due to the ever-increasing number of patients, the long-term asymptomatic course of the disease, serious complications, and lack of preventive programs, as well as insufficient awareness of the disease among patients and doctors themselves, MASLD is a growing interdisciplinary problem and a real challenge for modern medicine. The main cause of MASLD is an inappropriate lifestyle-inadequate nutrition and insufficient physical activity, which lead to various components of metabolic syndrome. Lifestyle changes-appropriate diet, weight reduction, and systematic physical activity-are also the basis for the prevention and treatment of MASLD. Hence, in recent years, so much importance has been attached to lifestyle medicine, to non-pharmacological treatment as prevention of lifestyle diseases. The narrative review presents possible therapeutic options for non-pharmacological management in the prevention and treatment of MASLD. The best documented and available diets used in MASLD were discussed, focusing on the benefits and drawbacks of the Mediterranean, high-protein, ketogenic, and intermittent fasting diets. In addition, the most recent recommendations regarding physical activity are summarized. C1 [Rajewski, Pawel] Prov Infect Dis Hosp, Dept Internal & Infect Dis, PL-85030 Bydgoszcz, Poland. [Rajewski, Pawel] Univ Hlth Sci Bydgoszcz, Fac Hlth Sci, PL-85067 Bydgoszcz, Poland. [Ciescinski, Jakub] Prov Infect Dis Hosp, Dept Radiol, PL-85030 Bydgoszcz, Poland. [Rajewski, Piotr] Nicolaus Copernicus Univ Torun, Fac Med, Dept Neurol, Coll Medicum, PL-85094 Torun, Poland. [Suwala, Szymon] Nicolaus Copernicus Univ Torun, Fac Med, Dept Endocrinol & Diabetol, Coll Medicum, PL-85094 Bydgoszcz, Poland. [Rajewska, Alicja; Potasz, Maciej] Univ Clin Hosp, PL-60355 POZNAN, Poland. C3 Nicolaus Copernicus University; Nicolaus Copernicus University RP Rajewski, P (通讯作者)，Prov Infect Dis Hosp, Dept Internal & Infect Dis, PL-85030 Bydgoszcz, Poland.; Rajewski, P (通讯作者)，Univ Hlth Sci Bydgoszcz, Fac Hlth Sci, PL-85067 Bydgoszcz, Poland. 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SO ANTIOXIDANTS LA English DT Review DE ROS; oxidative stress; MAFLD; MD; EVOO ID NONALCOHOLIC FATTY LIVER; VIRGIN OLIVE OIL; MEDITERRANEAN-STYLE DIET; VITAMIN-E TREATMENT; AMINOTRANSFERASE LEVELS; METABOLIC SYNDROME; ENDOTHELIAL DYSFUNCTION; URSODEOXYCHOLIC ACID; INSULIN-RESISTANCE; PRESCRIPTIVE DIET AB Oxidative stress plays a central role in most chronic liver diseases and, in particular, in metabolic dysfunction-associated fatty liver disease (MAFLD), the new definition of an old condition known as non-alcoholic fatty liver disease (NAFLD). The mechanisms leading to hepatocellular fat accumulation in genetically predisposed individuals who adopt a sedentary lifestyle and consume an obesogenic diet progress through mitochondrial and endoplasmic reticulum dysfunction, which amplifies reactive oxygen species (ROS) production, lipid peroxidation, malondialdehyde (MDA) formation, and influence the release of chronic inflammation and liver damage biomarkers, such as pro-inflammatory cytokines. This close pathogenetic link has been a key stimulus in the search for therapeutic approaches targeting oxidative stress to treat steatosis, and a number of clinical trials have been conducted to date on subjects with NAFLD using drugs as well as supplements or nutraceutical products. Vitamin E, Vitamin D, and Silybin are the most studied substances, but several non-pharmacological approaches have also been explored, especially lifestyle and diet modifications. Among the dietary approaches, the Mediterranean Diet (MD) seems to be the most reliable for affecting liver steatosis, probably with the added value of the presence of extra virgin olive oil (EVOO), a healthy food with a high content of monounsaturated fatty acids, especially oleic acid, and variable concentrations of phenols (oleocanthal) and phenolic alcohols, such as hydroxytyrosol (HT) and tyrosol (Tyr). In this review, we focus on non-pharmacological interventions in MAFLD treatment that target oxidative stress and, in particular, on the role of EVOO as one of the main antioxidant components of the MD. C1 [Seidita, Aurelio; Giuliano, Alessandra; Meli, Maria; Carroccio, Antonio] Univ Palermo, V Cervello Hosp, Dept Hlth Promot Sci, Unit Internal Med,Osped Riuniti Villa Sofia Cervel, I-90146 Palermo, Italy. [Seidita, Aurelio; Cusimano, Alessandra; Giannitrapani, Lydia] Natl Res Council CNR, Inst Biomed Res & Innovat IRIB, I-90146 Palermo, Italy. [Soresi, Maurizio; Giannitrapani, Lydia] Univ Palermo, Univ Hosp P Giaccone, Dept Hlth Promot Sci Maternal & Infant Care, Unit Internal Med, I-90127 Palermo, Italy. C3 University of Palermo; Consiglio Nazionale delle Ricerche (CNR); Istituto Ricerca l'Innovazione Biomedica (IRIB-CNR); University of Palermo; Policlinico Paolo Giaccone RP Giannitrapani, L (通讯作者)，Natl Res Council CNR, Inst Biomed Res & Innovat IRIB, I-90146 Palermo, Italy.; Giannitrapani, L (通讯作者)，Univ Palermo, Univ Hosp P Giaccone, Dept Hlth Promot Sci Maternal & Infant Care, Unit Internal Med, I-90127 Palermo, Italy. EM aurelio.seidita@unipa.it; alessandra.cusimano01@unipa.it; alegiuliano94@gmail.com; maria.meli@unipa.it; antonio.carroccio@unipa.it; maurizio.soresi@unipa.it; lydia.giannitrapani@unipa.it RI ; Seidita, Aurelio/IQT-5629-2023 OI Giannitrapani, Lydia/0000-0003-2845-5296; Soresi, Maurizio/0000-0001-7850-555X; Giuliano, Alessana/0000-0002-9423-5462; Seidita, Aurelio/0000-0003-4080-2641; Cusimano, Alessana/0000-0002-3595-8898 FU European Union-PON Research and Innovation 2014-2020 [DM1062/2021] FX This research was co-financed by the European Union-PON Research and Innovation 2014-2020-DM1062/2021. The funder had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results. 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Zaneta Ternianov, Alexandre Unwin, David TI Beneficial Effects of the Ketogenic Diet on Nonalcoholic Fatty Liver Disease (NAFLD/MAFLD) SO JOURNAL OF CLINICAL MEDICINE LA English DT Review DE nonalcoholic fatty liver disease (NAFLD); metabolic (dysfunction)-associated fatty liver disease (MAFLD); liver; ketogenic diet; low carb; insulin resistance; weight loss; microbiome; self-monitoring; treatment ID LOW-CARBOHYDRATE-DIET; GUT MICROBIOTA; INSULIN-RESISTANCE; WEIGHT-LOSS; STEATOHEPATITIS NASH; MEDITERRANEAN DIET; METABOLIC SYNDROME; HEPATIC STEATOSIS; APPETITE; RESTRICTION AB The prevalence of nonalcoholic fatty liver disease (NAFLD) is likely to be approaching 38% of the world's population. It is predicted to become worse and is the main cause of morbidity and mortality due to hepatic pathologies. It is particularly worrying that NAFLD is increasingly diagnosed in children and is closely related, among other conditions, to insulin resistance and metabolic syndrome. Against this background is the concern that the awareness of patients with NAFLD is low; in one study, almost 96% of adult patients with NAFLD in the USA were not aware of their disease. Thus, studies on the therapeutic tools used to treat NAFLD are extremely important. One promising treatment is a well-formulated ketogenic diet (KD). The aim of this paper is to present a review of the available publications and the current state of knowledge of the effect of the KD on NAFLD. This paper includes characteristics of the key factors (from the point of view of NAFLD regression), on which ketogenic diet exerts its effects, i.e., reduction in insulin resistance and body weight, elimination of fructose and monosaccharides, limitation of the total carbohydrate intake, anti-inflammatory ketosis state, or modulation of gut microbiome and metabolome. In the context of the evidence for the effectiveness of the KD in the regression of NAFLD, this paper also suggests the important role of taking responsibility for one's own health through increasing self-monitoring and self-education. C1 [Dynka, Damian; Rodzen, Lukasz; Rodzen, Mateusz] Rodzen Bros Fdn, PL-64234 Wielen, Poland. [Lojko, Dorota] Poznan Univ Med Sci, Dept Psychiat, PL-60572 Poznan, Poland. [Kraszewski, Sebastian] Wroclaw Univ Sci & Technol, Fac Fundamental Problems Technol, Dept Biomed Engn, PL-50370 Wroclaw, Poland. [Ibrahim, Ali] Schoen Inpatient Childrens Eating Disorders Serv, 147 Chester Rd,Streetly, Sutton Coldfield B74 3NE, England. [Hussey, Maria] Private Gen Med Practice Mar Hussey, Ojcowa Wola 5, PL-14420 Mlynary, Poland. [Deptula, Adam; Grzywacz, Zaneta] Opole Univ Technol, Fac Prod Engn & Logist, 76 Proszkowska St, PL-45758 Opole, Poland. [Ternianov, Alexandre] Parc Sanit Pere Virgili, Primary Care Ctr Vila Olimp, C Joan Miro 17, Barcelona 08005, Spain. [Unwin, David] Edge Hill Univ, Fac Hlth Social Care & Med, Ormskirk L39 4QP, England. C3 Poznan University of Medical Sciences; Wroclaw University of Science & Technology; Opole University of Technology; Edge Hill University RP Dynka, D (通讯作者)，Rodzen Bros Fdn, PL-64234 Wielen, Poland. EM damian.dynka24@gmail.com RI ; Deptuła, Adam/L-8304-2015; Grzywacz, Żaneta/X-8124-2019; Kraszewski, Sebastian/ABA-9541-2021 OI Ternianov, Alexane/0000-0003-0239-0965; Dyńka, Damian/0000-0002-4544-9624; Deptuła, Adam/0000-0003-3017-5998; Grzywacz, Żaneta/0000-0001-6278-6924; Kraszewski, Sebastian/0000-0003-3244-7694 FU Rodzen Brothers Foundation, Poland FX The publication was financed by Rodzen Brothers Foundation, 64-234 Wielen, Poland. 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Clin. Med. PD AUG PY 2024 VL 13 IS 16 AR 4857 DI 10.3390/jcm13164857 PG 27 WC Medicine, General & Internal WE Science Citation Index Expanded (SCI-EXPANDED) SC General & Internal Medicine GA E8K0Y UT WOS:001305423700001 PM 39200999 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Stefano, JT Duarte, SMB Altikes, RGRL Oliveira, CP AF Stefano, Jose Tadeu Duarte, Sebastiao Mauro Bezerra Altikes, Renato Gama Ribeiro Leite Oliveira, Claudia P. P. TI Non-pharmacological management options for MAFLD: a practical guide SO THERAPEUTIC ADVANCES IN ENDOCRINOLOGY AND METABOLISM LA English DT Review DE dietary pattern; lifestyle changes; metabolic dysfunction-associated fatty liver disease (MAFLD); nonalcoholic fatty liver disease (NAFLD); physical exercise ID FATTY-LIVER-DISEASE; CARDIOVASCULAR RISK-FACTORS; CARDIAC AUTONOMIC CONTROL; LIFE-STYLE; NONALCOHOLIC STEATOHEPATITIS; MEDITERRANEAN DIET; INSULIN-RESISTANCE; METABOLIC SYNDROME; POSTMENOPAUSAL WOMEN; PHYSICAL-ACTIVITY AB Lifestyle changes should be the main basis for any treatment for metabolic dysfunction-associated fatty liver disease (MAFLD), aiming to increase energy expenditure, reduce energy intake and improve the quality of nutrients consumed. As it is a multifactorial disease, approaches such as physical exercise, a better dietary pattern, and possible pharmacological intervention are shown to be more efficient when used simultaneously to the detriment of their applications. The main treatment for MAFLD is a lifestyle change consisting of diet, activity, exercise, and weight loss. The variables for training prescription such as type of physical exercise (aerobic or strength training), the weekly frequency, and the intensity most indicated for the treatment of MAFLD remain uncertain, that is, the recommendations must be adapted to the clinical conditions comorbidities, and preferences of each subject in a way individual. This review addresses recent management options for MAFLD including diet, nutrients, gut microbiota, and physical exercise. C1 [Stefano, Jose Tadeu; Duarte, Sebastiao Mauro Bezerra; Oliveira, Claudia P. P.] Univ Sao Paulo, Hosp Clin HCFMUSP, Fac Med, Dept Gastroenterol,Lab Gastroenterol Clin & Expt, Sao Paulo, Brazil. [Altikes, Renato Gama Ribeiro Leite; Oliveira, Claudia P. P.] Univ Sao Paulo, Dept Gastroenterol, Fac Med, Sao Paulo, Brazil. Univ Sao Paulo, Ave Dr Eneas Carvalho Aguiar 255, 9159, BR-05403000 Sao Paulo, Brazil. Univ Sao Paulo, Fac Med, Dept Gastroenterol, Sao Paulo, Brazil. C3 Universidade de Sao Paulo; Universidade de Sao Paulo; Universidade de Sao Paulo; Universidade de Sao Paulo RP Oliveira, CP (通讯作者)，Univ Sao Paulo, Hosp Clin HCFMUSP, Fac Med, Dept Gastroenterol,Lab Gastroenterol Clin & Expt, Sao Paulo, Brazil.; Oliveira, CP (通讯作者)，Univ Sao Paulo, Dept Gastroenterol, Fac Med, Sao Paulo, Brazil. 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Adv. Endocrinol. Metab. PY 2023 VL 14 AR 20420188231160394 DI 10.1177/20420188231160394 PG 17 WC Endocrinology & Metabolism WE Science Citation Index Expanded (SCI-EXPANDED) SC Endocrinology & Metabolism GA 9Z3UD UT WOS:000951068000001 PM 36968655 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Ali, H Shahzil, M Moond, V Shahzad, M Thandavaram, A Sehar, A Waseem, H Siddiqui, T Dahiya, DS Patel, P Tillmann, H AF Ali, Hassam Shahzil, Muhammad Moond, Vishali Shahzad, Maria Thandavaram, Abhay Sehar, Alina Waseem, Haniya Siddiqui, Taha Dahiya, Dushyant Singh Patel, Pratik Tillmann, Hans TI Non-Pharmacological Approach to Diet and Exercise in Metabolic-Associated Fatty Liver Disease: Bridging the Gap between Research and Clinical Practice SO JOURNAL OF PERSONALIZED MEDICINE LA English DT Review DE metabolic-associated fatty liver disease (MASLD); nonalcoholic fatty liver disease; coffee; diet; ketogenic; intermittent fasting; resistance training ID CALORIE-KETOGENIC DIET; HEPATITIS-B-VIRUS; INSULIN-RESISTANCE; ADIPOSE-TISSUE; DOUBLE-BLIND; LIFE-STYLE; VITAMIN-E; STEATOSIS; NAFLD; PATHOGENESIS AB This review provides a practical and comprehensive overview of non-pharmacological interventions for metabolic-associated fatty liver disease (MASLD), focusing on dietary and exercise strategies. It highlights the effectiveness of coffee consumption, intermittent fasting, and Mediterranean and ketogenic diets in improving metabolic and liver health. The review emphasizes the importance of combining aerobic and resistance training as a critical approach to reducing liver fat and increasing insulin sensitivity. Additionally, it discusses the synergy between diet and exercise in enhancing liver parameters and the role of gut microbiota in MASLD. The paper underscores the need for a holistic, individualized approach, integrating diet, exercise, gut health, and patient motivation. It also highlights the long-term benefits and minimal risks of lifestyle interventions compared to the side effects of pharmacological and surgical options. The review calls for personalized treatment strategies, continuous patient education, and further research to optimize therapeutic outcomes in MASLD management. C1 [Ali, Hassam; Tillmann, Hans] Brody Sch Med, ECU Hlth Med Ctr, Dept Gastroenterol Hepatol & Nutr, Greenville, NC 27834 USA. [Ali, Hassam] East Carolina Univ, Div Gastroenterol Hepatol & Nutr, Greenville, NC 27834 USA. [Shahzil, Muhammad] Weiss Mem Hosp, Dept Internal Med, Chicago, IL 60640 USA. [Moond, Vishali] Univ Med & Dent New Jersey, St Peters Univ Hosp, Dept Internal Med, New Brunswick, NJ 08901 USA. [Shahzad, Maria] Albert Einstein Coll Med, Jacobi Med Ctr, Dept Internal Med, Bronx, NY 10461 USA. [Thandavaram, Abhay] Kamineni Acad Med Sci & Res Ctr, Dept Internal Med, Hyderabad 500068, Telangana, India. [Sehar, Alina] Univ Alabama Birmingham, Dept Internal Med, Huntsville Campus, Huntsville, AL 35801 USA. [Waseem, Haniya] Advent Hlth Tampa, Dept Internal Med, Tampa, FL 33613 USA. [Siddiqui, Taha] Hofstra Univ, Mather Hosp, Zucker Sch Med, Dept Internal Med, Port Jefferson, NY 11777 USA. [Dahiya, Dushyant Singh] Univ Kansas, Div Gastroenterol Hepatol & Motil, Sch Med, Kansas City, KS 66103 USA. [Patel, Pratik] Hofstra Univ, Zucker Sch Med, Mather Hosp, Dept Gastroenterol, Port Jefferson, NY 11777 USA. C3 University of North Carolina; East Carolina University; Rutgers University System; Rutgers University New Brunswick; Rutgers University Biomedical & Health Sciences; Saint Peter's University Hospital; Yeshiva University; Montefiore Medical Center; Albert Einstein College of Medicine; Jacobi Medical Center; University of Alabama System; University of Alabama Birmingham; Adventist Health Services; AdventHealth; (AdventHealth) West Florida Division; West Florida Hospital; AdventHealth Tampa; Northwell Health; Hofstra University; University of Kansas; University of Kansas Medical Center; Hofstra University; Northwell Health RP Ali, H (通讯作者)，Brody Sch Med, ECU Hlth Med Ctr, Dept Gastroenterol Hepatol & Nutr, Greenville, NC 27834 USA.; Ali, H (通讯作者)，East Carolina Univ, Div Gastroenterol Hepatol & Nutr, Greenville, NC 27834 USA. 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Pers. Med. PD JAN PY 2024 VL 14 IS 1 AR 61 DI 10.3390/jpm14010061 PG 27 WC Health Care Sciences & Services; Medicine, General & Internal WE Science Citation Index Expanded (SCI-EXPANDED) SC Health Care Sciences & Services; General & Internal Medicine GA GD8J3 UT WOS:001150816500001 PM 38248762 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Moss, K Gitman, V Sanchez, MIP Oczkowski, S Armstrong, D Jayakumar, S Karvellas, CJ Selzner, N Dionne, J AF Moss, Kasey Gitman, Victor Sanchez, M. Ines Pinto Oczkowski, Simon Armstrong, David Jayakumar, Saumya Karvellas, Constantine Jason Selzner, Nazia Dionne, Joanna TI Evidence related to a vegetarian diet and metabolic dysfunction-associated steatotic liver disease: protocol for a scoping review SO BMJ OPEN LA English DT Review DE Gastroenterology; NUTRITION & DIETETICS; Hepatology; Obesity ID HEPATIC STEATOSIS; INDIVIDUALS; PREVALENCE; RISK AB Introduction Metabolic dysfunction-associated fatty liver disease (MASLD) is the hepatic manifestation of metabolic syndrome and the leading cause of chronic liver disease worldwide. Given that there is no pharmacological treatment for MASLD, it is imperative to understand whether lifestyle modifications may improve biochemical and pathological outcomes. One commonly proposed dietary modification is the Mediterranean diet; however, vegetarianism may also be a promising intervention. Vegetarianism has been shown to be associated with reduced morbidity and mortality in metabolic syndrome outcomes in coronary artery disease and diabetes; however, the relationship between vegetarian diet and MASLD is less clear. In this scoping review, we will provide a comprehensive overview of the current body of evidence related to a vegetarian diet and MASLD. Methods and analysis The aim of this scoping review is to describe and summarise the current body of evidence related to MASLD and a vegetarian diet. This review will be conducted using Arksey and O'Malley's framework. The literature review will be conducted using the following databases: SCOPUS, Web of Science, CINAHL-Plus, Cochrane Library and Medline. No restriction will be made on publication date. Included studies will encompass clinical trials and observational designs that examine effects or association of vegetarian diet in adults (>= 16 years) and report on the incidence, prevalence or progression of MASLD. Grey literature, non-human studies and articles focusing on changes in a specific food or nutraceutical will be excluded. Articles must have an English-language abstract available to be considered for inclusion. Screening and data extraction will be conducted by two independent reviewers. The findings will be summarised with descriptive statistics. Ethics and dissemination Approval from a medical ethics committee is not required for this review. Once the review is complete, the findings will be submitted to a peer-reviewed journal. C1 [Moss, Kasey; Oczkowski, Simon] McMaster Univ, Dept Med, Hamilton, ON, Canada. [Gitman, Victor] Univ Waterloo, Sch Pharm, Waterloo, ON, Canada. [Sanchez, M. Ines Pinto] McMaster Univ, Div Gastroenterol, Dept Med, Hamilton, ON, Canada. [Sanchez, M. Ines Pinto; Armstrong, David] McMaster Univ, Farncombe Family Digest Hlth Res Inst, Hamilton, ON, Canada. [Oczkowski, Simon] McMaster Univ, Dept Hlth Res Methods Evidence & Impact, Hamilton, ON, Canada. [Armstrong, David] McMaster Univ, Div Gastroenterol, Dept Med, Hamilton, ON, Canada. [Jayakumar, Saumya] Univ British Columbia, Div Gastroenterol, Dept Med, Vancouver, BC, Canada. [Jayakumar, Saumya; Karvellas, Constantine Jason] Univ Alberta, Dept Med, Div Gastroenterol, Edmonton, AB, Canada. [Selzner, Nazia] Univ Toronto, Dept Med, Div Gastroenterol, Toronto, ON, Canada. [Dionne, Joanna] McMaster Univ, Dept Hlth Res Methods Evidence & Impact, Dept Med, Hamilton, ON, Canada. [Dionne, Joanna] McMaster Univ, Farncombe Family Digest Hlth Res Inst, Dept Med, Hamilton, ON, Canada. C3 McMaster University; University of Waterloo; McMaster University; McMaster University; McMaster University; McMaster University; University of British Columbia; University of Alberta; University of Toronto; McMaster University; McMaster University RP Moss, K (通讯作者)，McMaster Univ, Dept Med, Hamilton, ON, Canada. EM kasey.moss@medportal.ca RI Selzner, Nazia/AAI-1469-2020; Oczkowski, Simon/AAL-6833-2020; Pinto-Sanchez, Maria Ines/P-1626-2016; Dionne, Joanna/X-1720-2018 OI Oczkowski, Simon/0000-0002-2874-8948; , Kasey/0000-0002-5468-1476; Pinto-Sanchez, Maria Ines/0000-0002-9040-9824; Gitman, Victor/0009-0001-4236-0114; Dionne, Joanna/0000-0002-9401-6868; Karvellas, Constantine/0000-0002-1555-1089 CR [Anonymous], Vegetarianism is on the rise - especially the part-time kind - the hill [Anonymous], What percentage of Americans are vegetarian? 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Despite the lack of approved pharmacological treatments, dietary interventions with plant-based foods, including the Mediterranean diet (MED), rich in numerous bioactive compounds may offer benefits for metabolic health and hepatic function. However, the role of individual plant foods in MASLD management remains unclear. Objectives: This review investigates the effects of specific plant-based foods, consumed as part of the MED and Dietary Approaches to Stop Hypertension (DASHs) diet, on metabolic outcomes, including hepatic function, in MASLD patients alone or in combination with comorbidities such as obesity, metabolic syndrome, and type 2 diabetes mellitus (T2DM). Methods: A systematic search was registered and conducted across nine databases to identify randomized controlled trials (RCTs) carried out in adults with MASLD and published between January 2020 and May 2025, following PRISMA guidelines. Results: Plant-based interventions including oranges, whole-grain products (WGPs), high-fiber buns (HFBs), beetroot juice (BJ), garlic, ginger, flaxseed, spirulina, rapeseed oil, sour tea, and green coffee extract (GCE) demonstrated mixed effects on metabolic and hepatic outcomes. GCE, flaxseed, and rapeseed oil improved anthropometric measures, while sour tea and ginger supported blood pressure control. WGPs, GCE, flaxseed, rapeseed oil, spirulina, ginger, and garlic were beneficial for glycemic regulation, whereas WGPs, HFBs, BJ, golden flaxseed, rapeseed oil, and garlic improved lipid profiles. Liver enzymes improved following consumption of WGPs, BJ, sour tea, flaxseed oil, and garlic, and hepatic steatosis was reduced after intake of oranges, WGPs, HFBs, BJ, flaxseed powder, rapeseed oil, and garlic powder. Conversely, a solely fruit-rich diet (FRD) had negative effects across all outcomes. Conclusions: Plant-based foods improved metabolic outcomes, with WGPs, HFBs, beetroot, oranges, sour tea, flaxseed oil, and garlic providing specific benefits for liver health. Further research is needed to validate these effects and ensure their safety in MASLD management. C1 [Jurek, Joanna Michalina; Clavero Mestres, Helena; Auguet, Teresa] Univ Rovira i Virgili, Inst Invest Sanitaria Pere Virgili, Dept Med Cirurgia i Cirurgia, Grup Recerca GEMMAIR AGAUR Med Aplicada URV, Mallafre Guasch 4, Tarragona 43007, Spain. [Zablocka-Slowinska, Katarzyna] WSB Merito Univ Wroclaw, Fac Finance & Management, Fabryczna 29-31, PL-53609 Wroclaw, Poland. [Pieczynska, Joanna] Wroclaw Med Univ, Dept Dietet & Bromatol, Borowska 211, PL-50556 Wroclaw, Poland. [Auguet, Teresa] Hosp Univ Tarragona Joan XXIII, Serv Med Interna, Mallafre Guasch 4, Tarragona 43007, Spain. C3 Universitat Rovira i Virgili; Institut d'Investigacio Sanitaria Pere Virgili (IISPV); Wroclaw Medical University; Universitat Rovira i Virgili; Hospital Universitari De Tarragona Joan XXIII RP Auguet, T (通讯作者)，Univ Rovira i Virgili, Inst Invest Sanitaria Pere Virgili, Dept Med Cirurgia i Cirurgia, Grup Recerca GEMMAIR AGAUR Med Aplicada URV, Mallafre Guasch 4, Tarragona 43007, Spain.; Auguet, T (通讯作者)，Hosp Univ Tarragona Joan XXIII, Serv Med Interna, Mallafre Guasch 4, Tarragona 43007, Spain. EM joanna.michalina.jurek@gmail.com; katarzyna.zablocka-slowinska@wroclaw.merito.pl; joanna.pieczynska@umw.edu.pl; tauguet.hj23.ics@gencat.cat RI Zabłocka-Słowińska, Katarzyna/AAG-3233-2019; Pieczyńska, Joanna/S-5027-2019; Auguet, Teresa/AAC-5838-2020 OI Clavero Mestres, Helena/0009-0004-0001-1866; Jurek, Joanna Michalina/0000-0002-7319-0672; Auguet, Teresa/0000-0003-0396-6428 FU Agencia de Gestio d'Ajuts Universitaris de Recerca [AGAUR-2021-SGR-00030]; INVESTIGO Program from the URV; AGAUR; Plan de Recuperacion, Transformacion y Resiliencia [2023POST-INV-10]; Marti Franques d'Ajuts a la Investigacio Program from the URV [2023PMF-PIPF-17] FX This study was supported by funds from Agencia de Gestio d'Ajuts Universitaris de Recerca (AGAUR-2021-SGR-00030 to Teresa Auguet), by the INVESTIGO Program from the URV, AGAUR and Plan de Recuperacion, Transformacion y Resiliencia (2023POST-INV-10 to Teresa Auguet), and by the Marti Franques d'Ajuts a la Investigacio Program from the URV (2023PMF-PIPF-17). 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It is currently one of the most prevalent liver diseases and one of the world's important public health problems. At present, there is no consensus on a pharmacological treatment for MAFLD. By contrast, lifestyle interventions based on exercise and a balanced diet are considered to be the cornerstone of MAFLD management. Mediterranean diet (MD) have a large content of polyphenols, polyunsaturated fatty acids, oleic acid, carotenoids and fiber, which carry out antioxidant, anti-inflammatory and antibacterial benefits. It has been considered to reduce the incidence rate of cardiovascular disease and type 2 diabetes. The purpose of this narrative review is therefore to summarize and analyze the evidence for the effect of MD on metabolic outcomes in MAFLD patients. C1 [Xiao, Yuji; Zhang, Xue; Yi, Dongxin; Qiu, Fangyi] Dalian Med Univ, Sch Publ Hlth, Dalian, Liaoning, Peoples R China. [Xiao, Yuji] Chongqing Med Univ, Bishan Hosp, Chongqing, Peoples R China. [Zhang, Xue] Second Peoples Hosp Dalian, Dept Cardiol, Dalian, Liaoning, Peoples R China. [Wu, Lei] Beijing Inst Radiat Med, Beijing Key Lab Radiobiol, Dept Radiobiol, Beijing, Peoples R China. [Tang, Yiyong] Dalian Med Univ, Affiliated Hosp 2, Dept Cardiovasc Ultrasound, Dalian, Liaoning, Peoples R China. [Wang, Ningning] Dalian Med Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Dalian, Liaoning, Peoples R China. [Wang, Ningning] Dalian Med Univ, Global Hlth Res Ctr, Dalian, Liaoning, Peoples R China. C3 Dalian Medical University; Chongqing Medical University; Dalian Medical University; Dalian Medical University; Dalian Medical University RP Tang, YY (通讯作者)，Dalian Med Univ, Affiliated Hosp 2, Dept Cardiovasc Ultrasound, Dalian, Liaoning, Peoples R China.; Wang, NN (通讯作者)，Dalian Med Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Dalian, Liaoning, Peoples R China.; Wang, NN (通讯作者)，Dalian Med Univ, Global Hlth Res Ctr, Dalian, Liaoning, Peoples R China. EM tyydyfs2y@163.com; zkxwnn@dmu.edu.cn FU This work is supported by National Natural Science Foundation of China (grant no. 82003476, to NW). [82003476]; National Natural Science Foundation of China FX This work is supported by National Natural Science Foundation of China (grant no. 82003476, to NW). 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Nutr. PD OCT 10 PY 2023 VL 10 AR 1225946 DI 10.3389/fnut.2023.1225946 PG 7 WC Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Nutrition & Dietetics GA U9IK5 UT WOS:001087865600001 PM 37899839 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Castellanos-Tapia, L Tejero-Barrera, ME Salas-Silva, S Simoni-Nieves, A Escobedo-Calvario, A Gomez-Quiroz, LE AF Castellanos-Tapia, Lyssia Elizabeth Tejero-Barrera, Maria Salas-Silva, Soraya Simoni-Nieves, Arturo Escobedo-Calvario, Alejandro Gomez-Quiroz, Luis E. TI Mediterranean-like mix of fatty acids induces cellular protection on lipid-overloaded hepatocytes from western diet fed mice SO ANNALS OF HEPATOLOGY LA English DT Article DE PUFA; MUFA; Mediterranean diet; Western diet; NAFLD ID SENSITIZES; DAMAGE; STEATOSIS; DISEASE; CELLS AB Introduction and objective. Non-alcoholic fatty liver disease remains as one of the main liver disorders worldwide. It is widely accepted that is the kind of lipid, rather than the amount deposited in the cells that determines cell damage. Cholesterol and saturated free fatty acids are deleterious lipids when accumulated but, in contrast, there are some valuable lipids that could counteract those with harmful properties. Much of this knowledge arises from studies using a single fatty acid, but the effects of a combination of fatty acids, as obtained by diet has been poorly addressed. In the present work, we were focused to figure out the cellular effect of two different mixes of fatty acids, one with high proportion of saturated fatty acids, and another one with high proportion of unsaturated fatty acids (Mediterranean-like) in a cellular model of steatosis. Material and methods. Primary mouse hepatocytes from animals fed with a western diet (high fat and carbohydrates diet), were treated with both mixes of fatty acids for 24 h. Results. Our data clearly show that only the high unsaturated fatty acid mix induced a decrease in triglycerides (47.5%) and cholesterol (59%) content in steatotic hepatocytes mediating cellular protection associated to the decrement of ROS and oxidative damage. The mixture of high saturated fatty acids exhibited no effects, preserving high levels of cholesterol and triglycerides and oxidative damage. In conclusion, our results show that Mediterranean-like mix of fatty acids exerts cellular protection in steatosis by decreasing triglycerides, cholesterol, ROS content and oxidative damage. (C) 2020 Fundacion Clinica Medica Sur, A.C. Published by Elsevier Espana, S.L.U. C1 [Castellanos-Tapia, Lyssia; Elizabeth Tejero-Barrera, Maria] Natl Inst Genom Med, Nutrigen Lab, Mexico City, DF, Mexico. [Castellanos-Tapia, Lyssia; Salas-Silva, Soraya; Simoni-Nieves, Arturo; Escobedo-Calvario, Alejandro] Univ Autonoma Metropolitana Unidad Iztapalapa, Posgrad Biol Expt, DCBS, Mexico City, DF, Mexico. [Salas-Silva, Soraya; Simoni-Nieves, Arturo; Escobedo-Calvario, Alejandro; Gomez-Quiroz, Luis E.] Univ Autonoma Metropolitana Iztapalapa, Dept Ciencias Salud, Mexico City, DF, Mexico. C3 Instituto Nacional de Medicina Genomica; Universidad Autonoma Metropolitana - Mexico; Universidad Autonoma Metropolitana - Mexico RP Gomez-Quiroz, LE (通讯作者)，Univ Autonoma Metropolitana Iztapalapa, Dept Ciencias Salud, Mexico City, DF, Mexico. EM legq@xanum.uam.mx RI Simoni-Nieves, Arturo/IUO-7915-2023; Tejero, Maria Elizabeth/MBV-3355-2025; Castellanos, Lyss/AAQ-6968-2021; Gomez-Quiroz, Luis/L-8415-2013 OI Simoni-Nieves, Arturo/0000-0002-1353-260X; Tejero, Maria Elizabeth/0000-0001-5611-2309; FU National Institute of Genomic Medicine FX This work was supported by National Institute of Genomic Medicine. Catedra Nestle-INMEGEN, CONACYT: Fronteras de la Ciencia 1320 and CB-252942. Universidad Autonoma Metropolitana Unidad Iztapalapa. CR Abenavoli L, 2019, INT J ENV RES PUB HE, V16, DOI 10.3390/ijerph16173011 Abenavoli L, 2019, EXPERT REV GASTROENT, V13, P739, DOI 10.1080/17474124.2019.1634544 Albracht-Schulte K, 2019, NUTRIENTS, V11, DOI 10.3390/nu11030599 Angulo P, 2002, NEW ENGL J MED, V346, P1221, DOI 10.1038/nrdp.2015.80 Batis C, 2011, J NUTR, V141, P1898, DOI 10.3945/jn.111.141473 Bechynska K, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-54225-8 Bullón-Vela V, 2020, NUTRITION, V71, DOI 10.1016/j.nut.2019.110620 Chiappini F, 2017, SCI REP-UK, V7, DOI 10.1038/srep46658 Costa CS, 2018, PUBLIC HEALTH NUTR, V21, P148, DOI 10.1017/S1368980017001331 Domínguez-Pérez M, 2019, J CELL PHYSIOL, V234, P7213, DOI 10.1002/jcp.27474 Enríquez-Cortina C, 2017, ONCOTARGET, V8, P104136, DOI 10.18632/oncotarget.22024 Gerardo-Ramírez M, 2019, BBA-MOL BASIS DIS, V1865, P1540, DOI 10.1016/j.bbadis.2019.03.003 Gomez-Quiroz LE, 2008, J BIOL CHEM, V283, P14581, DOI 10.1074/jbc.M707733200 Gomez-Quiroz LE, 2016, TOXICOLOGY, V361, P39, DOI 10.1016/j.tox.2016.07.004 Hara T, 2013, REV PHYSIOL BIOCH P, V164, P77, DOI 10.1007/112_2013_13 Henley SJ, 2020, CANCER-AM CANCER SOC, V126, P2225, DOI [10.1002/cncr.32802, 10.1002/cncr.31551] Hernández I, 2015, FOOD CHEM TOXICOL, V76, P109, DOI 10.1016/j.fct.2014.12.005 Hodson L, 2014, J NUTR, V144, P33, DOI 10.3945/jn.113.183749 Jenab M, 2009, HUM GENET, V125, P507, DOI 10.1007/s00439-009-0662-5 Jung UJ, 2011, BBA-MOL CELL BIOL L, V1811, P491, DOI 10.1016/j.bbalip.2011.06.003 Kang S, 2018, BBA-MOL CELL BIOL L, V1863, P105, DOI 10.1016/j.bbalip.2017.11.002 López-Islas A, 2016, OXID MED CELL LONGEV, V2016, DOI 10.1155/2016/9209825 López-Reyes A, 2018, ANN HEPATOL, V17, P857, DOI 10.5604/01.3001.0012.3160 Marí M, 2006, CELL METAB, V4, P185, DOI 10.1016/j.cmet.2006.07.006 Moosavian SP, 2020, CLIN NUTR ESPEN, V35, P40, DOI 10.1016/j.clnesp.2019.10.008 Mozaffarian D, 2011, NEW ENGL J MED, V364, P2392, DOI 10.1056/NEJMoa1014296 Najbjerg H, 2013, J BIOPHOTONICS, V6, P446, DOI 10.1002/jbio.201200073 Nuño-Lámbarri N, 2016, OXID MED CELL LONGEV, V2016, DOI 10.1155/2016/9895176 Perumpail BJ, 2017, WORLD J GASTROENTERO, V23, P8263, DOI 10.3748/wjg.v23.i47.8263 Saadatian-Elahi M, 2009, AM J CLIN NUTR, V89, P331, DOI 10.3945/ajcn.2008.26834 Salas-Silva S, 2020, BIOCHEM PHARMACOL, V174, DOI 10.1016/j.bcp.2020.113812 Sofi F, 2010, AM J CLIN NUTR, V92, P1189, DOI 10.3945/ajcn.2010.29673 Sofi F, 2010, J ALZHEIMERS DIS, V20, P795, DOI 10.3233/JAD-2010-1418 Spengler EK, 2015, MAYO CLIN PROC, V90, P1233, DOI 10.1016/j.mayocp.2015.06.013 Trichopoulou A, 2014, BMC MED, V12, DOI 10.1186/1741-7015-12-112 Valenzuela R, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0046400 Yamada K, 2015, LIVER INT, V35, P582, DOI 10.1111/liv.12685 Zeng X, 2020, NUTR METAB, V17, DOI 10.1186/s12986-020-0434-8 NR 38 TC 3 Z9 5 U1 0 U2 2 PU ELSEVIER ESPANA PI MADRID PA CALLE DE ZURBANO, 76-4TH FLR LEFT, MADRID, 28010, SPAIN SN 1665-2681 J9 ANN HEPATOL JI Ann. Hepatol. PD SEP-OCT PY 2020 VL 19 IS 5 BP 489 EP 496 DI 10.1016/j.aohep.2020.06.005 PG 8 WC Gastroenterology & Hepatology WE Science Citation Index Expanded (SCI-EXPANDED) SC Gastroenterology & Hepatology GA OA0QP UT WOS:000577501700007 PM 32663612 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Scoppola, V Crudele, A Mosca, A Panera, N di Camillo, C Bock, C Raponi, M Villani, A Alisi, A Valentini, D AF Scoppola, Vittorio Crudele, Annalisa Mosca, Antonella Panera, Nadia di Camillo, Chiara Bock, Caterina Raponi, Massimiliano Villani, Alberto Alisi, Anna Valentini, Diletta TI Lifestyle Intervention Improves Metabolic Dysfunction-Associated Steatotic Liver Disease in Children with Down Syndrome SO NUTRIENTS LA English DT Article DE down syndrome; MASLD; antioxidants; mediterranean diet; cytokines ID MEDITERRANEAN DIET; SYNDROME-PREVALENCE; OXIDATIVE STRESS; ITALIAN CHILDREN; VITAMIN-E; OBESITY; ADOLESCENTS; MANAGEMENT; ADHERENCE; NASH AB Background/Objectives: We evaluated the efficacy of a good lifestyle intervention on the severity of metabolic dysfunction-associated steatotic liver disease (MASLD) in children with Down syndrome (DS). Methods: This retrospective longitudinal study included 31 children with Down syndrome (DS) who were affected by MASLD and attended nutritional counseling based on a nutritional approach (e.g., Mediterranean diet and antioxidant supplements), as well as physical exercise. Clinical parameters, markers of low-grade systemic inflammation, and hepatic steatosis, as assessed by ultrasound, were evaluated at baseline (T0) and after 6 months (T1). Results: Several anthropometric and biochemical parameters, including body mass index, waist circumference, diastolic and systolic blood pressure, aspartate aminotransferase, basal insulin, insulin resistance, pro-inflammatory interleukin-1 beta, and anti-inflammatory interleukin-10, showed significant improvement after 6 months of a nutritional approach. This study also found a regression of at least one grade of hepatic steatosis in a significant portion of patients, especially in those who received antioxidant supplements. Conclusions: Our study further supports the hypothesis that a healthy lifestyle intervention, based on adherence to the Mediterranean diet, natural supplements with antioxidant properties, and regular physical activity, can be considered a safe therapeutic approach for reducing the risk and severity of MASLD in children with DS. C1 [Scoppola, Vittorio; Crudele, Annalisa; Panera, Nadia; Alisi, Anna] Bambino Gesu Pediat Hosp, Res Unit Genet Complex Phenotypes, IRCCS, I-00165 Rome, Italy. [Mosca, Antonella] Bambino Gesu Pediat Hosp, Hepatol & Liver Transplant Unit, IRCCS, I-00165 Rome, Italy. [di Camillo, Chiara; Villani, Alberto] Bambino Gesu Pediat Hosp, Gen Pediat & ED Level Unit 2, IRCCS, I-00165 Rome, Italy. [Bock, Caterina] Bambino Gesu Pediat Hosp, Diagnost & Intervent Radiol Unit, IRCCS, I-00165 Rome, Italy. [Raponi, Massimiliano] Bambino Gesu Pediat Hosp, Med Direct, IRCCS, I-00165 Rome, Italy. [Valentini, Diletta] Bambino Gesu Pediat Hosp, Gen Pediat Folllow Up Unit, IRCCS, I-00165 Rome, Italy. C3 IRCCS Bambino Gesu; IRCCS Bambino Gesu; IRCCS Bambino Gesu; IRCCS Bambino Gesu; IRCCS Bambino Gesu; IRCCS Bambino Gesu RP Alisi, A (通讯作者)，Bambino Gesu Pediat Hosp, Res Unit Genet Complex Phenotypes, IRCCS, I-00165 Rome, Italy. EM vittorio.scoppola@opbg.net; annalisa.crudele@gmail.com; antonella.mosca@opbg.net; nadia.panera@opbg.net; chiara.dicamillo@opbg.net; caterina.bock@opbg.net; massimiliano.raponi@opbg.net; alberto.villani@opbg.net; anna.alisi@opbg.net; diletta.valentini@opbg.net RI panera, nadia/I-2087-2018; Mosca, Antonella/JTS-6893-2023; Crudele, Annalisa/I-2162-2018; Alisi, Anna/A-6469-2010; Valentini, Diletta/AAA-2463-2020; VILLANI, ALBERTO/K-9844-2018 OI Mosca, Antonella/0000-0001-9646-7462; Valentini, Diletta/0000-0003-0378-4499; VILLANI, ALBERTO/0000-0002-9120-0424 FU Italian Ministry of Health; Italian Ministry of Health with "Current Research funds; Fondazione Veronesi" 2021 fellowship program FX This research was funded by the Italian Ministry of Health with "Current Research funds" to Anna Alisi. During the study Nadia Panera was supported by "Fondazione Veronesi" 2021 fellowship program. 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Martinez, J. Alfredo TI Alcohol Drinking Impacts on Adiposity and Steatotic Liver Disease: Concurrent Effects on Metabolic Pathways and Cardiovascular Risks SO CURRENT OBESITY REPORTS LA English DT Review DE Alcohol intake; MASLD; Cardiovascular diseases; Fat distribution; Precision medicine; Epidemiological studies ID CORONARY-HEART-DISEASE; MEDITERRANEAN DIET; BODY-COMPOSITION; NATIONAL-HEALTH; CONSUMPTION; OBESITY; MORTALITY; PATTERNS; ADULTS; PERSPECTIVES AB Purpose of ReviewThis integrative search aimed to provide a scoping overview of the relationships between the benefits and harms of alcohol drinking with cardiovascular events as associated to body fat mass and fatty liver diseases, as well as offering critical insights for precision nutrition research and personalized medicine implementation concerning cardiovascular risk management associated to ethanol consumption.Recent FindingsFrequent alcohol intake could contribute to a sustained rise in adiposity over time. Body fat distribution patterns (abdominal/gluteus-femoral) and intrahepatic accumulation of lipids have been linked to adverse cardiovascular clinical outcomes depending on ethanol intake. Therefore, there is a need to understand the complex interplay between alcohol consumption, adipose store distribution, metabolic dysfunction-associated steatotic liver disease (MASLD), and cardiovascular events in adult individuals. The current narrative review deals with underconsidered and apparently conflicting benefits concerning the amount of alcohol intake, ranging from abstention to moderation, and highlights the requirements for additional robust methodological studies and trials to interpret undertrained and existing controversies.SummaryThe conclusion of this review emphasizes the need of newer multifaceted clinical approaches for precision medicine implementation, considering epidemiological strategies and pathophysiological mechanistic. Newer investigations and trials should be derived and performed particularly focusing both on alcohol's objective consequences as putatively mediated by fat deposition, including associated roles in fatty liver disease as well as to differentiate the impact of different levels of alcohol consumption (absence or moderation) concerning cardiovascular risks and accompanying clinical manifestations. Indeed, the threshold for the safe consumption of alcoholic drinks remains to be fully elucidated. C1 [Martinez-Urbistondo, Diego] Clin Univ Navarra, Med Interna, Madrid, Spain. [Perez-Diaz-del-Campo, Nuria] Univ Turin, Dept Med Sci, Turin, Italy. [Landecho, Manuel F.] Clin Univ Navarra, Dept Internal Med, Gen Hlth Check Up Unit, Pamplona, Spain. [Martinez, J. Alfredo] Inst Salud Carlos III, Biomed Res Networking Ctr Physiopathol Obes & Nutr, Madrid, Spain. [Martinez, J. Alfredo] UAM, Res Inst Food & Hlth Sci IMDEA Food, Precis Nutr Program, CSIC, Madrid, Spain. [Martinez, J. Alfredo] Univ Valladolid, Ctr Med & Endocrinol, Valladolid, Spain. C3 University of Navarra; University of Turin; University of Navarra; Instituto de Salud Carlos III; Autonomous University of Madrid; IMDEA Food Institute; Consejo Superior de Investigaciones Cientificas (CSIC); Universidad de Valladolid RP Martínez, JA (通讯作者)，Inst Salud Carlos III, Biomed Res Networking Ctr Physiopathol Obes & Nutr, Madrid, Spain.; Martínez, JA (通讯作者)，UAM, Res Inst Food & Hlth Sci IMDEA Food, Precis Nutr Program, CSIC, Madrid, Spain.; Martínez, JA (通讯作者)，Univ Valladolid, Ctr Med & Endocrinol, Valladolid, Spain. EM jalfredo.martinez@imdea.org RI Landecho, Manuel/D-9227-2013; Martínez, J./K-8709-2014; Pérez Díaz del Campo, Nuria/HGC-4070-2022 OI Pérez Díaz del Campo, Nuria/0000-0003-0479-8825; Martínez-Urbistondo, Diego/0000-0002-0530-7349 FU CRUE-CSIC agreement; Springer Nature FX Open Access funding provided thanks to the CRUE-CSIC agreement with Springer Nature. 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Obes. Rep. PD SEP PY 2024 VL 13 IS 3 BP 461 EP 474 DI 10.1007/s13679-024-00560-5 EA MAR 2024 PG 14 WC Endocrinology & Metabolism; Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Endocrinology & Metabolism; Nutrition & Dietetics GA C0N6Z UT WOS:001190157900001 PM 38520634 OA Green Submitted, hybrid DA 2026-02-02 ER PT J AU Abenavoli, L Gambardella, ML Scarlata, GGM Lenci, I Baiocchi, L Luzza, F AF Abenavoli, Ludovico Gambardella, Maria Luisa Scarlata, Giuseppe Guido Maria Lenci, Ilaria Baiocchi, Leonardo Luzza, Francesco TI The Many Faces of Metabolic Dysfunction-Associated Fatty Liver Disease Treatment: From the Mediterranean Diet to Fecal Microbiota Transplantation SO MEDICINA-LITHUANIA LA English DT Review DE steatosis; probiotics; gut-liver axis; leaky gut; Mediterranean diet ID GUT MICROBIOTA; PROBIOTICS; OBESITY; INDEX; MASS AB The gastrointestinal tract is inhabited by the gut microbiota. The main phyla are Firmicutes and Bacteroidetes. In non-alcoholic fatty liver disease, now renamed metabolic dysfunction-associated fatty liver disease (MAFLD), an alteration in Firmicutes and Bacteroidetes abundance promotes its pathogenesis and evolution into non-alcoholic steatohepatitis, liver cirrhosis, and hepatocellular carcinoma. For this reason, early treatment is necessary to counteract its progression. The aim of the present narrative review is to evaluate the different therapeutic approaches to MAFLD. The most important treatment for MAFLD is lifestyle changes. In this regard, the Mediterranean diet could be considered the gold standard in the prevention and treatment of MAFLD. In contrast, a Western diet should be discouraged. Probiotics and fecal microbiota transplantation seem to be valid, safe, and effective alternatives for MAFLD treatment. However, more studies with a longer follow-up and with a larger cohort of patients are needed to underline the more effective approaches to contrasting MAFLD. C1 [Abenavoli, Ludovico; Gambardella, Maria Luisa; Scarlata, Giuseppe Guido Maria; Luzza, Francesco] Magna Graecia Univ Catanzaro, Dept Hlth Sci, Viale Europa, I-88100 Catanzaro, Italy. [Lenci, Ilaria; Baiocchi, Leonardo] Univ Tor Vergata, Hepatol & Liver Transplant Unit, Via Montpellier, I-00133 Rome, Italy. C3 Magna Graecia University of Catanzaro; University of Rome Tor Vergata RP Abenavoli, L (通讯作者)，Magna Graecia Univ Catanzaro, Dept Hlth Sci, Viale Europa, I-88100 Catanzaro, Italy. EM l.abenavoli@unicz.it; marialuisa.gambardella@studenti.unicz.it; giuseppeguidomaria.scarlata@unicz.it; ilaria.lenci@uniroma2.it; baiocchi@uniroma2.it; luzza@unicz.it RI MONTEBIANCO ABENAVOLI, Ludovico/J-4394-2019; Scarlata, Giuseppe Guido Maria/IQV-1440-2023 OI MONTEBIANCO ABENAVOLI, Ludovico/0000-0002-5922-1524; LENCI, Ilaria/0000-0001-5704-9890; Scarlata, Giuseppe Guido Maria/0000-0002-7084-8264; Luzza, Francesco/0000-0001-5120-1046 CR Abenavoli L, 2024, MINERVA GASTROENTERO, V70, P430, DOI 10.23736/S2724-5985.23.03590-8 Abenavoli L, 2023, MEDICINA-LITHUANIA, V59, DOI 10.3390/medicina59111935 Abenavoli L, 2023, MEDICINA-LITHUANIA, V59, DOI 10.3390/medicina59030594 Abenavoli L, 2022, MEDICINA-LITHUANIA, V58, DOI 10.3390/medicina58111559 Abenavoli L, 2017, NUTRIENTS, V9, DOI 10.3390/nu9080870 Albillos A, 2020, J HEPATOL, V72, P558, DOI 10.1016/j.jhep.2019.10.003 Allegretti JR, 2019, LANCET, V394, P420, DOI 10.1016/S0140-6736(19)31266-8 Aller R, 2011, EUR REV MED PHARMACO, V15, P1090 Anh SB, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-42059-3 Aron-Wisnewsky J, 2020, NAT REV GASTRO HEPAT, V17, P279, DOI 10.1038/s41575-020-0269-9 Barbouti A, 2021, ANTIOXIDANTS-BASEL, V10, DOI 10.3390/antiox10081213 Basson AR, 2020, TRANSL RES, V226, P1, DOI 10.1016/j.trsl.2020.05.008 Boicean A, 2023, BIOMEDICINES, V11, DOI 10.3390/biomedicines11112930 Boicean A, 2023, BIOMEDICINES, V11, DOI 10.3390/biomedicines11072058 Boicean A, 2023, BIOMEDICINES, V11, DOI 10.3390/biomedicines11041016 Cao CJ, 2023, FRONT NUTR, V10, DOI 10.3389/fnut.2023.1155306 Carding Simon, 2015, Microbial Ecology in Health and Disease, V26, P26191, DOI 10.3402/mehd.v26.26191 Clemente-Suárez VJ, 2023, NUTRIENTS, V15, DOI 10.3390/nu15122749 Craven L, 2020, AM J GASTROENTEROL, V115, P1055, DOI 10.14309/ajg.0000000000000661 Del Barrio M, 2023, INT J MOL SCI, V24, DOI 10.3390/ijms24076123 Fang YL, 2018, WORLD J GASTROENTERO, V24, P2974, DOI 10.3748/wjg.v24.i27.2974 Gelli C, 2017, WORLD J GASTROENTERO, V23, P3150, DOI 10.3748/wjg.v23.i17.3150 Guasch-Ferré M, 2021, J INTERN MED, V290, P549, DOI 10.1111/joim.13333 Guo W, 2022, NUTRIENTS, V14, DOI 10.3390/nu14245335 Gutiérrez-Cuevas J, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms222111629 Habibullah M, 2024, FRONT MED-LAUSANNE, V11, DOI 10.3389/fmed.2024.1291501 Jasirwan COM, 2021, BIOSCI MICROB FOOD H, V40, P50, DOI 10.12938/bmfh.2020-046 Jasirwan COM, 2019, BIOSCI MICROB FOOD H, V38, P81, DOI 10.12938/bmfh.18-032 Kim SK, 2019, J MICROBIOL BIOTECHN, V29, P1335, DOI 10.4014/jmb.1906.06064 Kobyliak N, 2018, J GASTROINTEST LIVER, V27, P41, DOI 10.15403/jgld.2014.1121.271.kby Kübeck R, 2016, MOL METAB, V5, P1162, DOI 10.1016/j.molmet.2016.10.001 Kulawik A, 2023, NUTRIENTS, V15, DOI 10.3390/nu15173821 Leung C, 2016, NAT REV GASTRO HEPAT, V13, P412, DOI 10.1038/nrgastro.2016.85 Li ZJ, 2022, WORLD J GASTROENTERO, V28, P6213, DOI 10.3748/wjg.v28.i44.6213 Li ZP, 2003, HEPATOLOGY, V37, P343, DOI 10.1053/jhep.2003.50048 Lozupone CA, 2012, NATURE, V489, P220, DOI 10.1038/nature11550 Malakou E, 2018, NUTRIENTS, V10, DOI 10.3390/nu10111577 Malnick SDH, 2023, CURR ISSUES MOL BIOL, V45, P7197, DOI 10.3390/cimb45090455 Manzhalii E, 2017, J DIGEST DIS, V18, P698, DOI 10.1111/1751-2980.12561 Milosevic I, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20020395 Nor MHM, 2021, NUTRIENTS, V13, DOI 10.3390/nu13093192 Novakova Barbora, 2022, Cas Lek Cesk, V161, P65 Patti AM, 2020, METABOLITES, V10, DOI 10.3390/metabo10100392 Pelusi S, 2019, HEPATOBIL SURG NUTR, V8, P173, DOI 10.21037/hbsn.2018.12.07 Perazzo H, 2024, J HEPATOL, V80, pe72, DOI 10.1016/j.jhep.2023.08.025 Rakotonirina A, 2022, EXPERT OPIN BIOL TH, V22, P929, DOI 10.1080/14712598.2022.2095901 Rinninella E, 2019, MICROORGANISMS, V7, DOI 10.3390/microorganisms7010014 Rinott E, 2021, EUR J INTERN MED, V92, P17, DOI 10.1016/j.ejim.2021.03.038 Sanders ME, 2011, GUT MICROBES, V2, P127, DOI 10.4161/gmic.2.3.16174 Singh T, 2022, J CLIN GASTROENTEROL, V56, P881, DOI 10.1097/MCG.0000000000001610 Stefano JT, 2023, THER ADV ENDOCRINOL, V14, DOI 10.1177/20420188231160394 Tan XY, 2022, EVID-BASED COMPL ALT, V2022, DOI 10.1155/2022/8266793 Tassoni DS, 2023, OBESITIES-BASEL, V3, P296, DOI 10.3390/obesities3040024 Teng MLP, 2023, CLIN MOL HEPATOL, V29, pS32, DOI 10.3350/cmh.2022.0365 Vindigni SM, 2017, GASTROENTEROL CLIN N, V46, P171, DOI 10.1016/j.gtc.2016.09.012 Wang JW, 2019, J FORMOS MED ASSOC, V118, pS23, DOI 10.1016/j.jfma.2018.08.011 Weingarden AR, 2017, GUT MICROBES, V8, P238, DOI 10.1080/19490976.2017.1290757 Witjes JJ, 2020, HEPATOL COMMUN, V4, P1578, DOI 10.1002/hep4.1601 Wong VWS, 2023, J HEPATOL, V79, P842, DOI 10.1016/j.jhep.2023.04.036 Xue LF, 2022, FRONT CELL INFECT MI, V12, DOI 10.3389/fcimb.2022.759306 Younossi ZM, 2023, HEPATOLOGY, V77, P1335, DOI 10.1097/HEP.0000000000000004 NR 61 TC 16 Z9 16 U1 1 U2 5 PU MDPI PI BASEL PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND SN 1010-660X EI 1648-9144 J9 MEDICINA-LITHUANIA JI Med. Lith. PD APR PY 2024 VL 60 IS 4 AR 563 DI 10.3390/medicina60040563 PG 11 WC Medicine, General & Internal WE Science Citation Index Expanded (SCI-EXPANDED) SC General & Internal Medicine GA OW2O5 UT WOS:001210251700001 PM 38674209 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Andre-Dumont, SI Lanthier, N AF Andre-Dumont, Stephanie, I Lanthier, Nicolas TI What diet can we offer to patients with non-alcoholic steatohepatitis? SO NUTRITION CLINIQUE ET METABOLISME LA English DT Article DE NASH; MAFLD; NAFLD; Mediterranean diet; Intermittent fasting ID FATTY LIVER-DISEASE; INSULIN-RESISTANCE; WEIGHT-LOSS; HEPATIC STEATOSIS; CONSUMPTION; FRUCTOSE; ACID AB Metabolic dysfunction-associated fatty liver disease (MAFLD) affects a quarter of the world's population, some of whom will progress to a more severe form called non-alcoholic steatohepatitis (NASH). The main factor leading to this condition is an unbalanced diet. No drug treatment is approved to date and only dietary management can improve the histological lesions of NASH through weight loss. However, the efficacy of standard diets, patient compliance and the ability to maintain weight loss over the long term are common difficulties. In this review, we analyze recent scientific data on different types of diet (Mediterranean diet, intermittent fasting, ketogenic diet), which can bring benefits on general and liver health. Drawbacks or limitations are also listed. The possible benefit of other nutritional strategies (coffee consumption, omega-3, polyphenols. . .) is discussed. The value of dietary change could be tailored to the patient's needs without necessarily imposing an intense weight loss. (c) 2021 Societe francophone nutrition clinique et metabolisme (SFNCM). Published by Elsevier Masson SAS. All rights reserved. C1 [Andre-Dumont, Stephanie, I; Lanthier, Nicolas] Catholic Univ Louvain, Lab Hepatol & Gastroenterol, Inst Rech Expt & Clin IREC, UCLouvain, 52 Ave Mounier, B-1200 Brussels, Belgium. [Lanthier, Nicolas] UCLouvain, Serv Hepatogastroenterol, Clin Univ St Luc, 10 Ave Hippocrate, B-1200 Brussels, Belgium. C3 Universite Catholique Louvain; Universite Catholique Louvain; Cliniques Universitaires Saint-Luc RP Lanthier, N (通讯作者)，Catholic Univ Louvain, Lab Hepatol & Gastroenterol, Inst Rech Expt & Clin IREC, UCLouvain, 52 Ave Mounier, B-1200 Brussels, Belgium.; Lanthier, N (通讯作者)，UCLouvain, Serv Hepatogastroenterol, Clin Univ St Luc, 10 Ave Hippocrate, B-1200 Brussels, Belgium. 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PD FEB PY 2022 VL 36 IS 1 BP 12 EP 20 DI 10.1016/j.nupar.2021.11.001 EA FEB 2022 PG 9 WC Endocrinology & Metabolism; Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Endocrinology & Metabolism; Nutrition & Dietetics GA YZ9DS UT WOS:000755770900003 DA 2026-02-02 ER PT J AU Rong, L Zou, JY Ran, W Qi, XH Chen, YK Cui, HJ Guo, JJ AF Rong, Li Zou, Junyan Ran, Wei Qi, Xiaohong Chen, Yaokai Cui, Hongjuan Guo, Jinjun TI Advancements in the treatment of non-alcoholic fatty liver disease (NAFLD) SO FRONTIERS IN ENDOCRINOLOGY LA English DT Review DE nonalcoholic fatty liver disease; non-alcoholic steatohepatitis; diet; exercise; medical treatment ID PLACEBO-CONTROLLED TRIAL; RANDOMIZED CONTROLLED-TRIAL; TYPE-2 DIABETES-MELLITUS; HEPATIC STEATOSIS; MEDITERRANEAN DIET; BARIATRIC SURGERY; DOUBLE-BLIND; URSODEOXYCHOLIC ACID; OBETICHOLIC ACID; STATIN USE AB Non-alcoholic fatty liver disease (NAFLD) is a series of diseases, involving excessive lipid deposition in the liver and is often accompanied by obesity, diabetes, dyslipidemia, abnormal blood pressure, and other metabolic disorders. In order to more accurately reflect its pathogenesis, an international consensus renamed NAFLD in 2020 as metabolic (dysfunction) associated with fatty liver disease (MAFLD). The changes in diet and lifestyle are recognized the non-drug treatment strategies; however, due to the complex pathogenesis of NAFLD, the current drug therapies are mainly focused on its pathogenic factors, key links of pathogenesis, and related metabolic disorders as targets. There is still a lack of specific drugs. In clinical studies, the common NAFLD treatments include the regulation of glucose and lipid metabolism to protect the liver and anti-inflammation. The NAFLD treatments based on the enterohepatic axis, targeting gut microbiota, are gradually emerging, and various new metabolism-regulating drugs are also under clinical development. Therefore, this review article has comprehensively discussed the research advancements in NAFLD treatment in recent years. C1 [Rong, Li; Guo, Jinjun] Chongqing Med Univ, Bishan Hosp, Dept Gastroenterol, Chongqing, Peoples R China. [Zou, Junyan; Cui, Hongjuan] Southwest Univ, Med Res Inst, Chongqing, Peoples R China. [Zou, Junyan; Ran, Wei; Chen, Yaokai] Southwest Univ, Publ Hlth Hosp, Med Res Inst, Chongqing, Peoples R China. [Qi, Xiaohong] Baoshan Peoples Hosp Yunnan Prov, Dept Gen Surg, Baoshan, Yunnan, Peoples R China. C3 Chongqing Medical University; Southwest University - China; Southwest University - China RP Guo, JJ (通讯作者)，Chongqing Med Univ, Bishan Hosp, Dept Gastroenterol, Chongqing, Peoples R China. EM guojinjun1972@163.com FU Chongqing Medical Scientific Research Project (Joint Projectof Chongqing Health Commission and Science and Technology Bureau) [2022GDRC019]; Chongqing Natural Science Foundation [CSTB2022NSCQ-MSX1257, cstc2019jcyj-msxmX0752, cstc2018jcyj-AX0006] FX Chongqing Medical Scientific Research Project (Joint Project of Chongqing Health Commission and Science and Technology Bureau) (2022GDRC019) and Chongqing Natural Science Foundation (CSTB2022NSCQ-MSX1257, cstc2019jcyj-msxmX0752, cstc2018jcyj-AX0006). 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Endocrinol. PD JAN 16 PY 2023 VL 13 AR 1087260 DI 10.3389/fendo.2022.1087260 PG 18 WC Endocrinology & Metabolism WE Science Citation Index Expanded (SCI-EXPANDED) SC Endocrinology & Metabolism GA 8I1YZ UT WOS:000921524600001 PM 36726464 OA Green Submitted, gold HC Y HP N DA 2026-02-02 ER PT J AU Dobbie, LJ Burgess, J Hamid, A Nevitt, SJ Hydes, TJ Alam, U Cuthbertson, DJ AF Dobbie, Laurence J. Burgess, Jamie Hamid, Azlinda Nevitt, Sarah J. Hydes, Theresa J. Alam, Uazman Cuthbertson, Daniel J. TI Effect of a Low-Calorie Dietary Intervention on Liver Health and Body Weight in Adults with Metabolic-Dysfunction Associated Steatotic Liver Disease (MASLD) and Overweight/Obesity: A Systematic Review and Meta-Analysis SO NUTRIENTS LA English DT Review DE overweight; obesity; total-diet replacement; Very-Low-Calorie Diet; MASLD; randomised controlled trial; lifestyle medicine ID CARBOHYDRATE; RESTRICTION; IMPACT; SERUM AB Introduction: Metabolic-dysfunction Associated Steatotic Liver Disease (MASLD) is a common cause of chronic liver disease. This review assessed the efficacy of a Low-Calorie Diet (LCD) on liver health and body weight in people living with MASLD and obesity. Methods: The study was registered with PROSPERO (CRD42021296501), and a literature search was conducted using multiple databases. The key inclusion criteria were randomised controlled trials or cohort studies, obesity/overweight and MASLD. Two authors screened abstracts, reviewed full texts and performed data extraction and quality assessment. The primary outcome was the change in the serum ALT, and secondary outcomes included the changes in the serum AST, intrahepatic lipid content (IHL), quantified non-invasively via MRI/MRS, and body weight. Results: Fifteen studies were included. The LCD reduced body weight by 9.1 kg versus the control (95%CI: -12.4, -5.8) but not serum ALT (-5.9 IU/L, -13.9, 2.0). Total Dietary Replacement (TDR) reduced IHL by -9.1% vs. the control (-15.6%, -2.6%). The Mediterranean-LCD for >= 12 months reduced ALT (-4.1 IU/L, -7.6, -0.5) and for 24 months reduced liver stiffness versus other LCDs. The Green-Mediterranean-LCD reduced IHL, independent of body weight. Limited studies assessed those of Black or Asian ethnicity, and there was heterogeneity in the methods assessing the liver fat content and fibrosis. Conclusions: In people with MASLD and obesity, an LCD intervention reduces IHL and body weight. Trials should focus on the recruitment of Black and Asian ethnicity participants. C1 [Dobbie, Laurence J.; Burgess, Jamie; Hamid, Azlinda; Hydes, Theresa J.; Alam, Uazman; Cuthbertson, Daniel J.] Univ Liverpool, Inst Life Course & Med Sci, Dept Cardiovasc & Metab Med, Liverpool L9 7AL, England. [Dobbie, Laurence J.] Guys & St Thomas NHS Fdn Trust, Guys Hosp, Dept Diabet & Endocrinol, London SE1 9RT, England. [Burgess, Jamie; Hydes, Theresa J.; Alam, Uazman; Cuthbertson, Daniel J.] Liverpool Univ Hosp NHS Fdn Trust, Univ Hosp Aintree, Liverpool L9 7AL, England. [Nevitt, Sarah J.] Univ Liverpool, Inst Populat Hlth, Dept Hlth Data Sci, Liverpool L3 5TR, England. [Nevitt, Sarah J.] Univ York, Ctr Reviews & Disseminat, York YO10 5DD, England. C3 University of Liverpool; Guy's & St Thomas' NHS Foundation Trust; University of Liverpool; University of York - UK RP Cuthbertson, DJ (通讯作者)，Univ Liverpool, Inst Life Course & Med Sci, Dept Cardiovasc & Metab Med, Liverpool L9 7AL, England.; Cuthbertson, DJ (通讯作者)，Liverpool Univ Hosp NHS Fdn Trust, Univ Hosp Aintree, Liverpool L9 7AL, England. 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10.1111/liv.14164 NR 65 TC 19 Z9 21 U1 0 U2 5 PU MDPI PI BASEL PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND EI 2072-6643 J9 NUTRIENTS JI Nutrients PD APR PY 2024 VL 16 IS 7 AR 1030 DI 10.3390/nu16071030 PG 18 WC Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Nutrition & Dietetics GA NN2Y0 UT WOS:001201076500001 PM 38613063 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Velasco, N Contreras, A Grassi, B AF Velasco, Nicolas Contreras, Alvaro Grassi, Bruno TI The mediterranean diet, hepatic steatosis and nonalcoholic fatty liver disease SO CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE LA English DT Review DE diet therapy; fatty liver; liver diseases; Mediterranean diet; nonalcoholic fatty liver disease ID METABOLIC SYNDROME; RISK; ADHERENCE; PATTERN; CANCER; INDIVIDUALS; IMPROVES; OBESITY AB Purpose of review The purpose of this review is to present the pathophysiological mechanisms and most recent clinical evidence regarding the role of the Mediterranean diet in preventing and treating nonalcoholic fatty liver disease (NAFLD). Recent findings Several components of the Mediterranean diet have proven benefits in controlling the pathophysiological mechanisms involved in NAFLD. However, the few clinical studies that have assessed the diet have involved low numbers of patients and lacked methodological rigor. The results of these studies suggest that the Mediterranean diet attenuates the progression of NAFLD once it is established, but does not contribute to preventing the disease in patients at risk. Summary Although there is a lack of clinical evidence derived from studies with high-quality methodology, the pathophysiological mechanisms of NAFLD shared with other associated pathologies suggest that there is a role for the Mediterranean diet in managing NAFLD. Studies with better methodology are needed to confirm the impact of the diet. C1 [Velasco, Nicolas; Contreras, Alvaro; Grassi, Bruno] Pontificia Univ Catolica Chile, Sch Med, Dept Nutr Diabet & Metab, Santiago, Chile. C3 Pontificia Universidad Catolica de Chile RP Velasco, N (通讯作者)，Alameda 340, Santiago 8330023, Chile. EM nvelasco@med.puc.cl OI Grassi, Bruno/0000-0003-0095-9740 CR Abiemo EE, 2013, BRIT J NUTR, V109, P1490, DOI 10.1017/S0007114512003339 Berentzen TL, 2014, J HEPATOL, V60, P325, DOI 10.1016/j.jhep.2013.09.015 Damasceno NRT, 2013, ATHEROSCLEROSIS, V230, P347, DOI 10.1016/j.atherosclerosis.2013.08.014 DELORGERIL M, 1994, LANCET, V343, P1454, DOI 10.1016/S0140-6736(94)92580-1 Esposito K, 2013, REV ENDOCR METAB DIS, V14, P255, DOI 10.1007/s11154-013-9253-9 Estruch R, 2013, NEW ENGL J MED, V388, P1979 Grosso G, 2014, NUTR METAB CARDIOVAS, V24, P370, DOI 10.1016/j.numecd.2013.09.020 Grosso G, 2013, NUTRIENTS, V5, P4908, DOI 10.3390/nu5124908 Kawamura Y, 2012, AM J GASTROENTEROL, V107, P253, DOI 10.1038/ajg.2011.327 Kesse-Guyot E, 2013, NUTR METAB CARDIOVAS, V23, P677, DOI 10.1016/j.numecd.2012.02.005 KEYS A, 1986, AM J EPIDEMIOL, V124, P903, DOI 10.1093/oxfordjournals.aje.a114480 KEYS A, 1970, CIRCULATION, V41, pI1 Kontogianni M, 2013, CLIN NUTR, V13, pS0261 Liu ZB, 2014, ANAEROBE, V26, P1, DOI 10.1016/j.anaerobe.2013.11.007 Marlow G, 2013, TRANSCRIPTOMIC STUDY McCarthy EM, 2012, J ACAD NUTR DIET, V112, P401, DOI 10.1016/j.jada.2011.10.007 Mehal WZ, 2013, NAT REV GASTRO HEPAT, V10, P637, DOI 10.1038/nrgastro.2013.146 Mouzaki M, 2013, HEPATOLOGY, V58, P120, DOI 10.1002/hep.26319 Oddy WH, 2013, AM J GASTROENTEROL, V108, P778, DOI 10.1038/ajg.2013.95 Ortega E, 2013, ANN NUTR METAB, V62, P339, DOI 10.1159/000346553 Pappachan JM, 2014, ENDOCRINE, V45, P344, DOI 10.1007/s12020-013-0087-8 Poudyal H, 2010, J NUTR, V140, P946, DOI 10.3945/jn.109.117812 Ronis MJJ, 2012, PHYSIOL GENOMICS, V44, P1073, DOI 10.1152/physiolgenomics.00069.2012 Rossi M, 2013, DIABETOLOGIA, V56, P2405, DOI 10.1007/s00125-013-3013-y Ryan MC, 2013, J HEPATOL, V59, P138, DOI 10.1016/j.jhep.2013.02.012 Serviddio G, 2013, FREE RADICAL BIO MED, V65, P952, DOI 10.1016/j.freeradbiomed.2013.08.174 Simopoulos AP, 2001, J NUTR, V131, p3065S, DOI 10.1093/jn/131.11.3065S Slavin J, 2013, NUTRIENTS, V5, P1417, DOI 10.3390/nu5041417 Tanaka K, 2012, JPN J CLIN ONCOL, V42, P212, DOI 10.1093/jjco/hyr198 Mitjavila MT, 2013, CLIN NUTR, V32, P172, DOI 10.1016/j.clnu.2012.08.002 Tokushige K, 2013, J GASTROEN HEPATOL, V28, P88, DOI 10.1111/jgh.12239 Trovato FM, 2014, CLIN NUTR Turati F, 2014, J HEPATOL, V60, P606, DOI 10.1016/j.jhep.2013.10.034 Vos MB, 2013, HEPATOLOGY, V57, P2525, DOI 10.1002/hep.26299 White DL, 2012, CLIN GASTROENTEROL H, V10, P1342, DOI 10.1016/j.cgh.2012.10.001 Wree A, 2013, NAT REV GASTRO HEPAT, V10, P627, DOI 10.1038/nrgastro.2013.149 Zamora-Ros R, 2013, NUTR METAB CARDIOVAS, V23, P1167, DOI 10.1016/j.numecd.2012.12.008 NR 37 TC 29 Z9 32 U1 0 U2 27 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1363-1950 EI 1473-6519 J9 CURR OPIN CLIN NUTR JI Curr. Opin. Clin. Nutr. Metab. Care PD SEP PY 2014 VL 17 IS 5 BP 453 EP 457 DI 10.1097/MCO.0000000000000071 PG 5 WC Endocrinology & Metabolism; Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Endocrinology & Metabolism; Nutrition & Dietetics GA AN6AZ UT WOS:000340677100013 PM 25023188 DA 2026-02-02 ER PT J AU Bernardino, M Tiribelli, C Rosso, N AF Bernardino, Melvin Tiribelli, Claudio Rosso, Natalia TI Exploring the Role of Extra Virgin Olive Oil (EVOO) in MASLD: Evidence from Human Consumption SO NUTRIENTS LA English DT Review DE metabolic dysfunction-associated steatosis liver disease (MASLD); formerly known as non-alcoholic fatty liver disease (NAFLD); mediterranean diet (MD); extra virgin olive oil (EVOO); hepatic steatosis; anti-inflammation; antioxidant effect ID FATTY LIVER-DISEASE; MEDITERRANEAN DIET; SYSTEMATIC REVIEWS; ADHERENCE; INTERVENTION; ACIDS; RISK; SEVERITY; BENEFITS; PATTERN AB Background/Objectives: Metabolic dysfunction-associated steatosis liver disease (MASLD), formerly known as non-alcoholic fatty liver disease (NAFLD) is the leading cause of liver related morbidity and mortality affecting 38% of the adult global population. As of now, there is no clear consensus on a standardized pharmacological treatment for MASLD; therefore, lifestyle interventions particularly diet and exercise remain the first-line approach for both prevention and management. Extra virgin olive oil (EVOO), the primary source of fat in the Mediterranean diet. (MD) is widely recognized as a key contributor to its well-documented health benefits. As a central component of this dietary pattern, EVOO has demonstrated promising therapeutic potential due to its high phenolic content. The primary aim of this review is to synthesize existing human studies examining the effects of olive oil primarily EVOO on key pathological features of MASLD. Methods: A systematic search of human clinical and observational studies was conducted across major databases. Key outcomes assessed include hepatic steatosis, inflammation, oxidative stress, fibrosis, liver enzymes, and anthropometric measures. Study quality was evaluated using the Academy of Nutrition and Dietetics Quality Criteria Checklist. Results: This review included 25 high-quality studies, 12 of which assessed olive oil alone and 13 evaluated the MD emphasizing extra virgin olive oil (EVOO). EVOO-rich interventions consistently improved hepatic steatosis, liver enzyme levels (ALT, AST), and inflammatory markers in MASLD patients, particularly when paired with calorie-restricted or MD patterns. Benefits were dose- and type-dependent, with EVOO showing superior effects compared to refined olive oils. Modest improvements in lipid profiles and insulin resistance were observed. Longer study durations and higher EVOO intake (>30-50 g/day) yielded greater improvements. Findings suggest EVOO may exert beneficial effects on liver health through its anti-inflammatory and antioxidant properties. Future studies on EVOO's role in MASLD should use well-characterized oils with known polyphenol and bioactive compound levels and include clear biomarkers of oxidative stress, inflammation, and liver health outcomes on humans. Overall, EVOO represents a promising, non-pharmacological strategy for MASLD prevention and management. Conclusions: Current evidence suggests that EVOO, particularly when rich in phenolic compounds, is a promising dietary strategy for managing MASLD due to its hepato-protective effects, especially within a Mediterranean diet framework. However, findings are limited by study heterogeneity and a lack of high-quality randomized controlled trials, highlighting the need for future research to refine optimal dosing, assess long-term outcomes, and clarify underlying mechanisms. C1 [Bernardino, Melvin; Tiribelli, Claudio; Rosso, Natalia] Fdn Italiana Fegato, MASLD UNIT, I-34149 Trieste, Italy. [Bernardino, Melvin] Univ Trieste, Dept Life Sci, I-34100 Trieste, Italy. [Bernardino, Melvin] Philippine Council Hlth Res & Dev, Dept Sci & Technol, Taguig 1631, Philippines. C3 University of Trieste; Department of Science & Technology (DOST), Philippines RP Bernardino, M; Rosso, N (通讯作者)，Fdn Italiana Fegato, MASLD UNIT, I-34149 Trieste, Italy.; Bernardino, M (通讯作者)，Univ Trieste, Dept Life Sci, I-34100 Trieste, Italy.; Bernardino, M (通讯作者)，Philippine Council Hlth Res & Dev, Dept Sci & Technol, Taguig 1631, Philippines. EM melvin.bernardino@fegato.it; ctliver@fegato.it; natalia.rosso@fegato.it RI ; Tiribelli, Claudio/A-4716-2014; Rosso, Natalia/K-9035-2016 OI Bernardino, Melvin/0000-0002-3625-6775; Tiribelli, Claudio/0000-0001-6596-7595; Rosso, Natalia/0000-0002-4251-3547 FU DOST-PCHRD (Department of Science and Technology-Philippine Council for Health Research and Development) 2023-2026 [2023-2026, 2024-2025]; DOST-PCHRD (Department of Science and Technology-Philippine Council for Health Research and Development); Fondazione Italiana Fegato, Trieste, Italy FX MB's scholarship is funded by the DOST-PCHRD (Department of Science and Technology-Philippine Council for Health Research and Development) 2023-2026. The study has been funded by O-liver Project (2024-2025) at Fondazione Italiana Fegato, Trieste, Italy. 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10.3390/nu17182932 PG 29 WC Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Nutrition & Dietetics GA 7XT5S UT WOS:001582172600001 PM 41010458 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Hsiang, CY Hsu, KT Lo, HY Hou, YJ Ho, TY AF Hsiang, Chien-Yun Hsu, Kuang-Ting Lo, Hsin-Yi Hou, Yun-Jhu Ho, Tin-Yun TI 2,5-Dihydroxybenzoic Acid Ameliorates Metabolic Dysfunction-Associated Steatotic Liver Disease by Targeting the CCL2-CCR2 Axis to Reduce Lipid Accumulation SO NUTRIENTS LA English DT Article DE metabolic dysfunction-associated steatotic liver disease; 2,5-dihydroxybenzoic acid; chemokine (C-C motif) ligand 2; chemokine (C-C motif) receptor 2 ID DIET AB Background/Objectives: Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most prevalent chronic liver disease worldwide, contributing to metabolic dysfunction and increased healthcare costs. The green Mediterranean diet reduces intrahepatic fat and elevates the plasma levels of 2,5-dihydroxybenzoic acid (2,5-DHBA), suggesting a mechanistic role for 2,5-DHBA in hepatic lipid metabolism. This study aimed to evaluate the therapeutic potential of 2,5-DHBA in MASLD and elucidate its molecular mechanism. Methods: Lipid accumulation was assessed in oleic acid-treated HepG2 cells and a high-fat diet (HFD)-induced MASLD mouse model. RNA sequencing, molecular docking, and immunohistochemical staining were performed to investigate the molecular mechanisms, focusing on the chemokine (C-C motif) ligand 2 (CCL2)-CCL2 receptor (CCR2) axis. Results: 2,5-DHBA significantly reduced hepatic lipid accumulation in both HepG2 cells and HFD-fed mice in a dose-dependent manner. RNA sequencing revealed the marked downregulation of CCL2, a key proinflammatory mediator in MASLD pathogenesis. Molecular docking predicted that 2,5-DHBA competed with CCL2 for binding at the CCR2 axis. Immunohistochemistry further confirmed that 2,5-DHBA treatment lowered hepatic CCL2 expression, suppressed nuclear factor-kappa B activation, and reduced inflammatory cell infiltration. These findings suggest that 2,5-DHBA exerted anti-steatotic effects by modulating the CCL2-CCR2 signaling pathway. Conclusions: This is the first study to demonstrate that 2,5-DHBA attenuates hepatic steatosis via targeting the CCL2-CCR2 axis. These findings highlight its potential as a novel nutraceutical strategy for MASLD treatment. C1 [Hsiang, Chien-Yun] China Med Univ, Dept Microbiol & Immunol, Taichung 404333, Taiwan. [Hsu, Kuang-Ting] China Med Univ, Sch Med, Taichung 404333, Taiwan. [Lo, Hsin-Yi; Ho, Tin-Yun] China Med Univ, Grad Inst Chinese Med, Taichung 404333, Taiwan. [Hou, Yun-Jhu] Natl Taiwan Univ, Dept Anim Sci & Technol, Taipei 106319, Taiwan. [Ho, Tin-Yun] Asia Univ, Dept Hlth & Nutr Biotechnol, Taichung 413305, Taiwan. C3 China Medical University Taiwan; China Medical University Taiwan; China Medical University Taiwan; National Taiwan University; Asia University Taiwan RP Ho, TY (通讯作者)，China Med Univ, Grad Inst Chinese Med, Taichung 404333, Taiwan.; Ho, TY (通讯作者)，Asia Univ, Dept Hlth & Nutr Biotechnol, Taichung 413305, Taiwan. EM cyhsiang@mail.cmu.edu.tw; u109001433@cmu.edu.tw; hsinyilo0123@gmail.com; b13606015@ntu.edu.tw; tyh@mail.cmu.edu.tw OI Ho, Tin-Yun/0000-0003-2390-1461; Hsiang, Chien-Yun/0000-0002-6507-8015 FU National Science and Technology Council; NSTC [113-2321-B-039-004, NSTC 113-2320-B-039-043]; China Medical University [CMU113-MF-51, CMU113-MF-71]; [MOST 111-2320-B-039-035-MY3] FX This work was supported by grants from the National Science and Technology Council (MOST 111-2320-B-039-035-MY3, NSTC 113-2321-B-039-004, and NSTC 113-2320-B-039-043) and China Medical University (CMU113-MF-51, and CMU113-MF-71). 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Bouzas, Cristina Tur, Josep A. TI Association between Non-Alcoholic Fatty Liver Disease and Mediterranean Lifestyle: A Systematic Review SO NUTRIENTS LA English DT Article DE non-alcoholic fatty liver disease; mediterranean diet; physical activity; mediterranean lifestyle; metabolic syndrome ID METABOLIC SYNDROME; PHYSICAL-ACTIVITY; DIET; EXERCISE; METAANALYSIS; RESISTANCE; OBESITY; ADULTS AB Background and Aims: Non-alcoholic fatty liver disease (NAFLD) is an excessive accumulation of fat in the liver without alcohol abuse. It is linked to metabolic syndrome (MetS) and no pharmacological treatment exists. This systematic review aims to assess evidence about the effect of Mediterranean lifestyle on the prevention and reversion of NAFLD. Methods: A systematic literature search was performed in MEDLINE via Pubmed. MeSH terms used were: non-alcoholic fatty liver disease [MeSH Major Topic] AND metabolic syndrome [MeSH Term] AND (Diet, Mediterranean [MeSH Term]) OR (Exercise [MeSH Term]). (PROSPERO ID: 2021 CRD42021289495). Results: Thirteen articles were selected and divided into two categories (four focused on Mediterranean diet and NAFLD and nine focused on Mediterranean diet, physical activity, and NAFLD). Information of clinical endpoints was based on NAFLD, as well as MetS, body mass index, fasting glycemia, obesity, cholesterol, triglycerides, transaminases, albuminuria, and hepatic steatosis, among others. All studies found beneficial associations between the clinical parameters of NAFLD/MetS and following a Mediterranean diet and regular physical activity. Conclusions: An effective treatment that prevents, and even reverses, NAFLD is to adapt lifestyle to the Mediterranean one, based on a Mediterranean diet and regular physical activity. C1 [Tur, Josep A.] Univ Balearic Isl, IUNICS, Res Grp Community Nutr & Oxidat Stress, IDISBA, Palma de Mallorca 07122, Spain. CIBEROBN Physiopathol Obes & Nutr CB12 03 30038, Palma De Mallorca 07122, Spain. C3 Universitat de les Illes Balears; IUNICS; Institut Investigacio Sanitaria Illes Balears (IdISBa); CIBER - Centro de Investigacion Biomedica en Red; CIBEROBN RP Tur, JA (通讯作者)，Univ Balearic Isl, IUNICS, Res Grp Community Nutr & Oxidat Stress, IDISBA, Palma de Mallorca 07122, Spain. EM c.mascaro@uib.es; cristina.bouzas@uib.es; pep.tur@uib.es RI ; Tur, Josep/AAE-5748-2020; Bouzas, Cristina/AAE-2069-2019 OI Bouzas Velasco, Cristina/0000-0002-1407-8461; Tur, Josep/0000-0002-6940-0761; FU Spanish government; Institute of Health Carlos III (ISCIII) through the Fondo de Investigacion para la Salud (FIS) [20/004546, RETIC RD06/0045/1004]; CIBEROBN [CB12/03/30038]; EU-COST Action [CA16112]; European Regional Development Fund; [Red Predimed-RETIC RD06/0045/1004] FX The authors were supported by the official funding agency for biomedical research of the Spanish government, Institute of Health Carlos III (ISCIII) through the Fondo de Investigacion para la Salud (FIS) (Projects 20/004546, and Red Predimed-RETIC RD06/0045/1004), CIBEROBN (CB12/03/30038), EU-COST Action CA16112, which are co-funded by the European Regional Development Fund. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. 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Western dietary patterns along with a sedentary lifestyle are key contributors to the ongoing global metabolic disease epidemic. Little is known about the role of dietary habits in the modulation of HCC risk.Objective The aim of this review was to comprehensively examine established and putative links between dietary components and HCC risk.Methods Information provided in International Agency for Research on Cancer monographs and the 2018 World Cancer Research Fund/American Institute for Cancer Research report was used to identify foods, dietary components, and contaminants indicated as confirmed or potential risk factors for HCC. For each identified item, we performed a search in the PubMed database using the Medical Subject Heading terms of the indicated food items, as well as the generic name of the food item. The search was restricted to systematic reviews and meta-analyses, without publication date restrictions.Results Consumption of red and processed meat, high intake of saturated fatty acids, foods with high glycemic load, and even moderate alcohol intake are associated with higher HCC risk. Cellular damage from low-grade chronic inflammation (meta-inflammation), insulin resistance, and alterations to the composition and metabolic activity of the gut microbiota are potential mechanisms whereby Western pattern diets promote liver carcinogenesis. Conversely, consumption of greater amounts of vegetables, legumes, fruits, and whole grain-derived products could provide the proper amount of fiber intake, polyphenols, and low-glycemic index carbohydrates and alleviate the protumorigenic hepatic microenvironment.Conclusions Nutritional intervention promoting healthy dietary habits is an attractive long-term strategy to reduce HCC risk. Patients with MASLD without advanced fibrosis, excluded from current HCC screening strategies, might be the main target population. C1 [Matray, Chloe] Mil Hosp Percy, Dept Gastroenterol, F-92140 Clamart, France. [Debras, Charlotte; Chatziioannou, Anastasia Chrysovalantou; Jenab, Mazda] Int Agcy Res Canc, Nutr & Metab Branch, F-69007 Lyon, France. [Chatziioannou, Anastasia Chrysovalantou] Univ Crete, Dept Chem, Lab Analyt Biochem, Iraklion 70013, Greece. [Perlemuter, Gabriel; Voican, Cosmin Sebastian] Antoine Beclere Univ Hosp, Dept Hepatogastroenterol & Nutr, AP HP Paris Saclay, F-92140 Clamart, France. [Perlemuter, Gabriel; Voican, Cosmin Sebastian] INSERM, U996, Inflammat Microbiome & Immunosurveillance, F-91400 Orsay, France. [Perlemuter, Gabriel; Voican, Cosmin Sebastian] Paris Saclay Univ, Fac Med, F-94270 Le Kremlin Bicetre, Paris, France. [Voican, Cosmin Sebastian] Innovat Hepatol Hepatinov FHU, F-94800 Villejuif, France. C3 World Health Organization; International Agency for Research on Cancer (IARC); University of Crete; Assistance Publique Hopitaux Paris (APHP); Hopital Universitaire Antoine-Beclere - APHP; Institut National de la Sante et de la Recherche Medicale (Inserm); Universite Paris Saclay RP Voican, CS (通讯作者)，Hop Antoine Beclere, Serv Hepatogastroenterol & Nutr, 157 rue Porte Trivaux, F-92141 Clamart, France. 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Rev. PD DEC PY 2025 VL 83 IS 12 BP 2372 EP 2388 DI 10.1093/nutrit/nuaf129 EA JUL 2025 PG 17 WC Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Nutrition & Dietetics GA 9OD9A UT WOS:001530973500001 PM 40679550 DA 2026-02-02 ER PT J AU Ruiz-Tovar, J Llavero, C Rodriguez-Ortega, M De Castro, NM Martín-Crespo, MC Escobar-Aguilar, G Martin-Nieto, A Gonzalez, G AF Ruiz-Tovar, Jaime Llavero, Carolina Rodriguez-Ortega, Maria De Castro, Nuria M. Martin-Crespo, Maria Cristina Escobar-Aguilar, Gema Martin-Nieto, Ana Gonzalez, Gilberto TI Improvement of Metabolic-Associated Fatty Liver Disease by Magnetic Resonance Spectroscopy in Morbidly Obese Women Undergoing Roux-en-Y Gastric Bypass, following a Postoperative Mediterranean-like Diet SO NUTRIENTS LA English DT Article DE liver steatosis; metabolic-associated fatty liver disease; MAFLD; magnetic resonance spect5roscopy; Roux-en-Y gastric bypass; Mediterranean diet; adherence; morbid obesity; bariatric surgery ID HEPATIC STEATOSIS; WEIGHT-LOSS; BARIATRIC SURGERY; RISK-FACTORS; DYSLIPIDEMIA; ADHERENCE; BENEFITS AB (1) Background: Bariatric surgery has demonstrated the capacity to improve metabolic-associated fatty liver disease (MAFLD) in patients with morbid obesity. In addition, the Mediterranean diet contains anti-inflammatory, anti-oxidative, and anti-fibrotic components, promoting a beneficial effect on MAFLD. This study aimed to assess the improvement of MAFLD, specifically liver steatosis, in morbidly obese patients undergoing Roux-en-Y gastric bypass (RYGB) and following a hypocaloric Mediterranean-like diet. (2) Methods: A prospective observational pilot study of 20 patients undergoing RYGB was conducted. The participants underwent a magnetic resonance spectroscopy study 2 weeks before the surgical act and one year postoperatively to assess the percentage of lipid content (PLC). The adherence to the Mediterranean diet was determined by the KIDMED test 1 year after surgery. (3) Results: Mean baseline PLC was 14.2 +/- 9.4%, and one year after surgery, it decreased to 4.0 +/- 1.8% (p < 0.001). A total of 12 patients (60%) were within the range of moderate adherence to the Mediterranean diet, whereas 8 patients (40%) showed a high adherence. The patients with high adherence to the Mediterranean diet presented significantly lower values of postoperative PLC. (4) Conclusions: Liver steatosis significantly reduces after RYGB. This reduction is further improved when associated with a high adherence to a Mediterranean diet. C1 [Ruiz-Tovar, Jaime; Rodriguez-Ortega, Maria; De Castro, Nuria M.; Martin-Crespo, Maria Cristina; Escobar-Aguilar, Gema; Martin-Nieto, Ana] San Juan Dios Fdn, Madrid 28036, Spain. [Ruiz-Tovar, Jaime; Rodriguez-Ortega, Maria; De Castro, Nuria M.; Martin-Crespo, Maria Cristina; Escobar-Aguilar, Gema; Martin-Nieto, Ana] Comillas Pontif Univ, San Juan Dios Sch Nursing & Phys Therapy, Hlth Sci Dept, Madrid 28036, Spain. [Llavero, Carolina] Garcilaso Clin, Obes Unit, Madrid 28010, Spain. [Gonzalez, Gilberto] Hosp Real San Jose, Guadalajara 19001, Mexico. C3 Comillas Pontifical University RP Ruiz-Tovar, J (通讯作者)，San Juan Dios Fdn, Madrid 28036, Spain.; Ruiz-Tovar, J (通讯作者)，Comillas Pontif Univ, San Juan Dios Sch Nursing & Phys Therapy, Hlth Sci Dept, Madrid 28036, Spain. EM jruiztovar@euef.comillas.edu; carolinallavero@gmail.com; mrortega@comillas.edu; ndecastro@comillas.edu; mmartinc@comillas.edu; gemaescobar@comillas.edu; amartinn@comillas.edu; gilpchmd@yahoo.com.mx OI RUIZ-TOVAR, JAIME/0000-0002-8505-2605; Rodríguez Ortega, María/0000-0002-3721-9626; Martín Nieto, Ana/0000-0003-0252-8557 CR de Carvalho MDA, 2012, NUTR HOSP, V27, P1344, DOI 10.3305/nh.2012.27.4.5890 Angelini G, 2020, AM J PHYSIOL-GASTR L, V319, pG502, DOI 10.1152/ajpgi.00357.2019 Caballeria L, 2019, ATEN PRIM, V51, P525, DOI 10.1016/j.aprim.2019.09.002 Carnevale R, 2018, BRIT J CLIN PHARMACO, V84, P1566, DOI 10.1111/bcp.13589 Cefalu WT, 2016, DIABETES CARE, V39, P857, DOI 10.2337/dc16-0686 Clark JM, 2002, GASTROENTEROLOGY, V122, P1649, DOI 10.1053/gast.2002.33573 Costarelli V, 2013, QUAL LIFE RES, V22, P951, DOI 10.1007/s11136-012-0219-2 Dernini S, 2017, PUBLIC HEALTH NUTR, V20, P1322, DOI 10.1017/S1368980016003177 Di Daniele N, 2013, ACTA DIABETOL, V50, P409, DOI 10.1007/s00592-012-0445-7 Duvnjak M, 2007, WORLD J GASTROENTERO, V13, P4539, DOI 10.3748/wjg.v13.i34.4539 Alsina M, 2017, OBES SURG, V27, P1724, DOI 10.1007/s11695-016-2473-9 Ferrannini E, 2015, DIABETES, V64, P3377, DOI 10.2337/db15-0214 Gastaldo I, 2022, NUTRIENTS, V14, DOI 10.3390/nu14020393 Godos J, 2017, INT J FOOD SCI NUTR, V68, P18, DOI 10.1080/09637486.2016.1214239 le Roux CW, 2006, ANN SURG, V243, P108, DOI 10.1097/01.sla.0000183349.16877.84 Libby AE, 2016, J BIOL CHEM, V291, P24231, DOI 10.1074/jbc.M116.759795 Longo S, 2023, ACTA DIABETOL, V60, P1007, DOI 10.1007/s00592-023-02088-x Lydakis C, 2012, EUR J PEDIATR, V171, P1373, DOI 10.1007/s00431-012-1735-3 Marchesini G, 2016, HEPATOLOGY, V63, P2032, DOI 10.1002/hep.28392 Markovic AK, 2019, MOLECULES, V24, DOI 10.3390/molecules24102001 Mente A, 2009, ARCH INTERN MED, V169, P659, DOI 10.1001/archinternmed.2009.38 Mokhtare M, 2023, CLIN NUTR ESPEN, V58, P221, DOI 10.1016/j.clnesp.2023.10.001 Motomura W, 2006, BIOCHEM BIOPH RES CO, V340, P1111, DOI 10.1016/j.bbrc.2005.12.121 Musso G, 2003, HEPATOLOGY, V37, P909, DOI 10.1053/jhep.2003.50132 Pontiroli AE, 2013, NUTR HOSP, V28, P104, DOI 10.3305/nh.2013.28.sup2.6720 Ratziu V, 2005, GASTROENTEROLOGY, V128, P1898, DOI 10.1053/j.gastro.2005.03.084 Ruiz-Tovar J, 2019, SURG OBES RELAT DIS, V15, P1447, DOI 10.1016/j.soard.2019.05.004 Ruiz-Tovar J, 2014, NUTR HOSP, V30, P756, DOI 10.3305/nh.2014.30.4.7650 Ryan MC, 2013, J HEPATOL, V59, P138, DOI 10.1016/j.jhep.2013.02.012 Saavedra Y, 2022, GASTROENT HEPAT-BARC, V45, P350, DOI 10.1016/j.gastrohep.2021.06.006 Sánchez-Villegas A, 2002, EUR J NUTR, V41, P249, DOI 10.1007/s00394-002-0382-2 Serra-Majem L, 2004, PUBLIC HEALTH NUTR, V7, P931, DOI 10.1079/PHN2004556 Speliotes EK, 2010, HEPATOLOGY, V51, P1979, DOI 10.1002/hep.23593 Tai CM, 2012, OBES SURG, V22, P1016, DOI 10.1007/s11695-011-0579-7 Toledo FGS, 2006, DIABETES CARE, V29, P1845, DOI 10.2337/dc06-0455 Torres-Fuentes C, 2017, LANCET GASTROENTEROL, V2, P747, DOI 10.1016/S2468-1253(17)30147-4 Tosti V, 2018, J GERONTOL A-BIOL, V73, P318, DOI 10.1093/gerona/glx227 van Werven JR, 2010, RADIOLOGY, V256, P159, DOI 10.1148/radiol.10091790 Vargas V, 2012, WORLD J HEPATOL, V4, P382, DOI 10.4254/wjh.v4.i12.382 Velasco N, 2014, CURR OPIN CLIN NUTR, V17, P453, DOI 10.1097/MCO.0000000000000071 Wilkins T, 2013, AM FAM PHYSICIAN, V88, P35 Willett Walter C., 1995, American Journal of Clinical Nutrition, V61, p1402S, DOI 10.1093/ajcn/61.6.1402S Wu L, 2017, BIOCHEMISTRY-US, V56, P5035, DOI 10.1021/acs.biochem.7b00199 NR 43 TC 3 Z9 3 U1 1 U2 3 PU MDPI PI BASEL PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND EI 2072-6643 J9 NUTRIENTS JI Nutrients PD JUL PY 2024 VL 16 IS 14 AR 2280 DI 10.3390/nu16142280 PG 14 WC Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Nutrition & Dietetics GA ZY3W6 UT WOS:001278816600001 PM 39064723 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Paredes-Marin, A He, YL Zhang, XT AF Paredes-Marin, Alejandra He, Yulu Zhang, Xiaotao TI Dietary Interventions in Metabolic Dysfunction-Associated Steatotic Liver Disease: A Narrative Review of Evidence, Mechanisms, and Translational Challenges SO NUTRIENTS LA English DT Review DE diet intervention; MASLD/MASH; steatosis; fibrosis; microbiome; nutrition ID HEPATIC STEATOSIS; PHYSICAL-ACTIVITY; RESISTANT STARCH; MANAGEMENT; NAFLD AB Background/Objectives: Metabolic dysfunction-associated steatotic liver disease (MASLD) is rapidly attracting growing concern around the world. While there has been progress in the development of pharmacologic treatments, lifestyle and dietary interventions remain as the first-line approach for management. This scoping review aimed to identify dietary strategies for managing MASLD and to highlight current research gaps and challenges. Methods: A systematic search of PubMed and Science Direct was conducted up to 10 July 2025, for relevant studies on dietary modifications and MASLD. Data extracted included types of interventions, outcomes related to liver health, and research limitations. Results: Dietary interventions were shown to consistently improve hepatic and metabolic outcomes. In a randomized controlled trial of 12 weeks (n = 259), a Mediterranean diet reduced hepatic steatosis by 39% and improved insulin sensitivity. A calorie-restricted lifestyle program in adults with MASLD (n = 196) reduced liver fat by 25% over 52 weeks. Resistant starch supplementation (n = 200) lowered intrahepatic triglyceride content by 8% through gut microbiome modulation. A pilot RCT of medically tailored meals in cirrhosis (n = 40) reduced ascites symptoms and improved quality of life. Finally, prebiotic supplementation in MASLD (n = 200) lowered systemic inflammation and increased immune-regulating microbes. In contrast, Western dietary patterns and ultra-processed foods were consistently linked to lipotoxicity and inflammation. Conclusions: Dietary interventions remain critical for the management of chronic liver disease and continue to play a vital role even as pharmacotherapy options emerge. Further research should explore precision nutrition and microbiome-based therapies while also addressing the methodological limitations like the underutilization of causal inference frameworks. Finally, it is also important to consider culturally tailored interventions to account for barriers in access and equity in underserved populations. C1 [Paredes-Marin, Alejandra; He, Yulu; Zhang, Xiaotao] Icahn Sch Med Mt Sinai, Dept Med, Div Liver Dis, New York, NY 10029 USA. [Paredes-Marin, Alejandra] Univ Pittsburgh, Med Ctr, Sch Med, Pittsburgh, PA 15260 USA. [He, Yulu; Zhang, Xiaotao] Icahn Sch Med Mt Sinai, Inst Translat Epidemiol, New York, NY 10029 USA. [Zhang, Xiaotao] Icahn Sch Med Mt Sinai, Tisch Canc Inst, Canc Prevent & Control, New York, NY 10029 USA. C3 Icahn School of Medicine at Mount Sinai; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai RP Zhang, XT (通讯作者)，Icahn Sch Med Mt Sinai, Dept Med, Div Liver Dis, New York, NY 10029 USA.; Zhang, XT (通讯作者)，Icahn Sch Med Mt Sinai, Inst Translat Epidemiol, New York, NY 10029 USA.; Zhang, XT (通讯作者)，Icahn Sch Med Mt Sinai, Tisch Canc Inst, Canc Prevent & Control, New York, NY 10029 USA. EM alejandra.paredesmarin@mssm.edu; lulu.he@mountsinai.org; xiaotao.zhang@mountsinai.org RI Zhang, Xiaotao/K-1581-2019 OI Zhang, Xiaotao/0000-0002-3968-5030 FU Siemens Healthineers; Gilead Sciences FX X.Z.: Grant support from Gilead Sciences and Siemens Healthineers. 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MDPI PI BASEL PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND EI 2072-6643 J9 NUTRIENTS JI Nutrients PD NOV 6 PY 2025 VL 17 IS 21 AR 3491 DI 10.3390/nu17213491 PG 19 WC Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Nutrition & Dietetics GA 9QV7U UT WOS:001612851500001 PM 41228562 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Yang, SB Zhang, LT Hu, ML He, WN AF Yang, Shengbo Zhang, Litao Hu, Mingli He, Weina TI MIND diet score and its association with metabolic dysfunction-associated steatotic liver disease and gut microbiota profiles: a cross-sectional study SO FRONTIERS IN NUTRITION LA English DT Article DE MIND diet; metabolic dysfunction-associated steatotic liver disease (MASLD); gut microbiota; insulin resistance; diet; fibrosis; hepatic steatosis; inflammation AB Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a rising health issue linked to poor diet and gut microbiota dysbiosis. The Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet, high in polyphenols and anti-inflammatory nutrients, may help protect against MASLD. This study examined how adherence to the MIND diet relates to MASLD severity, focusing on hepatic steatosis, fibrosis, insulin resistance, inflammation, and gut microbiota diversity. Methods: A cross-sectional analysis of 450 adults with confirmed MASLD was conducted. MIND diet scores were derived from a validated FFQ. Hepatic outcomes were assessed via ultrasonography, hepatic steatosis index (HSI), controlled attenuation parameter (CAP), and fibrosis-4 (FIB-4) index. Biomarkers included liver enzymes (ALT, AST, GGT, and ALP), HOMA-IR, lipid profile, C-reactive protein (CRP), lipopolysaccharide (LPS), and trimethylamine N-oxide (TMAO). Gut microbiota composition was analyzed using 16S rRNA sequencing. Results: Higher MIND scores were associated with reduced steatosis as measured by HSI and CAP, lower fibrosis indicated by the FIB-4 index, improved insulin sensitivity reflected by lower HOMA-IR values, decreased liver enzyme levels, and a more favorable lipid profile. Inflammatory markers (CRP, LPS) decreased with higher adherence (all p < 0.001). Each 1-unit increase in MIND diet score was significantly associated with reductions in fasting insulin (beta = -0.20 mu U/mL; p < 0.001), HOMA-IR (beta = -2.11; p < 0.001), CRP (beta = -2.12; p < 0.001), LPS (beta = -8.52; p < 0.001). Notably, Simpson diversity index scores were higher, and the Firmicutes-to-Bacteroidetes ratio (F/B ratio) was lower, among participants with greater MIND adherence, reflecting improved microbial balance. Mediation analysis revealed that Simpson diversity partially mediated the relationship between MIND score and liver health indicators, suggesting a role for gut microbial diversity in modulating hepatic outcomes. Conclusion: Greater adherence to the MIND diet was associated with indicators of better liver function, lower systemic inflammation, and improved metabolic health, and a more favorable gut microbiota composition in adults with MASLD. C1 [Yang, Shengbo; Zhang, Litao; Hu, Mingli] Guizhou Univ Tradit Chinese Med, Hepatobiliary Pancreat Spleen Surg, Affiliated Hosp 2, Guiyang City, Guizhou Provinc, Peoples R China. [He, Weina] Guizhou Univ Tradit Chinese Med, Emergency Dept, Affiliated Hosp 2, Guiyang City, Guizhou Provinc, Peoples R China. RP Yang, SB (通讯作者)，Guizhou Univ Tradit Chinese Med, Hepatobiliary Pancreat Spleen Surg, Affiliated Hosp 2, Guiyang City, Guizhou Provinc, Peoples R China. 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Nutr. PD AUG 25 PY 2025 VL 12 AR 1637572 DI 10.3389/fnut.2025.1637572 PG 12 WC Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Nutrition & Dietetics GA 7BU5N UT WOS:001567286400001 PM 40927568 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Heredia, NI Thrift, AP Ramsey, DJ Loomba, R El-Serag, HB AF Heredia, Natalia I. Thrift, Aaron P. Ramsey, David J. Loomba, Rohit El-Serag, Hashem B. TI Association of Diet Quality with Metabolic (Dysfunction) Associated Fatty Liver Disease in Veterans in Primary Care SO NUTRIENTS LA English DT Article DE metabolic (dysfunction) associated fatty liver disease; Veterans; Healthy Eating Index; Mediterranean Diet ID MEDITERRANEAN DIET; 24-HOUR RECALL; FIBROSIS; COHORT; VALIDATION; DIAGNOSIS; CANCER AB Background: Diet is associated with metabolic (dysfunction)-associated fatty liver disease (MAFLD), but the dietary composition associated with MAFLD risk has not been well-examined. Aim: The purpose of this study was to assess the association of two healthy eating indices with the presence and severity of MAFLD in a sample of Veterans in a primary care setting. Methods: This was a single center cross-sectional study using a random stratified sample of Veterans enrolled in primary care. Participants underwent a Fibroscan and completed an interviewer-administered Diet History Questionnaire II from which we calculated the Healthy Eating Index-2015 and Alternate Mediterranean Diet Score. We used multivariable logistic regression models to assess associations of dietary quality with MAFLD. Results: We analyzed data from 187 participants, 53.5% of whom were female. On average, participants were 50.2 years of age (SD, 12.3 years) with an average BMI of 31.7 kg/m(2). MAFLD was detected in 78 (42%) and at least moderate fibrosis in 12 (6%) participants. We found that the Alternate Mediterranean Diet Score was inversely associated with MAFLD (adjusted OR = 0.85, 95%CI 0.72-1.00), but controlling for BMI and total energy intake attenuated the association (adjusted OR = 0.92, 95%CI 0.74-1.15). We found no statistically significant associations between the Healthy Eating Index-2015 and MAFLD or advanced fibrosis. Discussion: We found that the Alternate Mediterranean Diet Score was significantly associated with lower MAFLD risk in Veterans; however, the association was mediated by BMI and total energy intake. A Mediterranean-style diet could potentially help reduce the risk of MAFLD, particularly if it helps control total energy intake and weight. C1 [Heredia, Natalia I.] Univ Texas Hlth Sci Ctr Houston, Sch Publ Hlth, Dept Hlth Promot & Behav Sci, Houston, TX 77030 USA. [Thrift, Aaron P.] Baylor Coll Med, Dept Med, Sect Epidemiol & Populat Sci, Houston, TX 77030 USA. [Thrift, Aaron P.] Baylor Coll Med, Dan L Duncan Comprehens Canc Ctr, Houston, TX 77030 USA. [Ramsey, David J.; El-Serag, Hashem B.] Houston VA HSR&D Ctr Innovat Qual Effectiveness &, Michael E DeBakey Vet Affairs Med Ctr, HBE S, Houston, TX 77021 USA. [Ramsey, David J.] Baylor Coll Med, Dept Med, Sect Hlth Serv Res, Houston, TX 77030 USA. [Loomba, Rohit] Univ Calif San Diego, Dept Family Med & Publ Hlth, Div Epidemiol, San Diego, CA 92093 USA. [Loomba, Rohit] Univ Calif San Diego, NAFLD Res Ctr, Div Gastroenterol, La Jolla, CA 92093 USA. [El-Serag, Hashem B.] Baylor Coll Med, Dept Med, Sect Gastroenterol & Hepatol, Houston, TX 77030 USA. C3 University of Texas System; University of Texas Health Science Center Houston; University of Texas School Public Health; Baylor College of Medicine; Baylor College of Medicine; US Department of Veterans Affairs; Veterans Health Administration (VHA); Michael E DeBakey VA Medical Center; Baylor College of Medicine; University of California System; University of California San Diego; University of California System; University of California San Diego; Baylor College of Medicine RP Heredia, NI (通讯作者)，Univ Texas Hlth Sci Ctr Houston, Sch Publ Hlth, Dept Hlth Promot & Behav Sci, Houston, TX 77030 USA. EM natalia.i.heredia@uth.tmc.edu; aaron.thrift@bcm.edu; roloomba@health.ucsd.edu; asheme@bcm.edu RI Loomba, Rohit/AAE-7831-2019; El-Serag, Hashem/AFR-4394-2022; Heredia, Natalia I/AAI-1287-2021 OI Heredia, Natalia I/0000-0001-8086-3700; Thrift, Aaron/0000-0002-0084-5308 FU Department of Veterans Affairs [5I01CX001616-04]; Prevent Cancer Foundation; National Institute of Environmental Health Sciences (NIEHS) [P30ES030285]; NCATS [5UL1TR001442]; NIDDK [U01DK061734, U01DK130190, R01DK106419, R01DK121378, R01DK124318, P30DK120515]; NHLBI [P01HL147835]; NIAAA [U01AA029019]; National Center for Advancing Translational Sciences [UL1TR001442] Funding Source: NIH RePORTER; National Institute of Diabetes and Digestive and Kidney Diseases [U01DK061734, P30DK120515] Funding Source: NIH RePORTER; National Institute of Environmental Health Sciences [P30ES030285] Funding Source: NIH RePORTER; National Institute on Alcohol Abuse and Alcoholism [U01AA029019] Funding Source: NIH RePORTER FX This work was supported by the Department of Veterans Affairs (5I01CX001616-04). This research was also supported in part with resources at the VA HSR&D Center for Innovations in Quality, Effectiveness and Safety (#CIN 13-413), at the Michael E. DeBakey VA Medical Center, Houston, TX. NH was supported by a Prevent Cancer Foundation grant. APT was supported in part by a grant from the National Institute of Environmental Health Sciences (NIEHS; P30ES030285). RL receives funding support from NCATS (5UL1TR001442), NIDDK (U01DK061734, U01DK130190, R01DK106419, R01DK121378, R01DK124318, P30DK120515), NHLBI (P01HL147835), and NIAAA (U01AA029019). The opinions expressed reflect those of the authors and not necessarily those of the Department of Veterans Affairs, the United States Government, or Baylor College of Medicine. 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However, not all people with obesity have an excessive intrahepatic fat content. Adherence to a high-quality dietary pattern may also promote liver health in obesity. A cross-sectional study of 2967 women with overweight and obesity was carried out to assess the association between a Mediterranean diet and fatty liver. All women underwent clinical examination, anthropometric measurements, blood sampling, ultrasound measurements of abdominal visceral and subcutaneous fat, and assessment of adherence to the Mediterranean diet using the 14-item MEDAS questionnaire. Fatty liver index (FLI), NAFLD fatty liver steatosis (NAFLD-FLS) and hepatic steatosis index (HSI) were calculated. In women with obesity, the MEDAS score was inversely associated with FLI (beta = -0.60, 95% CI: -1.04, -0.16, p = 0.008), NAFLD-FLS (beta = -0.092, 95% CI: -0.134, -0.049, p < 0.001) and HSI (beta = -0.17, 95% CI: -0.30, -0.04, p = 0.011). Stronger associations were observed in premenopausal women with obesity. Mediterranean diet was inversely associated with NAFLD-FLS in women with overweight, independently of menopausal status. In conclusion, Mediterranean diet is associated with a better liver status in women with overweight and obesity. This may have a public health impact and be useful in drafting nutritional guidelines for NAFLD. C1 [Leone, Alessandro; Bertoli, Simona; Vignati, Laila; Pellizzari, Marta; Battezzati, Alberto] Univ Milan, Int Ctr Assessment Nutr Status ICANS, Dept Food Environm & Nutr Sci DeFENS, I-20133 Milan, Italy. [Bertoli, Simona] IRCCS, Ist Auxol Italiano, Lab Nutr & Obes Res, I-20145 Milan, Italy. [Bedogni, Giorgio] Alma Mater Studiorum Univ Bologna, Dept Med & Surg Sci, I-40126 Bologna, Italy. [Bedogni, Giorgio] S Maria Croci Hosp, Dept Primary Hlth Care, Internal Med Unit Addressed Frailty & Aging, AUSL Romagna, I-48121 Ravenna, Italy. C3 University of Milan; IRCCS Istituto Auxologico Italiano; University of Bologna; AUSL della Romagna RP Leone, A (通讯作者)，Univ Milan, Int Ctr Assessment Nutr Status ICANS, Dept Food Environm & Nutr Sci DeFENS, I-20133 Milan, Italy. EM alessandro.leone1@unimi.IT RI Bedogni, Giorgio/K-1911-2018; Pellizzari, Marta/JAC-8553-2023; BERTOLI, SIMONA/K-2805-2018; LEONE, ALESSANO/F-4769-2015; Battezzati, Alberto/J-1717-2012 OI Bedogni, Giorgio/0000-0002-1495-9306; Pellizzari, Marta/0000-0001-9338-9147; BERTOLI, SIMONA/0000-0001-5867-8074; LEONE, ALESSANO/0000-0001-8063-8490; FU ICANS internal grant FX This research received no external funding. The Department of Food, Environmental and Nutritional Sciences, Universita degli Studi di Milano, partially covered the open access APC. The remaining was funded by ICANS internal grant. 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10.1186/1476-511X-6-22 Yang JCZ, 2019, NUTRIENTS, V11, DOI 10.3390/nu11040872 Zelber-Sagi S, 2017, LIVER INT, V37, P936, DOI 10.1111/liv.13435 Zhang SM, 2022, INT J EPIDEMIOL, V51, P237, DOI 10.1093/ije/dyab174 NR 72 TC 16 Z9 16 U1 0 U2 7 PU MDPI PI BASEL PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND EI 2072-6643 J9 NUTRIENTS JI Nutrients PD SEP PY 2022 VL 14 IS 18 AR 3771 DI 10.3390/nu14183771 PG 13 WC Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Nutrition & Dietetics GA 4R6IR UT WOS:000856865700001 PM 36145146 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Guveli, H Kenger, EB Ozlu, T Kaya, E Yilmaz, Y AF Guveli, Hakan Kenger, Emre Batuhan Ozlu, Tugce Kaya, Eda Yilmaz, Yusuf TI Macro- and micronutrients in metabolic (dysfunction) associated fatty liver disease: association between advanced fibrosis and high dietary intake of cholesterol/saturated fatty acids SO EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY LA English DT Article DE fibrosis; metabolic (dysfunction) associated fatty liver disease; nutrition; screening ID NONALCOHOLIC STEATOHEPATITIS; TRANSIENT ELASTOGRAPHY; HEPATIC-FIBROSIS; NAFLD; FRUCTOSE AB Background and aim There is still no approved pharmacotherapy for metabolic (dysfunction) associated fatty liver disease (MAFLD). Although dietary and lifestyle modifications for weight loss remain the mainstay for disease management, the association between macro- and micronutrients and fibrosis stage in patients with MAFLD remains unclear. This study was undertaken to address this issue. Methods This is a retrospective analysis of prospectively collected data from patients in whom MAFLD was diagnosed with vibration controlled transient elastography. Steatosis was defined by a controlled attenuation parameter >= 238 dB/m, whereas a liver stiffness measurement >= 11 kPa was considered to indicate advanced fibrosis. Results The study sample consisted of 106 patients with MAFLD (mean age 49 +/- 10 years, 52 men and 54 women). Among the different micro- and macronutrients tested, only the dietary intake of cholesterol and saturated fatty acid (SFA) was independently associated with the presence of advanced fibrosis. Conclusion Our findings suggest that cholesterol/SFA-restricted dietary regimens - as exemplified by the traditional Mediterranean diet - may reduce the risk of advanced fibrosis in patients with MAFLD. Copyright (C) 2021 Wolters Kluwer Health, Inc. All rights reserved. C1 [Guveli, Hakan; Kenger, Emre Batuhan; Ozlu, Tugce] Bahcesehir Univ, Dept Nutr & Dietet, Fac Hlth Sci, Istanbul, Turkey. [Kaya, Eda] Helios Hosp Schleswig, Dept Internal Med, Acad Educ Hosp Luebeck & Kiel Univ, Schleswig, Germany. [Yilmaz, Yusuf] Marmara Univ, Dept Gastroenterol, Sch Med, Istanbul, Turkey. [Yilmaz, Yusuf] Marmara Univ, Liver Res Unit, Inst Gastroenterol, Istanbul, Turkey. C3 Bahcesehir University; Marmara University; Marmara University RP Yilmaz, Y (通讯作者)，Marmara Univ, Sch Med, Dept Gastroenterol, Med, Istanbul, Turkey. EM dryusufyilmaz@gmail.com RI Kaya, Eda/AAN-9567-2020; Yilmaz, Yusuf/K-6651-2012; Ozlu Karahan, Tugce/JJD-5448-2023; kenger, emre batuhan/KYO-9900-2024 OI Kaya, Eda/0000-0002-9293-2811; Yilmaz, Yusuf/0000-0003-4518-5283; Ozlu Karahan, Tugce/0000-0002-0139-676X; kenger, emre batuhan/0000-0002-4761-6836 FU Marmara University Institute of Gastroenterology FX This study was financially supported by Marmara University Institute of Gastroenterology. 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PD DEC PY 2021 VL 33 SU 1 BP E390 EP E394 DI 10.1097/MEG.0000000000002110 PG 5 WC Gastroenterology & Hepatology WE Science Citation Index Expanded (SCI-EXPANDED) SC Gastroenterology & Hepatology GA ZO8XO UT WOS:000766011800051 PM 33731597 DA 2026-02-02 ER PT J AU Kestane, VU Bas, M AF Kestane, Vahibe Ulucay Bas, Murat TI Efficacy of the Mediterranean Diet Containing Different Macronutrients on Non-Alcoholic Fatty Liver Disease SO NUTRIENTS LA English DT Article DE non-alcoholic fatty liver disease; steatohepatitis; Mediterranean diet; liver enzymes; fatty liver index ID MANAGEMENT; NAFLD; NUTRITION; OBESITY; HEALTH AB This study aimed to investigate the effects of the typical Mediterranean diet (TMD), low-carbohydrate Mediterranean diet (LCMD), and low-fat Mediterranean diet (LFMD) on biochemical findings, fatty liver index (FLI), anthropometric measurements, and body composition in individuals with obesity with non-alcoholic fatty liver disease (NAFLD) and insulin resistance. This study included 63 participants with obesity with insulin resistance diagnosed with NAFLD by ultrasonography to investigate the effects of an 8-week energy-restricted TMD, LCMD, and LFMD on biochemical findings, FLI, fibrosis-4 index (FIB-4), anthropometric measurements, and body composition. Patients were randomized into three groups and were interviewed face-to-face every week. According to the food consumption records (baseline end), the difference in the amount of sucrose and total fat consumed in the TMD group; the difference in energy intake from sucrose, monounsaturated fatty acids, and oleic acid in the LCMD group; and the difference in energy intake from fiber, sucrose, monounsaturated and polyunsaturated fatty acids, and cholesterol in the LFMD group showed significant correlations with liver enzymes and FLI (p < 0.05). In conclusion, although it has a different macronutrient composition, the Mediterranean diet may positively affect biochemical parameters and FLI in individuals with NAFLD, albeit in different ways. C1 [Kestane, Vahibe Ulucay] Acibadem Mehmet Ali Aydinlar Univ, Inst Hlth Sci, Dept Nutr & Dietet, TR-34752 Istanbul, Turkiye. [Kestane, Vahibe Ulucay] Istanbul Galata Univ, Inst Hlth Sci, Dept Nutr & Dietet, TR-34432 Istanbul, Turkiye. [Bas, Murat] Acibadem Mehmet Ali Aydinlar Univ, Fac Hlth Sci, Dept Nutr & Dietet, TR-34752 Istanbul, Turkiye. C3 Acibadem University; Acibadem University RP Kestane, VU (通讯作者)，Acibadem Mehmet Ali Aydinlar Univ, Inst Hlth Sci, Dept Nutr & Dietet, TR-34752 Istanbul, Turkiye.; Kestane, VU (通讯作者)，Istanbul Galata Univ, Inst Hlth Sci, Dept Nutr & Dietet, TR-34432 Istanbul, Turkiye. 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NAFLD is a multi-factorial disease whose development involves various processes, such as insulin resistance, lipotoxicity, inflammation, cytokine imbalance, the activation of innate immunity, microbiota and environmental and genetic factors. Numerous clinical studies have shown that the Mediterranean diet produces beneficial effects in NAFLD patients. The aim of this review is to summarize the beneficial effects of lycopene, a soluble pigment found in fruit and vegetables, in NAFLD. C1 [Abenavoli, Ludovico; Procopio, Anna Caterina; Paravati, Maria Rosaria; Costa, Giosue; Alcaro, Stefano; Luzza, Francesco] Magna Graecia Univ Catanzaro, Dept Hlth Sci, I-88100 Catanzaro, Italy. [Costa, Giosue; Alcaro, Stefano] Magna Graecia Univ Catanzaro, Net4Sci Acad Spin Off, I-88100 Catanzaro, Italy. [Costa, Giosue; Alcaro, Stefano] Ctr Ric & Serv Avanzati Innovaz Rurale, Assoc CRISEA, I-88055 Belcastro, Italy. [Milic, Nataga] Univ Novi Sad, Fac Med, Dept Pharm, Hajduk Veljkova 3, Novi Sad 21000, Serbia. C3 Magna Graecia University of Catanzaro; Magna Graecia University of Catanzaro; University of Novi Sad RP Abenavoli, L (通讯作者)，Magna Graecia Univ Catanzaro, Dept Hlth Sci, I-88100 Catanzaro, Italy. EM l.abenavoli@unicz.it; procopioannacaterina@unicz.it; mrparavati@unicz.it; gcosta@unicz.it; natasa.milic@mf.uns.ac.rs; alcaro@unicz.it; luzza@unicz.it RI ; Costa, Giosuè/K-8461-2016; Procopio, Anna Caterina/IAP-0368-2023; MONTEBIANCO ABENAVOLI, Ludovico/J-4394-2019 OI ALCARO, Stefano/0000-0002-0437-358X; Milić, Nataša/0000-0002-8595-6065; Costa, Giosuè/0000-0003-0947-9479; Paravati, Maria Rosaria/0009-0006-8136-3242; Procopio, Anna Caterina/0000-0002-1614-4813; MONTEBIANCO ABENAVOLI, Ludovico/0000-0002-5922-1524; Luzza, Francesco/0000-0001-5120-1046 CR Abenavoli L, 2021, MINERVA GASTROENTERO, V67, P339, DOI 10.23736/S2724-5985.21.02896-5 Abenavoli L, 2017, NUTRIENTS, V9, DOI 10.3390/nu9080870 Agarwal S, 1998, LIPIDS, V33, P981, DOI 10.1007/s11745-998-0295-6 Aller R, 2015, NUTR HOSP, V32, P2518 Anania C, 2018, WORLD J GASTROENTERO, V24, P2083, DOI 10.3748/wjg.v24.i19.2083 Anstee QM, 2013, NAT REV GASTRO HEPAT, V10, P645, DOI 10.1038/nrgastro.2013.182 Arballo J, 2021, ANTIOXIDANTS-BASEL, V10, DOI 10.3390/antiox10030342 Bagetta D, 2020, EUR J MED CHEM, V186, DOI 10.1016/j.ejmech.2019.111903 Bahcecioglu Ibrahim Halil, 2010, Vet Med Int, V2010, DOI 10.4061/2010/262179 Bailey J. 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Clin. Med. PD JUN PY 2022 VL 11 IS 12 AR 3477 DI 10.3390/jcm11123477 PG 12 WC Medicine, General & Internal WE Science Citation Index Expanded (SCI-EXPANDED) SC General & Internal Medicine GA 2K2US UT WOS:000816198200001 PM 35743545 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Boccuto, L Scarlata, GGM Moffitt, BA Sarasua, SM Phelan, K Rogers, C Abenavoli, L AF Boccuto, Luigi Scarlata, Giuseppe Guido Maria Moffitt, Bridgette A. Sarasua, Sara M. Phelan, Katy Rogers, Curtis Abenavoli, Ludovico TI Metabolic Dysfunction-Associated Steatotic Liver Disease in a Patient with Phelan-McDermid Syndrome SO LIFE-BASEL LA English DT Article DE guidelines; diagnosis; treatment; liver steatosis; genetic mutations; pathogenesis AB Background: Phelan-McDermid syndrome (PMS), caused by SHANK3 variants or 22q13.3 deletions, often includes systemic features such as gastrointestinal and hepatic abnormalities. This study highlights the overlap between PMS and metabolic-associated steatotic liver disease (MASLD), focusing on PNPLA3 variants and underscoring the need for structured metabolic monitoring. Methods: We describe a 25-year-old male with PMS due to a 22q13.33 microdeletion involving SHANK3. He exhibited developmental delay, seizures, and hypotonia. Genetic testing revealed homozygosity for the PNPLA3 p.I148M variant. Clinical, anthropometric, biochemical, imaging, and metabolic investigations were performed, including liver ultrasound and metabolic profiling of lymphoblastoid cell lines. Results: Ultrasound revealed moderate hepatic steatosis consistent with MASLD. After ursodeoxycholic acid treatment and a Mediterranean-style diet, steatosis improved to mild. Metabolic profiling demonstrated increased nicotinamide adenine dinucleotide generation under metabolic stimuli, suggesting altered energy homeostasis. Conclusions: We highlight the contribution of PNPLA3 to MASLD in PMS and support systematic hepatic monitoring. Genotype-phenotype associations in PMS may provide insights relevant to MASLD research and clinical management. C1 [Boccuto, Luigi; Moffitt, Bridgette A.; Sarasua, Sara M.] Clemson Univ, Coll Behav Social & Hlth Sci, Sch Nursing, Healthcare Genet & Genom Program, Clemson, SC 29634 USA. [Scarlata, Giuseppe Guido Maria; Abenavoli, Ludovico] Univ Catanzaro Magna Graecia, Dept Hlth Sci, I-88100 Catanzaro, Italy. [Phelan, Katy] Florida Canc Specialists & Res Inst, Genet Lab, Ft Myers, FL 33908 USA. [Rogers, Curtis] Greenwood Genet Ctr, Greenville, SC 29605 USA. C3 Clemson University; Magna Graecia University of Catanzaro; Florida Cancer Specialists; Greenwood Genetic Center RP Abenavoli, L (通讯作者)，Univ Catanzaro Magna Graecia, Dept Hlth Sci, I-88100 Catanzaro, Italy. EM lboccut@clemson.edu; giuseppeguidomaria.scarlata@unicz.it; smsaras@clemson.edu; smsaras@clemson.edu; kphelan@flcancer.com; rcrgenetics@gmail.com; l.abenavoli@unicz.it RI ; MONTEBIANCO ABENAVOLI, Ludovico/J-4394-2019; Scarlata, Giuseppe Guido Maria/IQV-1440-2023 OI Moffitt, Bridgette/0000-0002-5906-2391; MONTEBIANCO ABENAVOLI, Ludovico/0000-0002-5922-1524; Sarasua, Sara/0000-0002-1625-7404; Phelan, Katy/0000-0003-2457-6226; Boccuto, Luigi/0000-0003-2017-4270; Scarlata, Giuseppe Guido Maria/0000-0002-7084-8264 CR Armandi A, 2024, EUR J INTERN MED, V122, P20, DOI 10.1016/j.ejim.2024.01.005 Boccuto L, 2022, GENES-BASEL, V13, DOI 10.3390/genes13030528 Boccuto L, 2018, CLIN GENET, V94, P590, DOI 10.1111/cge.13451 Bolbocean C, 2022, J AUTISM DEV DISORD, V52, P1334, DOI 10.1007/s10803-021-05030-8 Cammarata-Scalisi F, 2022, GENES-BASEL, V13, DOI 10.3390/genes13030504 Chan WK, 2023, J OBES METAB SYNDR, V32, P197, DOI 10.7570/jomes23052 Colaci C, 2024, HEPATOMA RES, V10, DOI 10.20517/2394-5079.2023.134 Delling JP, 2021, J NEURODEV DISORD, V13, DOI 10.1186/s11689-021-09397-8 Dyar B, 2021, GENES-BASEL, V12, DOI 10.3390/genes12081192 Eskridge W, 2023, J CLIN MED, V12, DOI 10.3390/jcm12196216 Frank Y, 2023, J CHILD NEUROL, V38, P665, DOI 10.1177/08830738231204395 Gawrieh Samer, 2025, Clin Gastroenterol Hepatol, DOI 10.1016/j.cgh.2025.08.014 Hashim Muhammad Moseeb Ali, 2025, Cureus, V17, pe86963, DOI 10.7759/cureus.86963 Josephine B., 2024, Arrowhead Pharmaceuticals Gains Full Rights to NASH Candidate ARO-PNPLA3 with Promising Phase 1 Results Kane M., 2012, Medical Genetics Summaries [Internet] Kokkorakis M, 2025, PHARMACOL REV, V77, DOI [10.1124/pharmrev.123.001087, 10.1124/pharmrev.123.001045] Kolevzon A, 2014, J NEURODEV DISORD, V6, DOI 10.1186/1866-1955-6-39 Kozlitina J, 2025, LIVER INT, V45, DOI 10.1111/liv.16123 Landlust AM, 2023, EUR J MED GENET, V66, DOI 10.1016/j.ejmg.2023.104771 Le MH, 2022, CLIN GASTROENTEROL H, V20, P2809, DOI 10.1016/j.cgh.2021.12.002 Lee J, 2025, J GASTROENTEROL, V60, P1284, DOI 10.1007/s00535-025-02285-1 Levy T, 2025, AJIDD-AM J INTELLECT, V130, P395, DOI 10.1352/1944-7558.130.5.395 Lindén D, 2025, LIVER INT, V45, DOI 10.1111/liv.16186 Matuleviciene A, 2023, EUR J MED GENET, V66, DOI 10.1016/j.ejmg.2023.104763 Menotti A, 2025, J CARDIOVASC DEV DIS, V12, DOI [10.3390/jcdd12040141, 10.3390/jcdd12040141] Nahid NA, 2022, EXPERT OPIN DRUG MET, V18, P769, DOI 10.1080/17425255.2022.2160317 Nevado J, 2025, INT J MOL SCI, V26, DOI 10.3390/ijms26104653 Perva IT, 2024, MEDICINA-LITHUANIA, V60, DOI 10.3390/medicina60081366 Pitova V, 2025, SCI REP-UK, V15, DOI 10.1038/s41598-025-11085-9 Rinella ME, 2023, HEPATOLOGY, V78, P1966, DOI 10.1097/HEP.0000000000000520 Romeo S, 2025, LIVER INT, V45, DOI 10.1111/liv.70240 Sato S, 2024, GENES-BASEL, V15, DOI 10.3390/genes15091172 Schön M, 2023, EUR J MED GENET, V66, DOI 10.1016/j.ejmg.2023.104754 Seko Y, 2025, LIVER INT, V45, DOI 10.1111/liv.16124 Sherman DJ, 2024, P NATL ACAD SCI USA, V121, DOI 10.1073/pnas.2318619121 Speliotes EK, 2025, LIVER INT, V45, DOI 10.1111/liv.16106 Srivastava S, 2023, AM J MED GENET A, V191, P2015, DOI 10.1002/ajmg.a.63312 Sullivan KM, 2009, PUBLIC HEALTH REP, V124, P471, DOI 10.1177/003335490912400320 Tacke F, 2024, J HEPATOL, V81, P492, DOI [10.1016/j.jhep.2024.04.031, 10.1159/000539371] Torre P, 2025, INT J MOL SCI, V26, DOI 10.3390/ijms26178426 Tsedendorj Y, 2025, CURR ISSUES MOL BIOL, V47, DOI 10.3390/cimb47080605 Younossi ZM, 2023, HEPATOLOGY, V77, P1335, DOI 10.1097/HEP.0000000000000004 Zhang WY, 2020, ASIA PAC J CLIN NUTR, V29, P696, DOI [10.6133/apjcn.202012_29(4).0004, 10.6133/apjcn.202007_29(3).0004] NR 43 TC 0 Z9 0 U1 0 U2 0 PU MDPI PI BASEL PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND EI 2075-1729 J9 LIFE-BASEL JI Life-Basel PD OCT 11 PY 2025 VL 15 IS 10 AR 1586 DI 10.3390/life15101586 PG 12 WC Biology; Microbiology WE Science Citation Index Expanded (SCI-EXPANDED) SC Life Sciences & Biomedicine - Other Topics; Microbiology GA 9CI4F UT WOS:001602959100001 PM 41157259 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Abdallah, H Khalil, M Awada, E Lanza, ELS Di Ciaula, A Portincasa, P AF Abdallah, Hala Khalil, Mohamad Awada, Ewa Lanza, Elisa Di Ciaula, Agostino Portincasa, Piero TI Metabolic dysfunction-associated steatotic liver disease (MASLD). Assessing metabolic dysfunction, cardiovascular risk factors, and lifestyle habits SO EUROPEAN JOURNAL OF INTERNAL MEDICINE LA English DT Article DE MASLD; Atherosclerotic risk factor; CVD; Mediterranean diet; Metabolic dysfunction ID ATHEROSCLEROSIS RISK; HEPATIC STEATOSIS; VALIDATION; ULTRASOUND; DIAGNOSIS; COHORT; MASLD AB Background and Aims: Steatotic liver disease (SLD), a hallmark of metabolic dysfunction, is closely associated with atherosclerotic cardiovascular disease (ASCVD). This study investigated gender differences, metabolic risk factors, and lifestyle habits in a large cohort of dysmetabolic patients with SLD, reclassified under the novel MASLD framework. Methods: A total of 400 patients (mean age: 58.6 +/- 0.9 years; BMI: 29.0 +/- 0.3 kg/m2; 178 females) were enrolled from a cardiometabolic outpatient clinic. Clinical evaluations included physical examinations, anthropometry, and laboratory analyses. Lifestyle factors including Mediterranean diet (MD) adherence and physical activity were assessed using validated questionnaires. Hepatic steatosis and carotid atherosclerotic plaques were evaluated via ultrasonography. Patients were stratified into MASLD or MetALD (MASLD with high alcohol intake). Metabolic indices and 10-year ASCVD risk scores were calculated. Results: SLD was present in 65.5 % of patients, predominantly as MASLD (93.9 %). Men had higher SLD prevalence and reported greater smoking, alcohol intake, and CVD history. MetALD patients exhibited a higher prevalence of family history of CVD, atherosclerotic plaques, and elevated ASCVD risk, despite similar dysmetabolic profiles compared to MASLD. Among SLD patients, waist circumference was significantly associated with ASCVD risk, whereas MD adherence showed no independent association. The TyG index outperformed FLI, HSI, and MAF-5 in predicting ASCVD risk in patients with low fibrosis risk and no prior major cardiovascular events. Conclusion: Accurate cardiovascular risk stratification in MASLD requires comprehensive phenotyping. Waist circumference is a key risk indicator, and the TyG index may serve as a valuable tool for ASCVD risk prediction in select SLD populations. C1 [Abdallah, Hala; Khalil, Mohamad; Awada, Ewa; Lanza, Elisa; Di Ciaula, Agostino; Portincasa, Piero] Univ Bari Aldo Moro, Clin Med A Murri, Bari, Italy. [Abdallah, Hala; Khalil, Mohamad; Awada, Ewa; Lanza, Elisa; Di Ciaula, Agostino; Portincasa, Piero] Univ Bari Aldo Moro, Dept Precis & Regenerat Med & Ionian area DiMePre, Bari, Italy. [Portincasa, Piero] Consortium Mediterranean Univ, Gen Secretariat, Rome, Italy. C3 Universita degli Studi di Bari Aldo Moro; Universita degli Studi di Bari Aldo Moro RP Khalil, M; Portincasa, P (通讯作者)，Univ Bari Aldo Moro, Clin Med A Murri, Bari, Italy.; Khalil, M; Portincasa, P (通讯作者)，Univ Bari Aldo Moro, Dept Precis & Regenerat Med & Ionian area DiMePre, Bari, Italy.; Portincasa, P (通讯作者)，Consortium Mediterranean Univ, Gen Secretariat, Rome, Italy. EM mohamad.khalil@uniba.it; piero.portincasa@uniba.it RI Di Ciaula, Agostino/M-4300-2017; portincasa, piero/J-7245-2018 OI Di Ciaula, Agostino/0000-0002-5476-7376; portincasa, piero/0000-0001-5359-1471 FU Uppsala Universitet, Sweden; Universidade Nova De Lisboa, Portugal; Fundacio Eurecat; Warszawa, Poland; European Society For Clinical Investigation; Mediagnost Gesellschaft Fur Forschung Und Herstellung Von Diagnostika Gmbh; Coimbra, Portugal FX PP is a grant recipient and MK is an assistant researcher (RTDA) in Project funded under the National Recovery and Resilience Plan (NRRP), Mission 4 Component 2 Investment 1.3-Call for tender No 341 of 15/03/2022 of Italian Ministry of University and Research funded by the European Union-Next Generation EU Award Number: Project code PE0000003, Concession Decree No 1550 of 11/10/2022 adopted by the Italian Ministry of University and Research, CUP D93C22000890001, Project title "Research and innovation network on food and nutrition Sustainability, Safety and Security-Working ON Foods" (ONFoods).P.P. is the coordinator of B4HT projects "Box for Health by Tradition & Innovation: promoting sustainable mediterranean diet by Healthy Foods" funded by the PRIMA project, Section 2-Multi-topic 2022. Project partners: University of Bari Aldo Moro (Italy), University of Genoa (Italy), Lebanese University (Lebanon), and University of Monastir (Tunisia).PP is recipient of HORIZON-HLTH-2022-STAYHLTH-01-05-two-stage Project 101080329-PAS GRAS with the following partners Universidade De Coimbra, Portugal; Uppsala Universitet, Sweden; Universidade Nova De Lisboa, Portugal; Fundacio Eurecat (Eurecat), Barcelona, Spain; Consiglio Nazionale Delle Ricerche (Cnr), Roma Italy; Instituto Politecnico De Viana De Castelo, Viana Do Castelo 4900-347, Portugal; Technische Universitaet Muenchen (Tum), Muenchen, Germany; Instytut Biologii Doswiadczalnej Im. M. Nenckiego Polskiej Akademii Nauk (Nencki), Warszawa, Poland; Instituto Pedro Nunes Associacao Para A Inovacao E Desenvolvimento Em Ciencia E Tecnologia (Ipn), Coimbra, Portugal; The European Society For Clinical Investigation (Esci), Utrecht, Netherlands; Mediagnost Gesellschaft Fur Forschung Und Herstellung Von Diagnostika Gmbh (Mediagnost), Reutlingen, Germany; Martin-Luther-Universitat Halle-Wittenberg (Mlu), Halle, Germany; Associacao Protectora Dos Diabeticos De Portugal (Apdp), Lisboa 1250-203, Portugal; Agdcentro Associacao De Ginastica Do Centro (Agcentro), Coimbra, Portugal.r Universidade De Coimbra, Portugal; Uppsala Universitet, Sweden; Universidade Nova De Lisboa, Portugal; Fundacio Eurecat (Eurecat) , Barcelona, Spain; Consiglio Nazionale Delle Ricerche (Cnr) , Roma Italy; Instituto Politecnico De Viana De Castelo, Viana Do Castelo 4900-347, Portugal; Technische Universitaet Muenchen (Tum) , Muenchen, Germany; Instytut Biologii Doswiadczalnej Im. M. Nenckiego Polskiej Akademii Nauk (Nencki) , Warszawa, Poland; Instituto Pedro Nunes Associacao Para A Inovacao E Desenvolvimento Em Ciencia E Tecnologia (Ipn) , Coimbra, Portugal; The European Society For Clinical Investigation (Esci) , Utrecht, Netherlands; Mediagnost Gesellschaft Fur Forschung Und Herstellung Von Diagnostika Gmbh (Mediagnost) , Reutlingen, Germany; Martin-Luther-Universitat Halle-Wittenberg (Mlu) , Halle, Germany; Associacao Protectora Dos Diabeticos De Portugal (Apdp) , Lisboa 1250-203, Portugal; Agdcentro Associacao De Ginastica Do Centro (Agcentro) , Coimbra, Portugal. 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J. Intern. Med. PD AUG PY 2025 VL 138 BP 101 EP 111 DI 10.1016/j.ejim.2025.05.018 EA AUG 2025 PG 11 WC Medicine, General & Internal WE Science Citation Index Expanded (SCI-EXPANDED) SC General & Internal Medicine GA 5WI6G UT WOS:001545894000014 PM 40436716 OA hybrid DA 2026-02-02 ER PT J AU Karahan, TO Kenger, EB Yilmaz, Y AF Karahan, Tugce Ozlu Kenger, Emre Batuhan Yilmaz, Yusuf TI Artificial Intelligence-Based Diets: A Role in the Nutritional Treatment of Metabolic Dysfunction-Associated Steatotic Liver Disease? SO JOURNAL OF HUMAN NUTRITION AND DIETETICS LA English DT Article DE artificial intelligence; ChatGPT; guideline recommendations; metabolic dysfunction-associated steatotic liver disease; nutritional therapy ID PRACTICE GUIDANCE; MANAGEMENT; ENERGY AB Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a growing global health concern. Effective management of this condition relies heavily on lifestyle modifications and dietary interventions. In this study, we sought to evaluate the dietary plans for MASLD generated by ChatGPT (GPT-4o) according to current guideline recommendations. Methods: ChatGPT was used to create single-day meal plans for 48 simulated patients with MASLD, tailored to individual characteristics such as age, gender, height, weight and transient elastography parameters. The plans were assessed for appropriateness according to disease-specific guidelines. Results: The mean energy content of the menus planned by ChatGPT was 1596.9 +/- 141.5 kcal with a mean accuracy of 91.3 +/- 11.0%, and fibre content was 22.0 +/- 0.6 g with a mean accuracy of 88.1 +/- 2.5%. However, they exhibited elevated levels of protein, fat and saturated fat acids. Conversely, the carbohydrate content was lower. ChatGPT recommended weight loss for obese patients but did not extend this advice to normal-weight and overweight individuals. Notably, recommendations for a Mediterranean diet and physical activity were absent. Conclusions: ChatGPT shows potential in developing dietary plans for MASLD management. However, discrepancies in macronutrient distributions and the omission of key evidence-based recommendations highlight the need for further refinement. To enhance the effectiveness of AI tools in dietary recommendations, alignment with established guidelines must be improved. C1 [Karahan, Tugce Ozlu; Kenger, Emre Batuhan] Istanbul Bilgi Univ, Fac Hlth Sci, Dept Nutr & Dietet, Istanbul, Turkiye. [Yilmaz, Yusuf] Recep Tayyip Erdogan Univ, Sch Med, Dept Gastroenterol, Rize, Turkiye. C3 Istanbul Bilgi University; Recep Tayyip Erdogan University RP Karahan, TO (通讯作者)，Istanbul Bilgi Univ, Fac Hlth Sci, Dept Nutr & Dietet, Istanbul, Turkiye. EM tugce.karahan@bilgi.edu.tr RI Yilmaz, Yusuf/K-6651-2012; kenger, emre batuhan/KYO-9900-2024; Ozlu Karahan, Tugce/JJD-5448-2023 OI Yilmaz, Yusuf/0000-0003-4518-5283; kenger, emre batuhan/0000-0002-4761-6836; Ozlu Karahan, Tugce/0000-0002-0139-676X FU The authors received no specific funding for this work. FX The authors have nothing to report. 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Hum. Nutr. Diet. PD FEB 27 PY 2025 VL 38 IS 2 AR e70033 DI 10.1111/jhn.70033 PG 9 WC Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Nutrition & Dietetics GA Y7B7A UT WOS:001433635900001 PM 40013348 DA 2026-02-02 ER PT J AU Sofi, F Casini, A AF Sofi, Francesco Casini, Alessandro TI Mediterranean diet and non-alcoholic fatty liver disease: New therapeutic option around the corner? SO WORLD JOURNAL OF GASTROENTEROLOGY LA English DT Article DE Mediterranean diet; Diet; Prevention; Metabolic syndrome; Non-alcoholic fatty liver disease ID ALANINE AMINOTRANSFERASE LEVELS; BODY-MASS INDEX; HEPATIC STEATOSIS; CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; WEIGHT-LOSS; STYLE DIET; OLIVE OIL; LONG-TERM; ADHERENCE AB Non-alcoholic fatty liver disease (NAFLD) represents the most common chronic liver disease in Western countries, being considered as the hepatic manifestation of metabolic syndrome. NAFLD has a common pathogenic background to that of metabolic syndrome, and shares many risk factors such as obesity, hypertension, insulin resistance and dyslipidemia. Although there is no currently available evidence-based established treatment for NAFLD, all the recommendations from the medical associations indicate that the most effective treatment is to reduce weight through lifestyle modifications. Diet, indeed, plays a key role in the management of NAFLD patients, as both the quantity and quality of the diet have been reported to have a beneficial role in the onset and severity of the liver disease. Among all the diets that have been proposed, a Mediterranean diet was the most effective dietary option for inducing weight loss together with beneficial effects on all the risk factors associated with metabolic syndrome and NAFLD. Over the last few years, research has demonstrated a beneficial effect of a Mediterranean diet in NAFLD. In this review, we will examine all the available data on the association between diet, nutrients and the Mediterranean diet in association with onset and severity of NAFLD. (C) 2014 Baishideng Publishing Group Inc. All rights reserved. C1 [Sofi, Francesco; Casini, Alessandro] Univ Florence, Dept Expt & Clin Med, I-50134 Florence, Italy. [Sofi, Francesco; Casini, Alessandro] Careggi Univ Hosp, Agcy Nutr, I-50134 Florence, Italy. [Sofi, Francesco] Don Carlo Gnocchi Fdn Florence, I-50134 Florence, Italy. C3 University of Florence; University of Florence; Azienda Ospedaliero Universitaria Careggi; IRCCS Fondazione Don Carlo Gnocchi Onlus RP Sofi, F (通讯作者)，Univ Florence, Dept Expt & Clin Med, Largo Brambilla 3, I-50134 Florence, Italy. 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Gastroenterol. PD JUN 21 PY 2014 VL 20 IS 23 BP 7339 EP 7346 DI 10.3748/wjg.v20.i23.7339 PG 8 WC Gastroenterology & Hepatology WE Science Citation Index Expanded (SCI-EXPANDED) SC Gastroenterology & Hepatology GA AK6EB UT WOS:000338519800024 PM 24966604 OA Green Submitted, hybrid DA 2026-02-02 ER PT J AU Kwanten, WJ AF Kwanten, W. J. TI Diet and non-alcoholic fatty liver disease, a short narrative review SO ACTA GASTRO-ENTEROLOGICA BELGICA LA English DT Review DE NAFLD; diet; lifestyle; review; mediterranean diet; recommendations ID MEDITERRANEAN DIET; HEPATIC STEATOSIS; KETOGENIC DIET; WEIGHT-LOSS; MANAGEMENT; ADULTS AB The growing importance of non-alcoholic fatty liver disease (NAFLD), the biggest non-communicable liver disease, inherently leads to an increased attention to lifestyle and diet that are closely intertwined with NAFLD. Elements of the Western diet such as saturated fats and carbohydrates and thus soft drinks, red meat and ultra-processed foods are linked to NAFLD. Contrarily, diets rich in nuts, fruits, vegetables and unsaturated fats as seen in the Mediterranean diet are linked to less prevalent and less severe NAFLD. In the absence of approved medical therapy for NAFLD, therapy mostly focusses on lifestyle and diet. This short review tries to provide a succinct overview of the current knowledge on the influence of certain diets or individual nutrients on NAFLD and discusses different dietary approaches. It ends with a short list of recommendations that can be used in daily practice. (Acta gastroenterol. belg., 2023, 86, 306-310). C1 [Kwanten, W. J.] Antwerp Univ Hosp UZA, Dept Gastroenterol & Hepatol, Antwerp, Belgium. [Kwanten, W. J.] European Reference Network Rare Hepat Dis ERN RARE, Hamburg, Germany. [Kwanten, W. J.] Univ Antwerp, Fac Med & Hlth Sci, Div Gastroenterol Hepatol, Lab Expt Med & Paediat LEMP, Antwerp, Belgium. [Kwanten, W. J.] Drie Eikenstr 655, B-2650 Edegem, Belgium. C3 University of Antwerp; University of Antwerp RP Kwanten, WJ (通讯作者)，Drie Eikenstr 655, B-2650 Edegem, Belgium. 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Belg. PD JAN-MAR PY 2023 VL 86 IS 1 BP 306 EP 310 DI 10.51821/86.2.11547 PG 5 WC Gastroenterology & Hepatology WE Science Citation Index Expanded (SCI-EXPANDED) SC Gastroenterology & Hepatology GA K2JV6 UT WOS:001014763500001 PM 37428163 OA Green Submitted, Bronze DA 2026-02-02 ER PT J AU Sualeheen, A Tan, SY Daly, RM Georgousopoulou, E Roberts, SK George, ES AF Sualeheen, Ayesha Tan, Sze-Yen Daly, Robin M. Georgousopoulou, Ekavi Roberts, Stuart K. George, Elena-S. TI Higher diet quality is associated with a lower prevalence of MASLD and adverse health outcomes: insights from NHANES 2005 to 2020 SO EUROPEAN JOURNAL OF NUTRITION LA English DT Article DE Diet quality; MASLD; HEI-2020; DASH; MedDietScore; Mortality ID FATTY LIVER-DISEASE; ALL-CAUSE MORTALITY; OLIVE OIL; HYPERTENSION; METAANALYSIS; ADHERENCE; FRUCTOSE; WEIGHT; ADULTS; NAFLD AB PurposeMASLD affects over 30% of the global population increasing the risk of adverse health outcomes. Improvements in diet quality (DQ) may offer a modifiable solution. This study explored the association between DQ and MASLD prevalence, advanced fibrosis, and all-cause mortality.MethodsParticipants from the NHANES U.S. national database were included in the cross-sectional (n = 20,502) and longitudinal (n = 13,161) analysis. DQ assessed using Healthy Eating Index (HEI)-2020, Mediterranean Diet Score (MedDietScore), and Dietary Approach to Stop Hypertension (DASH). MASLD and advanced fibrosis identified by the Fatty Liver Index and NAFLD fibrosis score, respectively. Mortality was ascertained by the National Death Index. Multivariate logistic regression and Cox proportional hazards analysis estimated odds ratios (OR) for MASLD and hazard ratios (HR) for mortality, with 95% confidence interval.ResultsEach 1-SD increase (improvement) in HEI-2020 and MedDietScore was associated with 25% lower likelihood of MASLD, while DASH showed 31% lower likelihood. Each 1-SD increase in HEI-2020, MedDietScore, and DASH was associated with lower ORs for advanced fibrosis in the MASLD group: 0.83 (0.74-0.94), 0.84 (0.75-0.95), and 0.78 (0.68-0.89), respectively. Over 9.3 years' median follow-up, higher DQ was associated with lower all-cause mortality in the overall population [HEI-2020: 0.93 (0.86-0.99); MedDietScore: 0.92 (0.86-0.99); DASH: 0.89 (0.83-0.96)], with similar trends in the non-MASLD group but not in those with MASLD or advanced fibrosis.ConclusionsHigher DQ was associated with lower likelihood of MASLD and advanced fibrosis in U.S. adults and was protective against all-cause mortality in overall and non-MASLD population but not in those with MASLD. C1 [Sualeheen, Ayesha; Tan, Sze-Yen; Daly, Robin M.; George, Elena-S.] Deakin Univ, Inst Phys Act & Nutr IPAN, Sch Exercise & Nutr Sci, Geelong 3220, Australia. [Georgousopoulou, Ekavi] Univ Notre Dame Australia, Sch Med Sydney, Sydney, NSW, Australia. [Georgousopoulou, Ekavi] Univ Canberra, Fac Hlth, Discipline Nutr & Dietet, Canberra, Australia. [Roberts, Stuart K.] Alfred Hlth, Dept Gastroenterol, Melbourne, Vic, Australia. [Roberts, Stuart K.] Monash Univ, Sch Translat Med, Melbourne, Vic, Australia. C3 Deakin University; The University of Notre Dame Australia; University of Notre Dame Australia - Sydney; University of Canberra; Alfred Health; Monash University RP George, ES (通讯作者)，Deakin Univ, Inst Phys Act & Nutr IPAN, Sch Exercise & Nutr Sci, Geelong 3220, Australia. EM elena.george@deakin.edu.au RI George, Elena/J-3357-2019; Tan, Sze/H-5796-2019; Daly, Robin/AAN-2353-2020; Georgousopoulou, Ekavi/AAC-2563-2019 OI Sualeheen, Ayesha/0000-0002-1391-9644; FU CAUL; Deakin University Postgraduate Research Scholarship FX Open Access funding enabled and organized by CAUL and its Member Institutions. Ayesha Sualeheen received Deakin University Postgraduate Research Scholarship while conducting this study. 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J. Nutr. PD OCT PY 2025 VL 64 IS 7 AR 289 DI 10.1007/s00394-025-03809-4 PG 15 WC Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Nutrition & Dietetics GA 8HJ9Y UT WOS:001588724400002 PM 41051618 OA Green Submitted, hybrid DA 2026-02-02 ER PT J AU Reytor-González, C Annunziata, G Campuzano-Donoso, M Morales-López, T Basantes-Tituaña, C Fascì-Spurio, F Verde, L Muscogiuri, G Barrea, L Frias-Toral, E Simancas-Racines, D AF Reytor-Gonzalez, Claudia Annunziata, Giuseppe Campuzano-Donoso, Martin Morales-Lopez, Tania Basantes-Tituana, Carmen Fasci-Spurio, Federica Verde, Ludovica Muscogiuri, Giovanna Barrea, Luigi Frias-Toral, Evelyn Simancas-Racines, Daniel TI Endocrinologist's crucial role in metabolic dysfunction-associated steatotic liver disease: a comprehensive review SO MINERVA ENDOCRINOLOGY LA English DT Review DE Liver diseases; Metabolic syndrome; Endocrinologists; Obesity; Healthcare ID MEDITERRANEAN DIET; INSULIN-RESISTANCE; DIABETES-MELLITUS; HEPATIC STEATOSIS; PRACTICE GUIDANCE; KETOGENIC DIET; OBESITY; MANAGEMENT; RISK; PHARMACOKINETICS AB Metabolic dysfunction-associated steatotic liver disease (MASLD) is a widespread disorder strongly associated with metabolic conditions such as obesity, insulin resistance, and type 2 diabetes (T2D). The progression of MASLD, which can lead to severe complications like hepatic fibrosis and cirrhosis, is closely tied to cardiometabolic risks, including cardiovascular disease, and to liver-related cancers associated with metabolic dysfunction. Endocrinologists are uniquely positioned to detect MASLD early, particularly in individuals with metabolic risk factors such as T2D, polycystic ovary syndrome (PCOS), and thyroid dysfunction. While they may not routinely perform advanced diagnostic procedures, they play a critical role in identifying at-risk patients and collaborating with specialists for further evaluation, including the use of transient elastography to assess liver stiffness and fibrosis. By doing so, they help reduce the need for invasive procedures. Beyond screening and diagnosis, endocrinologists collaborate with hepatologists, cardiologists, and nutritionists to ensure a comprehensive, multidisciplinary treatment approach. Managing MASLD requires addressing both liverspecific conditions and broader metabolic dysfunctions through lifestyle interventions and pharmacological therapies. Recent studies highlight the potential benefits of medications, such as farnesoid X receptor (FXR) agonists and peroxisome proliferator-activated receptor (PPAR) agonists, when combined with lifestyle interventions such as modifying diet and engaging in more physical activity. This review highlights the pivotal role of endocrinologists in managing MASLD, focusing on their contributions to screening, diagnosis, and integrated care. It examines the complex interplay between hormonal regulation and both pharmacological and non-non-pharmacological treatment strategies, providing insights for enhancing clinical practice and improving patient outcomes through a comprehensive, multidisciplinary approach. C1 [Reytor-Gonzalez, Claudia; Frias-Toral, Evelyn; Simancas-Racines, Daniel] Univ UTE, Ctr Invest Salud Publ & Epidemiol Clin CISPEC, Fac Ciencias Salud Eugenio Espejo, Quito 170527, Ecuador. [Annunziata, Giuseppe] Univ Telematica Pegaso, Facolty Human Sci Educ & Sports, Naples, Italy. [Morales-Lopez, Tania; Basantes-Tituana, Carmen] Univ UTE, Fac Ciencias Salud Eugenio Espejo, Quito, Ecuador. [Fasci-Spurio, Federica] Angelo Hosp, Unit Gastroenterol, Venice, Italy. [Verde, Ludovica] Univ Naples Federico II, Dept Publ Hlth, Naples, Italy. [Muscogiuri, Giovanna] Univ Naples Federico II, Dept Clin & Surg Med, Unit Endocrinol Diabetol & Androl, Naples, Italy. [Muscogiuri, Giovanna] Univ Naples Federico II, Ctr Italiano Cura & Benessere Paziente Obes CIBO, Unit Endocrinol Diabetol & Androl, Naples, Italy. [Muscogiuri, Giovanna] Univ Naples Federico II, Cattedra Unesco Educ Alla Salute & Allo Sviluppo, Naples, Italy. [Barrea, Luigi] Univ Telematica Pegaso, Ctr Direzionale, Dept Wellness Nutr & Sports, Via Porzio,Isola,F2, I-80143 Naples, Italy. [Frias-Toral, Evelyn] Holy Spirit Univ, Sch Med, Samborondon, Ecuador. C3 Pegaso Online University; ULSS 3 Serenissima; Ospedale dell'Angelo Mestre; University of Naples Federico II; University of Naples Federico II; University of Naples Federico II; University of Naples Federico II; Pegaso Online University RP Simancas-Racines, D (通讯作者)，Univ UTE, Ctr Invest Salud Publ & Epidemiol Clin CISPEC, Fac Ciencias Salud Eugenio Espejo, Quito 170527, Ecuador. EM dsimancas@ute.edu.ec RI Annunziata, Giuseppe/W-2529-2019; Frias-Toral, Evelyn/AAZ-7346-2020; Barrea, Luigi/K-6551-2016; Muscogiuri, Giovanna/K-5817-2016; Verde, Ludovica/AHB-4097-2022; Campuzano Donoso, Martín/LTD-0339-2024 OI Reytor-González, Claudia/0009-0007-4234-5524; Simancas-Racines, Daniel/0000-0002-3641-1501; Verde, Ludovica/0000-0002-4583-8283; Campuzano Donoso, Martín/0000-0001-5317-8548 FU Universidad UTE FX Funding The publication fee of this paper will be funded by Universidad UTE. 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PD JUN PY 2025 VL 50 IS 2 BP 209 EP 226 DI 10.23736/S2724-6507.24.04314-8 EA MAR 2025 PG 18 WC Endocrinology & Metabolism WE Science Citation Index Expanded (SCI-EXPANDED) SC Endocrinology & Metabolism GA 4PD6V UT WOS:001450808500001 PM 40116171 DA 2026-02-02 ER PT J AU Barbería-Latasa, M Martínez-Urbistondo, D Martínez-González, MA AF Barberia-Latasa, Maria Martinez-Urbistondo, Diego Martinez-Gonzalez, Miguel A. TI The Role of the Mediterranean Diet and Alcohol Consumption in Chronic Liver Disease Prevention: A Narrative Review SO MEDICINA-LITHUANIA LA English DT Review DE Mediterranean diet; MASLD; alcohol consumption; metabolic dysfunction; liver disease ID LOW-FAT DIETS; HEPATIC STEATOSIS; RISK; METAANALYSIS; INDIVIDUALS; ASSOCIATION; MORTALITY; PATTERN; BURDEN; HEALTH AB The traditional Mediterranean Diet (MedDiet) has consistently demonstrated robust benefits in reducing cardiovascular, metabolic, and oncologic risks. Its high content of anti-inflammatory and antioxidant compounds, particularly (poly)phenols, underscores why this dietary pattern has been extensively researched and widely adopted for managing various metabolic conditions. This article aims to conduct a narrative review of the association between the MedDiet (and its debated alcohol consumption pattern) and a reduced risk of liver disease, with a specific focus on the potential preventive role of the MedDiet on Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD), which is now the most prevalent chronic liver disease globally. To carry out this review, relevant articles were searched on PubMed and other databases. The evidence found contributed to identifying the gaps in knowledge and allowed for the main findings to be summarized. Available randomized controlled trials and prospective cohort studies consistently support the hypothesis that high adherence to the MedDiet effectively reduces hepatic fat content, improves liver enzyme levels, and mitigates fibrosis progression. Crucially, this dietary pattern simultaneously addresses the significantly high cardiovascular risk inherent in MASLD. Historically, low-to-moderate alcohol intake, particularly moderate red wine with meals, was assumed to be a beneficial component of the MedDiet. While some observational studies suggest potential cardiovascular benefits, implying a loss of some MedDiet benefits if alcohol is excluded, a growing body of evidence highlights a deleterious synergistic interaction between alcohol, visceral adiposity, hepatic steatosis, and metabolic dysfunction. Based on the available evidence, clinical guidelines recommend the MedDiet with exercise for the prevention and management of MASLD. However, the alcohol consumption in the Mediterranean is currently under strong controversy. Furthermore, recent guidelines now advise total abstinence in patients with advanced liver disease and caution even at earlier MASLD stages. Yet, these assertions are largely based on observational data, underscoring the need for large clinical trials to address this issue with first-level evidence. C1 [Barberia-Latasa, Maria; Martinez-Gonzalez, Miguel A.] Univ Navarra, Dept Prevent Med & Publ Hlth, Inst Invest Sanitaria Navarra IdisNA, Pamplona 31008, Spain. [Martinez-Urbistondo, Diego] Clin Univ Navarra, Dept Internal Med, Area Vasc Med Madrid, Madrid 28027, Spain. [Martinez-Urbistondo, Diego; Martinez-Gonzalez, Miguel A.] Carlos III Hlth Inst, Biomed Res Network Ctr Pathophysiol Obes & Nutr C, Madrid 28029, Spain. [Martinez-Gonzalez, Miguel A.] Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA. C3 University of Navarra; University of Navarra; Harvard University; Harvard T.H. Chan School of Public Health RP Martínez-González, MA (通讯作者)，Univ Navarra, Dept Prevent Med & Publ Hlth, Inst Invest Sanitaria Navarra IdisNA, Pamplona 31008, Spain.; Martínez-González, MA (通讯作者)，Carlos III Hlth Inst, Biomed Res Network Ctr Pathophysiol Obes & Nutr C, Madrid 28029, Spain.; Martínez-González, MA (通讯作者)，Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA. 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2017, LIVER INT, V37, P936, DOI 10.1111/liv.13435 NR 76 TC 0 Z9 0 U1 1 U2 1 PU MDPI PI BASEL PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND SN 1010-660X EI 1648-9144 J9 MEDICINA-LITHUANIA JI Med. Lith. PD OCT 1 PY 2025 VL 61 IS 10 AR 1777 DI 10.3390/medicina61101777 PG 15 WC Medicine, General & Internal WE Science Citation Index Expanded (SCI-EXPANDED) SC General & Internal Medicine GA 9AU6O UT WOS:001601923700001 PM 41155762 OA Green Submitted, gold DA 2026-02-02 ER PT J AU García-Mateo, S Martínez-Domínguez, SJ Gargallo-Puyuelo, CJ Villarino, MTA Laredo, V Gallego, B Alfambra, E Sanz, B Gomollón, F AF Garcia-Mateo, Sandra Martinez-Dominguez, Samuel Jesus Gargallo-Puyuelo, Carla Jerusalen Villarino, Maria Teresa Arroyo Laredo, Viviana Gallego, Beatriz Alfambra, Erika Sanz, Borja Gomollon, Fernando TI When metabolic comorbidities and risk of malnutrition coexist: The new era of inflammatory bowel disease SO AMERICAN JOURNAL OF THE MEDICAL SCIENCES LA English DT Article DE Inflammatory bowel disease; Metabolic dysfunction-associated steatotic liver disease; MUST ID ASSOCIATION; MANAGEMENT; GUIDELINE; CONSENSUS AB Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) and risk of malnutrition can coexist in patients with inflammatory bowel disease (IBD). We performed a malnutrition risk assessment as part of the standard follow-up of IBD patients and studied the potential risk factors for being at risk of malnutrition based on the presence or absence of MASLD. Methods: The Malnutrition Universal Screening Tool (MUST) was used to screen malnutrition risk (MUST >= 1) and controlled attenuation parameter (CAP >= 248 dB/min) to assess MASLD. Adherence to a Mediterranean diet, physical activity, and quality of life were also assessed. Results: Of 686 evaluated IBD patients, 130 (18.9%) were identified as being at risk of malnutrition. Patients without MASLD (n = 89 [68.5%]) were more likely to be at risk than those with MASLD (n = 41 [31.5%], p = 0.005). However, among patients at risk of malnutrition, those with MASLD were more likely to have active IBD (82.9%) than patients without MASLD (39.3%, p < 0.001). Female sex (OR 1.984, p = 0.027) and young age (OR 1.014, p = 0.006) were associated with malnutrition risk only in patients with IBD without MASLD. Being at risk of malnutrition was associated with worse quality of life (p < 0.001), especially in IBD patients with MASLD. Conclusions: Malnutrition risk and quality of life are modified by the presence of MASLD in IBD patients. C1 [Garcia-Mateo, Sandra; Martinez-Dominguez, Samuel Jesus; Gargallo-Puyuelo, Carla Jerusalen; Villarino, Maria Teresa Arroyo; Laredo, Viviana; Gomollon, Fernando] Lozano Blesa Univ Clin Hosp, Dept Gastroenterol, Zaragoza 50009, Spain. [Garcia-Mateo, Sandra; Martinez-Dominguez, Samuel Jesus; Gargallo-Puyuelo, Carla Jerusalen; Laredo, Viviana; Gallego, Beatriz; Alfambra, Erika; Gomollon, Fernando] Aragon Inst Hlth Res IIS Aragon, Zaragoza 50009, Spain. [Garcia-Mateo, Sandra; Martinez-Dominguez, Samuel Jesus; Gargallo-Puyuelo, Carla Jerusalen; Villarino, Maria Teresa Arroyo; Gomollon, Fernando] Univ Zaragoza, Sch Med, Zaragoza 50009, Spain. [Sanz, Borja] Manises Hosp, Dept Endocrinol, Valencia 46940, Spain. C3 Lozano Blesa University Clinical Hospital; University of Zaragoza RP García-Mateo, S (通讯作者)，Calle San Juan Bosco 15, Zaragoza 50009, Spain. EM sgarciamat@salud.aragon.es OI ALFAMBRA, ERIKA/0000-0003-2834-8204; Gargallo, Carla J/0000-0002-3545-2707; Arroyo Villarino, María Teresa/0000-0001-8089-4398 FU FUNDING; GETECCU (Grupo Espan~ol de Trabajo en Enfermedad de Crohn y Colitis Ulcerosa) FX FUNDING This work was supported by a clinical grant provided by GETECCU (Grupo Espan~ol de Trabajo en Enfermedad de Crohn y Colitis Ulcerosa) . 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J. Med. Sci. PD JAN PY 2025 VL 369 IS 1 BP 53 EP 61 DI 10.1016/j.amjms.2024.07.036 EA JAN 2025 PG 9 WC Medicine, General & Internal WE Science Citation Index Expanded (SCI-EXPANDED) SC General & Internal Medicine GA U5Y0Q UT WOS:001412534500001 PM 39098709 DA 2026-02-02 ER PT J AU Montemayor, S García, S Monserrat-Mesquida, M Tur, JA Bouzas, C AF Montemayor, Sofia Garcia, Silvia Monserrat-Mesquida, Margalida Tur, Josep A. Bouzas, Cristina TI Dietary Patterns, Foods, and Nutrients to Ameliorate Non-Alcoholic Fatty Liver Disease: A Scoping Review SO NUTRIENTS LA English DT Review DE NAFLD; nutrients; food; dietary guidelines; dietary recommendations; liver steatosis ID INSULIN-RESISTANCE; COFFEE CONSUMPTION; MEDITERRANEAN DIET; OXIDATIVE STRESS; CONFERS SUSCEPTIBILITY; HEPATIC STEATOSIS; GENETIC-VARIATION; GUT MICROBIOTA; POTENTIAL ROLE; RISK-FACTORS AB Background: Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease without pharmacological treatment yet. There is also a lack of specific dietary recommendations and strategies to treat the negative health impacts derived from NAFLD. Objective: This scoping review aimed to compile dietary patterns, foods, and nutrients to ameliorate NAFLD. Methods: A literature search was performed through MEDLINE, Scopus, Web of Science, and Google Scholar. Results: Several guidelines are available through the literature. Hypocaloric Mediterranean diet is the most accepted dietary pattern to tackle NAFLD. Coffee consumption (sugar free) may have a protective effect for NAFLD. Microbiota also plays a role in NAFLD; hence, fibre intake should be guaranteed. Conclusions: A high-quality diet could improve liver steatosis. Weight loss through hypocaloric diet together with physical activity and limited sugar intake are good strategies for managing NAFLD. Specific dietary recommendations and a Mediterranean plate have been proposed to ameliorate NAFLD. C1 [Montemayor, Sofia; Garcia, Silvia; Monserrat-Mesquida, Margalida; Tur, Josep A.; Bouzas, Cristina] Univ Balearic Isl IUNICS, Res Grp Community Nutr & Oxidat Stress, Palma De Mallorca 07122, Spain. [Montemayor, Sofia; Garcia, Silvia; Monserrat-Mesquida, Margalida; Tur, Josep A.; Bouzas, Cristina] Hlth Res Inst Balearic Isl IdISBa, Palma De Mallorca 07120, Spain. [Garcia, Silvia; Monserrat-Mesquida, Margalida; Tur, Josep A.; Bouzas, Cristina] Inst Salud Carlos III, CIBEROBN Physiopathol Obes & Nutr, Madrid 28029, Spain. C3 Institut Investigacio Sanitaria Illes Balears (IdISBa); Instituto de Salud Carlos III; CIBER - Centro de Investigacion Biomedica en Red; CIBEROBN RP Tur, JA (通讯作者)，Univ Balearic Isl IUNICS, Res Grp Community Nutr & Oxidat Stress, Palma De Mallorca 07122, Spain.; Tur, JA (通讯作者)，Hlth Res Inst Balearic Isl IdISBa, Palma De Mallorca 07120, Spain.; Tur, JA (通讯作者)，Inst Salud Carlos III, CIBEROBN Physiopathol Obes & Nutr, Madrid 28029, Spain. EM pep.tur@uib.es; cristina.bouzas@uib.es RI ; Bouzas, Cristina/AAE-2069-2019; Tur, Josep/AAE-5748-2020; Monserrat Mesquida, Margalida/AAB-4773-2019 OI Montemayor, Sofía/0000-0001-7833-2118; Bouzas Velasco, Cristina/0000-0002-1407-8461; Tur, Josep/0000-0002-6940-0761; Monserrat Mesquida, Margalida/0000-0002-8856-135X FU Institute of Health Carlos III, Madrid, Spain FX The CIBEROBN and the CIBERESP are initiatives of the Institute of Health Carlos III, Madrid, Spain. 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Citation Index Expanded (SCI-EXPANDED) SC Nutrition & Dietetics GA S7KF7 UT WOS:001072915300001 PM 37764771 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Wu, WH Cheng, JC Hou, ZB Yan, Q Wang, XJ He, JH Zhu, YK Li, J AF Wu, Wenhao Cheng, Jiacheng Hou, Zebin Yan, Qi Wang, Xiaojuan He, Junhua Zhu, Yikun Li, Jin TI Association between the dietary index for gut microbiota and all-cause/cardiovascular mortality in patients with metabolic dysfunction-associated steatotic liver disease SO DIABETOLOGY & METABOLIC SYNDROME LA English DT Article DE Metabolic dysfunction-associated steatotic liver disease; Dietary index for gut microbiota; Cardiovascular mortality; All-cause mortality; Gut microbiota; National Health and Nutrition Examination Survey ID MEDITERRANEAN DIET; INSULIN-RESISTANCE; UNITED-STATES; PATTERNS; RISK; PHENOTYPE; DYSBIOSIS; SURVIVAL AB BackgroundNutrient interactions with the gut microbiome modulate the development of metabolic dysfunction-associated steatotic liver disease (MASLD) and cardiovascular disease. The dietary index for gut microbiota (DI-GM) is an innovative and comprehensive diet index to assess quality for health of gut microbiota.MethodThis is a cohort study from the interview date to the date of death or the end of follow-up (December 31, 2019). Involving 13,390 participants in National Health and Nutrition Examination Survey (NHANES), including 3538 with MASLD and 9852 without MASLD. DI-GM was calculated using 14 foods and nutrients with clear positive or negative impacts on gut microbiota, and MASLD was assessed based on liver steatosis and cardiometabolic risk factors, with all-cause and cardiovascular mortality determined through probabilistic matching and death certificate review. Restricted Cubic Spline (RCS) analysis and Cox regression were palyed for the DI-GM-mortality correlation. Subgroup analyses to identify the interactive factors that influence their relationship in MASLD. Six sensitivity analyses reinforced findings.ResultsMASLD participants exhibited lower DI-GM levels, which were statistically associated with higher mortality. Each DI-GM unit increase in MASLD was associated with a 13% lower all-cause mortality (HR = 0.87, 95% CI 0.78-0.98) and a 19.5% lower cardiovascular mortality (HR = 0.805, 95% CI 0.690-0.938). In advanced fibrosis MASLD, this increase was linked to a 20% lower cardiovascular mortality risk (HR = 0.800, 95% CI 0.691-0.927). Age and prediabetes significantly modified DI-GM's effect on mortality risk.ConclusionsThe study revealed a significant inverse correlation between the DI-GM and all-cause/cardiovascular mortality in patients with MASLD, which provide dietary suggestions and guidance for MASLD patients in preventing early mortality. However, limitations such as the cross-sectional design, potential residual confounding, and population-specific generalizability should be considered when interpreting these findings. C1 [Wu, Wenhao; Cheng, Jiacheng; Yan, Qi; Wang, Xiaojuan; He, Junhua; Zhu, Yikun; Li, Jin] Shanxi Med Univ, Hosp 2, Dept Endocrinol & Metab, 56 Xin Jian Rd, Taiyuan 030000, Shanxi, Peoples R China. [Hou, Zebin] Shanxi Prov Peoples Hosp, Dept Thyroid Surg, Taiyuan 030000, Shanxi, Peoples R China. C3 Shanxi Medical University; Shanxi People's Hospital RP Li, J (通讯作者)，Shanxi Med Univ, Hosp 2, Dept Endocrinol & Metab, 56 Xin Jian Rd, Taiyuan 030000, Shanxi, Peoples R China. EM jinli807@126.com FU the National Natural Science Foundation of China; American Centers for Disease Control and Prevention FX The authors appreciate the American Centers for Disease Control and Prevention for conducting the survey and making it available online freely, and all the participants for providing these data. Thanks to Jing Zhang (Shanghai Tongren Hospital) for his work in the NHANES database. His outstanding work, nhanesR package and webpage, makes it easier for us to explore the NHANES database. 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PD JUL 11 PY 2025 VL 17 IS 1 AR 263 DI 10.1186/s13098-025-01846-x PG 17 WC Endocrinology & Metabolism WE Science Citation Index Expanded (SCI-EXPANDED) SC Endocrinology & Metabolism GA 4VJ0G UT WOS:001527557000005 PM 40646653 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Akbulut, UE Isik, IA Atalay, A Eraslan, A Durmus, E Turkmen, S Yurttas, AS AF Akbulut, Ulas Emre Isik, Ishak Abdurrahman Atalay, Atike Eraslan, Ali Durmus, Emin Turkmen, Sinem Yurttas, Aziz Selcuk TI The effect of a Mediterranean diet vs. a low-fat diet on non-alcoholic fatty liver disease in children: a randomized trial SO INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION LA English DT Article DE Obesity; non-alcoholic fatty liver disease; Mediterranean diet; low-fat diet; randomised controlled trial ID LIFE-STYLE INTERVENTIONS; HEPATIC STEATOSIS; EXPERT COMMITTEE; BODY-WEIGHT; OBESITY; RECOMMENDATIONS; OVERWEIGHT; PREVENTION AB Non-alcoholic fatty liver disease (NAFLD) is becoming ever more common in children, due to the increasing global prevalence of obesity. The first-line treatment consists of weight loss through a combination of a healthy diet and exercise. The objective of this study was to determine the effects of a Mediterranean Diet or a low-fat diet on reducing hepatic steatosis and insulin resistance in children with NAFLD. This 12-week randomised clinical trial was conducted with children aged 9-17 years diagnosed with NAFLD and randomised into either a Mediterranean Diet or a low-fat diet group. By the end of the study, hepatic steatosis had decreased significantly in both groups (p < 0.001). Liver enzymes also improved significantly, while significant decreases were observed in insulin resistance in both groups, although this decrease was greater in the Mediterranean Diet group (p = 0.010). This study demonstrated that a decrease in hepatic steatosis and an improvement in insulin sensitivity can be achieved with both a Mediterranean Diet and a low-fat diet over 12 weeks, with no significant decrease in the energy required for growth, in children with NAFLD. C1 [Akbulut, Ulas Emre; Isik, Ishak Abdurrahman; Atalay, Atike] Univ Hlth Sci, Antalya Educ & Res Hosp, Dept Pediat Gastroenterol Hepatol & Nutr, TR-07070 Antalya, Turkey. [Eraslan, Ali] Univ Hlth Sci, Antalya Educ & Res Hosp, Dept Sports Med, Antalya, Turkey. [Durmus, Emin] Univ Hlth Sci, Antalya Educ & Res Hosp, Dept Radiol, Antalya, Turkey. [Turkmen, Sinem; Yurttas, Aziz Selcuk] Univ Hlth Sci, Antalya Educ & Res Hosp, Dept Dietet, Antalya, Turkey. C3 University of Health Sciences Turkey; Antalya Training & Research Hospital; Antalya Training & Research Hospital; University of Health Sciences Turkey; University of Health Sciences Turkey; Antalya Training & Research Hospital; University of Health Sciences Turkey; Antalya Training & Research Hospital RP Akbulut, UE (通讯作者)，Univ Hlth Sci, Antalya Educ & Res Hosp, Dept Pediat Gastroenterol Hepatol & Nutr, TR-07070 Antalya, Turkey. EM ulasemre@hotmail.com RI Durmus, Emin/NRB-5100-2025; Atalay, Atike/HKF-7210-2023; Eraslan, Ali/HKE-1262-2023 OI Akbulut, Ulas Emre/0000-0002-5098-4787; Eraslan, Ali/0000-0001-6909-8198; isik, ishak/0000-0001-8745-8353 CR Abenavoli L, 2019, INT J ENV RES PUB HE, V16, DOI 10.3390/ijerph16173011 Arsik I, 2018, CHILDREN-BASEL, V5, DOI 10.3390/children5060064 Astrup A, 2001, INT J OBESITY, V25, pS46, DOI [10.1038/sj.ijo.0801698, 10.1038/sj/ijo/0801698] Azekour K, 2020, E MEDITERR HEALTH J, V26, P1070, DOI 10.26719/emhj.20.023 Barlow SE, 2007, PEDIATRICS, V120, pS164, DOI 10.1542/peds.2007-2329C Bjermo H, 2012, AM J CLIN NUTR, V95, P1003, DOI 10.3945/ajcn.111.030114 Cohen JC, 2011, SCIENCE, V332, P1519, DOI 10.1126/science.1204265 Davis C, 2015, NUTRIENTS, V7, P9139, DOI 10.3390/nu7115459 Eckard C, 2013, THER ADV GASTROENTER, V6, P249, DOI 10.1177/1756283X13484078 Faul F, 2009, BEHAV RES METHODS, V41, P1149, DOI 10.3758/BRM.41.4.1149 García-Hermoso A, 2019, J SCI MED SPORT, V22, P76, DOI 10.1016/j.jsams.2018.07.006 Gepner Y, 2018, CIRCULATION, V137, P1143, DOI 10.1161/CIRCULATIONAHA.117.030501 Goss AM, 2020, PEDIATR OBES, V15, DOI 10.1111/ijpo.12630 Hamaguchi M, 2007, AM J GASTROENTEROL, V102, P2708, DOI 10.1111/j.1572-0241.2007.01526.x Katsagoni CN, 2017, METABOLISM, V68, P119, DOI 10.1016/j.metabol.2016.12.006 Krishnan S, 2014, EUR J NUTR, V53, P691, DOI 10.1007/s00394-013-0638-z Lee JH, 2010, DIGEST LIVER DIS, V42, P503, DOI 10.1016/j.dld.2009.08.002 Lomonaco R, 2013, DRUGS, V73, P1, DOI 10.1007/s40265-012-0004-0 Moosavian SP, 2020, CLIN NUTR ESPEN, V35, P40, DOI 10.1016/j.clnesp.2019.10.008 Neyzi O, 2015, J CLIN RES PEDIATR E, V7, P280, DOI 10.4274/jcrpe.2183 Panera N, 2018, NUTR RES, V58, P1, DOI 10.1016/j.nutres.2018.05.002 Parra-Vargas M, 2020, NUTRIENTS, V12, DOI 10.3390/nu12123860 Perumpail Brandon J, 2017, Diseases, V5, DOI [10.3390/diseases5040023, 10.3390/diseases5040023] Piers LS, 2003, BRIT J NUTR, V90, P717, DOI 10.1079/BJN2003948 Properzi C, 2018, HEPATOLOGY, V68, P1741, DOI 10.1002/hep.30076 Rachakonda V, 2017, OBESITY, V25, P1360, DOI 10.1002/oby.21890 Ramon-Krauel M, 2013, CHILD OBES, V9, P252, DOI 10.1089/chi.2013.0022 Ryan MC, 2013, J HEPATOL, V59, P138, DOI 10.1016/j.jhep.2013.02.012 Salomone F, 2020, JHEP REP, V2, DOI 10.1016/j.jhepr.2020.100069 Schofield W N, 1985, Hum Nutr Clin Nutr, V39 Suppl 1, P5 Schwimmer JB, 2016, GASTROENTEROLOGY, V151, P1141, DOI 10.1053/j.gastro.2016.08.027 Selvakumar PKC, 2018, PEDIATR DRUGS, V20, P315, DOI 10.1007/s40272-018-0292-2 Tilg H, 2006, GASTROENTEROLOGY, V131, P934, DOI 10.1053/j.gastro.2006.05.054 Torres MCP, 2019, NUTRIENTS, V11, DOI 10.3390/nu11122971 Tutar O, 2014, J PEDIATR GASTR NUTR, V58, P750, DOI 10.1097/MPG.0000000000000329 Vilar-Gomez E, 2015, GASTROENTEROLOGY, V149, P367, DOI 10.1053/j.gastro.2015.04.005 Vos MB, 2017, J PEDIATR GASTR NUTR, V64, P319, DOI 10.1097/MPG.0000000000001482 Vuppalanchi R, 2014, CLIN GASTROENTEROL H, V12, P2121, DOI 10.1016/j.cgh.2014.05.010 Yang M, 2014, NUTRIENTS, V6, P4691, DOI 10.3390/nu6114691 Zelber-Sagi S, 2017, LIVER INT, V37, P936, DOI 10.1111/liv.13435 NR 40 TC 32 Z9 34 U1 3 U2 27 PU TAYLOR & FRANCIS LTD PI ABINGDON PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND SN 0963-7486 EI 1465-3478 J9 INT J FOOD SCI NUTR JI Int. J. Food Sci. Nutr. PD APR 3 PY 2022 VL 73 IS 3 BP 357 EP 366 DI 10.1080/09637486.2021.1979478 EA SEP 2021 PG 10 WC Food Science & Technology; Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Food Science & Technology; Nutrition & Dietetics GA 0L7ZE UT WOS:000700032400001 PM 34565261 DA 2026-02-02 ER PT J AU Ristic-Medic, D Bajerska, J Vucic, V AF Ristic-Medic, Danijela Bajerska, Joanna Vucic, Vesna TI Crosstalk between dietary patterns, obesity and nonalcoholic fatty liver disease SO WORLD JOURNAL OF GASTROENTEROLOGY LA English DT Review DE Nonalcoholic fatty liver disease; Dietary patterns; Obesity; Diet; Mediterranean diet; Nutrition; Treatment; Clinical guidance ID ACHIEVE WEIGHT-LOSS; MEDITERRANEAN DIET; FRUCTOSE CONSUMPTION; METABOLIC SYNDROME; MANAGEMENT; RISK; ASSOCIATION; INFLAMMATION; OVERWEIGHT; PREVENTION AB The prevalence of nonalcoholic fatty liver disease (NAFLD) is rising worldwide, paralleling the epidemic of obesity. The liver is a key organ for the metabolism of proteins, fats and carbohydrates. Various types of fats and carbohydrates in isocaloric diets differently influence fat accumulation in the liver parenchyma. Therefore, nutrition can manage hepatic and cardiometabolic complications of NAFLD. Even moderately reduced caloric intake, which leads to a weight loss of 5%-10% of initial body weight, is effective in improving liver steatosis and surrogate markers of liver disease status. Among dietary patterns, the Mediterranean diet mostly prevents the onset of NAFLD. Furthermore, this diet is also the most recommended for the treatment of NAFLD patients. However, clinical trials based on the dietary interventions in NAFLD patients are sparse. Since there are only a few studies examining dietary interventions in clinically advanced stages of NAFLD, such as active and fibrotic steatohepatitis, the optimal diet for patients in these stages of the disease must still be determined. In this narrative review, we aimed to critically summarize the associations between different dietary patterns, obesity and prevention/risk for NAFLD, to describe specific dietary interventions' impacts on liver steatosis in adults with NAFLD and to provide an updated overview of dietary recommendations that clinicians potentially need to apply in their daily practice. C1 [Ristic-Medic, Danijela; Vucic, Vesna] Natl Inst Republ Serbia, Inst Med Res, Ctr Res Excellence Nutr & Metab, Grp Nutr Biochem & Dietol, POB 102, Belgrade, Serbia. [Bajerska, Joanna] Poznan Univ Life Sci, Dept Human Nutr & Dietet, PL-60624 Poznan, Poland. [Ristic-Medic, Danijela] Natl Inst Republ Serbia, Inst Med Res, Ctr Res Excellence Nutr & Metab, Grp Nutr Biochem & Dietol, Tadeusa Koscuska 1, POB 102, Belgrade, Serbia. C3 University of Belgrade; Poznan University of Life Sciences; University of Belgrade RP Ristic-Medic, D (通讯作者)，Natl Inst Republ Serbia, Inst Med Res, Ctr Res Excellence Nutr & Metab, Grp Nutr Biochem & Dietol, Tadeusa Koscuska 1, POB 102, Belgrade, Serbia. EM dristicmedic@gmail.com RI Vucic, Vesna/AFN-8591-2022; Ristic-Medic, Danijela/J-6624-2013 OI Vucic, Vesna/0000-0002-8563-594X; Ristic-Medic, Danijela/0000-0002-7041-4220 FU Ministry of Education, Science and Technological Development of the Republic of Serbia [451-03-68/2022-14/200042] FX Supported by Ministry of Education, Science and Technological Development of the Republic of Serbia, No. 451-03-68/2022-14/200042. 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Gastroenterol. PD JUL 21 PY 2022 VL 28 IS 27 BP 3314 EP 3333 DI 10.3748/wjg.v28.i27.3314 PG 20 WC Gastroenterology & Hepatology WE Science Citation Index Expanded (SCI-EXPANDED) SC Gastroenterology & Hepatology GA 3V9TQ UT WOS:000842001000003 PM 36158263 OA Green Published, Green Accepted, hybrid DA 2026-02-02 ER PT J AU Godos, J Federico, A Dallio, M Scazzina, F AF Godos, Justyna Federico, Alessandro Dallio, Marcello Scazzina, Francesca TI Mediterranean diet and nonalcoholic fatty liver disease: molecular mechanisms of protection SO INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION LA English DT Review DE Mediterranean diet; nonalcoholic fatty liver disease; polyphenols; dietary intake; whole-grain; polyunsaturated fatty acids ID APPARENTLY HEALTHY-ADULTS; WHOLE-GRAIN; VITAMIN-E; HEPATIC STEATOSIS; METABOLIC SYNDROME; NATURAL-HISTORY; CARDIOVASCULAR-DISEASE; INSULIN SENSITIVITY; ACID REGULATION; GLYCEMIC INDEX AB Nutritional habits modifications have shown an important impact in preventing and ameliorating metabolic alterations, such as nonalcoholic fatty liver disease (NAFLD). Among several dietary approaches that exert positive effects in NAFLD patients, the Mediterranean dietary pattern has shown notable benefits. This review explores the molecular mechanisms through which the Mediterranean diet would improve risk factors associated with metabolic syndrome and NAFLD. The main features of the Mediterranean diet acting on metabolism are represented by its whole-grain and low glycemic index cereal-based items, its fatty acid profile, and its content in phytochemical compounds. Carbohydrate-rich foods high in dietary fiber inducing low glycemic response are able to interact with glucose and insulin metabolism. Unsaturated fatty acids are associated with better hepatic lipid metabolism. Finally, phytochemical compounds, such as dietary polyphenols, are thought to ameliorate inflammation, which is considered one of the mechanisms through which NALFD may evolve into nonalcoholic steatohepatitis (NASH). C1 [Godos, Justyna] Azienda Univ Osped Policlin Vittorio Emanuale, Integrated Canc Registry Catania Messina Siracus, Catania, Italy. [Federico, Alessandro; Dallio, Marcello] Univ Naples 2, Hepatogastroenterol Div, Naples, Italy. [Scazzina, Francesca] Univ Parma, Dept Food Sci, Human Nutr Unit, Parma, Italy. C3 Universita della Campania Vanvitelli; University of Parma RP Godos, J (通讯作者)，Azienda Univ Osped Policlin Vittorio Emanuale, Integrated Canc Registry Catania Messina Siracus, Catania, Italy. 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J. Food Sci. Nutr. PY 2017 VL 68 IS 1 BP 18 EP 27 DI 10.1080/09637486.2016.1214239 PG 10 WC Food Science & Technology; Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Food Science & Technology; Nutrition & Dietetics GA EK6JE UT WOS:000394030100003 PM 27484357 DA 2026-02-02 ER PT J AU Zhang, XT Daniel, CR Soltero, V Vargas, X Jain, S Kanwal, F Thrift, AP Balakrishnan, M AF Zhang, Xiaotao Daniel, Carrie R. Soltero, Valeria Vargas, Ximena Jain, Shilpa Kanwal, Fasiha Thrift, Aaron P. Balakrishnan, Maya TI A Study of Dietary Patterns Derived by Cluster Analysis and Their Association With Metabolic Dysfunction-Associated Steatotic Liver Disease Severity Among Hispanic Patients SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Article DE MASLD; hepatic steatosis; dietary pattern; nutrition; diet; dietary cluster analysis ID MEDITERRANEAN DIET; HEPATIC STEATOSIS; PRACTICE GUIDANCE; MANAGEMENT; ADHERENCE; FIBROSIS; FAT AB INTRODUCTION:Diet is a modifiable metabolic dysfunction-associated steatotic liver disease (MASLD) risk factor, but few studies have been conducted among Hispanic patients, despite the fact that MASLD prevalence and severity are highest among this ethnic subgroup. We aimed to identify prevalent dietary patterns among Hispanic patients using cluster analysis and to investigate associations with MASLD severity.METHODS:This cross-sectional analysis included 421 Harris County MASLD Cohort participants who self-reported Hispanic ethnicity and completed baseline food frequency questionnaires. All included patients had MASLD, diagnosed per standard clinical criteria. K-means analysis was used to identify clusters of patients sharing similar dietary habits. Multivariable adjusted logistic regression was used to estimate associations of dietary clusters with aminotransferases among the overall sample and with histologic steatosis, metabolic dysfunction-associated steatohepatitis, and fibrosis among a subsample of patients who underwent liver biopsy within 6 months of their baseline food frequency questionnaire (n = 186).RESULTS:We identified 2 clusters: a plant-food/prudent and a fast-food/meat pattern. The fast-food/meat pattern was associated with 2.47-fold increased odds (95% confidence interval 1.31-4.65) of more severe steatosis than the plant-food/prudent pattern after adjusting for demographics, metabolic score, physical activity, and alcohol (q = 0.0159). No significant association was observed between diet and aminotransferases, metabolic dysfunction-associated steatohepatitis, or fibrosis.DISCUSSION:Given the importance of sociocultural influences on diet, it is important to understand dietary patterns prevalent among Hispanic patients with MASLD. Using cluster analysis, we identified 1 plant-based pattern vs 1 distinct fast-food/meat-based pattern associated with detrimental effects among our population. This information is an important starting point for tailoring dietary interventions for Hispanic patients with MASLD. C1 [Zhang, Xiaotao; Daniel, Carrie R.] Univ Texas MD Anderson Canc Ctr, Dept Epidemiol, Div Canc Prevent & Populat Sci, Houston, TX USA. [Zhang, Xiaotao] Icahn Sch Med Mt Sinai, Inst Translat Epidemiol, New York, NY USA. [Zhang, Xiaotao] Icahn Sch Med Mt Sinai, Dept Med, Div Liver Dis, New York, NY USA. [Soltero, Valeria; Vargas, Ximena; Kanwal, Fasiha; Balakrishnan, Maya] Baylor Coll Med, Dept Internal Med, Sect Gastroenterol & Hepatol, Houston, TX 77030 USA. [Jain, Shilpa] Baylor Coll Med, Dept Pathol & Immunol, Houston, TX USA. [Kanwal, Fasiha] Michael E DeBakey VA Med Ctr, Houston VA HSR&D Ctr Innovat Qual Effectiveness &, Dept Internal Med, Houston, TX USA. [Thrift, Aaron P.] Baylor Coll Med, Dept Med, Sect Epidemiol & Populat Sci, Houston, TX USA. [Thrift, Aaron P.] Baylor Coll Med, Dan L Duncan Comprehens Canc Ctr, Houston, TX USA. C3 University of Texas System; UTMD Anderson Cancer Center; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Baylor College of Medicine; Baylor College of Medicine; Baylor College of Medicine; Baylor College Medical Hospital; Baylor College of Medicine; Baylor College of Medicine RP Balakrishnan, M (通讯作者)，Baylor Coll Med, Dept Internal Med, Sect Gastroenterol & Hepatol, Houston, TX 77030 USA. EM xiaotao.zhang@mountsinai.org; cdaniel@mdanderson.org; valeria.hnsol@gmail.com; ximena.vargas@bcm.edu; shilpa.jain@bcm.edu; kanwal@bcm.edu; aaron.thrift@bcm.edu; maya.balakrishnan@bcm.edu RI ; Zhang, Xiaotao/K-1581-2019 OI Thrift, Aaron/0000-0002-0084-5308; Zhang, Xiaotao/0000-0002-3968-5030; Balakrishnan, Maya/0000-0002-5196-7284 FU National Institute on Minority Health and Health Disparities; National Cancer Institute [U01CA230997, P50CA217674] Funding Source: NIH RePORTER; National Institute of Diabetes and Digestive and Kidney Diseases [P30DK056338] Funding Source: NIH RePORTER; National Institute of Environmental Health Sciences [P30ES030285] Funding Source: NIH RePORTER; National Institute on Minority Health and Health Disparities [K23MD016955] Funding Source: NIH RePORTER FX No Statement Available CR Angelidi AM, 2022, METABOLISM, V129, DOI 10.1016/j.metabol.2022.155136 [Anonymous], 2016, DIABETOLOGIA, V59, P1121, DOI DOI 10.1007/S00125-016-3902-Y [Anonymous], 2018, SAS/STAT 15.1 User's Guide The CAUSALMED Procedure Baratta F, 2017, AM J GASTROENTEROL, V112, P1832, DOI 10.1038/ajg.2017.371 Batis C, 2011, J NUTR, V141, P1898, DOI 10.3945/jn.111.141473 Bozzetto L, 2012, DIABETES CARE, V35, P1429, DOI 10.2337/dc12-0033 Brunt EM, 2021, HEPATOLOGY, V73, P2028, DOI 10.1002/hep.31599 Chalasani N, 2018, HEPATOLOGY, V67, P328, DOI [10.1002/hep.29367, 10.1038/s42255-021-00344-4] Dulai PS, 2017, HEPATOLOGY, V65, P1557, DOI 10.1002/hep.29085 Gardner CD, 2023, CIRCULATION, V147, P1715, DOI 10.1161/CIR.0000000000001146 Harrison SA, 2021, J HEPATOL, V75, P284, DOI 10.1016/j.jhep.2021.02.034 Zadeh SH, 2021, J GASTROEN HEPATOL, V36, P1470, DOI 10.1111/jgh.15363 He KY, 2020, BRIT J NUTR, V124, P1, DOI 10.1017/S0007114520000914 Heredia NI, 2022, SCI REP-UK, V12, DOI 10.1038/s41598-022-09583-1 Heredia NI, 2022, HISP HEALTH CARE INT, V20, P171, DOI 10.1177/15404153211043885 Ivancovsky-Wajcman D, 2019, CLIN TRANSL GASTROEN, V10, DOI 10.14309/ctg.0000000000000040 Katsagoni CN, 2018, BRIT J NUTR, V120, P164, DOI [10.1017/S000711451800137X, 10.1017/s000711451800137x] Kontogianni MD, 2014, CLIN NUTR, V33, P678, DOI 10.1016/j.clnu.2013.08.014 Kwan SY, 2022, HEPATOLOGY, V75, P955, DOI 10.1002/hep.32197 Lazo M, 2015, CURR DIABETES REP, V15, DOI 10.1007/s11892-015-0674-6 Lichtenstein AH, 2021, CIRCULATION, V144, pE472, DOI 10.1161/CIR.0000000000001031 NCI, 2014, 2014 Family Life, Activity, Sun, Health and Eating (FLASHE) Survey Data Newsome PN, 2020, LANCET GASTROENTEROL, V5, P362, DOI 10.1016/S2468-1253(19)30383-8 Pompili S, 2020, NUTRITION, V75-76, DOI [10.1016/j.nut.2020.110782, 10.1016/j.nut.2020-110782] Properzi C, 2018, HEPATOLOGY, V68, P1741, DOI 10.1002/hep.30076 Riazi K, 2022, LANCET GASTROENTEROL, V7, P851, DOI 10.1016/S2468-1253(22)00165-0 Rinella ME, 2023, HEPATOLOGY, V77, P1797, DOI 10.1097/HEP.0000000000000323 Romeo S, 2008, NAT GENET, V40, P1461, DOI 10.1038/ng.257 Ryan MC, 2013, J HEPATOL, V59, P138, DOI 10.1016/j.jhep.2013.02.012 Schwimmer JB, 2019, JAMA-J AM MED ASSOC, V321, P256, DOI 10.1001/jama.2018.20579 Sharma Shreela V, 2018, Prev Med Rep, V10, P254, DOI [10.1016/j.pmedr.2018.04.005, 10.1016/j.pmedr.2018.04.005] Sotos-Prieto M, 2018, NUTRIENTS, V10, DOI 10.3390/nu10030352 Sun YY, 2022, LIVER INT, V42, P809, DOI 10.1111/liv.15156 Trovato FM, 2015, CLIN NUTR, V34, P86, DOI 10.1016/j.clnu.2014.01.018 Xiao ML, 2020, PUBLIC HEALTH NUTR, V23, P674, DOI 10.1017/S1368980019002568 Zhang XT, 2021, PLOS ONE, V16, DOI 10.1371/journal.pone.0252164 NR 36 TC 5 Z9 5 U1 0 U2 4 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0002-9270 EI 1572-0241 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD MAR PY 2024 VL 119 IS 3 BP 505 EP 511 DI 10.14309/ajg.0000000000002508 PG 7 WC Gastroenterology & Hepatology WE Science Citation Index Expanded (SCI-EXPANDED) SC Gastroenterology & Hepatology GA SU6D8 UT WOS:001236991100030 PM 37737674 OA Green Submitted DA 2026-02-02 ER PT J AU Marin-Alejandre, BA Abete, I Cantero, I Monreal, JI Elorz, M Herrero, JI Benito-Boillos, A Quiroga, J Martinez-Echeverria, A Uriz-Otano, JI Huarte-Muniesa, MP Tur, JA Martinez, JA Zulet, MA AF Araceli Marin-Alejandre, Bertha Abete, Itziar Cantero, Irene Ignacio Monreal, J. Elorz, Mariana Ignacio Herrero, Jose Benito-Boillos, Alberto Quiroga, Jorge Martinez-Echeverria, Ana Isidro Uriz-Otano, Juan Pilar Huarte-Muniesa, Maria Tur, Josep A. Alfredo Martinez, J. Angeles Zulet, M. TI The Metabolic and Hepatic Impact of Two Personalized Dietary Strategies in Subjects with Obesity and Nonalcoholic Fatty Liver Disease: The Fatty Liver in Obesity (FLiO) Randomized Controlled Trial SO NUTRIENTS LA English DT Article DE Obesity; NAFLD; dietary intervention; AHA; FLiO; fatty liver; Mediterranean Diet ID CLINICAL CHARACTERISTICS; MEDITERRANEAN DIET; WEIGHT-LOSS; LIFE-STYLE; INTERVENTIONS; ADHERENCE; PATTERN; NAFLD AB The prevalence of nonalcoholic fatty liver disease (NAFLD) is increasing worldwide. NAFLD management is mainly focused on weight loss, but the optimal characteristics of the diet demand further investigation. This study aims to evaluate the effects of two personalized energy-restricted diets on the liver status in overweight or obese subjects with NAFLD after a 6 months follow-up. Ninety-eight individuals from the Fatty Liver in Obesity (FLiO) study were randomized into two groups and followed different energy-restricted diets. Subjects were evaluated at baseline and after 6 months. Diet, anthropometry, body composition, and biochemical parameters were evaluated. Liver assessment included ultrasonography, Magnetic Resonance Imaging, elastography, and determination of transaminases. Both dietary groups significantly improved their metabolic and hepatic markers after the intervention, with no significant differences between them. Multivariate regression models evidenced a relationship between weight loss, adherence to the Mediterranean Diet (MedDiet), and a decrease in liver fat content, predicting up to 40.9% of its variability after 6 months. Moreover, the antioxidant capacity of the diet was inversely associated with liver fat content. Participants in the group with a higher adherence to the MedDiet showed a greater reduction in body weight, total fat mass, and hepatic fat. These results support the benefit of energy-restricted diets, high adherence to the MedDiet, and high antioxidant capacity of the diet for the management of NAFLD in individuals with overweight or obesity. C1 [Araceli Marin-Alejandre, Bertha; Abete, Itziar; Cantero, Irene; Alfredo Martinez, J.; Angeles Zulet, M.] Univ Navarra, Fac Pharm & Nutr, Dept Nutr Food Sci & Physiol, Pamplona 31008, Spain. [Araceli Marin-Alejandre, Bertha; Abete, Itziar; Cantero, Irene; Alfredo Martinez, J.; Angeles Zulet, M.] Univ Navarra, Fac Pharm & Nutr, Ctr Nutr Res, Pamplona 31008, Spain. [Abete, Itziar; Tur, Josep A.; Alfredo Martinez, J.; Angeles Zulet, M.] Inst Salud Carlos III, Biomed Res Ctr Network Physiopathol Obes & Nutr C, Madrid 28029, Spain. [Ignacio Monreal, J.; Elorz, Mariana; Ignacio Herrero, Jose; Benito-Boillos, Alberto; Quiroga, Jorge; Martinez-Echeverria, Ana; Isidro Uriz-Otano, Juan; Pilar Huarte-Muniesa, Maria; Alfredo Martinez, J.; Angeles Zulet, M.] Navarra Inst Hlth Res IdiSNA, Pamplona 31008, Spain. [Ignacio Monreal, J.] Clin Univ Navarra, Clin Chem Dept, Pamplona 31008, Spain. [Elorz, Mariana; Benito-Boillos, Alberto] Clin Univ Navarra, Dept Radiol, Pamplona 31008, Spain. [Ignacio Herrero, Jose] Clin Univ Navarra, Liver Unit, Pamplona 31008, Spain. [Ignacio Herrero, Jose; Quiroga, Jorge] Ctr Invest Biomed Red Enfermedades Hepat & Digest, Madrid 28029, Spain. [Quiroga, Jorge] Clin Univ Navarra, Dept Internal Med, Pamplona 31008, Spain. [Martinez-Echeverria, Ana; Isidro Uriz-Otano, Juan; Pilar Huarte-Muniesa, Maria] Complejo Hosp Navarra, Dept Gastroenterol, Pamplona 31008, Spain. [Tur, Josep A.] Univ Balearic Isl, Res Grp Community Nutr & Oxidat Stress, Palma De Mallorca 07122, Spain. C3 University of Navarra; University of Navarra; Instituto de Salud Carlos III; University of Navarra; University of Navarra; University of Navarra; University of Navarra; CIBER - Centro de Investigacion Biomedica en Red; CIBEREHD; University of Navarra; Servicio Navarro de Salud - Osasunbidea; Universitat de les Illes Balears RP Martinez, JA; Zulet, MA (通讯作者)，Univ Navarra, Fac Pharm & Nutr, Dept Nutr Food Sci & Physiol, Pamplona 31008, Spain.; Martinez, JA; Zulet, MA (通讯作者)，Univ Navarra, Fac Pharm & Nutr, Ctr Nutr Res, Pamplona 31008, Spain.; Martinez, JA; Zulet, MA (通讯作者)，Inst Salud Carlos III, Biomed Res Ctr Network Physiopathol Obes & Nutr C, Madrid 28029, Spain.; Martinez, JA; Zulet, MA (通讯作者)，Navarra Inst Hlth Res IdiSNA, Pamplona 31008, Spain. EM bmarin.1@alumni.unav.es; iabetego@unav.es; icgonzalez@unav.es; jimonreal@unav.es; marelorz@unav.es; iherrero@unav.es; albenitob@unav.es; jquiroga@unav.es; ana.martinez.echeverria@cfnavarra.es; jurizota@cfnavarra.es; phuartem@cfnavarra.es; pep.tur@uib.es; jalfmtz@unav.es; mazulet@unav.es RI Tur, Josep/AAE-5748-2020; Abete, Itziar/H-4827-2017; Benito, Alberto/AAD-4201-2020; Zulet, M Angeles/H-1317-2017; Carlón, Mariana/ABD-5128-2021 OI Tur, Josep/0000-0002-6940-0761; Herrero, J Ignacio/0000-0002-9076-6717; Abete, Itziar/0000-0002-6475-5387; Quiroga, Jorge/0000-0003-2789-6735; Benito, Alberto/0000-0002-1527-0092; Elorz Carlón, Mariana/0000-0002-1580-3629; Zulet, M Angeles/0000-0002-3926-0892; Marín Alejane, Bertha Araceli/0000-0003-0741-8197; FU Health Department of the Government of Navarra [61/2015]; CIBERobn (Physiopathology of Obesity and Nutrition); FundaciO La MaratO de TV3 [201630.10]; Consejo Nacional de Ciencia y Tecnologia (CONACYT) y el Estado de Michoacan [440104/2016] FX This research was funded by the Health Department of the Government of Navarra (61/2015), CIBERobn (Physiopathology of Obesity and Nutrition) and FundaciO La MaratO de TV3 (201630.10). B.A.M.-A. was supported by fellowships from Consejo Nacional de Ciencia y Tecnologia (CONACYT) y el Estado de Michoacan (440104/2016). 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After excluding factors affecting the diagnosis of hepatic steatosis, 727 adults were analyzed as part of the Health Promotion Project. The dietary patterns of the participants were classified into rice, vegetable, seafood, and sweet based on their daily food intake. Liver stiffness measurements and controlled attenuation parameters were performed using FibroScan. Energy and nutrient intake were calculated using the Brief-type Self-administered Diet History Questionnaire. Univariate and multivariate analyses were used to identify the risk factors for liver fibrosis within the MASLD population. The vegetable group had significantly lower liver fibrosis indicators in the MASLD population than the rice group. The multivariate analysis identified a body mass index >= 25 kg/m(2) (odds ratio [OR], 1.83; 95% confidence interval [CI], 1.01-1.83; p = 0.047) and HOMA-IR >= 1.6 (OR, 3.18; 95% CI, 1.74-5.78; p < 0.001) as risk factors for liver fibrosis, and vegetable group membership was a significant low-risk factor (OR, 0.38; 95% CI, 0.16-0.88; p = 0.023). The multivariate analysis of nutrients in low-risk foods revealed high intake of alpha-tocopherol (OR, 0.74; 95% CI, 0.56-0.99; p = 0.039) as a significant low-risk factor for liver fibrosis. This study suggests that a vegetable-based Japanese dietary pattern, through the antioxidant effects of alpha-tocopherol, may help prevent liver fibrosis in MASLD and the development of MASLD. C1 [Sasada, Takafumi; Iino, Chikara; Sato, Satoshi; Tateda, Tetsuyuki; Igarashi, Go; Yoshida, Kenta; Sakuraba, Hirotake; Fukuda, Shinsaku] Hirosaki Univ, Grad Sch Med, Dept Surg Gastroenterol, Hirosaki, Aomori 0368562, Japan. [Sawada, Kaori; Mikami, Tatsuya; Nakaji, Shigeyuki] Hirosaki Univ, Grad Sch Med, Dept Preempt Med, Hirosaki 0368562, Japan. C3 Hirosaki University; Hirosaki University RP Iino, C (通讯作者)，Hirosaki Univ, Grad Sch Med, Dept Surg Gastroenterol, Hirosaki, Aomori 0368562, Japan. EM ssd.tkfm@hirosaki-u.ac.jp; chikaran0601@hirosaki-u.ac.jp; satoshis@hirosaki-u.ac.jp; tsuyuki31@gmail.com; goigarashi19820910@hotmail.co.jp; kyoshida@hirosaki-u.ac.jp; iwane@hirosaki-u.ac.jp; tmika@hirosaki-u.ac.jp; nakaji@hirosaki-u.ac.jp; hirotake@hirosaki-u.ac.jp; sfukuda@hirosaki-u.ac.jp RI Iino, Chikara/I-8730-2019; Yoshida, Kenta/MCJ-0506-2025 OI Nakaji, Shigeyuki/0000-0002-4190-5151; Sato, Satoshi/0000-0001-5569-7093; Yoshida, Kenta/0000-0002-3897-5546 FU JST COI; [JPMJCE1302]; [PPMJCA2201]; [JPMJP2210]; Grants-in-Aid for Scientific Research [23K07451, 22K17386] Funding Source: KAKEN FX This work was supported by JST COI, numbers JPMJCE1302, PPMJCA2201, and JPMJP2210. 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Georgousopoulou, Ekavi N. Mellor, Duane D. Chrysohoou, Christina Pitsavos, Christos Panagiotakos, Demosthenes B. TI Exploring the Path of Mediterranean Diet, Non-Alcoholic Fatty Liver Disease (NAFLD) and Inflammation towards 10-Year Cardiovascular Disease (CVD) Risk: The ATTICA Study 10-Year Follow-Up (2002-2012) SO NUTRIENTS LA English DT Article DE Mediterranean diet; non-alcoholic fatty liver disease; fatty liver index; inflammation; cardiovascular disease; cardiovascular risk ID HEALTHY-ADULTS; PREVALENCE; ADHERENCE; EPIDEMIOLOGY; PATHOGENESIS; MANAGEMENT; SEVERITY AB Background: Non-alcoholic fatty liver disease (NAFLD) is the leading cause of liver disease, affecting similar to 30% of the population and increasing CVD. This study aimed to explore the direct, indirect and combined effects of Mediterranean diet, NAFLD and inflammation on the 10-year CVD risk in a healthy adult population. Methods: Using baseline and 10-year follow-up data from the ATTICA study, adherence to Mediterranean diet was measured using MedDietScore, and presence of NAFLD at baseline was assessed using the fatty liver index (FLI). Participants' 10-year CVD outcomes were recorded and C-reactive protein (CRP) was used as a surrogate marker for inflammation. The direct and indirect roles of these factors were explored using logistic regression models and the pathways between them were analysed using a structural equation model (SEM). Results: NAFLD prevalence was 22.9% and its presence was 17% less likely for every unit increase in MedDietScore. NAFLD presence at baseline was associated with increased 10-year CVD incidence (39.4% vs. 14.5%, p = 0.002), but when adjusted for MedDietScore, NAFLD was not an independent predictor of 10-year CVD risk. MedDietScore was an independent protective factor of 10-year CVD risk (OR = 0.989, 95% CI: 0.847, 0.935), when adjusted for NAFLD at baseline, age, gender, sedentary lifestyle and other confounders. Further exploration using SEM showed that MedDietScore was associated with CVD risk directly even when inflammation as CRP was introduced as a potential mediator. Conclusion: FLI as a proxy measure of NAFLD is a strong predictor of 10-year CVD risk, and this prognostic relationship seems to be moderated by the level of adherence to Mediterranean diet. Adherence to Mediterranean diet remained an independent and direct CVD risk factor irrespective of NAFLD status and CRP. C1 [George, Elena S.] Deakin Univ, Inst Phys Act & Nutr, Sch Exercise & Nutr Sci, Geelong, Vic 2600, Australia. [Georgousopoulou, Ekavi N.] Australian Natl Univ, Med Sch, Canberra, ACT 2601, Australia. [Georgousopoulou, Ekavi N.] Univ Notre Dame Australia, Sch Med, Darlinghurst, NSW 2010, Australia. [Georgousopoulou, Ekavi N.] ACT Hlth Directorate, Ctr Hlth & Med Res, Canberra, ACT 2601, Australia. [Mellor, Duane D.] Aston Univ, Aston Med Sch, Birmingham B4 7ET, W Midlands, England. [Chrysohoou, Christina; Pitsavos, Christos] Natl Kapodistrian Univ Athens, Cardiol Clin 1, Athens Med Sch, Athens 10679, Greece. [Panagiotakos, Demosthenes B.] Harokopio Univ, Sch Hlth & Educ, Dept Nutr & Dietet, 46 Paleon Polemiston St, Athens 16674, Greece. C3 Deakin University; Australian National University; The University of Notre Dame Australia; University of Notre Dame Australia - Sydney; University of Notre Dame Australia - Sydney Campus Darlinghurst; National & Kapodistrian University of Athens; Harokopio University Athens RP Panagiotakos, DB (通讯作者)，Harokopio Univ, Sch Hlth & Educ, Dept Nutr & Dietet, 46 Paleon Polemiston St, Athens 16674, Greece. EM elena.george@deakin.edu.au; ekavi.georgousopoulou@nd.edu.au; d.mellor@aston.ac.uk; chrysohoou@usa.net; greece.xlipidepart@internet.gr; dbpanag@hua.gr RI Panagiotakos, Demosthenes/K-8294-2019; Georgousopoulou, Ekavi/AAC-2563-2019; Mellor, Duane/H-1262-2012; George, Elena/J-3357-2019 OI Chrysohoou, Christina/0000-0002-6340-3996; Mellor, Duane/0000-0002-1369-3868; George, Elena/0000-0002-1385-2371 FU Hellenic Cardiology Society [HCS2002]; Hellenic Atherosclerosis Society [HAS2003]; Coca-Cola Company; Cobram Estate FX The ATTICA study is supported by research grants from the Hellenic Cardiology Society (HCS2002) and the Hellenic Atherosclerosis Society (HAS2003). Demosthenes Panagiotakos and Ekavi Georgousopoulou have received research grants from the Coca-Cola Company. Elena George is an expert advisor for the Olive Wellness Institute and has received funds from Cobram Estate. 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Shaheen, Abdel Aziz TI Dietary Patterns and Components in Nonalcoholic Fatty Liver Disease (NAFLD): What Key Messages Can Health Care Providers Offer? SO NUTRIENTS LA English DT Review DE non-alcoholic fatty liver disease; Mediterranean diet; lifestyle change; weight loss ID LIFE-STYLE MODIFICATION; NUTRITION EXAMINATION SURVEY; WEIGHT-LOSS; PHYSICAL-ACTIVITY; METABOLIC SYNDROME; ALANINE AMINOTRANSFERASE; CARDIOVASCULAR-DISEASE; PRACTICE GUIDELINES; MEDITERRANEAN DIET; INSULIN-RESISTANCE AB Nonalcoholic fatty liver disease (NAFLD) is a rising epidemic worldwide and will be the leading cause of cirrhosis, hepatocellular carcinoma, and liver transplant within the next decade. NAFLD is considered as the hepatic manifestation of metabolic syndrome. Behaviors, such as a sedentary lifestyle and consuming a Western diet, have led to substantial challenges in managing NAFLD patients. With no curative pharmaceutical therapies, lifestyle modifications, including dietary changes and exercise, that ultimately lead to weight loss remain the only effective therapy for NAFLD. Multiple diets, including low-carbohydrate, low-fat, Dietary Approaches to Stop Hypertension (DASH), and Mediterranean (MD) diets, have been evaluated. NAFLD patients have shown better outcomes with a modified diet, such as the MD diet, where patients are encouraged to increase the consumption of fruits and vegetables, whole grains, and olive oil. It is increasingly clear that a personalized approach to managing NAFLD patients, based on their preferences and needs, should be implemented. In our review, we cover NAFLD management, with a specific focus on dietary patterns and their components. We emphasize the successful approaches highlighted in recent studies to provide recommendations that health care providers could apply in managing their NAFLD patients. C1 [Riazi, Kiarash; Raman, Maitreyi; Taylor, Lorian; Swain, Mark G.; Shaheen, Abdel Aziz] Univ Calgary, Dept Med, Div Gastroenterol & Hepatol, Calgary, AB T2N 4Z6, Canada. [Shaheen, Abdel Aziz] Univ Calgary, Community Hlth Sci, OBrien Inst Publ Hlth, Cumming Sch Med, 3280 Hosp Dr NW, Calgary, AB T2N 4Z6, Canada. C3 University of Calgary; University of Calgary RP Shaheen, AA (通讯作者)，Univ Calgary, Dept Med, Div Gastroenterol & Hepatol, Calgary, AB T2N 4Z6, Canada.; Shaheen, AA (通讯作者)，Univ Calgary, Community Hlth Sci, OBrien Inst Publ Hlth, Cumming Sch Med, 3280 Hosp Dr NW, Calgary, AB T2N 4Z6, Canada. EM kriazi@ucalgary.ca; mkothand@ucalgary.ca; lorian.taylor@ucalgary.ca; swain@ucalgary.ca; az.shaheen@ucalgary.ca RI Shaheen, Abdel/AAX-3773-2021 OI Raman, Maitreyi/0000-0002-9129-3632; Riazi, Kiarash/0000-0002-2291-7405 FU Canadian Institutes of Health Research (CIHR) [PJT-165848] FX This research was funded by the Canadian Institutes of Health Research (CIHR), project grant number "PJT-165848". 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Lukas, A Gramlinger, K Julian, V Thivel, D Mörwald, K Maruszczak, K Mangge, H Gomahr, J Weghuber, D Furthner, D AF Pixner, Thomas Stummer, Nathalie Schneider, Anna Maria Lukas, Andreas Gramlinger, Karin Julian, Valerie Thivel, David Moerwald, Katharina Maruszczak, Katharina Mangge, Harald Gomahr, Julian Weghuber, Daniel Furthner, Dieter TI The Role of Macronutrients in the Pathogenesis, Prevention and Treatment of Non-Alcoholic Fatty Liver Disease (NAFLD) in the Paediatric Population-A Review SO LIFE-BASEL LA English DT Review DE paediatric; non-alcoholic fatty liver disease; NAFLD; macronutrients; obesity; carbohydrates; fat; protein; nutrition; diet ID LIFE-STYLE INTERVENTION; CARDIOMETABOLIC RISK-FACTORS; SUGAR-SWEETENED BEVERAGES; LOW-DENSITY-LIPOPROTEIN; SOFT DRINK CONSUMPTION; DE-NOVO LIPOGENESIS; BODY-MASS INDEX; METABOLIC SYNDROME; MEDITERRANEAN DIET; INSULIN SENSITIVITY AB Paediatric non-alcoholic fatty liver disease (NAFLD) has become the most common chronic liver disease in childhood. Obesity is the main risk factor. Nutrition and lifestyle are the key elements in preventing and treating NAFLD in the absence of approved drug therapy. Whilst recommendations and studies on macronutrients (carbohydrates, fat and protein) in adult NAFLD exist, the discussion of this topic in paediatric NAFLD remains contradictory. The purpose of this review is to provide state-of-the-art knowledge on the role of macronutrients in paediatric NAFLD regarding quality and quantity. PubMed was searched and original studies and review articles were included in this review. Fructose, sucrose, saturated fatty acids, trans-fatty acids and omega-6-fatty-acids are strongly associated with paediatric NAFLD. High consumption of fibre, diets with a low glycaemic index, mono-unsaturated-fatty-acids and omega-3-fatty-acids reduce the risk of childhood-onset NAFLD. Data regarding the role of dietary protein in NAFLD are contradictory. No single diet is superior in treating paediatric NAFLD, although the composition of macronutrients in the Mediterranean Diet appears beneficial. Moreover, the optimal proportions of total macronutrients in the diet of paediatric NAFLD patients are unknown. Maintaining a eucaloric diet and avoiding saturated fatty acids, simple sugars (mainly fructose) and a high-caloric Western Diet are supported by literature. C1 [Pixner, Thomas; Lukas, Andreas; Gramlinger, Karin; Furthner, Dieter] Salzkammergutklinikum Voecklabruck, Dept Paediat & Adolescent Med, A-4840 Voecklabruck, Austria. [Pixner, Thomas; Stummer, Nathalie; Schneider, Anna Maria; Lukas, Andreas; Moerwald, Katharina; Maruszczak, Katharina; Gomahr, Julian; Weghuber, Daniel; Furthner, Dieter] Paracelsus Med Univ, Obes Res Unit, A-5020 Salzburg, Austria. [Stummer, Nathalie; Schneider, Anna Maria; Moerwald, Katharina; Maruszczak, Katharina; Gomahr, Julian; Weghuber, Daniel] Paracelsus Med Univ, Dept Paediat, A-5020 Salzburg, Austria. [Julian, Valerie] Univ Clermont Auvergne, Univ Teaching Hosp Clermont Ferrand, INRA,Diet & Musculoskeletal Hlth Team, Human Nutr Res Ctr CRNH,Dept Sport Med & Funct Ex, F-63000 Clermont Ferrand, France. [Thivel, David] Univ Clermont Auvergne, Lab Metab Adaptat Exercise Physiol & Pathol Condi, F-63000 Clermont Ferrand, France. [Mangge, Harald] Med Univ Graz, Clin Inst Med & Chem Lab Diagnost, A-8010 Graz, Austria. C3 Paracelsus Private Medical University; Paracelsus Private Medical University; Universite Clermont Auvergne (UCA); CHU Clermont Ferrand; INRAE; Universite Clermont Auvergne (UCA); Medical University of Graz RP Weghuber, D (通讯作者)，Paracelsus Med Univ, Obes Res Unit, A-5020 Salzburg, Austria.; Weghuber, D (通讯作者)，Paracelsus Med Univ, Dept Paediat, A-5020 Salzburg, Austria. 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Mediterranean Diet and Antioxidant Formulation in Non-Alcoholic Fatty Liver Disease: A Randomized Study SO NUTRIENTS LA English DT Article DE non-alcoholic fatty liver disease; Mediterranean diet; insulin resistance; weight; antioxidant ID E-PHOSPHOLIPID COMPLEX; VITAMIN-E; INSULIN-RESISTANCE; LIPID-PEROXIDATION; METABOLIC SYNDROME; STEATOHEPATITIS; INTERVENTION; EPIDEMIOLOGY; GLUCOSE; TARGET AB Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease worldwide, characterized by liver fatty acid accumulation and fibrosis, not due to excessive alcohol consumption. Notably, nutritional habits have been reported to be implicated in the onset and severity of the hepatic damage, while the Mediterranean diet has shown beneficial effects on NAFLD. Free radicals and oxidative stress were suggested to be involved in the pathogenesis and progression of NAFLD, and several data highlighted the efficacy of antioxidant supplementation in its treatment. The aim of this study was to compare the effects of the Mediterranean diet, with or without an antioxidant complex supplement, in overweight patients suffering from NAFLD. In this prospective study, fifty Caucasian overweight patients were randomized into three groups (Groups A-C). A personalized moderately hypocaloric Mediterranean diet was prescribed to all patients included in the A and B groups. In addition to the diet, Group B was administered antioxidant supplementation daily and for the period of six months. Group C did not have any type of treatment. The study proved that the Mediterranean diet alone or in association with the antioxidant complex improved anthropometric parameters, lipid profile and reduced hepatic fat accumulation and liver stiffness. However, Group B patients, in which the diet was associated with antioxidant intake, showed not only a significant improvement in insulin sensitivity, but also a more consistent reduction of anthropometric parameters when compared with Group A patients. Taken together, these results support the benefit of antioxidant supplementation in overweight patients with NAFLD. C1 [Abenavoli, Ludovico; Greco, Marta; Accattato, Francesca; Foti, Daniela; Gulletta, Elio; Luzza, Francesco] Magna Graecia Univ Catanzaro, Dept Hlth Sci, I-88100 Catanzaro, Italy. [Milic, Natasa] Univ Novi Sad, Dept Pharm, Novi Sad 21000, Serbia. C3 Magna Graecia University of Catanzaro; University of Novi Sad RP Abenavoli, L (通讯作者)，Magna Graecia Univ Catanzaro, Dept Hlth Sci, I-88100 Catanzaro, Italy. 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28805669 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Chooi, YC Magkos, F Yaligar, J Michael, N Sadananthan, SA Kway, YM Velan, SS Lim, KJ Lai, XN Wong, LH Chong, YS Loo, EXL Eriksson, JG AF Chooi, Yu Chung Magkos, Faidon Yaligar, Jadegoud Michael, Navin Sadananthan, Suresh Anand Kway, Yeshe Manuel Velan, S. Sendhil Lim, Kevin Junliang Lai, Xianning Wong, Long Hui Chong, Yap Seng Loo, Evelyn Xiu Ling Eriksson, Johan G. TI Adherence to a "MediterrAsian" diet is associated with weight loss-independent improvements in liver fat and lipid profile, but not glucoregulation or inflammation: secondary analysis of a randomized controlled trial SO FRONTIERS IN NUTRITION LA English DT Article DE diet quality; diet treatment; intrahepatic triglyceride; non-alcoholic fatty liver disease; metabolic dysfunction-associated steatotic liver disease ID DISEASE NAFLD; GROWTH-FACTOR; INTERVENTION; EPIDEMIOLOGY; CONSUMPTION; ADULTS; VEGF; HGF AB Background Greater adherence to the Mediterranean Diet (MedDiet) has been associated with improved inflammatory biomarkers in Western populations, suggesting that the anti-inflammatory effect is crucial for improvements in body weight, body composition, and cardiometabolic risk factors observed with the MedDiet. We previously reported that a calorie-restricted MedDiet adapted to the Asian food culture has beneficial effects on body composition, liver fat, and cardiometabolic risk markers in Chinese women with fatty liver disease.Objective To evaluate the effects of MedDiet on inflammation and examine the relationship between dietary adherence and changes in health outcomes.Methods 88 non-diabetic Chinese women with fatty liver who participated in a 3-arm, 12-week dietary randomized controlled trial were included in this secondary analysis. Adherence to the MedDiet was assessed using a validated questionnaire. Correlation analysis was performed to identify the relationships between changes in total and food group-specific MedDiet scores and changes in anthropometric measures, body fat percentage, liver fat, muscle and abdominal fat, as well as cardiometabolic and inflammation markers from baseline to post-intervention. Analyses were conducted both without adjustments and after adjusting for weight change.Results Body weight, total body fat, visceral and subcutaneous adipose tissues, and liver fat decreased significantly after the intervention, in tandem with improvements in markers of glucose and lipid metabolism and inflammation. The change in MedDiet scores (total and individual food groups) correlated with changes in liver fat and improvements in lipid profile, but not with changes in measures of glucose regulation and inflammation after adjusting for changes in body weight. Increased intake of vegetables, nuts, fish, legumes and olive oil appears to be the main driver of these associations.Conclusion Greater adherence to the MedDiet among nondiabetic Asian women with fatty liver is associated with greater improvements in hepatic fat and lipid profile, but the association with glucose regulation and inflammation is less pronounced. It thus remains unclear whether resolution of inflammation is the key mechanism for the health benefits of MedDiet.Clinical trial registration clinicaltrials.gov, identifier [NCT05259475]. C1 [Chooi, Yu Chung; Yaligar, Jadegoud; Michael, Navin; Sadananthan, Suresh Anand; Kway, Yeshe Manuel; Velan, S. Sendhil; Chong, Yap Seng; Loo, Evelyn Xiu Ling; Eriksson, Johan G.] ASTAR, Inst Human Dev & Potential IHDP, Singapore, Singapore. [Magkos, Faidon] Univ Copenhagen, Dept Nutr Exercise & Sports, Frederiksberg, Denmark. [Kway, Yeshe Manuel] Natl Univ Singapore NUS, Yong Loo Lin Sch Med, Dept Med, Singapore, Singapore. [Lim, Kevin Junliang; Lai, Xianning; Wong, Long Hui] Natl Univ Singapore NUS, Ctr Translat Med, WIL NUS Corp Lab, Singapore, Singapore. [Chong, Yap Seng; Eriksson, Johan G.] Natl Univ Singapore NUS, Yong Loo Lin Sch Med, Dept Obstet & Gynaecol, Singapore, Singapore. [Loo, Evelyn Xiu Ling] Natl Univ Singapore NUS, Yong Loo Lin Sch Med, Dept Paediat, Human Potential Translat Res Programme, Singapore, Singapore. [Eriksson, Johan G.] Univ Helsinki, Dept Gen Practice & Primary Hlth Care, Helsinki, Finland. [Eriksson, Johan G.] Helsinki Univ Hosp, Helsinki, Finland. [Eriksson, Johan G.] Folkhalsan Res Ctr, Helsinki, Finland. [Velan, S. Sendhil] Univ Massachusetts Amherst, Inst Appl Life Sci, Human Magnet Resonance Ctr, Amherst, MA USA. C3 Agency for Science Technology & Research (A*STAR); University of Copenhagen; National University of Singapore; National University of Singapore; National University of Singapore; National University of Singapore; University of Helsinki; University of Helsinki; Helsinki University Central Hospital; Folkhalsan Research Center; University of Massachusetts System; University of Massachusetts Amherst RP Chooi, YC; Eriksson, JG (通讯作者)，ASTAR, Inst Human Dev & Potential IHDP, Singapore, Singapore.; Eriksson, JG (通讯作者)，Natl Univ Singapore NUS, Yong Loo Lin Sch Med, Dept Obstet & Gynaecol, Singapore, Singapore.; Eriksson, JG (通讯作者)，Univ Helsinki, Dept Gen Practice & Primary Hlth Care, Helsinki, Finland.; Eriksson, JG (通讯作者)，Folkhalsan Res Ctr, Helsinki, Finland. EM chooiyc@sics.a-star.edu.sg; obgjge@nus.edu.sg RI Magkos, Faidon/CAA-9939-2022; Velan, S Sendhil/B-6374-2017; Michael, Navin/HGF-2322-2022 OI Magkos, Faidon/0000-0002-1312-7364; Velan, S Sendhil/0000-0002-4096-0722; FU Agency for Science, Technology and Research (A*STAR) under its Industry Alignment Fund -Industry Collaboration Project (IAF-ICP) [I1701E0011] FX The author(s) declare that financial support was received for the research and/or publication of this article. This research was supported by Agency for Science, Technology and Research (A*STAR) under its Industry Alignment Fund -Industry Collaboration Project (IAF-ICP) funding (Award number I1701E0011). 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PD JUL 24 PY 2025 VL 12 AR 1623612 DI 10.3389/fnut.2025.1623612 PG 10 WC Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Nutrition & Dietetics GA 5VP0P UT WOS:001545380500001 PM 40777170 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Mercurio, G Giacco, A Scopigno, N Vigliotti, M Goglia, F Cioffi, F Silvestri, E AF Mercurio, Giovanna Giacco, Antonia Scopigno, Nicla Vigliotti, Michela Goglia, Fernando Cioffi, Federica Silvestri, Elena TI Mitochondria at the Crossroads: Linking the Mediterranean Diet to Metabolic Health and Non-Pharmacological Approaches to NAFLD SO NUTRIENTS LA English DT Review DE mitochondrial bioenergetics; mitochondrial quality control; polyphenols; MUFA; PUFA; fructose; fatty liver; metabolic syndrome; lifestyle; MASLD ID NONALCOHOLIC FATTY LIVER; DE-NOVO LIPOGENESIS; INSULIN-RESISTANCE; OLIVE OIL; HEPATIC STEATOSIS; ENERGY-METABOLISM; OBETICHOLIC ACID; OXIDATIVE STRESS; FOOD-PRODUCTS; DISEASE AB Nonalcoholic fatty liver disease (NAFLD) is a growing global health concern that is closely linked to metabolic syndrome, yet no approved pharmacological treatment exists. The Mediterranean diet (MD) emerged as a first-line dietary intervention for NAFLD, offering metabolic and hepatoprotective benefits. Now conceptualized as a complex chemical matrix rich in bioactive compounds, the MD exerts antioxidant and anti-inflammatory effects, improving insulin sensitivity and lipid metabolism. Mitochondria play a central role in NAFLD pathophysiology, influencing energy metabolism, oxidative stress, and lipid homeostasis. Emerging evidence suggests that the MD's bioactive compounds enhance mitochondrial function by modulating oxidative phosphorylation, biogenesis, and mitophagy. However, most research has focused on individual compounds rather than the MD as a whole, leaving gaps in understanding its collective impact as a complex dietary pattern. This narrative review explores how the MD and its bioactive compounds influence mitochondrial health in NAFLD, highlighting key pathways such as mitochondrial substrate control, dynamics, and energy efficiency. A literature search was conducted to identify relevant studies on the MD, mitochondria, and NAFLD. While the search was promising, our understanding remains incomplete, particularly when current knowledge is limited by the lack of mechanistic and comprehensive studies on the MD's holistic impact. Future research integrating cutting-edge experimental approaches is needed to elucidate the intricate diet-mitochondria interactions. A deeper understanding of how the MD influences mitochondrial health in NAFLD is essential for developing precision-targeted nutritional strategies that can effectively prevent and manage the disease. C1 [Mercurio, Giovanna; Giacco, Antonia; Scopigno, Nicla; Vigliotti, Michela; Goglia, Fernando; Cioffi, Federica; Silvestri, Elena] Univ Sannio, Dept Sci & Technol, Via Sanctis, I-82100 Benevento, Italy. C3 University of Sannio RP Silvestri, E (通讯作者)，Univ Sannio, Dept Sci & Technol, Via Sanctis, I-82100 Benevento, Italy. EM giomercurio@unisannio.it; antonia.giacco@unisannio.it; n.scopigno@studenti.unisannio.it; mvigliotti@unisannio.it; goglia@unisannio.it; fecioffi@unisannio.it; silvestri@unisannio.it RI ; cioffi, federica/AAB-8161-2019 OI Mercurio, Giovanna/0009-0007-5112-5881; FU Nutraceutica, nutrigenomica e alimenti funzionali; ISTITUTO NEUROLOGICO MEDITERRANEO; Creazione di un programma di azione per la lotta alla malnutrizione in tutte le sue forme e per la diffusione dei principi della dieta mediterranea [CUP: F83C22002080008] FX This research was funded by "Nutraceutica, nutrigenomica e alimenti funzionali", ISTITUTO NEUROLOGICO MEDITERRANEO "NEUROMED S.p.A", Traiettoria 5, Azione 5.1, << Creazione di un programma di azione per la lotta alla malnutrizione in tutte le sue forme e per la diffusione dei principi della dieta mediterranea >> -UOR UNISANNIO (CUP: F83C22002080008). 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Dalbeni, Andrea TI Treatments for NAFLD: State of Art SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES LA English DT Review DE non-alcoholic fatty liver disease; NAFLD; non-alcoholic steatohepatitis; metabolic associated fatty liver disease; MAFLD ID FATTY LIVER-DISEASE; PLACEBO-CONTROLLED TRIAL; NONALCOHOLIC STEATOHEPATITIS; MEDITERRANEAN DIET; HEPATIC STEATOSIS; CARDIOVASCULAR-DISEASE; RECEPTOR BLOCKER; OBETICHOLIC ACID; VITAMIN-E; PIOGLITAZONE AB Non-alcoholic fatty liver disease (NAFLD) is to date the most common chronic liver disease in clinical practice and, consequently, a major health problem worldwide. It affects approximately 30% of adults in the general population and up to 70% of patients with type 2 diabetes (T2DM). Despite the current knowledge of the epidemiology, pathogenesis, and natural history of NAFLD, no specific pharmacological therapies are until now approved for this disease and, consequently, general strategies have been proposed to manage it. They include: (a) lifestyle change in order to promote weight loss by diet and physical activity, (b) control of the main cardiometabolic risk factors, (c) correction of all modifiable risk factors leading the development and progression of advanced forms of NAFLD, and (d) prevention of hepatic and extra-hepatic complications. In the last decade, several potential agents have been widely investigated for the treatment of NAFLD and its advanced forms-shedding some light but casting a few shadows. They include some glucose-lowering drugs (such as pioglitazone, glucagon-like peptide-1 (GLP-1) receptor agonists, sodium-glucose co-transporter-2 (SGLT-2) inhibitors), antioxidants (such as vitamin E), statins or other lipid lowering agents, bile and non-bile acid farnesoid X activated receptor (FXR) agonists, and others. This narrative review discusses in detail the different available approaches with the potential to prevent and treat NAFLD and its advanced forms. C1 [Mantovani, Alessandro] Univ Verona, Sect Endocrinol Diabet & Metab, I-37126 Verona, Italy. [Mantovani, Alessandro] Azienda Osped Univ Integrata Verona, I-37126 Verona, Italy. [Dalbeni, Andrea] Univ Verona, Sect Gen Med, Hypertens & Liver Unit, I-37134 Verona, Italy. [Dalbeni, Andrea] Azienda Osped Univ Integrata Verona, I-37134 Verona, Italy. 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J. Mol. Sci. PD MAR PY 2021 VL 22 IS 5 AR 2350 DI 10.3390/ijms22052350 PG 25 WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary WE Science Citation Index Expanded (SCI-EXPANDED) SC Biochemistry & Molecular Biology; Chemistry GA QV9CY UT WOS:000628261500001 PM 33652942 OA Green Submitted, gold DA 2026-02-02 ER PT J AU García, S Bouzas, C Ródenas-Munar, M Cepeda, V Ugarriza, L Casares, M Gómez, C Mateos, D Tur, JA AF Garcia, Silvia Bouzas, Cristina Rodenas-Munar, Marina Cepeda, Violeta Ugarriza, Lucia Casares, Miguel Gomez, Cristina Mateos, David Tur, Josep A. TI Metabolic Dysfunction-Associated Steatotic Liver Disease Is Linked to Environmental Sustainability: The Role of the Mediterranean Diet SO NUTRIENTS LA English DT Article DE Mediterranean diet; intrahepatic fat content; MASLD; environmental impact; sustainability ID FOOD-FREQUENCY QUESTIONNAIRE; DIOXIDE CO2 EMISSIONS; ADHERENCE; POPULATION; VALIDATION; VALIDITY; IMPACTS; HEALTH; MEAT AB Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) and climate change are major global health challenges. Aim: Our aim was to assess the relationship between intrahepatic fat content (IFC) and diet-related environmental impact in a Mediterranean diet (MD)-based intervention. Design: The design included a six-month longitudinal analysis within the frame of a FLIPAN randomized controlled trial, including 60 participants aged 40-60 years with MASLD, metabolic syndrome and obesity. Methods: IFC expressed as a percentage (%IFC) was measured by magnetic resonance imaging, and dietary intake was assessed via a validated food frequency questionnaire (FFQ). Environmental impacts of diets were estimated using life cycle assessment data from the Agribalyse (R) database, focusing on greenhouse gas (GHG) emissions, water use, energy use and land use. A composite sustainability score was also calculated. Changes in liver fat and environmental footprints were analyzed using a general linear model (GLM) adjusted for within-subject variability and partial correlation analysis adjusted for energy intake, MD adherence and body weight. Results: The participants with the highest %IFC reduction group in the GLM showed the highest decreases in GHG emissions and land use. Water use increased in this same group. Energy use and the composite sustainability score did not differ significantly between groups. Higher %IFC reductions were also associated with higher MD adherence and lower visceral fat. When the adjusted partial correlation analysis for the environmental parameters was performed, only water use remained significant. Conclusions: Higher reductions in %IFC were linked to dietary patterns with lower GHG emissions and land use and higher water use. However, when adjusted by energy intake, MD adherence and body weight in continuous modeling, only higher water use was related to lower %IFC. These findings highlight the complexity of achieving environmentally sustainable and health-promoting diets. C1 [Garcia, Silvia; Bouzas, Cristina; Rodenas-Munar, Marina; Cepeda, Violeta; Ugarriza, Lucia; Gomez, Cristina; Mateos, David; Tur, Josep A.] Univ Balearic Isl IUN, Res Grp Community Nutr & Oxidat Stress, Palma De Mallorca 07122, Spain. [Garcia, Silvia; Bouzas, Cristina; Rodenas-Munar, Marina; Cepeda, Violeta; Ugarriza, Lucia; Gomez, Cristina; Mateos, David; Tur, Josep A.] Hlth Res Inst Balearic Isl IdISBa, Palma De Mallorca 07120, Spain. [Garcia, Silvia; Bouzas, Cristina; Rodenas-Munar, Marina; Ugarriza, Lucia; Mateos, David; Tur, Josep A.] Inst Hlth Carlos III, CIBEROBN Physiopathol Obes & Nutr CB12 03 30038, Madrid 28029, Spain. [Ugarriza, Lucia] IBSalut, Primary Hlth Care Ctr Camp Redo, Palma De Mallorca 07010, Spain. [Casares, Miguel] Red Asistencial Juaneda, Radiodiag Serv, Palma De Mallorca 07011, Spain. [Gomez, Cristina] Univ Hosp Son Espases, Clin Anal Serv, Palma De Mallorca 07120, Spain. [Mateos, David] Hosp Manacor, Serv Microbiol, Manacor 07500, Spain. C3 Institut Investigacio Sanitaria Illes Balears (IdISBa); CIBER - Centro de Investigacion Biomedica en Red; CIBEROBN; Hospital Universitari Son Espases; Hospital de Manacor RP Tur, JA (通讯作者)，Univ Balearic Isl IUN, Res Grp Community Nutr & Oxidat Stress, Palma De Mallorca 07122, Spain.; Tur, JA (通讯作者)，Hlth Res Inst Balearic Isl IdISBa, Palma De Mallorca 07120, Spain.; Tur, JA (通讯作者)，Inst Hlth Carlos III, CIBEROBN Physiopathol Obes & Nutr CB12 03 30038, Madrid 28029, Spain. EM pep.tur@uib.es RI ; Tur, Josep/AAE-5748-2020; Bouzas, Cristina/AAE-2069-2019 OI Ródenas Munar, Marina/0009-0009-0954-039X; Tur, Josep/0000-0002-6940-0761; Bouzas Velasco, Cristina/0000-0002-1407-8461; GOMEZ COBO, CRISTINA/0000-0002-9776-4730; García, Silvia/0000-0003-3534-1588 FU Red EXERNET-Red de Ejercicio Fsico y Salud [RED2022-134800-T]; IDISBA Grants (FOLIUM, PRIMUS, SYNERGIA and LIBERI); Agencia Estatal de Investigacin (Ministerio de Ciencias e Innovacin, Spain); Fundaci La Marat TV3 (Spain) [201630.10]; European Regional Development Fund [CIBEROBN CB12/03/30038] FX Funding came from the Instituto de Salud Carlos III through the Fondo de Investigacion para la Salud (CIBEROBN CB12/03/30038), which is cofounded by the European Regional Development Fund; Fundacio La Marato TV3 (Spain), project ref. 201630.10; IDISBA Grants (FOLIUM, PRIMUS, SYNERGIA and LIBERI); and Red EXERNET-Red de Ejercicio Fisico y Salud (RED2022-134800-T) Agencia Estatal de Investigacion (Ministerio de Ciencias e Innovacion, Spain). 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Lopez-Miranda, Jose Delgado-Lista, Javier TI Different Dietary Approaches, Non-Alcoholic Fatty Liver Disease and Cardiovascular Disease: A Literature Review SO NUTRIENTS LA English DT Review DE non-alcoholic fatty liver disease; Mediterranean diet; intermittent fasting; low-fat diet; ketogenic diet; low-carbohydrate diet; DASH diet; cardiovascular disease ID IMPROVES ENDOTHELIAL FUNCTION; MEDITERRANEAN DIET; WEIGHT-LOSS; HEPATIC STEATOSIS; GENETIC-FACTORS; EATING HABITS; DASH DIET; ADHERENCE; RISK; ASSOCIATION AB Non-alcoholic fatty liver disease (NAFLD) is the first cause of chronic liver disease and is also associated with other harmful entities such as obesity, metabolic syndrome, dyslipidemia, and diabetes. NAFLD is a significant public health concern worldwide, impacting individuals of all ages, and its prevalence is projected to increase in the near future due to its connection with obesity. Intrinsic (genetics) and external (lifestyle) factors may also modulate NAFLD, and, in turn, may partly explain the observed relationship between NAFLD and cardiovascular disease (CVD). Although many drugs are been tested to treat NAFLD, to date, no drug has indication to specifically treat this disorder. Thus, the current management of NAFLD relies on lifestyle modifications and specifically on weight loss, physical activity, and the intake of a healthy diet. In the present narrative review, we will discuss the effects of certain dietary patterns on NAFLD incidence and progression. C1 [Torres-Pena, Jose D.; Arenas-de Larriva, Antonio P.; Alcala-Diaz, Juan F.; Lopez-Miranda, Jose; Delgado-Lista, Javier] Univ Cordoba, Reina Sofia Univ Hosp, Maimonides Biomed Res Inst Cordoba IMIBIC, Dept Internal Med,Lipids & Atherosclerosis Unit, Ave Menendez Pidal S-N, Cordoba 14004, Spain. [Torres-Pena, Jose D.; Arenas-de Larriva, Antonio P.; Alcala-Diaz, Juan F.; Lopez-Miranda, Jose; Delgado-Lista, Javier] Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr CIBEROBN, Madrid 28029, Spain. C3 Universidad de Cordoba; Instituto de Salud Carlos III; CIBER - Centro de Investigacion Biomedica en Red; CIBEROBN RP Lopez-Miranda, J; Delgado-Lista, J (通讯作者)，Univ Cordoba, Reina Sofia Univ Hosp, Maimonides Biomed Res Inst Cordoba IMIBIC, Dept Internal Med,Lipids & Atherosclerosis Unit, Ave Menendez Pidal S-N, Cordoba 14004, Spain.; Lopez-Miranda, J; Delgado-Lista, J (通讯作者)，Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr CIBEROBN, Madrid 28029, Spain. 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2016, HEPATOLOGY, V64, P73, DOI 10.1002/hep.28431 Zade MR, 2016, LIVER INT, V36, P563, DOI 10.1111/liv.12990 NR 79 TC 27 Z9 30 U1 1 U2 17 PU MDPI PI BASEL PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND EI 2072-6643 J9 NUTRIENTS JI Nutrients PD MAR PY 2023 VL 15 IS 6 AR 1483 DI 10.3390/nu15061483 PG 17 WC Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Nutrition & Dietetics GA A9GI8 UT WOS:000958126000001 PM 36986213 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Ristic-Medic, D Kovacic, M Takic, M Arsic, A Petrovic, S Paunovic, M Jovicic, M Vucic, V AF Ristic-Medic, Danijela Kovacic, Marijana Takic, Marija Arsic, Aleksandra Petrovic, Snjezana Paunovic, Marija Jovicic, Maja Vucic, Vesna TI Calorie-Restricted Mediterranean and Low-Fat Diets Affect Fatty Acid Status in Individuals with Nonalcoholic Fatty Liver Disease SO NUTRIENTS LA English DT Article DE nonalcoholic fatty liver disease; steatosis; Mediterranean diet; low-fat diet; fatty liver index; HOMA-IR index; fatty acids AB Lifestyle modifications are the main support of nonalcoholic fatty liver disease (NAFLD) therapy. Weight loss is one of the primary goals in NAFLD, but the effects of different calorie-restricted diets remain unclear. Thus, we evaluated the effects of two calorie-restricted diets-the Mediterranean diet (Med diet) and low-fat diet-on liver status, cardiometabolic markers, and fatty acid profiles in patients with NAFLD. Twenty-four overweight/moderately obese men were randomly assigned to consume one of these diets. Lipid levels, glucose, insulin, liver enzymes, steatosis, and fatty acid profiles of serum and erythrocytes phospholipids were assessed. After 3 months, all participants had a significant weight loss (>9%), with improvements in waist circumference, body fat %, index of visceral adiposity (VAI), lipid accumulation product, fatty liver (FLI), and hepatic steatosis (HSI) index (p < 0.001). Both diets significantly lowered triglycerides, total and LDL-cholesterol, liver enzymes, fasting glucose, insulin, and HOMA-IR index. Fatty acid profiles were enhanced after both diets, with a significantly decreased n-6/n-3 ratio. Participants on the Med diet had higher levels of HDL-cholesterol and monounsaturated and n-3 docosahexaenoic acids in serum phospholipids and lower levels of saturated fatty acids, triglycerides, TG/HDL ratio, and FLI when compared to participants on the low-fat diet. Our results indicate that dietary patterns and calorie restriction represent central therapeutic issues in the improvement of obesity-related cardiometabolic alterations that are involved in the mechanism of hepatic steatosis. The Med diet may contribute to disease treatment even more than the low-fat diet since it leads to decreased saturated and increased monounsaturated and n-3 polyunsaturated fatty acid status and improved FLI in NAFLD patients. C1 [Ristic-Medic, Danijela; Arsic, Aleksandra; Petrovic, Snjezana; Paunovic, Marija; Vucic, Vesna] Univ Belgrade, Grp Nutr Biochem & Dietol, Ctr Res Excellence Nutr & Metab, Inst Med Res, Belgrade 11000, Serbia. [Kovacic, Marijana] Univ Belgrade, Inst Med Res, Grp Immunol, Belgrade 11000, Serbia. [Takic, Marija] Univ Belgrade, Ctr Res Excellence Nutr & Metab, Inst Med Res, Grp Nutr & Metab, Belgrade 11000, Serbia. [Jovicic, Maja] Clin Hosp Ctr Dr Dragisa Misovic Dedinje, Dept Gastroenterol, Belgrade 11000, Serbia. [Jovicic, Maja] Euromed Clin, Belgrade 11070, Serbia. C3 University of Belgrade; University of Belgrade; University of Belgrade RP Ristic-Medic, D (通讯作者)，Univ Belgrade, Grp Nutr Biochem & Dietol, Ctr Res Excellence Nutr & Metab, Inst Med Res, Belgrade 11000, Serbia. EM dristicmedic@gmail.com; marijana.buac@imi.bg.ac.rs; marijapo2001@gmail.com; aleksandraarsicimi@gmail.com; snjezana5.imr12@yahoo.com; paunovic.marija90@gmail.com; maja.tufegdzic@gmail.com; vesna.vucic.imr@gmail.com RI Paunovic, Marija/ADR-4681-2022; Ristic-Medic, Danijela/J-6624-2013; Vucic, Vesna/AFN-8591-2022 OI Paunovic, Marija/0000-0001-5148-7523; Ristic-Medic, Danijela/0000-0002-7041-4220; Vucic, Vesna/0000-0002-8563-594X; Takic, Marija/0000-0001-8449-165X; Arsic, Aleksana/0000-0001-8498-9415 FU Ministry of Education, Science and Technological Development of the Republic of Serbia [451-03-68/2020-14/200015] FX This work was supported by the Ministry of Education, Science and Technological Development of the Republic of Serbia (contract 451-03-68/2020-14/200015). 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Diets are one of the most important factors in the development of NAFLD, and in shaping gut microbiome. The role of the gut microbiota in the development of NAFLD has been increasingly studied in recent years. Therefore, the relationship among diet, the gut microbiome, and NAFLD requires discussion and clarification. Scope and approach: This review provides a comprehensive survey of the effects of the Western diet, Mediterranean diet, and Vegetarian diet on NAFLD and summarizes the current known mechanisms by which the gut microbiome affects NAFLD. In addition, the manner by which diet affects NAFLD via alteration of characteristic microorganism was also evaluated. Key Findings and Conclusions: In the Mediterranean diets, the representative foods such as olive oil (rich in MUFA) and fish (rich in omega-3 PUFA) reduce the risk of NAFLD. Typical foods in the Vegetarian diets are vegetables, fruits, nuts, whole grains. These foods are rich in dietary fiber, polyphenol, folate and carotenoid, which are beneficial against the pathogenesis of NAFLD. Red and processed meat (rich in saturated fat) and sugar (rich in fructose) are the most common foods in the Western diet, which may contribute to the development of NAFLD. The gut microbiome exerts various effects on the development and progression of NAFLD, by affecting host energy balance, intestinal permeability, choline metabolism and short-chain fatty acids production. Furthermore, the different diets promoted the growth of characteristic microorganisms associated with NAFLD. Clarifying these associations will be useful for future dietary interventions in patients with NAFLD. C1 [Zhang, Qing-Song; Tian, Feng-Wei; Zhao, Jian-Xin; Zhang, Hao; Zhai, Qi-Xiao; Chen, Wei] Jiangnan Univ, State Key Lab Food Sci & Technol, Wuxi 214122, Jiangsu, Peoples R China. [Zhang, Qing-Song; Tian, Feng-Wei; Zhao, Jian-Xin; Zhang, Hao; Zhai, Qi-Xiao; Chen, Wei] Jiangnan Univ, Sch Food Sci & Technol, Wuxi 214122, Jiangsu, Peoples R China. [Zhang, Hao; Chen, Wei] Jiangnan Univ, Natl Engn Res Ctr Funct Food, Wuxi 214122, Jiangsu, Peoples R China. [Zhang, Hao] Wuxi Branch, Res Inst, Wuxi Translat Med Res Ctr & Jiangsu Translat Med, Wuxi, Jiangsu, Peoples R China. [Zhang, Hao] Jiangnan Univ, Yangzhou Inst Food Biotechnol, Yangzhou 225004, Jiangsu, Peoples R China. [Zhai, Qi-Xiao] Jiangnan Univ, Int Joint Res Lab Probiot, Wuxi 214122, Jiangsu, Peoples R China. [Chen, Wei] BTBU, Beijing Innovat Ctr Food Nutr & Human Hlth, Beijing 100048, Peoples R China. C3 Jiangnan University; Jiangnan University; Jiangnan University; Jiangnan University; Jiangnan University; Beijing Technology & Business University RP Zhai, QX (通讯作者)，Jiangnan Univ, State Key Lab Food Sci & Technol, Wuxi 214122, Jiangsu, Peoples R China. EM zhaiqixiao@sina.com RI Zhai, Qixiao/IWU-8606-2023 FU National Natural Science Foundation of China Program [31820103010, 31530056, 318717731]; Natural Science Foundation of Jiangsu Province [BK20160175]; National First-Class Discipline Program of Food Science and Technology [JUFSTR20180102]; BBSRC Newton Fund Joint Centre Award; Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province FX This work was supported by the National Natural Science Foundation of China Program [No.31820103010, No. 31530056 and No. 318717731; the Natural Science Foundation of Jiangsu Province [BK20160175); National First-Class Discipline Program of Food Science and Technology [JUFSTR20180102]; the BBSRC Newton Fund Joint Centre Award; and Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province. 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Technol. PD FEB PY 2020 VL 96 BP 135 EP 144 DI 10.1016/j.tifs.2019.12.013 PG 10 WC Food Science & Technology WE Science Citation Index Expanded (SCI-EXPANDED) SC Food Science & Technology GA KH9MH UT WOS:000510972200012 DA 2026-02-02 ER PT J AU Fateh, HL Rashid, SA Muhammad, SS Al-Jaf, SH Ali, AM AF Fateh, Hawal Lateef Rashid, Sameeah Abdulrahman Muhammad, Sarmad S. Al-Jaf, Sabah H. Ali, Ayad M. TI Comparing effects of beetroot juice and Mediterranean diet on liver enzymes and sonographic appearance in patients with non-alcoholic fatty liver disease: a randomized control trials SO FRONTIERS IN NUTRITION LA English DT Article DE mediterranean diet; beetroot juice; nonalcoholic fatty liver; RCT; NAFLD ID HEPATIC STEATOSIS; MANAGEMENT; OBESITY; NITRATE AB Background: In both developed and developing countries, non-alcoholic fatty liver disease (NAFLD) has lately risen to the top of the list of chronic liver illnesses. Although there is no permanent cure, early management, diagnosis, and treatment might lessen its effects. The purpose of conducting the current study is to compare the effects of beetroot juice and the Mediterranean diet on the lipid profile, level of liver enzymes, and liver sonography in patients with NAFLD. Methods: In this randomized controlled trial, 180 people with a mean age of (45.19 +/- 14.94) years participated. Participants ranged in age from 19 to 73. The mean weight before intervention was (82.46 +/- 5.97) kg, while the mean weight after intervention was roughly (77.88 +/- 6.26) kg. The trial lasted for 12 weeks. The participants were split into four groups: control, a Mediterranean diet with beet juice (BJ + MeD), Mediterranean diet alone (MeD), and beetroot juice (BJ). The Mediterranean diet included fruits, vegetables, fish, poultry, and other lean meats (without skin), sources of omega-3 fatty acids, nuts, and legumes. Beetroot juice had 250 mg of beetroot. Data analysis was done using SPSS software (version 26.0). p < 0.05 is the statistical significance level. Results: Following the intervention, Serum Bilirubin, alkaline phosphatase (ALP), alanine transaminase (ALT), serum cholesterol (CHOL), triglyceride (TG), and lowdensity lipoprotein (LDL) levels were significantly decreased in the BJ + MeD, BJ, and MeD groups (p = 0.001). Also, high-density lipoprotein (HDL) significantly increased in the BJ + MeD, BJ, and MeD groups (p = 0.001), while decreasing in the Control group (p = 0.001). Conclusion: The research findings indicate a significant reduction in hepatic steatosis among the groups receiving beetroot juice (BJ) and beetroot juice combined with the Mediterranean diet (BJ + MeD). This suggests that beetroot juice holds potential as an effective treatment for non-alcoholic fatty liver disease (NAFLD) in adults. Furthermore, the combination of beetroot juice with the Mediterranean diet showed enhanced efficacy in addressing NAFLD. C1 [Fateh, Hawal Lateef] Sulaimani Polytech Univ, Kalar Tech Coll, Nursing Dept, Sulaymaniyah, Iraq. [Fateh, Hawal Lateef] Garmian Polytech Univ, Kalar Tech Coll, Nursing Dept, Kalar, Iraq. [Rashid, Sameeah Abdulrahman] Hawler Med Univ, Coll Med, Dept Surg, Erbil, Iraq. [Muhammad, Sarmad S.] Sulaimani Polytech Univ, Kalar Tech Coll, Med Lab Technol Dept, Sulaymaniyah, Iraq. [Muhammad, Sarmad S.] Garmian Polytech Univ, Kalar Tech Coll, Med Lab Technol Dept, Kalar, Iraq. [Al-Jaf, Sabah H.; Ali, Ayad M.] Univ Garmian, Coll Sci, Dept Chem, Sulaimani, Iraq. C3 Sulaimani Polytechnic University; Hawler Medical University; Sulaimani Polytechnic University; University of Garmian RP Fateh, HL (通讯作者)，Sulaimani Polytech Univ, Kalar Tech Coll, Nursing Dept, Sulaymaniyah, Iraq.; Fateh, HL (通讯作者)，Garmian Polytech Univ, Kalar Tech Coll, Nursing Dept, Kalar, Iraq. EM hawallatif@gmail.com RI Lateef Fateh, Hawal/AED-8077-2022 FU This research was supported by Garmian Polytechnic University.; Garmian Polytechnic University FX We would like to thank each participant and deputy of Garmian Polytechnic University.r This research was supported by Garmian Polytechnic University. 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PD AUG 17 PY 2023 VL 10 AR 1181706 DI 10.3389/fnut.2023.1181706 PG 11 WC Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Nutrition & Dietetics GA Q6XT1 UT WOS:001058941100001 PM 37662597 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Diaconu, CT Guja, C AF Diaconu, Cosmina-Theodora Guja, Cristian TI Nonalcoholic Fatty Liver Disease and Its Complex Relation with Type 2 Diabetes Mellitus-From Prevalence to Diagnostic Approach and Treatment Strategies SO JOURNAL OF CLINICAL MEDICINE LA English DT Review DE Nonalcoholic Fatty Liver Disease (NAFLD); Type 2 Diabetes Mellitus (T2DM); Metabolic Syndrome-Associated Fatty Liver Disease (MAFLD); treatment ID HEPATIC INSULIN-RESISTANCE; MEDITERRANEAN DIET; PHYSICAL-ACTIVITY; SCORING SYSTEM; ADIPOSE-TISSUE; STEATOSIS; FIBROSIS; OBESITY; ASSOCIATION; EXERCISE AB Prevalence of Nonalcoholic Fatty Liver Disease (NAFLD) and Type 2 Diabetes Mellitus (T2DM) are increasing rapidly worldwide, reaching epidemic proportions. Their association, based on common metabolic risk factors (obesity, insulin resistance (IR), unhealthy lifestyle), brings an additional risk of both hepatic and cardiovascular (CV) adverse clinical outcomes. The terminology of "NAFLD" is stigmatizing to some but not all patients, and a more practical one should be announced soon. Medical strategies can address both diseases simultaneously, as they have crossing pathophysiological mechanisms, mainly IR. Strategies vary from lifestyle intervention and pharmacological options, as more molecules designated for T2DM treatment may be helpful in NAFLD, to surgical procedures. This review focuses on the coexistence of NAFLD and T2DM, pointing out the utility of the appropriate terminology, its prevalence, and mortality rates among the diabetic population. Briefly, we have discussed the main pathophysiological mechanisms and the risk stratification algorithm for the development of NAFLD and nonalcoholic steatohepatitis (NASH) as well as the tools for evaluation of fibrosis. Finally, we have focused on the current therapeutic options for the treatment of NAFLD associated with T2DM. C1 [Diaconu, Cosmina-Theodora; Guja, Cristian] Prof Dr NC Paulescu Natl Inst Diabet Nutr & Metab, Dept Diabet Nutr & Metab Dis, Bucharest 030167, Romania. [Diaconu, Cosmina-Theodora] Carol Davila Univ Med & Pharm, Doctoral Sch, Dionisie Lupu 37, Bucharest 020021, Romania. [Guja, Cristian] Carol Davila Univ Med & Pharm, Dept Diabet Nutr & Metab Dis, Bucharest 020021, Romania. 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Clin. Med. PD SEP PY 2022 VL 11 IS 17 AR 5144 DI 10.3390/jcm11175144 PG 15 WC Medicine, General & Internal WE Science Citation Index Expanded (SCI-EXPANDED) SC General & Internal Medicine GA 4J2DD UT WOS:000851078400001 PM 36079070 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Xie, XF Guo, B Xiao, X Yin, JZ Wang, ZY Jiang, XM Li, JZ Long, L Zhou, JM Zhang, N Zhang, Y Chen, T Kangzhuo, B Zhao, X AF Xie, Xiaofen Guo, Bing Xiao, Xiong Yin, Jianzhong Wang, Ziyun Jiang, Xiaoman Li, Jingzhong Long, Lu Zhou, Junmin Zhang, Ning Zhang, Yuan Chen, Ting Kangzhuo, Baima Zhao, Xing TI Healthy dietary patterns and metabolic dysfunction-associated fatty liver disease in less-developed ethnic minority regions: a large cross-sectional study SO BMC PUBLIC HEALTH LA English DT Article DE MAFLD; Metabolic; NAFLD; Dietary pattern; Obesity ID POSITION STATEMENT; MEDITERRANEAN DIET; NONOBESE PATIENTS; DASH DIET; RISK; REDEFINITION; PREVALENCE; ADHERENCE; ADULTS AB Background Little is known about the associations between healthy dietary patterns and metabolic dysfunction-associated fatty liver disease (MAFLD) in less-developed ethnic minority regions (LEMRs), where the prevalence of MAFLD is increasing rapidly and dietary habits are quite different from those in developed countries. Moreover, a significant subset of MAFLD individuals in LEMRs are nonobese, but the efficacy of dietary patterns on MAFLD individuals with different obese statuses is also unclear. We aimed to test the associations of two wildly recommended a priori dietary patterns-Alternate Mediterranean diet (AMED) and Dietary Approaches to Stop Hypertension (DASH)-with the risk of MAFLD in the total population, and further in nonobese and obese individuals. Methods We recruited 99,556 participants in the China Multi-Ethnic Cohort Study, an ongoing cohort study in less-developed southwest China. Using validated food frequency questionnaire, each participant was assigned an AMED score and a DASH score. MAFLD was ascertained as hepatic steatosis on ultrasound together with diabetes, overweight/obesity, or two other metabolic risk factors. We performed logistic regression with inverse probability of exposure weighting (IPEW) to examine associations between two dietary patterns and MAFLD, adjusting for potential confounders under the guidance of directed acyclic graphs. Further, analyses were stratified by body mass index. Results We included 66,526 participants (age 49.5 +/- 11.0; 62.6% women), and the prevalence of MAFLD was 16.1%. Participants in the highest quintile of DASH score showed strong inverse associations with risks of MAFLD (OR = 0.85; 95% CI, 0.80-0.91; P-trend < 0.001) compared with participants in the lowest quintile. The association between DASH and nonobese MAFLD (OR = 0.69; 95% CI, 0.61-0.78; P-trend < 0.001) was stronger (I-2 = 78.5 % ; P-heterogeneity = 0.001) than that with obese MAFLD (OR = 0.90; 95% CI, 0.83-0.98; P-trend = 0.002). There was a null association between AMED and MAFLD risk. Conclusions In LEMRs, a DASH diet but not AMED was associated with MAFLD. The relationship appeared to be more pronounced in nonobese MAFLD individuals than in obese MAFLD individuals. C1 [Xie, Xiaofen; Guo, Bing; Xiao, Xiong; Long, Lu; Zhou, Junmin; Zhang, Ning; Zhang, Yuan; Zhao, Xing] Sichuan Univ, West China Sch Publ Hlth, 16 Peoples South Rd, Chengdu 610041, Peoples R China. [Xie, Xiaofen; Guo, Bing; Xiao, Xiong; Long, Lu; Zhou, Junmin; Zhang, Ning; Zhang, Yuan; Zhao, Xing] Sichuan Univ, West China Hosp 4, 16 Peoples South Rd, Chengdu 610041, Peoples R China. [Yin, Jianzhong] Kunming Med Univ, Sch Publ Hlth, Kunming, Yunnan, Peoples R China. [Yin, Jianzhong] Baoshan Coll Tradit Chinese Med, Kunming, Yunnan, Peoples R China. [Wang, Ziyun] Guizhou Med Univ, Sch Publ Hlth, Key Lab Environm Pollut Monitoring & Dis Control, Minist Educ, Guiyang, Peoples R China. [Jiang, Xiaoman] Chengdu Ctr Dis Control & Prevent, Chengdu, Peoples R China. [Li, Jingzhong] Tibet Ctr Dis Control & Prevent, Lhasa, Peoples R China. [Chen, Ting] Chongqing Municipal Ctr Dis Control & Prevent, 8 Changjiang 2nd Rd, Chongqin 400042, Peoples R China. [Kangzhuo, Baima] Tibet Univ, 10 East Tibet Univ Rd, Lhasa 850000, Peoples R China. C3 Sichuan University; Sichuan University; Kunming Medical University; Guizhou Medical University; Xizang University RP Zhao, X (通讯作者)，Sichuan Univ, West China Sch Publ Hlth, 16 Peoples South Rd, Chengdu 610041, Peoples R China.; Chen, T (通讯作者)，Chongqing Municipal Ctr Dis Control & Prevent, 8 Changjiang 2nd Rd, Chongqin 400042, Peoples R China.; Kangzhuo, B (通讯作者)，Tibet Univ, 10 East Tibet Univ Rd, Lhasa 850000, Peoples R China. EM 640963985@qq.com; bmkz123@163.com; xingzhao@scu.edu.cn RI Zhou, Junmin/S-5639-2016; Zhao, Xing/GLS-7344-2022; Xiao, Xiong/KOD-4332-2024; Wang, Ziyun/I-4412-2012 FU National Key Research and Development Program of China [2017YFC0907303]; National Natural Science Foundation of China [81773548, 81973151]; Key R&D Project of Sichuan Province Science and Technology Support Program [2020YFS0215]; CNS-ZD Tizhi and Health Fund [CNS-ZD2020-149] FX The CMEC study was funded by the National Key Research and Development Program of China (Grant No. 2017YFC0907303). Xiong Xiao was supported by the National Natural Science Foundation of China (Grant No. 81903415), the Key R&D Project of Sichuan Province Science and Technology Support Program (Grant No. 2020YFS0215) and CNS-ZD Tizhi and Health Fund (Grant No. CNS-ZD2020-149). Xing Zhao was supported by the National Natural Science Foundation of China (Grant No. 81773548, and 81973151). The views expressed are those of the author(s) and not necessarily those of the funders. The funders had no role in the design of the study and collection, analysis, and interpretation of data and in writing the manuscript. 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gold DA 2026-02-02 ER PT J AU Eslamparast, T Tandon, P Raman, M AF Eslamparast, Tannaz Tandon, Puneeta Raman, Maitreyi TI Dietary Composition Independent of Weight Loss in the Management of Non-Alcoholic Fatty Liver Disease SO NUTRIENTS LA English DT Review DE non-alcoholic fatty liver disease; dietary composition; Mediterranean diet ID STOP HYPERTENSION DASH; INSULIN-RESISTANCE; MEDITERRANEAN DIET; HEPATIC STEATOSIS; OXIDATIVE STRESS; LIPID-METABOLISM; BLOOD-PRESSURE; STEATOHEPATITIS; PATHOGENESIS; ACID AB Poor dietary composition is an important factor in the progression of non-alcoholic fatty liver disease (NAFLD). The majority of NAFLD patients follow diets with overconsumption of simple carbohydrates, total and saturated fat, with reduced intake of dietary fiber and omega-3 rich foods. Although lifestyle modifications including weight loss and exercise remain the keystone of NAFLD management, modifying dietary composition with or without a calorie-restricted diet may also be a feasible and sustainable strategy for NAFLD treatment. In the present review article, we highlight the potential therapeutic role of a "high quality healthy diet" to improve hepatic steatosis and metabolic dysfunction in patients with NAFLD, independent of caloric restriction and weight loss. We provide a literature review evaluating the evidence behind dietary components including fiber-, meat-and omega-3-rich diets and, pending further evidence, we concur with the EASL-EASD-EASO Clinical Guidelines recommendation of the Mediterranean diet as the diet of choice in these patients. C1 [Eslamparast, Tannaz; Tandon, Puneeta] Univ Alberta, Div Gastroenterol, Dept Med, Edmonton, AB T6G 2X8, Canada. [Tandon, Puneeta] Univ Alberta, Cirrhosis Care Clin, Edmonton, AB T6G 2X8, Canada. [Tandon, Puneeta] Univ Alberta, CEGIIR, Edmonton, AB T6G 2X8, Canada. [Raman, Maitreyi] Univ Calgary, Div Gastroenterol, Dept Med, Calgary, AB T6G 2X8, Canada. C3 University of Alberta; University of Alberta; University of Alberta; University of Calgary RP Raman, M (通讯作者)，Univ Calgary, Div Gastroenterol, Dept Med, Calgary, AB T6G 2X8, Canada. 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Nonalcoholic fatty liver disease; Adults ID METABOLIC SYNDROME; GUT MICROBIOTA; WEIGHT-LOSS; CARDIOVASCULAR-DISEASE; LIFE-STYLE; VITAMIN-E; INTESTINAL MICROBIOTA; INSULIN-RESISTANCE; ADHERENCE; HEALTH AB Nonalcoholic fatty liver disease (NAFLD) is emerging as the most common chronic liver disease, and is characterized by a wide spectrum of fat-liver disorders that can result in severe liver disease and cirrhosis. Inflammation and oxidative stress are the major risk factors involved in the pathogenesis of NAFLD. Currently, there is no consensus concerning the pharmacological treatment of NAFLD. However, lifestyle interventions based on exercise and a balanced diet for quality and quantity, are considered the cornerstone of NAFLD management. Mediterranean diet (MD), rich in polyunsaturated fats, polyphenols, vitamins and carotenoids, with their anti-inflammatory and antioxidant effects, has been suggested to be effective in preventing cardiovascular risk factors. In adults, MD has also been demonstrated to be efficacious in reducing the risk of metabolic syndrome. However, few studies are available on the effects of the MD in both adult and pediatric subjects with NAFLD. Thus, the aims of the present narrative review are to analyze the current clinical evidence on the impact of MD in patients with NAFLD, and to summarize the main mechanisms of action of MD components on this condition. C1 [Anania, Caterina; Perla, Francesco Massimo; Olivero, Francesca; Pacifico, Lucia] Sapienza Univ Rome, Policlin Umberto Hosp 1, I-00161 Rome, Italy. [Chiesa, Claudio] CNR, Inst Translat Pharmacol, Via Fosso del Cavaliere 100, I-00133 Rome, Italy. C3 Sapienza University Rome; University Hospital Sapienza Rome; Consiglio Nazionale delle Ricerche (CNR); Istituto di Farmacologia Traslazionale (IFT-CNR) RP Chiesa, C (通讯作者)，CNR, Inst Translat Pharmacol, Via Fosso del Cavaliere 100, I-00133 Rome, Italy. 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It is also an independent risk factor for non-communicable diseases. In 2020, a proposal was made to refer to it as "metabolic dysfunction-associated fatty liver disease (MAFLD)", with concise diagnostic criteria. Given its widespread occurrence, its treatment is crucial. Increased levels of oxidative stress cause this disease. This review aims to evaluate various studies on antioxidant therapies for patients with MAFLD. A comprehensive search for relevant research was conducted on the PubMed, SCOPUS, and ScienceDirect databases, resulting in the identification of 87 studies that met the inclusion criteria. In total, 31.1% of human studies used natural antioxidants, 53.3% used synthetic antioxidants, and 15.5% used both natural and synthetic antioxidants. In human-based studies, natural antioxidants showed 100% efficacy in the treatment of MAFLD, while synthetic antioxidants showed effective results in only 91% of the investigations. In animal-based research, natural antioxidants were fully effective in the treatment of MAFLD, while synthetic antioxidants demonstrated effectiveness in only 87.8% of the evaluations. In conclusion, antioxidants in their natural form are more helpful for patients with MAFLD, and preserving the correct balance of pro-oxidants and antioxidants is a useful way to monitor antioxidant treatment. C1 [Mohammadian, Kiana; Fakhar, Fatemeh] Shiraz Univ Med Sci, Sch Paramed Sci, Dept Med Lab Sci, Div Hematol & Blood Banking, Shiraz 71348, Iran. [Keramat, Shayan; Stanek, Agata] VAS European Independent Fdn Angiol Vasc Med, Via GB Grassi 74, I-20157 Milan, Italy. [Keramat, Shayan] Buergers Dis NGO, Support Assoc Patients Buergers Dis, Mashhad 9183785195, Iran. [Stanek, Agata] Med Univ Silesia, Fac Med Sci Zabrze, Dept & Clin Internal Med Angiol & Phys Med, PL-41902 Bytom, Poland. 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Molecular Biology; Chemistry, Medicinal; Food Science & Technology WE Science Citation Index Expanded (SCI-EXPANDED) SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science & Technology GA ZP8H4 UT WOS:001276586300001 PM 39061866 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Barrera, F George, J AF Barrera, Francisco George, Jacob TI The Role of Diet and Nutritional Intervention for the Management of Patients with NAFLD SO CLINICS IN LIVER DISEASE LA English DT Article DE Nonalcoholic fatty liver; Macronutrients; Lifestyle intervention; Steatohepatitis; Mediterranean diet; Weight loss; Insulin resistance ID FATTY LIVER-DISEASE; WEIGHT-LOSS MAINTENANCE; LOW-CARBOHYDRATE DIETS; SERUM ALANINE AMINOTRANSFERASE; CORONARY-HEART-DISEASE; NONALCOHOLIC STEATOHEPATITIS; CARDIOVASCULAR-DISEASE; VITAMIN-E; INSULIN SENSITIVITY; MEDITERRANEAN DIET AB During the last few decades, the prevalence of obesity, insulin resistance and non-alcoholic fatty liver disease (NAFLD) have dramatically increased. Nutrition and modern lifestyle habits are intimately involved in this epidemiological change. Although lifestyle intervention can theoretically revert the metabolic disturbances and prevent the long-term complications of NAFLD, its efficacy is diminished in clinical practice by poor implementation and reduced adherence to lifestyle intervention programs. In this article we summarize the main elements of dietary interventions for NAFLD, describe practical strategies to optimize efficacy and review potential nutritional strategies under development that hopefully will improve outcomes in the future. C1 [Barrera, Francisco; George, Jacob] Univ Sydney, Westmead Hosp, Westmead Millennium Inst, Storr Liver Unit, Westmead, NSW 2145, Australia. [Barrera, Francisco] Pontificia Univ Catolica Chile, Dept Gastroenterol, Santiago 8330024, Chile. C3 University of Sydney; Westmead Institute for Medical Research; NSW Health; Westmead Hospital; Pontificia Universidad Catolica de Chile RP George, J (通讯作者)，Westmead Hosp, Dept Med, Storr Liver Unit, Darcy Rd, Westmead, NSW 2145, Australia. EM jacob.george@sydney.edu.au RI ; George, Jacob/P-1496-2014 OI Barrera, Francisco/0000-0001-5334-1528; George, Jacob/0000-0002-8421-5476 FU Sydney Medical Foundation; University of Sydney; National Health and Medical Research Council [NHMRC 632630, 1049857] FX Robert W. Starr Bequest to The Sydney Medical Foundation, University of Sydney, and National Health and Medical Research Council (NHMRC 632630 and 1049857). 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10.3945/jn.111.155325 NR 97 TC 93 Z9 117 U1 0 U2 40 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 1089-3261 EI 1557-8224 J9 CLIN LIVER DIS JI Clin. Liver Dis. PD FEB PY 2014 VL 18 IS 1 BP 91 EP + DI 10.1016/j.cld.2013.09.009 PG 24 WC Gastroenterology & Hepatology WE Science Citation Index Expanded (SCI-EXPANDED) SC Gastroenterology & Hepatology GA 278VL UT WOS:000328917900008 PM 24274867 DA 2026-02-02 ER PT J AU De Matteis, C Novielli, F Di Buduo, E Arconzo, M Gadaleta, RM Cariello, M Moschetta, A Crudele, L AF De Matteis, Carlo Novielli, Fabio Di Buduo, Ersilia Arconzo, Maria Gadaleta, Raffaella Maria Cariello, Marica Moschetta, Antonio Crudele, Lucilla TI Atherogenic index of plasma identifies subjects with severe liver steatosis SO SCIENTIFIC REPORTS LA English DT Article DE Metabolic syndrome; MASLD; Atherosclerosis; Obesity; Diabetes; Mediterranean diet ID INSULIN-RESISTANCE; CONSENSUS STATEMENT; GENE-EXPRESSION; DISEASE; CHOLESTEROL; LXR; ATHEROSCLEROSIS; ACTIVATION; SREBP-1C AB The Atherogenic Index of Plasma (AIP), calculated by log (Triglycerides/HDL-C), has been proposed as a marker of atherogenic and cardiovascular risk. Atherosclerosis and Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) share some pathogenic features and may be considered clinical manifestations of Metabolic Syndrome. In this study, we aimed to investigate the role of increased AIP as a putative metabolic biomarker for MASLD. 1,496 individuals (49% males and 51% females) underwent clinical examination for Metabolic Syndrome at Internal Medicine Division "C. Frugoni" of University Hospital of Bari, Italy in the period between January 2016 and April 2024. Clinical history was recorded, and physical examination, anthropometric measures, biochemical assessment, and abdomen ultrasound were performed. In the overall population, AIP significantly correlated with fasting glycemia (FPG, r = 0.26, p < 0.0001), HbA1c (r = 0.20, p < 0.0001), LDL (r = 0.11, p < 0.0001) and total cholesterol (r = 0.09; p < 0.0001), and anthropometric measures of obesity BMI (r = 0.37, p < 0.0001) and Waist Circumference (r = 0.44; p < 0.001). We then investigated AIP values in patients with and without dysmetabolic conditions, finding that AIP significantly increased as steatosis worsened (p < 0.001). ROC curves identified an optimal cut-off of 0.31 for accurately diagnosing severe steatosis and AIP values above this cut-off discriminated patients with significantly increased (p < 0.0001) fasting glycemia, LDL, and waist circumference, and were strongly associated (p < 0.0001) with MASLD (LLR 85.3), type 2 diabetes (LLR 85.5), abdominal obesity (LLR 72.9), overweight (LLR 151.8), and systemic obesity (LLR 178.4). The risk for being diagnosed with such conditions was found to be even higher in the subpopulation of patients with severe liver steatosis. To validate our findings, we considered another cohort of patients with and without biopsy-proven liver steatosis (public dataset GSE89632), confirming that a significant increase (p < 0.001) in AIP values could be found in patients with liver steatosis compared to healthy controls. AIP can be considered a specific biomarker of fatty liver disease with high sensitivity for the diagnosis of the severe form of liver steatosis. Considering AIP in the evaluation of patients with liver steatosis may augment the accuracy for diagnosing metabolic impairment and MASLD. C1 [De Matteis, Carlo; Novielli, Fabio; Di Buduo, Ersilia; Arconzo, Maria; Gadaleta, Raffaella Maria; Cariello, Marica; Moschetta, Antonio; Crudele, Lucilla] Univ Bari Aldo Moro, Dept Interdisciplinary Med, Piazza Giulio Cesare N 11, I-70124 Bari, Italy. [Gadaleta, Raffaella Maria; Cariello, Marica; Moschetta, Antonio; Crudele, Lucilla] INBB Natl Inst Biostruct & Biosyst, Via Dei Carpegna 19, I-00165 Rome, Italy. C3 Universita degli Studi di Bari Aldo Moro RP Moschetta, A; Crudele, L (通讯作者)，Univ Bari Aldo Moro, Dept Interdisciplinary Med, Piazza Giulio Cesare N 11, I-70124 Bari, Italy.; Moschetta, A; Crudele, L (通讯作者)，INBB Natl Inst Biostruct & Biosyst, Via Dei Carpegna 19, I-00165 Rome, Italy. EM antonio.moschetta@uniba.it; lucilla.crudele@uniba.it RI Arconzo, Maria/LSJ-0955-2024; Crudele, Lucilla/AAO-8817-2021; Cariello, Marica/K-4064-2018; De Matteis, Carlo/LSJ-0110-2024 OI Crudele, Lucilla/0000-0002-0541-6211; De Matteis, Carlo/0000-0001-6628-2184 FU PON "RICERCA E INNOVAZIONE" 2014-2020-Innovazione [1062]; MIUR-PRIN Progetti di Ricerca di Rilevante Interesse Nazionale 2022 [2022H9MPZ5]; AIRC [23239]; Italian Ministry of University and Research by the European Union - NextGenerationEU [3138, 341]; Project title "National Center for Gene Therapy and Drugs based on RNA Technology" [CN00000041, CUP H93C22000430007]; Italian Ministry of University and Research [PE00000003, CUP D93C22000890001, PE0000015, 1243, CUP H33C22000680006]; European Union [PNRR-MR1-2022-12376395]; National Recovery and Resilience Plan (NRRP), Mission 4 Component 2 Investment 1.3; [CUP H93C22000780006] FX R.M.G. is funded by PON "RICERCA E INNOVAZIONE" 2014-2020-Innovazione (D.M. 10 AGOSTO 2021, N. 1062). A.M. is funded by MIUR-PRIN Progetti di Ricerca di Rilevante Interesse Nazionale 2022. "Metabolic hits in the road to colon cancer". Codice progetto n. 2022H9MPZ5; AIRC IG 2019 "Regulation of lipid metabol- ic pathways in the gut liver axis: relevance in hepatocarcinoma" Id. 23239; Project funded under the National Recovery and Resilience Plan (NRRP), Mission 4, Component 2 Investment 1.4-Call for tender No. 3138 of 16/12/2021 of Italian Ministry of University and Research funded by the European Union - NextGenerationEU; Project code: CN00000041, CUP H93C22000430007, Project title "National Center for Gene Therapy and Drugs based on RNA Technology". Project funded under the National Recovery and Resilience Plan (NRRP), Mission 4, Component 2 Investment 1.3-Call for tender No. 341 of 15 March 2022 of Italian Ministry of University and Research funded by the European Union - NextGenerationEU; Project code PE00000003, Concession Decree No. 1550 of 11 October 2022 adopted by the Italian Ministry of University and Research, CUP D93C22000890001, Project title "ON Foods-Research and innovation network on food and nutrition Sustain- ability, Safety and Security - Working ON Foods". Project funded by the European Union - Next Generation EU - PNRR M6C2-Investimento 2.1 Valorizzazione e potenziamento della ricerca biomedica del SSN"Project code PNRR-MR1-2022-12376395. CUP H93C22000780006. Project title: Italian Autoimmune Liver Disease (IT-AILD) Clinical Research Network (CRN). L.C. is funded under the National Recovery and Resilience Plan (NRRP), Mission 4 Component 2 Investment 1.3-Call for tender No. 341 of 15 March 2022 of Italian Ministry of University and Research funded by the European Union - NextGeneration EU; Award Number: Project code PE0000015, Concession Decree No. 1243 of 2 August 2022 adopted by the Italian Ministry of University and Research, CUP H33C22000680006, Project title "Ageing well in an ageing society-A novel public-private alliance to generate socioeconomic, biomedical and technological solutions for an inclusive Italian ageing society- AGE- IT". Funders had no role in study design, collection, analysis, and interpretation of data, in the writing of the report, and in the decision to submit the paper for publication. 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The specific role of the dietary factors in the development and progress of the disease are not well illuminated. Thus, we conducted this study on the associations between dietary quality assessed by five dietary quality indexes (Dietary Inflammatory Index, DII; Mediterranean diet, MED; Dietary Approach to Stop Hypertension, DASH; Alternate Healthy Eating Index diet, AHEI; Healthy Eating Indices, HEI) and MAFLD phenotypes. This study was extracted from the latest NHANES 2017-2018 wave. Demographic information, health status, lifestyles, and dietary habits were reported in the questionnaire. Multivariate logistic regression and multivariate ordinal logistic regression methods were applied to explore the associations between dietary quality indexes and MAFLD or MAFLD with liver fibrosis. The weighted prevalence of Non-MAFLD, MAFLD without fibrosis, and MAFLD with fibrosis were 47.05%, 36.67%, and 16.28%, respectively, at the cutoff value of a median Controlled Attenuation Parameter (CAP) 248 dB/m and a median Liver Stiffness Measurement (LSM) 6.3 kPa. When the diagnostic cutoff values of CAP changed to 285 dB/m, the weighted prevalence of Non-MAFLD, MAFLD without liver fibrosis, and MAFLD with fibrosis turned to 64.62%, 22.08%, and 13.30%, respectively. All five dietary quality indexes, including DII, HEI-2015, AHEI, DASH, and MED, were all significantly associated with MAFLD phenotypes. DII was positively associated with MAFLD phenotypes, while other four dietary quality indexes, including HEI-2015, AHEI, DASH, and MED, were significantly associated with lower risk of MAFLD phenotypes. MAFLD is becoming a threatening public health concern among adult Americans and dietary quality is markedly associated with MAFLD phenotypes. C1 [Tian, Ting; Zhang, Jingxian; Xie, Wei; Ni, Yunlong; Fang, Xinyu; Dai, Yue; Zhou, Yonglin] Jiangsu Prov Ctr Dis Control & Prevent, Inst Food Safety & Assessment, Nanjing 210009, Peoples R China. [Liu, Mao] Jiangsu Prov Ctr Dis Control & Prevent, Dept Environm & Hlth, Nanjing 210009, Peoples R China. [Peng, Xianzhen] Nanjing Med Univ, Kangda Coll, Dept Publ Hlth & Prevent Med, Lianyungang 222000, Peoples R China. [Wang, Jie] Nanjing Med Univ, Dept Fundamental & Community Nursing, Sch Nursing, Nanjing 211166, Peoples R China. C3 Jiangsu Provincial Center for Disease Control & Prevention; Jiangsu Provincial Center for Disease Control & Prevention; Nanjing Medical University; Nanjing Medical University RP Dai, Y (通讯作者)，Jiangsu Prov Ctr Dis Control & Prevent, Inst Food Safety & Assessment, Nanjing 210009, Peoples R China. EM 18915999341@163.com RI Tian, Ting/AAE-1437-2022 OI Tian, Ting/0000-0001-5043-0015 FU Jiangsu Provincial Geriatric Health Scientific Research Project [LKM2022005]; Social Science Research Projects in Universities of Jiangsu Province [2020SJA2439]; Six Talent Peaks Project in Jiangsu Province, China [2019-WSN-049] FX This research was funded by Jiangsu Provincial Geriatric Health Scientific Research Project (Grant No. LKM2022005), Social Science Research Projects in Universities of Jiangsu Province (Grant No. 2020SJA2439), and the Six Talent Peaks Project in Jiangsu Province, China (Grant No. 2019-WSN-049). 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Drugs for the treatment of type 2 diabetes mellitus (T2DM), such as metformin, glucagon-like peptide-1 (GLP-1) agonists, and sodium-glucose cotransporter (SGLT) inhibitors, are not only effective in the regulation of glucose homeostasis, but also in the reduction of liver fat content and inflammation, and they are associated with a shift in the gut microbiota composition towards a healthy phenotype. Even bariatric surgery significantly changes the gut microbiota, mostly due to the modification of the gastrointestinal anatomy, with a parallel improvement in histological features of NAFLD. Other options with promising effects in reprogramming the gut-liver axis, such as fecal microbial transplantation (FMT) and next-generation probiotics deserve further investigation for future inclusion in the therapeutic armamentarium of NAFLD. C1 [Maestri, Marta; Santopaolo, Francesco; Pompili, Maurizio; Gasbarrini, Antonio; Ponziani, Francesca Romana] Fdn Policlin Univ Agostino Gemelli IRCCS, Internal Med & Gastroenterol Hepatol Unit, Rome, Italy. [Pompili, Maurizio; Gasbarrini, Antonio; Ponziani, Francesca Romana] Univ Cattolica Sacro Cuore, Dept Translat Med & Surg, Rome, Italy. C3 Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli; Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli RP Ponziani, FR (通讯作者)，Fdn Policlin Univ Agostino Gemelli IRCCS, Internal Med & Gastroenterol Hepatol Unit, Rome, Italy.; Ponziani, FR (通讯作者)，Univ Cattolica Sacro Cuore, Dept Translat Med & Surg, Rome, Italy. 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Nutr. PD FEB 16 PY 2023 VL 10 AR 1110536 DI 10.3389/fnut.2023.1110536 PG 13 WC Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Nutrition & Dietetics GA 9L6DG UT WOS:000941638000001 PM 36875849 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Semmler, G Datz, C Trauner, M AF Semmler, Georg Datz, Christian Trauner, Michael TI Eating, diet, and nutrition for the treatment of non-alcoholic fatty liver disease SO CLINICAL AND MOLECULAR HEPATOLOGY LA English DT Review DE NAFLD; Mediterranean diet; Intermittent fasting; Calorie restricted diet; Precision medicine ID LIFE-STYLE MODIFICATION; DE-NOVO LIPOGENESIS; RANDOMIZED CONTROLLED-TRIAL; RED MEAT CONSUMPTION; MEDITERRANEAN DIET; WEIGHT-LOSS; CARDIOVASCULAR-DISEASE; INSULIN-RESISTANCE; HEPATIC STEATOSIS; GENETIC-VARIATION AB Nutrition and dietary interventions are a central component in the pathophysiology, but also a cornerstone in the management of patients with non-alcoholic fatty liver disease (NAFLD). Summarizing our rapidly advancing understanding of how our diet influences our metabolism and focusing on specific effects on the liver, we provide a comprehensive overview of dietary concepts to counteract the increasing burden of NAFLD. Specifically, we emphasize the importance of dietary calorie restriction independently of the macronutrient composition together with adherence to a Mediterranean diet low in added fructose and processed meat that seems to exert favorable effects beyond calorie restriction. Also, we discuss intermittent fasting as a type of diet specifically tailored to decrease liver fat content and increase ketogenesis, awaiting future study results in NAFLD. Finally, personalized dietary recommendations could be powerful tools to increase the effectiveness of dietary interventions in patients with NAFLD considering the genetic background and the microbiome, among others. 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Mol. Hepatol. PD FEB PY 2023 VL 29 SU S BP S244 EP S260 DI 10.3350/cmh.2022.0364 PG 17 WC Gastroenterology & Hepatology WE Science Citation Index Expanded (SCI-EXPANDED) SC Gastroenterology & Hepatology GA 9L3IO UT WOS:000941446200023 PM 36517001 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Keating, SE Chawla, Y De, A George, ES AF Keating, Shelley E. Chawla, Yogesh De, Arka George, Elena S. TI Lifestyle intervention for metabolic dysfunction-associated fatty liver disease: a 24-h integrated behavior perspective SO HEPATOLOGY INTERNATIONAL LA English DT Article DE Exercise; Diet; Nutrition; MAFLD; Mediterranean diet; Physical activity ID SHORT-SLEEP DURATION; PHYSICAL-ACTIVITY; WEIGHT-LOSS; CARDIORESPIRATORY FITNESS; HEPATIC STEATOSIS; PRACTICE GUIDANCE; EXERCISE; RISK; HEALTH; DIET AB Introduction The prevalence, health and socioeconomic burden of metabolic dysfunction-associated fatty liver disease (MAFLD) is growing, increasing the need for novel evidence-based lifestyle approaches. Lifestyle is the cornerstone for MAFLD management and co-existing cardiometabolic dysfunction. The aim of this review was to evaluate the evidence for lifestyle management of MAFLD, with a specific lens on 24-hour integrated behaviour and provide practical recommendations for implementation of the evidence.Results Weight loss >= 7-10% is central to lifestyle management; however, liver and cardiometabolic benefits are attainable with improved diet quality and exercise even without weight loss. Lifestyle intervention for MAFLD should consider an integrated '24-h' approach that is cognisant of diet, physical activity/exercise, sedentary behavior, smoking, alcohol intake and sleep. Dietary management emphasises energy deficit and improved diet quality, especially the Mediterranean diet, although sociocultural adaptations to meet preferences should be considered. Increasing physical activity and reducing sedentary behavior can prevent MAFLD, with strongest evidence in MAFLD supporting regular structured moderate-vigorous aerobic exercise for 150-240 min/week. Resistance training in addition to aerobic exercise should be considered and prioritised for those who are losing body mass via diet and/or pharmacological approaches and those with sarcopenia, to minimise bone and lean mass loss. Limited evidence suggests that sleep is important for MAFLD prevention. Emerging novel approaches to diet and exercise may address some of the key barriers to behaviour change (e.g. lack of time, access to resources and social support).Future Directions Large-scale multidisciplinary trials in people with MAFLD with long-term follow-up, that can be scaled up into mainstream healthcare, are required. Future management guidelines should consider the heterogeneity of MAFLD and specialised models of care that coordinate the health workforce to manage the increased and growing MAFLD population. C1 [Keating, Shelley E.] Univ Queensland, Sch Human Movement & Nutr Sci, Brisbane, Qld, Australia. [Chawla, Yogesh] Kalinga Inst Med Sci KIMS, Bhubaneswar, India. [De, Arka] Postgrad Inst Med Educ & Res, Chandigarh, India. [George, Elena S.] Deakin Univ, Inst Phys Act & Nutr, Sch Exercise & Nutr Sci, Geelong, Australia. C3 University of Queensland; Kalinga Institute of Industrial Technology (KIIT); Post Graduate Institute of Medical Education & Research (PGIMER), Chandigarh; Deakin University RP Keating, SE (通讯作者)，Univ Queensland, Sch Human Movement & Nutr Sci, Brisbane, Qld, Australia. 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PD OCT PY 2024 VL 18 IS SUPPL 2 SU 2 SI SI BP 959 EP 976 DI 10.1007/s12072-024-10663-9 EA MAY 2024 PG 18 WC Gastroenterology & Hepatology WE Science Citation Index Expanded (SCI-EXPANDED) SC Gastroenterology & Hepatology GA H8I6Y UT WOS:001216114500003 PM 38717691 OA Green Submitted, hybrid DA 2026-02-02 ER PT J AU Lujan, PV Esmel, EV Meseguer, ES AF Vancells Lujan, Pau Vinas Esmel, Esther Sacanella Meseguer, Emilio TI Overview of Non-Alcoholic Fatty Liver Disease (NAFLD) and the Role of Sugary Food Consumption and Other Dietary Components in Its Development SO NUTRIENTS LA English DT Review DE NAFLD; NASH; nutrition; diabetes; metabolic syndrome; cardiovascular disease; fructose; fatty acids; protein; Mediterranean diet ID PLANT-BASED DIETS; HEPATIC STEATOSIS; GUT MICROBIOTA; WEIGHT-LOSS; FRUCTOSE RESTRICTION; MEDITERRANEAN DIET; PHYSICAL-ACTIVITY; HEALTH-BENEFITS; KETOGENIC DIET; SATURATED FAT AB NAFLD is the world's most common chronic liver disease, and its increasing prevalence parallels the global rise in diabetes and obesity. It is characterised by fat accumulation in the liver evolving to non-alcoholic steatohepatitis (NASH), an inflammatory subtype that can lead to liver fibrosis and cirrhosis. Currently, there is no effective pharmacotherapeutic treatment for NAFLD. Treatment is therefore based on lifestyle modifications including changes to diet and exercise, although it is unclear what the most effective form of intervention is. The aim of this review, then, is to discuss the role of specific nutrients and the effects of different dietary interventions on NAFLD. It is well established that an unhealthy diet rich in calories, sugars, and saturated fats and low in polyunsaturated fatty acids, fibre, and micronutrients plays a critical role in the development and progression of this disease. However, few clinical trials have evaluated the effects of nutrition interventions on NAFLD. We, therefore, summarise what is currently known about the effects of macronutrients, foods, and dietary patterns on NAFLD prevention and treatment. Most current guidelines recommend low-calorie, plant-based diets, such as the Mediterranean diet, as the most effective dietary pattern to treat NAFLD. More clinical trials are required, however, to identify the best evidence-based dietary treatment approach. C1 [Vancells Lujan, Pau; Vinas Esmel, Esther; Sacanella Meseguer, Emilio] Inst Invest Biomed August Pi i Sunyer IDIBAPS, Rossello 149, Barcelona 08036, Spain. [Vinas Esmel, Esther; Sacanella Meseguer, Emilio] Hosp Clin Barcelona, Dept Internal Med, Villarroel 170, Barcelona 08036, Spain. C3 University of Barcelona; Hospital Clinic de Barcelona; IDIBAPS; University of Barcelona; Hospital Clinic de Barcelona RP Meseguer, ES (通讯作者)，Inst Invest Biomed August Pi i Sunyer IDIBAPS, Rossello 149, Barcelona 08036, Spain.; Meseguer, ES (通讯作者)，Hosp Clin Barcelona, Dept Internal Med, Villarroel 170, Barcelona 08036, Spain. 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Catalano, Daniela Martines, G. Fabio Pace, Patrizia Trovato, Guglielmo M. TI Mediterranean diet and non-alcoholic fatty liver disease. The need of extended and comprehensive interventions SO CLINICAL NUTRITION LA English DT Article DE NAFLD; Mediterranean diet; Obesity; Insulin resistance; Physical activity ID NUTRITIONAL INTERVENTION; PHYSICAL-ACTIVITY; INDIVIDUALS; POPULATION; STEATOSIS; ADHERENCE; EXERCISE; NAFLD; BODY; RISK AB Background & aims: Non-alcoholic fatty liver disease (NAFLD) is mostly related to increased BMI and sedentary life, even if it not directly attributable only to these or to single specific factors. Unhealthy lifestyle and obesity are the most probable causes, also in non-diabetic and without alcohol abuse patients, even if lean individuals can be involved. NAFLD treatment is currently warranted and driven by comprehensive lifestyle intervention, a valuable objective that is more often wished for than actually achieved. The aim is to re-assess the effectiveness of an intervention focused to increase the Adherence to Mediterranean Diet Score (AMDS) and the level of physical exercise, investigating the factors associated with failure and reporting the time that must elapse before such intervention becomes effective. Methods: The study included 90 (F 46, M 44) non-alcoholic non-diabetic patients, aged 50.13 +/- 13.68 years, BMI 31.01 +/- 5.18 with evidence of fatty liver by ultrasound. Results: A significant decrease of Bright Liver Score (BLS) was observed only after 6 months of intervention: differently, at the first and third month of monitoring fatty liver changes were still not significant. By a multiple linear regression model Adherence to Mediterranean Diet change (p:0.015) and body mass index changes (p:<0.0001) independently explain the variance of decrease of fatty liver involvement (R2 = 0.519; p < 0.0001). Conclusion: Adherence to Mediterranean Diet is a significant predictor of changes in the fat content of the liver in overweight patients with NAFLD. The effect of the diet is gradual and favorable and it is independent of other lifestyle changes. (C) 2014 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved. C1 [Trovato, Francesca M.; Catalano, Daniela; Martines, G. Fabio; Pace, Patrizia; Trovato, Guglielmo M.] Univ Catania, Dept Med & Pediat Sci, I-95131 Catania, Italy. C3 University of Catania RP Trovato, GM (通讯作者)，Univ Catania, Dept Med & Pediat Sci, I-95131 Catania, Italy. EM guglielmotrovato@unict.it RI ; Catalano, Daniela/J-2883-2012 OI Trovato, Francesca Maria/0000-0002-8048-1646; Trovato, Guglielmo M/0000-0002-1168-1919; CR BAECKE JAH, 1982, AM J CLIN NUTR, V36, P936 Barrera F, 2014, CLIN LIVER DIS, V18, P91, DOI 10.1016/j.cld.2013.09.009 Brown TM, 2012, CLIN GASTROENTEROL H, V10, P568, DOI 10.1016/j.cgh.2012.02.023 Catalano D, 2008, LIVER INT, V28, P1280, DOI 10.1111/j.1478-3231.2008.01742.x Catalano D, 2013, AM J EMERG MED, V31, P1612, DOI 10.1016/j.ajem.2013.07.008 Catalano D, 2013, INT J CARDIOL, V168, P4408, DOI 10.1016/j.ijcard.2013.05.034 Catalano D, 2011, HEPATOL INT, V5, P822, DOI 10.1007/s12072-011-9254-2 Dai J, 2008, AM J CLIN NUTR, V88, P1364, DOI 10.3945/ajcn.2008.26528 Fung TT, 2009, CIRCULATION, V119, P1093, DOI 10.1161/CIRCULATIONAHA.108.816736 Kirk E, 2009, GASTROENTEROLOGY, V136, P1552, DOI 10.1053/j.gastro.2009.01.048 Kontogianni MD, 2013, CLIN NUTR Mascitelli L, 2013, J HEPATOL, V59, P639, DOI 10.1016/j.jhep.2013.03.041 Mathiesen UL, 2002, DIGEST LIVER DIS, V34, P516, DOI 10.1016/S1590-8658(02)80111-6 Ryan MC, 2013, J HEPATOL, V59, P138, DOI 10.1016/j.jhep.2013.02.012 Spencer MD, 2011, GASTROENTEROLOGY, V140, P976, DOI 10.1053/j.gastro.2010.11.049 Stuart-Shor EM, 2012, CIRCULATION, V125, P171, DOI 10.1161/CIRCULATIONAHA.110.968495 Trichopoulou A, 2003, NEW ENGL J MED, V348, P2599, DOI 10.1056/NEJMoa025039 Trovato GM, 2013, AM J GASTROENTEROL, V108, P1932, DOI 10.1038/ajg.2013.356 Trovato GM, 2013, J AM COLL CARDIOL, V62, P1036, DOI 10.1016/j.jacc.2013.03.066 Trovato GM, 2013, AM J EPIDEMIOL, V178, P661, DOI 10.1093/aje/kwt125 Younossi ZM, 2012, MEDICINE, V91, P319, DOI 10.1097/MD.0b013e3182779d49 NR 21 TC 108 Z9 127 U1 0 U2 24 PU CHURCHILL LIVINGSTONE PI EDINBURGH PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE, LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND SN 0261-5614 EI 1532-1983 J9 CLIN NUTR JI Clin. Nutr. PD FEB PY 2015 VL 34 IS 1 BP 86 EP 88 DI 10.1016/j.clnu.2014.01.018 PG 3 WC Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Nutrition & Dietetics GA CB4BZ UT WOS:000349574500014 PM 24529325 DA 2026-02-02 ER PT J AU Watzinger, C Nonnenmacher, T Grafetstätter, M Sowah, SA Ulrich, CM Kauczor, HU Kaaks, R Schübel, R Nattenmüller, J Kühn, T AF Watzinger, Cora Nonnenmacher, Tobias Grafetstaetter, Mirja Sowah, Solomon A. Ulrich, Cornelia M. Kauczor, Hans-Ullrich Kaaks, Rudolf Schuebel, Ruth Nattenmueller, Johanna Kuehn, Tilman TI Dietary Factors in Relation to Liver Fat Content: A Cross-sectional Study SO NUTRIENTS LA English DT Article DE non-alcoholic fatty liver disease; NAFLD; Mediterranean diet; DASH diet; food groups; MRI ID CALORIE RESTRICTION; MEDITERRANEAN DIET; DISEASE; RISK; INTERMITTENT; METAANALYSIS; CONSUMPTION; STEATOSIS; ADHERENCE; WEIGHT AB Non-alcoholic fatty liver disease (NAFLD) can lead to functional liver impairment and severe comorbidities. Beyond energy balance, several dietary factors may increase NAFLD risk, but human studies are lacking. The aim of this cross-sectional study was to investigate the associations between food consumption (47 food groups, derived Mediterranean and Dietary Approaches to Stop Hypertension (DASH) diet quality scores) and liver fat content (continuous scale and NAFLD, i.e., >5% liver fat content). Liver fat content was measured by magnetic resonance imaging (MRI) in 136 individuals (BMI: 25-40 kg/m(2), age: 35-65, 50.7% women) and food intake was recorded by food frequency questionnaires (FFQs). Associations between food items and liver fat were evaluated by multi-variable regression models. Intakes of cake and cookies as well legumes were inversely associated with liver fat content, while positive associations with intakes of high-fat dairy and cheese were observed. Only cake and cookie intake also showed an inverse association with NAFLD. This inverse association was unexpected, but not affected by adjustment for reporting bias. Both diet quality scores were inversely associated with liver fat content and NAFLD. Thus, as smaller previous intervention studies, our results suggest that higher diet quality is related to lower liver fat, but larger trials with iso-caloric interventions are needed to corroborate these findings. C1 [Watzinger, Cora; Grafetstaetter, Mirja; Sowah, Solomon A.; Kaaks, Rudolf; Schuebel, Ruth; Kuehn, Tilman] German Canc Res Ctr, Div Canc Epidemiol, Neuenheimer Feld 581, D-69120 Heidelberg, Germany. [Nonnenmacher, Tobias; Kauczor, Hans-Ullrich; Schuebel, Ruth; Nattenmueller, Johanna] Univ Hosp Heidelberg, Dept Diagnost & Intervent Radiol, Neuenheimer Feld 110, D-69120 Heidelberg, Germany. [Sowah, Solomon A.] Heidelberg Univ, Med Fac, D-69120 Heidelberg, Germany. [Ulrich, Cornelia M.] Huntsman Canc Inst, Salt Lake City, UT 84112 USA. [Ulrich, Cornelia M.] Univ Utah, Dept Populat Hlth Sci, Salt Lake City, UT 84112 USA. C3 Helmholtz Association; German Cancer Research Center (DKFZ); Ruprecht Karls University Heidelberg; Ruprecht Karls University Heidelberg; Utah System of Higher Education; University of Utah; Huntsman Cancer Institute; Utah System of Higher Education; University of Utah RP Watzinger, C; Kühn, T (通讯作者)，German Canc Res Ctr, Div Canc Epidemiol, Neuenheimer Feld 581, D-69120 Heidelberg, Germany. EM cora.watzinger@med.uni-muenchen.de; tno144@googlemail.com; m.grafetstaetter@dkfz-heidelberg.de; s.sowah@dkfz-heidelberg.de; neli@hci.utah.edu; Hans-Ulrich.Kauczor@med.uni-heidelberg.de; r.kaaks@Dkfz-Heidelberg.de; ruth.schuebel@gmx.de; johanna.nattenmueller@med.uni-heidelberg.de; t.kuehn@Dkfz-Heidelberg.de RI Nattenmueller, Johanna/GNH-5653-2022; Kühn, Tilman/JYP-5102-2024; Kauczor, Hans-Ulrich/AAU-5955-2021 OI Nattenmueller, Johanna/0000-0003-4032-378X; Sowah, Solomon/0000-0002-6183-9614; Kühn, Tilman/0000-0001-7702-317X; FU Helmholtz Association of German Research Centers (Cross-Program Topic: Metabolic Dysfunction); Stiftung zur Forderung der Erforschung der Zivilisationserkrankungen FX The HELENA Trial was sponsored by the Helmholtz Association of German Research Centers (Cross-Program Topic: Metabolic Dysfunction). Magnetic resonance imaging examinations were performed in the Department of Diagnostic and Interventional Radiology, Heidelberg University Hospital, and sponsored by the Stiftung zur Forderung der Erforschung der Zivilisationserkrankungen. 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Six randomized controlled trials were selected for the meta-analysis (sample size: 250 participants). In the meta-analysis, there was no significant difference in body mass index and waist circumference between the Med-Diet and control groups. Med-Diet significantly reduced fatty liver index (FLI) compared with the control diet (standard mean difference [SMD]: -1.06; 95% CI: -1.95 to -0.17; p =0.02). Med-Diet significantly reduced homeostasis model assessment of insulin resistance (HOMA-IR) compared with the control diet (SMD: -0.34; 95% CI: -0.65 to -0.03; p =0.03). Similarly, a meta-regression analysis using age showed that Med-Diet significantly reduced FLI and HOMA-IR (95% CI: -0.956 to -0.237, p =0.001 and 95% CI: -0.713 to -0.003, p =0.048, respectively). This meta-analysis demonstrated that Med-Diet improved hepatic steatosis and insulin resistance in patients with NAFLD. Thus, Med-Diet is a beneficial pharmaconutritional therapy in patients with NAFLD. C1 [Kawaguchi, Takumi; Yamamura, Sakura; Nakano, Dan; Tsutsumi, Tsubasa; Torimura, Takuji] Kurume Univ, Div Gastroenterol, Dept Med, Sch Med, Kurume, Fukuoka, Japan. [Charlton, Michael; Zafer, Maryam] Univ Chicago Med, Dept Med, Ctr Liver Dis, Chicago, IL USA. [Kawaguchi, Atsushi] Saga Univ, Sect Clin Cooperat Syst, Ctr Comprehens Community Med, Fac Med, Saga, Japan. C3 Kurume University; University of Chicago; Saga University RP Charlton, M (通讯作者)，Univ Chicago Med, Ctr Liver Dis, 5841 S Maryland Ave, Chicago, IL 60637 USA. EM mcharlton@medicine.bsd.uchicago.edu RI 中野, 暖/IYJ-2642-2023 OI Charlton, Michael/0000-0002-8258-4542; Tsutsumi, Tsubasa/0000-0001-6571-9874 FU Research Program on Hepatitis from Japan Agency for Medical Research and Development (AMED) [JP20fk0210040] FX This research is supported by the Research Program on Hepatitis from Japan Agency for Medical Research and Development (AMED) under grant number JP20fk0210040. 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Liver Dis. PD AUG PY 2021 VL 41 IS 03 BP 225 EP 234 DI 10.1055/s-0041-1723751 EA JUN 2021 PG 10 WC Gastroenterology & Hepatology WE Science Citation Index Expanded (SCI-EXPANDED) SC Gastroenterology & Hepatology GA TQ5AB UT WOS:000663404300001 PM 34147036 DA 2026-02-02 ER PT J AU Langmann, F Jensen, CF Mortensen, VL Rosendal, L Bock, N Dahm, CC AF Langmann, Fie Jensen, Christopher Fisker Mortensen, Vibeke Lie Rosendal, Line Bock, Niels Dahm, Christina C. TI Consumption of Legumes and Risk of Metabolic Dysfunction-Associated Steatotic Liver Disease and Gallstones among Humans Aged 2+Years: A Scoping Review SO NUTRITION REVIEWS LA English DT Review DE dietary pulses; gallstone; hepatobiliary health; legumes; metabolic dysfunction-associated steatotic liver disease ID MEDITERRANEAN DIET; FOOD-INTAKE; CHOLESTEROL; CHOLECYSTECTOMY; PREVENTION; PATTERNS AB The aim of this study was to identify and map the literature regarding human consumption of legumes and potential relationships with metabolic dysfunction-associated steatotic liver disease (MASLD) and gallbladder diseases. Consuming legumes might reduce lipid accumulation in the liver, while potentially impeding the functionality of the bile duct and gallbladder. As dietary trends shift toward promoting legume consumption, exploring the positive and negative impacts on hepatobiliary health becomes crucial. This scoping review explored the intake of dietary pulses and legumes (excluding broader dietary patterns) and its relation to hepatobiliary diseases such as MASLD, gallstones, gallbladder removal, and gallbladder inflammation, among individuals above the age of 2 years. The reviewed material included textbooks, expert opinions, and the articles identified in searches in 4 databases (PubMed, CINAHL Complete, Embase, and Web of Science). In addition, unpublished studies and gray literature sources were sought out. Two reviewers independently extracted the data from each article. The synthesis of the results is here presented narratively by outcome. Of the 19 881 records retrieved, 29 were included-17 on MASLD and 12 on gallstones. Most studies were observational, but a few were narrative reviews. The results were extremely heterogeneous. The few high-quality studies on legume consumption and MASLD observed lower risk, as did the one high-quality study on legumes and gallstones. Most studies were of moderate to poor quality, and confidence in the findings was assessed as low. Legume consumption is likely to be associated with lower risk of MASLD. The association between legume consumption and gallstones was difficult to evaluate, due to the low number of high-quality studies. Further research is needed to draw firmer conclusions. C1 [Langmann, Fie; Jensen, Christopher Fisker; Mortensen, Vibeke Lie; Rosendal, Line; Bock, Niels; Dahm, Christina C.] Aarhus Univ, Fac Hlth, Dept Publ Hlth, Bartholins Alle 2, DK-8000 Aarhus, Denmark. C3 Aarhus University RP Dahm, CC (通讯作者)，Aarhus Univ, Fac Hlth, Dept Publ Hlth, Bartholins Alle 2, DK-8000 Aarhus, Denmark. EM ccd@ph.au.dk RI Dahm, Christina/G-9787-2014; Langmann, Fie/HMW-0769-2023 OI Dahm, Christina/0000-0003-0481-2893; Langmann, Fie/0000-0003-3474-9346; Bock, Niels/0009-0005-7373-1589; , Line Rosendal/0009-0003-9434-4890; Mortensen, Vibeke Lie/0009-0009-1439-7233; Jensen, Christopher Fisker/0000-0001-7150-2946 FU Graduate School of Health, Aarhus University, Aarhus, Denmark; Department of Public Health, Aarhus University, Aarhus, Denmark FX This study was supported by The Graduate School of Health, Aarhus University, Aarhus, Denmark, and the Department of Public Health, Aarhus University, Aarhus, Denmark. The funders had no role in the planning, designing, or conducting of the research. The views expressed in this publication are those of the authors. 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PD NOV PY 2025 VL 83 IS 11 BP 2209 EP 2224 DI 10.1093/nutrit/nuaf157 EA AUG 2025 PG 16 WC Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Nutrition & Dietetics GA 8KD9U UT WOS:001563276000001 PM 40880258 DA 2026-02-02 ER PT J AU Li, TF Zhao, JH Cao, HZ Han, X Lu, Y Jiang, FY Li, XX Sun, J Zhou, SY Sun, ZQ Wang, WL Ding, Y Li, X AF Li, Tengfei Zhao, Jianhui Cao, Haoze Han, Xin Lu, Ying Jiang, Fangyuan Li, Xinxuan Sun, Jing Zhou, Siyun Sun, Zhongquan Wang, Weilin Ding, Yuan Li, Xue TI Dietary patterns in the progression of metabolic dysfunction-associated fatty liver disease to advanced liver disease: a prospective cohort study SO AMERICAN JOURNAL OF CLINICAL NUTRITION LA English DT Article DE metabolic dysfunction-associated fatty liver disease; dietary pattern; chronic liver disease; severe liver disease; dietary intervention ID SULFUR MICROBIAL DIET; RISK AB Background: Metabolic dysfunction-associated fatty liver disease (MAFLD) is a significant health problem. Dietary intervention plays an important role in patients with MAFLD. Objectives: We aimed to provide a reference for dietary patterns in patients with MAFLD. Methods: The presence of MAFLD was determined in the United Kingdom Biobank cohort. Nine dietary pattern scores were derived from the dietary records. Multivariable Cox regression models were used to estimate the hazard ratios (HRs) and 95% confidence intervals (CIs). The contrast test was employed to calculate the heterogeneity across MAFLD statuses. Results: We identified 175,300 patients with MAFLD at baseline. Compared with non-MAFLD, MAFLD was significantly associated with chronic liver disease (CLD) (HR: 3.48; 95% CI: 3.15, 3.84), severe liver disease (SLD) (HR: 2.87; 95% CI: 2.63, 3.14), liver cancer (HR: 1.93; 95% CI: 1.67, 2.23), and liver-related death (LRD) (HR: 1.93; 95% CI: 1.67, 2.23). In the overall cohort, the alternate Mediterranean diet (aMED) (HRCLD: 0.53; 95% CI: 0.37, 0.76; HRSLD: 0.52; 95% CI: 0.37, 0.72), planetary health diet (PHD) (HRCLD: 0.62; 95% CI: 0.47, 0.81; HRSLD: 0.65; 95% CI: 0.51, 0.83), plant-based low-carbohydrate diet (pLCD) (HRCLD: 0.65; 95% CI: 0.49, 0.86; HRSLD: 0.66; 95% CI: 0.51, 0.85), and healthful plant-based diet index (hPDI) (HRCLD: 0.63; 95% CI: 0.47, 0.84; HRSLD: 0.61; 95% CI: 0.47, 0.78) were associated with a lower risk of CLD and SLD. Additionally, unhealthful plant-based diet index (uPDI) was associated with increased risk of CLD (HR: 1.42; 95% CI: 1.09,1.85), SLD (HR: 1.50; 95% CI: 1.19, 1.90), and LRD (HR: 1.88; 95% CI: 1.28-2.78). The aforementioned associations remained consistently strong within the MAFLD subgroup while exhibiting less pronounced in the non-MAFLD group. However, no significant heterogeneity was observed across different MAFLD statuses. Conclusions: These findings highlight the detrimental effects of MAFLD on the development of subsequent liver diseases and the importance of dietary patterns in managing MAFLD. C1 [Li, Tengfei; Cao, Haoze; Han, Xin; Sun, Zhongquan; Wang, Weilin; Ding, Yuan] Zhejiang Univ, Sch Med, Affiliated Hosp 2, Dept Hepatobiliary & Pancreat Surg, Hangzhou, Zhejiang, Peoples R China. [Li, Tengfei; Zhao, Jianhui; Lu, Ying; Jiang, Fangyuan; Li, Xinxuan; Sun, Jing; Zhou, Siyun; Li, Xue] Zhejiang Univ, Sch Publ Hlth, Sch Med, Dept Big Data Hlth Sci, Hangzhou, Zhejiang, Peoples R China. [Li, Tengfei; Zhao, Jianhui; Lu, Ying; Jiang, Fangyuan; Li, Xinxuan; Sun, Jing; Zhou, Siyun; Li, Xue] Zhejiang Univ, Affiliated Hosp 2, Sch Med, Hangzhou, Zhejiang, Peoples R China. [Li, Tengfei; Cao, Haoze; Han, Xin; Sun, Zhongquan; Wang, Weilin; Ding, Yuan] Key Lab Precis Diag & Treatment Hepatobiliary & Pa, Hangzhou, Zhejiang, Peoples R China. [Li, Tengfei; Cao, Haoze; Han, Xin; Sun, Zhongquan; Wang, Weilin; Ding, Yuan] Res Ctr Diag & Treatment Technol Hepatocellular Ca, Hangzhou, Zhejiang, Peoples R China. [Li, Tengfei; Cao, Haoze; Han, Xin; Sun, Zhongquan; Wang, Weilin; Ding, Yuan] Natl Innovat Ctr Fundamental Res Canc Med, Hangzhou, Zhejiang, Peoples R China. [Li, Tengfei; Cao, Haoze; Han, Xin; Sun, Zhongquan; Wang, Weilin; Ding, Yuan] Zhejiang Univ, Canc Ctr, Hangzhou, Zhejiang, Peoples R China. [Li, Tengfei; Cao, Haoze; Han, Xin; Sun, Zhongquan; Wang, Weilin; Ding, Yuan] ZJU Pujian Res & Dev Ctr Med Artificial Intelligen, Hangzhou, Zhejiang, Peoples R China. [Li, Xue] Univ Edinburgh, Usher Inst, Ctr Global Hlth, Edinburgh, Scotland. C3 Zhejiang University; Zhejiang University; Zhejiang University; Zhejiang University; University of Edinburgh RP Wang, WL; Ding, Y (通讯作者)，Zhejiang Univ, Sch Med, Affiliated Hosp 2, Dept Hepatobiliary & Pancreat Surg, Hangzhou, Zhejiang, Peoples R China.; Wang, WL; Ding, Y (通讯作者)，Key Lab Precis Diag & Treatment Hepatobiliary & Pa, Hangzhou, Zhejiang, Peoples R China.; Wang, WL; Ding, Y (通讯作者)，Res Ctr Diag & Treatment Technol Hepatocellular Ca, Hangzhou, Zhejiang, Peoples R China.; Wang, WL; Ding, Y (通讯作者)，Natl Innovat Ctr Fundamental Res Canc Med, Hangzhou, Zhejiang, Peoples R China.; Wang, WL; Ding, Y (通讯作者)，Zhejiang Univ, Canc Ctr, Hangzhou, Zhejiang, Peoples R China.; Wang, WL; Ding, Y (通讯作者)，ZJU Pujian Res & Dev Ctr Med Artificial Intelligen, Hangzhou, Zhejiang, Peoples R China. EM wam@zju.edu.cn; dingyuan@zju.edu.cn OI Zhao, Jianhui/0000-0001-7974-6769 FU Key Project of Traditional Chinese Medicine Science and Technology Plan of Zhejiang Province [GZY-ZJ-KJ-24077]; National Natural Science Foundation of China [82272860, 82072650]; Key Research and Development Program of Zhejiang Province [202121C03121]; Zhejiang University Basic Research Fund [226-2022-00037] FX YD was supported by the Key Project of Traditional Chinese Medicine Science and Technology Plan of Zhejiang Province (GZY-ZJ-KJ-24077) and the National Natural Science Foundation of China (No. 82001673 and No. 82272860) ; WLW was supported by the Key Research and Development Program of Zhejiang Province (No. 202121C03121) , the National Natural Science Foundation of China (No. 82072650) and the Zhejiang University Basic Research Fund (No. 226-2022-00037) . 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PD SEP PY 2024 VL 120 IS 3 BP 518 EP 527 DI 10.1016/j.ajcnut.2024.07.015 EA SEP 2024 PG 10 WC Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Nutrition & Dietetics GA G4P8A UT WOS:001316484700001 PM 39029661 OA Green Submitted, hybrid DA 2026-02-02 ER PT J AU Fang, YC Fang, ZY Li, ZW Yu, R Zhang, HM Wang, QW Cheng, XR Le, GW Wu, GQ AF Fang, Yucheng Fang, Ziyang Li, Ziwei Yu, Run Zhang, Haimeng Wang, Qinwen Cheng, Xiangrong Le, Guowei Wu, Guoqing TI The role of the gut-liver axis in modulating non-alcoholic fatty liver disease through dietary patterns and microecological agents SO FOOD BIOSCIENCE LA English DT Article DE Gut-liver axis; NAFLD; Dietary pattern; Microecological agents ID INTERNATIONAL SCIENTIFIC ASSOCIATION; TRIMETHYLAMINE-N-OXIDE; CALORIE RESTRICTION; CONSENSUS STATEMENT; MEDITERRANEAN DIET; INDUCED OBESITY; BILE-ACIDS; MICROBIOTA; BUTYRATE; SUPPLEMENTATION AB Non-alcoholic fatty liver disease (NAFLD) is a leading cause of chronic liver disease, closely associated with dyslipidemia, obesity, and diabetes. The gut-liver axis (GLA) plays a pivotal role in the pathogenesis of NAFLD, with dietary factors acting as key regulators that shape gut microbiota and mediate GLA, consequently impacting NAFLD and host health. While reviews on specific dietary patterns or components and their relationship with NAFLD have been published in the past five years, a comprehensive summary of these dietary factors and their effects on NAFLD via the GLA mechanism is lacking. This review aims to provide a comprehensive overview of this mechanism by analyzing GLA-dependent metabolites, including bile acids, short-chain fatty acids, choline, trimethylamine-N-oxide, endotoxin, ammonia, and amino acids. Additionally, the review summarizes the various dietary factors that influence NAFLD through the GLA, encompassing dietary patterns such as western-style diet, Mediterranean diet, methionine-restricted diet, calorie-restricted diet, and protein-restricted diet, as well as oral microecological agents such as probiotics, prebiotics, synbiotics, and postbiotics. The majority of these dietary interventions, except for the western-style diet and long-term protein-restricted diet, demonstrate positive effects on improving NAFLD. Furthermore, synbiotics and postbiotics have emerged as promising agents for amelio-rating NAFLD-associated liver inflammation and lipid accumulation. In conclusion, this review provides a detailed understanding of the GLA mechanism and presents multiple possibilities for the nutritional treatment of NAFLD. C1 [Fang, Yucheng; Fang, Ziyang; Li, Ziwei; Wu, Guoqing] Ningbo Univ, Hlth Sci Ctr, Sch Publ Hlth, Ningbo 315211, Zhejiang, Peoples R China. [Yu, Run; Zhang, Haimeng; Wang, Qinwen] Ningbo Univ, Hlth Sci Ctr, Sch Basic Med Sci, Ningbo 315211, Zhejiang, Peoples R China. [Cheng, Xiangrong; Le, Guowei; Wu, Guoqing] Jiangnan Univ, Sch Food Sci & Technol, Wuxi 214122, Jiangsu, Peoples R China. C3 Ningbo University; Ningbo University; Jiangnan University RP Wu, GQ (通讯作者)，Ningbo Univ, Hlth Sci Ctr, Sch Publ Hlth, Ningbo 315211, Zhejiang, Peoples R China. EM wgqabc114@126.com OI Wu, Guoqing/0000-0003-4812-8890 FU National Natural Science Foundation of China [82103836]; Natural Science Foundation of Zhejiang Province [LQ22H260002]; Introduction of Talents Research Project of Ningbo University [ZX2022000093]; Open Project Program of State Key Laboratory of Food Science and Resources, Jiangnan University, China [SKLF-KF-202111] FX This study was supported by National Natural Science Foundation of China (No. 82103836), the Natural Science Foundation of Zhejiang Province (No. LQ22H260002), the Introduction of Talents Research Project of Ningbo University (No. ZX2022000093), and Open Project Program of State Key Laboratory of Food Science and Resources, Jiangnan University, China (No. SKLF-KF-202111). 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PD DEC PY 2023 VL 56 AR 103335 DI 10.1016/j.fbio.2023.103335 EA NOV 2023 PG 15 WC Food Science & Technology WE Science Citation Index Expanded (SCI-EXPANDED) SC Food Science & Technology GA HS9M1 UT WOS:001161612500001 DA 2026-02-02 ER PT J AU Sripongpun, P Churuangsuk, C Bunchorntavakul, C AF Sripongpun, Pimsiri Churuangsuk, Chaitong Bunchorntavakul, Chalermrat TI Current Evidence Concerning Effects of Ketogenic Diet and Intermittent Fasting in Patients with Nonalcoholic Fatty Liver SO JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY LA English DT Review DE Nonalcoholic fatty liver disease; Ketogenic diet; Intermittent fasting; Lifestyle modification; Weight reduction ID CARBOHYDRATE-RESTRICTED DIET; HEPATIC STEATOSIS; BETA-HYDROXYBUTYRATE; INSULIN SENSITIVITY; MEDITERRANEAN DIET; LIFE-STYLE; DISEASE; INFLAMMATION; MANAGEMENT; GLUCOSE AB Nonalcoholic fatty liver disease (NAFLD) is emerging globally, while no therapeutic medication has been approved as an effective treatment to date, lifestyle intervention through dietary modification and physical exercise plays a critical role in NAFLD management. In terms of dietary modification, Mediterranean diet is the most studied dietary pattern and is recommended in many guidelines, however, it may not be feasible and affordable for many patients. Recently, a ketogenic diet and intermittent fasting have gained public attention and have been studied in the role of weight management. This article reviews specifically whether these trendy dietary patterns have an effect on NAFLD outcomes regarding intrahepatic fat content, fibrosis, and liver enzymes, the scientific rationales behind these particular dietary patterns, as well as the safety concerns in some certain patient groups. C1 [Sripongpun, Pimsiri] Prince Songkla Univ, Fac Med, Div Internal Med, Gastroenterol & Hepatol Unit, Hat Yai, Thailand. [Churuangsuk, Chaitong] Prince Songkla Univ, Fac Med, Div Internal Med, Nutr & Obes Management Unit, Hat Yai, Thailand. [Bunchorntavakul, Chalermrat] Rangsit Univ, Rajavithi Hosp, Dept Med, Div Gastroenterol & Hepatol, Bangkok, Thailand. C3 Prince of Songkla University; Prince of Songkla University; Rajavithi Hospital; Rangsit University RP Bunchorntavakul, C (通讯作者)，Rangsit Univ, Div Gastroenterol & Hepatol, Dept Med, Rajavithi Hosp,Coll Med, Phayathai Rd, Bangkok 10400, Thailand. 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Clin. Transl. Hepatol. PD JUL-AUG PY 2022 VL 10 IS 4 BP 730 EP 739 DI 10.14218/JCTH.2021.00494 EA MAY 2022 PG 10 WC Gastroenterology & Hepatology WE Science Citation Index Expanded (SCI-EXPANDED) SC Gastroenterology & Hepatology GA 4L6OK UT WOS:000814304700001 PM 36062288 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Abenavoli, L Peta, V Milic, N AF Abenavoli, Ludovico Peta, Valentina Milic, Natasa TI Lifestyle changes associated with a new antioxidant formulation in non-alcoholic fatty liver disease: a case series SO ANNALS OF HEPATOLOGY LA English DT Article DE Non-alcoholic fatty liver disease; Steatosis; Mediterranean diet; Antioxidant; Insulin resistance ID MILK THISTLE; STEATOHEPATITIS; EPIDEMIOLOGY; GUIDELINES; MANAGEMENT; PROTOPINE; SEVERITY; DIET AB Non-alcoholic fatty liver disease (NAFLD) is a relevant issue in public health owing to its epidemiological burden. It represents the most common chronic liver disease in the general population and is expected to increase in future as a result of an ageing population. The only currently recommended treatment for NAFLD is lifestyle modification. However, literature reports pre-clinical and clinical studies on the use of antioxidant supplementation in NAFLD. A new antioxidant complex, called Bilirel (BIL) (Pharmaluce, Republic of San Marino), have recently introduced in the Italian market. However no data are reported on his effects on liver steatosis. Here we report on a cases series of seven overweight patients with NAFLD, in which the association of an Italian Mediterranean diet, increased physical activity, and daily administration of two pills of BIL for 6 weeks, have induced the rapid improvement of fatty liver accumulation, glucose and lipid metabolism, and weight reduction. C1 [Abenavoli, Ludovico; Peta, Valentina] Magna Graecia Univ Catanzaro, Dept Hlth Sci, I-88100 Catanzaro, Italy. [Milic, Natasa] Univ Novi Sad, Dept Pharm, Novi Sad 21000, Serbia. C3 Magna Graecia University of Catanzaro; University of Novi Sad RP Abenavoli, L (通讯作者)，Magna Graecia Univ Catanzaro, Dept Hlth Sci, Viate Europa Germaneto, I-88100 Catanzaro, Italy. EM l.abenavoli@unicz.it RI MONTEBIANCO ABENAVOLI, Ludovico/J-4394-2019 OI MONTEBIANCO ABENAVOLI, Ludovico/0000-0002-5922-1524; Milić, Nataša/0000-0002-8595-6065 CR Abenavoli L, 2014, PANMINERVA MED, V56, P189 Abenavoli L, 2013, ANN HEPATOL, V12, P357, DOI 10.1016/S1665-2681(19)30997-4 Abenavoli L, 2010, PHYTOTHER RES, V24, P1423, DOI 10.1002/ptr.3207 Bae DS, 2012, BMB REP, V45, P108, DOI 10.5483/BMBRep.2012.45.2.108 Bellentani S, 2010, DIGEST DIS, V28, P155, DOI 10.1159/000282080 Cacciapuoti F, 2013, WORLD J HEPATOL, V5, P109, DOI 10.4254/wjh.v5.i3.109 Chalasani N, 2012, HEPATOLOGY, V55, P2005, DOI 10.1002/hep.25762 Day CP, 1998, GASTROENTEROLOGY, V114, P842, DOI 10.1016/S0016-5085(98)70599-2 De Lorenzo A, 2010, CURR PHARM DESIGN, V16, P814, DOI 10.2174/138161210790883561 Fan JG, 2011, J DIGEST DIS, V12, P38, DOI 10.1111/j.1751-2980.2010.00476.x Farrell GC, 2007, J GASTROEN HEPATOL, V22, P775, DOI 10.1111/j.1440-1746.2007.05002.x Fruci B, 2013, INT J MOL SCI, V14, P22933, DOI 10.3390/ijms141122933 Guerrero-Romero F, 2010, J CLIN ENDOCR METAB, V95, P3347, DOI 10.1210/jc.2010-0288 Hamaguchi M, 2007, AM J GASTROENTEROL, V102, P2708, DOI 10.1111/j.1572-0241.2007.01526.x Kalhan SC, 2011, CLIN SCI, V121, P179, DOI 10.1042/CS20110060 Loguercio C, 2012, FREE RADICAL BIO MED, V52, P1658, DOI 10.1016/j.freeradbiomed.2012.02.008 Loria P, 2010, DIGEST LIVER DIS, V42, P272, DOI 10.1016/j.dld.2010.01.021 MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883 Meng SX, 2013, EVID-BASED COMPL ALT, V2013, DOI [10.1155/2013/702196, 10.1155/2013/801457] Milic N, 2013, NAT PROD COMMUN, V8, P1801 Milic S, 2012, DIGEST DIS, V30, P158, DOI 10.1159/000336669 Nascimbeni F, 2013, J HEPATOL, V59, P859, DOI 10.1016/j.jhep.2013.05.044 Olthof MR, 2011, NUTR METAB, V8, DOI 10.1186/1743-7075-8-10 Oni ET, 2013, ATHEROSCLEROSIS, V230, P258, DOI 10.1016/j.atherosclerosis.2013.07.052 Paz G, 2013, J MOL ENDOCRINOL, V51, P167, DOI 10.1530/JME-13-0072 Ratziu V, 2010, J HEPATOL, V53, P372, DOI 10.1016/j.jhep.2010.04.008 Rouabhia S, 2014, EXPERT REV GASTROENT, V8, P343, DOI 10.1586/17474124.2014.894880 Sofi F, 2014, WORLD J GASTROENTERO, V20, P7339, DOI 10.3748/wjg.v20.i23.7339 Tarantino G, 2013, WORLD J GASTROENTERO, V19, P3375, DOI 10.3748/wjg.v19.i22.3375 Vrba J, 2011, TOXICOL LETT, V203, P135, DOI 10.1016/j.toxlet.2011.03.015 Williams KH, 2013, ENDOCR REV, V34, P84, DOI 10.1210/er.2012-1009 NR 31 TC 3 Z9 3 U1 0 U2 5 PU MEXICAN ASSOC HEPATOLOGY PI MEXICO PA PUNTE DE PIEDRA 150, COLONIA TORIELLO GUERRA, MEXICO, DF CP 14040, MEXICO SN 1665-2681 J9 ANN HEPATOL JI Ann. Hepatol. PD JAN-FEB PY 2015 VL 14 IS 1 BP 121 EP 126 DI 10.1016/S1665-2681(19)30809-9 PG 6 WC Gastroenterology & Hepatology WE Science Citation Index Expanded (SCI-EXPANDED) SC Gastroenterology & Hepatology GA CD2JM UT WOS:000350903700014 PM 25536650 OA Green Submitted, hybrid DA 2026-02-02 ER PT J AU Jerome, NE Edwards, NE Ding, QL AF Jerome, Nirupama Esther Edwards, Nancy E. Ding, Qinglan (Priscilla) TI Impact of Mediterranean Dietary Education on Symptoms for Adults at Risk for Nonalcoholic Fatty Liver Disease SO GASTROENTEROLOGY NURSING LA English DT Article ID LIFE AB This 2-month quasi-experimental study focused on the impact of education regarding the Mediterranean diet on symptoms for adults who are at risk for nonalcoholic fatty liver disease (NAFLD). The study was conducted on a sample of 28 adults who presented to Pinnacle clinical research for NAFLD screening via a fibroscan. These individuals who are at risk for NAFLD received a single 15-minute one-on-one in person education regarding the Mediterranean diet. The diet encourages fruits, vegetables, whole grains, legumes, nuts, seeds, fish, and olive oil. The results of the study showed that the Mediterranean diet education was associated with significant improvement of abdominal symptoms (t = 3.34, p = .03), improvement of fatigue symptoms (t = 5.88, p < .001), and decrease in hepatic steatosis (t = 5.77, p < .001). Our study suggests that the education on the Mediterranean diet may be associated with improvement of self-reported abdominal symptoms, fatigue, and steatosis score. C1 [Jerome, Nirupama Esther; Edwards, Nancy E.; Ding, Qinglan (Priscilla)] Purdue Univ, Sch Nursing, W Lafayette, IN USA. [Jerome, Nirupama Esther] Purdue Univ, Sch Nursing, Johnson Hall,Room 109, 502 N Univ St, W Lafayette, IN 47907 USA. C3 Purdue University System; Purdue University; Purdue University System; Purdue University RP Jerome, NE (通讯作者)，Purdue Univ, Sch Nursing, Johnson Hall,Room 109, 502 N Univ St, W Lafayette, IN 47907 USA. 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Eat smart Wong RJ, 2021, J CLIN GASTROENTEROL, V55, P891, DOI 10.1097/MCG.0000000000001409 Yamamura S, 2021, J GASTROEN HEPATOL, V36, P629, DOI 10.1111/jgh.15172 Younossi ZM, 2020, DIABETES CARE, V43, P283, DOI 10.2337/dc19-1113 NR 32 TC 2 Z9 2 U1 0 U2 0 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1042-895X EI 1538-9766 J9 GASTROENTEROL NURS JI Gastroenterol. Nurs. PD SEP-OCT PY 2023 VL 46 IS 5 BP 359 EP 370 DI 10.1097/SGA.0000000000000753 PG 12 WC Gastroenterology & Hepatology; Nursing WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI) SC Gastroenterology & Hepatology; Nursing GA T1ZG9 UT WOS:001076029300003 PM 37639568 DA 2026-02-02 ER PT J AU Pasta, A Formisano, E Calabrese, F Marabotto, E Furnari, M Bodini, G Torres, MCP Pisciotta, L Giannini, EG Zentilin, P AF Pasta, Andrea Formisano, Elena Calabrese, Francesco Marabotto, Elisa Furnari, Manuele Bodini, Giorgia Torres, Maria Corina Plaz Pisciotta, Livia Giannini, Edoardo Giovanni Zentilin, Patrizia TI From Dysbiosis to Hepatic Inflammation: A Narrative Review on the Diet-Microbiota-Liver Axis in Steatotic Liver Disease SO MICROORGANISMS LA English DT Review DE gut microbiota; gut-liver axis; dysbiosis; steatotic liver disease ID MEDITERRANEAN DIET; LOW-CARBOHYDRATE; GUT MICROBIOME; MECHANISMS; COMPONENTS; RESISTANCE; PROBIOTICS; FIBROSIS; OBESITY AB The gut microbiota has emerged as a critical player in metabolic and liver health, with its influence extending to the pathogenesis and progression of steatotic liver diseases. This review delves into the gut-liver axis, a dynamic communication network linking the gut microbiome and liver through metabolic, immunological, and inflammatory pathways. Dysbiosis, characterized by altered microbial composition, contributes significantly to the development of hepatic steatosis, inflammation, and fibrosis via mechanisms such as gut barrier dysfunction, microbial metabolite production, and systemic inflammation. Dietary patterns, including the Mediterranean diet, are highlighted for their role in modulating the gut microbiota, improving gut-liver axis integrity, and attenuating liver injury. Additionally, emerging microbiota-based interventions, such as fecal microbiota transplantation and bacteriophage therapy, show promise as therapeutic strategies for steatotic liver disease. However, challenges such as population heterogeneity, methodological variability, and knowledge gaps hinder the translational application of current findings. Addressing these barriers through standardized approaches and integrative research will pave the way for microbiota-targeted therapies to mitigate the global burden of steatotic liver disease. C1 [Pasta, Andrea; Calabrese, Francesco; Marabotto, Elisa; Furnari, Manuele; Bodini, Giorgia; Torres, Maria Corina Plaz; Giannini, Edoardo Giovanni; Zentilin, Patrizia] Univ Genoa, Dept Internal Med, Gastroenterol Unit, I-16132 Genoa, Italy. [Formisano, Elena; Pisciotta, Livia] Univ Genoa, Dept Internal Med, Dietet & Clin Nutr Unit, I-16132 Genoa, Italy. [Formisano, Elena; Calabrese, Francesco; Marabotto, Elisa; Furnari, Manuele; Bodini, Giorgia; Torres, Maria Corina Plaz; Pisciotta, Livia; Giannini, Edoardo Giovanni; Zentilin, Patrizia] IRCCS Osped Policlin San Martino, I-16132 Genoa, Italy. C3 University of Genoa; University of Genoa; University of Genoa; IRCCS AOU San Martino IST RP Zentilin, P (通讯作者)，Univ Genoa, Dept Internal Med, Gastroenterol Unit, I-16132 Genoa, Italy.; Zentilin, P (通讯作者)，IRCCS Osped Policlin San Martino, I-16132 Genoa, Italy. EM andreapasta93@gmail.com; elena.formisano@hsanmartino.it; calabrese.francesco.93@gmail.com; elisa.marabotto@unige.it; manuele.furnari@unige.it; giorgia.bodini@unige.it; mariacorina.plaztorres@edu.unige.it; livia.pisciotta@unige.it; egiannini@unige.it; pzentilin@unige.it RI , Livia Pisciotta/K-4378-2018; Furnari, Manuele/N-5545-2015; Formisano, Elena/AAO-9548-2021; Marabotto, Elisa/AAB-2874-2021; Bodini, Giorgia/AAC-2888-2019; Zentilin, Patrizia/AAH-4451-2020; Pasta, Anea/AAX-3013-2021; Giannini, Edoardo/E-1120-2012; Plaz Torres, Maria Corina/JBI-9165-2023 OI , Livia Pisciotta/0000-0001-7080-9807; Furnari, Manuele/0000-0001-6424-079X; Formisano, Elena/0000-0003-2585-4566; Marabotto, Elisa/0000-0003-4507-8605; Calabrese, Francesco/0009-0008-4706-1499; Bodini, Giorgia/0000-0002-8367-0338; Zentilin, Patrizia/0000-0002-9235-6308; Pasta, Anea/0000-0003-1791-4506; Giannini, Edoardo/0000-0001-8526-837X; Plaz Torres, Maria Corina/0000-0003-4257-1058 CR Ahmad S, 2018, JAMA NETW OPEN, V1, DOI 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Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND EI 2076-2607 J9 MICROORGANISMS JI Microorganisms PD FEB PY 2025 VL 13 IS 2 AR 241 DI 10.3390/microorganisms13020241 PG 19 WC Microbiology WE Science Citation Index Expanded (SCI-EXPANDED) SC Microbiology GA Y1S1G UT WOS:001430000600001 PM 40005608 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Chooi, YC Zhang, QA Magkos, F Ng, M Michael, N Wu, XR Volchanskaya, VSB Lai, XN Wanjaya, ER Elejalde, U Chan, CW Yap, CPL Wong, LH Lim, KJ Velan, SS Yaligar, J Muthiah, MD Chong, YS Loo, EXL Eriksson, JG AF Chooi, Yu Chung Zhang, Qinze Arthur Magkos, Faidon Ng, Maisie Michael, Navin Wu, Xiaorong Volchanskaya, Vera Sergeyevna Brok Lai, Xianning Wanjaya, Elvy Riani Elejalde, Untzizu Chan, Chew Yap, Clara Poh Lian Wong, Long Hui Lim, Kevin Junliang Velan, S. Sendhil Yaligar, Jadegoud Muthiah, Mark Dhinesh Chong, Yap Seng Loo, Evelyn Xiu Ling Eriksson, Johan G. TI Effect of an Asian-adapted Mediterranean diet and pentadecanoic acid on fatty liver disease: the TANGO randomized controlled trial SO AMERICAN JOURNAL OF CLINICAL NUTRITION LA English DT Article DE NAFLD; Weight loss; Pentadecanoic acid; C15; 0; Asian-adapted Mediterranean diet; Chinese female ID WEIGHT-LOSS; METABOLIC FUNCTION; EPIDEMIOLOGY; ASSOCIATION; MANAGEMENT; MODERATE; NAFLD AB Background: Weight loss is the most effective treatment for nonalcoholic fatty liver disease (NAFLD). There is evidence that the Mediterranean diets rich in unsaturated fatty acids and fiber have beneficial effects on weight homeostasis and metabolic risk factors in individuals with NAFLD. Studies have also shown that higher circulating concentrations of pentadecanoic acid (C15:0) are associated with a lower risk for NAFLD. Objectives: To examine the effects of a Mediterranean-like, culturally contextualized Asian diet rich in fiber and unsaturated fatty acids, with or without C15:0 supplementation, in Chinese females with NAFLD. Methods: In a double-blinded, parallel-design, randomized controlled trial, 88 Chinese females with NAFLD were randomly assigned to 1 of the 3 groups for 12 wk: diet with C15:0 supplementation (n = 31), diet without C15:0 supplementation (n = 28), or control (habitual diet and no C15:0 supplementation, n = 29). At baseline and after the intervention, body fat percentage, intrahepatic lipid content, muscle and abdominal fat, liver enzymes, cardiometabolic risk factors, and gut microbiome were assessed. Results: In the intention-to-treat analysis, weight reductions of 4.0 +/- 0.5 kg (5.3%), 3.4 +/- 0.5 kg (4.5%), and 1.5 +/- 0.5 kg (2.1%) were achieved in the diet-with-C15:0, diet without-C15:0, and the control groups, respectively. The proton density fat fraction (PDFF) of the liver decreased by 33%, 30%, and 10%, respectively. Both diet groups achieved significantly greater reductions in body weight, liver PDFF, total cholesterol, gamma-glutamyl transferase, and triglyceride concentrations compared with the control group. C15:0 supplementation reduced LDL-cholesterol further, and increased the abundance of Bifidobacterium adolescentis. Fat mass, visceral adipose tissue, subcutaneous abdominal adipose tissue (deep and superficial), insulin, glycated hemoglobin, and blood pressure decreased significantly in all groups, in parallel with weight loss. Conclusion: Mild weight loss induced by a Mediterranean-like diet adapted for Asians has multiple beneficial health effects in females with NAFLD. C15:0 supplementation lowers LDL-cholesterol and may cause beneficial shifts in the gut microbiome. Trial registration number: This trial was registered at the clinicaltrials.gov as NCT05259475. C1 [Chooi, Yu Chung; Zhang, Qinze Arthur; Ng, Maisie; Michael, Navin; Velan, S. Sendhil; Yaligar, Jadegoud; Chong, Yap Seng; Loo, Evelyn Xiu Ling; Eriksson, Johan G.] ASTAR, Singapore Inst Clin Sci SICS, Singapore, Singapore. [Magkos, Faidon] Univ Copenhagen, Dept Nutr Exercise & Sports, Frederiksberg, Denmark. [Ng, Maisie] ASTAR, Bioinformat Inst BII, Singapore, Singapore. [Wu, Xiaorong; Volchanskaya, Vera Sergeyevna Brok; Lai, Xianning; Wanjaya, Elvy Riani; Elejalde, Untzizu; Wong, Long Hui] Natl Univ Singapore NUS, Ctr Translat Med, WIL NUS Corp Lab, Singapore, Singapore. [Muthiah, Mark Dhinesh] Natl Univ Hlth Syst, Dept Gastroenterol & Hepatol, Singapore, Singapore. [Muthiah, Mark Dhinesh] Natl Univ Ctr Organ Transplantat, Singapore, Singapore. [Chong, Yap Seng] Natl Univ Singapore NUS, Yong Loo Lin Sch Med, Dept Obstet & Gynaecol, Singapore, Singapore. [Loo, Evelyn Xiu Ling] Natl Univ Singapore NUS, Yong Loo Lin Sch Med, Dept Paediat, Singapore, Singapore. [Loo, Evelyn Xiu Ling] Natl Univ Singapore NUS, Yong Loo Lin Sch Med, Human Potential Translat Res Programme, Singapore, Singapore. [Eriksson, Johan G.] Univ Helsinki, Dept Gen Practice & Primary Hlth Care, Helsinki, Finland. [Eriksson, Johan G.] Helsinki Univ Hosp, Helsinki, Finland. [Eriksson, Johan G.] Folkhalsan Res Ctr, Helsinki, Finland. C3 Agency for Science Technology & Research (A*STAR); A*STAR - Singapore Institute for Clinical Sciences (SICS); University of Copenhagen; Agency for Science Technology & Research (A*STAR); A*STAR - Bioinformatics Institute (BII); National University of Singapore; National University of Singapore; National University of Singapore; National University of Singapore; National University of Singapore; University of Helsinki; University of Helsinki; Helsinki University Central Hospital; Folkhalsan Research Center RP Chooi, YC; Eriksson, JG (通讯作者)，ASTAR, Singapore Inst Clin Sci SICS, Singapore, Singapore.; Wong, LH (通讯作者)，Natl Univ Singapore NUS, Ctr Translat Med, WIL NUS Corp Lab, Singapore, Singapore.; Eriksson, JG (通讯作者)，Univ Helsinki, Dept Gen Practice & Primary Hlth Care, Helsinki, Finland.; Eriksson, JG (通讯作者)，Helsinki Univ Hosp, Helsinki, Finland.; Eriksson, JG (通讯作者)，Folkhalsan Res Ctr, Helsinki, Finland. EM chooiyc@sics.a-star.edu.sg; kat.wonglonghui@sg.wilmar-intl.com; obgjge@nus.edu.sg RI Michael, Navin/HGF-2322-2022; Velan, S Sendhil/B-6374-2017; Magkos, Faidon/CAA-9939-2022 OI Chooi, Yu Chung/0000-0001-9288-7793; Velan, S Sendhil/0000-0002-4096-0722; Magkos, Faidon/0000-0002-1312-7364; Elejalde, Untzizu/0009-0006-0035-3916 FU Agency for Science, Technology and Research (A*STAR) under its IAF-ICP [I1701E0011] FX This research is supported by the Agency for Science, Technology and Research (A*STAR) under its IAF-ICP Funding (Award Number I1701E0011) . 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J. Clin. Nutr. PD MAR PY 2024 VL 119 IS 3 BP 788 EP 799 DI 10.1016/j.ajcnut.2023.11.013 EA MAR 2024 PG 12 WC Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Nutrition & Dietetics GA OR7W5 UT WOS:001209077600001 PM 38035997 OA hybrid HC Y HP N DA 2026-02-02 ER PT J AU Abenavoli, L Di Renzo, L Boccuto, L Alwardat, N Gratteri, S De Lorenzo, A AF Abenavoli, Ludovico Di Renzo, Laura Boccuto, Luigi Alwardat, Nuha Gratteri, Santo De Lorenzo, Antonino TI Health benefits of Mediterranean diet in nonalcoholic fatty liver disease SO EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY LA English DT Review DE Food; obesity; metabolism; Nicotera; microbiota; inflammation ID INFLAMMATORY GENE-EXPRESSION; RANDOMIZED CONTROLLED-TRIAL; CORONARY-HEART-DISEASE; ADEQUACY INDEX; METABOLIC SYNDROME; 25-YEAR MORTALITY; PHYSICAL-ACTIVITY; HIGH-RISK; OBESITY; POPULATION AB Introduction: Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease worldwide. Insulin resistance and obesity-related inflammatory status, associated with genetic, dietary, and lifestyle factors, are involved in its pathogenesis. There is no consensus concerning the pharmacological treatment of NAFLD. However, the international guidelines agree to define a dietetic nutritional management to achieve weight loss, as an essential component of any therapeutic strategy.Areas covered: An overview on the beneficial effects of the Mediterranean diet in the prevention and treatment of NAFLD.Expert commentary: On the basis of its components, the literature reports the beneficial effects of the Mediterranean diet in preventing major chronic diseases, including obesity, diabetes, cardiovascular diseases, and some forms of cancers. In recent years, a growing body of evidence has supported the idea that the Mediterranean diet, associated with physical activity and cognitive behavior therapy, may be the reference nutritional profile for the prevention and the treatment of NAFLD patients. C1 [Abenavoli, Ludovico] Magna Graecia Univ Catanzaro, Dept Hlth Sci, Viale Europa Germaneto, I-88100 Catanzaro, Italy. [Di Renzo, Laura; Alwardat, Nuha; De Lorenzo, Antonino] Univ Roma Tor Vergata, Dept Biomed & Prevent, Sect Clin Nutr & Nutrigen, Rome, Italy. [Boccuto, Luigi] Clemson Univ, Sch Hlth Res, Greenwood Genet Ctr, Clemson, SC USA. [Gratteri, Santo] Magna Graecia Univ Catanzaro, Dept Surg & Med Sci, Catanzaro, Italy. C3 Magna Graecia University of Catanzaro; University of Rome Tor Vergata; Clemson University; Greenwood Genetic Center; Magna Graecia University of Catanzaro RP Abenavoli, L (通讯作者)，Magna Graecia Univ Catanzaro, Dept Hlth Sci, Viale Europa Germaneto, I-88100 Catanzaro, Italy. 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Gastroenterol. Hepatol. PY 2018 VL 12 IS 9 BP 873 EP 881 DI 10.1080/17474124.2018.1503947 PG 9 WC Gastroenterology & Hepatology WE Science Citation Index Expanded (SCI-EXPANDED) SC Gastroenterology & Hepatology GA GQ8IX UT WOS:000441998000004 PM 30033779 DA 2026-02-02 ER PT J AU Pugliese, N Torres, MCP Petta, S Valenti, L Giannini, EG Aghemo, A AF Pugliese, Nicola Torres, Maria Corina Plaz Petta, Salvatore Valenti, Luca Giannini, Edoardo G. Aghemo, Alessio TI Is there an 'ideal' diet for patients with NAFLD? SO EUROPEAN JOURNAL OF CLINICAL INVESTIGATION LA English DT Review DE chronic liver disease; diet; dietary regimen; lifestyle intervention; nonalcoholic steatohepatitis ID FATTY LIVER-DISEASE; CALORIE-KETOGENIC DIET; MEDITERRANEAN DIET; WEIGHT-LOSS; METABOLIC SYNDROME; HEPATIC STEATOSIS; GLYCEMIC CONTROL; VISCERAL FAT; RISK; ASSOCIATION AB Nonalcoholic fatty liver disease (NAFLD) is a growing epidemic that encompasses three distinct clinical phenotypes: uncomplicated fatty liver, nonalcoholic steatohepatitis (NASH) and NASH-related cirrhosis with its complications, including hepatocellular carcinoma. To date, no pharmacological treatments have been approved and lifestyle modifications including reduced caloric intake targeting a 7%-10% weight loss from baseline assessment represent the standard approach. Mediterranean diet has been recommended as the best dietary pattern since it is easy to follow and, independently of caloric intake its nutritional components have beneficial metabolic effects that not only improve steatosis but also risk factors for cardiovascular events, the leading cause of morbidity/mortality in individuals with NAFLD. Other dietary patterns such as ketogenic diet and Dietary Approach to Stop Hypertension (DASH) diet can be used in patients with NAFLD. Recently, intermittent fasting diets have gained popularity among healthy individuals and have been proposed as a safe and effective treatment for the metabolic syndrome in experimental and in a few human studies. In this narrative review, we aim to summarize the evidence for the available dietary approaches for patients with NAFLD. C1 [Pugliese, Nicola; Aghemo, Alessio] Humanitas Univ, Dept Biomed Sci, Milan, Italy. [Pugliese, Nicola; Torres, Maria Corina Plaz; Aghemo, Alessio] Humanitas Res Hosp IRCCS, Div Internal Med & Hepatol, Dept Gastroenterol, Milan, Italy. [Torres, Maria Corina Plaz; Giannini, Edoardo G.] Univ Genoa, Gastroenterol Unit, Dept Internal Med, IRCCS Osped Policlin San Martino, Genoa, Italy. [Petta, Salvatore] Univ Palermo, Sect Gastroenterol & Hepatol, PROMISE, Palermo, Italy. [Valenti, Luca] Univ Milan, Dept Pathophysiol & Transplantat, Milan, Italy. [Valenti, Luca] Fdn IRCCS Ca Granda Osped Maggiore Policlin, Dept Transfus Med & Hematol, Milan, Italy. C3 Humanitas University; University of Genoa; IRCCS AOU San Martino IST; University of Palermo; University of Milan; IRCCS Ca Granda Ospedale Maggiore Policlinico RP Aghemo, A (通讯作者)，Humanitas Univ, Dept Biomed Sci, Milan, Italy.; Aghemo, A (通讯作者)，Humanitas Res Hosp IRCCS, Div Internal Med & Hepatol, Dept Gastroenterol, Milan, Italy. EM alessio.aghemo@hunimed.eu RI Plaz Torres, Maria Corina/JBI-9165-2023; Valenti, Luca/B-3695-2009; Pugliese, Nicola/ABC-7622-2020; Giannini, Edoardo/E-1120-2012; Aghemo, Alessio/ABE-5976-2021 OI Plaz Torres, Maria Corina/0000-0003-4257-1058; Valenti, Luca/0000-0001-8909-0345; Pugliese, Nicola/0000-0001-6466-1412; Giannini, Edoardo/0000-0001-8526-837X; Aghemo, Alessio/0000-0003-0941-3226 FU Ricerca Finalizzata Ministero della Salute [RF-2016-02364358]; CV PREVITAL; Innovative Medicines Initiative 2 joint undertaking of European Union's Horizon 2020 research and innovation programme; EFPIA [777377]; European Union (EU) Programme Horizon 2020 Programme [101016726']; Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico `Ricerca Corrente'; Fondazione Sviluppo Ca' Granda for the project `Liver-BIBLE' [PR--0391]; Fondazione IRCCS Ca' Granda `5permille' for `COVID--19 Biobank' [RC100017A]; [Gilead_IN-IT-989-5790] FX LV was supported by Gilead_IN-IT-989-5790; Ricerca Finalizzata Ministero della Salute: RF-2016-02364358 and CV PREVITAL; the Innovative Medicines Initiative 2 joint undertaking of European Union's Horizon 2020 research and innovation programme and EFPIA for the project LITMUS under grant agreement No. 777377; the European Union (EU) Programme Horizon 2020 Programme `Photonics' under grant agreement 101016726' for the project `REVEAL'; Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico `Ricerca Corrente', and Fondazione Sviluppo Ca' Granda for the project `Liver-BIBLE' (PR--0391), Fondazione IRCCS Ca' Granda `5permille' for `COVID--19 Biobank' (RC100017A) CR Abenavoli L, 2017, NUTRIENTS, V9, DOI 10.3390/nu9080870 Aller R, 2015, NUTR HOSP, V32, P2518 Angulo P, 2015, GASTROENTEROLOGY, V149, P389, DOI 10.1053/j.gastro.2015.04.043 Ash S, 2003, INT J OBESITY, V27, P797, DOI 10.1038/sj.ijo.0802295 Asrih M, 2014, CLIN NUTR, V33, P186, DOI 10.1016/j.clnu.2013.11.003 Bedogni G, 2006, BMC GASTROENTEROL, V6, DOI 10.1186/1471-230X-6-33 Cai H, 2019, BMC GASTROENTEROL, V19, DOI 10.1186/s12876-019-1132-8 Chalasani N, 2012, HEPATOLOGY, V55, P2005, DOI 10.1002/hep.25762 Cherla DV, 2020, SURG ENDOSC, V34, P2266, DOI 10.1007/s00464-019-07017-0 Chiavaroli L, 2019, NUTRIENTS, V11, DOI 10.3390/nu11020338 Drinda S, 2019, NUTRIENTS, V11, DOI 10.3390/nu11112601 Eckel RH, 2014, J AM COLL CARDIOL, V63, P2960, DOI 10.1016/j.jacc.2013.11.003 Eslam M, 2020, GASTROENTEROLOGY, V158, P1999, DOI 10.1053/j.gastro.2019.11.312 Etemadi A., 2020, CURR DEV NUTR, V4, P1413, DOI 10.1093/cdn/nzaa061_041 European Association for the Study of the Liver (EASL) ; 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J. Clin. Invest. PD MAR PY 2022 VL 52 IS 3 SI SI AR e13659 DI 10.1111/eci.13659 EA AUG 2021 PG 11 WC Medicine, General & Internal; Medicine, Research & Experimental WE Science Citation Index Expanded (SCI-EXPANDED) SC General & Internal Medicine; Research & Experimental Medicine GA YY0CT UT WOS:000679932700001 PM 34309833 OA Green Submitted, Bronze DA 2026-02-02 ER PT J AU Ahmed, A Maham, K Afzaal, M Saleem, MA Nadeem, M Saeed, F Hussain, M Al Jbawi, E AF Ahmed, Aftab Maham, Khadija Afzaal, Muhammad Saleem, Muhammad Awais Nadeem, Muhammad Saeed, Farhan Hussain, Muzzamal Al Jbawi, Entessar TI The consequences of poor dietary patterns on the proliferation of non-alcoholic fatty liver disease SO COGENT FOOD & AGRICULTURE LA English DT Review DE NAFLD; hepatitis; cirrhosis; insulin resistance; poor lifestyle; Mediterranean diets; M. Luisa Escudero-Gilete; Universidad de Sevilla; Spain; Biochemistry; Nutrition; Pharmaceutical Science; Pharmacology; Epidemiology; Immunology; Allied Health; Medicine ID VITAMIN-E TREATMENT; STOP HYPERTENSION DASH; MEDITERRANEAN DIET; HEPATIC STEATOSIS; LOW-CARBOHYDRATE; FRUCTOSE; STEATOHEPATITIS; RISK; METAANALYSIS; PROGRESSION AB Triglyceride (TG) buildup in the liver is a hallmark of the metabolic disorder of non-alcoholic fatty liver disease (NAFLD). The four pathogenic categories mainly followed by the NAFLD pathway are hepatocellular carcinoma, non-alcoholic steatosis, steatohepatitis, and progressive fibrosis or cirrhosis. The likelihood of developing NAFLD rises with obesity and insulin resistance. Aging, gender, culture, and ethnicity are all associated with NAFLD, which substantially correlates to liver disorders in both kids and adults. It is prevalent throughout all age ranges. Visceral obesity appears to be exacerbated by poor lifestyle choices such as hypercaloric diets, particularly those high in trans-fat or saturated fat and cholesterol, and sugar-sweetened beverages. Decreasing calorie intake, boosting soy protein and whey ingestion, supplementing with monounsaturated fats, omega-3 fatty acids, and fiber, and changing one's lifestyle are the initial steps in managing this condition. Polyphenolic substances also have both therapeutic and preventative benefits. Activity and exercise that promotes weight loss and lessen liver fat formation are just as important as maintaining a balanced diet. The patients turn into susceptible to liver transplantation owing to improper concern (the end stage of NAFLD). Examining the impact of nutrition on nonalcoholic fatty liver disease (NAFLD) is the goal of this review. Included in this is a result of an unbalanced intake of macronutrients. The pathogenesis of NAFLD involves nutrition. Individuals with NAFLD must be recommended to restrict calorie consumption and set intake limits when following low-fat/carbohydrate diets. C1 [Ahmed, Aftab; Maham, Khadija; Saleem, Muhammad Awais] Govt Coll Univ Faisalabad, Dept Nutr Sci, Faisalabad, Pakistan. [Afzaal, Muhammad; Saeed, Farhan; Hussain, Muzzamal] Govt Coll Univ Faisalabad, Dept Food Sci, Faisalabad, Pakistan. [Nadeem, Muhammad] Univ Sargodha, Inst Food Sci & Nutr, Sargodha, Pakistan. [Al Jbawi, Entessar] MAAR, Agr Extens Directorate, Damascus, Syria. C3 Government College University Faisalabad; Government College University Faisalabad; University of Sargodha RP Ahmed, A (通讯作者)，Govt Coll Univ Faisalabad, Dept Nutr Sci, Faisalabad, Pakistan.; Hussain, M (通讯作者)，Govt Coll Univ Faisalabad, Dept Food Sci, Faisalabad, Pakistan.; Al Jbawi, E (通讯作者)，MAAR, Agr Extens Directorate, Damascus, Syria. 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PD DEC 31 PY 2024 VL 10 IS 1 AR 2325206 DI 10.1080/23311932.2024.2325206 PG 18 WC Agriculture, Multidisciplinary WE Science Citation Index Expanded (SCI-EXPANDED) SC Agriculture GA LE4H8 UT WOS:001185086500001 OA gold DA 2026-02-02 ER PT J AU Montemayor, S Bouzas, C Mascaró, CM Casares, M Llompart, I Abete, I Angullo-Martinez, E Zulet, MA Martínez, JA Tur, JA AF Montemayor, Sofia Bouzas, Cristina Mascaro, Catalina M. Casares, Miguel Llompart, Isabel Abete, Itziar Angullo-Martinez, Escarlata Angeles Zulet, Maria Alfredo Martinez, J. Tur, Josep A. TI Effect of Dietary and Lifestyle Interventions on the Amelioration of NAFLD in Patients with Metabolic Syndrome: The FLIPAN Study SO NUTRIENTS LA English DT Article DE NAFLD; metabolic syndrome; physical activity; intrahepatic fat contents; Mediterranean diet; FLIPAN ID FATTY LIVER-DISEASE; PHYSICAL-ACTIVITY QUESTIONNAIRE; MEDITERRANEAN DIET; AMERICAN ASSOCIATION; HYPOCALORIC DIETS; BEAN CONSUMPTION; LIPID PROFILES; WEIGHT-LOSS; SUPPLEMENTATION; OVERWEIGHT AB Background: Adults with fatty liver present unusual glycaemia and lipid metabolism; as a result, non-alcoholic fatty liver disease (NAFLD) is now considered as part of the metabolic syndrome (MetS). Objective: To assess the 6- and 12-month effects of customized hypocaloric dietary and enhanced physical activity intervention on intrahepatic fat contents and progression of NAFLD, in patients with MetS. Design: Cross-sectional study in 155 participants (40-60 years old) from Balearic Islands and Navarra (Spain) with a diagnosis of NAFLD and MetS, and BMI (body mass index) between 27 and 40 kg/m(2); patients were randomized in a 1:1:1 ratio to either Conventional Diet, Mediterranean diet (MD)-high meal frequency, and MD-physical activity groups. Methods: Dietary intake was assessed using a validated food frequency questionnaire. Adherence to Mediterranean diet, anthropometrics, physical activity, and biochemical parameters (fasting glucose, glycated hemoglobin, bilirubin, aspartate aminotransferase, alanine aminotransferase-ALT-, gamma-glutamyl transferase, uric acid, urea, creatinine, albumin, total cholesterol, high-density lipoprotein cholesterol-HDL-cholesterol-, and triglycerides) were also assessed. Results: Subjects with NAFLD and MetS had reduced intrahepatic fat contents, and liver stiffness, despite the intervention the participants went through. All participants ameliorated BMI, insulin, Hb1Ac, diastolic blood pressure, HDL-cholesterol, and ALT, and improved consumption of total energy, fish, and legumes. Participants in the MD-HMF group improved waist circumference. Conclusions: Customized hypocaloric dietary and enhanced physical activity interventions may be useful to ameliorate NAFLD. C1 [Montemayor, Sofia; Bouzas, Cristina; Mascaro, Catalina M.; Llompart, Isabel; Angullo-Martinez, Escarlata; Tur, Josep A.] Univ Balearic Isl IUNICS, Res Grp Community Nutr & Oxidat Stress, Palma De Mallorca 07122, Spain. [Montemayor, Sofia; Bouzas, Cristina; Mascaro, Catalina M.; Llompart, Isabel; Angullo-Martinez, Escarlata; Tur, Josep A.] Hlth Inst Balearic Isl IDISBA, Palma De Mallorca 07120, Spain. [Bouzas, Cristina; Abete, Itziar; Angeles Zulet, Maria; Tur, Josep A.] Inst Salud Carlos III ISCIII, CIBEROBN Physiopathol Obes & Nutr CB12 03 30038, Madrid 28029, Spain. [Casares, Miguel] Red Asistencial Juaneda, Radiodiag Serv, Palma De Mallorca 07011, Spain. [Llompart, Isabel] Univ Hosp Son Espases, Clin Anal Serv, Palma De Mallorca 07120, Spain. [Abete, Itziar; Angeles Zulet, Maria; Alfredo Martinez, J.] Univ Navarra, Ctr Nutr Res, Dept Nutr Food Sci & Physiol, Pamplona 31008, Spain. [Angullo-Martinez, Escarlata] Escola Graduada Primary Hlth Care Ctr, Palma De Mallorca 07001, Spain. [Alfredo Martinez, J.] CEI UAM CSIC, IMDEA Food, Cardiomet Precis Nutr Program, Madrid 28049, Spain. C3 CIBER - Centro de Investigacion Biomedica en Red; CIBEROBN; Hospital Universitari Son Espases; University of Navarra; Consejo Superior de Investigaciones Cientificas (CSIC); IMDEA Food Institute RP Tur, JA (通讯作者)，Univ Balearic Isl IUNICS, Res Grp Community Nutr & Oxidat Stress, Palma De Mallorca 07122, Spain.; Tur, JA (通讯作者)，Hlth Inst Balearic Isl IDISBA, Palma De Mallorca 07120, Spain.; Tur, JA (通讯作者)，Inst Salud Carlos III ISCIII, CIBEROBN Physiopathol Obes & Nutr CB12 03 30038, Madrid 28029, Spain. EM sofiamf16@gmail.com; cristina.bouzas@uib.es; c.mascaro@uib.es; casaresmiguel@gmail.com; isabel.11ompart@ssib.es; iabetego@unav.es; eangullo@ibsalut.caib.es; mazulet@unav.es; jalfredo.martinez@imdea.org; pep.tur@uib.es RI ; Zulet, M Angeles/H-1317-2017; Tur, Josep/AAE-5748-2020; Abete, Itziar/H-4827-2017; Martínez, J./K-8709-2014; Bouzas, Cristina/AAE-2069-2019 OI Montemayor, Sofía/0000-0001-7833-2118; Bouzas Velasco, Cristina/0000-0002-1407-8461; Zulet, M Angeles/0000-0002-3926-0892; Tur, Josep/0000-0002-6940-0761; Abete, Itziar/0000-0002-6475-5387; ANGULLO-MARTINEZ, ESCARLATA/0000-0001-7497-1123; FU Fundacio La Marato TV3 (Spain) [201630.10]; Instituto de Salud Carlos III through the CIBEROBN [CB12/03/30038, OBN18PI03]; European Regional Development Fund; Spanish Ministry of Education; IDISBA grants FX Fundacio La Marato TV3 (Spain) project ref. 201630.10. Instituto de Salud Carlos III through the CIBEROBN CB12/03/30038, and Proyecto Intramural CIBER OBN18PI03, which are co-funded by the European Regional Development Fund. Other funding received: IDISBA grants (FOLIUM, PRIMUS, SYNERGIA, and LIBERI). Catalina M. Mascaro received an FPU PhD grant from the Spanish Ministry of Education. The funding sponsors had no role in the design of the study, in the collection, analyses, or interpretation of the data; in the writing of the manuscript, or in the decision to publish the results. 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Ness, Erik Kowdley, Kris V. TI Nutritional Approaches to Achieve Weight Loss in Nonalcoholic Fatty Liver Disease SO ADVANCES IN NUTRITION LA English DT Review DE nonalcoholic fatty liver disease; nonalcoholic steatohepatitis; liver disease; obesity; metabolic syndrome; type 2 diabetes; DASH diet; bariatric surgery ID HIGH-PROTEIN DIET; INCREASED INTESTINAL PERMEABILITY; RANDOMIZED CONTROLLED-TRIAL; IMPROVES HEPATIC STEATOSIS; Y GASTRIC BYPASS; TERM-FOLLOW-UP; BARIATRIC SURGERY; RISK-FACTORS; AMINOTRANSFERASE LEVELS; MEDITERRANEAN DIET AB Nonalcoholic fatty liver disease (NAFLD) can range in spectrum from simple hepatic steatosis to nonalcoholic steatohepatitis (NASH), which is characterized by lipotoxicity, hepatocellular ballooning, and inflammation and can progress to cirrhosis. Weight loss is the cornerstone treatment for NAFLD and NASH. Various randomized controlled trials have shown that weight loss of >= 5-10% leads to significant improvements in hepatic steatosis. Diets high in sodium and fructose have been implicated in the pathogenesis of NAFLD. Although some clinical studies suggest that an isocaloric high-fructose diet does not worsen NAFLD, these clinical studies are often short in duration. More recently, the Dietary Approaches to Stop Hypertension diet, a sodium-restricted diet, has been associated with less prevalence of NAFLD and has been shown to improve NAFLD. In addition, the Mediterranean diet has been promising in improving hepatic steatosis, and a larger randomized controlled trial is currently enrolling subjects. For those who are unable to pursue weight loss through dietary approaches, bariatric surgery has been shown to improve hepatic steatosis and steatohepatitis. This method has been variable in improving hepatic fibrosis. In conclusion, weight loss is crucial to the improvement of NAFLD and NASH, and patients should attempt various diets in an attempt to achieve weight loss. C1 [Hsu, Christine C.] Univ Penn, Div Gastroenterol, Philadelphia, PA 19104 USA. [Kowdley, Kris V.] Swedish Med Ctr, Swedish Liver Care Network, Seattle, WA USA. C3 University of Pennsylvania; Swedish Health Services RP Hsu, CC (通讯作者)，Univ Penn, Div Gastroenterol, Philadelphia, PA 19104 USA. EM christine.hsu@uphs.upenn.edu RI Kowdley, Kris/AAF-5202-2019 OI Hsu, Christine/0000-0001-8779-9422 FU Galectin; Gilead; Immuron; Intercept; NGM Biopharma; Tobira FX Financial research support was received from Galectin, Gilead, Immuron, Intercept, NGM Biopharma, and Tobira (KVK). 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Nutr. PD MAR PY 2017 VL 8 IS 2 BP 253 EP 265 DI 10.3945/an.116.013730 PG 13 WC Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Nutrition & Dietetics GA EQ5GC UT WOS:000398109500005 PM 28298270 OA Bronze DA 2026-02-02 ER PT J AU Rinaldi, L Pafundi, PC Galiero, R Caturano, A Morone, MV Silvestri, C Giordano, M Salvatore, T Sasso, FC AF Rinaldi, Luca Pafundi, Pia Clara Galiero, Raffaele Caturano, Alfredo Morone, Maria Vittoria Silvestri, Chiara Giordano, Mauro Salvatore, Teresa Sasso, Ferdinando Carlo TI Mechanisms of Non-Alcoholic Fatty Liver Disease in the Metabolic Syndrome. A Narrative Review SO ANTIOXIDANTS LA English DT Review DE NAFLD; MAFLD; metabolic syndrome; insulin resistance; epigenetics; oxidative stress ID CARDIOVASCULAR RISK-FACTORS; NECROSIS-FACTOR-ALPHA; MEDITERRANEAN DIET; INSULIN-RESISTANCE; GUT MICROBIOTA; PHYSICAL-ACTIVITY; OXIDATIVE STRESS; WEIGHT-LOSS; CHOLESTEROL-METABOLISM; HEPATOCYTE APOPTOSIS AB Non-alcoholic fatty liver disease (NAFLD) and metabolic syndrome (MS) are two different entities sharing common clinical and physio-pathological features, with insulin resistance (IR) as the most relevant. Large evidence leads to consider it as a risk factor for cardiovascular disease, regardless of age, sex, smoking habit, cholesterolemia, and other elements of MS. Therapeutic strategies remain still unclear, but lifestyle modifications (diet, physical exercise, and weight loss) determine an improvement in IR, MS, and both clinical and histologic liver picture. NAFLD and IR are bidirectionally correlated and, consequently, the development of pre-diabetes and diabetes is the most direct consequence at the extrahepatic level. In turn, type 2 diabetes is a well-known risk factor for multiorgan damage, including an involvement of cardiovascular system, kidney and peripheral nervous system. The increased MS incidence worldwide, above all due to changes in diet and lifestyle, is associated with an equally significant increase in NAFLD, with a subsequent rise in both morbidity and mortality due to both metabolic, hepatic and cardiovascular diseases. Therefore, the slowdown in the increase of the "bad company" constituted by MS and NAFLD, with all the consequent direct and indirect costs, represents one of the main challenges for the National Health Systems. C1 [Rinaldi, Luca; Pafundi, Pia Clara; Galiero, Raffaele; Caturano, Alfredo; Silvestri, Chiara; Giordano, Mauro; Sasso, Ferdinando Carlo] Univ Campania Luigi Vanvitelli, Dept Adv Med & Surg Sci, Piazza Luigi Miraglia 2, I-80138 Naples, Italy. [Morone, Maria Vittoria] Univ Campania Luigi Vanvitelli, Dept Expt Med, Microbiol Sect, Piazza Luigi Miraglia 2, I-80138 Naples, Italy. [Salvatore, Teresa] Univ Campania Luigi Vanvitelli, Dept Precis Med, Via De Crecchio 7, I-80138 Naples, Italy. C3 Universita della Campania Vanvitelli; Universita della Campania Vanvitelli; Universita della Campania Vanvitelli RP Sasso, FC (通讯作者)，Univ Campania Luigi Vanvitelli, Dept Adv Med & Surg Sci, Piazza Luigi Miraglia 2, I-80138 Naples, Italy. EM luca.rinaldi@unicampania.it; piaclara.pafundi@unicampania.it; raffaele.galiero@unicampania.it; alfredo.caturano@unicampania.it; mariavittoria.morone@unicampania.it; teresa.salvatore@unicampania.it; mauro.giordano@unicampania.it; teresa.salvatore@unicampania.it; ferdinando.sasso@unicampania.it RI ; PAFUNDI, PIA CLARA/GLN-5679-2022; Sasso, Ferdinando Carlo/AAE-5665-2019; Morone, Maria Vittoria/MVX-5984-2025; Caturano, Alfredo/AAA-4014-2022; Galiero, Raffaele/KTP-8361-2024 OI Rinaldi, Luca/0000-0002-6541-3821; PAFUNDI, PIA CLARA/0000-0002-0310-3529; Sasso, Ferdinando Carlo/0000-0002-9142-7848; Morone, Maria Vittoria/0009-0000-0810-8460; Caturano, Alfredo/0000-0001-7761-7533; CR Abenavoli L, 2019, INT J ENV RES PUB HE, V16, DOI 10.3390/ijerph16173011 Acierno C, 2020, Exploration of Medicine, V1, DOI [10.37349/emed.2020.00019, 10.37349/emed.2020.0001, DOI 10.37349/EMED.2020.0001, 10.37349/emed.2020.00019, DOI 10.37349/EMED.2020.00019] Adinolfi LE, 2018, EXPERT REV ANTI-INFE, V16, P595, 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Cunningham, RP Dashek, RJ Mucinski, JM Rector, RS AF Moore, Mary P. Cunningham, Rory P. Dashek, Ryan J. Mucinski, Justine M. Rector, R. Scott TI A Fad too Far? Dietary Strategies for the Prevention and Treatment of NAFLD SO OBESITY LA English DT Review ID FATTY LIVER-DISEASE; ALANINE AMINOTRANSFERASE LEVELS; HEPATIC INSULIN-RESISTANCE; LIFE-STYLE CHANGES; HIGH-PROTEIN DIET; LOW-CARBOHYDRATE; MEDITERRANEAN DIET; KETOGENIC DIET; METABOLIC SYNDROME; GLYCEMIC INDEX AB Nonalcoholic fatty liver disease (NAFLD) is a major health problem, and its prevalence has increased in recent years, concurrent with rising rates of obesity and other metabolic diseases. Currently, there are no FDA-approved pharmacological therapies for NAFLD, and lifestyle interventions, including weight loss and exercise, remain the cornerstones for treatment. Manipulating diet composition and eating patterns may be a sustainable approach to NAFLD treatment. Dietary strategies including Paleolithic, ketogenic, Mediterranean, high-protein, plant-based, low-carbohydrate, and intermittent fasting diets have become increasingly popular because of their purported benefits on metabolic disease. This review highlights what is currently known about these popular dietary approaches in the management of NAFLD in clinical populations with mechanistic insight from animal studies. It also identifies key knowledge gaps to better inform future preclinical and clinical studies aimed at the treatment of NAFLD. C1 [Moore, Mary P.; Cunningham, Rory P.; Dashek, Ryan J.; Rector, R. Scott] Harry S Truman Mem Vet Hosp, Res Serv, Columbia, MO 65201 USA. [Moore, Mary P.; Cunningham, Rory P.; Mucinski, Justine M.; Rector, R. Scott] Univ Missouri, Dept Nutr & Exercise Physiol, Columbia, MO USA. [Dashek, Ryan J.] Univ Missouri, Comparat Med Program, Columbia, MO USA. [Rector, R. Scott] Univ Missouri, Div Gastroenterol & Hepatol, Columbia, MO USA. C3 US Department of Veterans Affairs; Veterans Health Administration (VHA); Harry S. Truman Memorial Veterans' Hospital; University of Missouri System; University of Missouri Columbia; University of Missouri System; University of Missouri Columbia; University of Missouri System; University of Missouri Columbia RP Rector, RS (通讯作者)，Harry S Truman Mem Vet Hosp, Res Serv, Columbia, MO 65201 USA.; Rector, RS (通讯作者)，Univ Missouri, Dept Nutr & Exercise Physiol, Columbia, MO USA.; Rector, RS (通讯作者)，Univ Missouri, Div Gastroenterol & Hepatol, Columbia, MO USA. EM rectors@health.missouri.edu RI ; Mucinski, Justine/GWV-4462-2022 OI Rector, R Scott/0000-0001-9908-7123; Mucinski, Justine/0000-0003-4432-6638; Moore, Mary P/0000-0002-6365-7718 FU VA-Merit grant [I01BX003271]; NIH [R01 DK113701-01]; NIH T32 [T32 OD011126]; National Institute of Diabetes and Digestive and Kidney Diseases [R01DK113701] Funding Source: NIH RePORTER; NIH Office of the Director [T32OD011126] Funding Source: NIH RePORTER FX RSR is supported by VA-Merit grant I01BX003271 and NIH R01 DK113701-01. RJD is supported by an NIH T32 (T32 OD011126). 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TI Prospective association between adherence to the Mediterranean diet and hepatic steatosis: the Swiss CoLaus cohort study SO BMJ OPEN LA English DT Article DE nutrition & dietetics; epidemiology; public health; hepatology ID FATTY LIVER-DISEASE; METABOLIC SYNDROME; PHYSICAL-ACTIVITY; RISK-FACTORS; INDEX; SEVERITY; PREVALENCE; VALIDATION; MANAGEMENT; REDUCTION AB Objective The Mediterranean diet has been promoted as a healthy dietary pattern, but whether the Mediterranean diet may help to prevent hepatic steatosis is not clear. This study aimed to evaluate the prospective association between adherence to the Mediterranean diet and risk of hepatic steatosis. Design Population-based prospective cohort study. Setting The Swiss CoLaus Study. Participants We evaluated 2288 adults (65.4% women, aged 55.8 +/- 10.0 years) without hepatic steatosis at first follow-up in 2009-2012. Adherence to the Mediterranean diet was scaled as the Mediterranean diet score (MDS) based on the Mediterranean diet pyramid ascertained with responses to Food Frequency Questionnaires. Outcome measures New onset of hepatic steatosis was ascertained by two indices separately: the Fatty Liver Index (FLI, >= 60 points) and the non-alcoholic fatty liver disease (NAFLD) score (>=-0.640 points). Prospective associations between adherence to the Mediterranean diet and risk of hepatic steatosis were quantified using Poisson regression. Results During a mean 5.3 years of follow-up, hepatic steatosis was ascertained in 153 (6.7%) participants by FLI criteria and in 208 (9.1%) by NAFLD score. After multivariable adjustment, higher adherence to MDS was associated with lower risk of hepatic steatosis based on FLI: risk ratio 0.84 (95% CI 0.73 to 0.96) per 1 SD of MDS; 0.85 (0.73 to 0.99) adjusted for BMI; and 0.85 (0.71 to 1.02) adjusted for both BMI and waist circumference. When using NAFLD score, no significant association was found between MDS and risk of hepatic steatosis (0.95 (0.83 to 1.09)). Conclusion A potential role of the Mediterranean diet in the prevention of hepatic steatosis is suggested by the inverse association observed between adherence to the Mediterranean diet and incidence of hepatic steatosis based on the FLI. The inconsistency of this association when hepatic steatosis was assessed by NAFLD score points to the need for accurate population-level assessment of fatty liver and its physiological markers. C1 [Khalatbari-Soltani, Saman] Univ Sydney, Sch Publ Hlth, Fac Med & Hlth, Sydney, NSW, Australia. [Khalatbari-Soltani, Saman] Univ Sydney, ARC Ctr Excellence Populat Ageing Res CEPAR, Sydney, NSW, Australia. [Khalatbari-Soltani, Saman; Marques-Vidal, Pedro] Univ Hosp Lausanne CHUV, Dept Internal Med, Internal Med, Lausanne, Switzerland. [Imamura, Fumiaki; Forouhi, Nita G.] Univ Cambridge, Sch Clin Med, Med Res Council Epidemiol Unit, Cambridge, England. C3 University of Sydney; University of Sydney; University of Lausanne; Centre Hospitalier Universitaire Vaudois (CHUV); UK Research & Innovation (UKRI); Medical Research Council UK (MRC); University of Cambridge RP Khalatbari-Soltani, S (通讯作者)，Univ Sydney, Sch Publ Hlth, Fac Med & Hlth, Sydney, NSW, Australia.; Khalatbari-Soltani, S (通讯作者)，Univ Sydney, ARC Ctr Excellence Populat Ageing Res CEPAR, Sydney, NSW, Australia.; Khalatbari-Soltani, S (通讯作者)，Univ Hosp Lausanne CHUV, Dept Internal Med, Internal Med, Lausanne, Switzerland.; Forouhi, NG (通讯作者)，Univ Cambridge, Sch Clin Med, Med Res Council Epidemiol Unit, Cambridge, England. EM saman.khalatbarisoltani@sydney.edu.au; nita.forouhi@mrc-epid.cam.ac.uk RI Marques-Vidal, Peo/C-9449-2009; Khalatbari-Soltani, Saman/M-7161-2014; Imamura, Fumiaki/J-1038-2019; Forouhi, Nita/JAC-2361-2023 OI Marques-Vidal, Peo/0000-0002-4548-8500; Khalatbari-Soltani, Saman/0000-0001-8437-1906; Imamura, Fumiaki/0000-0002-6841-8396; Forouhi, Nita/0000-0002-5041-248X FU GlaxoSmithKline; Faculty of Biology and Medicine of Lausanne; Swiss National Science Foundation [33CSCO-122661, 33CS30-139468, 33CS30-148401, P1LAP3-171805]; MRC [MC_UU_12015/5]; NIHR Biomedical Research Centre Cambridge: Nutrition, Diet and Lifestyle Research Theme [IS-BRC-1215-20014]; MRC [MC_UU_12015/5, MC_UU_00006/3] Funding Source: UKRI; Swiss National Science Foundation (SNF) [P1LAP3_171805] Funding Source: Swiss National Science Foundation (SNF); Medical Research Council [MC_UU_12015/5] Funding Source: researchfish FX The CoLaus Study was and is supported by research grants from GlaxoSmithKline, the Faculty of Biology and Medicine of Lausanne, and the Swiss National Science Foundation (grants 33CSCO-122661, 33CS30-139468 and 33CS30-148401). SK-S was supported by the Swiss National Science Foundation (Doc.Mobility number P1LAP3-171805). NGF and FI acknowledge core MRC support (MC_UU_12015/5), and NGF acknowledges NIHR Biomedical Research Centre Cambridge: Nutrition, Diet and Lifestyle Research Theme (IS-BRC-1215-20014). 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C3 Consejo Superior de Investigaciones Cientificas (CSIC); University of Sevilla; CSIC-JA-USE - Instituto de Biomedicina de Sevilla (IBIS); Virgen del Rocio University Hospital; Consejo Superior de Investigaciones Cientificas (CSIC); Universidad Pablo de Olavide; CSIC - Andalusian Center for Developmental Biology (CABD) RP Bustos, M (通讯作者)，Univ Seville, Spanish Natl Res Council CSIC, Inst Biomed Seville IBIS, Virgen Rocio Univ Hosp, Seville 41013, Spain.; López-Lluch, G (通讯作者)，Univ Pablo de Olavide, Ctr Andaluz Biol Desarrollo CABD CSIC JA, Inst Hlth Carlos III CIBERER, Seville 41013, Spain. EM dcarneros-ibis@us.es; glopllu@upo.es; mbustos-ibis@us.com RI ; López-Lluch, Guillermo/N-4742-2014; Bustos, Matilde/ACP-1674-2022; Carneros, David/NRX-9550-2025 OI Carneros Trujillo, David/0000-0001-5124-4708; López-Lluch, Guillermo/0000-0001-9830-8502; FU MINECO/AEI/FEDER, UE from the Ministry of Economy and Competitiveness (European Social Fund) [PID2019-110587RB-I00]; Andalusian Ministry of Economy, Innovation, Science and Employment [P18-RT-4775]; pre-doctoral iPFIS - Spanish Institute of Health Carlos III (European Social Fund) [IFI 19/00048] FX This research was funded by MINECO/AEI/FEDER, UE PID2019-110587RB-I00 from the Ministry of Economy and Competitiveness (co-funded by European Social Fund) to G.L.-L and M.B. and Andalusian Ministry of Economy, Innovation, Science and Employment (P18-RT-4775) to G.L.-L. and M.B. D.C. is supported by a pre-doctoral iPFIS, (IFI 19/00048) funded by the Spanish Institute of Health Carlos III (co-funded by European Social Fund). 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However, CR alone is not optimal and evidence suggests that dietary pattern and composition are also critical in NAFLD management. Accordingly, high consumption of red and processed meat, saturated fat, added sugar, and sweetened beverages are associated with an increased risk of developing NAFLD and hepatocellular carcinoma, while other foods and compounds such as fish, olive oil, and polyphenols are, in contrast, beneficial for metabolic disorders. Therefore, several dietary interventions have been studied in order to determine which strategy would be the most beneficial for NAFLD. The evidence regarding the effectiveness of different dietary interventions such as low carbohydrate/low-fat diet, time-restricted eating diet, CR, and the well-studied Mediterranean diet is summarized. C1 [Hadefi, Alia; Arvanitakis, Marianna; Trepo, Eric] Univ Libre Bruxelles, CUB Hop Erasme, Hop Univ Bruxelles HUB, Dept Gastroenterol Hepatopancreatol & Digest Onco, Brussels, Belgium. [Hadefi, Alia; Trepo, Eric] Univ Libre Bruxelles, Lab Expt Gastroenterol, Brussels, Belgium. [Zelber-Sagi, Shira] Univ Haifa, Fac Social Welf & Hlth Sci, Sch Publ Hlth, Haifa, Israel. [Zelber-Sagi, Shira] Tel Aviv Med Ctr & Sch Med, Dept Gastroenterol, Tel Aviv, Israel. C3 Universite Libre de Bruxelles; Universite Libre de Bruxelles; University of Haifa; Tel Aviv University; Sackler Faculty of Medicine RP Hadefi, A (通讯作者)，Univ Libre Bruxelles, CUB Hop Erasme, Hop Univ Bruxelles HUB, Dept Gastroenterol Hepatopancreatol & Digest Onco, Brussels, Belgium. 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J. PD SEP PY 2023 VL 11 IS 7 BP 663 EP 689 DI 10.1002/ueg2.12443 EA JUL 2023 PG 27 WC Gastroenterology & Hepatology WE Science Citation Index Expanded (SCI-EXPANDED) SC Gastroenterology & Hepatology GA S0ZP3 UT WOS:001035418900001 PM 37491835 OA Green Submitted, hybrid DA 2026-02-02 ER PT J AU Petermann-Rocha, F Carrasco-Marin, F Boonpor, J Parra-Soto, S Shannon, O Malcomson, F Phillips, N Jain, M Deo, S Livingstone, KM Dingle, SE Mathers, JC Forrest, E Ho, FK Pell, JP Celis-Morales, C AF Petermann-Rocha, Fanny Carrasco-Marin, Fernanda Boonpor, Jirapitcha Parra-Soto, Solange Shannon, Oliver Malcomson, Fiona Phillips, Nathan Jain, Mahek Deo, Salil Livingstone, Katherine M. Dingle, Sara E. Mathers, John C. Forrest, Ewan Ho, Frederick K. Pell, Jill P. Celis-Morales, Carlos TI Association of five diet scores with severe NAFLD incidence: A prospective study from UK Biobank SO DIABETES OBESITY & METABOLISM LA English DT Article DE diet; non-alcoholic fatty liver disease; incidence ID FATTY LIVER-DISEASE; MEDITERRANEAN DIET; PHYSICAL-ACTIVITY; PREVENTION; NUTRITION; FRUCTOSE; GLUCOSE AB Aim: This study aimed to contrast the associations of five common diet scores with severe non-alcoholic fatty liver disease (NAFLD) incidence.Materials and methods: In total, 162 999 UK Biobank participants were included in this prospective population-based study. Five international diet scores were included: the 14-Item Mediterranean Diet Adherence Screener (MEDAS-14), the Recommended Food Score (RFS), the Healthy Diet Indicator (HDI), the Mediterranean Diet Score and the Mediterranean-DASH Intervention for Neurodegenerative Delay score. As each score has different measurements and scales, all scores were standardized and categorized into quartiles. Cox proportional hazard models adjusted for confounder factors investigated associations between the standardized quartiles and severe NAFLD incidence.Results: Over a median follow-up of 10.2 years, 1370 participants were diagnosed with severe NAFLD. When the analyses were fully adjusted, participants in quartile 4 using the MEDAS-14 and RFS scores, as well as those in quartiles 2 and 3 using the HDI score, had a significantly lower risk of severe incident NAFLD compared with those in quartile 1. The lowest risk was observed in quartile 4 for the MEDAS-14 score [hazard ratio (HR): 0.76 (95% confidence interval (CI): 0.62-0.94)] and the RFS score [HR: 0.82 (95% CI: 0.69-0.96)] and as well as in quartile 2 in the HDI score [HR: 0.80 (95% CI: 0.70-0.91)].Conclusion: MEDAS-14, RFS and HDI scores were the strongest diet score predictors of severe NAFLD. A healthy diet might protect against NAFLD development irrespective of the specific approach used to assess diet. However, following these score recommendations could represent optimal dietary approaches to mitigate NAFLD risk. C1 [Petermann-Rocha, Fanny; Carrasco-Marin, Fernanda; Boonpor, Jirapitcha; Parra-Soto, Solange; Phillips, Nathan; Jain, Mahek; Celis-Morales, Carlos] Univ Glasgow, Sch Cardiovasc & Metab Hlth, Glasgow, Scotland. [Petermann-Rocha, Fanny] Univ Diego Portales, Fac Med, Ctr Invest Biomed, Santiago, Chile. [Carrasco-Marin, Fernanda] Univ Concepcion, Ctr Vida Saludable, Concepcion, Chile. [Boonpor, Jirapitcha] Kasetsart Univ, Fac Publ Hlth, Chalermphrakiat Sakon Nakhon Prov Campus, Sakon Nakhon, Thailand. [Parra-Soto, Solange] Univ Bio Bio, Dept Nutr & Publ Hlth, Chillan, Chile. [Shannon, Oliver; Malcomson, Fiona; Mathers, John C.] Newcastle Univ, Populat Hlth Sci Inst, Human Nutr & Exercise Res Ctr, Ctr Healthier Lives, Newcastle Upon Tyne, Tyne & Wear, England. [Deo, Salil; Ho, Frederick K.; Pell, Jill P.] Univ Glasgow, Sch Hlth & Wellbeing, Glasgow, Scotland. [Deo, Salil] Louis Stokes Cleveland VA Med Ctr, Surg Serv, Cleveland, OH USA. [Deo, Salil] Case Western Reserve Univ, Case Sch Med, Cleveland, OH USA. [Livingstone, Katherine M.; Dingle, Sara E.] Deakin Univ, Inst Phys Act & Nutr, Sch Exercise & Nutr Sci, Geelong, Vic, Australia. [Forrest, Ewan] Univ Glasgow, Glasgow Royal Infirm, Dept Gastroenterol, Glasgow, Scotland. [Celis-Morales, Carlos] Univ Catolica Maule, Educ Phys Act & Hlth Res Unit, Human Performance Lab, Talca, Chile. C3 University of Glasgow; University Diego Portales; Universidad de Concepcion; Kasetsart University; Universidad del Bio-Bio; Newcastle University - UK; University of Glasgow; University System of Ohio; Case Western Reserve University; US Department of Veterans Affairs; Veterans Health Administration (VHA); Louis Stokes Cleveland Veterans Affairs Medical Center; University System of Ohio; Case Western Reserve University; Deakin University; University of Glasgow; Universidad Catolica del Maule RP Celis-Morales, C (通讯作者)，Univ Glasgow, Sch Cardiovasc & Metab Hlth, Glasgow, Scotland. EM carlos.celis@glasgow.ac.uk RI ; Livingstone, Katherine/AAA-5123-2021; Malcomson, Fiona/KMY-7212-2024; Boonpor, Jirapitcha/AAV-6485-2021; DEO, SALIL/AHE-2796-2022; Petermann Rocha, Fanny/AAK-1230-2021; Carrasco-Marín, Fernanda/IUQ-0579-2023; Dingle, Sara/OAJ-3647-2025; Parra-Soto, Solange/HIK-1279-2022 OI Forrest, Ewan/0000-0002-7293-2574; Shannon, Oliver/0000-0001-8208-6837; Jain, Mahek/0009-0001-0108-2568; DEO, SALIL/0000-0002-4729-1461; Petermann Rocha, Fanny/0000-0002-4384-4962; Carrasco-Marín, Fernanda/0000-0002-4836-3519; FU Welsh Assembly Government and the British Heart Foundation FX This research has been conducted using the UK biobank resource. We are grateful to UK Biobank participants. 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Metab. PD MAR PY 2024 VL 26 IS 3 BP 860 EP 870 DI 10.1111/dom.15378 EA NOV 2023 PG 11 WC Endocrinology & Metabolism WE Science Citation Index Expanded (SCI-EXPANDED) SC Endocrinology & Metabolism GA HI0O7 UT WOS:001109071400001 PM 37997550 OA Green Submitted, hybrid DA 2026-02-02 ER PT J AU Aller, R Burgueño, B Sigüenza, R Fernández-Rodríguez, C Fernández, N Antolin, B Durà, M Pina, M Lorenzo, S García, C de Luis, DA AF Aller, Rocio Burgueno, Beatriz Siguenza, Rebeca Fernandez-Rodriguez, Conrado Fernandez, Natalia Antolin, Beatriz Dura, Miguel Pina, Maria Lorenzo, Sara Garcia, Concepcion de Luis, Daniel A. TI Comparative study of overweight and obese patients with nonalcoholic fatty liver disease SO REVISTA ESPANOLA DE ENFERMEDADES DIGESTIVAS LA English DT Article DE Steatosis; Overweight; Non-alcoholic fatty liver disease ID NECROSIS-FACTOR-ALPHA; MEDITERRANEAN DIET; INSULIN-RESISTANCE; HEPATIC STEATOSIS; LEPTIN; ASSOCIATION; ADIPONECTIN; PREVALENCE; SEVERITY; NAFLD AB Background and aims: non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disorder in the western world. Although NAFLD prevalence is higher in patients with a BMI > 25 kg/m(2), it is unclear if there are differences between overweight and obese patients. The associated biochemical, dietary and genetic parameters were compared between overweight and obese patients with NAFLD. Methods: patients with biopsy-proven NAFLD (n = 203) were enrolled in a cross-sectional study. The MEDAS questionnaire was used to assess adherence to the Mediterranean diet. Biochemical, anthropometrical parameters and the I148M variant (rs738409) of the PNPLA3 gene and rs180069 of the TNF-alpha gene were evaluated. Results: overweight patients had higher serum adiponectin levels (22.5 +/- 21.9 vs 11.2 +/- 18.1 ng/ml; p < 0.05) and lower resistin (3.3 +/- 1.7 vs 8.1 +/- 8 ng/ml; p < 0.001) and leptin concentrations (22.9 +/- 21.9 vs 55.8 +/- 45 ng/ml; p < 0.001) than obese patients. Non-alcoholic steatohepatitis (NASH) was more frequent in the obese group (59.3% vs 41.3%; p = 0.02). The multivariate analysis showed adherence to the Mediterranean diet to be an independent protective factor for NASH and liver fibrosis in overweight patients (OR 0.7, 95% CI 0.5-0.8). Conclusions: NASH was more prevalent in obese patients than in overweight subjects. HOMA-IR and adherence to the Mediterranean diet provided protection against fibrosis in overweight patients. Adherence to the Mediterranean diet was the only independent factor associated with NASH in these patients. C1 [Aller, Rocio; Burgueno, Beatriz; Antolin, Beatriz; Dura, Miguel; Lorenzo, Sara; Garcia, Concepcion] Univ Valladolid, Hosp Clin Univ, Dept Gastroenterol, Valladolid, Spain. [Aller, Rocio; Fernandez, Natalia; de Luis, Daniel A.] Univ Valladolid, Endocrinol & Nutr Res Ctr, Med Sch, Hosp Clin Univ, Valladolid, Spain. [Aller, Rocio; Fernandez, Natalia; de Luis, Daniel A.] Univ Valladolid, Hosp Clin Univ, Dept Endocrinol & Nutr, Valladolid, Spain. [Siguenza, Rebeca; Pina, Maria] Hosp Clin Univ, Dept Radiol, Valladolid, Spain. [Fernandez-Rodriguez, Conrado] Fdn Hosp Alcorcon, Madrid, Spain. C3 Universidad de Valladolid; Universidad de Valladolid; Universidad de Valladolid; Universidad de la Laguna; University Hospital of the Canary Islands; Alcorcon Foundation University Hospital RP Aller, R (通讯作者)，Univ Valladolid, Hosp Clin Univ, Dept Gastroenterol, Valladolid, Spain.; Aller, R (通讯作者)，Univ Valladolid, Endocrinol & Nutr Res Ctr, Med Sch, C Los Perales 16, Valladolid 47130, Spain. EM roaller@yahoo.es RI ALLER, ROCIO/JXM-2497-2024; de luis roman, Daniel/HKN-3846-2023 OI DURÁ GIL, MIGUEL/0009-0004-0063-6276; Fernandez Roiguez, Conrado M/0000-0002-1915-2157 CR Aller R, 2015, NUTR HOSP, V32, P2518 Ampuero J, 2015, REV ESP ENFERM DIG, V107, P10 Angulo P, 2004, J HEPATOL, V41, P943, DOI 10.1016/j.jhep.2004.08.020 Anstee QM, 2015, SEMIN LIVER DIS, V35, P270, DOI 10.1055/s-0035-1562947 Bedossa P, 2017, LIVER INT, V37, P85, DOI 10.1111/liv.13301 Browning JD, 2004, HEPATOLOGY, V40, P1387, DOI 10.1002/hep.20466 Chalasani N, 2012, GASTROENTEROLOGY, V142, P1592, DOI 10.1053/j.gastro.2012.04.001 Chitturi S, 2002, HEPATOLOGY, V36, P403, DOI 10.1053/jhep.2002.34738 Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486 Crespo J, 2001, HEPATOLOGY, V34, P1158, DOI 10.1053/jhep.2001.29628 de Luis DA, 2016, NUTR HOSP, V33, P602, DOI 10.20960/nh.267 Dongiovanni P, 2013, CURR PHARM DESIGN, V19, P5219, DOI 10.2174/13816128113199990381 Duart MJD, 2002, CLIN CHEM LAB MED, V40, P1161, DOI 10.1515/CCLM.2002.203 Ekstedt M, 2006, HEPATOLOGY, V44, P865, DOI 10.1002/hep.21327 Fazel Y, 2016, METABOLISM, V65, P1017, DOI 10.1016/j.metabol.2016.01.012 FRIEDEWALD WT, 1972, CLIN CHEM, V18, P499 García-Monzón C, 2015, LIVER INT, V35, P1983, DOI 10.1111/liv.12813 Gatselis NK, 2014, CLIN EXP MED, V14, P121, DOI 10.1007/s10238-012-0227-0 Gomez-de-la-Cuesta S, 2018, REV ESP ENFERM DIG, V110, P292, DOI 10.17235/reed.2018.5118/2017 Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404 Hadizadeh Fatemeh, 2017, World J Gastrointest Pathophysiol, V8, P11, DOI [10.4291/wjgp.v8.i2.11, 10.4291/wjgp.v8.i2.11] Hashiba M, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0076161 Kim D, 2017, CLIN GASTROENTEROL H, V15, P474, DOI 10.1016/j.cgh.2016.08.028 Kontogianni MD, 2014, CLIN NUTR, V33, P678, DOI 10.1016/j.clnu.2013.08.014 Leung JCF, 2017, HEPATOLOGY, V65, P54, DOI 10.1002/hep.28697 Matteoni CA, 1999, GASTROENTEROLOGY, V116, P1413, DOI 10.1016/S0016-5085(99)70506-8 Meier U, 2004, CLIN CHEM, V50, P1511, DOI 10.1373/clinchem.2004.032482 MORIN CL, 1995, J CLIN INVEST, V95, P1684, DOI 10.1172/JCI117844 Pfutzner Andreas, 2003, Clin Lab, V49, P571 Ratziu V, 2010, J HEPATOL, V53, P372, DOI 10.1016/j.jhep.2010.04.008 Shin Kyeong-Cheol, 2007, Korean Journal of Internal Medicine, V22, P249, DOI 10.3904/kjim.2007.22.4.249 Sofi F, 2014, WORLD J GASTROENTERO, V20, P7339, DOI 10.3748/wjg.v20.i23.7339 Stojsavljevic S, 2014, WORLD J GASTROENTERO, V20, P18070, DOI 10.3748/wjg.v20.i48.18070 Suominen P, 2004, CLIN CHEM, V50, P219, DOI 10.1373/clinchem.2003.025833 Tzima N, 2009, NUTR METAB, V6, DOI 10.1186/1743-7075-6-30 Valenti L, 2002, GASTROENTEROLOGY, V122, P274, DOI 10.1053/gast.2002.31065 Wildman RP, 2008, ARCH INTERN MED, V168, P1617, DOI 10.1001/archinte.168.15.1617 Zhang SJ, 2017, MEDICINE, V96, DOI 10.1097/MD.0000000000007041 NR 38 TC 10 Z9 12 U1 0 U2 3 PU ARAN EDICIONES, S A PI MADRID PA CASTELLO, 128, 28006 MADRID, SPAIN SN 1130-0108 EI 2340-4167 J9 REV ESP ENFERM DIG JI Rev. Esp. Enferm. Dig. PY 2019 VL 111 IS 4 BP 256 EP 263 DI 10.17235/reed.2019.5926/2018 PG 8 WC Gastroenterology & Hepatology WE Science Citation Index Expanded (SCI-EXPANDED) SC Gastroenterology & Hepatology GA HR7LR UT WOS:000463336100002 PM 30746959 DA 2026-02-02 ER PT J AU Calabrese, FM Disciglio, V Franco, I Sorino, P Bonfiglio, C Bianco, A Campanella, A Lippolis, T Pesole, PL Polignano, M Vacca, M Caponio, GR Giannelli, G De Angelis, M Osella, AR AF Calabrese, Francesco Maria Disciglio, Vittoria Franco, Isabella Sorino, Paolo Bonfiglio, Caterina Bianco, Antonella Campanella, Angelo Lippolis, Tamara Pesole, Pasqua Letizia Polignano, Maurizio Vacca, Mirco Caponio, Giusy Rita Giannelli, Gianluigi De Angelis, Maria Osella, Alberto Ruben TI A Low Glycemic Index Mediterranean Diet Combined with Aerobic Physical Activity Rearranges the Gut Microbiota Signature in NAFLD Patients SO NUTRIENTS LA English DT Article DE NAFLD; gut microbiota; lifestyle intervention; Mediterranean diet; physical activity ID FATTY LIVER-DISEASE; INSULIN-RESISTANCE; CEREAL FIBER; ACID; PATHOGENESIS; ASSOCIATION; METABOLITES; CONSUMPTION; MANAGEMENT; PROTEIN AB Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease, and its prevalence worldwide is increasing. Several studies support the pathophysiological role of the gut-liver axis, where specific signal pathways are finely tuned by intestinal microbiota both in the onset and progression of NAFLD. In the present study, we investigate the impact of different lifestyle interventions on the gut microbiota composition in 109 NAFLD patients randomly allocated to six lifestyle intervention groups: Low Glycemic Index Mediterranean Diet (LGIMD), aerobic activity program (ATFIS_1), combined activity program (ATFIS_2), LGIMD plus ATFIS_1 or ATFIS2 and Control Diet based on CREA-AN (INRAN). The relative abundances of microbial taxa at all taxonomic levels were explored in all the intervention groups and used to cluster samples based on a statistical approach, relying both on the discriminant analysis of principal components (DAPCs) and on a linear regression model. Our analyses reveal important differences when physical activity and the Mediterranean diet are merged as treatment and allow us to identify the most statistically significant taxa linked with liver protection. These findings agree with the decreased 'controlled attenuation parameter' (CAP) detected in the LGIMD-ATFIS_1 group, measured using FibroScan (R). In conclusion, our study demonstrates the synergistic effect of lifestyle interventions (diet and/or physical activity programs) on the gut microbiota composition in NAFLD patients. C1 [Calabrese, Francesco Maria; Vacca, Mirco; De Angelis, Maria] Univ Bari Aldo Moro, Dept Soil Plant & Food Sci, I-70126 Bari, Italy. [Disciglio, Vittoria; Franco, Isabella; Sorino, Paolo; Bonfiglio, Caterina; Bianco, Antonella; Campanella, Angelo; Lippolis, Tamara; Pesole, Pasqua Letizia; Polignano, Maurizio; Caponio, Giusy Rita; Giannelli, Gianluigi; Osella, Alberto Ruben] S de Bellis Res Hosp, Natl Inst Gastroenterol, I-70013 Bari, Italy. C3 Universita degli Studi di Bari Aldo Moro RP Calabrese, FM (通讯作者)，Univ Bari Aldo Moro, Dept Soil Plant & Food Sci, I-70126 Bari, Italy.; Osella, AR (通讯作者)，S de Bellis Res Hosp, Natl Inst Gastroenterol, I-70013 Bari, Italy. EM francesco.calabrese@uniba.it; vittoria.disciglio@irccsdebellis.it; isabella.franco@irccsdebellis.it; paolo.sorino@irccsdebellis.it; catia.bonfiglio@irccsdebellis.it; antonella.bianco@irccsdebellis.it; angelo.campanella@irccsdebellis.it; tamara.lippolis@irccsdebellis.it; letizia.pesole@irccsdebellis.it; maurizio.polignano@irccsdebellis.it; mirco.vacca@uniba.it; giusy.caponio@irccsdebellis.it; gianluigi.giannelli@irccsdebellis.it; maria.deangelis@uniba.it; arosella@irccsdebellis.it RI giannelli, gianluigi/A-8169-2012; Vacca, Mirco/AAU-6490-2021; Sorino, Paolo/JFS-3040-2023; Osella, Alberto/M-6888-2014; Calabrese, Francesco Maria/HLH-5706-2023; Caponio, Giusy Rita/AAA-3053-2021; DISCIGLIO, VITTORIA/K-3376-2018 OI Vacca, Mirco/0000-0003-0813-169X; FRANCO, ISABELLA/0000-0002-3697-0127; Sorino, Paolo/0000-0002-9081-2648; Osella, Alberto/0000-0003-4232-8760; De Angelis, Maria/0000-0002-2010-884X; Polignano, Maurizio Gaetano/0009-0007-5580-2739; Calabrese, Francesco Maria/0000-0003-0176-7046; Campanella, Angelo/0000-0002-5044-4625; Bonfiglio, Caterina/0000-0002-8650-348X; pesole, pasqua letizia/0000-0003-4675-2075; Lippolis, Tamara/0000-0001-8983-0331; Caponio, Giusy Rita/0000-0001-5446-5776; FU Apulia Region [1159]; [748] FX The study was supported by The Italian Minister of Health RC 2019 D.D.G. n. 748 11 October 2018 and by Apulia Region-D.G.R. n. 1159, 28 June 2018 and 2019. 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Beasley, Jeannette M. Aebersold, Karin Jhangiani, Sunil S. Wylie-Rosett, Judith TI Nutritional Management of Insulin Resistance in Nonalcoholic Fatty Liver Disease (NAFLD) SO NUTRIENTS LA English DT Review DE nonalcoholic fatty liver disease; nonalcoholic steatohepatitis; hepatic steatosis; insulin resistance; diabetes; nutrition; macronutrients; review ID KETOGENIC MEDITERRANEAN DIET; LIFE-STYLE INTERVENTION; LOW-CARBOHYDRATE DIET; VITAMIN-E TREATMENT; METABOLIC SYNDROME; CARDIOVASCULAR-DISEASE; HEPATIC STEATOSIS; AMINOTRANSFERASE LEVELS; GLYCEMIC CONTROL; HIGH-PROTEIN AB Nonalcoholic fatty liver disease (NAFLD) is an emerging global health concern. It is the most common form of chronic liver disease in Western countries, affecting both adults and children. NAFLD encompasses a broad spectrum of fatty liver disease, ranging from simple steatosis (NAFL) to nonalcoholic steatohepatitis (NASH), and is strongly associated with obesity, insulin resistance, and dyslipidemia. First-line therapy for NAFLD includes weight loss achieved through diet and physical activity. However, there is a lack of evidenced-based dietary recommendations. The American Diabetes Association's (ADA) recommendations that aim to reduce the risk of diabetes and cardiovascular disease may also be applicable to the NAFLD population. The objectives of this review are to: (1) provide an overview of NAFLD in the context of insulin resistance, and (2) provide a rationale for applying relevant aspects of the ADA recommendations to the nutritional management of NAFLD. C1 [Conlon, Beth A.; Beasley, Jeannette M.; Aebersold, Karin; Wylie-Rosett, Judith] Albert Einstein Coll Med, Dept Epidemiol & Populat Hlth, Bronx, NY 10461 USA. [Jhangiani, Sunil S.] Montefiore Med Ctr Wakefield, Div Gastroenterol & Clin Nutr, Dept Internal Med, Bronx, NY 10469 USA. 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TI Mediterranean Diet and NAFLD: What We Know and Questions That Still Need to Be Answered SO NUTRIENTS LA English DT Review DE nonalcoholic steatohepatitis; chronic liver disease; lifestyle intervention; diet; outcome ID FATTY LIVER-DISEASE; METABOLIC SYNDROME; NONALCOHOLIC STEATOHEPATITIS; CARDIOVASCULAR-DISEASE; LIFE-STYLE; OLIVE OIL; INSULIN-RESISTANCE; CLINICAL CHARACTERISTICS; ALCOHOL-CONSUMPTION; HEPATIC STEATOSIS AB Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of metabolic syndrome and is expected to become the leading cause of end-stage liver disease worldwide over the next few decades. In fact, NAFLD encompasses different clinical scenarios, from the simple accumulation of fat (steatosis) to steatohepatitis (NASH), NASH-cirrhosis, and cirrhosis complications. In this context, it is fundamental to pursue strategies aimed at both preventing the disease and reducing the progression of liver fibrosis once liver damage is already initiated. As of today, no pharmacological treatment has been approved for NAFLD/NASH, and the only recommended treatment of proven efficacy are life-style modifications, including diet and physical exercise pointing at weight loss of 5%-7%. Different dietetic approaches have been proposed in this setting, and in this review, we will discuss the evidence regarding the efficacy of the Mediterranean Diet as a treatment for NAFLD. In particular, we will report the effects on liver-related outcomes. C1 [Torres, Maria Corina Plaz; Bodini, Giorgia; Furnari, Manuele; Marabotto, Elisa; Giannini, Edoardo G.] Univ Genoa, Dipartimento Med Interna, Cattedra Gastroenterol, I-16132 Genoa, Italy. [Torres, Maria Corina Plaz; Bodini, Giorgia; Giannini, Edoardo G.] IRCCS Osped Policlin San Martino, Programma Dipartimentale Diag & Terapia Malattie, I-16132 Genoa, Italy. [Torres, Maria Corina Plaz; Aghemo, Alessio; Lleo, Ana; Bodini, Giorgia] Humanitas Clin & Res Ctr IRCCS, Div Med Interna & Epatol, I-20089 Rozzano, Italy. [Aghemo, Alessio; Lleo, Ana] Humanitas Univ, Dipartimento Sci Biomed, I-20090 Pieve Emanuele, Italy. [Miele, Luca] Univ Cattolica Sacro Cuore, Fdn Policlin Gemelli IRCCS, Area Med Interna Gastroenterol & Med Interna, I-20123 Rome, Italy. [Giannini, Edoardo G.] Univ Genoa, Dept Internal Med, Gastroenterol Unit, Viale Benedetto XV 6, I-16132 Genoa, Italy. C3 University of Genoa; University of Genoa; IRCCS AOU San Martino IST; Humanitas University; Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli; University of Genoa RP Giannini, EG (通讯作者)，Univ Genoa, Dipartimento Med Interna, Cattedra Gastroenterol, I-16132 Genoa, Italy.; Giannini, EG (通讯作者)，IRCCS Osped Policlin San Martino, Programma Dipartimentale Diag & Terapia Malattie, I-16132 Genoa, Italy.; Giannini, EG (通讯作者)，Univ Genoa, Dept Internal Med, Gastroenterol Unit, Viale Benedetto XV 6, I-16132 Genoa, Italy. EM egiannini@unige.it RI Bodini, Giorgia/AAC-2888-2019; LLEO, Ana/AAA-5759-2019; Aghemo, Alessio/ABE-5976-2021; Miele, Luca/C-2255-2015; Giannini, Edoardo/E-1120-2012; Torres, Maria/JBI-9165-2023; Marabotto, Elisa/AAB-2874-2021 OI Bodini, Giorgia/0000-0002-8367-0338; LLEO, Ana/0000-0002-0561-7902; Aghemo, Alessio/0000-0003-0941-3226; Miele, Luca/0000-0003-3464-0068; Giannini, Edoardo/0000-0001-8526-837X; FU "Fondi di Ricerca di Ateneo" dell'Universita degli Studi di Genova FX This study was partially supported by the "Fondi di Ricerca di Ateneo" dell'Universita degli Studi di Genova. 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Bonfiglio, C Campanella, A Mirizzi, A Fucilli, F Di Giovanni, G Giampaolo, N Pesole, PL Osella, AR AF Bianco, Antonella Franco, Isabella Curci, Ritanna Bonfiglio, Caterina Campanella, Angelo Mirizzi, Antonella Fucilli, Fabio Di Giovanni, Giuseppe Giampaolo, Nicola Pesole, Pasqua Letizia Osella, Alberto Ruben TI Diet and Exercise Exert a Differential Effect on Glucose Metabolism Markers According to the Degree of NAFLD Severity SO NUTRIENTS LA English DT Article DE exercise; Mediterranean diet; non-alcoholic fatty liver disease; glycosylated hemoglobin; insulin resistance ID FATTY LIVER-DISEASE; MEDITERRANEAN DIET; INSULIN-RESISTANCE; PHYSICAL-ACTIVITY; WEIGHT; RISK; INTERVENTIONS; QUESTIONNAIRE; METAANALYSIS; GLYCOGEN AB Background: Non-Alcoholic Fatty Liver Disease (NAFLD) and Type 2 Diabetes (T2D) are highly prevalent diseases worldwide. Insulin Resistance (IR) is the common denominator of the two conditions even if the precise timing of onset is unknown. Lifestyle change remains the most effective treatment to manage NAFLD. This study aimed to estimate the effect of the Low Glycemic Index Mediterranean Diet (LGIMD) and exercise (aerobic and resistance) over a one-year period on the longitudinal trajectories of glucose metabolism regulatory pathways. Materials and Methods: In this observational study, 58 subjects (aged 18-65) with different degrees of NAFLD severity were enrolled by the National Institute of Gastroenterology-IRCCS "S. de Bellis", to follow a 12-month program of combined exercise and diet. Results: The mean age was 55 +/- 7 years old. Gender was equally distributed among NAFLD categories. There was a statistically significant main effect of time for glycosylated hemoglobin (Hb1Ac) over the whole period ( 5.41, 95% CI: 7.51; 3.32). There was a steady, statistically significant decrease of HbA1c in participants with moderate and severe NAFLD whereas this effect was observed after the 9th month in those with mild NAFLD. Conclusions: The proposed program significantly improves glucose metabolism parameters, especially HbA1c. C1 [Bianco, Antonella; Franco, Isabella; Curci, Ritanna; Bonfiglio, Caterina; Campanella, Angelo; Mirizzi, Antonella; Osella, Alberto Ruben] Natl Inst Gastroenterol IRCCS S Bellis, Lab Epidemiol & Stat, Via Turi, I-70013 Castellana Grotte, BA, Italy. [Fucilli, Fabio; Di Giovanni, Giuseppe; Giampaolo, Nicola] Natl Inst Gastroenterol IRCCS S Bellis, Dept Radiol, I-70013 Castellana Grotte, BA, Italy. [Pesole, Pasqua Letizia] Natl Inst Gastroenterol IRCCS S Bellis, Lab Clin Pathol, I-70013 Castellana Grotte, BA, Italy. RP Osella, AR (通讯作者)，Natl Inst Gastroenterol IRCCS S Bellis, Lab Epidemiol & Stat, Via Turi, I-70013 Castellana Grotte, BA, Italy. EM antonella.bianco@irccsdebellis.it; isabella.franco@irccsdebellis.it; ritanna.curci@irccsdebellis.it; catia.bonfiglio@irccsdebellis.it; angelo.campanella@irccsdebellis.it; dottoressamirizzi@yahoo.com; fabio.fucilli@irccsdebellis.it; giuseppe.digiovanni@irccsdebellis.it; letizia.pesole@irccsdebellis.it; arosella@irccsdebellis.it RI ; Di Giovanni, Giuseppe/N-3047-2013; Osella, Alberto/M-6888-2014 OI Campanella, Angelo/0000-0002-5044-4625; FRANCO, ISABELLA/0000-0002-3697-0127; Bonfiglio, Caterina/0000-0002-8650-348X; pesole, pasqua letizia/0000-0003-4675-2075; Osella, Alberto/0000-0003-4232-8760 FU Ministero della Salute [RC DCS n.864 19/12/2017, 740 10/10/2018] FX This research was funded in full by Ministero della Salute, grant number RC DCS n.864 19/12/2017; RC DDG n. 740 10/10/2018. 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P341, DOI 10.2337/dc17-1590 Wrench E, 2022, ACTA DIABETOL, V59, P1399, DOI 10.1007/s00592-022-01918-8 NR 67 TC 3 Z9 3 U1 2 U2 8 PU MDPI PI BASEL PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND EI 2072-6643 J9 NUTRIENTS JI Nutrients PD MAY 10 PY 2023 VL 15 IS 10 AR 2252 DI 10.3390/nu15102252 PG 15 WC Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Nutrition & Dietetics GA H5VB0 UT WOS:000996626900001 PM 37242135 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Biolato, M Manca, F Marrone, G Cefalo, C Racco, S Miggiano, GA Valenza, V Gasbarrini, A Miele, L Grieco, A AF Biolato, Marco Manca, Fiorella Marrone, Giuseppe Cefalo, Consuelo Racco, Simona Miggiano, Giacinto A. Valenza, Venanzio Gasbarrini, Antonio Miele, Luca Grieco, Antonio TI Intestinal permeability after Mediterranean diet and low-fat diet in non-alcoholic fatty liver disease SO WORLD JOURNAL OF GASTROENTEROLOGY LA English DT Article DE Liver steatosis; Gut-liver axis; Nutrition; Personalized medicine; Visceral obesity ID ALANINE AMINOTRANSFERASE LEVELS; RANDOMIZED CONTROLLED-TRIAL; WEIGHT-LOSS; HEPATIC STEATOSIS; GUT MICROBIOTA; LOW-CARBOHYDRATE; FRUCTOSE; OBESE; RISK; INTERVENTION AB BACKGROUND In non-alcoholic fatty liver disease (NAFLD), a high-fat or high-fructose diet increases intestinal permeability and promotes derangement of the gut-liver axis. We hypothesize that, diet could be able to modulate intestinal permeability in patients with NAFLD. AIM To detect diet-induced modification of intestinal permeability in patients with NAFLD undergoing a Mediterranean diet or a low-fat diet. METHODS The current study was a dietary intervention for non-diabetic, patients with biopsy-verified NAFLD and increased transaminases. A crossover design was employed: participants underwent 16 weeks of Mediterranean diet, 16 wk of free wash-out, and 16 weeks of low-fat diet. Both diets were hypocaloric and no consumption of supplements was allowed. All patients were followed bimonthly by a dietitian. Evaluations of clinical and metabolic parameters were completed at baseline and at the end of each dietary period. Intestinal permeability was assessed by chromium-51 ethylene diamine tetraacetate excretion testing (51Cr-EDTA). RESULTS Twenty Caucasian patients, 90% male, median age 43 years, body mass index (BMI) 30.9, with biopsy-verified NAFLD were enrolled. At the end of 16 weeks of a Mediterranean diet, a significant reduction in mean body weight (-5.3 +/- 4.1 kg, P = 0.003), mean waist circumference (-7.9 +/- 4.9 cm, P = 0.001), and mean transaminase levels [alanine aminotransferase (ALT) -28.3 +/- 11.9 IU/L, P = 0.0001; aspartate. aminotransferase (AST) -6.4 +/- 56.3 IU/L, P = 0.01] were observed. These benefits were maintained after 16 wk of wash-out and also after 16 wk of low-fat diet, without further improvements. Fourteen of the 20 patients had intestinal permeability alteration at baseline (mean percentage retention of 51Cr-EDTA = 5.4%), but no significant changes in intestinal permeability were observed at the end of the 16 wk of the Mediterranean diet or 16 wk of the low-fat diet. CONCLUSION Mediterranean diet is an effective strategy for treating overweight, visceral obesity and serum transaminase in patients with NAFLD. If the Mediterranean diet can improve intestinal permeability in patients with NAFLD, it deserves further investigation. C1 [Biolato, Marco; Marrone, Giuseppe; Racco, Simona; Miggiano, Giacinto A.; Gasbarrini, Antonio; Miele, Luca; Grieco, Antonio] Fdn Policlin Univ A Gemelli IRCCS, Dept Gastroenterol Endocrine Metab & Nefrourol Sc, I-00168 Rome, Italy. [Manca, Fiorella; Miggiano, Giacinto A.; Gasbarrini, Antonio; Miele, Luca] Univ Cattolica Sacro Cuore, Inst Special Med Pathol & Med Semeiot, I-00168 Rome, Italy. [Cefalo, Consuelo; Grieco, Antonio] Univ Cattolica Sacro Cuore, Inst Internal Med & Geriatr, I-00168 Rome, Italy. [Valenza, Venanzio] Fdn Policlin Univ A Gemelli IRCCS, Dept Image Diagnost Oncol Radiotherapy & Hematol, I-00168 Rome, Italy. [Valenza, Venanzio] Univ Cattolica Sacro Cuore, Nucl Med Inst, I-00168 Rome, Italy. C3 Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli; Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli; Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli; Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli; Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli RP Biolato, M (通讯作者)，Fdn Policlin Univ A Gemelli IRCCS, Liver Transplant Med, Largo A Gemelli 8, I-00168 Rome, Italy. EM marco.biolato@policlinicogemelli.it RI Gasbarrini, Antonio/AAB-8487-2019; Gasbarrini, Antonio/AAB-8487-2019; Miele, Luca/C-2255-2015; BIOLATO, Marco/AAC-6691-2022; Marrone, Giuseppe/AAK-9105-2020 OI Gasbarrini, Antonio/0000-0003-4863-6924; Gasbarrini, Antonio/0000-0002-6230-1779; Miele, Luca/0000-0003-3464-0068; BIOLATO, Marco/0000-0002-5172-8208; Marrone, Giuseppe/0000-0002-9475-3948 FU Italian Ministry of Education, University and Research (MIUR), scientific research programs of relevant national interest year [2010C4JJWB] FX Supported by the Italian Ministry of Education, University and Research (MIUR), scientific research programs of relevant national interest year 2010-2011, No. 2010C4JJWB. 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Gastroenterol. PD JAN 28 PY 2019 VL 25 IS 4 BP 509 EP 520 DI 10.3748/wjg.v25.i4.509 PG 12 WC Gastroenterology & Hepatology WE Science Citation Index Expanded (SCI-EXPANDED) SC Gastroenterology & Hepatology GA HI8YS UT WOS:000456742500010 PM 30700946 OA Green Submitted, hybrid DA 2026-02-02 ER PT J AU Monserrat-Mesquida, M Quetglas-Llabrés, MM Bouzas, C Pastor, O Ugarriza, L Llompart, I Cevallos-Ibarra, K Sureda, A Tur, JA AF Monserrat-Mesquida, Margalida Quetglas-Llabres, Maria Magdalena Bouzas, Cristina Pastor, Oscar Ugarriza, Lucia Llompart, Isabel Cevallos-Ibarra, Karla Sureda, Antoni Tur, Josep A. TI Plasma Fatty Acid Composition, Oxidative and Inflammatory Status, and Adherence to the Mediterranean Diet of Patients with Non-Alcoholic Fatty Liver Disease SO ANTIOXIDANTS LA English DT Article DE hepatic steatosis; Mediterranean diet; fatty acids; inflammation; ultra-processed foods ID LIFE-STYLE; METABOLIC SYNDROME; INTERVENTION; SUPPLEMENTATION; RATIO AB Non-alcoholic fatty liver disease (NAFLD) is a complex and increasingly prevalent cardiometabolic disorder worldwide. As of today, NAFLD is a pathology without specific pharmacological treatment, with the Mediterranean diet (MedDiet) being the most widely used approach for its management. The objective of this study is to assess the effects of adherence to the Mediterranean diet on fatty acid plasma levels, as well as on the oxidative and inflammatory status of NAFLD patients. A total of 100 adult patients (40-60 years old) diagnosed with NAFLD and from the Balearic Islands, Spain, were classified into three groups according to their adherence to the MedDiet. Consumption was assessed using a validated 143-item semiquantitative Food Frequency Questionnaire. Food items (g/day) were categorised according to their processing using the NOVA system. Anthropometrics, blood pressure, aminotransferases, Dietary Inflammatory Index (DII), inflammatory biomarkers, and fatty acid levels were measured in the plasma of NAFLD patients. High adherence to the MedDiet is associated to a highly plant-based diet, low ultra-processed food (UPF) consumption, low intake of dietary lipids, low intake of animal fats, high intake of monounsaturated fatty acid (MUFA; mainly palmitoleic acid), low intake of saturated fatty acids (SFAs; practically all dietary SFAs), low intake of trans-fatty acids, high intake of omega-3 fatty acids (mainly eicosapentaenoic acid), a higher n-6:n-3 in ratio, low intake of omega-6 fatty acids, and a low level of interleukin-6 (IL-6). High adherence to the MedDiet is related to a better fatty acid profile in the plasma, fewer SFAs and more MUFA and polyunsaturated fatty acids (PUFAs), a plasma biochemical profile, better proinflammatory status, and decreased ultra-processed food consumption of NAFLD patients. C1 [Monserrat-Mesquida, Margalida; Quetglas-Llabres, Maria Magdalena; Bouzas, Cristina; Ugarriza, Lucia; Llompart, Isabel; Sureda, Antoni; Tur, Josep A.] Univ Balear Isl IUNICS, Res Grp Community Nutr & Oxidat Stress, E-07122 Palma De Mallorca, Spain. [Monserrat-Mesquida, Margalida; Quetglas-Llabres, Maria Magdalena; Bouzas, Cristina; Ugarriza, Lucia; Llompart, Isabel; Sureda, Antoni; Tur, Josep A.] Inst Salud Carlos III, CIBEROBN Physiopathol Obes & Nutr, E-28029 Madrid, Spain. [Monserrat-Mesquida, Margalida; Quetglas-Llabres, Maria Magdalena; Bouzas, Cristina; Ugarriza, Lucia; Llompart, Isabel; Sureda, Antoni; Tur, Josep A.] Hlth Res Inst Balear Isl IdISBa, E-07120 Palma De Mallorca, Spain. [Pastor, Oscar; Cevallos-Ibarra, Karla] Hosp Univ Ramon y Cajal IRYCIS, Serv Clin Biochem, E-28023 Madrid, Spain. [Ugarriza, Lucia] IBSalut, CS Camp Redo, E-07010 Palma De Mallorca, Spain. [Llompart, Isabel] Univ Hosp Son Espases, Clin Anal Serv, E-07198 Palma De Mallorca, Spain. C3 Instituto de Salud Carlos III; CIBER - Centro de Investigacion Biomedica en Red; CIBEROBN; Institut Investigacio Sanitaria Illes Balears (IdISBa); Hospital Universitario Ramon y Cajal; Hospital Universitari Son Espases RP Tur, JA (通讯作者)，Univ Balear Isl IUNICS, Res Grp Community Nutr & Oxidat Stress, E-07122 Palma De Mallorca, Spain.; Tur, JA (通讯作者)，Inst Salud Carlos III, CIBEROBN Physiopathol Obes & Nutr, E-28029 Madrid, Spain.; Tur, JA (通讯作者)，Hlth Res Inst Balear Isl IdISBa, E-07120 Palma De Mallorca, Spain. EM karla.cevallos@crc.es; pep.tur@uib.es RI ; Quetglas Llabrés, Maria Magdalena/AAA-4412-2019; Monserrat Mesquida, Margalida/AAB-4773-2019; Tur, Josep/AAE-5748-2020; Sureda, Antoni/N-9588-2019; PASTOR, OSCAR/HSD-6372-2023; Bouzas, Cristina/AAE-2069-2019 OI , Antoni/0000-0001-8656-6838; Quetglas Llabrés, Maria Magdalena/0000-0003-4155-7780; Monserrat Mesquida, Margalida/0000-0002-8856-135X; Tur, Josep/0000-0002-6940-0761; PASTOR, OSCAR/0000-0002-4368-433X; FU The authors especially thank the participants for their enthusiastic collaboration and the personnel for their outstanding support and exceptional efforts. CIBEROBN is an initiative of Instituto de Salud Carlos III, Spain.; CIBEROBN is an initiative of Instituto de Salud Carlos III, Spain FX The authors especially thank the participants for their enthusiastic collaboration and the personnel for their outstanding support and exceptional efforts. CIBEROBN is an initiative of Instituto de Salud Carlos III, Spain. 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ANTIOXIDANTS-BASEL JI Antioxidants PD AUG PY 2023 VL 12 IS 8 AR 1554 DI 10.3390/antiox12081554 PG 15 WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science & Technology WE Science Citation Index Expanded (SCI-EXPANDED) SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science & Technology GA Q2ZZ3 UT WOS:001056261000001 PM 37627549 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Lago-Sampedro, A Oualla-Bachiri, W García-Serrano, S Maldonado-Araque, C Valdés, S Doulatram-Gamgaram, V Olveira, G Delgado, E Chaves, FJ Castaño, L Calle-Pascual, A Franch-Nadal, J Rojo-Martínez, G García-Escobar, E AF Lago-Sampedro, Ana Oualla-Bachiri, Wasima Garcia-Serrano, Sara Maldonado-Araque, Cristina Valdes, Sergio Doulatram-Gamgaram, Viyey Olveira, Gabriel Delgado, Elias Chaves, Felipe Javier Castano, Luis Calle-Pascual, Alfonso Franch-Nadal, Josep Rojo-Martinez, Gemma Garcia-Escobar, Eva TI Protective Effect of High Adherence to Mediterranean Diet on the Risk of Incident Type-2 Diabetes in Subjects with MAFLD: The Di@bet.es Study SO NUTRIENTS LA English DT Article DE Mediterranean diet; protecting factor; Type-2 diabetes incidence; MAFLD ID FATTY LIVER-DISEASE; INSULIN-RESISTANCE; ASSOCIATION; POPULATION; PREVALENCE; MANAGEMENT AB Background/Objectives: Metabolic Dysfunction-Associated Fatty Liver Disease (MAFLD) increases the risk of Type-2 Diabetes (T2DM). The Mediterranean diet (MD) has shown advantages in the management of MAFLD and preventing co-morbidities; however, its relationship with T2DM development in MAFLD has been less investigated. We aimed to evaluate the association of MD adherence with the risk of incident T2DM in the Spanish adult population with MAFLD and according to their weight gain at 7.5 years follow-up. Methods: A cohort of 714 participants (without weight increment: 377; with weight increment: 337) from the Di@bet.es cohort study with MAFLD and without T2DM at baseline were investigated. Anthropometric, sociodemographic, clinical data, and a survey on habits were recorded. OGTT and fasting blood biochemistry determinations were made. Baseline adherence to MD was estimated by the adapted 14-point MEDAS questionnaire and categorized as high and low adherence. Results: In total, 98 people developed T2DM at follow-up. The high adherence to MD was inversely associated with the development of T2DM in both the overall population (0.52 [0.31-0.87]) and subjects without weight gain at follow-up (0.35 [0.16-0.78]). Conclusions: Our results suggest the protective effect of high adherence to MD regarding the risk of T2DM in subjects with MAFLD, with this health benefit being more evident in men with the absence of weight gain. These results support the recommendations for MD use in these patients. C1 [Lago-Sampedro, Ana; Oualla-Bachiri, Wasima; Garcia-Serrano, Sara; Maldonado-Araque, Cristina; Valdes, Sergio; Doulatram-Gamgaram, Viyey; Olveira, Gabriel; Chaves, Felipe Javier; Castano, Luis; Calle-Pascual, Alfonso; Franch-Nadal, Josep; Rojo-Martinez, Gemma; Garcia-Escobar, Eva] Inst Salud Carlos III, Ctr Investigacionn Biomed Red Diabet & Enfermedade, Madrid 28029, Spain. [Lago-Sampedro, Ana; Oualla-Bachiri, Wasima; Garcia-Serrano, Sara; Maldonado-Araque, Cristina; Valdes, Sergio; Doulatram-Gamgaram, Viyey; Olveira, Gabriel; Rojo-Martinez, Gemma; Garcia-Escobar, Eva] Hosp Reg Univ Malaga, UGC Endocrinol & Nutr, IBIMA Plataforma BIONAND, Malaga 29009, Spain. [Lago-Sampedro, Ana; Oualla-Bachiri, Wasima; Doulatram-Gamgaram, Viyey] Univ Malaga, Dept Med & Dermatol, UMA, Malaga 29071, Spain. [Delgado, Elias; Castano, Luis] Inst Salud Carlos III, Ctr Investigac Biomed Red Enfermedades Raras CIBER, Madrid 28029, Spain. [Delgado, Elias] Univ Oviedo, Cent Univ Hosp Asturias, Hlth Res Inst Principal Asturias ISPA, Dept Endocrinol & Nutr, Oviedo 33011, Spain. [Chaves, Felipe Javier] INCLIVA Biomed Res Inst, Genom & Genet Diag Unit, Valencia 46010, Spain. [Castano, Luis] Univ Basque Country, Hosp Univ Cruces, Biobizkaia Hlth Res Inst, CIBERDEM,CIBERER,Endo ERN, Baracaldo 48903, Spain. [Calle-Pascual, Alfonso] San Carlos Univ Hosp, Dept Endocrinol & Nutr, E-28040 Madrid, Spain. [Franch-Nadal, Josep] IDIAP Jordi Gol Fdn, Catalan Inst Hlth, Res Support Unit, EAP Raval Sud,GEDAPS Network,Primary Care Res Supp, Barcelona 08001, Spain. C3 Instituto de Salud Carlos III; Universidad de Malaga; Instituto de Salud Carlos III; Central University Hospital Asturias; Instituto de Investigacion Sanitaria del Principado de Asturias (ISPA); University of Oviedo; Hospital Universitario Cruces; University of Basque Country; CIBER - Centro de Investigacion Biomedica en Red; CIBERER; CIBERDEM; Hospital Clinico San Carlos; Institut Catala de la Salut (ICS) RP Rojo-Martínez, G; García-Escobar, E (通讯作者)，Inst Salud Carlos III, Ctr Investigacionn Biomed Red Diabet & Enfermedade, Madrid 28029, Spain.; Rojo-Martínez, G; García-Escobar, E (通讯作者)，Hosp Reg Univ Malaga, UGC Endocrinol & Nutr, IBIMA Plataforma BIONAND, Malaga 29009, Spain. EM eliasdelga@gmail.com; felipe.chaves@uv.es; acallepascual@hotmail.com; josep.franch@gmail.com; gemma.rojo.m@gmail.com; eyring@gmail.com RI ; Franch-Nadal, Josep/AAC-1945-2019; Doulatram, Viyey/AAF-1375-2021; CHAVES, FELIPE J/ABC-3294-2021; Calle-Pascual, Alfonso L/ABH-2607-2022; Rojo-Martínez, Gemma/HRD-0592-2023; Delgado, Elias/B-2634-2013; OLVEIRA, GABRIEL/K-8778-2012 OI GARCIA-ESCOBAR, EVA/0000-0002-0134-3473; Franch-Nadal, Josep/0000-0002-5175-1555; Valdés, Sergio/0000-0001-8623-4331; Oualla Bachiri, Wasima/0000-0002-9760-0883; Maldonado-Araque, Cristina/0000-0002-3452-3489; CHAVES, FELIPE J/0000-0001-8009-3689; Calle-Pascual, Alfonso L/0000-0002-3628-9323; Lago-Sampeo, Ana M/0000-0002-3072-9981; Rojo-Martínez, Gemma/0000-0003-2179-2134; Delgado, Elias/0000-0001-6114-9712; OLVEIRA, GABRIEL/0000-0002-7646-2899 FU CIBERDEM (Ministerio de Economia, Industria y Competitividad-ISCIII); Ministerio de Sanidad, Servicios Sociales e Igualdad-ISCIII, Instituto de Salud Carlos III [PI23/00347, PI20/01322, PI18/01165, PI17/02136, PI14/00710, PI14/01104, PI14/00970, PI14/00874, PIE14/00031]; European Regional Development Fund (ERDF) "A way to build Europe"; Consejeria de Salud [C-0060-2012]; Instituto de Salud Carlos III [FI2100040] FX This investigation has been supported by CIBERDEM (Ministerio de Economia, Industria y Competitividad-ISCIII), Ministerio de Sanidad, Servicios Sociales e Igualdad-ISCIII, Instituto de Salud Carlos III (research grants PI23/00347, PI20/01322, PI18/01165, PI17/02136, PI14/00710, PI14/01104, PI14/00970, PI14/00874, PIE14/00031) and cofunding by the European Regional Development Fund (ERDF) "A way to build Europe". LifeScan Espana (Madrid, Spain) kindly donated glucometers and test strips for capillary glucose measurements. Gemma Rojo-Martinez belongs to the Nicolas Monardes research program of the Consejeria de Salud (C-0060-2012; Junta de Andalucia, Spain). WOF is recipient of a "PFIS" predoctoral resear contract (FI2100040, Instituto de Salud Carlos III). 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A. TI You Are What You Eat: A Review on Dietary Interventions for Treating Pediatric Nonalcoholic Fatty Liver Disease SO NUTRIENTS LA English DT Review DE pediatric nonalcoholic fatty liver; dietary interventions; nutrition ID LIFE-STYLE INTERVENTION; HYPERTENSION DASH DIET; OBESE CHILDREN; DOCOSAHEXAENOIC ACID; MEDITERRANEAN DIET; BODY-COMPOSITION; CLINICAL-TRIAL; RISK-FACTORS; VITAMIN-E; FRUCTOSE AB As the obesity pandemic worsens, cases of pediatric nonalcoholic fatty liver disease (NAFLD) and complications of this disease, such as progressive liver failure, in young adults will continue to rise. Lifestyle changes in the form of dietary modifications and exercise are currently first-line treatments. Large pediatric-specific randomized controlled trials to support specific interventions are currently lacking. A variety of dietary modifications in children with NAFLD have been suggested and studied with mixed results, including low-sugar and high-protein diets, the Mediterranean diet, and the Dietary Approach to Stop Hypertension (DASH). The roles of dietary supplements such as Vitamin E, polyunsaturated fatty acids (PUFAs), ginger, and probiotics have also been investigated. A further understanding of specific dietary interventions and supplements is needed to provide both generalizable and sustainable dietary recommendations to reverse the progression of NAFLD in the pediatric population. C1 [Sandel, Piper; Ma, Lawrence; Wang, Helen] Univ Calif San Diego, Dept Pediat, Sect Acad Gen Pediat, San Diego, CA 92123 USA. [Pasman, Eric A. A.] Naval Med Ctr San Diego, Dept Pediat, Div Pediat Gastroenterol, San Diego, CA 92134 USA. [Pasman, Eric A. A.] Uniformed Serv Univ Hlth Sci, Dept Pediat, Bethesda, MD 20814 USA. C3 University of California System; University of California San Diego; United States Department of Defense; United States Navy; Naval Medical Center San Diego; Uniformed Services University of the Health Sciences - USA RP Sandel, P (通讯作者)，Univ Calif San Diego, Dept Pediat, Sect Acad Gen Pediat, San Diego, CA 92123 USA. 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Expanded (SCI-EXPANDED) SC Nutrition & Dietetics GA O7MX2 UT WOS:001045618300001 PM 37571287 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Bagnato, CB Bianco, A Bonfiglio, C Franco, I Verrelli, N Carella, N Shahini, E Zappimbulso, M Giannuzzi, V Pesole, PL Ancona, A Giannelli, G AF Bagnato, Claudia Beatrice Bianco, Antonella Bonfiglio, Caterina Franco, Isabella Verrelli, Nicola Carella, Nicola Shahini, Endrit Zappimbulso, Marianna Giannuzzi, Vito Pesole, Pasqua Letizia Ancona, Anna Giannelli, Gianluigi TI Healthy Lifestyle Changes Improve Cortisol Levels and Liver Steatosis in MASLD Patients: Results from a Randomized Clinical Trial SO NUTRIENTS LA English DT Article DE exercise; Mediterranean diet; hepatic steatosis; steatotic liver disease associated with metabolic dysfunction ID PHYSICAL-ACTIVITY; EXERCISE; VALIDITY; RELIABILITY; QUESTIONNAIRE AB Background: Steatotic liver disease associated with metabolic dysfunction (MASLD) affects up to about 30% of the general adult population and is closely related to obesity and the metabolic syndrome. Cortisol, a stress-related hormone contributing to hepatic fat accumulation and insulin resistance, also promotes progression of the disease. The study aims to investigate the impact of lifestyle modifications on cortisol levels and hepatic steatosis in patients with MASLD. Methods: In a 16-week three-arm randomized trial, 42 patients were randomly assigned to three groups who received dietary advice (CG), dietary advice combined with aerobic exercise (AE + DA), or dietary advice with high-intensity interval training (HIIT + DA). Before the start, after 2 months of intervention, and at the end of the project, medical evaluations, routine biochemical assessments, and psychological questionnaires were analyzed. At baseline and at the end of 4 months, hepatic steatosis was evaluated by Fibroscan (R). Results: In the study population, severe hepatic steatosis (74%) and obesity (98%) were prevalent at the beginning of the study. A statistically significant (p-value = 0.001) reduction in circulating cortisol levels was observed over time in the two groups doing exercise, especially in HIIT + DA (p-value = 0.006). Hepatic steatosis, assessed by Fibroscan (R), disappeared in 10 participants (CAP value < 248, p-value = 0.003). CAP values and waist circumference decreased in all groups, statistically significantly in the AE + DA group (p-value = 0.005; p-value = 0.04, respectively). Conclusions: The study emphasizes the benefits of combining diet and exercise in managing MASLD. HIIT + DA significantly decreased cortisol levels, while AE + DA was the most potent intervention for reducing hepatic steatosis. C1 [Bagnato, Claudia Beatrice; Bianco, Antonella; Franco, Isabella; Verrelli, Nicola] Natl Inst Gastroenterol IRCCS Saverio Bellis, Lab Movement & Wellness, I-70013 Castellana Grotte, BA, Italy. [Bonfiglio, Caterina] Natl Inst Gastroenterol IRCCS Saverio Bellis, Data Sci, I-70013 Castellana Grotte, BA, Italy. [Carella, Nicola] Natl Inst Gastroenterol IRCCS Saverio Bellis, Clin Res Unit, I-70013 Castellana Grotte, BA, Italy. [Shahini, Endrit; Zappimbulso, Marianna; Giannuzzi, Vito] Natl Inst Gastroenterol IRCCS Saverio Bellis, Gastroenterol Unit, I-70013 Castellana Grotte, BA, Italy. [Pesole, Pasqua Letizia; Ancona, Anna] Natl Inst Gastroenterol IRCCS Saverio Bellis, Core Facil Biobank, I-70013 Castellana Grotte, BA, Italy. [Giannelli, Gianluigi] Natl Inst Gastroenterol IRCCS Saverio Bellis, Sci Direct, I-70013 Castellana Grotte, BA, Italy. RP Bianco, A (通讯作者)，Natl Inst Gastroenterol IRCCS Saverio Bellis, Lab Movement & Wellness, I-70013 Castellana Grotte, BA, Italy. EM claudia.bagnato@irccsdebellis.it; antonella.bianco@irccsdebellis.it; catia.bonfiglio@irccsdebellis.it; isabella.franco@irccsdebellis.it; nicola.verrelli@irccsdebellis.it; nicola.carella@irccsdebellis.it; endrit.shahini@irccsdebellis.it; marianna.zappimbulso@irccsdebellis.it; vito.giannuzzi@irccsdebellis.it; letizia.pesole@irccsdebellis.it; anna.ancona@irccsdebellis.it; gianluigi.giannelli@irccsdebellis.it RI ; Shahini, Enit/AAX-7646-2021; Giannelli, Gianluigi/A-8169-2012 OI pesole, pasqua letizia/0000-0003-4675-2075; Shahini, Enit/0000-0002-4909-0436; Giannelli, Gianluigi/0000-0002-5140-8060; bianco, antonella/0000-0001-9319-5422; Bonfiglio, Caterina/0000-0002-8650-348X; FRANCO, ISABELLA/0000-0002-3697-0127; Ancona, Anna/0009-0009-7662-1763 FU the Italian Ministry of Health [RC 2024]; Italian Ministry of Health FX This research was funded by the Italian Ministry of Health RC 2024. 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Vos, Miriam B. TI Carbohydrates and diet patterns in nonalcoholic fatty liver disease in children and adolescents SO CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE LA English DT Review DE carbohydrates; children; dietary patterns; nonalcoholic fatty liver disease; sugar ID DE-NOVO LIPOGENESIS; MEDITERRANEAN DIET; INSULIN-RESISTANCE; PHYSICAL-ACTIVITY; OVERWEIGHT; FRUCTOSE; OBESITY; PNPLA3; RISK; PATHOGENESIS AB Purpose of reviewThe primary treatment for nonalcoholic fatty liver disease (NAFLD) in children is lifestyle change, including a healthier diet. However, there are no agreed upon expert recommendations for a specific diet in the prevention or treatment of NAFLD. In this study, we review studies published between 2015 and 2017 contributing to further understanding of the role of diet in the development and progression of NAFLD, particularly those addressing sugars and dietary patterns.Recent findingsMultiple recent studies have expanded on earlier evidence that suggests that high intake of sugars plays a causal role in the development of NAFLD, including several recent experimental studies in adults and children that support a unique effect of fructose consumption on liver fat accumulation. Evidence also points to protective effects of dietary patterns that include but are not limited to minimizing sugar intake, Dietary Approaches to Stop Hypertension (DASH), high protein and the Mediterranean diet. The effect of diet may act through its impact on the microbiome, and may be modified by presence or absence of genetic polymorphisms (nutrigenomics) and several new studies demonstrate this.SummaryDiet appears to be a powerful tool in the prevention and treatment of NAFLD. It is imperative that researchers and clinicians continue to hone in on the mechanistic pathways and specific diets to reverse the growing morbidity and mortality of NAFLD. C1 [Sekkarie, Ahlia; Welsh, Jean A.; Vos, Miriam B.] Emory Univ, Dept Pediat, Sch Med, Nutr & Hlth Sci Program,Laney Grad Sch, Atlanta, GA 30322 USA. C3 Emory University RP Vos, MB (通讯作者)，1760 Haygood Dr, Atlanta, GA 30322 USA. 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Opin. Clin. Nutr. Metab. Care PD JUL PY 2018 VL 21 IS 4 BP 283 EP 288 DI 10.1097/MCO.0000000000000476 PG 6 WC Endocrinology & Metabolism; Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Endocrinology & Metabolism; Nutrition & Dietetics GA GI3WA UT WOS:000434301500010 PM 29781841 DA 2026-02-02 ER PT J AU Abenavoli, L Milanovic, M Milic, N Luzza, F Giuffrè, AM AF Abenavoli, Ludovico Milanovic, Maja Milic, Natasa Luzza, Francesco Giuffre, Angelo Maria TI Olive oil antioxidants and non-alcoholic fatty liver disease SO EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY LA English DT Review DE Food; Mediterranean diet; metabolism; inflammation; treatment; prevention ID MEDITERRANEAN DIET; PHENOLIC-COMPOUNDS; HEPATIC STEATOSIS; BETA-CAROTENE; LDL OXIDATION; RISK-FACTORS; VIRGIN; ACID; HYDROXYTYROSOL; CONSUMPTION AB Introduction: Non-alcoholic fatty liver disease (NAFLD) is estimated to affect 25% of adult people worldwide. Nowadays, there is no definite treatment for NAFLD. International guidelines define an approach based on lifestyle changes, included a health alimentary regimen. The Mediterranean diet (MD) represents the gold standard in preventive medicine, probably due to the harmonic combination of many elements with antioxidant and anti-inflammatory properties. Its prescription is also recommended in patients with NAFLD. Olive oil, as part of MD, is associated with benefits on human health especially regarding the cardiovascular system, obesity, diabetes and related metabolic disorders. Areas covered: An overview of the beneficial effects of olive oil in the prevention and treatment of NAFLD is given. Expert opinion: A large body of evidence emphasizes that olive oil, used as primary source of fat in MD, may play a crucial role in the health benefits of NAFLD patients. However, there are still scarce clinical data that evaluate the direct effect of olive oil in human with NAFLD. C1 [Abenavoli, Ludovico; Luzza, Francesco] Magna Graecia Univ Catanzaro, Dept Hlth Sci, Viale Europa Germaneto, I-88100 Catanzaro, Italy. [Milanovic, Maja; Milic, Natasa] Univ Novi Sad, Dept Pharm, Fac Med, Novi Sad, Serbia. [Giuffre, Angelo Maria] Univ Mediterranea, Dept Agr, Calabria, Italy. C3 Magna Graecia University of Catanzaro; University of Novi Sad; Universita Mediterranea di Reggio Calabria RP Abenavoli, L (通讯作者)，Magna Graecia Univ Catanzaro, Dept Hlth Sci, Viale Europa Germaneto, I-88100 Catanzaro, Italy. EM l.abenavoli@unicz.it RI Abenavoli, Ludovico/J-4394-2019; Giuffrè, Angelo Maria/S-9548-2019; Milanović, Maja/JXN-5115-2024 OI Milić, Nataša/0000-0002-8595-6065; Milanović, Maja/0000-0003-4082-5480; Luzza, Francesco/0000-0001-5120-1046 FU Distretto ad alta tecnologia agroindustriale della Calabria AGRIFOODTECH [PON03PE_00090_2] FX This research was supported by Distretto ad alta tecnologia agroindustriale della Calabria AGRIFOODTECH - PROGETTO PON03PE_00090_2, Sustainable models and new technologies for olives and olive oil. CR Abenavolf L. 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Gastroenterol. Hepatol. PD AUG 3 PY 2019 VL 13 IS 8 BP 739 EP 749 DI 10.1080/17474124.2019.1634544 EA JUN 2019 PG 11 WC Gastroenterology & Hepatology WE Science Citation Index Expanded (SCI-EXPANDED) SC Gastroenterology & Hepatology GA IO0FA UT WOS:000473220300001 PM 31215262 DA 2026-02-02 ER PT J AU Younossi, ZM Corey, KE Lim, JK AF Younossi, Zobair M. Corey, Kathleen E. Lim, Joseph K. TI AGA Clinical Practice Update on Lifestyle Modification Using Diet and Exercise to Achieve Weight Loss in the Management of Nonalcoholic Fatty Liver Disease: Expert Review SO GASTROENTEROLOGY LA English DT Article DE Fatty Liver; Steatohepatitis; NASH; Weight Loss; Exercise; Diet; Liver Fibrosis; Obesity; Cirrhosis ID MEDITERRANEAN DIET; METABOLIC SYNDROME; FRUCTOSE CONSUMPTION; PHYSICAL-ACTIVITY; RISK; MORTALITY; OBESITY; INTERVENTION; IMPROVEMENTS; PREVALENCE AB Nonalcoholic fatty liver disease (NAFLD) is a leading cause of chronic liver disease, with global public health impact affecting more than 25% of the global population. NAFLD is associated with significant morbidity and mortality from cirrhosis, hepatocellular carcinoma, solid organ malignancies, diabetes mellitus, cardiovascular disease, and obstructive sleep apnea, resulting in significant health care resource use and decreased health-related quality of life. NAFLD cirrhosis is a leading indication for liver transplantation in the United States. Lifestyle modification to achieve weight loss remains a first-line intervention in patients with NAFLD. We summarize evidence-based interventions for lifestyle modification in the treatment of NAFLD and provided best practice advice statements to address key issues in clinical management. C1 [Younossi, Zobair M.] Inova Fairfax Med Campus, Ctr Liver Dis, Falls Church, VA USA. [Younossi, Zobair M.] Inova Fairfax Med Campus, Dept Med, Falls Church, VA USA. [Younossi, Zobair M.] Inova Hlth Syst, Betty & Guy Beatty Ctr Integrated Res, Falls Church, VA USA. [Corey, Kathleen E.] Massachusetts Gen Hosp, Dept Med, Liver Ctr Div Gastroenterol, Boston, MA 02114 USA. [Lim, Joseph K.] Yale Univ, Sch Med, Yale Liver Ctr, New Haven, CT USA. [Lim, Joseph K.] Yale Univ, Sch Med, Sect Digest Dis, New Haven, CT USA. C3 Inova Fairfax Hospital; Inova Fairfax Hospital; Inova Health System; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Yale University; Yale University RP Younossi, ZM (通讯作者)，Betty & Guy Beatty Ctr Integrated Res, Claude Moore Hlth Educ & Res Bldg,3300 Gallows Rd, Falls Church, VA 22042 USA. EM zobair.younossi@inova.org RI Younossi, Zobair M./JRY-9916-2023 CR Abdelmalek MF, 2010, HEPATOLOGY, V51, P1961, DOI 10.1002/hep.23535 Aberg F, 2020, HEPATOLOGY, V71, P835, DOI 10.1002/hep.30864 Acosta A, 2017, CLIN GASTROENTEROL H, V15, P631, DOI 10.1016/j.cgh.2016.10.023 Allen AM, 2019, J HEPATOL, V71, P1229, DOI 10.1016/j.jhep.2019.08.018 Arnett DonnaK., 2019, CIRCULATION, V140, pe596, DOI [10.1016/j.jacc.2019.03.010, DOI 10.1016/j.jacc.2019.03.010, 10.1161/CIR.0000000000000678, 10.1016] Duarte SMB, 2014, NUTR HOSP, V29, P94, DOI 10.3305/nh.2014.29.1.7068 Di Daniele N, 2017, ONCOTARGET, V8, P8947, DOI 10.18632/oncotarget.13553 Drager LF, 2013, J AM COLL CARDIOL, V62, P569, DOI 10.1016/j.jacc.2013.05.045 Drinda S, 2019, NUTRIENTS, V11, DOI 10.3390/nu11112601 Elias MC, 2010, NUTRITION, V26, P1094, DOI 10.1016/j.nut.2009.09.001 Eslamparast T, 2018, LIVER INT, V38, P1706, DOI 10.1111/liv.13876 Golabi P, 2018, MEDICINE, V97, DOI 10.1097/MD.0000000000011518 Golabi P, 2018, MEDICINE, V97, DOI [10.1097/MD.0000000000010214, 10.1097/md.0000000000010214] Golabi P, 2016, WORLD J GASTROENTERO, V22, P6318, DOI 10.3748/wjg.v22.i27.6318 Hagström H, 2018, HEPATOL COMMUN, V2, P48, DOI 10.1002/hep4.1124 Harrison SA, 2003, AM J GASTROENTEROL, V98, P2485, DOI 10.1111/j.1572-0241.2003.08699.x Hashida R, 2017, J HEPATOL, V66, P142, DOI 10.1016/j.jhep.2016.08.023 Haufe S, 2013, DIABETES CARE, V36, P3786, DOI 10.2337/dc13-0102 Johansson HE, 2019, NUTR DIABETES, V9, DOI 10.1038/s41387-019-0100-2 Katsagoni CN, 2018, BRIT J NUTR, V120, P164, DOI [10.1017/S000711451800137X, 10.1017/s000711451800137x] Keating SE, 2012, J HEPATOL, V57, P157, DOI 10.1016/j.jhep.2012.02.023 Kirk E, 2009, GASTROENTEROLOGY, V136, P1552, DOI 10.1053/j.gastro.2009.01.048 Koutoukidis DA, 2019, JAMA INTERN MED, V179, P1303, DOI 10.1001/jamainternmed.2019.4091 Koutoukidis DA, 2019, JAMA INTERN MED, V179, P1262, DOI 10.1001/jamainternmed.2019.2248 Kuhen BJ., 2019, JAMA-J AM MED ASSOC, V322, P2270 Lu FB, 2020, J GASTROEN HEPATOL, V35, P2041, DOI 10.1111/jgh.15156 Ma JT, 2018, GASTROENTEROLOGY, V155, P107, DOI 10.1053/j.gastro.2018.03.038 Mozaffarian D, 2016, CIRCULATION, V133, P187, DOI 10.1161/CIRCULATIONAHA.115.018585 Ong JP, 2008, J HEPATOL, V49, P608, DOI 10.1016/j.jhep.2008.06.018 Ouyang X, 2008, J HEPATOL, V48, P993, DOI 10.1016/j.jhep.2008.02.011 Paik JM, 2019, HEPATOL COMMUN, V3, P1459, DOI 10.1002/hep4.1419 Plauth M, 2019, CLIN NUTR, V38, P485, DOI 10.1016/j.clnu.2018.12.022 Romero-Gómez M, 2017, J HEPATOL, V67, P829, DOI 10.1016/j.jhep.2017.05.016 Ryan MC, 2013, J HEPATOL, V59, P138, DOI 10.1016/j.jhep.2013.02.012 Saeed N, 2019, NUTRIENTS, V11, DOI 10.3390/nu11123064 Simon TG, 2020, J HEPATOL, V72, P1062, DOI 10.1016/j.jhep.2019.12.022 Stepanova M, 2010, GUT, V59, P1410, DOI 10.1136/gut.2010.213553 Tajima R, 2019, NUTRITION, V61, P119, DOI 10.1016/j.nut.2018.10.016 Tosti V, 2018, J GERONTOL A-BIOL, V73, P318, DOI 10.1093/gerona/glx227 Vilar-Gomez E, 2015, GASTROENTEROLOGY, V149, P367, DOI 10.1053/j.gastro.2015.04.005 Wong VWS, 2018, J HEPATOL, V69, P1349, DOI 10.1016/j.jhep.2018.08.011 Ye Q, 2020, LANCET GASTROENTEROL, V5, P739, DOI 10.1016/S2468-1253(20)30077-7 Younossi ZM, 2016, HEPATOLOGY, V64, P73, DOI 10.1002/hep.28431 Younossi ZM, 2011, HEPATOLOGY, V53, P1874, DOI 10.1002/hep.24268 Zelber-Sagi S, 2018, J HEPATOL, V68, P1239, DOI 10.1016/j.jhep.2018.01.015 NR 45 TC 383 Z9 437 U1 2 U2 115 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0016-5085 EI 1528-0012 J9 GASTROENTEROLOGY JI Gastroenterology PD FEB PY 2021 VL 160 IS 3 BP 912 EP 918 DI 10.1053/j.gastro.2020.11.051 EA FEB 2021 PG 7 WC Gastroenterology & Hepatology WE Science Citation Index Expanded (SCI-EXPANDED) SC Gastroenterology & Hepatology GA QU6WE UT WOS:000627420700044 PM 33307021 HC Y HP N DA 2026-02-02 ER PT J AU Abenavoli, L Milic, N Peta, V Alfieri, F De Lorenzo, A Bellentani, S AF Abenavoli, Ludovico Milic, Natasa Peta, Valentina Alfieri, Francesco De Lorenzo, Antonino Bellentani, Stefano TI Alimentary regimen in non-alcoholic fatty liver disease: Mediterranean diet SO WORLD JOURNAL OF GASTROENTEROLOGY LA English DT Article DE Non-alcoholic fatty liver disease; Non-alcoholic steatohepatitis; Insulin resistance; Nutrition; Mediterranean diet ID HEPATIC INSULIN-RESISTANCE; LIFE-STYLE INTERVENTION; METABOLIC SYNDROME; RISK-FACTORS; WEIGHT-LOSS; CARDIOVASCULAR-DISEASE; OXIDATIVE-STRESS; CONTROLLED-TRIAL; IRON STORES; STEATOHEPATITIS AB Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease worldwide. The mechanisms of the underlying disease development and progression are awaiting clarification. Insulin resistance and obesity-related inflammation status, among other possible genetic, dietary, and lifestyle factors, are thought to play the key role. There is no consensus concerning the pharmacological treatment. However, the dietary nutritional management to achieve weight loss is an essential component of any treatment strategy. On the basis of its components, the literature reports on the effectiveness of the Mediterranean diet in reducing cardio-vascular risk and in preventing major chronic diseases, including obesity and diabetes. New evidence supports the idea that the Mediterranean diet, associated with physical activity and cognitive behaviour therapy, may have an important role in the prevention and the treatment of NAFLD. (C) 2014 Baishideng Publishing Group Inc. All rights reserved. C1 [Abenavoli, Ludovico; Peta, Valentina] Magna Graecia Univ Catanzaro, Dept Hlth Sci, I-88100 Catanzaro, Italy. [Milic, Natasa] Univ Novi Sad, Dept Pharm, Novi Sad 21000, Serbia. [Alfieri, Francesco] Univ MEIER, I-20124 Baranzate Di Bollate, MI, Italy. [De Lorenzo, Antonino] Univ Roma Tor Vergata, Dept Biomed & Prevent, Div Clin Nutr & Nutrigen, I-00133 Rome, Italy. [Bellentani, Stefano] Azienda USL Modena, Ramazzini Hosp, I-42100 Carpi, Modena, Italy. C3 Magna Graecia University of Catanzaro; University of Novi Sad; University of Rome Tor Vergata RP Abenavoli, L (通讯作者)，Magna Graecia Univ Catanzaro, Dept Hlth Sci, Campus Germaneto,Viale Europa, I-88100 Catanzaro, Italy. 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Gastroenterol. PD DEC 7 PY 2014 VL 20 IS 45 BP 16831 EP 16840 DI 10.3748/wjg.v20.i45.16831 PG 10 WC Gastroenterology & Hepatology WE Science Citation Index Expanded (SCI-EXPANDED) SC Gastroenterology & Hepatology GA AW1LK UT WOS:000346050700004 PM 25492997 OA hybrid DA 2026-02-02 ER PT J AU Carroll, AM Rotman, Y AF Carroll, Allison M. M. Rotman, Yaron TI Nutrition Literacy Is Not Sufficient to Induce Needed Dietary Changes in Nonalcoholic Fatty Liver Disease SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Article DE nonalcoholic fatty liver disease; nutrition; National Health and Nutrition Examination Survey ID MEDITERRANEAN DIET; MANAGEMENT AB INTRODUCTION:Dietary and lifestyle changes are the first line of therapy for nonalcoholic fatty liver disease (NAFLD), the most prevalent liver disease in the western world. Nutrition literacy is the ability to understand nutrition information and implement that knowledge. We aimed to compare indicators of nutrition literacy in subjects with and without NAFLD in a representative US cohort.METHODS:In a cross-sectional study using data from the National Health and Nutrition Examination Survey 2017-2018 cycle, we included 2,938 adult subjects with complete dietary and vibration-controlled transient elastography data and no alternative reason for hepatic steatosis. Nutrition literacy was assessed using questionnaires. Diet perception accuracy was assessed by comparing self-reported diet quality with objective diet quality scores-the Healthy Eating Index and alternative Mediterranean diet score-to assess real-world application of nutrition knowledge.RESULTS:Nutrition literacy was not different between subjects with or without NAFLD (P = 0.17): more than 90% of subjects reported using nutrition labels, and most of them correctly identified the meaning of daily value. Subjects with NAFLD had a lower-quality diet (Healthy Eating Index, P = 0.018; alternative Mediterranean diet, P = 0.013) and rated their diet as poorer (P < 0.001). On self-assessment, only 27.8% of subjects overestimated their diet quality, while 37.5% consumed more calories than their self-assessed needs. Both accuracy measures were similar between subjects with NAFLD and those without (P = 0.71 and 0.63, respectively). Subjects with NAFLD were more likely to report being advised to lose weight (42.1% vs 16.5%, P < 0.001) or to attempt losing weight (71.9% vs 60.9%, P < 0.001). Diet quality was not better in subjects with NAFLD who received dietary recommendations.DISCUSSION:Subjects with NAFLD have poor diet quality despite receiving medical recommendations to lose weight and having nutrition literacy and perception that are comparable with subjects without NAFLD. Educational approaches may not be sufficient to promote weight loss and improve diet quality in NAFLD. C1 [Carroll, Allison M. M.; Rotman, Yaron] NIDDK, Liver & Energy Metab Sect, Liver Dis Branch, NIH, Bethesda, MD 20892 USA. C3 National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) RP Rotman, Y (通讯作者)，NIDDK, Liver & Energy Metab Sect, Liver Dis Branch, NIH, Bethesda, MD 20892 USA. EM allison.carroll1@northwestern.edu RI Rotman, Yaron/AAK-8032-2020 OI Rotman, Yaron/0000-0002-7549-8216; Carroll, Allison/0000-0001-7137-987X FU Intramural NIH HHS [Z99 DK999999, ZIA DK075013] Funding Source: Medline; National Institute of Diabetes and Digestive and Kidney Diseases [ZIADK075013] Funding Source: NIH RePORTER CR Anania C, 2018, WORLD J GASTROENTERO, V24, P2083, DOI 10.3748/wjg.v24.i19.2083 [Anonymous], 2011, National Health and Nutrition Examination Survey Data [Anonymous], 2016, DIABETOLOGIA, V64, P1388, DOI DOI 10.1007/S00125-016-3902-Y [Anonymous], Food Patterns Equivalents Database [Anonymous], National Health and Nutrition Examination Survey: Plan and Operation 1999-2010 Bugianesi E, 2022, EAT WEIGHT DISORD-ST, V27, P1603, DOI 10.1007/s40519-021-01287-1 Burrows TL, 2019, FRONT ENDOCRINOL, V10, DOI 10.3389/fendo.2019.00850 Chalasani N, 2018, HEPATOLOGY, V67, P328, DOI [10.1002/hep.29367, 10.1038/s42255-021-00344-4] Chan WK, 2014, J GASTROEN HEPATOL, V29, P1470, DOI 10.1111/jgh.12557 Coleman-Jensen Alisha., 2018, Household Food Security in the United States in 2017 Food and Drug Administration, CAL NEW NUTR FACTS L Food and Nutrition Service, COST LIV AD COLA INF Fung TT, 2005, AM J CLIN NUTR, V82, P163 Gibbs HD, 2018, J NUTR EDUC BEHAV, V50, P247, DOI 10.1016/j.jneb.2017.10.008 Golovaty I, 2020, J NUTR, V150, P91, DOI 10.1093/jn/nxz212 Haigh L, 2019, CLIN GASTROENTEROL H, V17, P1364, DOI 10.1016/j.cgh.2018.10.044 Hardcastle SJ, 2015, NUTRIENTS, V7, P8712, DOI 10.3390/nu7105424 Higgs S, 2015, APPETITE, V86, P38, DOI 10.1016/j.appet.2014.10.021 Karpyn Allison E, 2019, UNSCN Nutr, V44, P46 Krause C, 2018, HEALTH PROMOT INT, V33, P378, DOI 10.1093/heapro/daw084 Krebs-Smith SM, 2018, J ACAD NUTR DIET, V118, P1591, DOI 10.1016/j.jand.2018.05.021 Lee WM, 2021, NUTRIENTS, V13, DOI 10.3390/nu13124453 Leoni S, 2018, WORLD J GASTROENTERO, V24, P3361, DOI 10.3748/wjg.v24.i30.3361 Lumley T., 2004, J STAT SOFTW, V9, P1, DOI [DOI 10.18637/JSS.V009.I08, 10.18637/jss.v009.i08] Marchello NJ, 2021, J NUTR EDUC BEHAV, V53, P1048, DOI 10.1016/j.jneb.2021.07.013 Moshfegh AJ, 2008, AM J CLIN NUTR, V88, P324 National Cancer Institute, HLTH EAT IND PER PER Promrat K, 2010, HEPATOLOGY, V51, P121, DOI 10.1002/hep.23276 Raper N, 2004, J FOOD COMPOS ANAL, V17, P545, DOI 10.1016/j.jfca.2004.02.013 Rhodes DG, 2013, AM J CLIN NUTR, V97, P958, DOI 10.3945/ajcn.112.044982 Robinson E, 2013, NUTR RES REV, V26, P166, DOI 10.1017/S0954422413000127 Shim JS, 2014, EPIDEMIOL HEALTH, V36, DOI 10.4178/epih/e2014009 Siddiqui MS, 2019, CLIN GASTROENTEROL H, V17, P156, DOI 10.1016/j.cgh.2018.04.043 Taylor MK, 2019, PUBLIC HEALTH NUTR, V22, P2157, DOI [10.1017/S1368980019001289, 10.1017/S1368] Trichopoulou A, 2003, NEW ENGL J MED, V348, P2599, DOI 10.1056/NEJMoa025039 Vilar-Gomez E, 2022, HEPATOLOGY, V75, P1491, DOI 10.1002/hep.32207 Waterworth SP, 2022, AM J HUM BIOL, V34, DOI 10.1002/ajhb.23743 Wehling H, 2019, J HEALTH PSYCHOL, V24, P2042, DOI 10.1177/1359105317714318 Yki-Järvinen H, 2014, LANCET DIABETES ENDO, V2, P901, DOI 10.1016/S2213-8587(14)70032-4 Younossi ZM, 2019, J HEPATOL, V70, P531, DOI 10.1016/j.jhep.2018.10.033 Zellner DA, 2006, PHYSIOL BEHAV, V87, P789, DOI 10.1016/j.physbeh.2006.01.014 NR 41 TC 6 Z9 7 U1 0 U2 8 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0002-9270 EI 1572-0241 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD AUG PY 2023 VL 118 IS 8 BP 1381 EP 1387 DI 10.14309/ajg.0000000000002182 PG 7 WC Gastroenterology & Hepatology WE Science Citation Index Expanded (SCI-EXPANDED) SC Gastroenterology & Hepatology GA P1YR5 UT WOS:001048672500018 PM 36719072 OA Green Submitted DA 2026-02-02 ER PT J AU Mahady, SE George, J AF Mahady, Suzanne E. George, Jacob TI Exercise and diet in the management of nonalcoholic fatty liver disease SO METABOLISM-CLINICAL AND EXPERIMENTAL LA English DT Article DE nonalcoholic fatty liver disease; diet; exercise; review ID COGNITIVE-BEHAVIORAL THERAPY; MEASURED SEDENTARY TIME; LOW-CARBOHYDRATE DIET; PHYSICAL-ACTIVITY; WEIGHT-LOSS; INSULIN SENSITIVITY; TRANS-FATTY; MEDITERRANEAN DIET; METABOLIC SYNDROME; HEPATIC STEATOSIS AB Nonalcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver condition worldwide, and is projected to become the leading cause for liver transplantation in the United States as early as 2020. The mainstay of treatment remains lifestyle modification with diet and exercise recommendations, as although some pharmacological treatments such as glitazones and Vitamin E have shown benefit, there are concerns regarding long term safety. The evidence base for dietary interventions in NAFLD such as the Mediterranean diet, omega-3 polyunsaturated fatty acids and coffee is mainly derived from observational data with questionable validity. Where trials exist, they have shown benefit for surrogate outcomes such as hepatic steatosis and insulin resistance, but no trials have been conducted with salient clinical outcomes such as reduction in progression to chronic liver disease. Benefit in surrogate outcomes has also been seen for aerobic, anaerobic and combined modality exercise but it remains unclear if one type is superior. Furthermore, a reduction in sedentary time appears equally important. To provide a sound evidence base for lifestyle recommendations to people with NAFLD, longer duration trials of standardized dietary or exercise interventions, and testing various doses, types and with liver related outcomes, are essential. (C) 2016 Elsevier Inc. All rights reserved. C1 [Mahady, Suzanne E.; George, Jacob] Univ Sydney, Westmead Millennium Inst Med Res, Storr Liver Ctr, Sydney, NSW 2006, Australia. [Mahady, Suzanne E.; George, Jacob] Univ Sydney, Westmead Hosp, Sydney, NSW 2006, Australia. [Mahady, Suzanne E.] Univ Sydney, Sydney Sch Publ Hlth, Sydney, NSW 2006, Australia. C3 University of Sydney; University of Sydney; NSW Health; Westmead Hospital; University of Sydney RP Mahady, SE (通讯作者)，Univ Sydney, Sydney Sch Publ Hlth, Sydney, NSW 2006, Australia. EM suzanne.mahady@sydney.edu.au RI George, Jacob/P-1496-2014 OI George, Jacob/0000-0002-8421-5476 FU National Health and Medical Research Council of Australia (NHMRC) Postgraduate Research Scholarship; NHMRC [1053206, 632630, 1049857]; National Health and Medical Research Council (NHMRC) [1049857, 632630, 1053206] Funding Source: National Health and Medical Research Council (NHMRC) FX SM is supported by a National Health and Medical Research Council of Australia (NHMRC) Postgraduate Research Scholarship. JG is supported by the Robert W. Storr Bequest to the Sydney Medical Foundation, University of Sydney, and grants from the NHMRC (1053206, 632630 and 1049857). 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59 U1 0 U2 41 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0026-0495 EI 1532-8600 J9 METABOLISM JI Metab.-Clin. Exp. PD AUG PY 2016 VL 65 IS 8 BP 1172 EP 1182 DI 10.1016/j.metabol.2015.10.032 PG 11 WC Endocrinology & Metabolism WE Science Citation Index Expanded (SCI-EXPANDED) SC Endocrinology & Metabolism GA DR4RH UT WOS:000379889400015 PM 26805014 DA 2026-02-02 ER PT J AU Sánchez-Calvo, B Cassina, A Mastrogiovanni, M Santos, M Trias, E Kelley, EE Rubbo, H Trostchansky, A AF Sanchez-Calvo, Beatriz Cassina, Adriana Mastrogiovanni, Mauricio Santos, Mariela Trias, Emiliano Kelley, Eric E. Rubbo, Homero Trostchansky, Andres TI Olive oil-derived nitro-fatty acids: protection of mitochondrial function in non-alcoholic fatty liver disease SO JOURNAL OF NUTRITIONAL BIOCHEMISTRY LA English DT Article DE Cell signaling; Mitochondria; Non-alcoholic fatty liver disease; Nutrition Liver; Nitroalkenes; High fat diet; Mediterranean diet ID OLEIC-ACID; NATURAL-HISTORY; OXIDATIVE-PHOSPHORYLATION; MEDITERRANEAN DIET; METABOLIC SYNDROME; SIGNALING ACTIONS; STEATOHEPATITIS; DYSFUNCTION; MODULATION; PROTEIN AB Non-alcoholic fatty liver disease (NAFLD) is characterized by excessive liver fat deposition in the absence of significant alcohol intake. Since extra virgin olive oil (EVOO) reduces fat accumulation, we analyzed the involvement of nitro-fatty acids (NO2-FA) on the beneficial effects of EVOO consumption on NAFLD. Nitro-fatty acids formation was observed during digestion in mice supplemented with EVOO and nitrite. Mice fed with a high-fat diet (HF) pre-sented lower plasma NO2-FA levels than normal chow, and circulating concentrations recovered when the HF diet was supplemented with 10% EVOO plus nitrite. Under NO2-FA formation conditions, liver hemoxygenase-1 expression significantly increased while decreased body weight and fat liver accumulation. Mitochondrial dysfunction plays a central role in the pathogenesis of NAFLD while NO2-FA has been shown to protect from mitochondrial oxidative damage. Accordingly, an improvement of respiratory indexes was observed when mice were supplemented with both EVOO plus nitrite. Liver mitochondrial complexes II and V activities were greater in mice with EVOO supplementation and further improved in the presence of nitrite. Overall, our results strongly suggest a positive correlation between NO2-OA formation from EVOO and the observed improvement of mitochondrial function in NAFLD. The formation of NO2-FA can account for the health benefits associated with EVOO consumption. (C) 2021 Elsevier Inc. All rights reserved. C1 [Sanchez-Calvo, Beatriz; Cassina, Adriana; Mastrogiovanni, Mauricio; Rubbo, Homero; Trostchansky, Andres] Univ Republica, Dept Bioquim, Fac Med, Montevideo, Uruguay. [Sanchez-Calvo, Beatriz; Cassina, Adriana; Mastrogiovanni, Mauricio; Rubbo, Homero; Trostchansky, Andres] Univ Republica, Ctr Invest Biomed CENIBIO, Fac Med, Montevideo, Uruguay. [Santos, Mariela] Univ Republica, Unidad React & Biomodelos Expt, Fac Med, Montevideo, Uruguay. [Sanchez-Calvo, Beatriz] Univ Republica, Dept Nutr Basica, Escuela Nutr, Montevideo, Uruguay. [Trias, Emiliano] Inst Pasteur Montevideo, Montevideo, Uruguay. [Kelley, Eric E.] West Virginia Univ, Dept Physiol & Pharmacol, Morgantown, WV 26506 USA. C3 Universidad de la Republica, Uruguay; Universidad de la Republica, Uruguay; Universidad de la Republica, Uruguay; Universidad de la Republica, Uruguay; Pasteur Network; Institut Pasteur de Montevideo; West Virginia University RP Trostchansky, A (通讯作者)，Avda Gral Flores 2125, Montevideo 11800, Uruguay. EM trocha@fmed.edu.uy RI ; Trostchansky, Andrés/I-5624-2019; Rubbo, Homero/HTM-3282-2023 OI Sánchez-Calvo, Beatriz/0000-0002-5298-1280; Trostchansky, Andrés/0000-0002-9721-7577; Trias, Emiliano/0000-0001-7187-511X FU ANII-Innovagro [FSA 1 2013 1 12622]; CSIC-Grupos [536]; CSIC I+D; NIH [P01 AG043376, P20 GM109098]; ANII-Uruguay; National Institute of Diabetes and Digestive and Kidney Diseases [R01DK124510] Funding Source: NIH RePORTER; National Institute of General Medical Sciences [P20GM109098] Funding Source: NIH RePORTER FX This work was supported by grants from ANII-Innovagro FSA 1 2013 1 12622 and CSIC-Grupos No 536 to HR and AT, and CSIC I+D to AT. BSC was supported by a postdoctoral fellowship by ANII-Uruguay. EEK was supported by NIH P01 AG043376 and P20 GM109098. 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Nutr. Biochem. PD AUG PY 2021 VL 94 AR 108646 DI 10.1016/j.jnutbio.2021.108646 EA MAY 2021 PG 9 WC Biochemistry & Molecular Biology; Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Biochemistry & Molecular Biology; Nutrition & Dietetics GA SP2HD UT WOS:000659494000008 PM 33838229 OA Green Submitted DA 2026-02-02 ER PT J AU Del Bo', C Perna, S Allehdan, S Rafique, A Saad, S AlGhareeb, F Rondanelli, M Tayyem, RF Marino, M Martini, D Riso, P AF Del Bo', Cristian Perna, Simone Allehdan, Sabika Rafique, Ayesha Saad, Sara AlGhareeb, Fahad Rondanelli, Mariangela Tayyem, Reema F. Marino, Mirko Martini, Daniela Riso, Patrizia TI Does the Mediterranean Diet Have Any Effect on Lipid Profile, Central Obesity and Liver Enzymes in Non-Alcoholic Fatty Liver Disease (NAFLD) Subjects? A Systematic Review and Meta-Analysis of Randomized Control Trials SO NUTRIENTS LA English DT Review DE Mediterranean diet; nonalcoholic fatty liver disease; lipid profile; liver function; human interventions ID ENDOTHELIAL FUNCTION; HEPATIC STEATOSIS; LIFE-STYLE; POLYPHENOLS; ACIDS; MANAGEMENT; ADHERENCE; RISK; LIPOGENESIS; OUTCOMES AB The effectiveness of the Mediterranean diet (MD) in non-alcoholic fatty liver disease (NAFLD) subjects has been evaluated in several randomized controlled trials (RCTs). This systematic review and meta-analysis aimed to evaluate the overall effects of MD intervention in a cohort of NAFLD patients targeting specific markers such as central obesity, lipid profile, liver enzymes and fibrosis, and intrahepatic fat (IHF). Google Scholar, PubMed, and Scopus were explored to collect relevant studies from the last 10 years. RCTs with NAFLD subjects were included in this systematic review with a mean intervention duration from 6 weeks to 1 year, and different intervention strategies, mainly including energy restriction MD (normal or low glycaemic index), low-fat MD with increased monounsaturated and polyunsaturated fatty acids, and increased exercise expenditure. The outcomes measured in this meta-analysis were gamma-glutamyl transferase (GGT), alanine aminotransferase (ALT), total cholesterol (TC), waist circumference (WC), and liver fibrosis. Ten randomized controlled trials, which involved a total of 737 adults with NAFLD, were included. According to the results, the MD seems to decrease the liver stiffness (kPa) by -0.42 (CI95% -0.92, 0.09) (p = 0.10) and significantly reduce the TC by -0.46 mg/dl (CI95% -0.55, -0.38) (p = 0.001), while no significant findings were documented for liver enzymes and WC among patients with NAFLD. In conclusion, the MD might reduce indirect and direct outcomes linked with NAFLD severity, such as TC, liver fibrosis, and WC, although it is important to consider the variations across trials. Further RCTs are necessary to corroborate the findings obtained and provide further evidence on the role of the MD in the modulation of other disorders related to NAFLD. C1 [Del Bo', Cristian; Perna, Simone; Marino, Mirko; Martini, Daniela; Riso, Patrizia] Univ Milan, Dept Food Environm & Nutr Sci DeFENS, Div Human Nutr, I-20133 Milan, Italy. [Allehdan, Sabika; Rafique, Ayesha; Saad, Sara; AlGhareeb, Fahad] Univ Bahrain, Coll Sci, Dept Biol, Sakhir Campus,POB 32038, Zallaq, Bahrain. [Rondanelli, Mariangela] IRCCS Mondino Fdn, I-27100 Pavia, Italy. [Rondanelli, Mariangela] Univ Pavia, Dept Publ Hlth Expt & Forens Med, Unit Human & Clin Nutr, I-27100 Pavia, Italy. [Tayyem, Reema F.] Qatar Univ, Coll Hlth Sci, Dept Human Nutr, QU Hlth, POB 2713, Doha, Qatar. C3 University of Milan; University of Bahrain; IRCCS Fondazione Casimiro Mondino; University of Pavia; Qatar University RP Perna, S (通讯作者)，Univ Milan, Dept Food Environm & Nutr Sci DeFENS, Div Human Nutr, I-20133 Milan, Italy. EM simone.perna@unimi.it; sallehdan@uob.edu.bh; ayesha.rafique121@hotmail.com; helal.sara95@gmail.com; mariangela.rondanelli@unipv.it; reema.tayyem@qu.edu.qa; mirko.marino@unimi.it RI ; DEL BO', CRISTIAN/AFT-1534-2022; Perna, Simone/Y-8892-2018; martini, daniela/S-2499-2019; Riso, Patrizia/AAC-2072-2019; MARINO, MIRKO/AAI-5389-2020; Tayyem, Reema/AAA-5326-2019; rondanelli, Mariangela/AGD-6274-2022 OI Mohammad Rafique, Ayesha/0000-0002-7585-169X; DEL BO', CRISTIAN/0000-0001-7562-377X; ALGhareeb, Fahad/0009-0008-3143-6786; Perna, Simone/0000-0002-2720-1473; martini, daniela/0000-0001-8298-926X; Riso, Patrizia/0000-0002-9204-7257; MARINO, MIRKO/0000-0001-9913-4380; Tayyem, Reema/0000-0003-1640-0511; rondanelli, Mariangela/0000-0001-8336-4851 CR Abbate M, 2021, NUTRIENTS, V13, DOI 10.3390/nu13020629 Abenavoli L, 2017, NUTRIENTS, V9, DOI 10.3390/nu9080870 Agarwala A, 2022, PROG CARDIOVASC DIS, V75, P49, DOI 10.1016/j.pcad.2022.11.003 Akhlaghi M, 2016, PHYTOTHER RES, V30, P1559, DOI 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10.3390/nu15102250 PG 18 WC Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Nutrition & Dietetics GA H6GV2 UT WOS:000996934400001 PM 37242133 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Zelber-Sagi, S Salomone, F Mlynarsky, L AF Zelber-Sagi, Shira Salomone, Federico Mlynarsky, Liat TI The Mediterranean dietary pattern as the diet of choice for non-alcoholic fatty liver disease: Evidence and plausible mechanisms SO LIVER INTERNATIONAL LA English DT Review DE fish oil; fruits; Mediterranean diet; non-alcoholic fatty liver disease; olive oil; vegetables ID PROCESSED MEAT CONSUMPTION; WHOLE-GRAIN WHEAT; MODEST ALCOHOL-CONSUMPTION; HEPATIC OXIDATIVE STRESS; OLIVE OIL; INSULIN-RESISTANCE; RISK-FACTORS; CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; DIABETES-MELLITUS AB Non-alcoholic fatty liver disease (NAFLD) has become a major global health burden, leading to increased risk for cirrhosis, hepatocellular carcinoma, type-2 diabetes and cardiovascular disease. Lifestyle intervention aiming at weight reduction is the most established treatment. However, changing the dietary composition even without weight loss can also reduce steatosis and improve metabolic alterations as insulin resistance and lipid profile. The Mediterranean diet (MD) pattern has been proposed as appropriate for this goal, and was recommended as the diet of choice for the treatment of NAFLD by the EASL-EASD-EASO Clinical Practice Guidelines. The MD has an established superiority in long term weight reduction over low fat diet, but it improves metabolic status and steatosis even without it. However, the effect on liver inflammation and fibrosis was tested only in few observational studies with positive results. Furthermore, considering the strong association between NAFLD and diabetes and CVD, the MD has a highly established advantage in prevention of these diseases, demonstrated in randomized clinical trials. The individual components of the MD such as olive oil, fish, nuts, whole grains, fruits, and vegetables, have been shown to beneficially effect or negatively correlate with NAFLD, while consumption of components that characterize a Western dietary pattern as soft drinks, fructose, meat and saturated fatty acids have been shown to have detrimental association with NAFLD. In this review we will cover the epidemiological evidence and the plausible molecular mechanisms by which the MD as a whole and each of its components can be of benefit in NAFLD. C1 [Zelber-Sagi, Shira] Univ Haifa, Sch Publ Hlth, Haifa, Israel. [Zelber-Sagi, Shira; Mlynarsky, Liat] Tel Aviv Med Ctr & Sch Med, Liver Unit, Dept Gastroenterol, Tel Aviv, Israel. [Salomone, Federico] Azienda Sanit Prov Catania, Osped Acireale, Div Gastroenterol, Catania, Italy. [Mlynarsky, Liat] Tel Aviv Univ, Sackler Fac Med, Tel Aviv, Israel. C3 University of Haifa; Tel Aviv University; Sackler Faculty of Medicine; Tel Aviv University; Sackler Faculty of Medicine RP Zelber-Sagi, S (通讯作者)，Tel Aviv Med Ctr & Sch Med, Liver Unit, Dept Gastroenterol, Tel Aviv, Israel. 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PD JUL PY 2017 VL 37 IS 7 BP 936 EP 949 DI 10.1111/liv.13435 PG 14 WC Gastroenterology & Hepatology WE Science Citation Index Expanded (SCI-EXPANDED) SC Gastroenterology & Hepatology GA EY4CB UT WOS:000403922800001 PM 28371239 DA 2026-02-02 ER PT J AU Zelber-Sagi, S AF Zelber-Sagi, Shira TI Dietary Treatment for NAFLD: New Clinical and Epidemiological Evidence and Updated Recommendations SO SEMINARS IN LIVER DISEASE LA English DT Review DE dietary composition; fructose; ultra-processed food; processed meat ID FATTY LIVER-DISEASE; GLYCATION END-PRODUCTS; LIFE-STYLE MODIFICATION; HEPATOCELLULAR-CARCINOMA; RISK-FACTORS; MEDITERRANEAN DIET; HETEROCYCLIC AMINES; CARDIOVASCULAR-DISEASE; PHYSICAL-ACTIVITY; HEPATIC-FIBROSIS AB The key factor in preventing and treating nonalcoholic fatty liver disease (NAFLD) is a holistic lifestyle modification approach, encompassing diet based on healthy eating patterns of unprocessed foods, exercise, balanced drinking, and smoking habits. The Mediterranean diet and other healthy dietary patterns can reduce liver fat and may be related with lower disease progression. The type of diet should be tailored to the patient's cultural and personal preferences. Changing dietary composition without reducing caloric intake may offer an additional and sometimes more feasible alternative, so that the nutritional treatment incorporates, but is not focused on, weight reduction goals. The growing global consumption of ultra-processed foods, which is the polar opposite of the Mediterranean diet and its concept of home-based cooking, poses a great challenge in the prevention of NAFLD and probably hepatocellular carcinoma. This review will cover the most updated clinical and epidemiological evidence for lifestyle treatment in NAFLD and provide practical treatment tools. C1 [Zelber-Sagi, Shira] Univ Haifa, Sch Publ Hlth, Fac Social Welf & Hlth Sci, 199 Aba Khoushy Ave, IL-3498838 Haifa, Israel. C3 University of Haifa RP Zelber-Sagi, S (通讯作者)，Univ Haifa, Sch Publ Hlth, Fac Social Welf & Hlth Sci, 199 Aba Khoushy Ave, IL-3498838 Haifa, Israel. 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Liver Dis. PD AUG PY 2021 VL 41 IS 03 BP 248 EP 262 DI 10.1055/s-0041-1729971 EA JUN 2021 PG 15 WC Gastroenterology & Hepatology WE Science Citation Index Expanded (SCI-EXPANDED) SC Gastroenterology & Hepatology GA TQ5AB UT WOS:000662610400001 PM 34139786 DA 2026-02-02 ER PT J AU Chen, VL Du, XM Oliveri, A Chen, YH Kuppa, A Halligan, BD Province, MA Speliotes, EK AF Chen, Vincent L. Du, Xiaomeng Oliveri, Antonino Chen, Yanhua Kuppa, Annapurna Halligan, Brian D. Province, Michael A. Speliotes, Elizabeth K. TI Genetic risk accentuates dietary effects on hepatic steatosis, inflammation and fibrosis in a population-based cohort SO JOURNAL OF HEPATOLOGY LA English DT Article DE SLD; gene-environment interaction; PNPLA3; TM6SF2; polygenic risk score; 24 hour recall; Mediterranean diet ID FATTY LIVER-DISEASE; GENOME-WIDE ASSOCIATION; NONALCOHOLIC STEATOHEPATITIS; HEPATOCELLULAR-CARCINOMA; MEDITERRANEAN DIET; PREVALENCE; PATTERNS; PNPLA3; TRANSPLANTATION; INDIVIDUALS AB Background & Aims: Steatotic liver disease (SLD), characterized by elevated liver fat content (LFC), is influenced by genetics and diet. However, whether diet has a differential effect based on genetic risk is not well-characterized. We aimed to determine how genetic factors interact with diet to affect SLD in a large national biobank. Methods: We included UK Biobank participants with dietary intake measured by 24-hour recall and genotyping. The primary predictors were dietary pattern, PNPLA3-rs738409-G, TM6SF2-rs58542926-T, a 16-variant hepatic steatosis polygenic risk score (PRS), and gene-environment interactions. The primary outcome was LFC, and secondary outcomes were iron-controlled T1 time (cT1, a measure of liver inflammation and fibrosis) and liver-related events/mortality. Results: A total of 21,619 participants met inclusion criteria. In non-interaction models, Mediterranean diet and intake of fruit/ vegetables/legumes and fish associated with lower LFC, while higher red/processed meat intake and all genetic predictors associated with higher LFC. In interaction models, all genetic predictors interacted with Mediterranean diet and fruit/vegetable/ legume intake, while the steatosis PRS interacted with fish intake and the TM6SF2 genotype interacted with red/processed meat intake, to affect LFC. Dietary effects on LFC were up to 3.8-fold higher in PNPLA3-rs738409-GG vs. -CC individuals, and 1.4-3.0- fold higher in the top vs. bottom quartile of the steatosis PRS. Gene-diet interactions were stronger in participants with vs. without overweight. The steatosis PRS interacted with Mediterranean diet and fruit/vegetable/legume intake to affect cT1 and most dietary and genetic predictors associated with risk of liver-related events or mortality by age 70. Conclusions: Effects of diet on LFC and cT1 were markedly accentuated in patients at increased genetic risk for SLD, implying dietary interventions may be more impactful in these populations. (c) 2024 The Author(s). Published by Elsevier B.V. on behalf of European Association for the Study of the Liver. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). C1 [Chen, Vincent L.; Du, Xiaomeng; Oliveri, Antonino; Chen, Yanhua; Kuppa, Annapurna; Halligan, Brian D.; Speliotes, Elizabeth K.] Univ Michigan Hlth Syst, Div Gastroenterol & Hepatol, 1150 West Med Ctr Dr, Ann Arbor, MI 48109 USA. [Province, Michael A.] Washington Univ, Sch Med, Dept Genet, St Louis, MO 63130 USA. [Speliotes, Elizabeth K.] Univ Michigan, Med Sch, Dept Computat Med & Bioinformat, Ann Arbor, MI 48109 USA. C3 University of Michigan System; University of Michigan; Washington University (WUSTL); University of Michigan System; University of Michigan RP Speliotes, EK (通讯作者)，Univ Michigan Hlth Syst, Div Gastroenterol & Hepatol, 1150 West Med Ctr Dr, Ann Arbor, MI 48109 USA. EM espeliot@med.umich.edu RI ; Halligan, Brian/N-5166-2015; Kuppa, Annapurna/AAW-4624-2020 OI Oliveri, Antonino/0000-0003-2621-6443; Halligan, Brian/0000-0002-9553-4253; Province, Michael/0000-0001-6102-774X; Chen, Vincent/0000-0002-0157-6066; FU American Association for the Study of Liver Diseases Clinical, Translational and Outcomes Research Award; NIDDK [K08 DK132312]; NIH [R01 DK106621, R01 DK107904, R01DK128871, R01DK131787]; University of Michigan Department of Internal Medicine; UKBB [18120] FX Financial support VLC was supported in part by an American Association for the Study of Liver Diseases Clinical, Translational and Outcomes Research Award and NIDDK (K08 DK132312) . Analyses in the UKBB were done under approved project 18120 (EKS) . EKS, AO, YC, AK, XD, and BH are supported by NIH grants R01 DK106621, R01 DK107904, R01DK128871, R01DK131787 (all to EKS) and/or The University of Michigan Department of Internal Medicine. 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PD SEP PY 2024 VL 81 IS 3 DI 10.1016/j.jhep.2024.03.045 EA AUG 2024 PG 11 WC Gastroenterology & Hepatology WE Science Citation Index Expanded (SCI-EXPANDED) SC Gastroenterology & Hepatology GA E2P7V UT WOS:001301479600001 PM 38582304 OA Green Submitted, hybrid DA 2026-02-02 ER PT J AU Biccirè, FG Bucci, T Menichelli, D Cammisotto, V Pignatelli, P Carnevale, R Pastori, D AF Biccire, Flavio Giuseppe Bucci, Tommaso Menichelli, Danilo Cammisotto, Vittoria Pignatelli, Pasquale Carnevale, Roberto Pastori, Daniele TI Mediterranean Diet: A Tool to Break the Relationship of Atrial Fibrillation with the Metabolic Syndrome and Non-Alcoholic Fatty Liver Disease SO NUTRIENTS LA English DT Article DE diet; atrial fibrillation; metabolic syndrome; NAFLD ID OXIDATIVE STRESS; CHOCOLATE CONSUMPTION; ALCOHOL-CONSUMPTION; VITAMIN-K; CARDIOVASCULAR EVENTS; DANISH DIET; RISK; ASSOCIATION; FISH; PREVALENCE AB Atrial fibrillation (AF) is the most common supraventricular arrhythmia associated with increased cardiovascular and non-cardiovascular morbidity and mortality. As multiple factors may predispose the onset of AF, the prevention of the occurrence, recurrence and complications of this arrhythmia is still challenging. In particular, a high prevalence of cardio-metabolic comorbidities such as the metabolic syndrome (MetS) and in its hepatic manifestation, the non-alcoholic fatty liver disease (NAFLD), have been described in the AF population. A common pathogenetic mechanism linking AF, MetS and NAFLD is represented by oxidative stress. For this reason, in the past decades, numerous studies have investigated the effect of different foods/nutrients with antioxidant properties for the prevention of, and their therapeutic role is still unclear. In this narrative comprehensive review, we will summarize current evidence on (1) the association between AF, MetS and NAFLD (2) the antioxidant role of Mediterranean Diet and its components for the prevention of AF and (3) the effects of Mediterranean Diet on MetS components and NAFLD. C1 [Biccire, Flavio Giuseppe; Bucci, Tommaso] Sapienza Univ Rome, Dept Gen & Specialized Surg Paride Stefanini, I-00161 Rome, Italy. [Menichelli, Danilo; Cammisotto, Vittoria; Pignatelli, Pasquale; Pastori, Daniele] Sapienza Univ Rome, Dept Clin Internal Anesthesiol & Cardiovasc Sci, I-00161 Rome, Italy. [Pignatelli, Pasquale; Carnevale, Roberto] Mediterranea Cardioctr, I-80122 Naples, Italy. [Carnevale, Roberto] Sapienza Univ Rome, Dept Med Surg Sci & Biotechnol, I-04100 Latina, Italy. C3 Sapienza University Rome; Sapienza University Rome; Sapienza University Rome RP Pastori, D (通讯作者)，Sapienza Univ Rome, Dept Clin Internal Anesthesiol & Cardiovasc Sci, I-00161 Rome, Italy. EM flaviogiuseppe.biccire@uniroma1.it; tommaso.bucci@uniroma1.it; danilo.menichelli@uniroma1.it; vittoria.cammisotto@uniroma1.it; pasquale.pignatelli@uniroma1.it; roberto.carnevale@uniroma1.it; daniele.pastori@uniroma1.it RI pastori, daniele/J-7087-2016; Bucci, Tommaso/ABA-4162-2021; Biccirè, Flavio Giuseppe/CAH-5345-2022; Cammisotto, Vittoria/W-5910-2019; pignatelli, pasquale/K-2116-2016; Carnevale, Roberto/JMC-1138-2023; Menichelli, Danilo/W-5498-2018 OI pastori, daniele/0000-0001-6357-5213; Bucci, Tommaso/0000-0003-2895-6234; Cammisotto, Vittoria/0000-0003-1966-5945; pignatelli, pasquale/0000-0002-2265-7455; Carnevale, Roberto/0000-0002-6216-9595; Menichelli, Danilo/0000-0001-9467-5903 FU Sapienza Progetto Medio di Ateneo 2019 [000031_19_RS_PAST ORI_PROGETTI_MEDI _2019] FX The article was supported by Sapienza Progetto Medio di Ateneo 2019 granted to Daniele Pastori (grant number 000031_19_RS_PAST ORI_PROGETTI_MEDI _2019). 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Al-Mushiki, Gaber M. Tamrakar, Rashi Abdullahi, Gibirima Lin, Yue-Dong Tang, Xian-Yan TI Fasting, Nutrition and Weight Loss: An Approach to Refine Non-Alcoholic Fatty Liver Disease SO JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY LA English DT Review DE fasting; non-alcoholic fatty liver disease (NAFLD); nutrition; obesity; weight loss ID MEDITERRANEAN DIET; MOLECULAR-MECHANISMS; CALORIC RESTRICTION; BARIATRIC SURGERY; HEPATIC STEATOSIS; RAMADAN; MANAGEMENT; OBESITY; PREVALENCE; DIAGNOSIS AB Non-alcoholic fatty liver disease (NAFLD) is considered as one of the most common causes of chronic liver disease. It includes a group of conditions associated with fat deposition in liver cells. Also, NAFLD is strongly associated with obesity and insulin resistance (IR). Until now, there is no pharmacological treatment validated for this disease. Fasting, nutritional intervention, and weight loss can be considered the first line in treating hepatic steatosis. This review is based on the scientific evidence showing the results of these interventions in the past years. The results include fasting and nutritional support for NAFLD treatment in humans. In clinical trials and cohort studies, an increase in hepatic fat content was correlated with a weight loss of at least 7% and a diet resembling the Mediterranean diet (MD) improving hepatic biomarkers and histological regression of NAFLD. Fasting is a dietary approach known to improve the lipid profile in healthy and obese populations by decreasing overall cholesterol, triglycerides, LDL, and increasing HDL. Bariatric surgery helps improve liver fat content in patients with serious health problems due to overweight. C1 [Al-Samhari, Galal A.; Al-Mushiki, Gaber M.; Lin, Yue-Dong; Tang, Xian-Yan] Guangxi Med Univ, Sch Publ Hlth, Nanning, Guangxi Zhuang, Peoples R China. [Tamrakar, Rashi; Abdullahi, Gibirima] Guangxi Med Univ, Affiliated Hosp 1, Internal Med, Nanning, Guangxi Zhuang, Peoples R China. C3 Guangxi Medical University; Guangxi Medical University RP Tang, XY (通讯作者)，Guangxi Med Univ, Sch Publ Hlth, Nanning, Guangxi Zhuang, Peoples R China. EM tangxianyan0746@163.com RI abdullahi, gibirima/GQY-6769-2022 FU National Natural Sci-ence Foundation of China [81502890, 81960615]; China Medical Board [14-202, 19-307] FX This study was funded by the National Natural Sci-ence Foundation of China (Grant No. 81502890 and 81960615) , and the China Medical Board (Grant No. 14-202 and 19-307) . The sponsors had no role in study design, data collection, data analysis, or manuscript writing. 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Nutr. Sci. Vitaminol. PY 2021 VL 67 IS 6 BP 366 EP 374 PG 9 WC Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Nutrition & Dietetics GA YC6YT UT WOS:000739835200002 PM 34980714 OA gold DA 2026-02-02 ER PT J AU Pimentel, CFMG Lai, M AF Pimentel, Carolina Frade Magalhaes Girardin Lai, Michelle TI Nutrition Interventions for Chronic Liver Diseases and Nonalcoholic Fatty Liver Disease SO MEDICAL CLINICS OF NORTH AMERICA LA English DT Article DE Nonalcoholic liver disease; Nutrition; Diet; Liver disease; Lifestyle intervention; Liver cirrhosis ID SUBJECTIVE GLOBAL ASSESSMENT; WEIGHT-LOSS; HEPATOCELLULAR-CARCINOMA; ALANINE AMINOTRANSFERASE; CARBOHYDRATE INTAKE; MEDITERRANEAN DIET; INSULIN-RESISTANCE; METABOLIC SYNDROME; HEPATIC STEATOSIS; GLYCEMIC INDEX AB The progressively increasing rates of obesity have led to a worldwide epidemic of nonalcoholic fatty liver disease (NAFLD), the hepatic manifestation of the metabolic syndrome. It is currently the most common cause of liver disease worldwide and projected to be the leading indication for liver transplantation in the United States by 2020. NAFLD is associated with both liver-related and overall mortality. Undoubtedly, nutrition interventions are key in the treatment of NAFLD, to reverse the disease, and prevent disease progression, complications, and associated comorbidities, including cardiovascular disease and diabetes. C1 [Pimentel, Carolina Frade Magalhaes Girardin; Lai, Michelle] Harvard Univ, Beth Israel Deaconess Med Ctr, Ctr Liver, 110 Francis St, Boston, MA 02115 USA. C3 Harvard University; Harvard University Medical Affiliates; Beth Israel Deaconess Medical Center RP Pimentel, CFMG (通讯作者)，Harvard Univ, Beth Israel Deaconess Med Ctr, Ctr Liver, 110 Francis St, Boston, MA 02115 USA. 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Clin. N. Am. PD NOV PY 2016 VL 100 IS 6 BP 1303 EP + DI 10.1016/j.mcna.2016.06.010 PG 26 WC Medicine, General & Internal WE Science Citation Index Expanded (SCI-EXPANDED) SC General & Internal Medicine GA EB8JO UT WOS:000387637500012 PM 27745596 DA 2026-02-02 ER PT J AU Ma, JT Hennein, R Liu, CY Long, MT Hoffmann, U Jacques, PF Lichtenstein, AH Hu, FB Levy, D AF Ma, Jiantao Hennein, Rachel Liu, Chunyu Long, Michelle T. Hoffmann, Udo Jacques, Paul F. Lichtenstein, Alice H. Hu, Frank B. Levy, Daniel TI Improved Diet Quality Associates With Reduction in Liver Fat, Particularly in Individuals With High Genetic Risk Scores for Nonalcoholic Fatty Liver Disease SO GASTROENTEROLOGY LA English DT Article DE Diet Quality; Fatty Liver; Steatosis; Prevention ID CORONARY-HEART-DISEASE; CARDIOVASCULAR-DISEASE; MEDITERRANEAN DIET; DIABETES-MELLITUS; HEPATIC STEATOSIS; PHYSICAL-ACTIVITY; WIDE ASSOCIATION; NAFLD; CONSUMPTION AB BACKGROUND & AIMS: Dietary modification has been recommended for treatment of nonalcoholic fatty liver disease (NAFLD), although it is not clear whether improving diet quality can prevent its development. We performed a prospective study to examine the association between diet quality change and change in liver fat. We also examined the association between genetic risk score and liver fat change in individuals with different levels of diet quality change. METHODS: Our study included 1521 participants who attended the seventh and eighth examinations (1998-2001 and 2005-2008) of the second-generation cohort or attended the first and second examinations (2002-2005 and 2008-2011) of the third-generation cohort in the Framingham Heart Study. The self-administered semiquantitative 126-item Harvard food frequency questionnaire was used to determine dietary intake in the year leading up to an examination. We assessed levels of liver fat using liver-phantom ratio (LPR) on computed tomography images from 2002 through 2005 and again from 2008 through 2011. LPR values are inversely related to liver fat: increased LPR indicates decreased liver fat. We examined associations of changes in 2 diet scores, the Mediterranean-style diet score (MDS) and Alternative Healthy Eating Index (AHEI), with changes in liver fat and new-onset fatty liver. We evaluated interactions between diet score change and a weighted genetic risk score for NAFLD, determined based on multiple single-nucleotide polymorphisms identified in genome-wide association studies of NAFLD. The primary outcome was change in LPR between baseline and follow-up measurement. RESULTS: For each 1 standard deviation increase in MDS, the LPR increased (meaning liver fat decreased) by 0.57 (95% confidence interval [CI] 0.27-0.86; P < .001) and the odds for incident fatty liver decreased by 26% (95% CI 10%-39%; P <1/4>.002). For each 1 standard deviation increase in AHEI, LPR increased by 0.56 (95% CI 0.29-0.84; WHAT YOU NEED TO KNOW BACKGROUND AND CONTEXT It is not clear whether improving diet quality prevent development of nonalcoholic fatty liver disease (NAFLD). NEW FINDINGS Increasing diet quality is associated with less liver fat accumulation and reduced risk for new-onset fatty liver, particularly in individuals with a high genetic risk for NAFLD. LIMITATIONS Limited generalizability to other populations. IMPACT Improving diet quality is an important strategy for NAFLD prevention. P < .001) and the odds for incident fatty liver decreased by 21% (95% CI 5%-35%; P = .02). Increased diet scores were also associated with reduced odds of developing more-advanced fatty liver. Higher genetic risk scores were associated with increased liver fat accumulation in participants who had decreased MDS (P < .001) or AHEI scores (P = .001), but not in those with stable or improved diet scores (P for gene-diet interaction < .001). CONCLUSIONS: In an analysis of participants in the Framingham Heart Study, increasing diet quality, determined based on MDS and AHEI scores, is associated with less liver fat accumulation and reduced risk for new-onset fatty liver. An improved diet is particularly important for individuals with a high genetic risk for NAFLD. C1 [Ma, Jiantao; Hennein, Rachel; Liu, Chunyu; Levy, Daniel] NHLBI, Populat Sci Branch, NIH, Bldg 10, Bethesda, MD 20892 USA. [Ma, Jiantao; Hennein, Rachel; Liu, Chunyu; Levy, Daniel] Framingham Heart Dis Epidemiol Study, Framingham, MA 01702 USA. [Long, Michelle T.] Boston Univ, Sch Med, Evans Dept Med, Sect Gastroenterol, Boston, MA 02118 USA. [Hoffmann, Udo] Harvard Med Sch, Massachusetts Gen Hosp, Dept Radiol, Boston, MA USA. [Jacques, Paul F.] Tufts Univ, USDA Human Nutr Res Ctr, Nutr Epidemiol Program, Boston, MA 02111 USA. [Jacques, Paul F.; Lichtenstein, Alice H.] Tufts Univ, USDA Human Nutr Res Ctr, Cardiovasc Nutr Lab, Boston, MA 02111 USA. [Hu, Frank B.] Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA. C3 National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI); Framingham Heart Study; Boston University; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Massachusetts General Hospital; United States Department of Agriculture (USDA); Tufts University; United States Department of Agriculture (USDA); Tufts University; Harvard University; Harvard T.H. Chan School of Public Health RP Levy, D (通讯作者)，NHLBI, Populat Sci Branch, NIH, Bldg 10, Bethesda, MD 20892 USA.; Levy, D (通讯作者)，Framingham Heart Dis Epidemiol Study, Framingham, MA 01702 USA. EM levyd@nhlbi.nih.gov RI Hu, Frank/C-1919-2013; Levy, Daniel/ABB-2752-2021; Long, Michelle/H-3801-2019 OI Hennein, Rachel/0000-0001-6855-0402; Ma, Jiantao/0000-0001-7478-7203; Levy, Daniel/0000-0003-1843-8724; Long, Michelle/0000-0001-6131-3981 FU National Heart, Lung and Blood Institute's Framingham Heart Study [N01-HC-25195]; Affymetrix for genotyping services [N02-HL-6-4278]; Division of Intramural Research; National Heart Lung and Blood Institute [K22HL135075] Funding Source: NIH RePORTER; National Institute of Diabetes and Digestive and Kidney Diseases [K23DK113252] Funding Source: NIH RePORTER FX This work was supported by the National Heart, Lung and Blood Institute's Framingham Heart Study (Contract No. N01-HC-25195) and its contract with Affymetrix for genotyping services (Contract No. N02-HL-6-4278). Several authors are employees of the National Heart, Lung and Blood Institute and their research is supported by its Division of Intramural Research (Jianto Ma, Rachel Hennein, Chunyu Liu, Daniel Levy). CR Altshuler DM, 2015, NATURE, V526, P68, DOI 10.1038/nature15393 Anstee QM, 2016, GASTROENTEROLOGY, V150, P1728, DOI 10.1053/j.gastro.2016.01.037 Anstee QM, 2013, NAT REV GASTRO HEPAT, V10, P330, DOI 10.1038/nrgastro.2013.41 Chalasani N, 2010, GASTROENTEROLOGY, V139, P1567, DOI 10.1053/j.gastro.2010.07.057 Chalasani NP, 2017, HEPATOLOGY, V66, p303A, DOI 10.1002/cld.722 Charlton M, 2004, CLIN GASTROENTEROL H, V2, P1048, DOI 10.1016/S1542-3565(04)00440-9 Chiuve SE, 2012, J NUTR, V142, P1009, DOI 10.3945/jn.111.157222 Davis JN, 2010, AM J CLIN NUTR, V92, P1522, DOI 10.3945/ajcn.2010.30185 De Filippis F, 2016, GUT, V65, P1812, DOI 10.1136/gutjnl-2015-309957 Eckel R. 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TI Nutritional Approaches for the Management of Nonalcoholic Fatty Liver Disease: An Evidence-Based Review SO NUTRIENTS LA English DT Review DE DASH diet; dietary therapy; intermittent fasting; ketogenic diet; low-carbohydrate diet; low-fat diet; Mediterranean diet; nonalcoholic fatty liver disease; nutritional management; obesity ID STOP HYPERTENSION DASH; RANDOMIZED CONTROLLED-TRIAL; MEDITERRANEAN DIET; HEPATIC STEATOSIS; WEIGHT-LOSS; LOW-CARBOHYDRATE; BLOOD-PRESSURE; AMERICAN ASSOCIATION; BODY-COMPOSITION; KETOGENIC DIET AB Nonalcoholic fatty liver disease (NAFLD) is on the rise worldwide representing a public health issue. Its coexistence with obesity and other metabolic alterations is highly frequent. Therefore, current therapy interventions for NAFLD are mainly focused on progressive weight loss through modulation of overall calorie intake with or without specific macronutrient adjustments. Furthermore, other relevant nutritional interventions are built on food selection and time-restricted eating. Since every strategy might bring different results, choosing the optimal diet therapy for a patient is a complicated task, because NAFLD is a multifactorial complex disease. Importantly, some factors need to be considered, such as nutrition-based evidence in terms of hepatic morphophysiological improvements as well as adherence of the patient to the meal plan and adaptability in their cultural context. Thus, the purpose of this review is to explore and compare the subtleties and nuances of the most relevant clinical practice guidelines and the nutritional approaches for the management of NAFLD with a special attention to tangible outcomes and long-term adherence. C1 [Parra-Vargas, Marcela; Jimenez-Chillaron, Josep C.] Inst Recerca St Joan de Deu, Div Endocrinol, Barcelona 08950, Spain. [Parra-Vargas, Marcela; Jimenez-Chillaron, Josep C.] Hosp St Joan de Deu, Barcelona 08950, Spain. [Rodriguez-Echevarria, Roberto] Univ Guadalajara, Inst Translat Nutrigenet & Nutrigen, Dept Mol Biol & Genom, CUCS, Guadalajara 44340, Jalisco, Mexico. C3 University of Barcelona; Universidad de Guadalajara RP Jimenez-Chillaron, JC (通讯作者)，Inst Recerca St Joan de Deu, Div Endocrinol, Barcelona 08950, Spain.; Jimenez-Chillaron, JC (通讯作者)，Hosp St Joan de Deu, Barcelona 08950, Spain. EM marcela.parrav@gmail.com; roberto.rodriguez@academico.udg.mx; jjimenezc@fsjd.org RI ; Jimenez-Chillaron, Josep/MBV-2513-2025 OI Roiguez-Echevarria, Roberto/0000-0003-2265-3785; Jimenez-Chillaron, Josep/0000-0002-0648-8049 FU FEDER/Ministerio de Ciencia, Innovacion y Universidades [SAF2017-84542-R]; Instituto de Salud Carlos III [PI14/00035, CPII16/00046]; European Regional Development Plan, "AWay to Make Europe"; Mexico's National Council for Science and Technology (CONACYT), Government of Mexico FX This research was funded by FEDER/Ministerio de Ciencia, Innovacion y Universidades, grant number SAF2017-84542-R; and Instituto de Salud Carlos III, grants PI14/00035; CPII16/00046, co-funded by the European Regional Development Plan, "AWay to Make Europe", to J.C.J.-C. M.P.-V was recipient of a postdoctoral fellowship from the Mexico's National Council for Science and Technology (CONACYT), Government of Mexico. 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(SCI-EXPANDED) SC Nutrition & Dietetics GA PK3NC UT WOS:000602355200001 PM 33348700 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Zelber-Sagi, S Grinshpan, LS Ivancovsky-Wajcman, D Goldenshluger, A Gepner, Y AF Zelber-Sagi, Shira Grinshpan, Laura Sol Ivancovsky-Wajcman, Dana Goldenshluger, Ariela Gepner, Yftach TI One size does not fit all; practical, personal tailoring of the diet to NAFLD patients SO LIVER INTERNATIONAL LA English DT Review DE fatty liver; Mediterranean diet; time-restricted eating; ketogenic diet; low-carb diet; low-fat diet ID FATTY LIVER-DISEASE; LIFE-STYLE MODIFICATION; CALORIE-KETOGENIC DIET; LOW-CARBOHYDRATE DIET; BODY-MASS INDEX; MEDITERRANEAN DIET; WEIGHT-LOSS; HEPATOCELLULAR-CARCINOMA; HEPATIC STEATOSIS; GENETIC-VARIATION AB Different dietary regimens for weight loss have developed over the years. Since the most evidenced treatment for non-alcoholic fatty liver disease (NAFLD) is weight reduction, it is not surprising that more diets targeting obesity are also utilized for NAFLD treatment. However, beyond the desired weight loss effects, one should not ignore the dietary composition of each diet, which may not necessarily be healthy or safe over the long term for hepatic and extrahepatic outcomes, especially cardiometabolic outcomes. Some of these diets are rich in saturated fat and red meat, are very strict, and require close medical supervision. Some may also be very difficult to adhere to for long periods, thus reducing the patient's motivation. The evidence for a direct benefit to NAFLD by restrictive diets such as very-low-carb, ketogenic, very-low-calorie diets, and intermittent fasting is scarce, and the long-term safety has not been tested. Nowadays, the approach is that the diet should be tailored to the patient's cultural and personal preferences. There is strong evidence for the independent protective association of NAFLD with a diet based on healthy eating patterns of minimally-processed foods, low in sugar and saturated fat, high in polyphenols, and healthy types of fats. This leads to the conclusion that a Mediterranean diet should serve as a basis that can be restructured into other kinds of diets. This review will elaborate on the different diets and their role in NAFLD. It will provide a practical guide to tailor the diet to the patients without compromising its composition and safety. C1 [Zelber-Sagi, Shira; Grinshpan, Laura Sol; Ivancovsky-Wajcman, Dana] Univ Haifa, Fac Social Welf & Hlth Sci, Sch Publ Hlth, 199 Aba Khoushy Ave, IL-3498838 Haifa, Israel. [Zelber-Sagi, Shira; Grinshpan, Laura Sol; Ivancovsky-Wajcman, Dana] Tel Aviv Med Ctr & Sch Med, Dept Gastroenterol, Tel Aviv, Israel. [Goldenshluger, Ariela; Gepner, Yftach] Tel Aviv Univ, Sackler Fac Med, Sch Publ Hlth, Dept Epidemiol & Prevent Med, Tel Aviv, Israel. C3 University of Haifa; Tel Aviv University; Sackler Faculty of Medicine; Tel Aviv University; Sackler Faculty of Medicine RP Zelber-Sagi, S (通讯作者)，Univ Haifa, Fac Social Welf & Hlth Sci, Sch Publ Hlth, 199 Aba Khoushy Ave, IL-3498838 Haifa, Israel. 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PD AUG PY 2022 VL 42 IS 8 BP 1731 EP 1750 DI 10.1111/liv.15335 EA JUN 2022 PG 20 WC Gastroenterology & Hepatology WE Science Citation Index Expanded (SCI-EXPANDED) SC Gastroenterology & Hepatology GA 3C4PD UT WOS:000813624500001 PM 35675167 DA 2026-02-02 ER PT J AU Romero-Gómez, M AF Romero-Gomez, Manuel TI Non-alcoholic steatohepatitis SO MEDICINA CLINICA LA English DT Review DE Steatosis; Steatohepatitis; Fibrosis; Cirrhosis; Extrahepatic neoplasms; Cardiovascular disease ID FATTY LIVER-DISEASE; WEIGHT-LOSS; CONTROLLED-TRIAL; SCORING SYSTEM; FIBROSIS; VALIDATION; AGONIST; ADULTS; NAFLD; MRI AB Non-alcoholic steatohepatitis belongs to the spectrum of metabolic-associated fatty liver diseases charac-terized by steatosis linked to obesity, diabetes, metabolic syndrome, dyslipidemia and immune-mediated disorders. The main features of MAFLD include high prevalence, heterogeneity, complexity and dyna-mic disease. Pruritus and asthenia are the main clinical manifestation that impact on quality of life and patient-reported outcomes. Biochemical or imagen-based non-invasive test have been implemented in the diagnostic process. Liver biopsy remains as the gold standard. Therapeutic options included life-style intervention. Mediterranean hypocaloric Diet to lose weight, exercise to fight sarcopenia and alcohol abs-tinence. In non-responders, drug-therapy focusing on obesity, diabetes and fibrosis using sequentially or combined to promote steatosis, inflammation and fibrosis regression.(c) 2022 Published by Elsevier Espana, S.L.U. C1 [Romero-Gomez, Manuel] Univ Seville, Serv Aparato Digest, Ctr Invest Biomed Red Enfermedades Hepat & Digest, Dept Med Hosp,Univ Virgen del Rocio,Inst Biomed S, Seville, Spain. C3 CIBER - Centro de Investigacion Biomedica en Red; CIBEREHD; Consejo Superior de Investigaciones Cientificas (CSIC); University of Sevilla; CSIC-JA-USE - Instituto de Biomedicina de Sevilla (IBIS) RP Romero-Gómez, M (通讯作者)，Univ Seville, Serv Aparato Digest, Ctr Invest Biomed Red Enfermedades Hepat & Digest, Dept Med Hosp,Univ Virgen del Rocio,Inst Biomed S, Seville, Spain. 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Clin. PD OCT 28 PY 2022 VL 159 IS 8 BP 388 EP 395 DI 10.1016/j.medcli.2022.06.017 EA OCT 2022 PG 8 WC Medicine, General & Internal WE Science Citation Index Expanded (SCI-EXPANDED) SC General & Internal Medicine GA 5S6QD UT WOS:000875311000007 PM 36075749 DA 2026-02-02 ER PT J AU Paoli, A Cerullo, G AF Paoli, Antonio Cerullo, Giuseppe TI Investigating the Link between Ketogenic Diet, NAFLD, Mitochondria, and Oxidative Stress: A Narrative Review SO ANTIOXIDANTS LA English DT Review DE ketogenic diet; nonalcoholic fatty liver disease (NAFLD); mitochondria; oxidative stress; liver; ketone bodies ID FATTY LIVER-DISEASE; GROWTH-FACTOR 21; REACTIVE OXYGEN; KETONE-BODIES; INSULIN-RESISTANCE; LOW-CARBOHYDRATE; NONALCOHOLIC STEATOHEPATITIS; CALORIC RESTRICTION; MEDITERRANEAN DIET; HEPATIC STEATOSIS AB Together with the global rise in obesity and metabolic syndrome, the prevalence of individuals who suffer from nonalcoholic fatty liver disease (NAFLD) has risen dramatically. NAFLD is currently the most common chronic liver disease and includes a continuum of liver disorders from initial fat accumulation to nonalcoholic steatohepatitis (NASH), considered the more severe forms, which can evolve in, cirrhosis, and hepatocellular carcinoma. Common features of NAFLD includes altered lipid metabolism mainly linked to mitochondrial dysfunction, which, as a vicious cycle, aggravates oxidative stress and promotes inflammation and, as a consequence, the progressive death of hepatocytes and the severe form of NAFLD. A ketogenic diet (KD), i.e., a diet very low in carbohydrates (<30 g/die) that induces "physiological ketosis", has been demonstrated to alleviate oxidative stress and restore mitochondrial function. Based on this, the aim of the present review is to analyze the body of evidence regarding the potential therapeutic role of KD in NAFLD, focusing on the interplay between mitochondria and the liver, the effects of ketosis on oxidative stress pathways, and the impact of KD on liver and mitochondrial function. C1 [Paoli, Antonio; Cerullo, Giuseppe] Univ Padua, Dept Biomed Sci, I-35131 Padua, Italy. [Paoli, Antonio] UCAM Catholic Univ Murcia, Res Ctr High Performance Sport, Murcia 30107, Spain. C3 University of Padua; Universidad Catolica de Murcia RP Paoli, A (通讯作者)，Univ Padua, Dept Biomed Sci, I-35131 Padua, Italy.; Paoli, A (通讯作者)，UCAM Catholic Univ Murcia, Res Ctr High Performance Sport, Murcia 30107, Spain. 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Green Submitted, gold DA 2026-02-02 ER PT J AU Baratta, F Pastori, D Bartimoccia, S Cammisotto, V Cocomello, N Colantoni, A Nocella, C Carnevale, R Ferro, D Angelico, F Violi, F Del Ben, M AF Baratta, Francesco Pastori, Daniele Bartimoccia, Simona Cammisotto, Vittoria Cocomello, Nicholas Colantoni, Alessandra Nocella, Cristina Carnevale, Roberto Ferro, Domenico Angelico, Francesco Violi, Francesco Del Ben, Maria TI Poor Adherence to Mediterranean Diet and Serum Lipopolysaccharide Are Associated with Oxidative Stress in Patients with Non-Alcoholic Fatty Liver Disease SO NUTRIENTS LA English DT Article DE Non-alcoholic fatty liver disease; Mediterranean diet; oxidative stress; lipopolysaccharide; Nox2-derived peptide ID LOW-GRADE ENDOTOXEMIA; FISH-OIL; PLATELET ACTIVATION; CIRRHOSIS; CONSUMPTION; PARAMETERS; REDUCTION; PREDICT; EVENTS AB Oxidative stress plays a pivotal role in non-alcoholic fatty liver disease (NAFLD). Factors inducing oxidative stress in NAFLD may be several; however, a relationship with the adherence to Mediterranean Diet (Med-diet) and with serum lipopolysaccharide (LPS) has been poorly investigated in this setting. The aim was to investigate factors associated with impaired oxidative stress in NAFLD, focusing on the potential role of LPS and Med-diet. We enrolled 238 consecutive outpatients from the PLINIO study, in whom we measured the soluble Nox2-derived peptide (sNox2-dp), a marker of systemic oxidative stress, and serum LPS. Adherence to Med-diet was investigated by a nine-item validated dietary questionnaire. Serum sNox2-dp and LPS were higher in patients with NAFLD compared to those without (25.0 vs. 9.0 pg/mL,p< 0.001 and 62.0 vs. 44.9 pg/mL,p< 0.001, respectively). In patients with NAFLD, the highest sNox2-dp tertile was associated with the top serum LPS tertile (Odds Ratio (OR): 4.71;p< 0.001), APRI > 0.7 (OR: 6.96;p= 0.005) and Med-diet-score > 6 (OR: 0.14;p= 0.026). Analyzing individual foods, the daily consumption of wine (OR: 0.29,p= 0.046) and the adequate weekly consumption of fish (OR: 0.32,p= 0.030) inversely correlated with the top sNox2-dp tertile. In conclusion, patients with NAFLD showed impaired oxidative stress. Levels of sNox2 correlated with serum LPS and with low adherence to Med-Diet. C1 [Baratta, Francesco; Pastori, Daniele; Bartimoccia, Simona; Cammisotto, Vittoria; Cocomello, Nicholas; Colantoni, Alessandra; Nocella, Cristina; Ferro, Domenico; Violi, Francesco; Del Ben, Maria] Sapienza Univ Rome, Dept Clin Internal Anestesiol & Cardiovasc Sci, Clin Med 1, I-00185 Rome, Italy. [Carnevale, Roberto] Sapienza Univ Rome, Dept Med Surg Sci & Biotechnol, I-04015 Latina, Italy. [Carnevale, Roberto; Violi, Francesco] Mediterranea Cardio Ctr, I-80122 Naples, Italy. [Angelico, Francesco] Sapienza Univ Rome, Dept Publ Hlth & Infect Dis, I-00185 Rome, Italy. C3 Sapienza University Rome; Sapienza University Rome; Sapienza University Rome RP Angelico, F (通讯作者)，Sapienza Univ Rome, Dept Publ Hlth & Infect Dis, I-00185 Rome, Italy. EM francesco.baratta@uniroma1.it; daniele.pastori@uniroma1.it; simona.bartimoccia@uniroma1.it; vittoria.cammisotto@uniroma1.it; nicholas.cocomello@gmail.com; alessandracolantoni@libero.it; cristina.nocella@uniroma1.it; roberto.carnevale@uniroma1.it; domenico.ferro@uniroma1.it; francesco.angelico@uniroma1.it; francesco.violi@uniroma1.it; maria.delben@uniroma1.it RI Bartimoccia, Simona/K-7873-2016; pastori, daniele/J-7087-2016; Carnevale, Roberto/JMC-1138-2023; Cammisotto, Vittoria/W-5910-2019; Nocella, Cristina/K-2175-2016; Del Ben, Maria/AAE-7603-2020; Violi, Francesco/K-1509-2016; ferro, domenico/AAT-5861-2020; Angelico, Francesco/AAB-6585-2020 OI Bartimoccia, Simona/0000-0002-6266-3059; pastori, daniele/0000-0001-6357-5213; Cocomello, Nicholas/0000-0002-4922-4318; Colantoni, Alessana/0000-0003-4330-6379; Baratta, Francesco/0000-0003-1708-272X; Carnevale, Roberto/0000-0002-6216-9595; Cammisotto, Vittoria/0000-0003-1966-5945; FU Progetto Sapienza Ateneo 2019 [RM11916B6C8FB948] FX This research received no external funding - Financed by "Progetto Sapienza Ateneo 2019". prot. 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This large-scale epidemiological study aimed to determine the effect of water-soluble dietary fiber intake on liver fat and fibrosis via gut microbiota for the general population. We divided low- and high-intake groups by median daily water-soluble dietary fiber intake and matched background factors by propensity score matching for sex and age. The high-intake group had lower controlled attenuation parameters, a lower fatty liver index, and a lower mac-2-binding protein glycosylated isomer level than the low-intake group. Furthermore, in the high-intake group, the prevalences of metabolic dysfunction-associated steatotic liver disease and cardiometabolic criteria were significantly lower than in the low-intake group. In the high-intake group, there were increases and decreases in 16 bacterial species. Of them, those belonging to Faecalibacterium and Gemmiger had higher relative abundances than the other species and had a negative correlation with the fatty liver index and its components triglyceride and glutamyl transpeptidase in a multivariate analysis adjusted for confounding factors. On the other hand, Dorea showed a significant negative correlation with liver stiffness measure, even though Dorea was decreased in the high-intake group. Faecalibacterium and Gemmiger are butyrate-producing bacteria, suggesting that water-soluble dietary fiber may inhibit fatty liver via gut butyric acid production. C1 [Sato, Satoshi; Iino, Chikara; Sasada, Takafumi; Soma, Go; Tateda, Tetsuyuki; Furusawa, Keisuke; Yoshida, Kenta; Sakuraba, Hirotake; Fukuda, Shinsaku] Hirosaki Univ, Grad Sch Med, Dept Gastroenterol Hematol & Clin Immunol, 5 Zaifu Cho, Hirosaki, Aomori 0368562, Japan. [Chinda, Daisuke] Hirosaki Univ, Grad Sch Med, Div Endoscopy, 5 Zaifu Cho, Hirosaki, Aomori 0368562, Japan. [Sawada, Kaori; Mikami, Tatsuya; Nakaji, Shigeyuki] Hirosaki Univ, Grad Sch Med, Dept Preempt Med, 5 Zaifu Cho, Hirosaki, Aomori 0368562, Japan. C3 Hirosaki University; Hirosaki University; Hirosaki University RP Sato, S (通讯作者)，Hirosaki Univ, Grad Sch Med, Dept Gastroenterol Hematol & Clin Immunol, 5 Zaifu Cho, Hirosaki, Aomori 0368562, Japan. EM satoshis@hirosaki-u.ac.jp RI Yoshida, Kenta/MCJ-0506-2025; Chinda, Daisuke/X-1288-2019; Soma, Go/JJC-8644-2023; Iino, Chikara/I-8730-2019 FU JST COI [JPMJCE1302, PPMJCA2201, JPMJP2210]; Grants-in-Aid for Scientific Research [21K10437, 23K07451, 22K17386] Funding Source: KAKEN FX We gratefully acknowledge the work of the past and present members of our laboratory. This work was supported by the JST COI Grant Numbers JPMJCE1302, PPMJCA2201, and JPMJP2210. 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Microbiota Food Health PY 2025 VL 44 IS 1 BP 49 EP 57 DI 10.12938/bmfh.2024-046 PG 9 WC Microbiology; Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Microbiology; Nutrition & Dietetics GA R3G3Q UT WOS:001390371200007 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Romero-Gómez, M Zelber-Sagi, S Trenell, M AF Romero-Gomez, Manuel Zelber-Sagi, Shira Trenell, Michael TI Treatment of NAFLD with diet, physical activity and exercise SO JOURNAL OF HEPATOLOGY LA English DT Review DE Mediterranean diet; Steatosis; Steatohepatitis; Fibrosis; Physical activity; Exercise; Weight loss; Behaviour intervention ID NONALCOHOLIC FATTY LIVER; LIFE-STYLE INTERVENTION; GLYCATION END-PRODUCTS; CARDIOVASCULAR RISK-FACTORS; MODEST ALCOHOL-CONSUMPTION; PNPLA3 GENE POLYMORPHISM; VITAMIN-D STATUS; URIC-ACID LEVEL; WEIGHT-LOSS; INSULIN-RESISTANCE AB Lifestyle intervention can be effective when treating non-alcoholic fatty liver diseases (NAFLD) patients. Weight loss decreases cardiovascular and diabetes risk and can also regress liver disease. Weight reductions of >= 10% can induce a near universal non-alcoholic steatohepatitis resolution and fibrosis improvement by at least one stage. However, modest weight loss (>5%) can also produce important benefits on the components of the NAFLD activity score (NAS). Additionally, we need to explore the role of total calories and type of weight loss diet, micro-and macronutrients, evidence-based benefits of physical activity and exercise and finally support these modifications through established behavioural change models and techniques for long-term maintenance of lifestyle modifications. Following a Mediterranean diet can reduce liver fat even without weight loss and is the most recommended dietary pattern for NAFLD. The Mediterranean diet is characterised by reduced carbohydrate intake, especially sugars and refined carbohydrates (40% of the calories vs. 5060% in a typical low fat diet), and increased monounsaturated and omega-3 fatty acid intake (40% of the calories as fat vs. up-to 30% in a typical low fat diet). Both TV sitting (a reliable marker of overall sedentary behaviour) and physical activity are associated with cardiometabolic health, NAFLD and overall mortality. A 'triple hit behavioural phenotype' of: i) sedentary behaviour, ii) low physical activity, and iii) poor diet have been defined. Clinical evidence strongly supports the role of lifestyle modification as a primary therapy for the management of NAFLD and NASH. This should be accompanied by the implementation of strategies to avoid relapse and weight regain. (C) 2017 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved. C1 [Romero-Gomez, Manuel] Univ Seville, Inst Biomed Seville, Univ Hosp Virgen del Rocio, Mac Ro UCM IC Digest Dis, Seville, Spain. [Romero-Gomez, Manuel] Univ Seville, Inst Biomed Seville, Univ Hosp Virgen del Rocio, Ciberehd, Seville, Spain. [Zelber-Sagi, Shira] Tel Aviv Med Ctr & Sch Med, Dept Gastroenterol, Tel Aviv, Israel. [Zelber-Sagi, Shira] Univ Haifa, Sch Publ Hlth, Fac Social Welf & Hlth Sci, Haifa, Israel. [Trenell, Michael] Newcastle Univ, NIHR Innovat Observ, Newcastle Upon Tyne, Tyne & Wear, England. C3 Virgen del Rocio University Hospital; Consejo Superior de Investigaciones Cientificas (CSIC); University of Sevilla; CSIC-JA-USE - Instituto de Biomedicina de Sevilla (IBIS); Consejo Superior de Investigaciones Cientificas (CSIC); University of Sevilla; CSIC-JA-USE - Instituto de Biomedicina de Sevilla (IBIS); Virgen del Rocio University Hospital; CIBER - Centro de Investigacion Biomedica en Red; CIBEREHD; Tel Aviv University; Sackler Faculty of Medicine; University of Haifa; Newcastle University - UK RP Romero-Gómez, M (通讯作者)，Virgen del Rocio Univ Hosp, Mac Ro UCM Digest Dis, Ave Manuel Siurot S-N, Seville 41013, Spain. EM mromerogome-z@us.es RI ; Romero-Gómez, Manuel/L-8030-2014 OI Trenell, Michael/0000-0001-8253-5620; Romero-Gómez, Manuel/0000-0001-8494-8947 FU Instituto de Salud Carlos III, MINECO, Spain [PI 16/ 01842]; ESRC [ES/K007688/1] Funding Source: UKRI; MRC [G0700718, MR/L016354/1] Funding Source: UKRI; Economic and Social Research Council [ES/K007688/1] Funding Source: researchfish; Medical Research Council [MR/L016354/1, G0700718] Funding Source: researchfish FX PI 16/ 01842 Instituto de Salud Carlos III, MINECO, Spain. 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Hepatol. PD OCT PY 2017 VL 67 IS 4 BP 829 EP 846 PG 18 WC Gastroenterology & Hepatology WE Science Citation Index Expanded (SCI-EXPANDED) SC Gastroenterology & Hepatology GA FG9RE UT WOS:000410775900020 PM 28545937 OA Green Submitted HC Y HP N DA 2026-02-02 ER PT J AU Cano, R Bermúdez, V Galban, N Garrido, B Santeliz, R Gotera, MP Duran, P Boscan, A Carbonell-Zabaleta, AK Duran-Agüero, S Rojas-Gómez, D González-Casanova, J Díaz-Vásquez, W Chacín, M Dávila, LA AF Cano, Raquel Bermudez, Valmore Galban, Nestor Garrido, Bermary Santeliz, Raquel Gotera, Maria Paula Duran, Pablo Boscan, Arturo Carbonell-Zabaleta, Ana-Karina Duran-Aguero, Samuel Rojas-Gomez, Diana Gonzalez-Casanova, Jorge Diaz-Vasquez, Waldo Chacin, Maricarmen Angarita Davila, Lisse TI Dietary Polyphenols and Gut Microbiota Cross-Talk: Molecular and Therapeutic Perspectives for Cardiometabolic Disease: A Narrative Review SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES LA English DT Review DE gut microbiota; polyphenols; flavonoids; diabetes mellitus; steatotic liver disease; cardiovascular disease ID FATTY LIVER-DISEASE; CARDIOVASCULAR RISK-FACTORS; RESVERATROL SUPPLEMENTATION; DOUBLE-BLIND; MEDITERRANEAN DIET; WINE POLYPHENOLS; QUERCETIN; DEGRADATION; MODULATION; NEUROPROTECTION AB The intricate interplay between the gut microbiota and polyphenols has emerged as a captivating frontier in understanding and potentially harnessing the therapeutic potential of these bioactive compounds. Phenolic compounds, renowned for their antioxidant, anti-inflammatory, antidiabetic, and anticancer properties, are subject to intricate transformations within the gut milieu, where the diverse microbial ecosystem exerts profound effects on their metabolism and bioavailability. Conversely, polyphenols exhibit a remarkable capacity to modulate the composition and activity of the gut microbiota, fostering a bidirectional relationship that extends beyond mere nutrient processing. This symbiotic interaction holds significant implications for human health, particularly in cardiometabolic diseases such as diabetes mellitus, metabolic-dysfunction-associated steatotic liver disease, and cardiovascular disease. Through a comprehensive exploration of molecular interactions, this narrative review elucidates the reciprocal dynamics between the gut microbiota and polyphenols, unveiling novel avenues for therapeutic intervention in cardiometabolic disorders. By unravelling the intricate cross-talk between these two entities, this review underscores the multifaceted roles of polyphenols in overall health and the pivotal role of gut microbiota modulation as a promising therapeutic strategy in mitigating the burden of cardiometabolic diseases. C1 [Cano, Raquel; Galban, Nestor; Garrido, Bermary; Santeliz, Raquel; Gotera, Maria Paula; Duran, Pablo] Univ Zulia, Escuela Med, Ctr Invest Endocrino Metab, Maracaibo 4001, Venezuela. [Bermudez, Valmore; Carbonell-Zabaleta, Ana-Karina; Chacin, Maricarmen] Univ Simon Bolivar, Fac Ciencias Salud, Barranquilla 080002, Colombia. [Boscan, Arturo] Univ Zulia, Escuela Med, Fac Med, Maracaibo 4001, Venezuela. [Duran-Aguero, Samuel; Diaz-Vasquez, Waldo] Univ San Sebastian, Escuela Nutr & Dietet, Fac Ciencias Cuidado Salud, Santiago 7511111, Chile. [Rojas-Gomez, Diana] Univ Andres Bello, Escuela Nutr & Dietet, Fac Med, Santiago 8370321, Chile. [Gonzalez-Casanova, Jorge] Univ Autonoma Chile, Fac Ciencias Salud, Inst Ciencias Biomed, Santiago 8910060, Chile. [Angarita Davila, Lisse] Univ Andres Bello, Escuela Nutr & Dietet, Fac Med, Concepcion 4260000, Chile. C3 Universidad San Sebastian; Universidad Andres Bello; Universidad Autonoma de Chile; Universidad Andres Bello RP Dávila, LA (通讯作者)，Univ Andres Bello, Escuela Nutr & Dietet, Fac Med, Concepcion 4260000, Chile. EM raquelamiracano@gmail.com; nestorag17@gmail.com; gabrielasanteliz29@gmail.com; pabloduran1998@gmail.com; arturojboscanmd@gmail.com; diana.rojas@unab.cl; lisse.angarita@unab.cl RI Agüero, Samuel/AAZ-6140-2020; Duran, Pablo/AAW-6866-2020; Bermudez, Valmore/HLH-6291-2023; Boscan Gonzalez, Arturo Jose/JXL-9205-2024 OI Carbonell Zabaleta, Ana Karina/0009-0001-3690-9721; Santeliz, Raquel/0000-0003-0761-5879; Díaz Vásquez, Waldo/0000-0002-3473-7540; Galban, Nestor/0000-0003-0765-2290; Chacín, Maricarmen/0000-0002-5208-9401; Duran, Pablo/0000-0002-8030-1780; Garrido, Bermary/0000-0002-5522-7697; Angarita, Lisse/0000-0001-7860-5112; Bermudez, Valmore/0000-0003-1880-8887; Rojas-Gomez, Diana Marcela/0000-0002-6956-6315; Boscan Gonzalez, Arturo Jose/0009-0001-1930-2776; Cano, Raquel/0000-0002-3692-9917 FU Universidad Andres Bello FX This article received funding from Universidad Andres Bello. 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J. Mol. Sci. PD AUG PY 2024 VL 25 IS 16 AR 9118 DI 10.3390/ijms25169118 PG 26 WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary WE Science Citation Index Expanded (SCI-EXPANDED) SC Biochemistry & Molecular Biology; Chemistry GA E8E3U UT WOS:001305275100001 PM 39201807 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Mao, TY Sun, YW Xu, XY He, K AF Mao, Tianyu Sun, Yiwen Xu, Xinyi He, Kang TI Overview and prospect of NAFLD: Significant roles of nutrients and dietary patterns in its progression or prevention SO HEPATOLOGY COMMUNICATIONS LA English DT Review ID FATTY LIVER-DISEASE; IMPROVES HEPATIC STEATOSIS; STOP HYPERTENSION DASH; NONALCOHOLIC STEATOHEPATITIS; WEIGHT-LOSS; AMINO-ACIDS; VITAMIN-E; INSULIN SENSITIVITY; MEDITERRANEAN DIET; METABOLIC SYNDROME AB NAFLD is the most common chronic liver disease worldwide, characterized by lipid accumulation in the liver, and usually evolves from steatohepatitis to fibrosis, cirrhosis, or even HCC. Its incidence is rapidly rising in parallel with the increasing prevalence of obesity and metabolic syndrome. Current therapies are limited to lifestyle changes including dietary intervention and exercise, in which dietary modification exerts an important part in losing weight and preventing NAFLD. In this review, we briefly discuss the roles and mechanisms of dietary components including fructose, non-nutritive sweeteners, fat, proteins, and vitamins in the progression or prevention of NAFLD. We also summarize several popular dietary patterns such as calorie-restricted diets, intermittent fasting, ketogenic diets, Mediterranean diets, and dietary approach to stop hypertension diets and compare the effects of low-fat and low-carbohydrate diets in preventing the development of NAFLD. Moreover, we summarize the potential drugs targeting metabolic-related targets in NAFLD. C1 [Mao, Tianyu; Sun, Yiwen; Xu, Xinyi; He, Kang] Shanghai Jiao Tong Univ, Renji Hosp, Sch Med, Dept Liver Surg, Shanghai, Peoples R China. [Mao, Tianyu; Sun, Yiwen; Xu, Xinyi; He, Kang] Shanghai Engn Res Ctr Transplantat & Immunol, Shanghai, Peoples R China. [Mao, Tianyu; Sun, Yiwen; Xu, Xinyi; He, Kang] Shanghai Inst Transplantat, Shanghai, Peoples R China. [He, Kang] 1630 Dongfang Rd, Shanghai 200127, Peoples R China. C3 Shanghai Jiao Tong University RP He, K (通讯作者)，1630 Dongfang Rd, Shanghai 200127, Peoples R China. EM susanmao1@sjtu.edu.cn; sun_777@sjtu.edu.cn; xxy1219@sjtu.edu.cn; hekang929@163.com RI ; 何, 康/IWE-0733-2023 OI sun, yiwen/0009-0002-0764-6819; FU Project of the Shanghai Municipal Health Commission [20204Y0012]; Seed Fund of Renji Hospital [RJZZ18-010]; Shenkang 3-year action plan [SHDC2020CR2003A, SHDC2020CR5012]; Innovative Research Team of High-Level Local Universities in Shanghai [SSMU-ZDCX20180802]; National Natural Science Foundation of China [81972205]; Project of Shanghai key clinical specialties [shslczdzk05801] FX This study was supported by the Project of the Shanghai Municipal Health Commission (20204Y0012), Seed Fund of Renji Hospital (RJZZ18-010), Shenkang 3-year action plan (SHDC2020CR2003A, SHDC2020CR5012),Innovative Research Team of High-Level Local Universities in Shanghai (SSMU-ZDCX20180802), National Natural Science Foundation of China (81972205), and the Project of Shanghai key clinical specialties (shslczdzk05801). 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Commun. PD OCT PY 2023 VL 7 IS 10 AR e0234 DI 10.1097/HC9.0000000000000234 PG 41 WC Gastroenterology & Hepatology WE Science Citation Index Expanded (SCI-EXPANDED) SC Gastroenterology & Hepatology GA S6WO3 UT WOS:001072552700001 PM 37756016 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Trovato, GM Martines, GF Pirri, C Trovato, FM Castro, A Garozzo, A Catalano, D AF Trovato, Guglielmo M. Martines, Giuseppe Fabio Pirri, Clara Trovato, Francesca M. Castro, Angelo Garozzo, Adriana Catalano, Daniela TI Obesity-independent Association of Human Adenovirus Ad37 Seropositivity With Nonalcoholic Fatty Liver Disease SO JOURNAL OF CLINICAL GASTROENTEROLOGY LA English DT Article DE adenovirus Ad37; obesity; bright liver; fatty liver; NAFLD; liver steatosis; insulin resistance; HOMA; Mediterranean diet ID INCREASED INTESTINAL PERMEABILITY; INSULIN-RESISTANCE; PHYSICAL-ACTIVITY; BRIGHT LIVER; HEPATITIS-C; WEIGHT-LOSS; STEATOSIS; STEATOHEPATITIS; OVERWEIGHT; ABNORMALITIES AB Objective: Adenoviruses Ad36 and Ad37 increase adiposity in animals and are associated with obesity in humans; effects on the liver have been reported. The association of Adenovirus Ad36 seropositivity (Ad36+) with obesity but not with the severity of nonalcoholic fatty liver disease (NAFLD) has been previously shown. We investigate whether nondiabetic Ad37+ patients show a different prevalence of NAFLD and ultrasound Bright Liver score. Patients: A total of 268 adult nondiabetic patients (146 men, 122 women) were included after lifestyle counseling including a personalized Mediterranean diet, increase in physical activity, and smoking withdrawal. After an Ad37+/Ad36+ assay, overweight obesity, insulin resistance, C-reactive protein, and bright liver prevalence and severity were compared according to Ad37+. Results: Sixty-five of 268 patients were Ad37+ and 82/268 patients were both Ad37 seronegative (Ad37-) and Ad36-. The prevalence of obesity, defined as body mass index >= 30, was not significantly different in Ad37+ (11/65; 16.9%) vs. Ad37- (15/82; 18.2%) patients; Bright Liver was present in 22/65 (33.8%) Ad37+ patients vs. 13/82 (15.8%) Ad37- patients (P < 0.019). By odds ratio (OR), a consistent risk for NAFLD was associated with Ad37+, greater insulin resistance, and C-reactive protein. By a predictive multiple linear regression model, 40.0% of variance toward NAFLD and 50.4% toward the severity of Bright Liver score was explained significantly and independently by Ad37+ and by body mass index. Conclusions: Ad37+ status in nondiabetic patients on an appropriate diet is significantly associated with NAFLD; because fatty liver improves even without weight loss by a "healthy" diet, and not only by lower food caloric intake, Ad37+ may be an adjunctive hallmark of an unfavorable clinical-metabolic profile, if not a causative factor of NAFLD. C1 [Trovato, Guglielmo M.] Univ Catania, Ist Med Interna, Unita Diagnost & Terapia Med, Dept Internal Med Diagnost & Terapia Med,Fac Med, I-95131 Catania, Italy. [Castro, Angelo; Garozzo, Adriana] Univ Catania, Fac Med & Chirurg, Dept Biomed Sci, I-95131 Catania, Italy. C3 University of Catania; University of Catania RP Trovato, GM (通讯作者)，Univ Catania, Ist Med Interna, Unita Diagnost & Terapia Med, Dept Internal Med Diagnost & Terapia Med,Fac Med, Via St Orsola 30, I-95131 Catania, Italy. EM guglielmotrovato@unict.it RI ; Catalano, Daniela/J-2883-2012; Castro, Angelo/JTT-7024-2023; GAROZZO, AIANA/F-2855-2012 OI Trovato, Guglielmo M/0000-0002-1168-1919; GAROZZO, AIANA/0000-0001-8908-2185; Trovato, Francesca Maria/0000-0002-8048-1646 CR Abonyo BO, 2005, AM J PHYSIOL-LUNG C, V289, pL478, DOI 10.1152/ajplung.00032.2005 Atkinson RL, 2005, INT J OBESITY, V29, P281, DOI 10.1038/sj.ijo.0802830 Broderick MP, 2010, INT J OBESITY, V34, P302, DOI 10.1038/ijo.2009.224 Brun P, 2007, AM J PHYSIOL-GASTR L, V292, pG518, DOI 10.1152/ajpgi.00024.2006 Catalano D, 2008, LIVER INT, V28, P1280, DOI 10.1111/j.1478-3231.2008.01742.x Clark JM, 2006, J CLIN GASTROENTEROL, V40, pS39 Cohen DA, 2008, INT J OBESITY, V32, pS137, DOI 10.1038/ijo.2008.250 De Bruyne RML, 2010, HEPATOL INT, V4, P375, DOI 10.1007/s12072-009-9160-z Due P, 2009, INT J OBESITY, V33, P1084, DOI 10.1038/ijo.2009.128 Floch MH, 2010, J CLIN GASTROENTEROL, V44, pS19, DOI 10.1097/MCG.0b013e3181dd4fb7 Gonzalez-Mariscal L, 2009, FRONT BIOSCI-LANDMRK, V14, P731, DOI 10.2741/3276 Grafova IB, 2008, AM J PUBLIC HEALTH, V98, P2065, DOI 10.2105/AJPH.2007.127712 Guttman JA, 2009, BBA-BIOMEMBRANES, V1788, P832, DOI 10.1016/j.bbamem.2008.10.028 Jacobs M, 2011, METABOLISM, V60, P969, DOI 10.1016/j.metabol.2010.09.006 Leskinen T, 2009, INT J OBESITY, V33, P1211, DOI 10.1038/ijo.2009.170 Levin BE, 2009, INT J OBESITY, V33, pS53, DOI 10.1038/ijo.2009.18 Lin G, 2007, OBESITY, V15, P2120, DOI 10.1038/oby.2007.252 Malik R, 2009, J GASTROEN HEPATOL, V24, P564, DOI 10.1111/j.1440-1746.2008.05731.x Mathiesen UL, 2002, DIGEST LIVER DIS, V34, P516, DOI 10.1016/S1590-8658(02)80111-6 MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883 Miele L, 2009, HEPATOLOGY, V49, P1877, DOI 10.1002/hep.22848 Mitra AK, 2010, OBES REV, V11, P289, DOI 10.1111/j.1467-789X.2009.00677.x Mustelin L, 2009, INT J OBESITY, V33, P29, DOI 10.1038/ijo.2008.258 Na HN, 2010, INT J OBESITY, V34, P89, DOI 10.1038/ijo.2009.207 Negro F, 2009, LIVER INT, V29, P26, DOI 10.1111/j.1478-3231.2008.01950.x O'Rahilly S, 2008, INT J OBESITY, V32, pS55, DOI 10.1038/ijo.2008.239 Palmentieri B, 2006, DIGEST LIVER DIS, V38, P485, DOI 10.1016/j.dld.2006.03.021 Patel AA, 2009, J CLIN GASTROENTEROL, V43, P970, DOI 10.1097/MCG.0b013e3181b57475 Rathod M, 2007, INT J OBESITY, V31, P78, DOI 10.1038/sj.ijo.0803358 Ratziu V, 2005, GASTROENTEROLOGY, V128, P1898, DOI 10.1053/j.gastro.2005.03.084 Riquelme A, 2009, LIVER INT, V29, P82, DOI 10.1111/j.1478-3231.2008.01823.x Robinson SM, 2008, INT J OBESITY, V32, pS4, DOI 10.1038/ijo.2008.201 Robinson SM, 2009, INT J OBES LOND S6, V32, pS4 Rothenberg M, 2009, DIGEST DIS SCI, V54, P218, DOI 10.1007/s10620-008-0628-9 Saadeh S, 2002, GASTROENTEROLOGY, V123, P745, DOI 10.1053/gast.2002.35354 Schreuder TCMA, 2010, AM J PHYSIOL-GASTR L, V298, pG440, DOI 10.1152/ajpgi.00322.2009 Sherry B, 2005, INT J OBESITY, V29, pS116, DOI 10.1038/sj.ijo.0803078 Suplicy HD, 2009, ARQ BRAS ENDOCRINOL, V53, P159, DOI 10.1590/S0004-27302009000200007 Trichopoulou A, 2003, NEW ENGL J MED, V348, P2599, DOI 10.1056/NEJMoa025039 Trovato GM, 2009, INT J OBESITY, V33, P1402, DOI 10.1038/ijo.2009.196 Trovato GM, 2001, DIABETES NUTR METAB, V14, P325 Trovato GM, 2010, LIVER INT, V30, P184, DOI 10.1111/j.1478-3231.2009.02127.x van Ginneken V, 2009, MED HYPOTHESES, V72, P383, DOI 10.1016/j.mehy.2008.11.034 Vangipuram SD, 2007, INT J OBESITY, V31, P87, DOI 10.1038/sj.ijo.0803366 Verdam FJ, 2011, J CLIN GASTROENTEROL, V45, P149, DOI 10.1097/MCG.0b013e3181e12c24 Vijay-Kumar M, 2010, SCIENCE, V328, P228, DOI 10.1126/science.1179721 Waye MMY, 2011, FREE RADICAL RES, V45, P880, DOI 10.3109/10715762.2011.571684 Whigham LD, 2006, AM J PHYSIOL-REG I, V290, pR190, DOI 10.1152/ajpregu.00479.2005 Yamashiki N, 2009, TRANSPLANTATION, V88, P575, DOI 10.1097/TP.0b013e3181b11c19 Yki-Järvinen H, 2005, ANN MED, V37, P347, DOI 10.1080/07853890510037383 Younossi ZM, 2004, J CLIN GASTROENTEROL, V38, P705, DOI 10.1097/01.mcg.0000135372.10846.2a NR 51 TC 16 Z9 18 U1 0 U2 5 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA SN 0192-0790 J9 J CLIN GASTROENTEROL JI J. Clin. Gastroenterol. PD JUL PY 2012 VL 46 IS 6 BP E46 EP E54 DI 10.1097/MCG.0b013e31824b225c PG 9 WC Gastroenterology & Hepatology WE Science Citation Index Expanded (SCI-EXPANDED) SC Gastroenterology & Hepatology GA 959RW UT WOS:000305331500001 PM 22476041 DA 2026-02-02 ER PT J AU Sun, LQ Chen, HJ Ou, Q Liang, XP Wu, QM Yu, XX Zhao, HQ Huang, QL Yi, ZH Tan, XY Wei, J Wu, F Zhu, HL Wang, LJ AF Sun, Liuqiao Chen, Hangjun Ou, Qian Liang, Xiaoping Wu, Qiongmei Yu, Xinxue Zhao, Hanqing Huang, Qiaoli Yi, Zehua Tan, Xuying Wei, Jun Wu, Feng Zhu, Huilian Wang, Lijun TI The effects of nutritional interventions in patients with non-alcoholic fatty liver disease: An umbrella review of meta-analyses of randomized controlled trials SO TRENDS IN FOOD SCIENCE & TECHNOLOGY LA English DT Review DE Non-alcoholic fatty liver disease; Nutritional interventions; Umbrella review ID INTERNATIONAL SCIENTIFIC ASSOCIATION; VITAMIN-D DEFICIENCY; CONSENSUS STATEMENT; MEDITERRANEAN DIET; OXIDATIVE STRESS; SUPPLEMENTATION; MANAGEMENT; DEFINITION; PROBIOTICS; PREBIOTICS AB Background: Currently, there are no recognized interventions for the prevention and treatment of non-alcoholic fatty liver disease (NAFLD). Systematic reviews and meta-analyses of the relationship between nutritional interventions and NAFLD have yielded contradictory findings. Scope and approach: An umbrella review was conducted to assess the relationship between various nutritional intervention strategies and NAFLD. The AMSTAR 2 and GRADE were used to assess methodological quality and evidence quality. Key findings: The study examined 30 articles reporting 167 unique meta-analyses, covering 14 nutritional factors and 22 outcomes. In patients with NAFLD, moderate-quality evidence suggested that vitamin E supplementation decreased the steatosis score (WMD = -0.61, 95% CI: -0.89, -0.34), hepatocellular ballooning score (WMD = -0.32, 95% CI: -0.53, -0.10), and lobular inflammation score (WMD = -0.31, 95% CI: -0.52, -0.10). Supplementation of omega-3 polyunsaturated fatty acid (omega-3 PUFA) (RR = 1.52, 95% CI: 1.09, 2.13) and curcumin (RR = 3.96, 95% CI: 1.54, 10.17) presented greater improvement in liver steatosis in people with NAFLD, the quality evidence was moderate. In addition, moderate- to high-quality evidence showed that supplementation of vitamin D, vitamin E, omega-3 PUFA, probiotics, prebiotics, synbiotics, green tea exact, curcumin, Mediterranean diet, soy diet, and ginger improved anthropometric and biochemical indicators to some extent. Conclusion: Vitamin E, omega-3 PUFA, and curcumin have convinced evidence to improve the prognosis for patients with NAFLD. More studies are needed to explore the impact of vitamin D, probiotics, prebiotics, synbiotics, green tea exact, Mediterranean diet, soy diet, and ginger on NAFLD. C1 [Sun, Liuqiao] Jinan Univ, Sch Med, Dept Maternal Child & Adolescent Hlth, Guangzhou 510632, Peoples R China. [Chen, Hangjun; Ou, Qian; Liang, Xiaoping; Wu, Qiongmei; Yu, Xinxue; Zhao, Hanqing; Huang, Qiaoli; Yi, Zehua; Wang, Lijun] Jinan Univ, Sch Med, Dept Nutr, Guangzhou 510632, Peoples R China. [Tan, Xuying] Guangzhou Med Univ, Guangzhou Women & Childrens Med Ctr, Guangdong Prov Clin Res Ctr Child Hlth, Dept Children Hlth Care, Guangzhou 510623, Peoples R China. [Wei, Jun; Wu, Feng] Guangzhou Customs, Dept Sci & Technol, Guangzhou 510623, Peoples R China. [Zhu, Huilian] Sun Yat Sen Univ, Sch Publ Hlth, Dept Nutr, Guangzhou 510080, Peoples R China. [Wang, Lijun] Jinan Univ, Sch Med, 601 Huangpu Rd West, Guangzhou 510632, Peoples R China. C3 Jinan University; Jinan University; Guangzhou Medical University; Sun Yat Sen University; Jinan University RP Wang, LJ (通讯作者)，Jinan Univ, Sch Med, 601 Huangpu Rd West, Guangzhou 510632, Peoples R China. EM tswanglj5@jnu.edu.cn RI Zhu, Huilian/V-1040-2019 FU Guangdong Basic and Applied Basic Research Foundation [2023A1515030168]; Scientific research fund of China Nutrition Society [CNS-HPNK2021-44] FX Funding This research was funded by Guangdong Basic and Applied Basic Research Foundation (Grant number: 2023A1515030168) and Scientific research fund of China Nutrition Society (Grant number: CNS-HPNK2021-44) . 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Technol. PD NOV PY 2023 VL 141 AR 104138 DI 10.1016/j.tifs.2023.104138 EA OCT 2023 PG 11 WC Food Science & Technology WE Science Citation Index Expanded (SCI-EXPANDED) SC Food Science & Technology GA X9JI6 UT WOS:001101527600001 DA 2026-02-02 ER PT J AU George, ES Forsyth, AK Reddy, A Itsiopoulos, C Roberts, SK Nicoll, AJ Ryan, MC Tierney, AC AF George, Elena S. Forsyth, Adrienne K. Reddy, Anjana Itsiopoulos, Catherine Roberts, Stuart K. Nicoll, Amanda J. Ryan, Marno C. Tierney, Audrey C. TI A Mediterranean and low-fat dietary intervention in non-alcoholic fatty liver disease patients: Exploring participant experience and perceptions about dietary change SO JOURNAL OF HUMAN NUTRITION AND DIETETICS LA English DT Article DE Australia; diet; low fat diet; Mediterranean diet; non-alcoholic fatty liver disease; perception ID BARRIERS; FACILITATORS; ADHERENCE; FRUIT AB Background A Mediterranean diet (MD) appears to be beneficial in non-alcoholic fatty liver disease (NAFLD) patients in Mediterranean countries; however, the acceptability of a MD in non-Mediterranean populations has not been thoroughly explored. The present study aimed to explore the acceptability through understanding the barriers and enablers of the MD and low-fat diet (LFD) interventions as perceived by participating Australian adults from multicultural backgrounds with NAFLD. Methods Semi-structured telephone interviews were performed with 23 NAFLD trial participants at the end of a 12-week dietary intervention in a multicentre, parallel, randomised clinical trial. Data were analysed using thematic analysis. Results Participants reported that they enjoyed taking part in the MD and LFD interventions and perceived that they had positive health benefits from their participation. Compared with the LFD, the MD group placed greater emphasis on enjoyment and intention to maintain dietary changes. Novelty, convenience and the ability to swap food/meals were key enablers for the successful implementation for both of the dietary interventions. Flavour and enjoyment of food, expressed more prominently by MD intervention participants, were fundamental components of the diets with regard to reported adherence and intention to maintain dietary change. Conclusions Participants randomised to the MD reported greater acceptability of the diet than those randomised to the LFD, predominantly related to perceived novelty and palatability of the diet. C1 [George, Elena S.; Reddy, Anjana] Deakin Univ, Sch Exercise & Nutr Sci, Inst Phys Act & Nutr, Geelong, Vic 3217, Australia. [George, Elena S.; Forsyth, Adrienne K.; Tierney, Audrey C.] La Trobe Univ, Sch Allied Hlth Human Serv & Sport, Bundoora, Vic, Australia. [Forsyth, Adrienne K.] Australian Catholic Univ, Sch Behav & Hlth Sci, Melbourne, Vic, Australia. [Itsiopoulos, Catherine] RMIT Univ, Sch Hlth & Biomed Sci, Bundoora, Vic, Australia. [Roberts, Stuart K.] Alfred Hlth, Gastroenterol Dept, Prahran, Vic, Australia. [Nicoll, Amanda J.] Eastern Hlth, Gastroenterol Dept, Box Hill, Vic, Australia. [Ryan, Marno C.] St Vincents Hosp, Gastroenterol Dept, Darlinghurst, NSW, Australia. [Tierney, Audrey C.] Univ Limerick, Sch Allied Hlth, Hlth Res Inst, Hlth Implementat Sci & Technol Res Grp, Limerick, Ireland. [Roberts, Stuart K.] Monash Univ, Cent Clin Sch, Melbourne, Vic, Australia. C3 Deakin University; La Trobe University; Australian Catholic University; Royal Melbourne Institute of Technology (RMIT); Alfred Health; Eastern Health; NSW Health; St Vincents Hospital Sydney; University of Limerick; Monash University RP George, ES (通讯作者)，Deakin Univ, Sch Exercise & Nutr Sci, Inst Phys Act & Nutr, Geelong, Vic 3217, Australia. EM elena.george@deakin.edu.au RI Forsyth, Aienne/ISB-2103-2023; Tierney, Audrey/AAB-7068-2022; George, Elena/J-3357-2019 OI Forsyth, Aienne/0000-0002-1692-2638; Reddy, Anj/0009-0007-3332-8597; George, Elena/0000-0002-1385-2371; Roberts, Stuart/0000-0002-9015-7997 FU La Trobe University Understanding Disease grant FX The overarching study was funded by a La Trobe University Understanding Disease grant CR Ammerman AS, 2002, PREV MED, V35, P25, DOI 10.1006/pmed.2002.1028 Atkins L, 2017, IMPLEMENT SCI, V12, DOI 10.1186/s13012-017-0605-9 Bach-Faig A, 2011, PUBLIC HEALTH NUTR, V14, P2274, DOI 10.1017/S1368980011002515 Bemelmans WJE, 2004, EUR J PUBLIC HEALTH, V14, P240, DOI 10.1093/eurpub/14.3.240 Desroches Sophie, 2013, Cochrane Database Syst Rev, pCD008722, DOI 10.1002/14651858.CD008722.pub2 Erwin CM, 2018, BMC PUBLIC HEALTH, V18, DOI 10.1186/s12889-018-5078-5 Gellar LA, 2007, DIABETES EDUCATOR, V33, P671, DOI 10.1177/0145721707303807 George ES, 2022, LIVER INT, V42, P1308, DOI 10.1111/liv.15264 George ES, 2018, NUTRIENTS, V10, DOI 10.3390/nu10040465 Glanz K, 1998, J AM DIET ASSOC, V98, P1118, DOI 10.1016/S0002-8223(98)00260-0 GLANZ K, 1994, HEALTH EDUC QUART, V21, P499, DOI 10.1177/109019819402100412 Hagfors Linda, 2005, Nutr Metab (Lond), V2, P26, DOI 10.1186/1743-7075-2-26 Han JK, 2023, ACS APPL MATER INTER, V15, P5449, DOI 10.1021/acsami.2c19208 Kelly S, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0145074 KRISTAL AR, 1995, PREV MED, V24, P221, DOI 10.1006/pmed.1995.1037 Mayr HL, 2022, J ACAD NUTR DIET, V122, P1263, DOI 10.1016/j.jand.2022.01.012 Mayring P., 2000, Forum Qualitative Sozialforschung / Forum: Qualitative Social Research, V1, DOI [DOI 10.1111/J.1365-2648.2007.04569.X, 10.1177/2158244014522633, DOI 10.17169/FQS-1.2.1089] Middleton G, 2015, J NUTR HEALTH AGING, V19, P1019, DOI [10.1007/s12603-015-0663-0, 10.1007/s12603-015-0522-z] Moore SE, 2018, J HUM NUTR DIET, V31, P451, DOI 10.1111/jhn.12523 Nicklas TA, 2013, J ACAD NUTR DIET, V113, P1317, DOI 10.1016/j.jand.2013.05.004 Opie RS, 2018, NUTR NEUROSCI, V21, P487, DOI [10.1080/1028415X.2017.1312841, 10.1080/1028415x.2017.1312841] Papadaki A, 2016, J NUTR EDUC BEHAV, V48, P706, DOI 10.1016/j.jneb.2016.08.003 Papamiltiadous ES, 2016, BMC GASTROENTEROL, V16, DOI 10.1186/s12876-016-0426-3 Peeters R, 2023, MED CARE RES REV, V80, P266, DOI [10.1177/10775587221118156, 10.1111/eva.13711] Rao M, 2013, BMJ OPEN, V3, DOI 10.1136/bmjopen-2013-004277 Scannell N, 2020, INT J ENV RES PUB HE, V17, DOI 10.3390/ijerph17249321 Sofi F, 2014, PUBLIC HEALTH NUTR, V17, P2769, DOI 10.1017/S1368980013003169 Vaismoradi M, 2013, NURS HEALTH SCI, V15, P398, DOI 10.1111/nhs.12048 Vincent-Baudry S, 2005, AM J CLIN NUTR, V82, P964, DOI 10.1093/ajcn/82.5.964 WILLETT WC, 1995, AM J CLIN NUTR, V61, p1402S, DOI 10.1093/ajcn/61.6.1402S Yeh MC, 2008, HEALTH PROMOT INT, V23, P42, DOI 10.1093/heapro/dam044 Zazpe I, 2008, J AM DIET ASSOC, V108, P1134, DOI 10.1016/j.jada.2008.04.011 NR 32 TC 10 Z9 11 U1 0 U2 6 PU WILEY PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0952-3871 EI 1365-277X J9 J HUM NUTR DIET JI J. Hum. Nutr. Diet. PD JUN PY 2023 VL 36 IS 3 BP 592 EP 602 DI 10.1111/jhn.13069 EA AUG 2022 PG 11 WC Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Nutrition & Dietetics GA G5NU7 UT WOS:000844419700001 PM 35962482 OA Green Submitted, hybrid DA 2026-02-02 ER PT J AU Mascaró, CM Bouzas, C Montemayor, S Casares, M Gómez, C Ugarriza, L Borràs, PA Martínez, JA Tur, JA AF Mascaro, Catalina M. Bouzas, Cristina Montemayor, Sofia Casares, Miguel Gomez, Cristina Ugarriza, Lucia Borras, Pere-Antoni Martinez, J. Alfredo Tur, Josep A. TI Association between Stages of Hepatic Steatosis and Physical Activity Performance in Adults with Metabolic Syndrome: A Cross-Sectional Analysis in FLIPAN Study SO NUTRIENTS LA English DT Article DE physical activity; Mediterranean diet; Mediterranean lifestyle; non-alcoholic fatty liver disease; hepatic steatosis; fitness tests ID FATTY LIVER-DISEASE; LIFE-STYLE; ACTIVITY QUESTIONNAIRE; SOCIOECONOMIC-STATUS; EXERCISE; SLEEP; DIET; VALIDATION; ACTIGRAPHY; RISK AB Background: Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease. The best treatment now is a healthy lifestyle with a Mediterranean diet and physical activity (PA). Objective: To assess the association between stages of hepatic steatosis and physical activity performance in adults with metabolic syndrome. Design: Cross-sectional study in 155 participants (40-60 years old) with MetS, a diagnosis of NAFLD by magnetic resonance imaging and BMI (body mass index) between 27 and 40 kg/m(2). Methods: Stages of hepatic steatosis were assessed and defined according to the percentage of intrahepatic fat contents: stage 0 <= 6.4% (control group); stage 1 = 6.4-17.4%; stage 2 >= 17.4%. Fitness was assessed through ALPHA-FIT test battery for adults, aerobic capacity by Chester-step test and PA by accelerometry and Minnesota questionnaire. Results: Participants without NAFLD reported more years of education and major socioeconomic status than participants with NAFLD. A higher percentage of people in the most advanced stage of NAFLD were no smokers and no alcohol consumers. They also had higher stages of steatosis, lower sitting handgrip, standing handgrip, Chester step test values, sleep efficiency, and energy expenditure, and higher intensity of light and moderate physical activity, and self-reported physical activity. Conclusions: NAFLD patients showed lower fitness status, aerobic capacity, sleep efficiency and energy expenditure than non-NAFLD participants. C1 [Mascaro, Catalina M.; Bouzas, Cristina; Montemayor, Sofia; Gomez, Cristina; Ugarriza, Lucia; Tur, Josep A.] Univ Balearic Isl IUNICS, Res Grp Community Nutr & Oxidat Stress, Palma De Mallorca 07122, Spain. [Mascaro, Catalina M.; Bouzas, Cristina; Montemayor, Sofia; Gomez, Cristina; Ugarriza, Lucia; Tur, Josep A.] Hlth Inst Balearic Isl IDISBA, Palma De Mallorca 07120, Spain. [Bouzas, Cristina; Tur, Josep A.] Inst Salud Carlos III ISCIII, CIBEROBN Physiopathol Obes & Nutr CB12 03 30038, Madrid 28029, Spain. [Casares, Miguel] Red Asistencial Juaneda, Radiodiag Serv, Palma De Mallorca 07011, Spain. [Gomez, Cristina] Univ Hosp Son Espases, Clin Anal Serv, Palma De Mallorca 07120, Spain. [Ugarriza, Lucia] Camp Redo Primary Hlth Care Ctr, Palma De Mallorca 07010, Spain. [Borras, Pere-Antoni] Univ Balearic Isl, Dept Pedag & Specif Didact, Area Phys Educ & Sports, Palma De Mallorca 07122, Spain. [Martinez, J. Alfredo] CEI UAM CSIC, Cardiomet Precis Nutr Program, IMDEA Food, Madrid 28049, Spain. [Martinez, J. Alfredo] Univ Navarra, Dept Nutr Food Sci & Physiol, Pamplona 31008, Spain. C3 CIBER - Centro de Investigacion Biomedica en Red; CIBEROBN; Hospital Universitari Son Espases; Universitat de les Illes Balears; Consejo Superior de Investigaciones Cientificas (CSIC); IMDEA Food Institute; University of Navarra RP Tur, JA (通讯作者)，Univ Balearic Isl IUNICS, Res Grp Community Nutr & Oxidat Stress, Palma De Mallorca 07122, Spain.; Tur, JA (通讯作者)，Hlth Inst Balearic Isl IDISBA, Palma De Mallorca 07120, Spain.; Tur, JA (通讯作者)，Inst Salud Carlos III ISCIII, CIBEROBN Physiopathol Obes & Nutr CB12 03 30038, Madrid 28029, Spain. EM c.mascaro@uib.es; cristina.bouzas@uib.es; sofiamf16@gmail.com; casaresmiguel@gmail.com; cristina.gomez@ssib.es; luciaugarriza@gmail.com; pa-borras@uib.es; jalfredo.martinez@imdea.org; pep.tur@uib.es RI ; Tur, Josep/AAE-5748-2020; Bouzas, Cristina/AAE-2069-2019; BORRAS, PERE A/H-2403-2013; Martínez, J./K-8709-2014 OI GOMEZ COBO, CRISTINA/0000-0002-9776-4730; Tur, Josep/0000-0002-6940-0761; BORRAS, PERE A/0000-0001-6793-7592; FU Fundacio La Marato TV3 (Spain) [201630.10]; Instituto de Salud Carlos III through the CIBEROBN [CB12/03/30038]; Proyecto Intramural CIBER [OBN18PI03]; European Regional Development Fund; IDISBA Grants; Spanish Ministry of Education FX Fundacio La Marato TV3 (Spain) project ref. 201630.10. Instituto de Salud Carlos III through the CIBEROBN CB12/03/30038, and Proyecto Intramural CIBER OBN18PI03, which are co-funded by the European Regional Development Fund. Other funding received: IDISBA Grants (FOLIUM, PRIMUS, SYNERGIA, and LIBERI). Catalina M. Mascaro received an FPU PhD Grant from the Spanish Ministry of Education. 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Mediterranean diet; platelet activity; liver fibrosis; cardiovascular risk; thromboxane; Pro-C3 ID METABOLIC SYNDROME; OXIDATIVE STRESS; ADHERENCE; FIBROSIS; THROMBOXANE-A2; CONSUMPTION; PREVALENCE; MECHANISMS; MANAGEMENT; SEVERITY AB The Mediterranean diet (Med-Diet) is considered the most effective dietary patterns to obtain weight loss in NAFLD patients. Previous evidence suggested that Med-Diet adherence could reduce cardiovascular risk and have a beneficial effect on NAFLD severity. Aim of the study was to investigate the relationship between Med-Diet adherence, platelet activation (PA), and liver collagen deposition. The study was performed in 655 consecutive NAFLD outpatients from the PLINIO study, a prospective observational cohort study aimed to identify non-conventional predictors of liver fibrosis progression in NAFLD. PA was measured by the serum thromboxane B-2 (TxB(2)), and liver collagen deposition by N-terminal propeptide of type III collagen (Pro-C3). Adherence to the Med-diet was investigated by a short nine-item validated dietary questionnaire. Patients with high Med-Diet adherence were older and had less metabolic syndrome and lower serum triglycerides, GGT, TxB(2), and Pro-C3. At multivariate regression analyses, in the linear model, the Med-Diet score negatively correlated with both TxB(2) (Beta = -0.106; p = 0.009) and Pro-C3 (Beta = -0.121; p = 0.002) and in the logistic model high adherence inversely correlated with higher TxB(2) tertiles (II tertile: OR = 0.576, p = 0.044; III tertile: OR = 0.556, p = 0.026) and Pro-C3 tertile (III tertile: OR = 0.488, p = 0.013). Low consumption of red meat inversely correlated with higher TxB(2) tertile (II tertile: OR = 0.448, p < 0.001, III tertile: OR = 0.567, p = 0.004). In conclusion, NAFLD patients with high adherence to the Med-Diet show lower PA and liver collagen deposition, suggesting a protective role of the Med-Diet against NAFLD progression and cardiovascular risk. In addition, the correlation between TxB(2) and Pro-C3 suggests a link between NAFLD severity and cardiovascular risk. C1 [Baratta, Francesco; Cammisotto, Vittoria; Coronati, Mattia; Nocella, Cristina; Pignatelli, Pasquale; Del Ben, Maria] Sapienza Univ Rome, Dept Clin Internal Anaesthesiol & Cardiovasc Sci, I-00161 Rome, Italy. [Tozzi, Giulia] IRCCS Bambino Gesu Childrens Hosp, Dept Pediat, Div Metab, I-00146 Rome, Italy. [Tozzi, Giulia] IRCCS Bambino Gesu Childrens Hosp, Dept Pediat, Res Unit Metab Biochem, I-00146 Rome, Italy. [Bartimoccia, Simona; Carnevale, Roberto] Sapienza Univ Rome, Dept Med Surg Sci & Biotechnol, I-04100 Latina, Italy. [Castellani, Valentina] Sapienza Univ Rome, Dept Gen Surg & Surg Special Paride Stefanini, I-00161 Rome, Italy. [D'Amico, Alessandra] Univ Rome Foro Italico, Dept Movement Human & Hlth Sci, I-00135 Rome, Italy. [Angelico, Francesco] Sapienza Univ Rome, Dept Publ Hlth & Infect Dis, I-00161 Rome, Italy. [Carnevale, Roberto; Pignatelli, Pasquale] Mediterranea Cardioctr, I-80122 Naples, Italy. C3 Sapienza University Rome; IRCCS Bambino Gesu; IRCCS Bambino Gesu; Sapienza University Rome; Sapienza University Rome; Foro Italico University of Rome; Sapienza University Rome RP Baratta, F (通讯作者)，Sapienza Univ Rome, Dept Clin Internal Anaesthesiol & Cardiovasc Sci, I-00161 Rome, Italy. EM francesco.baratta@uniroma1.it; vittoria.cammisotto@uniroma1.it; giulia.tozzi@opbg.net; mattia.coronati@gmail.com; simona.bartimoccia@uniroma1.it; valentina.castellani@uniroma1.it; cristina.nocella@uniroma1.it; a.damico@studenti.uniroma4.it; francesco.angelico@uniroma1.it; roberto.carnevale@uniroma1.it; pasquale.pignatelli@uniroma1.it; maria.delben@uniroma1.it RI Cammisotto, Vittoria/W-5910-2019; pignatelli, pasquale/K-2116-2016; D’Amico, Alessana/IUN-1943-2023; Nocella, Cristina/K-2175-2016; Bartimoccia, Simona/K-7873-2016; Angelico, Francesco/AAB-6585-2020; DEL BEN, MARIA/AAE-7603-2020; Carnevale, Roberto/JMC-1138-2023; Castellani, Valentina/ODJ-2295-2025; Tozzi, Giulia/K-8605-2018 OI Cammisotto, Vittoria/0000-0003-1966-5945; Baratta, Francesco/0000-0003-1708-272X; pignatelli, pasquale/0000-0002-2265-7455; D’Amico, Alessana/0000-0002-5571-4583; Bartimoccia, Simona/0000-0002-6266-3059; DEL BEN, MARIA/0000-0003-1199-8454; Carnevale, Roberto/0000-0002-6216-9595; Castellani, Valentina/0000-0001-6455-4828; Coronati, Mattia/0000-0003-0052-1378; FU Sapienza - University of Rome FX This research received no external funding, APC was founded by Sapienza - University of Rome. 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Maciejewska-Markiewicz, D Binkowski, J Palma, J Taryma-Lesniak, O Kozlowska-Petriczko, K Borowski, K Baskiewicz-Halasa, M Hawrylkowicz, V Zalecka, P Ufnal, M Strapagiel, D Jarczak, J Skonieczna-Zydecka, K Ryterska, K Machalinski, B Wojdacz, TK Stachowska, E AF Sokolowska, Katarzyna Ewa Maciejewska-Markiewicz, Dominika Binkowski, Jan Palma, Joanna Taryma-Lesniak, Olga Kozlowska-Petriczko, Katarzyna Borowski, Konrad Baskiewicz-Halasa, Magdalena Hawrylkowicz, Viktoria Zalecka, Patrycja Ufnal, Marcin Strapagiel, Dominik Jarczak, Justyna Skonieczna-Zydecka, Karolina Ryterska, Karina Machalinski, Boguslaw Wojdacz, Tomasz Kazimierz Stachowska, Ewa TI Identified in blood diet-related methylation changes stratify liver biopsies of NAFLD patients according to fibrosis grade SO CLINICAL EPIGENETICS LA English DT Article DE Nutrition; Non-alcoholic fatty liver disease; Liver; Fibre; DNA methylation; Epigenetics; Acetylation; Mediterranean diet ID NONALCOHOLIC FATTY LIVER; DNA METHYLATION; GENE-EXPRESSION; DISEASE; ACETYLATION; ASSOCIATION; PREVALENCE AB Background High caloric diet and lack of physical activity are considered main causes of NAFLD, and a change in the diet is still the only effective treatment of this disease. However, molecular mechanism of the effectiveness of diet change in treatment of NAFLD is poorly understood. We aimed to assess the involvement of epigenetic mechanisms of gene expression regulation in treatment of NAFLD. Eighteen participants with medium- to high-grade steatosis were recruited and trained to follow the Mediterranean diet modified to include fibre supplements. At three timepoints (baseline, after 30 and 60 days), we evaluated adherence to the diet and measured a number of physiological parameters such as anthropometry, blood and stool biochemistry, liver steatosis and stiffness. We also collected whole blood samples for genome-wide methylation profiling and histone acetylation assessment. Results The diet change resulted in a decrease in liver steatosis along with statistically significant, but a minor change in BMI and weight of our study participants. The epigenetic profiling of blood cells identified significant genome-wide changes of methylation and acetylation with the former not involving regions directly regulating gene expression. Most importantly, we were able to show that identified blood methylation changes occur also in liver cells of NAFLD patients and the machine learning-based classifier that we build on those methylation changes was able to predict the stage of liver fibrosis with ROC AUC = 0.9834. Conclusion Methylomes of blood cells from NAFLD patients display a number of changes that are most likely a consequence of unhealthy diet, and the diet change appears to reverse those epigenetic changes. Moreover, the methylation status at CpG sites undergoing diet-related methylation change in blood cells stratifies liver biopsies from NAFLD patients according to fibrosis grade. C1 [Sokolowska, Katarzyna Ewa; Binkowski, Jan; Taryma-Lesniak, Olga; Borowski, Konrad; Wojdacz, Tomasz Kazimierz] Pomeranian Med Univ, Independent Clin Epignt Lab, Unii Lubelskiej 1, PL-71252 Szczecin, Poland. [Maciejewska-Markiewicz, Dominika; Hawrylkowicz, Viktoria; Zalecka, Patrycja; Ryterska, Karina; Stachowska, Ewa] Pomeranian Med Univ, Dept Human Nutr & Metabol, PL-71460 Szczecin, Poland. [Palma, Joanna; Skonieczna-Zydecka, Karolina] Pomeranian Med Univ, Dept Biochem Sci, PL-71460 Szczecin, Poland. [Kozlowska-Petriczko, Katarzyna] Pomeranian Med Univ, Translat Med Grp, PL-70204 Szczecin, Poland. [Kozlowska-Petriczko, Katarzyna] SPWSZ Hosp, Dept Gastroenterol & Internal Med, PL-71455 Szczecin, Poland. [Baskiewicz-Halasa, Magdalena; Machalinski, Boguslaw] Pomeranian Med Univ, Dept Gen Pathol, PL-70111 Szczecin, Poland. [Ufnal, Marcin] Med Univ Warsaw, Lab Ctr Preclin Res, Dept Expt Physiol & Pathophysiol, PL-02097 Warsaw, Poland. [Strapagiel, Dominik; Jarczak, Justyna] Univ Lodz, Fac Biol & Environm Protect, Dept Mol Biophys, Biobank Lab, PL-90237 Lodz, Poland. [Jarczak, Justyna] Polish Acad Sci, Nencki Inst Expt Biol, Lab Mol Basis Behav, Warsaw, Poland. C3 Pomeranian Medical University; Pomeranian Medical University; Pomeranian Medical University; Pomeranian Medical University; Pomeranian Medical University; Medical University of Warsaw; University of Lodz; Polish Academy of Sciences; Nencki Institute of Experimental Biology of the Polish Academy of Sciences RP Wojdacz, TK (通讯作者)，Pomeranian Med Univ, Independent Clin Epignt Lab, Unii Lubelskiej 1, PL-71252 Szczecin, Poland.; Stachowska, E (通讯作者)，Pomeranian Med Univ, Dept Human Nutr & Metabol, PL-71460 Szczecin, Poland. EM tomasz.wojdacz@pum.edu.pl; ewa.stachowska@pum.edu.pl RI ; Strapagiel, Dominik/IAN-9602-2023; Skonieczna-Żydecka, Karolina/K-7252-2014; Kozlowska-Petriczko, Katarzyna/AFS-8413-2022; Palma, Joanna/AAE-7293-2020; stachowska, Ewa/G-9521-2017; Maciejewska, Dominika/AAJ-7454-2020; Baśkiewicz-Hałasa, Magdalena/L-6646-2014; Ryterska, Karina/U-9950-2018; Taryma-Lesniak, Olga/LVQ-9132-2024 OI Sokolowska, Katarzyna Ewa/0000-0002-9250-5799; Strapagiel, Dominik/0000-0001-9752-4270; Borowski, Konrad/0000-0002-7835-3960; Bińkowski, Jan/0000-0003-2374-2907; Jarczak, Justyna/0000-0002-4357-7681; Ufnal, Marcin/0000-0003-0088-8284; Kozlowska-Petriczko, Katarzyna/0000-0002-2429-4643; Hawryłkowicz, Viktoria/0000-0002-8975-8824; FU MSWiA [DIALOG 0102/2019]; Polish Returns grant programme from The Polish National Agency for Academic Exchange [PPN/PPO/2018/1/00088/U] FX This study was funded by MSWiA DIALOG 0102/2019 and the Polish Returns grant programme from The Polish National Agency for Academic Exchange, grant number: PPN/PPO/2018/1/00088/U. 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Epigenetics PD DEC PY 2022 VL 14 IS 1 AR 157 DI 10.1186/s13148-022-01377-6 PG 16 WC Oncology; Genetics & Heredity WE Science Citation Index Expanded (SCI-EXPANDED) SC Oncology; Genetics & Heredity GA 6O5DM UT WOS:000890261700001 PM 36447285 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Della Corte, C Mosca, A Vania, A Alterio, A Iasevoli, S Nobili, V AF Della Corte, Claudia Mosca, Antonella Vania, Andrea Alterio, Arianna Iasevoli, Salvatore Nobili, Valerio TI Good adherence to the Mediterranean diet reduces the risk for NASH and diabetes in pediatric patients with obesity: The results of an Italian Study SO NUTRITION LA English DT Article DE NAFLD; Mediterranean diet; KIDMED; Obesity; Children ID FATTY LIVER-DISEASE; C-REACTIVE PROTEIN; OLIVE OIL; SEVERITY; CONSUMPTION; FRUCTOSE; FIBROSIS; CHILDREN; HEALTH; INDEX AB Objective: In the last decade, it was demonstrated that the Mediterranean diet (MD) represents an ideal diet for all age groups and has an important role in the prevention of metabolic and cardiovascular diseases, as well as nonalcoholic fatty liver disease (NAFLD). The aim of the present study was to analyze the association between adherence to the MD and NAFLD, with laboratory and histologic evaluation, in a group of children and adolescents with obesity. Methods: We enrolled 243 patients with obesity referred to our department from March 2014 to November 2015. In all patients, we performed abdominal ultrasound and laboratory assays. In selected cases (100 patients) liver biopsy was performed. Level of adherence to the MD was evaluated by a clinical questionnaire, the Mediterranean Diet Quality Index for children and adolescents (KIDMED). Results: The prevalence of low KIDMED score was significantly higher in patients with nonalcoholic steatohepatitis compared with other groups; poor adherence to the MD correlated with liver damage, the NAFLD activity score >5, and grade 2 fibrosis. 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Marques, Emily Agudelo, Juliana Liu, Chang Goedken, Michael Slitt, Angela L. Seeram, Navindra P. Ma, Hang TI Hepatoprotective and anti-inflammatory effects of a standardized pomegranate (Punica granatum) fruit extract in high fat diet-induced obese C57BL/6 mice SO INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION LA English DT Article DE Pomegranate (Punica granatum); high-fat diet; hepatoprotection; non-alcoholic fatty liver disease (NAFLD); anti-neuroinflammation ID LIVER-DISEASE; ALZHEIMERS-DISEASE; MEDITERRANEAN DIET; OXIDATIVE STRESS; INFLAMMATION; JUICE AB Diets rich in fats are linked to elevated systemic inflammation, which augments the progression of inflammatory-related disorders including non-alcoholic fatty liver disease (NAFLD) and neurodegenerative diseases. A phenolic-enriched pomegranate fruit extract (PE) was investigated for its hepatoprotective and anti-inflammatory effects in male C57BL/6 mice fed either a high-fat diet or a standard rodent diet with or without 1% of PE for 12 weeks. Mouse livers and hippocampi were evaluated for the expression of genes associated with NAFLD and inflammation by multiplexed gene analysis. PE alleviated diet-induced fatty liver and suppressed hepatic lipid regulating genes including Cd36, Fas, Acot2 and Slc27a1. In addition, PE suppressed gene expression of pro-inflammatory cytokines including Il-1 alpha, Il-7, Il-11, Ifn alpha, Tnf alpha and Lepr in the hippocampi. Our findings support the protective effects of PE against high-fat diet-induced hepatic and neurological disease. C1 [Pfohl, Marisa; DaSilva, Nicholas A.; Marques, Emily; Agudelo, Juliana; Liu, Chang; Slitt, Angela L.; Seeram, Navindra P.; Ma, Hang] Univ Rhode Isl, Coll Pharm, Dept Biomed & Pharmaceut Sci, Greenhouse Rd, Kingston, RI 02881 USA. [DaSilva, Nicholas A.; Slitt, Angela L.; Seeram, Navindra P.; Ma, Hang] Univ Rhode Isl, George & Anne Ryan Inst Neurosci, Kingston, RI 02881 USA. [Goedken, Michael] Rutgers State Univ, Rutgers Translat Sci, Piscataway, NJ USA. C3 University of Rhode Island; University of Rhode Island; Rutgers University System; Rutgers University New Brunswick RP Slitt, AL; Seeram, NP; Ma, H (通讯作者)，Univ Rhode Isl, Coll Pharm, Dept Biomed & Pharmaceut Sci, Greenhouse Rd, Kingston, RI 02881 USA. EM aslitt@uri.edu; nseeram@uri.edu; hang_ma@uri.edu RI Ma, Hang/AGQ-9726-2022; Seeram, Navindra/Q-6051-2017; Marques, Emily/CAJ-3224-2022; Liu, Chang/J-6985-2019 OI Pfohl, Marisa/0000-0002-4544-6626; DaSilva, Nicholas/0000-0003-1925-0790; Marques, Emily/0000-0001-6819-8154; Liu, Chang/0000-0002-1397-0124; Goedken, Michael Jacob/0009-0005-8842-8371 FU University of Rhode Island Council; National Institute of General Medical Sciences [P20GM103430] Funding Source: NIH RePORTER FX University of Rhode Island Council for Research GrantThis study was financially supported by a grant from the University of Rhode Island Council for Research Grant. 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PD MAY 19 PY 2021 VL 72 IS 4 BP 499 EP 510 DI 10.1080/09637486.2020.1849041 EA NOV 2020 PG 12 WC Food Science & Technology; Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Food Science & Technology; Nutrition & Dietetics GA SB4IT UT WOS:000590110400001 PM 33203257 OA Green Submitted DA 2026-02-02 ER PT J AU Meneghel, P Pinto, E Russo, FP AF Meneghel, Paola Pinto, Elisa Russo, Francesco Paolo TI Physiopathology of nonalcoholic fatty liver disease: from diet to nutrigenomics SO CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE LA English DT Review DE de-novo lipogenesis; Mediterranean diet; microbiota; NAFLD; saturated fatty acids AB Purpose of review Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease worldwide and is strongly associated with metabolic disorders, such as obesity, type 2 diabetes mellitus, and metabolic syndrome, to the extent that a new definition of metabolic associated fatty liver disease has been proposed. Recent findings Insulin resistance, worsened by a high-fat and high-carbohydrate diet, is the key to the physiopathology of hepatic steatosis. This is driven by several mechanisms that are mostly activated at a genetic level, such as de-novo lipogenesis and triglyceride synthesis. Therefore, many diet regimens have been studied, although significant controversies remain regarding their metabolic effects and long-term sustainability. Summary In this review, we summarized the role and effects of the main macronutrients on the development of NAFLD and discussed the molecular mechanisms involved. We also discussed the importance of genetic polymorphisms, epigenetic alterations, and dysbiosis to determine if lifestyle modification and a specific dietary regimen could be an essential part of NAFLD treatment. C1 [Meneghel, Paola; Pinto, Elisa; Russo, Francesco Paolo] Univ Hosp Padua, Dept Surg Oncol & Gastroenterol, I-35128 Padua, Italy. C3 University of Padua; Azienda Ospedaliera - Universita di Padova RP Russo, FP (通讯作者)，Univ Hosp Padua, Dept Surg Oncol & Gastroenterol, I-35128 Padua, Italy. EM francescopaolo.russo@unipd.it RI ; RUSSO, FRANCESCO PAOLO/ABN-5412-2022 OI Pinto, Elisa/0000-0002-5658-942X; RUSSO, FRANCESCO PAOLO/0000-0003-4127-8941 CR Abenavoli L, 2017, NUTRIENTS, V9, DOI 10.3390/nu9080870 Albillos A, 2020, J HEPATOL, V72, P558, DOI 10.1016/j.jhep.2019.10.003 Andres-Hernando A, 2020, CELL METAB, V32, P117, DOI 10.1016/j.cmet.2020.05.012 Angelini G, 2021, GUT, V70, P1098, DOI 10.1136/gutjnl-2020-322073 Anstee QM, 2022, JHEP REP, V4, DOI 10.1016/j.jhepr.2021.100411 Beam A, 2021, NUTRIENTS, V13, DOI 10.3390/nu13082795 Bordoni L, 2021, ANTIOXIDANTS-BASEL, V10, DOI 10.3390/antiox10070994 Cohen CC, 2021, J CLIN INVEST, V131, DOI 10.1172/JCI150996 Dallio M, 2021, NUTRIENTS, V13, DOI 10.3390/nu13051679 de Groot P, 2020, GUT, V69, P502, DOI 10.1136/gutjnl-2019-318320 Díaz LA, 2022, LANCET GASTROENTEROL, V7, P552, DOI 10.1016/S2468-1253(22)00008-5 DiStefano JK, 2020, CELL MOL LIFE SCI, V77, P2079, DOI 10.1007/s00018-019-03390-0 Eslam M, 2020, J HEPATOL, V73, P202, DOI 10.1016/j.jhep.2020.03.039 Gabbia D, 2021, FRONT NUTR, V8, DOI 10.3389/fnut.2021.715183 Gadaleta RM, 2020, EBIOMEDICINE, V54, DOI 10.1016/j.ebiom.2020.102719 Hashem A, 2021, SEMIN LIVER DIS, V41, P435, DOI 10.1055/s-0041-1731704 He KY, 2020, BRIT J NUTR, V124, P1, DOI 10.1017/S0007114520000914 Hydes TJ, 2020, CLIN MOL HEPATOL, V26, P383, DOI 10.3350/cmh.2020.0067 Jensen T, 2018, J HEPATOL, V68, P1063, DOI 10.1016/j.jhep.2018.01.019 Satu KJ, 2022, BMC NUTR, V8, DOI 10.1186/s40795-022-00524-9 Kanwal F, 2021, METABOLISM, V122, DOI 10.1016/j.metabol.2021.154822 Lombardi R, 2020, INT J MOL SCI, V21, DOI 10.3390/ijms21228761 Lottenberg AM, 2012, J NUTR BIOCHEM, V23, P1027, DOI 10.1016/j.jnutbio.2012.03.004 Marchesini G., 2016, J HEPATOL, V64, p1388 1402 Marchesini G., 2021, EAT WEIGHT DISORD-ST, V27, P1603 Meir AY, 2021, GUT, V70, P2085, DOI 10.1136/gutjnl-2020-323106 Nagashimada M, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22158008 Paik JM, 2022, HEPATOL COMMUN, V6, P90, DOI 10.1002/hep4.1707 Pugliese N, 2022, EUR J CLIN INVEST, V52, DOI 10.1111/eci.13659 Rom O, 2020, SCI TRANSL MED, V12, DOI 10.1126/scitranslmed.aaz2841 Scott SA, 2020, P NATL ACAD SCI USA, V117, P19376, DOI 10.1073/pnas.2000047117 Singh RP, 2020, FRONT CELL INFECT MI, V10, DOI 10.3389/fcimb.2020.00376 Softic S, 2020, CRIT REV CL LAB SCI, V57, P308, DOI 10.1080/10408363.2019.1711360 Spinler Jennifer K, 2020, ExRNA, V2, DOI [10.1186/s41544-020-00053-2, 10.1186/s41544-020-00053-2] Tryndyak VP, 2022, EPIGENETICS-US, V17, P1462, DOI 10.1080/15592294.2022.2043590 Van Name MA, 2020, J NUTR, V150, P2314, DOI 10.1093/jn/nxaa183 Lujan PV, 2021, NUTRIENTS, V13, DOI 10.3390/nu13051442 Yang XY, 2020, INT J BIOL SCI, V16, P2357, DOI 10.7150/ijbs.46405 Yang YB, 2021, GUT, V70, P1495, DOI 10.1136/gutjnl-2020-320777 Yki-Järvinen H, 2021, NAT REV GASTRO HEPAT, V18, P770, DOI 10.1038/s41575-021-00472-y Zhao S, 2020, NATURE, V579, P586, DOI 10.1038/s41586-020-2101-7 NR 41 TC 7 Z9 9 U1 0 U2 13 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 1363-1950 EI 1473-6519 J9 CURR OPIN CLIN NUTR JI Curr. Opin. Clin. Nutr. Metab. Care PD SEP PY 2022 VL 25 IS 5 BP 329 EP 333 DI 10.1097/MCO.0000000000000859 PG 5 WC Endocrinology & Metabolism; Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Endocrinology & Metabolism; Nutrition & Dietetics GA 3M2QX UT WOS:000835304800011 PM 35920204 OA Green Submitted, hybrid DA 2026-02-02 ER PT J AU Shim, P Choi, D Park, Y AF Shim, Poyoung Choi, Dongho Park, Yongsoon TI Association of Blood Fatty Acid Composition and Dietary Pattern with the Risk of Non-Alcoholic Fatty Liver Disease in Patients Who Underwent Cholecystectomy SO ANNALS OF NUTRITION AND METABOLISM LA English DT Article DE Dietary pattern; n-3 polyunsaturated fatty acid; Non-alcoholic fatty liver disease; Patient with cholecystectomy ID HEPATIC STEATOSIS; MEDITERRANEAN DIET; CONSUMPTION; POPULATION; NAFLD; RATS; EPIDEMIOLOGY; CHOLESTEROL; SEVERITY; ADULTS AB Background/aims: The relationship between diet and non-alcoholic fatty liver disease (NAFLD) in patients with gallstone disease and in those who have a high risk for NAFLD has not been investigated. This study was conducted to investigate the association between the risk of NAFLD and dietary pattern in patients who underwent cholecystectomy. Additionally, we assessed the association between erythrocyte fatty acid composition, a marker for diet, and the risk of NAFLD. Methods: Patients (n = 139) underwent liver ultrasonography to determine the presence of NAFLD before laparoscopic cholecystectomy, reported dietary intake using food frequency questionnaire, and were assessed for blood fatty acid composition. Results: Fifty-eight patients were diagnosed with NAFLD. The risk of NAFLD was negatively associated with 2 dietary patterns: consuming whole grain and legumes and consuming fish, vegetables, and fruit. NAFLD was positively associated with the consumption of refined grain, meat, processed meat, and fried foods. Additionally, the risk of NAFLD was positively associated with erythrocyte levels of 16:0 and 18:2t, while it was negatively associated with 20:5n3, 22:5n3, and Omega-3 Index. Conclusion: The risk of NAFLD was negatively associated with a healthy dietary pattern of consuming whole grains, legumes, vegetables, fish, and fruit and with an erythrocyte level of n-3 polyunsaturated fatty acids rich in fish. (C) 2017 S. Karger AG, Basel. C1 [Shim, Poyoung; Park, Yongsoon] Hanyang Univ, Coll Med, Dept Food & Nutr, Seoul, South Korea. [Choi, Dongho] Hanyang Univ, Coll Med, Dept Surg, Seoul, South Korea. C3 Hanyang University; Hanyang University RP Park, Y (通讯作者)，Hanyang Univ, Dept Food & Nutr, Wangsimni Ro 222, Seoul 04763, South Korea. EM yongsoon@hanyang.ac.kr RI Park, Yongsoon/E-6968-2017 OI Park, Yongsoon/0000-0001-5110-5716; Choi, Dongho/0000-0002-1255-1964 FU Korean Research Foundation grant - Korean government [2015R1D1A1A09060823] FX The authors have no conflicts of interest to disclose. This study was supported by a Korean Research Foundation grant funded by the Korean government (2015R1D1A1A09060823). 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Nutr. Metab. PY 2017 VL 70 IS 4 BP 303 EP 311 DI 10.1159/000475605 PG 9 WC Endocrinology & Metabolism; Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Endocrinology & Metabolism; Nutrition & Dietetics GA FA0AY UT WOS:000405094100006 PM 28595185 DA 2026-02-02 ER PT J AU Worm, N AF Worm, Nicolai TI Beyond Body Weight-Loss: Dietary Strategies Targeting Intrahepatic Fat in NAFLD SO NUTRIENTS LA English DT Review DE fatty liver; NAFLD; de novo lipogenesis; weight loss; nutritional therapy meal replacement; low-carbohydrate diet; Mediterranean diet ID DE-NOVO LIPOGENESIS; LOW-CALORIE DIET; LIVER-DISEASE; HEPATIC STEATOSIS; INSULIN-RESISTANCE; LOSS MAINTENANCE; PLANT PROTEIN; METAANALYSIS; ACIDS; CARBOHYDRATE AB Non-alcoholic fatty liver disease (NAFLD) has emerged as the most prevalent liver disease in industrialized countries. It is regarded as the hepatic manifestation of the metabolic syndrome (MetS) resulting from insulin resistance. Moreover, insulin resistance impairs glycogen synthesis, postprandially diverting a substantial amount of carbohydrates to the liver and storing them there as fat. NAFLD has far-reaching metabolic consequences involving glucose and lipoprotein metabolism disorders and risk of cardiovascular disease, the leading cause of death worldwide. No pharmaceutical options are currently approved for the treatment of NAFLD. Exercise training and dietary interventions remain the cornerstone of NAFLD treatment. Current international guidelines state that the primary goal of nutritional therapy is to reduce energy intake to achieve a 7%-10% reduction in body weight. Meal replacement therapy (formula diets) results in more pronounced weight loss compared to conventional calorie-restricted diets. However, studies have shown that body mass index (BMI) or weight reduction is not obligatory for decreasing hepatic fat content or to restore normal liver function. 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GASTROEN HEPAT, V30, P631, DOI [10.1097/meg.0000000000001075, 10.1097/MEG.0000000000001075] NR 85 TC 57 Z9 65 U1 1 U2 20 PU MDPI PI BASEL PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND EI 2072-6643 J9 NUTRIENTS JI Nutrients PD MAY PY 2020 VL 12 IS 5 AR 1316 DI 10.3390/nu12051316 PG 12 WC Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Nutrition & Dietetics GA MB0AV UT WOS:000542272700236 PM 32384593 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Jennison, E Byrne, CD AF Jennison, Erica Byrne, Christopher D. TI The role of the gut microbiome and diet in the pathogenesis of non-alcoholic fatty liver disease SO CLINICAL AND MOLECULAR HEPATOLOGY LA English DT Review DE Non-alcoholic fatty liver disease; Gastrointestinal microbiome; Dysbiosis; Diet ID GREEN TEA EXTRACT; INCREASED INTESTINAL PERMEABILITY; TOLL-LIKE RECEPTOR-4; HEPATIC STEATOSIS; INSULIN SENSITIVITY; COFFEE CONSUMPTION; DOUBLE-BLIND; RISK-FACTORS; SYNBIOTIC SUPPLEMENTATION; MEDITERRANEAN DIET AB Non-alcoholic fatty liver disease (NAFLD) is the leading cause of chronic liver disease, with a prevalence that is increasing in parallel with the global rise in obesity and type 2 diabetes mellitus. The pathogenesis of NAFLD is complex and multifactorial, involving environmental, genetic and metabolic factors. The role of the diet and the gut microbiome is gaining interest as a significant factor in NAFLD pathogenesis. Dietary factors induce alterations in the composition of the gut microbiome (dysbiosis), commonly reflected by a reduction of the beneficial species and an increase in pathogenic microbiota. Due to the close relationship between the gut and liver, altering the gut microbiome can affect liver functions; promoting hepatic steatosis and inflammation. This review summarises the current evidence supporting an association between NAFLD and the gut microbiome and dietary factors. The review also explores potential underlying mechanisms underpinning these associations and whether manipulation of the gut microbiome is a potential therapeutic strategy to prevent or treat NAFLD. C1 [Jennison, Erica] Univ Hosp Southampton, Southampton Gen Hosp, Dept Chem Pathol, Tremona Rd, Southampton SO16 6YD, Hants, England. [Byrne, Christopher D.] Univ Southampton, Fac Med, Dept Nutr & Metab, Southampton, Hants, England. [Byrne, Christopher D.] Univ Hosp Southampton, Southampton Gen Hosp, Res Biomed Res Ctr, Southampton Natl Inst Hlth, Southampton, Hants, England. C3 University of Southampton; University of Southampton; University of Southampton RP Jennison, E (通讯作者)，Univ Hosp Southampton, Southampton Gen Hosp, Dept Chem Pathol, Tremona Rd, Southampton SO16 6YD, Hants, England. EM erica.jennison@uhs.nhs.uk OI Byrne, Christopher D/0000-0001-6322-7753 FU Southampton National Institute for Health Research Biomedical Research Centre, UK FX CDB is Principal Investigator for the Investigation of synbiotic treatment in NAFLD (INSYTE) trial (www.clinicaltrials.gov registration number NCT01680640). CDB is supported in part by the Southampton National Institute for Health Research Biomedical Research Centre, UK. 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Mol. Hepatol. PD JAN PY 2021 VL 27 IS 1 BP 22 EP 43 DI 10.3350/cmh.2020.0129 PG 22 WC Gastroenterology & Hepatology WE Science Citation Index Expanded (SCI-EXPANDED) SC Gastroenterology & Hepatology GA PP1ZJ UT WOS:000605666500002 PM 33291863 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Zivkovic, AM German, JB Sanyal, AJ AF Zivkovic, Angela M. German, J. Bruce Sanyal, Arun J. TI Comparative review of diets for the metabolic syndrome: implications for nonalcoholic fatty liver disease SO AMERICAN JOURNAL OF CLINICAL NUTRITION LA English DT Review DE nonalcoholic fatty liver disease; NAFLD; non-alcoholic steatohepatitis; NASH; diet; weight loss ID DE-NOVO LIPOGENESIS; CORONARY-HEART-DISEASE; ENDOPLASMIC-RETICULUM STRESS; AMINO-ACID SUPPLEMENTATION; CONJUGATED LINOLEIC-ACID; MEDITERRANEAN-STYLE DIET; LOW-CARBOHYDRATE DIET; CARDIOVASCULAR-DISEASE; HEPATIC STEATOSIS; INSULIN-RESISTANCE AB Nonalcoholic fatty liver disease (NAFLD) is a significant health problem and affects 70 million adults in the United States (30% of the adult population), and an estimated 20% of these individuals have the most severe form of NAFLD-nonalcoholic steatohepatitis (NASH). The mechanisms underlying disease development and progression are awaiting clarification. Insulin resistance and obesity-related inflammation, among other possible genetic, dietary, and lifestyle factors, are thought to play a key role. A program targeting gradual weight reduction and physical exercise continues to be the gold standard of treatment for all forms of NAFLD. Even though weight loss and dietary and lifestyle changes are recommended as primary treatment for fatty liver, little to no scientific evidence is available on diet and NAFLD. This article reviews the implications of current dietary approaches, including national guidelines and popular weight-loss diets, with a focus on determining the optimal diet to prescribe for NAFLD and NASH patients. The effects of macronutrient content (carbohydrate, fat, and protein ratios) and specific food components, such as soluble fiber, n- 3 fatty acids, and fructose, are discussed. The premises, effects, barriers, and issues related to current dietary guidelines and specific diets are discussed, and the question, "Will it work for the pathogenesis of NAFLD and NASH? ", is addressed. C1 Virginia Commonwealth Univ, Dept Internal Med, Div Gastroenterol Hepatol & Nutr, Richmond, VA 23298 USA. Univ Calif Davis, Dept Food Sci & Technol, Davis, CA 95616 USA. Nestle Res Ctr, CH-1000 Lausanne, Switzerland. C3 Virginia Commonwealth University; University of California System; University of California Davis; Nestle SA; Nestle Research Center RP Sanyal, AJ (通讯作者)，Virginia Commonwealth Univ, Dept Internal Med, Div Gastroenterol Hepatol & Nutr, PO Box 980341, Richmond, VA 23298 USA. 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J. Clin. Nutr. PD AUG PY 2007 VL 86 IS 2 BP 285 EP 300 DI 10.1093/ajcn/86.2.285 PG 16 WC Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Nutrition & Dietetics GA 198LN UT WOS:000248629700004 PM 17684197 DA 2026-02-02 ER PT J AU Guillén, N Navarro, MA Arnal, C Noone, E Arbonés-Mainar, JM Acín, S Surra, JC Muniesa, P Roche, HM Osada, J AF Guillen, Natalia Navarro, Maria A. Arnal, Carmen Noone, Enda Arbones-Mainar, Jose M. Acin, Sergio Surra, Joaquin C. Muniesa, Pedro Roche, Helen M. Osada, Jesus TI Microarray analysis of hepatic gene expression identifies new genes involved in steatotic liver SO PHYSIOLOGICAL GENOMICS LA English DT Article DE conjugated linoleic acid; apolipoprotein e-deficient mice; olive oil; hepatic steatosis; DNA microarrays; Syt1 ID CONJUGATED LINOLEIC-ACID; E KNOCKOUT MICE; ATHEROSCLEROTIC LESION DEVELOPMENT; CYSTATHIONINE BETA-SYNTHASE; FATTY LIVER; METABOLIC SYNDROME; ADIPOSE-TISSUE; INSULIN-RESISTANCE; BODY-COMPOSITION; DEFICIENT MICE AB Guillen N, Navarro MA, Arnal C, Noone E, Arbones-Mainar JM, Acin S, Surra JC, Muniesa P, Roche HM, Osada J. Microarray analysis of hepatic gene expression identifies new genes involved in steatotic liver. Physiol Genomics 37: 187-198, 2009. First published March 3, 2009; doi:10.1152/physiolgenomics.90339.2008. Trans- 10, cis-12-conjugated linoleic acid (CLA)-enriched diets promote fatty liver in mice, while cis-9, trans-11-CLA ameliorates this effect, suggesting regulation of multiple genes. To test this hypothesis, apoE-deficient mice were fed a Western-type diet enriched with linoleic acid isomers, and their hepatic gene expression was analyzed with DNA microarrays. To provide an initial screening of candidate genes, only 12 with remarkably modified expression between both CLA isomers were considered and confirmed by quantitative RTPCR. Additionally mRNA expression of 15 genes involved in lipid metabolism was also studied. Ten genes (Fsp27, Aqp4, Cd36, Ly6d, Scd1, Hsd3b5, Syt1, Cyp7b1, and Tff3) showed significant associations among their expressions and the degree of hepatic steatosis. Their involvement was also analyzed in other models of steatosis. In hyperhomocysteinemic mice lacking Cbs gene, only Fsp27, Cd36, Scd1, Syt1, and Hsd3b5 hepatic expressions were associated with steatosis. In apoE-deficient mice consuming olive-enriched diet displaying reduction of the fatty liver, only Fsp27 and Syt1 expressions were found associated. Using this strategy, we have shown that expression of these genes is highly associated with hepatic steatosis in a genetic disease such as Cbs deficiency and in two common situations such as Western diets containing CLA isomers or a Mediterranean-type diet. Conclusion: The results highlight new processes involved in lipid handling in liver and will help to understand the complex human pathology providing new proteins and new strategies to cope with hepatic steatosis. C1 [Guillen, Natalia; Navarro, Maria A.; Arbones-Mainar, Jose M.; Acin, Sergio; Surra, Joaquin C.; Osada, Jesus] Univ Zaragoza Salud Gabierno Aragon, Dept Bioquim & Biol Mol & Celular, Fac Vet, Inst Aragones Ciencias Salud, Zaragoza, Spain. [Arnal, Carmen] Univ Zaragoza, Fac Vet, Dept Patol Anim, E-50013 Zaragoza, Spain. [Noone, Enda; Roche, Helen M.] Univ Coll Dublin, Nutrigen Res Grp, Conway Inst, Dublin 2, Ireland. [Muniesa, Pedro] Univ Zaragoza, Dept Anat & Embriol & Genet Anim, Fac Vet, E-50013 Zaragoza, Spain. [Guillen, Natalia; Arnal, Carmen; Surra, Joaquin C.; Muniesa, Pedro; Osada, Jesus] Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr, Madrid, Spain. C3 University of Zaragoza; University College Dublin; University of Zaragoza; Instituto de Salud Carlos III; CIBER - Centro de Investigacion Biomedica en Red; CIBEROBN RP Osada, J (通讯作者)，Univ Zaragoza, Dept Biochem & Mol Biol, Sch Vet, Miguel Servet 177, E-50013 Zaragoza, Spain. EM Josada@unizar.es RI ; Surra Muñoz, Joaquín Carlos/G-1128-2014; Arbones-Mainar, Jose M/OOL-3701-2025; Guillén, Natalia/LCX-4359-2024; Acin, Sergio/S-5185-2017; Navarro, Ángeles/AAG-6089-2019; González-Muniesa, Pedro/H-2158-2015 OI Guillén Monzón, Natalia/0000-0001-6627-298X; Surra Muñoz, Joaquín Carlos/0000-0002-5841-0462; Roche, Helen/0000-0002-0628-3318; Arbones-Mainar, Jose M/0000-0002-8982-3737; Acin, Sergio/0000-0001-7335-2865; FU CICYT-FEDER [SAF2007-60173]; Gobierno de Aragon [PI025/08]; Redes DGA [B-69]; Fundacion Cuenca Villoro, DGA; FEGA-FEOGA; Wellcome Trust FX This research was funded by grants CICYT-FEDER (SAF2007-60173), Gobierno de Aragon (PI025/08) and Redes DGA (B-69). N. Guillen, S. Acin, and M. A. Navarro were recipients of Fundacion Cuenca Villoro, DGA, and FEGA-FEOGA fellowships. H. M. Roche was a recipient of The Wellcome Trust New Blood Fellowship. 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Genomics PD MAY PY 2009 VL 37 IS 3 BP 187 EP 198 DI 10.1152/physiolgenomics.90339.2008 PG 12 WC Cell Biology; Genetics & Heredity; Physiology WE Science Citation Index Expanded (SCI-EXPANDED) SC Cell Biology; Genetics & Heredity; Physiology GA 445CN UT WOS:000266027400004 PM 19258494 OA Green Submitted DA 2026-02-02 ER PT J AU Cardoso, BR Tan, SY Daly, RM Dalla Via, J Georgousopoulou, EN George, ES AF Cardoso, Barbara R. Tan, Sze-Yen Daly, Robin M. Dalla Via, Jack Georgousopoulou, Ekavi N. George, Elena S. TI Intake of Nuts and Seeds Is Associated with a Lower Prevalence of Nonalcoholic Fatty Liver Disease in US Adults: Findings from 2005-2018 NHANES SO JOURNAL OF NUTRITION LA English DT Article DE nuts; seeds; nonalcoholic fatty liver disease; liver; nonalcoholic steatohepatitis; Mediterranean diet ID NUTRITION EXAMINATION SURVEY; NATIONAL-HEALTH; CARDIOVASCULAR-DISEASE; CONSUMPTION; PATHOGENESIS; INDEX; NAFLD; RISK; DIET; EPIDEMIOLOGY AB Background: Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease globally. Nuts and seeds, due to their unique nutrient composition, may provide health benefits for the prevention of NAFLD. To date, no research has investigated the association between nut and seed intake and NAFLD prevalence in a non-Mediterranean Western population. Objectives: This study aimed to explore the association between nut and seed intake with NAFLD and metabolic biomarkers in a US representative sample. Methods: This cross-sectional study used data from 25,360 adults involved in the 2005-2018 NHANES, including adults (aged >= 18 y) with negative serology for hepatitis B and C and nonexcessive alcohol consumption. NAFLD was assessed using the fatty liver index (FLI); metabolic biomarkers were also assessed; nut and seed intake was evaluated from two 24-h dietary recalls. ANOVA and Poisson regression were used to establish the relation between nut and seed intake categories and NAFLD prevalence. Results: Nut and seed consumption was associated with a reduced prevalence of NAFLD. In females, in the fully adjusted model, this was significant across all nut and seed consumption categories but was most prominent in the moderate consumption group (7%, 15%, and 14% risk reduction in low, moderate, and adequate consumption categories, respectively, compared with nonconsumers). In males, moderate intake of nuts and seeds demonstrated a significantly lower prevalence of NAFLD (9%) compared with nonconsumers. Conclusions: Daily consumption for nuts and seeds was associated with a lower prevalence of NAFLD in non-Mediterranean, US adults, although the benefits seem to be greater in females across all categories of nut and seed consumption groups compared with nonconsumers. Both males and females presented with lower prevalence of NAFLD with intakes of 15-30 g/d. C1 [Cardoso, Barbara R.; Tan, Sze-Yen; Daly, Robin M.; Dalla Via, Jack; George, Elena S.] Deakin Univ, Sch Exercise & Nutr Sci, Inst Phys Act & Nutr IPAN, Geelong, Vic, Australia. [Cardoso, Barbara R.] Monash Univ, Dept Nutr Dietet & Food, Notting Hill, Vic, Australia. [Dalla Via, Jack] Edith Cowan Univ, Sch Med & Hlth Sci, Inst Nutr Res, Perth, WA, Australia. [Georgousopoulou, Ekavi N.] Univ Notre Dame Australia, Sch Med Sydney, Sydney, NSW, Australia. C3 Deakin University; Monash University; Edith Cowan University; The University of Notre Dame Australia; University of Notre Dame Australia - Sydney RP George, ES (通讯作者)，Deakin Univ, Sch Exercise & Nutr Sci, Inst Phys Act & Nutr IPAN, Geelong, Vic, Australia. EM elena.george@deakin.edu.au RI Georgousopoulou, Ekavi/AAC-2563-2019; Tan, Sze-Yen/H-5796-2019; George, Elena/J-3357-2019; Daly, Robin/AAN-2353-2020; Rita Cardoso, Barbara/Q-8280-2016 OI Georgousopoulou, Ekavi/0000-0002-0592-3838; Tan, Sze-Yen/0000-0002-9607-202X; George, Elena/0000-0002-1385-2371; Rita Cardoso, Barbara/0000-0002-6393-1377 FU Alfred Deakin Postdoctoral Research Fellowship FX Supported by an Alfred Deakin Postdoctoral Research Fellowship (to BRC). 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PD NOV PY 2021 VL 151 IS 11 BP 3507 EP 3515 DI 10.1093/jn/nxab253 PG 9 WC Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Nutrition & Dietetics GA XQ9MA UT WOS:000731863600025 PM 34522969 OA Bronze DA 2026-02-02 ER PT J AU Metro, D Buda, M Manasseri, L Corallo, F Cardile, D Lo Buono, V Quartarone, A Bonanno, L AF Metro, Daniela Buda, Martina Manasseri, Luigi Corallo, Francesco Cardile, Davide Lo Buono, Viviana Quartarone, Angelo Bonanno, Lilla TI Role of Nutrition in the Etiopathogenesis and Prevention of Nonalcoholic Fatty Liver Disease (NAFLD) in a Group of Obese Adults SO MEDICINA-LITHUANIA LA English DT Article DE NAFLD; micronutrients; Mediterranean diet; transaminases; prevention; cognitive impairment; cognitive rehabilitation ID VITAMIN-E; INFLAMMATORY BIOMARKERS; INSULIN-RESISTANCE; GENE-EXPRESSION; CARBOHYDRATE; DIET; RECOMMENDATIONS; EPIDEMIOLOGY; PATHOGENESIS; FRUCTOSE AB Nonalcoholic fatty liver disease (NAFLD) is liver damage characterized by an accumulation of triglycerides in hepatocytes of >5% (due to an alteration of the balance of the lipid metabolism in favour of lipogenesis compared to lipolysis) that is not induced by the consumption of alcohol. The pathology includes simple steatosis and nonalcoholic steatohepatitis, or NASH (steatosis associated with microinflammatory activities), which can evolve in 15% of subjects with hepatic fibrosis to cirrhosis and the development of hepatocellular carcinoma. The aim of this study is to report the role of macro- and micronutrients in the pathogenesis and prevention of NAFLD in obese subjects. A total of 22 obese or overweight patients with hepatic steatosis were monitored periodically, evaluating their eating habits, fasting glycaemia, lipid picture, liver enzymes, anthropometric parameters, nutrition status, liver ultrasound, oxidative stress, and adherence to the Mediterranean diet. A statistical analysis shows a significant positive relationship between total cholesterol and the Mediterranean adequacy index (MAI) (r = -0.57; p = 0.005) and a significant negative relationship between ALT transaminases and the MAI (r = -0.56; p = 0.007). Nutrition and diet are important factors in the pathogenesis and prevention of NAFLD. The dietary model, based on the canons of the Mediterranean diet, prevents and reduces the accumulation of fat in hepatocytes. Therefore, in agreement with other studies in the literature, we can state that a dietary model characterized by foods rich in fibre, carotenoids, polyphenols, omega 3 fatty acids, folic acid, and numerous other molecules is inversely correlated with the serum levels of ALT transaminases, an enzyme whose level increases when the liver is damaged and before the most obvious symptoms of organ damage appear. C1 [Metro, Daniela; Manasseri, Luigi] Univ Messina, Dept Biomed & Dent Sci & Morphofunct Imaging, I-98122 Messina, Italy. [Buda, Martina] UOC Gen Surg Oncol, Dept Oncol DAI, I-98125 Messina, Italy. [Corallo, Francesco; Cardile, Davide; Lo Buono, Viviana; Quartarone, Angelo; Bonanno, Lilla] IRCCS Ctr Neurolesi Bonino Pulejo, SS 113 Via Palermo, I-98124 Messina, Italy. C3 University of Messina; IRCCS Bonino Pulejo RP Cardile, D (通讯作者)，IRCCS Ctr Neurolesi Bonino Pulejo, SS 113 Via Palermo, I-98124 Messina, Italy. EM davide.cardile@irccsme.it RI Buono, Vicente/I-8474-2012; Cardile, Davide/AHD-2392-2022; corallo, francesco/K-5932-2016; Bonanno, Lilla/K-3937-2016 OI Cardile, Davide/0000-0003-2052-0970; corallo, francesco/0000-0003-4862-3832; Bonanno, Lilla/0000-0002-0282-405X FU current research funds of 2022 of the Ministry of Health, Italy FX This study was supported by the current research funds of 2022 of the Ministry of Health, Italy. 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J. Diabetes PD JUN PY 2025 VL 49 IS 4 BP 222 EP 236 DI 10.1016/j.jcjd.2025.04.003 EA AUG 2025 PG 15 WC Endocrinology & Metabolism WE Science Citation Index Expanded (SCI-EXPANDED) SC Endocrinology & Metabolism GA 6AG4J UT WOS:001548561900002 PM 40783292 DA 2026-02-02 ER PT J AU Zadeh, SH Mansoori, A Hosseinzadeh, M AF Hassani Zadeh, Shirin Mansoori, Anahita Hosseinzadeh, Mahdieh TI Relationship between dietary patterns and non-alcoholic fatty liver disease: A systematic review and meta-analysis SO JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY LA English DT Review DE healthy diet; Mediterranean diet; Western diet; dietary pattern; meta‐ analysis; non‐ alcoholic fatty liver disease; systematic review ID MEDITERRANEAN DIET; CARDIOVASCULAR-DISEASE; DIABETES-MELLITUS; RISK; PREVALENCE; ADHERENCE; ASSOCIATION; CONSUMPTION; EPIDEMIOLOGY; HYPERTENSION AB Background and Aim: Non-alcoholic fatty liver disease (NAFLD) is one of the most common causes of chronic liver disease. Previous studies have investigated the association between dietary patterns and NAFLD, but their results are contradictory. Therefore, we carried out this meta-analysis to examine the association between dietary patterns and NAFLD. Methods: We searched PubMed, Web of Science, Scopus, and Google Scholar databases until November 14, 2019, to identify the observational studies on the association between dietary patterns and NAFLD. We selected three dietary patterns of Western, Prudent, and Mediterranean. A random-effect model was used to compute the summary risk estimates. Odds ratios (ORs) that were reported for fully adjusted models and their confidence intervals (CIs) were extracted for meta-analysis. Heterogeneity between studies was assessed using Cochran's Q- and I-2 tests. Eighteen articles (n = 24 867 participants) were entered our systematic review and meta-analysis. Results: We determined that Western dietary patterns (n = 8787 participants) containing high levels of processed food, red meat, high-fat dairy, and refined grains could significantly increase NAFLD (OR = 1.56, CI = 1.27 to 1.92; P <= 0.001). However, the Prudent (n = 13 023 participants) (OR = 0.78, CI = 0.71 to 0.85; P <= 0.001) and Mediterranean dietary patterns (n = 3057 participants) (OR = 0.77, CI = 0.60 to 0.98; P = 0.41), defined by high intake of fruits, vegetables, whole grains, fish, and olive oil decreased the risk of this disease. Conclusions: We found that Western dietary patterns increased the risk of NAFLD by 56%, although the Prudent and Mediterranean dietary patterns reduced the risk of this disease by 22% and 23%, respectively. C1 [Hassani Zadeh, Shirin; Hosseinzadeh, Mahdieh] Shahid Sadoughi Univ Med Sci, Nutr & Food Secur Res Ctr, Yazd, Iran. [Hassani Zadeh, Shirin; Hosseinzadeh, Mahdieh] Shahid Sadoughi Univ Med Sci, Sch Publ Hlth, Dept Nutr, Yazd, Iran. [Mansoori, Anahita] Ahvaz Jundishapur Univ Med Sci, Sch Paramed Sci, Nutr & Metab Dis Res Ctr, Ahvaz, Iran. C3 Shahid Sadoughi University of Medical Sciences; Shahid Sadoughi University of Medical Sciences; Ahvaz Jundishapur University of Medical Sciences (AJUMS) RP Hosseinzadeh, M (通讯作者)，Shahid Sadoughi Univ Med Sci, Nutr & Food Secur Res Ctr, Yazd, Iran.; Hosseinzadeh, M (通讯作者)，Shahid Sadoughi Univ Med Sci, Sch Publ Hlth, Dept Nutr, Yazd, Iran. EM hoseinzade.mahdie@gmail.com RI hosseinzadeh, mahdieh/R-3531-2019; zadeh, Shirin/AAA-5376-2020; Mansoori, Anahita/G-3737-2016 OI Mansoori, Anahita/0000-0003-2935-9589 FU Nutrition and Food Security Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran FX The study was funded by the Nutrition and Food Security Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. 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Gastroenterol. Hepatol. PD JUN PY 2021 VL 36 IS 6 BP 1470 EP 1478 DI 10.1111/jgh.15363 EA DEC 2020 PG 9 WC Gastroenterology & Hepatology WE Science Citation Index Expanded (SCI-EXPANDED) SC Gastroenterology & Hepatology GA SO7RM UT WOS:000598251600001 PM 33269500 DA 2026-02-02 ER PT J AU Giraldi, L Miele, L Aleksovska, K Manca, F Leoncini, E Biolato, M Arzani, D Pirro, MA Marrone, G Cefalo, C Racco, S Liguori, A Rapaccini, G Miggiano, GA Gasbarrini, A Boccia, S Grieco, A AF Giraldi, L. Miele, L. Aleksovska, K. Manca, F. Leoncini, E. Biolato, M. Arzani, D. Pirro, M. A. Marrone, G. Cefalo, C. Racco, S. Liguori, A. Rapaccini, G. Miggiano, G. A. Gasbarrini, A. Boccia, S. Grieco, A. TI Mediterranean diet and the prevention of non-alcoholic fatty liver disease: results from a case-control study SO EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES LA English DT Article DE Epidemiology; Case-control; Mediterranean diet ID METABOLIC SYNDROME; PHYSICAL-ACTIVITY; LIFE-STYLE; NAFLD; EPIDEMIOLOGY; ADHERENCE; FRUCTOSE AB OBJECTIVE: Few studies report that Mediterranean dietary (MD) pattern has a beneficial role in the progression of non-alcoholic fatty liver disease (NAFLD). Evidence on its potential effect on the onset of disease are, however, scanty. With our study, we evaluated whether MD affects the risk of NAFLD with a large case-control study performed in Italy. PATIENTS AND METHODS: Three hundred and seventy-one cases of NAFLD and 444 controls were questioned on the demographic data and their dietary habits before diagnosis. Additionally, information about lifestyles and other related diseases, such as hypertension and diabetes mellitus were collected. The MD adherence was assessed using a pre-defined Mediterranean Diet Score (MDS). Odds ratios (OR) and 95% confidence intervals (CI) were obtained using a multiple logistic regression model. RESULTS: A high adherence to the MD is significantly associated with decreased risk of NAFLD (OR: 0.83 95% CI: 0.71-0.98). When the different MD components were examined separately, higher legumes consumption (OR: 0.62 95% CI: 0.38-0.99) and high fish consumption (OR 0.38 95% CI: 0.17- 0.85) were reported to be protective against NAFLD. CONCLUSIONS: Our study shows that a high adherence to the MD decreases the risk of NAFLD. C1 [Giraldi, L.; Boccia, S.] Fdn Policlin Univ A Gemelli IRCCS, Publ Hlth Area, Dept Woman & Child Hlth & Publ Hlth, Rome, Italy. [Miele, L.; Manca, F.; Pirro, M. A.; Cefalo, C.; Liguori, A.; Rapaccini, G.; Miggiano, G. A.; Gasbarrini, A.; Grieco, A.] Univ Cattolica Sacro Cuore, Univ Dept Translat Med & Surg, Rome, Italy. [Miele, L.; Biolato, M.; Marrone, G.; Racco, S.; Rapaccini, G.; Miggiano, G. A.; Gasbarrini, A.; Grieco, A.] Fdn Policlin Univ A Gemelli IRCCS, Dept Med & Surg, Rome, Italy. [Aleksovska, K.; Leoncini, E.; Arzani, D.; Boccia, S.] Univ Cattolica Sacro Cuore, Univ Dept Hlth Sci & Publ Hlth, Rome, Italy. C3 Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli; Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli; Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli; Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli RP Miele, L (通讯作者)，Univ Cattolica Sacro Cuore, Univ Dept Translat Med & Surg, Rome, Italy.; Miele, L (通讯作者)，Fdn Policlin Univ A Gemelli IRCCS, Dept Med & Surg, Rome, Italy. EM luca.miele@policlinicogemelli.it RI Liguori, Antonio/HCI-6530-2022; Miele, Luca/C-2255-2015; Gasbarrini, Antonio/AAB-8487-2019; Gasbarrini, Antonio/AAB-8487-2019; BIOLATO, Marco/AAC-6691-2022 OI Liguori, Antonio/0000-0002-0801-7152; Miele, Luca/0000-0003-3464-0068; Gasbarrini, Antonio/0000-0002-6230-1779; Gasbarrini, Antonio/0000-0003-4863-6924; Aleksovska, Katina/0000-0002-2372-4453; BIOLATO, Marco/0000-0002-5172-8208 FU PRIN 2010-2011 [2010C4JJWB]; Erasmus-Mundus -Western Balkans (ERAWEB2) [2013-2548/001-001-EMA2]; Catholic University Linea D1; Catholic University Linea D3 FX This study was supported by PRIN 2010-2011 (Prot. No. 2010C4JJWB) (to A.Gr), Catholic University Linea D1 (to A. Gr.) and Linea D3 (to A. Ga. e A. Gr.). The work of KA was supported by Erasmus-Mundus -Western Balkans (ERAWEB2) Contract No. 2013-2548/001-001-EMA2. CR Abenavoli L, 2014, WORLD J GASTROENTERO, V20, P16831, DOI 10.3748/wjg.v20.i45.16831 Alberti KGMM, 2005, LANCET, V366, P1059, DOI 10.1016/S0140-6736(05)67402-8 Aller R, 2015, NUTR HOSP, V32, P2518 Asrih M, 2014, CLIN NUTR, V33, P186, DOI 10.1016/j.clnu.2013.11.003 Babio N, 2009, PUBLIC HEALTH NUTR, V12, P1607, DOI 10.1017/S1368980009990449 Bach-Faig A, 2011, PUBLIC HEALTH NUTR, V14, P2274, DOI 10.1017/S1368980011002515 Baratta F, 2017, AM J GASTROENTEROL, V112, P1832, DOI 10.1038/ajg.2017.371 Bellentani S, 2010, DIGEST DIS, V28, P155, DOI 10.1159/000282080 Chung M, 2014, AM J CLIN NUTR, V100, P833, DOI 10.3945/ajcn.114.086314 De Luis DA, 2018, EUR REV MED PHARMACO, V22, P3865, DOI 10.26355/eurrev_201806_15271 Fan JG, 2013, J GASTROEN HEPATOL, V28, P81, DOI 10.1111/jgh.12244 Federico A, 2016, EUR REV MED PHARMACO, V20, P4731 Gasbarrini G, 2005, Eur Rev Med Pharmacol Sci, V9, P253 Georgoulis M, 2015, J HUM NUTR DIET, V28, P409, DOI 10.1111/jhn.12323 Giraldi L, 2017, EUR J CANCER PREV, V26, P418, DOI [10.1097/CEJ.0000000000000277, 10.1097/cej.0000000000000277] Kastorini CM, 2011, J AM COLL CARDIOL, V57, P1299, DOI 10.1016/j.jacc.2010.09.073 Kontogianni MD, 2014, CLIN NUTR, V33, P678, DOI 10.1016/j.clnu.2013.08.014 Liese AD, 2015, J NUTR, V145, P393, DOI 10.3945/jn.114.205336 Lim JS, 2010, NAT REV GASTRO HEPAT, V7, P251, DOI 10.1038/nrgastro.2010.41 Merra G, 2017, EUR REV MED PHARMACO, V21, P329 Miele L, 2017, EUR REV MED PHARMACO, V21, P86 Mouzaki M, 2012, J CLIN GASTROENTEROL, V46, P457, DOI 10.1097/MCG.0b013e31824cf51e Nascimbeni F, 2013, J HEPATOL, V59, P859, DOI 10.1016/j.jhep.2013.05.044 Oddy WH, 2013, AM J GASTROENTEROL, V108, P778, DOI 10.1038/ajg.2013.95 Paredes AH, 2012, CLIN LIVER DIS, V16, P397, DOI 10.1016/j.cld.2012.03.005 Romero-Gómez M, 2017, J HEPATOL, V67, P829, DOI 10.1016/j.jhep.2017.05.016 Ryan MC, 2013, J HEPATOL, V59, P138, DOI 10.1016/j.jhep.2013.02.012 Salvini Simonetta, 1996, Journal of Food Composition and Analysis, V9, P57, DOI 10.1006/jfca.1996.0007 Shi L, 2012, BIOMED ENVIRON SCI, V25, P383, DOI 10.3967/0895-3988.2012.04.002 Sofi F, 2014, PUBLIC HEALTH NUTR, V17, P2769, DOI 10.1017/S1368980013003169 Sofi F, 2014, WORLD J GASTROENTERO, V20, P7339, DOI 10.3748/wjg.v20.i23.7339 Starley BQ, 2010, HEPATOLOGY, V51, P1820, DOI 10.1002/hep.23594 Thiébaut ACM, 2007, ANN INTERN MED, V146, P65, DOI 10.7326/0003-4819-146-1-200701020-00012 Trappoliere M, 2005, Eur Rev Med Pharmacol Sci, V9, P299 Trovato FM, 2016, WORLD J HEPATOL, V8, P1459, DOI 10.4254/wjh.v8.i33.1459 Trovato FM, 2015, CLIN NUTR, V34, P86, DOI 10.1016/j.clnu.2014.01.018 Utzschneider KM, 2006, J CLIN ENDOCR METAB, V91, P4753, DOI 10.1210/jc.2006-0587 Yasui K, 2011, CLIN GASTROENTEROL H, V9, P428, DOI 10.1016/j.cgh.2011.01.023 Zelber-Sagi S, 2017, LIVER INT, V37, P936, DOI 10.1111/liv.13435 Zelber-Sagi S, 2017, WORLD J GASTROENTERO, V23, P1881, DOI 10.3748/wjg.v23.i10.1881 Zelber-Sagi S, 2011, WORLD J GASTROENTERO, V17, P3377, DOI 10.3748/wjg.v17.i29.3377 NR 41 TC 21 Z9 22 U1 0 U2 6 PU VERDUCI PUBLISHER PI ROME PA VIA GREGORIO VII, ROME, 186-00165, ITALY SN 1128-3602 J9 EUR REV MED PHARMACO JI Eur. Rev. Med. Pharmacol. Sci. PY 2020 VL 24 IS 13 BP 7391 EP 7398 DI 10.26355/eurrev_202007_21907 PG 8 WC Pharmacology & Pharmacy WE Science Citation Index Expanded (SCI-EXPANDED) SC Pharmacology & Pharmacy GA MN9OX UT WOS:000551170100022 PM 32706078 DA 2026-02-02 ER PT J AU Tyrovolas, S Panagiotakos, DB Georgousopoulou, EN Chrysohoou, C Skoumas, J Pan, W Tousoulis, D Pitsavos, C AF Tyrovolas, Stefanos Panagiotakos, Demosthenes B. Georgousopoulou, Ekavi N. Chrysohoou, Christina Skoumas, John Pan, William Tousoulis, Dimitrios Pitsavos, Christos TI The anti-inflammatory potential of diet and nonalcoholic fatty liver disease: the ATTICA study SO THERAPEUTIC ADVANCES IN GASTROENTEROLOGY LA English DT Article DE anti-inflammatory diet; ATTICA study; Greece; hepatic health; liver; nonalcoholic fatty liver disease ID HEPATIC STEATOSIS; MEDITERRANEAN DIET; HEPATOCELLULAR-CARCINOMA; EPIDEMIOLOGY; INFLAMMATION; CONSUMPTION; MARKERS; RISK; TRIGLYCERIDES; PATHOGENESIS AB Background: Nonalcoholic fatty liver disease (NAFLD) is correlated with low-grade inflammation and dietary habits. Until today, there have been limited epidemiologic data assessing the role of diet's inflammatory potential on NAFLD. The aim was to evaluate the relationship between an anti-inflammatory diet, as reflected by the Dietary Anti-Inflammation Index (D-AII), and NAFLD among cardiovascular disease (CVD)-free adults. Methods: ATTICA is a prospective, population-based study that recruited 3042 adults without pre-existing CVD from the Greek population (Whites; age > 18 years; 1514 men and 1528 women). D-AII was calculated using a standard procedure. The baseline study captured various sociodemographic, lifestyle and clinical characteristics as well as hepatic markers. These were used to calculate four NAFLD assessment indices: triglyceride-glucose (TyG) index, fatty liver index (FLI), hepatic steatosis index (HSI), and NAFLD Fatty Liver Score (NAFLD-FLS). Specific cutoffs were applied to capture NAFLD. Results: D-AII showed a significant inverse association with NAFLD, applying the four indices with NAFLD cutoffs [odds ratio (OR) with 95% confidence interval (CI); TyG (0.95, 0.93-0.98); HSI (0.89, 0.86-0.92); FLI (0.88, 0.85-0.91); NAFLD-FLS (0.89, 0.86-0.92)], after adjusting for various confounders. Participants in the highest D-AII tertile had lower odds of having NAFLD, compared with those in the lowest D-AII tertile [(OR, 95% CI); TyG (0.33, 0.24-0.47); HSI (0.13, 0.08-0.23); FLI (0.05, 0.02-0.11); NAFLD-FLS (0.13, 0.07-0.23)]. Anti-inflammatory nutrition was related to lower odds of NAFLD among daily alcohol drinkers and individuals with metabolic syndrome. Conclusions: Anti-inflammatory diet is an important predictor of NAFLD among adults without pre-existing CVD. Adherence to a high anti-inflammatory diet seems to contribute to NAFLD prevention. C1 [Panagiotakos, Demosthenes B.] Harokopio Univ Athens, Sch Hlth Sci & Educ, Dept Sci Dietet & Nutr, El Venizelou 70, Athens 17671, Greece. [Panagiotakos, Demosthenes B.] Univ Canberra, Greece Fac Hlth, Canberra, ACT, Australia. [Tyrovolas, Stefanos] Univ Barcelona, Fdn St Joan de Deu, Parc Sanitari St Joan de Deu, Barcelona, Spain. [Tyrovolas, Stefanos] Inst Salud Carlos III, Ctr Invest Biomed Red Salud Mental, CIBERSAM, Madrid, Spain. [Tyrovolas, Stefanos; Georgousopoulou, Ekavi N.] Harokopio Univ, Sch Hlth Sci & Educ, Dept Sci Dietet & Nutr, Athens, Greece. [Georgousopoulou, Ekavi N.] Univ Canberra, Fac Hlth, Canberra, ACT, Australia. [Georgousopoulou, Ekavi N.] Australian Natl Univ, Med Sch, Canberra, ACT, Australia. [Pan, William] Duke Univ, Nicholas Sch Environm, Durham, NC 27708 USA. [Chrysohoou, Christina; Skoumas, John; Tousoulis, Dimitrios; Pitsavos, Christos] Univ Athens, Sch Med, Cardiol Clin 1, Athens, Greece. C3 Harokopio University Athens; University of Canberra; University of Barcelona; CIBER - Centro de Investigacion Biomedica en Red; CIBERSAM; Instituto de Salud Carlos III; Harokopio University Athens; University of Canberra; Australian National University; Duke University; National & Kapodistrian University of Athens RP Panagiotakos, DB (通讯作者)，Harokopio Univ Athens, Sch Hlth Sci & Educ, Dept Sci Dietet & Nutr, El Venizelou 70, Athens 17671, Greece.; Panagiotakos, DB (通讯作者)，Univ Canberra, Greece Fac Hlth, Canberra, ACT, Australia. EM dbpanag@hua.gr RI Panagiotakos, Demosthenes/K-8294-2019; Tyrovolas, Stefanos/M-2758-2014; Pan, William/HTR-1125-2023; Georgousopoulou, Ekavi/AAC-2563-2019 OI Chrysohoou, Christina/0000-0002-6340-3996; Pan, William/0000-0002-7407-7399; Georgousopoulou, Ekavi/0000-0002-0592-3838 FU European Union's Horizon 2020 research and innovation programme [635316]; Hellenic Cardiology Society (HCS2002); Hellenic Atherosclerosis Society (HAS2003); Foundation for Education and European Culture; Miguel Servet Programme [CP18/00006]; Fondos Europeos de Desarrollo Regional; H2020 Societal Challenges Programme [635316] Funding Source: H2020 Societal Challenges Programme FX This project has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement No. 635316. The ATTICA study is supported by research grants from the Hellenic Cardiology Society (HCS2002) and the Hellenic Atherosclerosis Society (HAS2003). Stefanos Tyrovolas was supported by the Foundation for Education and European Culture, the Miguel Servet Programme (reference CP18/00006), and the Fondos Europeos de Desarrollo Regional. 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Adv. Gastroenterol. PD JUN PY 2019 VL 12 AR 1756284819858039 DI 10.1177/1756284819858039 PG 11 WC Gastroenterology & Hepatology WE Science Citation Index Expanded (SCI-EXPANDED) SC Gastroenterology & Hepatology GA JZ3JU UT WOS:000504999000001 PM 31258620 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Katsagoni, CN Papatheodoridis, GV Ioannidou, P Deutsch, M Alexopoulou, A Papadopoulos, N Papageorgiou, MV Fragopoulou, E Kontogianni, MD AF Katsagoni, Christina N. Papatheodoridis, George V. Ioannidou, Panagiota Deutsch, Melanie Alexopoulou, Alexandra Papadopoulos, Nikolaos Papageorgiou, Maria-Vasiliki Fragopoulou, Elizabeth Kontogianni, Meropi D. TI Improvements in clinical characteristics of patients with non-alcoholic fatty liver disease, after an intervention based on the Mediterranean lifestyle: a randomised controlled clinical trial SO BRITISH JOURNAL OF NUTRITION LA English DT Article DE Non-alcoholic fatty liver disease; Mediterranean diet; Mediterranean lifestyle; Weight loss; Sleep; Intervention ID INSULIN-RESISTANCE; TRANSIENT ELASTOGRAPHY; HEPATIC STEATOSIS; FIBROSIS SCORE; DIET; NAFLD; PATTERN; PATHOGENESIS; ASSOCIATION; CHOLESTEROL AB Lifestyle interventions remain the cornerstone therapy for non-alcoholic fatty liver disease (NAFLD). This randomised controlled single-blind clinical trial investigated the effect of Mediterranean diet (MD) or Mediterranean lifestyle, along with weight loss, in NAFLD patients. In all, sixty-three overweight/obese patients (50 (SD 11) years, BMI = 31.8 (SD 4.5)kg/m(2), 68% men) with ultrasonography-proven NAFLD (and elevated alanine aminotransferase (ALT) and/or gamma-glutamyl transpeptidase (GGT) levels) were randomised to the following groups: (A) control group (CG), (B) Mediterranean diet group (MDG) or (C) Mediterranean lifestyle group (MLG). Participants of MDG and MLG attended seven 60-min group sessions for 6 months, aiming at weight loss and increasing adherence to MD. In the MLG, additional guidance for increasing physical activity and improving sleep habits were given. Patients in CG received only written information for a healthy lifestyle. At the end of 6 months, 88.8% of participants completed the study. On the basis of intention-to-treat analysis, both MDG and MLG showed greater weight reduction and higher adherence to MD compared with the CG (all P < 0.05) at the end of intervention. In addition, MLG increased vigorous exercise compared with the other two study groups (P < 0.001) and mid-day rest/naps compared with CG (P = 0.04). MLG showed significant improvements in ALT levels (i.e. ALT < 40 U/l (P = 0.03) and 50% reduction of ALT levels (P = 0.009)) and liver stiffness (P = 0.004) compared with CG after adjusting for % weight loss and baseline values. MDG improved only liver stiffness compared with CG (P < 0.001) after adjusting for the aforementioned variables. Small changes towards the Mediterranean lifestyle, along with weight loss, can be a treatment option for patients with NAFLD. C1 [Katsagoni, Christina N.; Fragopoulou, Elizabeth; Kontogianni, Meropi D.] Harokopio Univ, Sch Hlth Sci & Educ, Dept Nutr & Dietet, 70 El Venizelou Str, Athens 17671, Greece. [Papatheodoridis, George V.; Ioannidou, Panagiota; Papageorgiou, Maria-Vasiliki] Natl & Kapodistrian Univ Athens, Dept Gastroenterol, Sch Med, Laiko Gen Hosp Athens, 17 Agiou Thoma Str, Athens 11527, Greece. [Deutsch, Melanie; Alexopoulou, Alexandra; Papadopoulos, Nikolaos] Natl & Kapodistrian Univ Athens, Sch Med, Dept Internal Med 2, Hippokrat Gen Hosp Athens, 114 Vassilissis Sophias Ave, Athens 11527, Greece. C3 Harokopio University Athens; National & Kapodistrian University of Athens; Laiko General Hospital; National & Kapodistrian University of Athens RP Kontogianni, MD (通讯作者)，Harokopio Univ, Sch Hlth Sci & Educ, Dept Nutr & Dietet, 70 El Venizelou Str, Athens 17671, Greece. EM mkont@hua.gr RI Papatheodoridis, George/A-4603-2008; Kontogianni, Meropi/AAN-6530-2021; Maria Melanie, Deutsch/I-3279-2019; PAPADOPOULOS, NIKOLAOS/ABE-1774-2021; Papadopoulos, Nikolaos/ABE-1774-2021; ALEXOPOULOU, ALEXANA/AAB-7698-2021; Fragopoulou, Elizabeth/AAN-2050-2021 OI Papatheodoridis, George/0000-0002-3518-4060; Kontogianni, Meropi/0000-0003-3168-8867; Maria Melanie, Deutsch/0000-0002-3410-8226; PAPADOPOULOS, NIKOLAOS/0000-0002-8702-1685; Papadopoulos, Nikolaos/0000-0002-4448-3468; Katsagoni, Christina N/0000-0003-4474-328X; ALEXOPOULOU, ALEXANA/0000-0003-1991-7436; FU Fellowship of Excellence for Postgraduate Research in Greece-Siemens Program - State Scholarships Foundation (IKY) FX C. N. K. has received a Fellowship of Excellence for Postgraduate Research in Greece-Siemens Program, awarded by the State Scholarships Foundation (IKY). However, the State Scholarships Foundation had no role in the design, analysis or writing of this article. This research received no specific grant from any funding agency, commercial or not-for-profit sectors. 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J. Nutr. PD JUL 28 PY 2018 VL 120 IS 2 BP 164 EP 175 DI 10.1017/S000711451800137X PG 12 WC Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Nutrition & Dietetics GA GL4RE UT WOS:000437142500006 PM 29947322 OA Bronze DA 2026-02-02 ER PT J AU Montemayor, S Mascaró, CM Ugarriza, L Casares, M Llompart, I Abete, I Zulet, MA Martínez, JA Tur, JA Bouzas, C AF Montemayor, Sofia Mascaro, Catalina M. Ugarriza, Lucia Casares, Miguel Llompart, Isabel Abete, Itziar Angeles Zulet, Maria Alfredo Martinez, J. Tur, Josep A. Bouzas, Cristina TI Adherence to Mediterranean Diet and NAFLD in Patients with Metabolic Syndrome: The FLIPAN Study SO NUTRIENTS LA English DT Article DE Mediterranean diet; NAFLD; non-alcoholic fat liver disease; intrahepatic fat contents; metabolic syndrome ID FATTY LIVER-DISEASE; HEPATIC STEATOSIS; SEVERITY; STEATOHEPATITIS; ASSOCIATIONS; FIBROSIS AB Unhealthy diet is an important factor in the progression of non-alcoholic fatty liver disease (NAFLD). Previous studies showed the benefits of a Mediterranean diet (MedDiet) on Metabolic syndrome (MetS), type 2 diabetes mellitus (T2DM), and cardiovascular diseases, which usually have a pathophysiological relationship with NAFLD. To assess the effect of adherence to a MedDiet on NAFLD in MetS patients after lifestyle intervention, this multicentre (Mallorca and Navarra, Spain) prospective randomized trial, with personalized nutritional intervention based on a customized MedDiet, coupled with physical activity promotion was performed to prevent, and reverse NAFLD among patients with MetS. The current analysis included 138 patients aged 40 to 60 years old, Body Mass Index (BMI) 27-40 kg/m(2), diagnosed with NAFLD using MRI, and MetS according to the International Diabetes Federation (IDF). A validated food frequency questionnaire was used to assess dietary intake. Adherence to Mediterranean diet by means of a 17-item validated questionnaire, anthropometrics, physical activity, blood pressure, blood biochemical parameters, and intrahepatic fat contents (IFC) were measured. The independent variable used was changes in MedDiet adherence, categorized in tertiles after 6 months follow-up. Subjects with high adherence to the MedDiet showed higher decreases in BMI, body weight, WC, SBP, DBP, and IFC. An association between improvement in adherence to the MedDiet and amelioration of IFC after 6-month follow-up was observed. High adherence to the MedDiet is associated with better status of MetS features, and better values of IFC. C1 [Montemayor, Sofia; Mascaro, Catalina M.; Ugarriza, Lucia; Llompart, Isabel; Tur, Josep A.; Bouzas, Cristina] Univ Balearic Isl IUNICS, Res Grp Community Nutr & Oxidat Stress, Palma De Mallorca 07122, Spain. [Montemayor, Sofia; Mascaro, Catalina M.; Ugarriza, Lucia; Llompart, Isabel; Tur, Josep A.; Bouzas, Cristina] Hlth Inst Balearic Isl IDISBA, Palma De Mallorca 07120, Spain. [Ugarriza, Lucia] Camp Redo Primary Hlth Care Ctr, Palma De Mallorca 07010, Spain. [Casares, Miguel] Red Asistencial Juaneda, Radiodiag Serv, Palma De Mallorca 07011, Spain. [Llompart, Isabel] Univ Hosp Son Espases, Clin Anal Serv, Palma De Mallorca 07120, Spain. [Abete, Itziar; Angeles Zulet, Maria; Tur, Josep A.; Bouzas, Cristina] Inst Salud Carlos III ISCIII, CIBEROBN Physiopathol Obes & Nutr CB12 03 30038, Madrid 28029, Spain. [Abete, Itziar; Angeles Zulet, Maria; Alfredo Martinez, J.] Univ Navarra, Ctr Nutr Res, Dept Nutr Food Sci & Physiol, Pamplona 31008, Spain. [Alfredo Martinez, J.] CEI UAM CSIC, IMDEA Food, Cardiomet Precis Nutr Program, Madrid 28049, Spain. C3 Hospital Universitari Son Espases; CIBER - Centro de Investigacion Biomedica en Red; CIBEROBN; University of Navarra; IMDEA Food Institute; Consejo Superior de Investigaciones Cientificas (CSIC) RP Tur, JA (通讯作者)，Univ Balearic Isl IUNICS, Res Grp Community Nutr & Oxidat Stress, Palma De Mallorca 07122, Spain.; Tur, JA (通讯作者)，Hlth Inst Balearic Isl IDISBA, Palma De Mallorca 07120, Spain.; Tur, JA (通讯作者)，Inst Salud Carlos III ISCIII, CIBEROBN Physiopathol Obes & Nutr CB12 03 30038, Madrid 28029, Spain. EM sofiamf16@gmail.com; c.mascaro@uib.es; luciaugarriza@gmail.com; casaresmiguel@gmail.com; isabel.11ompart@ssib.es; iabetego@unav.es; mazulet@unay.es; jalfredo.martinez@imdea.org; pep.tur@uib.es; cristina.bouzas@uib.es RI ; Abete, Itziar/H-4827-2017; Martínez, J./K-8709-2014; Tur, Josep/AAE-5748-2020; Zulet, M Angeles/H-1317-2017; Bouzas, Cristina/AAE-2069-2019 OI PÜRDİK TATIK, Gülnur/0009-0009-9392-5574; Abete, Itziar/0000-0002-6475-5387; Tur, Josep/0000-0002-6940-0761; Zulet, M Angeles/0000-0002-3926-0892; Montemayor, Sofía/0000-0001-7833-2118 FU Fundacio La Marato TV3 (Spain) [201630.10]; Instituto de Salud Carlos III through the CIBEROBN [CB12/03/30038]; Proyecto Intramural CIBER [OBN18PI03]; European Regional Development Fund; IDISBA grants; Spanish Ministry of Education; Directorate General of R+D of the Balearic Islands Government FX Fundacio La Marato TV3 (Spain) project ref. 201630.10. Instituto de Salud Carlos III through the CIBEROBN CB12/03/30038, and Proyecto Intramural CIBER OBN18PI03, which are co-funded by the European Regional Development Fund. Other funding received: IDISBA grants (FOLIUM, PRIMUS, SYNERGIA, and LIBERI). C.M.M. received an FPU PhD grant from the Spanish Ministry of Education. C.B. received a post-doctoral grant from the Directorate General of R+D of the Balearic Islands Government. The funding sponsors had no role in the design of the study, in the collection, analyses, or interpretation of the data; in the writing of the manuscript, or in the decision to publish the results. 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The aim of this study was to review systematically observational studies available regarding the relationship between food intakes and NAFLD. Methods: We searched Scopus, PubMed, and Cochrane Library databases to identify English observational studies on food groups, dietary patterns, and NAFLD. Cross-sectional, case-control and cohort studies were selected and then duplication, topic, type of study, study population, variables examined and quality of data reporting of the articles were evaluated. Results: We identified 2128 studies in the initial search, of which 33 were reviewed in full text and 7 articles were included in this systematic review. Intakes of red meat, fats, and sweets were high whereas consumption of whole grains, fruits and vegetables were less in NAFLD patients. Moreover, there was a positive association between the Western dietary pattern and the risk of NAFLD, while adherence to the Mediterranean diet was significantly associated with the severity of hepatic steatosis. Conclusion: Generally, different food group intakes and dietary patterns are associated with the progression of NAFLD and its risk factors. Because of the many limitations of available studies reviewed on this topic, more prospective studies are suggested. C1 [Mirmiran, Parvin; Amirhamidi, Zeynab; Ejtahed, Hanieh-Sadat; Bahadoran, Zahra] Shahid Beheshti Univ Med Sci, Res Inst Endocrine Sci, Nutr & Endocrine Res Ctr, Tehran, Iran. [Azizi, Fereidoun] Shahid Beheshti Univ Med Sci, Res Inst Endocrine Sci, Endocrine Res Ctr, Tehran, Iran. C3 Shahid Beheshti University Medical Sciences; Shahid Beheshti University Medical Sciences RP Bahadoran, Z (通讯作者)，Shahid Beheshti Univ Med Sci, Res Inst Endocrine Sci, Nutr & Endocrine Res Ctr, Tehran, Iran. EM z.bahadoran@endocrine.ac.ir RI Bahadoran, Zahra/V-2003-2019; Ejtahed, Hanieh-Sadat/AAH-4921-2021; Mirmiran, Parvin/V-1433-2019; Azizi, Fereidoun/ABD-4136-2021 OI Ejtahed, Hanieh-Sadat/0000-0002-6395-4915; Mirmiran, Parvin/0000-0003-2391-4924; Azizi, Fereidoun/0000-0002-6470-2517 FU Research Institute of Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran FX This study was funded by the Research Institute of Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran. The authors express to acknowledge the assistance given by Ms. Niloofar Shiva for critical editing of English grammar and syntax. 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Public Health PD AUG PY 2017 VL 46 IS 8 BP 1007 EP 1017 PG 11 WC Public, Environmental & Occupational Health WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI) SC Public, Environmental & Occupational Health GA FB7FN UT WOS:000406306600001 PM 28894701 DA 2026-02-02 ER PT J AU Vos, MB AF Vos, Miriam B. TI Nutrition, nonalcoholic fatty liver disease and the microbiome: recent progress in the field SO CURRENT OPINION IN LIPIDOLOGY LA English DT Review DE diet; fructose; microbiome; nonalcoholic steatohepatitis ID NECROSIS-FACTOR-ALPHA; HEPATIC STEATOSIS; INTESTINAL PERMEABILITY; DIETARY FRUCTOSE; GUT MICROBIOTA; OMEGA-3-FATTY-ACIDS; TRANSPORTERS; ANTIBIOTICS; ENDOTOXEMIA; CHOLESTEROL AB Purpose of reviewNonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide and it has overlapping pathogenesis with diabetes and cardiovascular disease. Reviewed here are recent advances in understanding the contribution of diet and selected nutrients to NAFLD.Recent findingsTo understand the effect of diet, the microbiome must be considered because it is the interface of diet and the liver. Early studies suggest that the characteristic of the microbiota is altered in NAFLD. Fructose is a lipogenic carbohydrate that contributes to insulin resistance, hypertriglyceridemia and appears to be associated with the severity of NAFLD. Fructose absorption and malabsorption may alter the microbiota and could be mediating effects on the liver. Lipids also have potent microbiome interactions and could contribute to the benefit of diets emphasizing lipid changes. Several new studies demonstrate that the Mediterranean diet and lifestyle change' are effective in modestly improving NAFLD. A new study of lifestyle' in children showed simultaneous improvement in cardiovascular disease risk measurements and hepatic steatosis.SummaryCurrent data supports limiting sugar in the diet and lifestyle change' as a first-line treatment for NAFLD; however, the benefits from these appear to be modest. The effects of diet on the liver are mediated through the microbiome and expansion of research in this area is needed. C1 [Vos, Miriam B.] Emory Univ, Atlanta, GA 30322 USA. [Vos, Miriam B.] Childrens Healthcare Atlanta, Atlanta, GA USA. C3 Emory University; Children's Healthcare of Atlanta (CHOA) RP Vos, MB (通讯作者)，2015 Uppergate Dr NE, Atlanta, GA 30030 USA. 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Opin. Lipidology PD FEB PY 2014 VL 25 IS 1 BP 61 EP 66 DI 10.1097/MOL.0000000000000043 PG 6 WC Biochemistry & Molecular Biology; Endocrinology & Metabolism; Peripheral Vascular Disease WE Science Citation Index Expanded (SCI-EXPANDED) SC Biochemistry & Molecular Biology; Endocrinology & Metabolism; Cardiovascular System & Cardiology GA 286AV UT WOS:000329437800009 PM 24366230 OA Green Submitted DA 2026-02-02 ER PT J AU Kontogianni, MD Tileli, N Margariti, A Georgoulis, M Deutsch, M Tiniakos, D Fragopoulou, E Zafiropoulou, R Manios, Y Papatheodoridis, G AF Kontogianni, Meropi D. Tileli, Nafsika Margariti, Aikaterini Georgoulis, Michael Deutsch, Melanie Tiniakos, Dina Fragopoulou, Elisabeth Zafiropoulou, Rodessa Manios, Yannis Papatheodoridis, George TI Adherence to the Mediterranean diet is associated with the severity of non-alcoholic fatty liver disease SO CLINICAL NUTRITION LA English DT Article DE Mediterranean diet; Inflammatory markers; Transient elastography; Liver biopsy ID INSULIN-RESISTANCE; OLIVE OIL; RISK; STEATOHEPATITIS; EPIDEMIOLOGY; CONSUMPTION; PREVALENCE; VALIDITY; OBESITY; PLASMA AB Background & aims: Nutrition has been proposed as a potential environmental factor affecting the risk of non-alcoholic fatty liver disease (NAFLD). In the present study, the impact of adherence to the Mediterranean diet (MD) on the presence and severity of NAFLD was explored. Methods: Seventy-three consecutive adult patients with recent NAFLD diagnosis were included. Adherence to the MD was estimated with MedDietScore. Demographic and anthropometric data, body composition analysis and several biochemical and inflammatory markers were estimated. Liver stiffness measurements by transient elastography were available in 58 patients and liver biopsies in 34 patients. Fifty-eight patients were matched with 58 healthy controls in terms of age, sex and body mass index. Results: MedDietScore was negatively correlated to patients' serum alanine aminotransferase (p = 0.03) and insulin levels (p = 0.001), insulin resistance index (p = 0.005) and severity of steatosis (p = 0.006) and positively to serum adiponectin levels (p = 0.04). Patients with non-alcoholic steatohepatitis (NASH) exhibited lower adherence to MD (29.3 +/- 3.2 vs. 34.1 +/- 4.4, p = 0.004) compared to those with simple fatty liver. Logistic regression analysis revealed that one unit increase in the MedDietScore was associated with 36% lower likelihood of having NASH (odds ratio: 0.64, 95% confidence interval: 0.45-0.92), after adjusting for sex and abdominal fat level. No difference in the MedDietScore was observed between patients and controls. Conclusions: Higher adherence to the Mediterranean diet is not associated with lower likelihood of having NAFLD, but it is associated with less degree of insulin resistance and less severe liver disease among patients with NAFLD. (C) 2013 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved. C1 [Kontogianni, Meropi D.; Tileli, Nafsika; Georgoulis, Michael; Fragopoulou, Elisabeth; Manios, Yannis] Harokopio Univ, Dept Nutr & Dietet, Athens 17671, Greece. [Margariti, Aikaterini; Deutsch, Melanie; Zafiropoulou, Rodessa; Papatheodoridis, George] Univ Athens, Sch Med, Hippokrat Hosp Athens, Dept Internal Med 2, GR-10679 Athens, Greece. [Tiniakos, Dina] Univ Athens, Sch Med, Lab Histol & Embryol, Athens, Greece. C3 Harokopio University Athens; National & Kapodistrian University of Athens; National & Kapodistrian University of Athens RP Kontogianni, MD (通讯作者)，Harokopio Univ, Dept Nutr & Dietet, El Venizelou 70, Athens 17671, Greece. EM mkont@hua.gr; nafsika.tileli@gmail.com; katerina.marg@gmail.com; mihalis.georgoulis@gmail.com; meladeut@gmail.com; dtiniak@med.uoa.gr; efragop@hua.gr; rodza@mycosmos.gr; manios@hua.gr; gepapath@med.uoa.gr RI Fragopoulou, Elizabeth/AAN-2050-2021; Georgoulis, Michael/AAO-2167-2021; Tiniakos, Dina/AAA-5708-2020; Maria Melanie, Deutsch/I-3279-2019; Manios, Yannis/AAM-8953-2021; Kontogianni, Meropi/AAN-6530-2021; Papatheodoridis, George/A-4603-2008 OI Georgoulis, Michael/0000-0003-4619-2100; Maria Melanie, Deutsch/0000-0002-3410-8226; Manios, Yannis/0000-0001-6486-114X; Kontogianni, Meropi/0000-0003-3168-8867; Papatheodoridis, George/0000-0002-3518-4060 FU Hellenic Foundation of Gastroenterology 82 Nutrition FX This research was supported financially by a research grant from the Hellenic Foundation of Gastroenterology 82 Nutrition. The Foundation had no involvement in the study's design, conduction or in the manuscript's writing. 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Nutr. PD AUG PY 2014 VL 33 IS 4 BP 678 EP 683 DI 10.1016/j.clnu.2013.08.014 PG 6 WC Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Nutrition & Dietetics GA AL0IJ UT WOS:000338810300017 PM 24064253 DA 2026-02-02 ER PT J AU Barrea, L Verde, L Savastano, S Colao, A Muscogiuri, G AF Barrea, Luigi Verde, Ludovica Savastano, Silvia Colao, Annamaria Muscogiuri, Giovanna TI Adherence to Mediterranean Diet: Any Association with NAFLD? SO ANTIOXIDANTS LA English DT Article DE Mediterranean diet; non-alcoholic liver disease; obesity; diet; nutrition; VAI; FLI; HoMA-IR ID FATTY LIVER-DISEASE; INSULIN-RESISTANCE; RESVERATROL; GLUCOSE; INDIVIDUALS; POLYPHENOLS; CONSUMPTION; MICROBIOTA; SEVERITY AB Oxidative stress is considered one of the main determinants in the pathophysiology of non-alcoholic fatty liver disease (NAFLD) and obesity. The alterations of oxidant/antioxidant balance are related to chronic impairment of metabolism leading to mitochondrial dysfunction. Increased oxidative stress also triggers hepatocytes stress pathways, leading to inflammation and contributing to the progression of non-alcoholic steatohepatitis (NASH). Currently, the first-line therapeutic treatment of NAFLD is based on lifestyle interventions, suggesting the Mediterranean Diet (MD) as a preferable nutritional approach due to its antioxidant properties. However, it is still debated if adherence to MD could have a role in determining the risk of developing NAFLD directly or indirectly through its effect on weight. We enrolled 336 subjects (aged 35.87 & PLUSMN; 10.37 years; BMI 31.18 & PLUSMN; 9.66 kg/m(2)) assessing anthropometric parameters, lifestyle habits, metabolic parameters (fasting plasma glucose, fasting plasma insulin, triglycerides (TG), total cholesterol, low-density (LDL) and high-density lipoprotein (HDL) cholesterol, alanine transaminase (ALT), aspartate aminotransferase (AST), and & gamma;-glutamyltransferase (& gamma;GT), cardio-metabolic indices [Homeostatic Model Assessment Insulin Resistance (HoMA-IR), visceral adipose index (VAI) and fatty liver index (FLI)] and adherence to MD [with the PREvencion con DIetaMEDiterranea (PREDIMED) questionnaire]. Subjects with NAFLD had significantly higher anthropometric parameters, cardio-metabolic indices and lower adherence to MD than subjects without NAFLD. In a multiple regression analysis, PREDIMED score was the main predictor of FLI (p < 0.001) and came in first, followed by HoMA-IR, while VAI was not a predictor. A PREDIMED score value of <6 could serve as a threshold to identify patients who are more likely to have NAFLD (p < 0.001). In conclusion, high adherence to MD resulted in a lower risk of having NAFLD. Adherence to MD could have a direct role on the risk of developing NAFLD, regardless of visceral adipose tissue. C1 [Barrea, Luigi] Univ Telemat Pegaso, Ctr Direzionale Isola F2, Dipartimento Sci Umanist, Via Porzio, I-80143 Naples, Italy. [Verde, Ludovica; Savastano, Silvia; Colao, Annamaria; Muscogiuri, Giovanna] Univ Napoli Federico II, Ctr Italiano cura & Benessere Paziente Obes CIBO, Dipartimento Med Clin & Chirurg, Unita Endocrinol Diabetol & Androl, Via Sergio Pansini 5, I-80131 Naples, Italy. [Verde, Ludovica] Univ Naples Federico II, Dept Publ Hlth, Via Sergio Pansini 5, I-80131 Naples, Italy. [Savastano, Silvia; Colao, Annamaria; Muscogiuri, Giovanna] Univ Napoli Federico II, Dipartimento Med Clin & Chirurg, Unita Endocrinol Diabetol & Androl, Via Sergio Pansini 5, I-80131 Naples, Italy. [Colao, Annamaria; Muscogiuri, Giovanna] Univ Federico II, Cattedra Unesco Educ Salute E Allo Sviluppo Sosten, I-80131 Naples, Italy. C3 Pegaso Online University; University of Naples Federico II; University of Naples Federico II; University of Naples Federico II; University of Naples Federico II RP Muscogiuri, G (通讯作者)，Univ Napoli Federico II, Ctr Italiano cura & Benessere Paziente Obes CIBO, Dipartimento Med Clin & Chirurg, Unita Endocrinol Diabetol & Androl, Via Sergio Pansini 5, I-80131 Naples, Italy.; Muscogiuri, G (通讯作者)，Univ Napoli Federico II, Dipartimento Med Clin & Chirurg, Unita Endocrinol Diabetol & Androl, Via Sergio Pansini 5, I-80131 Naples, Italy.; Muscogiuri, G (通讯作者)，Univ Federico II, Cattedra Unesco Educ Salute E Allo Sviluppo Sosten, I-80131 Naples, Italy. EM giovanna.muscogiuri@unina.it RI Barrea, Luigi/K-6551-2016; Verde, Ludovica/AHB-4097-2022; Savastano, Silvia/K-6546-2016; Colao, Annamaria/A-7671-2011; Muscogiuri, Giovanna/K-5817-2016 OI Barrea, Luigi/0000-0001-9054-456X; Verde, Ludovica/0000-0002-4583-8283; CR Aller R, 2015, NUTR HOSP, V32, P2518 Amato MC, 2011, LIPIDS HEALTH DIS, V10, DOI 10.1186/1476-511X-10-183 Amato MC, 2014, INT J ENDOCRINOL, V2014, DOI 10.1155/2014/730827 Amer Diabet Assoc, 2021, DIABETES CARE, V44, pS15, DOI 10.2337/dc21-S002 Martínez-González MA, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0043134 [Anonymous], 2000, Diagnostic and statistical manual of mental disorders: DSM-5, V4th, DOI [DOI 10.1176/APPI.BOOKS.9780890425596, 10.1176/appi.books.9780890425596] Bahcecioglu Ibrahim Halil, 2010, Vet Med Int, V2010, DOI 10.4061/2010/262179 Baratta F, 2017, AM J GASTROENTEROL, V112, P1832, DOI 10.1038/ajg.2017.371 Barrea L, 2022, FRONT NUTR, V9, DOI 10.3389/fnut.2022.944200 Barrea L, 2018, ARCH TOXICOL, V92, P1831, DOI 10.1007/s00204-018-2193-0 Barrea L, 2017, OXID MED CELL LONGEV, V2017, DOI 10.1155/2017/6101254 Barrea L, 2017, CLIN NUTR, V36, P293, DOI 10.1016/j.clnu.2015.12.007 Bedogni G, 2006, BMC GASTROENTEROL, V6, DOI 10.1186/1471-230X-6-33 Chalasani N, 2018, HEPATOLOGY, V67, P328, DOI [10.1002/hep.29367, 10.1038/s42255-021-00344-4] Chen SH, 2015, DIGEST LIVER DIS, V47, P226, DOI 10.1016/j.dld.2014.11.015 Della Corte C, 2017, NUTRITION, V39-40, P8, DOI 10.1016/j.nut.2017.02.008 Donnelly KL, 2005, J CLIN INVEST, V115, P1343, DOI 10.1172/JCI200523621 Faghihzadeh F, 2014, NUTR RES, V34, P837, DOI 10.1016/j.nutres.2014.09.005 Hasegawa T, 2001, ALIMENT PHARM THERAP, V15, P1667, DOI 10.1046/j.1365-2036.2001.01083.x Queipo-Ortuño MI, 2012, AM J CLIN NUTR, V95, P1323, DOI 10.3945/ajcn.111.027847 Juanola O, 2021, INT J ENV RES PUB HE, V18, DOI 10.3390/ijerph18105227 Kontogianni MD, 2014, CLIN NUTR, V33, P678, DOI 10.1016/j.clnu.2013.08.014 Levey AS, 2009, ANN INTERN MED, V150, P604, DOI 10.7326/0003-4819-150-9-200905050-00006 Marchesini G, 2016, J HEPATOL, V64, P1388, DOI 10.1016/j.jhep.2015.11.004 MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883 Mouzaki M, 2013, HEPATOLOGY, V58, P120, DOI 10.1002/hep.26319 Muscogiuri G, 2022, CURR OBES REP, V11, P287, DOI 10.1007/s13679-022-00481-1 Muscogiuri G, 2019, HORM-INT J ENDOCRINO, V18, P75, DOI 10.1007/s42000-018-0090-9 Nani A, 2021, MOLECULES, V26, DOI 10.3390/molecules26040985 National Cholesterol Education Program, ATP 3 GUID GLANC QUI Paniagua JA, 2007, J AM COLL NUTR, V26, P434, DOI 10.1080/07315724.2007.10719633 Valdecantos MP, 2010, REDOX REP, V15, P207, DOI 10.1179/135100010X12826446921464 Pintó X, 2019, J NUTR, V149, P1920, DOI 10.1093/jn/nxz147 Potter JJ, 2013, LIVER INT, V33, P677, DOI 10.1111/liv.12122 Prates RE, 2016, DIABETES RES CLIN PR, V116, P205, DOI 10.1016/j.diabres.2016.03.019 Promrat K, 2010, HEPATOLOGY, V51, P121, DOI 10.1002/hep.23276 Rodriguez-Ramiro I, 2016, P NUTR SOC, V75, P47, DOI 10.1017/S0029665115004218 Ross R, 2020, NAT REV ENDOCRINOL, V16, P177, DOI 10.1038/s41574-019-0310-7 Ryan MC, 2013, J HEPATOL, V59, P138, DOI 10.1016/j.jhep.2013.02.012 Schattenberg JM, 2023, COMMUN MED-LONDON, V3, DOI 10.1038/s43856-022-00228-y Trovato FM, 2016, WORLD J HEPATOL, V8, P1459, DOI 10.4254/wjh.v8.i33.1459 Trovato FM, 2015, CLIN NUTR, V34, P86, DOI 10.1016/j.clnu.2014.01.018 Van De Wier B, 2017, CRIT REV FOOD SCI, V57, P834, DOI 10.1080/10408398.2014.952399 Verde L, 2023, ANTIOXIDANTS-BASEL, V12, DOI 10.3390/antiox12010018 VOGELBERG KH, 1980, HORM METAB RES, V12, P688, DOI 10.1055/s-2007-999233 Watt MJ, 2019, ENDOCR REV, V40, P1367, DOI 10.1210/er.2019-00034 Wong VWS, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0062885 Younossi Z, 2018, NAT REV GASTRO HEPAT, V15, P11, DOI 10.1038/nrgastro.2017.109 Younossi ZM, 2023, HEPATOLOGY, V77, P1335, DOI 10.1097/HEP.0000000000000004 NR 49 TC 16 Z9 17 U1 0 U2 6 PU MDPI PI BASEL PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND EI 2076-3921 J9 ANTIOXIDANTS-BASEL JI Antioxidants PD JUL PY 2023 VL 12 IS 7 AR 1318 DI 10.3390/antiox12071318 PG 14 WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science & Technology WE Science Citation Index Expanded (SCI-EXPANDED) SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science & Technology GA N1SE4 UT WOS:001034885900001 PM 37507858 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Abbate, JM Macrì, F Capparucci, F Iaria, C Briguglio, G Cicero, L Salvo, A Arfuso, F Ieni, A Piccione, G Lanteri, G AF Abbate, Jessica M. Macri, Francesco Capparucci, Fabiano Iaria, Carmelo Briguglio, Giovanni Cicero, Luca Salvo, Andrea Arfuso, Francesca Ieni, Antonio Piccione, Giuseppe Lanteri, Giovanni TI Administration of Protein Hydrolysates from Anchovy (Engraulis Encrasicolus) Waste for Twelve Weeks Decreases Metabolic Dysfunction-Associated Fatty Liver Disease Severity in ApoE-/-Mice SO ANIMALS LA English DT Article DE hydrolysates; anchovy; MAFLD; ApoE-deficient mice ID APOLIPOPROTEIN-E; NONALCOHOLIC STEATOHEPATITIS; MEDITERRANEAN DIET; HEPATIC STEATOSIS; ACID-COMPOSITION; PEPTIDES; SERUM; N-3; ATHEROSCLEROSIS; SUPPLEMENTATION AB Simple Summary Metabolic dysfunction-associated fatty liver disease (MAFLD) is an increasing concern worldwide. It currently represents the main cause of chronic liver disease in humans in Western countries. Nutritional strategies based on fish-rich diets are considered helpful in the prevention of MAFLD, and are also thought to be beneficial for human health. In particular, cholesterol- and triacylglycerol-lowering effects are associated with fish-derived proteins or hydrolysates. Our findings suggest that supplementing the diet with 10% (w/w) anchovy protein hydrolysates has an anti-obesity effect together with an improvement in lipid metabolism and a reduction in liver fat content and high-fat diet-induced liver disease. By virtue of their nutritional value and functional proprieties, anchovy by-product protein hydrolysates may be an efficient nutritional strategy in MAFLD prevention and treatment. Metabolic dysfunction-associated fatty liver disease (MAFLD) includes several diseases, ranging from simple steatosis to steatohepatitis, fibrosis and cirrhosis. Fish-rich diets are considered helpful in the prevention of MAFLD, and the enzymatic hydrolysis of fish waste has been explored as a means of obtaining high-value protein hydrolysates, which have been proven to exert beneficial bioactivities including anti-obesity and hypocholesterol effects. This study aimed to assess the effect of the administration of protein hydrolysates from anchovy waste (APH) for 12 weeks on attenuated high-fat diet-induced MAFLD in apolipoprotein E-knockout mice (ApoE(-/-)). Thirty ApoE(-/-) mice were divided into two groups (n = 15/group) and fed a high-fat diet (HFD), with and without the addition of 10% (w/w) APH. After 12 weeks, serum and hepatic lipid profiles, hepatic enzyme activities, liver histology and immunohistochemistry were analyzed to assess hepatic steatosis, inflammation and fibrosis. Twelve-weeks on a 10% (w/w) APH diet reduces total cholesterol and triglyceride serum levels, hepatic enzyme activity and hepatic triacylglycerol content (p < 0.0001), and results in a reduction in hepatic fat accumulation and macrophage recruitment (p < 0.0001). The results suggest that a 10% APH diet has an anti-obesity effect, with an improvement in lipid metabolism, hepatic steatosis and liver injury as a result of a high-fat diet. Protein hydrolysates from fish waste may represent an efficient nutritional strategy in several diseases, and their use as nutraceuticals is worthy of future investigation. C1 [Abbate, Jessica M.; Macri, Francesco; Arfuso, Francesca; Piccione, Giuseppe; Lanteri, Giovanni] Univ Messina, Dept Vet Sci, I-98168 Messina, Italy. [Capparucci, Fabiano; Iaria, Carmelo] Univ Messina, Dept Chem Biol Pharmaceut & Environm Sci, I-98166 Messina, Italy. [Cicero, Luca] Zooprophylact Inst Sicily A Mirri IZS, I-90129 Palermo, Italy. [Salvo, Andrea] Univ Roma La Sapienza, Dept Pharmaceut Chem & Technol, I-00185 Rome, Italy. [Ieni, Antonio] Univ Messina, Dept Human Pathol Adult & Evolut Age Gaetano Barr, Sect Pathol, I-98125 Messina, Italy. C3 University of Messina; University of Messina; Sapienza University Rome; University of Messina RP Capparucci, F (通讯作者)，Univ Messina, Dept Chem Biol Pharmaceut & Environm Sci, I-98166 Messina, Italy. EM jabbate@unime.it; fmacri@unime.it; fcapparucci@unime.it; ciaria@unime.it; giobri9@gmail.com; cicero.luca@libero.it; andrea.salvo@uniroma1.it; farfuso@unime.it; antonio.ieni@unime.it; giuseppe.piccione@unime.it; glanteri@unime.it RI Abbate, Jessica Maria/AAZ-9872-2020; SALVO, Anea/J-8556-2016; cicero, Luca/P-8166-2015; IARIA, CARMELO/F-1509-2018; Abbate, Jessica Maria/ABP-8507-2022; IENI, ANTONIO/AAC-7265-2019; Piccione, Giuseppe/P-3394-2015; Capparucci, Fabiano/AAK-7345-2020; lanteri, giovanni/ABP-8507-2022; Macrì, Francesco/L-3089-2015 OI Abbate, Jessica Maria/0000-0003-4532-9697; ARFUSO, FRANCESCA/0000-0001-6139-2691; SALVO, Anea/0000-0002-0519-5084; cicero, Luca/0000-0003-4386-7723; IARIA, CARMELO/0000-0001-7930-8881; Abbate, Jessica Maria/0000-0003-4532-9697; IENI, ANTONIO/0000-0003-2878-3572; lanteri, giovanni/0000-0002-3436-2814; Capparucci, Fabiano/0000-0003-1807-406X; FU Ministero delle Politiche Agricole, Alimentari e Forestali (MIPAAF) [7467] FX This research was funded by Ministero delle Politiche Agricole, Alimentari e Forestali (MIPAAF), Approved no. D.D. n. 7467, 28/12/2017. 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Papadaki, Angeliki Nolen-Doerr, Eric Boutari, Chrysoula Mantzoros, Christos S. TI The effect of dietary patterns on non-alcoholic fatty liver disease diagnosed by biopsy or magnetic resonance in adults: a systematic review of randomised controlled trials SO METABOLISM-CLINICAL AND EXPERIMENTAL LA English DT Review DE Dietary patterns; Non-alcoholic fatty liver disease; Disease progression; Randomised controlled trials; Systematic review ID HEPATIC STEATOSIS; PHYSICAL-ACTIVITY; PREVALENCE; ASSOCIATION; BIOMARKERS; NAFLD AB Adhering to specific dietary patterns might hold promise as a lifestyle modification treatment of non-alcoholic fatty liver disease (NAFLD). The aim of this systematic review was to examine the effect of dietary patterns on changes in hepatic fat content, liver enzymes and metabolic syndrome components. We searched Pubmed, Embase, CINAHL and Web of Science for randomised controlled trials published in English until April 2020, comparing a specific dietary pattern with no treatment, usual care, or a different diet in adults with NAFLD. Studies were included if NAFLD had been diagnosed using biopsy, magnetic resonance imaging, or proton magnetic resonance spectroscopy. Data from three trials in adults with NAFLD but without diabetes (n = 128; mean age 49.9 +/- 5.0 years, range 42-55 years) were included in the qualitative synthesis; across them, risk of bias was considered low, unclear and high for 33%, 38% and 29% of domains, respectively. There was moderate evidence that a low-carbohydrate, compared to a low-calorie diet (-27%, P = 0.008, one study, n = 18) and the Mediterranean, compared to a low-fat, high-carbohydrate diet (-4.4%, P = 0.030, one study, n = 12) result in greater reductions in hepatic fat content, but no such evidence was found for the Fatty Liver in Obesity dietary pattern (based on the principles of the Mediterranean diet), compared to the American Heart Association diet (-0.6%, P = 0.706, one study, n= 98). No between-group differences were reported for other outcomes across studies. A post hoc analysis, including two eligible studies assessing the effect of the Mediterranean, compared to a low-fat diet, irrespective of baseline presence of diabetes, showed strong evidence that the Mediterranean diet reduces hepatic fat content (-4.1%, 95% CI = -5.8 to -2.3, P < 0.001; I-2 = 0%) and triglyceride concentrations ( -16.9 mg/dL, 95% CI = -26.3 to -7.7, P < 0.001;I-2 = 0%). Well-designed, adequately powered and rigorous randomised controlled trials are needed to provide robust evidence on the effect of these dietary patterns, but also other whole dietary approaches, on NAFLD progression. (C) 2022 Elsevier Inc. All rights reserved. C1 [Angelidi, Angeliki M.; Papadaki, Angeliki; Nolen-Doerr, Eric; Boutari, Chrysoula; Mantzoros, Christos S.] Harvard Med Sch, Beth Israel Deaconess Med Ctr, Dept Med, Div Endocrinol, Boston, MA USA. [Angelidi, Angeliki M.; Mantzoros, Christos S.] Boston VA Healthcare Syst, Dept Endocrinol, Boston, MA USA. [Papadaki, Angeliki] Univ Bristol, Ctr Exercise Nutr & Hlth Sci, Sch Policy Studies, 8 Priory Rd, Bristol BS8 1TZ, Avon, England. C3 Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Beth Israel Deaconess Medical Center; Harvard University; Harvard University Medical Affiliates; US Department of Veterans Affairs; Veterans Health Administration (VHA); VA Boston Healthcare System; University of Bristol RP Papadaki, A (通讯作者)，Univ Bristol, Ctr Exercise Nutr & Hlth Sci, Sch Policy Studies, 8 Priory Rd, Bristol BS8 1TZ, Avon, England. EM angeliki.papadaki@bristol.ac.uk RI ; Boutari, Chrysoula/ABW-6757-2022; Mantzoros, Christos/Y-2902-2019; Angelidi, Angeliki/AEZ-2917-2022 OI Papadaki, Angeliki/0000-0002-5728-3975; Boutari, Chrysoula/0000-0002-0053-2440; CR Marin-Alejandre BA, 2019, NUTRIENTS, V11, DOI 10.3390/nu11102543 Bach-Faig A, 2011, PUBLIC HEALTH NUTR, V14, P2274, DOI 10.1017/S1368980011002515 Bland JM, 2015, AM J CLIN NUTR, V102, P991, DOI 10.3945/ajcn.115.119768 Browning JD, 2011, AM J CLIN NUTR, V93, P1048, DOI 10.3945/ajcn.110.007674 Chalasani N, 2018, HEPATOLOGY, V67, P328, DOI [10.1002/hep.29367, 10.1038/s42255-021-00344-4] Chen GL, 2016, INT J MOL SCI, V17, DOI 10.3390/ijms17091379 Di Minno MND, 2012, WORLD J GASTROENTERO, V18, P5839, DOI 10.3748/wjg.v18.i41.5839 European Association for the Study of the Liver (EASL), 2016, J Hepatol, V64, P1388, DOI 10.1016/j.jhep.2015.11.004 Zadeh SH, 2021, J GASTROEN HEPATOL, V36, P1470, DOI 10.1111/jgh.15363 Higgins JPT, 2003, BMJ-BRIT MED J, V327, P557, DOI 10.1136/bmj.327.7414.557 Higgins JPT, 2011, BMJ-BRIT MED J, V343, DOI 10.1136/bmj.d5928 Houttu V, 2021, FRONT NUTR, V8, DOI 10.3389/fnut.2021.716783 Hu FB, 2002, CURR OPIN LIPIDOL, V13, P3, DOI 10.1097/00041433-200202000-00002 Kani AH, 2013, HEPAT MON, V13, DOI 10.5812/hepatmon.10943 Kanwal F, 2021, METABOLISM, V122, DOI 10.1016/j.metabol.2021.154822 Katsagoni CN, 2017, METABOLISM, V68, P119, DOI 10.1016/j.metabol.2016.12.006 Kenneally S, 2017, BMJ OPEN GASTROENTER, V4, DOI 10.1136/bmjgast-2017-000139 Kinner S, 2016, DIGEST DIS SCI, V61, P1337, DOI 10.1007/s10620-016-4037-1 Lee DH, 2017, CLIN MOL HEPATOL, V23, P290, DOI 10.3350/cmh.2017.0042 Li Q, 2018, WORLD J HEPATOL, V10, P530, DOI 10.4254/wjh.v10.i8.530 Liu WS, 2015, CURR DRUG TARGETS, V16, P1301, DOI 10.2174/1389450116666150427155342 López-Velázquez JA, 2014, ANN HEPATOL, V13, P166, DOI 10.1016/S1665-2681(19)30879-8 Lu WX, 2016, GASTROENT RES PRACT, V2016, DOI 10.1155/2016/1459790 Mouzaki M, 2012, J CLIN GASTROENTEROL, V46, P457, DOI 10.1097/MCG.0b013e31824cf51e Noureddin M, 2013, HEPATOLOGY, V58, P1930, DOI 10.1002/hep.26455 Page MJ, 2021, BMJ-BRIT MED J, V372, DOI [10.1136/bmj.n71, 10.1186/s40900-023-00424-7] Papadaki A, 2020, NUTRIENTS, V12, DOI 10.3390/nu12113342 Properzi C, 2018, HEPATOLOGY, V68, P1741, DOI 10.1002/hep.30076 Riazi K, 2019, NUTRIENTS, V11, DOI 10.3390/nu11122878 Romero-Gómez M, 2017, J HEPATOL, V67, P829, DOI 10.1016/j.jhep.2017.05.016 Rosqvist F, 2020, FRONT NUTR, V7, DOI 10.3389/fnut.2020.613221 Ryan MC, 2013, J HEPATOL, V59, P138, DOI 10.1016/j.jhep.2013.02.012 Saeed N, 2019, NUTRIENTS, V11, DOI 10.3390/nu11123064 Tana C, 2019, INT J ENV RES PUB HE, V16, DOI 10.3390/ijerph16173104 Targher G, 2007, DIABETES CARE, V30, P1212, DOI 10.2337/dc06-2247 Targher G, 2020, GUT, V69, P1691, DOI 10.1136/gutjnl-2020-320622 Watanabe M, 2020, OBES REV, V21, DOI 10.1111/obr.13024 Willebrords J, 2015, PROG LIPID RES, V59, P106, DOI 10.1016/j.plipres.2015.05.002 Younossi ZM, 2019, J HEPATOL, V70, P531, DOI 10.1016/j.jhep.2018.10.033 Younossi ZM, 2004, CLIN GASTROENTEROL H, V2, P262, DOI 10.1016/S1542-3565(04)00014-X Younossi ZM, 2016, HEPATOLOGY, V64, P73, DOI 10.1002/hep.28431 Zelber-Sagi S, 2011, WORLD J GASTROENTERO, V17, P3377, DOI 10.3748/wjg.v17.i29.3377 Zhao HM, 2020, FRONT NUTR, V7, DOI 10.3389/fnut.2020.593735 NR 43 TC 28 Z9 31 U1 1 U2 15 PU W B SAUNDERS CO-ELSEVIER INC PI PHILADELPHIA PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA SN 0026-0495 EI 1532-8600 J9 METABOLISM JI Metab.-Clin. Exp. PD APR PY 2022 VL 129 AR 155136 DI 10.1016/j.metabol.2022.155136 EA JAN 2022 PG 9 WC Endocrinology & Metabolism WE Science Citation Index Expanded (SCI-EXPANDED) SC Endocrinology & Metabolism GA YW9GG UT WOS:000753718800007 PM 35032545 OA Green Submitted DA 2026-02-02 ER PT J AU Franco, I Bianco, A Mirizzi, A Campanella, A Bonfiglio, C Sorino, P Notarnicola, M Tutino, V Cozzolongo, R Giannuzzi, V Aballay, LR Buongiorno, C Bruno, I Osella, AR AF Franco, Isabella Bianco, Antonella Mirizzi, Antonella Campanella, Angelo Bonfiglio, Caterina Sorino, Paolo Notarnicola, Maria Tutino, Valeria Cozzolongo, Raffaele Giannuzzi, Vito Aballay, Laura R. Buongiorno, Claudia Bruno, Irene Osella, Alberto R. TI Physical Activity and Low Glycemic Index Mediterranean Diet: Main and Modification Effects on NAFLD Score. Results from a Randomized Clinical Trial SO NUTRIENTS LA English DT Article DE physical activity; non-alcoholic fatty liver disease; diet; controlled attenuation parameter (CAP); aerobic exercise; combined exercise ID FATTY LIVER-DISEASE; CONTROLLED ATTENUATION PARAMETER; LIFE-STYLE INTERVENTIONS; HEPATIC STEATOSIS; RESISTANCE EXERCISE; WEIGHT-LOSS; NONINVASIVE ASSESSMENT; EPIDEMIOLOGY; INDIVIDUALS; POPULATION AB Background: Non-Alcoholic Fatty Liver Disease (NAFLD) is the most common chronic liver disease worldwide, and lifestyle modification is the current standard treatment. The aim of the study was to estimate the effect of two different physical activity (PA) programs, a Low Glycemic Index Mediterranean Diet (LGIMD), and their combined effect on the NAFLD score as measured by FibroScan(R). Methods: Moderate or severe NAFLD subjects (n = 144) were randomly assigned to six intervention arms during three months. Interventions arms were a control diet, LGIMD, aerobic activity program (PA1), combined activity program (PA2), and LGIMD plus PA1 or LGIMD plus PA2. The data were compared at baseline, at 45 days, and at 90 days. Analysis of variance was performed under the intention-to-treat principle. Results: There was a statistically significant reduction in the NAFLD score after 45 days of treatment in every working arm except for Arm 1 (control diet). After 90 days, the best results were shown by the intervention arms in which LGIMD was associated with PA: LGIMD plus PA1 (-61.56 95% CI -89.61, -33.50) and LGIMD plus PA2 (-38.15 95% CI -64.53, -11.77). Conclusion: All treatments were effective to reduce NAFLD scores, but LGIMD plus PA1 was the most efficient. C1 [Franco, Isabella; Bianco, Antonella; Mirizzi, Antonella; Campanella, Angelo; Bonfiglio, Caterina; Sorino, Paolo; Buongiorno, Claudia; Bruno, Irene; Osella, Alberto R.] S de Bellis Res Hosp, Natl Inst Gastroenterol, Lab Epidemiol & Biostat, Via Turi 27, I-70013 Castellana Grotte, Italy. [Notarnicola, Maria; Tutino, Valeria] S de Bellis Res Hosp, Natl Inst Gastroenterol, Lab Nutr Biochem, Via Turi 27, I-70013 Castellana Grotte, Italy. [Cozzolongo, Raffaele; Giannuzzi, Vito] S de Bellis Res Hosp, Natl Inst Gastroenterol, Dept Gastroenterol, Via Turi 27, I-70013 Castellana Grotte, Italy. [Aballay, Laura R.] Univ Nacl Cordoba, Fac Med Sci, Enrique Barros Pabellon Biol Celular, Human Nutr Res Ctr CenINH,Sch Nutr, Ciudad Univ,X5000, Cordoba, Argentina. C3 National University of Cordoba RP Osella, AR (通讯作者)，S de Bellis Res Hosp, Natl Inst Gastroenterol, Lab Epidemiol & Biostat, Via Turi 27, I-70013 Castellana Grotte, Italy. EM isabella.franco@irccsdebellis.it; antonella.bianco@irccsdebellis.it; antonella.mirizzi@irccsdebellis.it; angelocampanella7@gmail.com; catia.bonfiglio@irccsdebellis.it; paolosorino96@libero.it; maria.notarnicola@irccsdebellis.it; valeria.tutino@irccsdebellis.it; raffaelecln1@alice.it; v55567@alice.it; laballay@fcm.unc.edu.ar; buongiorno.claudia@gmail.com; irenebrunodiet@gmail.com; arosella@irccsdebellis.it RI cozzolongo, raffaele/ABH-5696-2020; Osella, Alberto/M-6888-2014; Sorino, Paolo/JFS-3040-2023 OI cozzolongo, raffaele/0000-0002-8343-5864; Osella, Alberto/0000-0003-4232-8760; Notarnicola, Maria/0000-0003-2274-2198; Sorino, Paolo/0000-0002-9081-2648; Campanella, Angelo/0000-0002-5044-4625; Aballay, Laura Rosana/0000-0002-3430-3566; , Irene/0000-0001-7051-1058; Buongiorno, Claudia/0000-0003-2689-1086; Bonfiglio, Caterina/0000-0002-8650-348X; FRANCO, ISABELLA/0000-0002-3697-0127 FU RC 2012-2014 [110/2014]; Apulia Region [1159] FX This work was supported by RC 2012-2014, Linea 4, C 32 (D.D.n.110/2014) and by Apulia Region D.G.R. n. 1159, 28 June 2018 and 2019. 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Gioxari, Aristea Kalafati, Ioanna Panagiota Diolintzi, Anastasia Kokkinos, Alexandros Dedoussis, George V. TI The Effectiveness of Mediterranean Diet in Nonalcoholic Fatty Liver Disease Clinical Course: An Intervention Study SO JOURNAL OF MEDICINAL FOOD LA English DT Article DE inflammation; Mediterranean diet; NAFLD; STAT3; steatosis; visfatin ID C-REACTIVE PROTEIN; OXIDATIVE STRESS; GENETIC-VARIANTS; STAT3; ASSOCIATION; OBESITY; SENSITIVITY; NAFLD; STEATOHEPATITIS; SUSCEPTIBILITY AB Diet is a modifiable key factor targeted in prevention and management of nonalcoholic fatty liver disease (NAFLD). The aim was to study the effect of Mediterranean Diet (MedDiet) on clinical, biochemical, and inflammatory profile in NAFLD patients with simple steatosis. Potential associations of signal transducer and activator of transcription 3 (STAT3) rs2293152 genotype to diet composition and patients' profile were investigated. In this nonrandomized, open-label, 24-week prospective intervention study, 44 untreated NAFLD patients with nonsignificant fibrosis received nutritional counsel to increase adherence to MedDiet. Adherence to MedDiet was estimated with MedDietScore. Furthermore, we genotyped STAT3 rs2293152 single nucleotide polymorphism and performed clinical and inflammatory measurements. In all patients, MedDietScore increased and anthropometric indices improved, whereas liver imaging, liver fibrosis score, blood pressure, fasting glucose, glycated hemoglobin (HbA1c), C-reactive protein (CRP), visfatin, and oxidized low-density lipoprotein levels were also significantly ameliorated compared with baseline (P < .05). No association of STAT3 polymorphism with diet composition was found. Comparisons of mean differences between G- and C-carriers at the end point of the trial showed that only visfatin was significantly associated with the STAT3 genotype (-0.0 +/- 4.6 vs. -4.2 +/- 3.9, P = .04, respectively). Carrying the G-allele was associated with an increase of the visfatin levels (3.4 +/- 1.5 ng/mL, P = .028). Our results show amelioration of clinical, biochemical, and inflammatory biomarkers in NAFLD patients in response to MedDiet. STAT3 rs2293152 G-carriers experienced more beneficial changes at the end of the intervention compared with baseline. An association between visfatin levels and STAT3 genotype has been shown for the first time. C1 [Kaliora, Andriana C.; Kalafati, Ioanna Panagiota; Diolintzi, Anastasia; Dedoussis, George V.] Harokopio Univ, Sch Hlth Sci & Educ, Dept Nutr & Dietet, 70 El Venizelou Ave, Athens 17671, Greece. [Gioxari, Aristea; Kokkinos, Alexandros] Univ Athens, Med Sch, Laiko Gen Hosp, Dept Propaedeut & Internal Med 1, Athens, Greece. C3 Harokopio University Athens; National & Kapodistrian University of Athens; Laiko General Hospital RP Dedoussis, GV (通讯作者)，Harokopio Univ, Sch Hlth Sci & Educ, Dept Nutr & Dietet, 70 El Venizelou Ave, Athens 17671, Greece. 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Med. Food PD JUL 1 PY 2019 VL 22 IS 7 BP 729 EP 740 DI 10.1089/jmf.2018.0020 PG 12 WC Chemistry, Medicinal; Food Science & Technology; Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Pharmacology & Pharmacy; Food Science & Technology; Nutrition & Dietetics GA II0UN UT WOS:000474920800011 PM 31290733 DA 2026-02-02 ER PT J AU Trovato, FM Martines, GF Brischetto, D Catalano, D Musumeci, G Trovato, GM AF Trovato, Francesca M. Martines, Giuseppe Fabio Brischetto, Daniela Catalano, Daniela Musumeci, Giuseppe Trovato, Guglielmo M. TI Fatty liver disease and lifestyle in youngsters: diet, food intake frequency, exercise, sleep shortage and fashion SO LIVER INTERNATIONAL LA English DT Article DE adolescents; fashion; fatty liver; lifestyle; NAFLD; obesity; youngsters ID MEDITERRANEAN DIET; PHYSICAL-ACTIVITY; NONALCOHOLIC STEATOHEPATITIS; ALANINE AMINOTRANSFERASE; INSULIN-RESISTANCE; NUTRITIONAL INTERVENTION; ESPRESSO DRINKING; REGULAR COFFEE; CLOTHING SIZE; BRIGHT LIVER AB Background & AimsFatty liver is associated with alcohol habits and/or overweight/obesity. We challenged several lifestyle features associated with fatty liver and, particularly, with non-alcoholic fatty liver disease (NAFLD). Among them, sleep shortage as a result of nightlife habits and a preference for plus-size fashion were assessed. The latter consists of fashionable plus-sized clothing for actual individuals' size and reflects a frequent attitude of some social or age groups, conceivably indicating more global and widespread trend and behaviour. MethodsWe studied a group of 708 non-diabetic youngsters, 458 women and 250 men, 21.72 3.71 years old (range 15-35 years), referred for minor digestive ailments for clinical assessment, ultrasound detection of fatty liver and nutritional counselling. Details of personal history regarding lifestyle, food intake frequency and alcohol intake, dietary and physical exercise profile, sleep duration and clothing preferences were recorded. ResultsThe prevalence of NAFLD in this cohort of youngsters is 67/708 (9.4%). Even if it is quantitatively very low in both groups, the average alcohol intake, always below 20 g/day, is greater in NAFLD subjects (5.83 +/- 4.32 g) vs. subjects with normal liver (2.02 +/- 3.20 g). The number of meals/day and adherence to a Mediterranean diet profile are smaller in NAFLD subjects. By multiple regression, BMI, sedentary life, plus-sized clothing for their actual size, sleep shortage and lower frequency of daily food intake are associated with the presence of NAFLD. ConclusionsOnset and continuation of fatty liver disease, beyond food and exercise quantity and quality, with their effects on obesity, may also be associated with other aspects of lifestyle. C1 [Trovato, Francesca M.; Martines, Giuseppe Fabio; Brischetto, Daniela; Catalano, Daniela; Trovato, Guglielmo M.] Univ Hosp Catania, Dept Clin & Expt Med, Catania, Italy. [Musumeci, Giuseppe] Univ Catania, Sch Med, Dept Biomed Sci, Human Anat & Histol Sect, Catania, Italy. C3 University of Catania; University Catania Hospital; University of Catania RP Trovato, GM (通讯作者)，Univ Catania, Sch Med, Univ Hosp Catania, Dept Clin & Expt Med, Via Santa Sofia 78,Padigl 4, I-95100 Catania, Italy. EM guglielmotrovato@unict.it RI Catalano, Daniela/J-2883-2012; Musumeci, Giuseppe/K-9955-2016 OI Trovato, Francesca Maria/0000-0002-8048-1646; Musumeci, Giuseppe/0000-0002-8260-8890; Trovato, Guglielmo M/0000-0002-1168-1919 CR Angulo P, 1999, HEPATOLOGY, V30, P1356, DOI 10.1002/hep.510300604 Anty R, 2012, J HEPATOL, V57, P1090, DOI 10.1016/j.jhep.2012.07.014 BAECKE JAH, 1982, AM J CLIN NUTR, V36, P936 Battram DS, 2011, APPL PHYSIOL NUTR ME, V36, P183, DOI [10.1139/H11-001, 10.1139/h11-001] Birerdinc A, 2012, ALIMENT PHARM THER, V35, P76, DOI 10.1111/j.1365-2036.2011.04916.x Bohte AE, 2011, EUR RADIOL, V21, P87, DOI 10.1007/s00330-010-1905-5 Catalano D, 2008, CLIMACTERIC, V11, P373, DOI 10.1080/13697130802348728 Catalano D, 2008, LIVER INT, V28, P1280, DOI 10.1111/j.1478-3231.2008.01742.x Catalano D, 2013, INT J CARDIOL, V168, P4408, DOI 10.1016/j.ijcard.2013.05.034 Catalano D, 2011, HEPATOL INT, V5, P822, DOI 10.1007/s12072-011-9254-2 Catalano D, 2010, DIGEST DIS SCI, V55, P3200, DOI 10.1007/s10620-010-1143-3 Cobbold JFL, 2012, J GASTROEN HEPATOL, V27, P1281, DOI 10.1111/j.1440-1746.2012.07127.x Cobbold JFL, 2012, HEPATOL RES, V42, P515, DOI 10.1111/j.1872-034X.2011.00948.x Dhurandhar NV, 2013, OBES REV, V14, P721, DOI 10.1111/obr.12045 Fraser A, 2007, GASTROENTEROLOGY, V133, P1814, DOI 10.1053/j.gastro.2007.08.077 Hattar LN, 2011, WORLD J GASTROENTERO, V17, P4396, DOI 10.3748/wjg.v17.i39.4396 Holmbäck I, 2010, BRIT J NUTR, V104, P1065, DOI 10.1017/S0007114510001753 Hsieh SD, 2011, INTERNAL MED, V50, P2499, DOI 10.2169/internalmedicine.50.5844 Ishibashi E, 2008, J GASTROEN HEPATOL, V23, P908, DOI 10.1111/j.1440-1746.2008.05366.x Kantartzis K, 2009, GUT, V58, P1281, DOI 10.1136/gut.2008.151977 Lazo M, 2011, BMJ-BRIT MED J, V343, DOI 10.1136/bmj.d6891 Liangpunsakul S, 2005, AM J MED SCI, V329, P111, DOI 10.1097/00000441-200503000-00001 Loomba R, 2015, J HEPATOL, V63, P10, DOI 10.1016/j.jhep.2015.03.009 Machado MV, 2013, J HEPATOL, V58, P1007, DOI 10.1016/j.jhep.2012.11.021 Machado MV, 2011, LIVER INT, V31, P280, DOI 10.1111/j.1478-3231.2010.02445.x Méndez-Sánchez N, 2007, LIVER INT, V27, P423, DOI 10.1111/j.1478-3231.2007.01483.x Mir HM, 2013, J CLIN EXP HEPATOL, V3, P181, DOI 10.1016/j.jceh.2013.06.004 Nafiu OO, 2013, ISRN OBES, V11, P2013 Oh S, 2015, HEPATOLOGY, V61, P1205, DOI 10.1002/hep.27544 Petroff AB, 2011, BODY IMAGE, V8, P126, DOI 10.1016/j.bodyim.2011.02.003 Shima T, 2015, HEPATOL RES, V45, P548, DOI 10.1111/hepr.12384 Sorbi D, 1999, AM J GASTROENTEROL, V94, P1018 Spiegel K, 2004, ANN INTERN MED, V141, P846, DOI 10.7326/0003-4819-141-11-200412070-00008 Stewart KE, 2015, LIVER INT, V35, P936, DOI 10.1111/liv.12483 Thakkar MM, 2015, ALCOHOL, V49, P299, DOI 10.1016/j.alcohol.2014.07.019 Treasure JL, 2008, BRIT J PSYCHIAT, V192, P243, DOI 10.1192/bjp.bp.107.044164 Trichopoulou A, 2003, NEW ENGL J MED, V348, P2599, DOI 10.1056/NEJMoa025039 Trovato FM, 2015, CLIN NUTR, V34, P86, DOI 10.1016/j.clnu.2014.01.018 Trovato GM, 2012, CLIN TER, V163, P281 Trovato GM, 2012, CLIN TER, V163, P299 Trovato G, 2014, CHRONOBIOL INT, V31, P945, DOI 10.3109/07420528.2014.931414 Trovato G, 2014, HEADACHE, V54, P1062, DOI 10.1111/head.12374 Trovato G, 2014, OBESITY, V22, P1209, DOI 10.1002/oby.20712 Trovato GM, 2014, ANN NEUROL, V75, P613, DOI 10.1002/ana.23991 Trovato GM, 2013, AM J GASTROENTEROL, V108, P1932, DOI 10.1038/ajg.2013.356 Trovato GM, 2013, AM J EPIDEMIOL, V178, P661, DOI 10.1093/aje/kwt125 Trovato GM, 2013, J HEPATOL, V58, P1264, DOI 10.1016/j.jhep.2013.01.033 Trovato GM, 2012, EPMA J, V3, DOI 10.1007/s13167-012-0141-2 Trovato GM, 2012, J CLIN GASTROENTEROL, V46, pE46, DOI 10.1097/MCG.0b013e31824b225c Trovato GM, 2012, DIGEST DIS SCI, V57, P535, DOI 10.1007/s10620-011-1903-8 Trovato GM, 2010, LIVER INT, V30, P184, DOI 10.1111/j.1478-3231.2009.02127.x Volynets V, 2013, EUR J NUTR, V52, P527, DOI 10.1007/s00394-012-0355-z Wills W, 2006, SOC SCI MED, V62, P396, DOI 10.1016/j.socscimed.2005.06.014 Wong VWS, 2013, J HEPATOL, V59, P536, DOI 10.1016/j.jhep.2013.04.013 Yan YX, 2009, J EPIDEMIOL, V19, P333, DOI 10.2188/jea.JE20080086 Younossi ZM, 2012, MEDICINE, V91, P319, DOI 10.1097/MD.0b013e3182779d49 NR 56 TC 71 Z9 143 U1 0 U2 31 PU WILEY-BLACKWELL PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1478-3223 EI 1478-3231 J9 LIVER INT JI Liver Int. PD MAR PY 2016 VL 36 IS 3 BP 427 EP 433 DI 10.1111/liv.12957 PG 7 WC Gastroenterology & Hepatology WE Science Citation Index Expanded (SCI-EXPANDED) SC Gastroenterology & Hepatology GA DE2HR UT WOS:000370448700015 PM 26346413 DA 2026-02-02 ER PT J AU Bullón-Vela, V Abete, I Zulet, MA Tur, JA Pintó, X Corbella, E Martínez-González, MA Corella, D Macías-González, M Tinahones, F Fitó, M Estruch, R Ros, E Salas-Salvadó, J Daimiel, L Martínez, JA AF Bullon-Vela, Vanessa Abete, Itziar Angeles Zulet, M. Tur, Josep A. Pinto, Xavier Corbella, Emili Martinez-Gonzalez, Miguel A. Corella, Dolores Macias-Gonzalez, Manuel Tinahones, Francisco Fito, Montserrat Estruch, Ramon Ros, Emilio Salas-Salvado, Jordi Daimiel, Lidia Alfredo Martinez, J. TI Risk factors differentially associated with non-alcoholic fatty liver disease in males and females with metabolic syndrome SO REVISTA ESPANOLA DE ENFERMEDADES DIGESTIVAS LA English DT Article DE Non-alcoholic fatty liver disease; Abdominal obesity; Metabolic syndrome; Visceral adipose tissue; Sex ID MEDITERRANEAN DIET; NAFLD; PROGRESSION; ADHERENCE; SURVIVAL; GENDER; INDEX AB Background and aims: non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in western countries.This study aimed to investigate putative risk factors differentially related with NAFLD in obese males and females diagnosed with metabolic syndrome (MetS), stratified using the non-invasive hepatic steatosis index (HSI). Methods: a cross-sectional analysis of the PREDIMED Plus study was performed of 278 participants with MetS (141 males and 137 females) of the Navarra-Nutrition node. Subjects were categorized by HSI tertiles and gender. Baseline clinical, biochemical variants and adherence to a Mediterranean diet and physical activity were evaluated. Results: multivariate analyses showed that females had 4.54 more units of HSI (95% CI: 3.41 to 5.68) than males. Both sexes showed increased levels of triglycerides,TG/HDL cholesterol ratio and triglyceride glucose index across the HSI tertiles. Physical activity exhibited a negative statistical association with HSI (males: r = -0.19, p = 0.025; females: r = -0.18, p = 0.031). The amount of visceral fat showed a positive association with HSI in both sexes (males: r = 0.64, p < 0.001; females: r = 0.46, p < 0.001). Adherence to the Mediterranean diet was lower in those subjects with higher HSI values (males: r = -0.18, p = 0.032; females r= -0.19, p = 0.027). Conclusion: females had a poor liver status, suggesting gender differences related to NAFLD. Adherence to a Mediterranean diet and physical activity were associated with beneficial effects on cardiovascular disease features.Thus, reducing the risk of hepatic steatosis in subjects with MetS and obesity. C1 [Bullon-Vela, Vanessa; Abete, Itziar; Angeles Zulet, M.; Alfredo Martinez, J.] Univ Navarra, Dept Nutr Food Sci & Physiol, Ctr Nutr Res, C Irunlarrea 1, Pamplona 31008, Spain. [Abete, Itziar; Angeles Zulet, M.; Tur, Josep A.; Pinto, Xavier; Corbella, Emili; Martinez-Gonzalez, Miguel A.; Corella, Dolores; Macias-Gonzalez, Manuel; Tinahones, Francisco; Fito, Montserrat; Estruch, Ramon; Ros, Emilio; Salas-Salvado, Jordi; Alfredo Martinez, J.] Inst Salud Carlos III, CIBER Physiopathol Obes & Nutr CIBERobn, Madrid, Spain. [Angeles Zulet, M.; Alfredo Martinez, J.] Inst Invest Sanitaria Navarra IdiSNA, Pamplona, Spain. [Tur, Josep A.] Univ Balearic Isl, Res Grp Community Nutr & Oxidat Stress, Palma De Mallorca, Spain. [Pinto, Xavier; Corbella, Emili] Hosp Univ Bellvitge, Lipids & Vasc Risk Unit, Internal Med Serv, Barcelona, Spain. [Martinez-Gonzalez, Miguel A.] Univ Navarra, Dept Prevent Med & Publ Hlth, Pamplona, Spain. [Corella, Dolores] Univ Valencia, Dept Prevent Med, Valencia, Spain. [Macias-Gonzalez, Manuel; Tinahones, Francisco] Univ Malaga, Dept Endocrinol, Hosp Univ Virgen Victoria, Malaga, Spain. [Fito, Montserrat] Inst Hosp Mar Invest Med IMIM, Cardiovasc Risk & Nutr Res Grp CARIN, Barcelona, Spain. [Estruch, Ramon] Univ Barcelona, Dept Internal Med, IDIBAPS, Hosp Clin, Barcelona, Spain. [Ros, Emilio] Hosp Cl Nic, Lipid Clin Dept Endocrinol & Nutr, Inst Invest Biomed August Pi Sunyer IDIBAPS, Barcelona, Spain. [Salas-Salvado, Jordi] Univ Rovira & Virgili, Human Nutr Unit, Hosp Univ St Joan de Reus, Dept Biochem & Biotechnol,Inst Invest Sanitaria, Tarragona, Spain. [Daimiel, Lidia; Alfredo Martinez, J.] Inst Madrid Estudios Avanzados IMDEA Food, Madrid, Spain. C3 University of Navarra; CIBER - Centro de Investigacion Biomedica en Red; CIBEROBN; Instituto de Salud Carlos III; Universitat de les Illes Balears; University of Barcelona; Institut d'Investigacio Biomedica de Bellvitge (IDIBELL); Bellvitge University Hospital; University of Navarra; University of Valencia; Universidad de Malaga; Hospital Virgen de la Victoria; Hospital del Mar Research Institute; University of Barcelona; Hospital Clinic de Barcelona; IDIBAPS; University of Barcelona; Hospital Clinic de Barcelona; IDIBAPS; Universitat Rovira i Virgili; IMDEA Food Institute RP Zulet, MA (通讯作者)，Univ Navarra, Dept Nutr Food Sci & Physiol, Ctr Nutr Res, C Irunlarrea 1, Pamplona 31008, Spain. EM mazulet@unav.es RI Corbella, Emili/AGI-4105-2022; Daimiel-Ruiz, Lidia Ángeles/M-7779-2014; Tinahones, Francisco J/AAB-2882-2020; Pintó Sala, Xavier/AGI-4297-2022; Salas-Salvadó, Jordi/C-7229-2017; Bullón-Vela, Vanessa/AFR-2561-2022; Tur, Josep/AAE-5748-2020; Fito, Montserrat/C-1822-2012; Macias-Gonzalez, Manuel/E-7584-2016; Martinez-Gonzalez, Miguel/AAE-7669-2019; Martínez, J./K-8709-2014; Estruch, Ramon/AAZ-3723-2020; Corella, Dolores/L-9888-2014 OI Corbella, Emili/0000-0001-8818-1907; Daimiel-Ruiz, Lidia Ángeles/0000-0001-9898-6629; Tinahones, Francisco J/0000-0001-6871-4403; Pintó Sala, Xavier/0000-0002-2216-2444; Salas-Salvadó, Jordi/0000-0003-2700-7459; Bullón-Vela, Vanessa/0000-0003-3639-821X; FU Department of Health of the Government of Navarra [61/2015]; Fundacio La Marato de TV [201630.10]; Carlos III Health Institute (ISCIII), through the Funding Agency for Health Research (FIS) [PI14/01919, PI17/00926]; European Regional Development Fund (ERDF); CIBER Fisiopatologia de la Obesidad y Nutricion (CIBERobn); European Research Council [340918]; Centre for Nutrition Research-University of Navarra; European Research Council (ERC) [340918] Funding Source: European Research Council (ERC) FX The authors express their gratitude for the financial support received from the Department of Health of the Government of Navarra (61/2015), the Fundacio La Marato de TV (Ref. 201630.10), the Carlos III Health Institute (ISCIII), through the Funding Agency for Health Research (FIS, PI14/01919 and PI17/00926), co-funded by the European Regional Development Fund (ERDF), CIBER Fisiopatologia de la Obesidad y Nutricion (CIBERobn) and the European Research Council (Advanced Research Grant 2014-2019; agreement #340918 granted to MAM-G). VBV received a grant from the Centre for Nutrition Research-University of Navarra. 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PY 2020 VL 112 IS 2 BP 94 EP 100 DI 10.17235/reed.2019.6031/2018 PG 7 WC Gastroenterology & Hepatology WE Science Citation Index Expanded (SCI-EXPANDED) SC Gastroenterology & Hepatology GA KK8JY UT WOS:000512983800004 PM 31880161 OA Green Submitted DA 2026-02-02 ER PT J AU Gabbia, D AF Gabbia, Daniela TI Beneficial Effects of Tyrosol and Oleocanthal from Extra Virgin Olive Oil on Liver Health: Insights into Their Mechanisms of Action SO BIOLOGY-BASEL LA English DT Review DE tyrosol; oleocanthal; extra virgin olive oil; chronic liver disease; fibrosis; hepatocellular carcinoma; metabolic dysfunction-associated steatotic liver disease; metabolic dysfunction-associated steatohepatitis ID MEDITERRANEAN DIET; METABOLIC SYNDROME; PHENOLIC-COMPOUNDS; LIPID-METABOLISM; ANTIOXIDANT; HYDROXYTYROSOL; DISEASE; CANCER; IMPACT; MODULATION AB Simple Summary Consumption of extra virgin olive oil (EVOO) is associated with many beneficial effects on human health as a result of its phenolic-derived compounds. This review explores the hepatoprotective properties and mechanisms of action of tyrosol and oleocanthal from extra virgin olive oil. Both compounds demonstrate antioxidant, anti-inflammatory, and modulatory effects on liver metabolism that improve chronic liver diseases, such as dysfunction-associated steatotic liver disease (MASLD) and liver fibrosis, and their progression to liver cancer. Mechanistic studies have suggested that these compounds exert their hepatoprotective effects through the regulation of multiple cellular pathways, including those involved in the antioxidant response and lipid metabolism. Understanding these mechanisms may provide valuable information for the development of therapeutic agents based on their chemical structures that are useful to improve liver health and prevent liver-related disorders.Abstract The Mediterranean diet and consumption of EVOO are associated with multiple beneficial effects for human health, e.g. reduction in cardiovascular risk and mortality, improvement in the lipid profile, and the prevention of chronic diseases, such as cancers and neurodegenerative diseases. In EVOO, more than 30 different phenolic-derived compounds have been identified, representing one of the most promising bioactive classes in olive oil. This review explores the hepatoprotective properties of two of these compounds, tyrosol and oleocanthal, focusing on their mechanisms of action. Recent studies have shown that these compounds, which share a similar chemical structure with a hydroxyl group attached to an aromatic hydrocarbon ring, can potentially mitigate chronic liver diseases, such as MASLD and liver fibrosis, as well as their progression to liver cancer. Consequently, they deserve attention for future pharmacological drug development. In vitro and in vivo studies have suggested that these compounds exert these effects through the regulation of cellular pathways involved in antioxidant response, lipid metabolism, transcription factor activity, and NF-kappa B signaling. Understanding the mechanisms underlying the hepatoprotective properties of tyrosol and oleocanthal may provide valuable information for the development of therapeutic agents based on their chemical structures capable of targeting chronic liver diseases. C1 [Gabbia, Daniela] Univ Padua, Dept Pharmaceut & Pharmacol Sci, I-35131 Padua, Italy. C3 University of Padua RP Gabbia, D (通讯作者)，Univ Padua, Dept Pharmaceut & Pharmacol Sci, I-35131 Padua, Italy. 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Nardone, Gerardo Ranieri, Luisa Napolitano, Luigi Crocetto, Felice Barone, Biagio Arcaniolo, Davide Spirito, Lorenzo Manfredi, Celeste Gravina, Antonietta Gerarda Sciorio, Carmine Tufano, Antonio Cioffi, Antonio Fusco, Ferdinando Romano, Marco De Sio, Marco TI Sexual dysfunctions in patients with well-compensated chronic liver disease: role of etiology, Mediterranean diet and quality of life in an observational cross-sectional study SO SEXUAL MEDICINE LA English DT Article DE sexual dysfunctions; Mediterranean diet; quality of life; chronic liver disease; MASLD-FSFI; Iief ID 4TH INTERNATIONAL CONSULTATION; CHRONIC HEPATITIS-C; ERECTILE DYSFUNCTION; ENDOTHELIAL DYSFUNCTION; CONSENSUS STATEMENT; EGYPTIAN PATIENTS; WOMEN; MEN; PREVALENCE; INDEX AB Background Sexual dysfunctions (SD) are highly prevalent in Chronic Liver Diseases (CLD). Whether Metabolic dysfunction-Associated Steatotic Liver Disease (MASLD) carries a higher risk of SD is unknown as is the role of dietary patterns or quality of Life (QoL). Aim to assess (1) prevalence of SD in CLD; (2) whether MASLD is a risk factor for SD; (3) the role of adherence to Mediterranean Diet (MD) or QoL. Methods Observational, cross-sectional study, 207 CLD patients (84 females and 123 males), median age 57 years (IQR:46-63); 96 (46.4%) MASLD; and 111 (53.6%) nonMASLD. Outcomes SD were assessed through Female Sexual Function Index (FSFI) and International Index of Erectile Function (IIEF) questionnaires. Adherence to MD was evaluated by the MD Score, QoL by SFHS-12 questionnaire evaluating physical [(ie, Physical Component Summary (PCS)] and mental [(ie, Mental Component Summary (MCS)] health. Multivariate analysis identified predictors of SD. Results (1) SD prevalence in CLD was 157/207 (75.8%); 80.9% females were at risk for SD, altered sexual desire/arousal and dyspareunia being the most common complaints, whereas 72.3% males had erectile dysfunction (ED); (2) prevalence of SD was higher in MASLD (89%) than in nonMASLD (64%) (P < 0.001); (3) in females, at univariate analysis, a negative correlation was found between FSFI and age, hypertension, or MASLD; (4) in males, at univariate analysis, IIEF-ED negatively correlated with age, DM2, or MASLD, whereas positively correlated with PCS and MCS; (5) in females, at multivariate analysis BMI (OR = 0.779,CI 95% = 0.640-0.948) and MCS (OR = 0.840,CI 95% = 0.741-0.953) were protective against SD, whereas age (OR = 1.115,CI 95% = 1.040-1.263) and DM2 (OR = 120.894,CI 95% = 1.396-10 741) were predictive of SD; (6) in males, at multivariate analysis, age (OR = 1088,CI 95% = 1032-1.148) and MASLD (OR = 4.075,CI 95% = 1.120-14.828) were risk factors for, whereas PCS (OR = 0,928,CI 95% = 0,865-0,995), and disease duration (OR = 0.393,CI 95% = 0.187-0.822) were protective against SD; 7) MD adherence, while higher in nonMASLD vs MASLD (P = 0.004), was not an independent protective factor against SD. Clinical Implications SD should not be underestimated in CLD patients, in particular those with MASLD. Strengths and Limitations Comprehensive study evaluating SD in a large cohort of CLD patients of both sexes, comparing MASLD vs nonMASLD. Due to its cross-sectional design, no conclusions can be drawn about cause and effect. Conclusions (1) CLD, in particular MASLD, have a high prevalence of SD which is not affected by MD adherence, whereas QoL seems to play a role; (2) CLD patients should be evaluated for SD, for early diagnosis and treatment. C1 [Romano, Lorenzo; Arcaniolo, Davide; Spirito, Lorenzo; Manfredi, Celeste; De Sio, Marco] Univ Campania Luigi Vanvitelli, Dept Woman Child & Gen & Specialized Surg, I-80138 Naples, Italy. [Romano, Lorenzo; Arcaniolo, Davide; Spirito, Lorenzo; De Sio, Marco] Univ Campania Luigi Vanvitelli, Urol Unit, I-80138 Naples, Italy. [Romano, Lorenzo; Cioffi, Antonio] Osped Mare, Urol Unit, I-80147 Naples, Italy. [Fonticelli, Mariano; Priadko, Kateryna; Gravina, Antonietta Gerarda; Romano, Marco] Univ Campania Luigi Vanvitelli, Dept Precis Med, I-80138 Naples, Italy. [Fonticelli, Mariano; Priadko, Kateryna; Gravina, Antonietta Gerarda; Romano, Marco] Univ Campania Luigi Vanvitelli, Hepatogastroenterol Unit, I-80138 Naples, Italy. [Morisco, Filomena; Rocco, Alba; Nardone, Gerardo; Ranieri, Luisa] Univ Naples Federico II, Dept Clin Med & Surg, Gastroenterol Unit, I-80131 Naples, Italy. [Napolitano, Luigi; Crocetto, Felice; Barone, Biagio] Univ Naples Federico II, Dept Neurosci Reprod Sci & Odontostomatol, I-80131 Naples, Italy. [Napolitano, Luigi; Crocetto, Felice; Barone, Biagio] Univ Naples Federico II, Urol Unit, I-80131 Naples, Italy. [Sciorio, Carmine] Alessandro Manzoni Gen Hosp, Urol Unit, I-23900 Lecce, Italy. [Cioffi, Antonio] IRCCS Fdn G Pascale, Ist Nazl Tumori, Urol Unit, I-80131 Naples, Italy. [Fusco, Ferdinando] AO St Anna & San Sebastiano, Urol Unit, I-81100 Caserta, Italy. C3 Universita della Campania Vanvitelli; Universita della Campania Vanvitelli; Universita della Campania Vanvitelli; Universita della Campania Vanvitelli; University of Naples Federico II; University of Naples Federico II; University of Naples Federico II; IRCCS Fondazione Pascale; Fondazione IRCCS Istituto Nazionale Tumori Milan RP Romano, L (通讯作者)，Univ Campania L Vanvitelli, Dept Woman Child & Gen & Specialized Surg, Piazza L Miraglia 2, I-80138 Naples, Italy. EM lorenzo.romano@unicampania.it RI Priadko, Kateryna/NUQ-2161-2025; Gravina, Antonietta Gerarda/AAC-1528-2019; Cioffi, Antonio/AAM-9160-2020; Napolitano, Luigi/GLU-7753-2022; Tufano, Antonella/AHD-0570-2022; Barone, Biagio/AAY-2704-2020; De Sio, Marco/AAA-6330-2021; ROCCO, ALBA/L-3974-2016; Manfredi, Celeste/W-4320-2019 OI Romano, Lorenzo/0000-0002-6581-7930 CR Bajos N, 2010, BRIT MED J, V340, DOI 10.1136/bmj.c2573 Bauer SR, 2020, JAMA NETW OPEN, V3, DOI 10.1001/jamanetworkopen.2020.21701 Bivalacqua TJ, 2003, J ANDROL, V24, pS17 BURNETT AL, 1992, SCIENCE, V257, P401, DOI 10.1126/science.1378650 Caussy C, 2021, CURR DIABETES REP, V21, DOI 10.1007/s11892-021-01383-7 Chiang HC, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0206438 Chien YC, 2015, BMC UROL, V15, DOI 10.1186/s12894-015-0078-6 Child C G, 1964, Major Probl Clin Surg, V1, P1 Corona G, 2023, J ENDOCRINOL INVEST, V46, P1241, DOI 10.1007/s40618-023-02015-5 Crocetto F., 2022, PILOT STUDY J PHYSL, V73, P15, DOI [10.26402/jpp.2022.1.05, DOI 10.26402/JPP.2022.1.05] Dayi Taygun, 2022, J Prev Med Hyg, V63, pE56, DOI 10.15167/2421-4248/jpmh2022.63.2S3.2747 Di Stasi V, 2021, FRONT ENDOCRINOL, V12, DOI 10.3389/fendo.2021.641446 Dilixiati D, 2024, EUR J PREV CARDIOL, V31, P782, DOI 10.1093/eurjpc/zwae042 Duman DG, 2016, J SEX MED, V13, P383, DOI 10.1016/j.jsxm.2015.12.030 Elshimi E, 2019, J SEX MED, V16, P402, DOI 10.1016/j.jsxm.2019.01.309 Elshimi E, 2014, J SEX MED, V11, P768, DOI 10.1111/jsm.12412 Eren H, 2019, BJU INT, V124, P329, DOI 10.1111/bju.14753 Esposito K, 2007, INT J IMPOT RES, V19, P353, DOI 10.1038/sj.ijir.3901548 Faubion SS, 2020, J SEX MED, V17, P1971, DOI 10.1016/j.jsxm.2020.07.004 Federico A, 2020, INT J ENV RES PUB HE, V17, DOI 10.3390/ijerph17103369 Foucher J, 2006, GUT, V55, P403, DOI 10.1136/gut.2005.069153 Hawksworth DJ, 2020, SEX MED REV, V8, P274, DOI 10.1016/j.sxmr.2019.01.002 Jannini EA, 2017, SEX MED REV, V5, P298, DOI 10.1016/j.sxmr.2017.04.002 Kadioglu P, 2010, BJU INT, V106, P1357, DOI 10.1111/j.1464-410X.2010.09348.x Kani HT, 2021, HEPATOL FORUM, V2, P60, DOI 10.14744/hf.2021.2021.0012 Karaivazoglou K, 2017, EUR J GASTROEN HEPAT, V29, P1197, DOI 10.1097/MEG.0000000000000949 Kim JA, 2006, CIRCULATION, V113, P1888, DOI 10.1161/CIRCULATIONAHA.105.563213 Laumann EO, 2005, INT J IMPOT RES, V17, P39, DOI 10.1038/sj.ijir.3901250 Lee JY, 2017, PLOS ONE, V12, DOI 10.1371/journal.pone.0182708 Li D, 2010, HUM REPROD, V25, P519, DOI 10.1093/humrep/dep381 Liao XM, 2022, J SEX MED, V19, P207, DOI 10.1016/j.jsxm.2021.11.016 Lin YC, 2025, INT J IMPOT RES, V37, P320, DOI 10.1038/s41443-024-00914-6 Lindau ST, 2007, NEW ENGL J MED, V357, P762, DOI 10.1056/NEJMoa067423 Lou IX, 2023, VASC HEALTH RISK MAN, V19, P691, DOI 10.2147/VHRM.S439334 Maiorino MI, 2018, J ENDOCRINOL INVEST, V41, P1249, DOI 10.1007/s40618-018-0872-6 Maiorino MI, 2016, DIABETES CARE, V39, pE143, DOI 10.2337/dc16-0910 McCabe M, 2015, J SEX MED, V12, P301, DOI 10.1016/j.jsxm.2015.12.019 McCabe MP, 2016, J SEX MED, V13, P144, DOI 10.1016/j.jsxm.2015.12.034 Mollaioli D, 2020, REPROD BIOL ENDOCRIN, V18, DOI 10.1186/s12958-019-0557-9 Mozafari M, 2015, IRAN RED CRESCENT ME, V17, DOI 10.5812/ircmj.24685 Neong SF, 2019, HEPATOLOGY, V69, P2683, DOI 10.1002/hep.30359 Noureddin M, 2024, CLIN GASTROENTEROL H, V22, P9, DOI 10.1016/j.cgh.2023.09.034 Pasarín M, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0032785 Paternostro R, 2018, LIVER INT, V38, P1427, DOI 10.1111/liv.13704 Persico M, 2017, BMC GASTROENTEROL, V17, DOI 10.1186/s12876-017-0592-y Philonenko S, 2019, DIGEST LIVER DIS, V51, P850, DOI 10.1016/j.dld.2019.03.030 PUGH RNH, 1973, BRIT J SURG, V60, P646, DOI 10.1002/bjs.1800600817 Romano L, 2025, ANDROLOGY-US, V13, P1693, DOI 10.1111/andr.13791 Romano L, 2022, SEX MED REV, V10, P620, DOI 10.1016/j.sxmr.2021.02.002 Romano L, 2022, ANDROLOGY-US, V10, P910, DOI 10.1111/andr.13186 Rosen RC, 1997, UROLOGY, V49, P822, DOI 10.1016/S0090-4295(97)00238-0 Smith L, 2019, PLOS ONE, V14, DOI 10.1371/journal.pone.0221979 Sorrell JH, 2006, LIVER TRANSPLANT, V12, P1473, DOI 10.1002/lt.20812 Towe M, 2020, SEX MED REV, V8, P256, DOI 10.1016/j.sxmr.2019.08.004 Trichopoulou A, 2003, NEW ENGL J MED, V348, P2599, DOI 10.1056/NEJMoa025039 Ware JE, 1996, MED CARE, V34, P220, DOI 10.1097/00005650-199603000-00003 Wiegel M, 2005, J SEX MARITAL THER, V31, P1, DOI 10.1080/00926230590475206 Zang GH, 2023, FRONT PUBLIC HEALTH, V10, DOI 10.3389/fpubh.2022.1092353 NR 58 TC 0 Z9 0 U1 0 U2 1 PU OXFORD UNIV PRESS PI OXFORD PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND EI 2050-1161 J9 SEX MED-UK JI Sex. Med. PD APR PY 2025 VL 13 IS 2 AR qfaf025 DI 10.1093/sexmed/qfaf025 PG 11 WC Medicine, General & Internal; Urology & Nephrology WE Science Citation Index Expanded (SCI-EXPANDED) SC General & Internal Medicine; Urology & Nephrology GA 1TQ0T UT WOS:001473370400001 PM 40276567 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Quetglas-Llabrés, MM Monserrat-Mesquida, M Bouzas, C Llompart, I Mateos, D Casares, M Ugarriza, L Martínez, JA Tur, JA Sureda, A AF Quetglas-Llabres, Maria Magdalena Monserrat-Mesquida, Margalida Bouzas, Cristina Llompart, Isabel Mateos, David Casares, Miguel Ugarriza, Lucia Martinez, J. Alfredo Tur, Josep A. Sureda, Antoni TI Mediterranean Diet Improves Plasma Biomarkers Related to Oxidative Stress and Inflammatory Process in Patients with Non-Alcoholic Fatty Liver Disease SO ANTIOXIDANTS LA English DT Article DE non-alcoholic fatty liver disease; Mediterranean diet; metabolic syndrome; oxidative stress; inflammation ID INTESTINAL PERMEABILITY; INSULIN-RESISTANCE; ASSOCIATION; CYTOKERATIN-18; MICROBIOTA; REDUCTION; SEVERITY; STRATEGY; BENEFITS; OMENTIN AB Non-alcoholic fatty liver disease (NAFLD) shows liver fat depots without alcohol consumption. NAFLD does not have specific drug therapies, with a healthy lifestyle and weight loss being the main approaches to prevent and treat NAFLD. The aim was to assess the antioxidant and pro-inflammatory state in patients with NAFLD after 12-month-lifestyle intervention depending on the change in adherence to a Mediterranean diet (AMD). Antioxidant and inflammatory biomarkers were measured in 67 adults (aged 40-60 years old) diagnosed with NAFLD. Anthropometric parameters and dietary intake were measured by a validated semi-quantitative 143-item food frequency questionnaire. The nutritional intervention improved anthropometric and biochemical parameters after a 12-month follow-up. However, decreases in alanine aminotransferase (ALT) and C reactive protein (CRP) were higher in participants with high AMD, which also showed higher improvement in physical fitness (Chester step test) and intrahepatic fat contents. The intervention reduced plasma levels of malondialdehyde, myeloperoxidase, zonulin, and omentin, and increased resolvin D1 (RvD1), whereas the decrease in leptin, ectodysplasin-A (EDA), cytokeratin-18 (CK-18), interleukin-1ra (IL-1ra) and endotoxin was only significant in participants with higher AMD. The current study showed that a one-year nutritional intervention improved main NAFLD features such as body mass index, IFC, liver enzymes, and prooxidant and proinflammatory status. There was also a decrease in the concentration of plasmatic endotoxin, suggesting an improvement in intestinal permeability. These health benefits were more evident in participants that improved AMD to a greater extent. The trial was registered at ClinicalTrials.gov with registry number NCT04442620. C1 [Quetglas-Llabres, Maria Magdalena; Monserrat-Mesquida, Margalida; Bouzas, Cristina; Llompart, Isabel; Mateos, David; Ugarriza, Lucia; Tur, Josep A.; Sureda, Antoni] Univ Balearic Isl, Res Grp Community Nutr & Oxidat Stress, IUNICS, Palma De Mallorca 07122, Spain. [Quetglas-Llabres, Maria Magdalena; Monserrat-Mesquida, Margalida; Bouzas, Cristina; Llompart, Isabel; Mateos, David; Ugarriza, Lucia; Tur, Josep A.; Sureda, Antoni] Hlth Res Inst Balearic Isl IdISBa, Palma De Mallorca 07120, Spain. [Monserrat-Mesquida, Margalida; Bouzas, Cristina; Llompart, Isabel; Mateos, David; Martinez, J. Alfredo; Tur, Josep A.; Sureda, Antoni] Inst Salud Carlos III ISCIII, CIBER Fisiopatol Obes & Nutr CIBEROBN, Madrid 28029, Spain. [Casares, Miguel] Red Asistencial Juaneda, Radiodiag Serv, Palma De Mallorca 07011, Spain. [Ugarriza, Lucia] Univ Hosp Son Espases, Clin Anal Serv, Palma De Mallorca 07198, Spain. [Martinez, J. Alfredo] CEI UAM CSIC, Cardiometab Precis Nutr Program, IMDEA Food, Madrid 28049, Spain. [Martinez, J. Alfredo] Univ Navarra, Dept Nutr Food Sci & Physiol, Pamplona 31008, Spain. C3 Universitat de les Illes Balears; IUNICS; Institut Investigacio Sanitaria Illes Balears (IdISBa); CIBER - Centro de Investigacion Biomedica en Red; CIBEROBN; Hospital Universitari Son Espases; Consejo Superior de Investigaciones Cientificas (CSIC); IMDEA Food Institute; University of Navarra RP Tur, JA (通讯作者)，Univ Balearic Isl, Res Grp Community Nutr & Oxidat Stress, IUNICS, Palma De Mallorca 07122, Spain.; Tur, JA (通讯作者)，Hlth Res Inst Balearic Isl IdISBa, Palma De Mallorca 07120, Spain.; Tur, JA (通讯作者)，Inst Salud Carlos III ISCIII, CIBER Fisiopatol Obes & Nutr CIBEROBN, Madrid 28029, Spain. EM m.quetglas@uib.es; margalida.monserrat@uib.es; cristina.bouzas@uib.es; isabel.llompart@ssib.es; davidfrom13@gmail.com; casaresmiguel@gmail.com; luciaugarriza@gmail.com; jalfredo.martinez@imdea.org; pep.tur@uib.es; antoni.sureda@uib.es RI Bouzas, Cristina/AAE-2069-2019; Sureda, Antoni/N-9588-2019; Martínez, J./K-8709-2014; Tur, Josep/AAE-5748-2020; Monserrat Mesquida, Margalida/AAB-4773-2019; Quetglas Llabrés, Maria Magdalena/AAA-4412-2019 OI Tur, Josep/0000-0002-6940-0761; Bouzas Velasco, Cristina/0000-0002-1407-8461; Monserrat Mesquida, Margalida/0000-0002-8856-135X; Quetglas Llabrés, Maria Magdalena/0000-0003-4155-7780; , Antoni/0000-0001-8656-6838 FU Fundacio~La Marato~TV3 (Spain) [201630.10]; Instituto de Salud Carlos III [CIBEROBN CB12/03/30038, CIBER OBN18PI03]; Health Department of the Government of Navarra [61/2015]; (Balearic Islands Gov.) - European Regional Development Fund [35/2011, 23/2012]; IDISBA pre-doctoral grant [JUNIOR19-05]; SOIB Program for Qualified Young People; Juan de la Cierva post-doc grant FX Fundacio La Marato TV3 (Spain) project ref. 201630.10. Instituto de Salud Carlos III through the CIBEROBN CB12/03/30038, and Proyecto Intramural CIBER OBN18PI03), Health Department of the Government of Navarra (61/2015), and Grant of support to research groups no. 35/2011 and 23/2012 (Balearic Islands Gov.), which are co-funded by the European Regional Development Fund. M.M.Q.-L. was granted by the IDISBA pre-doctoral grant (JUNIOR19-05). M.M.-M. was granted by SOIB Program for Qualified Young People. C.B. was granted by a Juan de la Cierva post-doc grant. The funding sponsors had no role in the design of the study, in the collection, analyses, or interpretation of the data; in the writing of the manuscript, or in the decision to publish the results. 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Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND EI 2076-3921 J9 ANTIOXIDANTS-BASEL JI Antioxidants PD APR PY 2023 VL 12 IS 4 AR 833 DI 10.3390/antiox12040833 PG 17 WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science & Technology WE Science Citation Index Expanded (SCI-EXPANDED) SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science & Technology GA E9LN0 UT WOS:000978671400001 PM 37107208 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Castelnuovo, G Perez-Diaz-del-Campo, N Rosso, C Guariglia, M Armandi, A Nicolosi, A Caviglia, GP Bugianesi, E AF Castelnuovo, Gabriele Perez-Diaz-del-Campo, Nuria Rosso, Chiara Guariglia, Marta Armandi, Angelo Nicolosi, Aurora Caviglia, Gian Paolo Bugianesi, Elisabetta TI Impact of Chronotype and Mediterranean Diet on the Risk of Liver Fibrosis in Patients with Non-Alcoholic Fatty Liver Disease SO NUTRIENTS LA English DT Article DE chronotype; non-alcoholic fatty liver disease; liver fibrosis; Mediterranean diet ID LIFE-STYLE; EVENING CHRONOTYPE; SLEEP; NAFLD; ASSOCIATION; MANAGEMENT; DISORDERS; DIAGNOSIS; CLOCKS; NASH AB Late chronotype, the individual's aptitude to perform daily activities late in the day, has been associated with low adherence to the Mediterranean diet (MedDiet) and metabolic syndrome. The aim of this work was to investigate the potential association of chronotype and adherence to the MedDiet with the liver fibrosis risk in patients with non-alcoholic fatty liver disease (NAFLD). Liver stiffness was assessed in 126 patients by FibroScan(& REG;)530. Significant (F & GE; 2) and advanced (F & GE; 3) hepatic fibrosis were defined according to liver stiffness values & GE;7.1 kPa and & GE;8.8 kPa, respectively. Chronotype (MSFsc) was defined by the Munich Chronotype Questionnaire, and adherence to the MedDiet was defined by the Mediterranean diet score (MDS). Overall, the median age was 55 (46-63) years, and 57.9% of participants were male. The principal comorbidities were type-2 diabetes mellitus (T2DM) (26.1%), arterial hypertension (53.1%), dyslipidaemia (63.4%), obstructive sleep apnoea (5.5%) and depression (5.5%). Most subjects (65.0%) had intermediate + late chronotype and showed higher mid-sleep on workdays (p < 0.001) and on work-free days (p < 0.001) compared to those with early chronotype. In the logistic regression model, intermediate + late chronotype (p = 0.024), MDS (p = 0.019) and T2DM (p = 0.004) were found to be significantly and independently associated with the risk of both F & GE; 2 And F & GE; 3. We observed that the intermediate + late chronotype and low adherence to the MedDiet were associated with both significant and advanced liver fibrosis in patients with NAFLD. C1 [Castelnuovo, Gabriele; Perez-Diaz-del-Campo, Nuria; Rosso, Chiara; Guariglia, Marta; Armandi, Angelo; Nicolosi, Aurora; Caviglia, Gian Paolo; Bugianesi, Elisabetta] Univ Turin, Dept Med Sci, I-10126 Turin, Italy. [Armandi, Angelo] Univ Med Ctr Johannes Gutenberg, Dept Med 1, Metab Liver Dis Res Program, D-55131 Mainz, Germany. [Bugianesi, Elisabetta] Citta Salute & Sci Molinette Hosp, Gastroenterol Unit, I-10126 Turin, Italy. C3 University of Turin; Johannes Gutenberg University of Mainz; A.O.U. Citta della Salute e della Scienza di Torino; AOU San Giovanni Battista-Molinette RP Perez-Diaz-del-Campo, N; Bugianesi, E (通讯作者)，Univ Turin, Dept Med Sci, I-10126 Turin, Italy.; Bugianesi, E (通讯作者)，Citta Salute & Sci Molinette Hosp, Gastroenterol Unit, I-10126 Turin, Italy. EM gabriele.castelnuovo@unito.it; nuria.perezdiazdelcampo@unito.it; chiara.rosso@unito.it; marta.guariglia@unito.it; angelo.armandi@unito.it; aurora.nicolosi@unito.it; gianpaolo.caviglia@unito.it; elisabetta.bugianesi@unito.it RI Rosso, Chiara/AAY-4336-2021; Castelnuovo, Gabriele/HHS-5728-2022; Bugianesi, Elisabetta/K-8008-2016; Pérez Díaz del Campo, Nuria/HGC-4070-2022; Caviglia, Gian Paolo/H-6076-2012; Armandi, Angelo/AAU-6395-2020 OI Rosso, Chiara/0000-0001-6518-7089; Castelnuovo, Gabriele/0000-0002-9985-1440; Bugianesi, Elisabetta/0000-0002-0502-4381; Pérez Díaz del Campo, Nuria/0000-0003-0479-8825; Caviglia, Gian Paolo/0000-0002-0529-9481; Armandi, Angelo/0000-0002-7245-4445 FU University of Turin [ROSC_RILO_21_01]; Italian Ministry for Education, University and Research (Ministero dell'Istruzione, dell'Universita e della RicercaMIUR)- [D15D18000410001] FX The research was funded by the University of Turin, grant number ROSC_RILO_21_01 and by the Italian Ministry for Education, University and Research (Ministero dell'Istruzione, dell'Universita e della Ricerca-MIUR) under the programme "Dipartimenti di Eccellenza 2018-2022" Project code D15D18000410001. 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Misciagna, Giovanni Bonfiglio, Caterina Mirizzi, Antonella Franco, Isabella Bianco, Antonella Sorino, Paolo Caruso, Maria G. Cisternino, Anna M. Buongiorno, Claudia Liuzzi, Rosalba Osella, Alberto R. TI The Effect of Three Mediterranean Diets on Remnant Cholesterol and Non-Alcoholic Fatty Liver Disease: A Secondary Analysis SO NUTRIENTS LA English DT Article DE fasting REM-C levels; NAFLD severity score; insulin resistance ID DENSITY-LIPOPROTEIN CHOLESTEROL; TRIGLYCERIDE-RICH LIPOPROTEINS; NONFASTING TRIGLYCERIDES; CARDIOVASCULAR-DISEASE; INSULIN-RESISTANCE; LDL CHOLESTEROL; ADEQUACY INDEX; BLOOD-PRESSURE; HEART-DISEASE; SERUM-LIPIDS AB Background: Elevated fasting remnant cholesterol (REM-C) levels have been associated with an increased cardiovascular risk in patients with metabolic syndrome (Mets) and Non-Alcoholic Fatty Liver Disease (NAFLD). We aimed to estimate the effect of different diets on REM-C levels in patients with MetS, as well as the association between NAFLD and REM-C. Methods: This is a secondary analysis of the MEDIDIET study, a parallel-arm Randomized Clinical Trial (RCT). We examined 237 people with MetS who underwent Liver Ultrasound (LUS) to assess the NAFLD score at baseline, 3-, and 6-months follow-up. Subjects were randomly assigned to the Mediterranean diet (MD), Low Glycemic Index diet (LGID), or Low Glycemic Index Mediterranean diet (LGIMD). REM-C was calculated as [total cholesterol-low density lipoprotein cholesterol (LDL-C)-high density lipoprotein cholesterol (HDL-C)]. Results: REM-C levels were higher in subjects with moderate or severe NAFLD than in mild or absent ones. All diets had a direct effect in lowering the levels of REM-C after 3 and 6 months of intervention. In adherents subjects, this effect was stronger among LGIMD as compared to the control group. There was also a significant increase in REM-C levels among Severe NAFLD subjects at 3 months and a decrease at 6 months. Conclusions: fasting REM-C level is independently associated with the grade of severity of NAFLD. LGIMD adherence directly reduced the fasting REM-C in patients with MetS. C1 [Campanella, Angelo; Bonfiglio, Caterina; Mirizzi, Antonella; Franco, Isabella; Bianco, Antonella; Sorino, Paolo; Buongiorno, Claudia; Liuzzi, Rosalba; Osella, Alberto R.] S de Bellis Res Hosp, Natl Inst Gastroenterol, Lab Epidemiol & Biostat, Via Turi 27, I-70013 Castellana Grotte, Italy. [Iacovazzi, Palma A.] S de Bellis Res Hosp, Natl Inst Gastroenterol, Dept Clin Pathol, Via Turi 27, I-70013 Castellana Grotte, Italy. [Misciagna, Giovanni] Univ Hosp Policlin, Sci & Eth Comm, I-70124 Bari, Italy. [Caruso, Maria G.; Cisternino, Anna M.] S de Bellis Res Hosp, Natl Inst Gastroenterol, Ambulatory Clin Nutr, Via Turi 27, I-70013 Castellana Grotte, Italy. C3 Universita degli Studi di Bari Aldo Moro RP Osella, AR (通讯作者)，S de Bellis Res Hosp, Natl Inst Gastroenterol, Lab Epidemiol & Biostat, Via Turi 27, I-70013 Castellana Grotte, Italy. EM angelocampanella7@gmail.com; mina.iacovazzi@irccsdebellis.it; gmisciag@libero.it; catia.bonfiglio@irccsdebellis.it; antonella.mirizzi@irccsdebellis.it; isabella.franco@irccsdebellis.it; antonella.bianco@irccsdebellis.it; paolosorino96@libero.it; gabriella.caruso@irccsdebellis.it; annamaria.cisternino@irccsdebellis.it; buongiorno.claudia@gmail.com; liuzzirosalba@libero.it; arosella@irccsdebellis.it RI ; Osella, Alberto/M-6888-2014; Sorino, Paolo/JFS-3040-2023 OI Caruso, Maria Gabriella/0000-0003-4518-6307; Osella, Alberto/0000-0003-4232-8760; Campanella, Angelo/0000-0002-5044-4625; Buongiorno, Claudia/0000-0003-2689-1086; Liuzzi, Rosalba/0000-0003-1269-2916; Sorino, Paolo/0000-0002-9081-2648 FU Apulia Region [1159]; Italian Minister of Health RC 2019 [748] FX The study was supported by The Italian Minister of Health RC 2019 D.D.G. n. 748 11 October 2018 and by Apulia Region-D.G.R. n. 1159, 28 June 2018 and 2019. 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Anstee, Quentin M. TI The effectiveness and acceptability of Mediterranean diet and calorie restriction in non-alcoholic fatty liver disease (NAFLD): A systematic review and meta-analysis SO CLINICAL NUTRITION LA English DT Review DE Non-alcoholic fatty liver disease; Systematic review; Diet therapy; Reducing diet; Mediterranean diet ID LIFE-STYLE INTERVENTIONS; HEPATIC STEATOSIS; FIBROSIS STAGE; STEATOHEPATITIS; PROGRESSION; OUTCOMES; PLACEBO; ADULTS; TRIAL AB Background & aims: Lifestyle interventions that focus on reduced energy intake and improved dietary pattern are the mainstay of non-alcoholic fatty liver disease (NAFLD) management. However, it remains unclear which dietary approaches are most beneficial and promote greatest adherence. We aimed to synthesise data from randomised and clinical controlled trials, describing the effects of Mediterranean Diet and Calorie Restriction interventions on NAFLD surrogate markers, in adults. Methods: We searched MEDLINE, Embase, Scopus, Web of Science, and Cochrane Central Register of Controlled Trials (October 2021). Study quality was assessed using the Cochrane Collaboration's tools: risk of bias for randomised controlled trials, and risk of bias in non-randomised studies of interventions. Meta-analyses were performed using a random effects model, and the I-2 statistic was used to assess heterogeneity. Results: Of 4041 records identified, 26 articles with 3037 participants met the inclusion criteria, including studies on calorie-restricted interventions (CRI) (n 9), Mediterranean diet (MD) interventions (n 13) and MD component interventions (n 4). Studies were heterogeneous regarding intervention components, assessment of liver status and diet outcomes. 3 studies reported zero attrition and mean attrition rate for the remaining 23 studies was 14%. Post-intervention meta-analyses revealed that dietary interventions reduced alanine aminotransferase (ALT) (P < 0.001), aspartate aminotransferase (AST) (P = 0.004), Fatty Liver Index (FLI) (P < 0.001), hepatic steatosis (HS) (P = 0.02), and liver stiffness (P = 0.01). CRI had favourable effects on ALT (P < 0.001), HS (P < 0.001) and liver stiffness (P = 0.009). MD reduced ALT (P = 0.02), FLI (P < 0.001) and liver stiffness (P = 0.05). There was a doseeresponse relationship between degree of calorie restriction and beneficial effects on liver function and weight loss, suggesting that this approach should remain the cornerstone of NAFLD management. In addition, diet composition changes have potential for improving NAFLD and the limited data suggest that MD may be an effective diet therapy. Conclusion: These results support the current guidelines in NAFLD. However, further studies, which robustly evaluate the effects of interventions on dietary intake, acceptability and sustainability of the interventions, and quality of life and other patient-related outcomes are needed to support effective care delivery. (c) 2022 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). C1 [Haigh, Laura; Kirk, Colette; Gallacher, Jennifer; Anstee, Quentin M.] Newcastle Upon Tyne Hosp NHS Fdn Trust, Newcastle NIHR Biomed Res Ctr, Newcastle Upon Tyne NE4 5PL, Tyne & Wear, England. [Haigh, Laura; Kirk, Colette; Gallacher, Jennifer; Anstee, Quentin M.] Newcastle Univ, Fac Med Sci, Translat & Clin Res Inst, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England. [Haigh, Laura; Kirk, Colette; El Gendy, Khalil; Mathers, John C.] Newcastle Univ, Fac Med Sci, Populat Hlth Sci Inst, Human Nutr Res Ctr, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England. [Errington, Linda] Newcastle Univ, Fac Med Sci, Biomed Nutr & Sport Sci, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England. C3 Newcastle Upon Tyne Hospitals NHS Foundation Trust; Newcastle University - UK; Newcastle University - UK; Newcastle University - UK RP Haigh, L (通讯作者)，Newcastle Univ, Fac Med Sci, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England. EM l.haigh3@newcastle.ac.uk RI ; Anstee, Quentin M/L-2981-2013 OI Haigh, Laura/0000-0002-9229-4127; Mathers, John/0000-0003-3406-3002; Anstee, Quentin M/0000-0002-9518-0088; Kirk, Colette/0000-0003-4378-2703; Kirk, Colette/0000-0001-5648-7725 FU NIHR Newcastle Biomedical Research Centre (BRC) [BRC-1215-20001]; National Institute for Health and Care Research (NIHR); Innovative Medicines Initiative (IMI2) Program of the European Union [777377] FX This research was funded by the NIHR Newcastle Biomedical Research Centre (BRC) (grant number BRC-1215-20001). The NIHR Newcastle Biomedical Research Centre (BRC) is a partnership between Newcastle Hospitals NHS Foundation Trust and Newcastle University, funded by the National Institute for Health and Care Research (NIHR). The views expressed are those of the authors and not necessarily those of the NIHR or the Department of Health and Social Care. QMA is a member of the LITMUS (Liver Investigation: Testing Marker Utility in Steatohepatitis) consortium funded by the Innovative Medicines Initiative (IMI2) Program of the European Union (Grant Agreement 777377). 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Nutr. PD SEP PY 2022 VL 41 IS 9 BP 1913 EP 1931 DI 10.1016/j.clnu.2022.06.037 PG 19 WC Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Nutrition & Dietetics GA 7P0JD UT WOS:000908399500006 PM 35947894 OA hybrid HC Y HP N DA 2026-02-02 ER PT J AU Abenavoli, L Boccuto, L Federico, A Dallio, M Loguercio, C Di Renzo, L De Lorenzo, A AF Abenavoli, Ludovico Boccuto, Luigi Federico, Alessandro Dallio, Marcello Loguercio, Carmelina Di Renzo, Laura De Lorenzo, Antonino TI Diet and Non-Alcoholic Fatty Liver Disease: The Mediterranean Way SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH LA English DT Review DE metabolism; steatosis; inflammation; polyphenols; microbiota ID INFLAMMATORY GENE-EXPRESSION; ADEQUACY INDEX; HEALTHY-SUBJECTS; NAFLD; POPULATION; MANAGEMENT; OBESITY; MEAL; LDL AB Lifestyle interventions remain the first-line treatment for non-alcoholic fatty liver disease (NAFLD), even if the optimal alimentary regimen is still controversial. The interest in antioxidants has increased over time, and literature reports an inverse association between nutrients rich in antioxidants and the risk of mortality due to non-communicable diseases, including NAFLD. Mediterranean diet (MD) is a model characterized by main consumption of plant-based foods and fish and reduced consumption of meat and dairy products. MD represents the gold standard in preventive medicine, probably due to the harmonic combination of many foods with antioxidant and anti-inflammatory properties. This regimen contributes substantially to the reduction of the onset of many chronic diseases as cardiovascular diseases, hypertension, type 2 diabetes mellitus, obesity, cancer, and NAFLD. The present review aims to clarify the intake of antioxidants typical of the MD and evaluate their effect on NAFLD. C1 [Abenavoli, Ludovico] Magna Graecia Univ Catanzaro, Dept Hlth Sci, Viale Europa Germaneto, I-88110 Catanzaro, Italy. [Boccuto, Luigi] Greenwood Genet Ctr, 113 Gregor Mendel Circle, Greenwood, SC 29646 USA. [Federico, Alessandro; Dallio, Marcello; Loguercio, Carmelina] Univ Campania Luigi Vanvitelli, Dept Precis Med, Via Pansini 5, I-80131 Naples, Italy. [Di Renzo, Laura; De Lorenzo, Antonino] Univ Roma Tor Vergata, Sect Clin Nutr & Nutrigen, Dept Biomed & Prevent, Via Montpellier 1, I-00133 Rome, Italy. C3 Magna Graecia University of Catanzaro; Greenwood Genetic Center; Universita della Campania Vanvitelli; University of Rome Tor Vergata RP Abenavoli, L (通讯作者)，Magna Graecia Univ Catanzaro, Dept Hlth Sci, Viale Europa Germaneto, I-88110 Catanzaro, Italy. 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J. Environ. Res. Public Health PD SEP 1 PY 2019 VL 16 IS 17 AR 3011 DI 10.3390/ijerph16173011 PG 9 WC Environmental Sciences; Public, Environmental & Occupational Health WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI) SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA IZ4EQ UT WOS:000487037500006 PM 31438482 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Perez-Diaz-del-Campo, N Castelnuovo, G Rosso, C Nicolosi, A Guariglia, M Dileo, E Armandi, A Caviglia, GP Bugianesi, E AF Perez-Diaz-del-Campo, Nuria Castelnuovo, Gabriele Rosso, Chiara Nicolosi, Aurora Guariglia, Marta Dileo, Eleonora Armandi, Angelo Caviglia, Gian Paolo Bugianesi, Elisabetta TI Impact of Health Related QoL and Mediterranean Diet on Liver Fibrosis in Patients with NAFLD SO NUTRIENTS LA English DT Article DE Health related QoL; mediterranean diet; NAFLD; liver fibrosis ID DISEASE; LIFE AB Patients with non-alcoholic fatty liver disease (NAFLD) display impaired health-related quality of life (HRQoL) that is often linked to an unhealthy dietary pattern. The aim of this work was to investigate the impact of HRQoL and adherence to the Mediterranean diet on the risk of liver fibrosis (LF) in patients with NAFLD. LF was assessed in 244 patients through transient elastography (FibroScan(& REG;)530. Echosens, Paris, France). Significant LF was defined according to liver stiffness measurements (LSM) values & GE; 7.1 kPa. The Mediterranean diet score and the Short Form-36 questionnaires were also completed. The median age was 54 (44-62) years and 57% of participants were male. A total of 42 (17.2%) participants had LSM & GE; 7.1 kPa and showed increased GGT (p = 0.001), glucose (p < 0.001), and triglycerides levels (p = 0.015) compared to those with LSM & LE;7.0 kPa. Moreover, patients with significant LF had significantly lower scores related to Physical Functioning (p < 0.001) and Role Physical (p < 0.001). In the logistic regression analysis, lower role physical and lower adherence to the MedDiet (p = 0.001 and p = 0.009, respectively), after adjusting for age, diabetes, and obstructive sleep apnea, were associated with an increased risk of significant LF. Low adherence to MedDiet and low role physical may influence the risk of significant liver fibrosis in patients with NAFLD. C1 [Perez-Diaz-del-Campo, Nuria; Castelnuovo, Gabriele; Rosso, Chiara; Nicolosi, Aurora; Guariglia, Marta; Dileo, Eleonora; Armandi, Angelo; Caviglia, Gian Paolo; Bugianesi, Elisabetta] Univ Turin, Dept Med Sci, I-10126 Turin, Italy. [Armandi, Angelo] Johannes Gutenberg Univ Mainz, Univ Med Ctr, Dept Med 1, Metab Liver Dis Res Program, D-55131 Mainz, Germany. [Bugianesi, Elisabetta] Citta Salute & Sci Molinette Hosp, Gastroenterol Unit, I-10126 Turin, Italy. C3 University of Turin; Johannes Gutenberg University of Mainz; A.O.U. Citta della Salute e della Scienza di Torino; AOU San Giovanni Battista-Molinette RP Bugianesi, E (通讯作者)，Univ Turin, Dept Med Sci, I-10126 Turin, Italy.; Bugianesi, E (通讯作者)，Citta Salute & Sci Molinette Hosp, Gastroenterol Unit, I-10126 Turin, Italy. EM nuria.perezdiazdelcampo@unito.it; gabriele.castelnuovo@unito.it; chiara.rosso@unito.it; aurora.nicolosi@unito.it; marta.guariglia@unito.it; eleonora.dileo@unito.it; angelo.armandi@unito.it; gianpaolo.caviglia@unito.it; elisabetta.bugianesi@unito.it RI Pérez Díaz del Campo, Nuria/HGC-4070-2022; Armandi, Angelo/AAU-6395-2020; Bugianesi, Elisabetta/K-8008-2016; Caviglia, Gian Paolo/H-6076-2012; Rosso, Chiara/AAY-4336-2021; Castelnuovo, Gabriele/HHS-5728-2022 OI Pérez Díaz del Campo, Nuria/0000-0003-0479-8825; Armandi, Angelo/0000-0002-7245-4445; Bugianesi, Elisabetta/0000-0002-0502-4381; Caviglia, Gian Paolo/0000-0002-0529-9481; Rosso, Chiara/0000-0001-6518-7089; Castelnuovo, Gabriele/0000-0002-9985-1440; , Eleonora Dileo/0009-0006-4970-7762 FU University of Turin [ROSC_RILO_21_01]; Italian Ministry for Education; University and Research (Ministero dell'Istruzione, dell'Universita e della Ricerca-MIUR) [D15D18000410001] FX This research was funded by the University of Turin, grant number ROSC_RILO_21_01 and by the Italian Ministry for Education, University and Research (Ministero dell'Istruzione, dell'Universita e della Ricerca-MIUR) under the program "Dipartimenti di Eccellenza 2018-2022" Project code D15D18000410001. 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Caramia, D. V. Bonfiglio, C. Franco, I. Noviello, M. R. Chiloiro, M. Abbrescia, D. I. Mirizzi, A. Tanzi, M. Caruso, M. G. Correale, M. Reddavide, R. Inguaggiato, R. Cisternino, A. M. Osella, A. R. TI Effect of a low glycemic index Mediterranean diet on non-alcoholic fatty liver disease. A randomized controlled clinici trial SO JOURNAL OF NUTRITION HEALTH & AGING LA English DT Article DE Hepatic steatosis; Mediterranean diet; low glycemic index Mediterranean diet ID INSULIN-RESISTANCE; METABOLIC SYNDROME; HEPATIC STEATOSIS; GENERAL-POPULATION; ADEQUACY INDEX; WEIGHT-LOSS; STEATOHEPATITIS; RATS; INTERVENTION; METAANALYSIS AB Non-Alcoholic Fatty Liver Disease (NAFLD) is currently the most common form of liver disease worldwide affecting all ages and ethnic groups and it has become a consistent threat even in young people. Our aim was to estimate the effect of a Low Glycemic Index Mediterranean Diet (LGIMD) on the NAFLD score as measured by a Liver Ultrasonography (LUS). NUTRIzione in EPAtologia (NUTRIEPA) is a population-based Double-Blind RCT. Data were collected in 2011 and analyzed in 2013-14. 98 men and women coming from Putignano (Puglia, Southern Italy) were drawn from a previous randomly sampled population-based study and identified as having moderate or severe NAFLD. The intervention strategy was the assignment of a LGIMD or a control diet. The main outcome measure was NAFLD score, defined by LUS. After randomization, 50 subjects were assigned to a LGIMD and 48 to a control diet. The study lasted six months and all participants were subject to monthly controls/checks. Adherence to the LGIMD as measured by Mediterranean Adequacy Index (MAI) showed a median of 10.1. A negative interaction between time and LGIMD on the NAFLD score (-4.14, 95% CI -6.78,-1.49) was observed, and became more evident at the sixth month (-4.43, 95%CI -7.15, -1.71). A positive effect of the interaction among LGIMD, time and age (Third month: 0.07, 95% CI 0.02, 0.12; Sixth month: 0.08, 95% CI 0.03,0.13) was also observed. LGIMD was found to decrease the NAFLD score in a relatively short time. Encouraging those subjects who do not seek medical attention but still have NAFLD to follow a LGIMD and other life-style interventions, may reduce the degree of severity of the disease. Dietary intervention of this kind, could also form the cornerstone of primary prevention of Type 2 Diabetes Mellitus (T2DM) and cardiovascular disease. C1 [Misciagna, G.; Caramia, D. V.; Bonfiglio, C.; Franco, I.; Abbrescia, D. I.; Mirizzi, A.; Tanzi, M.; Osella, A. R.] IRCCS, Lab Epidemiol & Biostat, Castellana Grotte, BA, Italy. [Noviello, M. R.; Chiloiro, M.] IRCCS, Dept Radiol, Castellana Grotte, BA, Italy. [Caruso, M. G.] IRCCS, Lab Biochem Nutr, Castellana Grotte, BA, Italy. [Caruso, M. G.; Reddavide, R.; Inguaggiato, R.; Cisternino, A. M.] IRCCS, Clin Nutr Outpatient Clin, Castellana Grotte, BA, Italy. [Correale, M.] IRCCS, Clin Chem Lab, Castellana Grotte, BA, Italy. [del Pilar Diaz, M.] Consejo Nacl Invest Cient & Tecn, Inst Invest Ciencias Salud INICSA, Cordoba, Spain. [del Pilar Diaz, M.] Univ Nacl Cordoba, Fac Ciencias Med, Cordoba, Spain. C3 IRCCS Saverio de Bellis; IRCCS Saverio de Bellis; IRCCS Saverio de Bellis; IRCCS Saverio de Bellis; IRCCS Saverio de Bellis RP Osella, AR (通讯作者)，IRCCS Saverio Bellis, Lab Epidemiol & Biostat, Via Turi 27, I-70013 Castellana Grotte, BA, Italy. EM arosella@irccsdebellis.it RI ; Osella, Alberto/M-6888-2014 OI Abbrescia, Daniela Isabel/0000-0001-6303-0969; Osella, Alberto/0000-0003-4232-8760 FU Italian Ministry of Health FX ARO has no conflict of interest to declare. GM has no conflict of interest to declare. DMdP has no conflict of interest to declare. DVC has no conflict of interest to declare. CB has no conflict of interest to declare. IF has no conflict of interest to declare. MRN has no conflict of interest to declare. MC has no conflict of interest to declare. DIA has no conflict of interest to declare. AM has no conflict of interest to declare. MT has no conflict of interest to declare. MGC has no conflict of interest to declare. MC has no conflict of interest to declare. RR has no conflict of interest to declare. RI has no conflict of interest to declare. AMC has no conflict of interest to declare. All authors declare that this study was funded by a research grant from the Italian Ministry of Health. Role of the funding source: none. 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Nutr. Health Aging PD APR PY 2017 VL 21 IS 4 BP 404 EP 412 DI 10.1007/s12603-016-0809-8 PG 9 WC Geriatrics & Gerontology; Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Geriatrics & Gerontology; Nutrition & Dietetics GA ER7RH UT WOS:000399010700007 PM 28346567 DA 2026-02-02 ER PT J AU Janota, B Szymanek, B AF Janota, Barbara Szymanek, Barbara TI The Influence of Diet and Its Components on the Development and Prevention of Hepatocellular Carcinoma (HCC) SO CANCERS LA English DT Review DE hepatocellular carcinoma; diet; lifestyle; nutrients ID LIVER-CANCER; NAFLD; CELLS; RISK AB Simple Summary Due to the increasing incidence of hepatocellular carcinoma, which is a global problem, it is valuable to present the latest available literature that describes dietary options for preventing the development of hepatocellular carcinoma and the possibilities of dietary therapy for oncological patients. The authors firstly focus on discussing Metabolic Dysfunction-Associated Steatotic Liver Disease as a factor induced by improper dietary habits, while simultaneously suggesting the adoption of a Mediterranean diet as a model to counteract metabolic disorders resulting in HCC development. Subsequently, the authors discuss the potential for dietary modulation of autophagy processes, the necessity of supporting microbiota, the importance of providing selected vitamins and minerals, as well as compounds particularly valued for their anti-cancer properties, also observed in the case of HCC. The last aspect addressed is the consumption of products contributing to anti-tumor activity.Abstract Hepatocellular carcinoma (HCC) is diagnosed annually in nearly a million people worldwide, with approximately half of them being diagnosed at an advanced stage of the disease. Non-infectious risk factors for the development of HCC include an unbalanced lifestyle, including poor dietary choices characterized by a low intake of antioxidants, such as vitamins E and C, selenium, and polyphenols, as well as an excessive consumption of energy and harmful substances. Repeated bad dietary choices that contribute to an unbalanced lifestyle lead to the accumulation of fatty substances in the liver and to it entering an inflammatory state, which, without intervention, results in cirrhosis, the main cause of HCC. This review of the English language literature aims to present the food components that, when included in the daily diet, reduce the risk of developing HCC, as well as identifying foods that may have a carcinogenic effect on liver cells. C1 [Janota, Barbara] Med Univ Silesia, Fac Publ Hlth Bytom, Dept Basic Med Sci, PL-41902 Bytom, Poland. [Szymanek, Barbara] ID Clin, PL-41400 Myslowice, Poland. C3 Medical University of Silesia RP Janota, B (通讯作者)，Med Univ Silesia, Fac Publ Hlth Bytom, Dept Basic Med Sci, PL-41902 Bytom, Poland. 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Lal, BB Khanna, R Alam, S Sarin, SK AF Deshmukh, Aniket Sood, Vikrant Lal, Bikrant Bihari Khanna, Rajeev Alam, Seema Sarin, Shiv Kumar TI Effect of Indo-Mediterranean diet versus calorie-restricted diet in children with non-alcoholic fatty liver disease: A pilot randomized control trial SO PEDIATRIC OBESITY LA English DT Article DE Controlled attenuation parameter; Indo-Mediterranean Diet; liver stiffness measurement; non-alcoholic fatty liver disease; non-alcoholic steatohepatitis; transient elastography ID HEPATIC STEATOSIS; MANAGEMENT; DIAGNOSIS; RISK AB BackgroundDietary interventions and increased physical activity are the cornerstones for management of the paediatric non-alcoholic fatty liver disease (NAFLD). Though, no specific diet has been proven superior, Indo-Mediterranean diet (IMD) has shown promise in adult literature. Thus, we aimed to compare the effect of IMD and a standard calorie-restricted diet (CRD) in Indian overweight children and adolescents with biopsy-proven NAFLD. MethodsThirty-nine consecutive biopsy-proven NAFLD children between the ages of 8 and 18 years were randomized into either IMD or CRD for 180 days, and various parameters were evaluated at baseline and then after 180 days (NCT05073588). ResultsA total of 34 subjects (18 in IMD and 16 in CRD group) completed the study. There was a significantly higher decrease in controlled attenuation parameter (CAP) values (as a marker of hepatic steatosis; on transient elastography) (95% CI: 4.2-73.4, p = 0.042), weight (95% CI: 0.75-5.5, p = 0.046) and body mass index (BMI) (95% CI: 0.21-2.05, p = 0.014) (but not in Pediatric NAFLD Fibrosis Index or PNFI; as a marker of hepatic fibrosis) in IMD group compared to the CRD group. Liver stiffness measurement, serum cholesterol and low-density lipoprotein levels and HOMA-IR decreased only in the IMD group (p < 0.001). Our statistical model showed that delta-Weight was the only independent variable associated with delta-CAP. ConclusionBoth IMD and CRD can improve the various anthropometric, clinical, imaging and biochemical parameters but IMD was superior to CRD in terms of reducing CAP values and weight/BMI over 180 days in overweight/obese NAFLD children. C1 [Deshmukh, Aniket; Sood, Vikrant; Lal, Bikrant Bihari; Khanna, Rajeev; Alam, Seema] Inst Liver & Biliary Sci, Dept Pediat Hepatol, New Delhi 110070, India. [Sarin, Shiv Kumar] Inst Liver & Biliary Sci, Dept Hepatol, New Delhi, India. C3 Institute of Liver & Biliary Sciences (ILBS); Institute of Liver & Biliary Sciences (ILBS) RP Alam, S (通讯作者)，Inst Liver & Biliary Sci, Dept Pediat Hepatol, New Delhi 110070, India. 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Obes. PD NOV PY 2024 VL 19 IS 11 SI SI DI 10.1111/ijpo.13163 EA SEP 2024 PG 8 WC Pediatrics WE Science Citation Index Expanded (SCI-EXPANDED) SC Pediatrics GA J4E1P UT WOS:001303876000001 PM 39223952 DA 2026-02-02 ER PT J AU Bonfiglio, C Campanella, A Donghia, R Bianco, A Franco, I Curci, R Bagnato, CB Tatoli, R Giannelli, G Cuccaro, F AF Bonfiglio, Caterina Campanella, Angelo Donghia, Rossella Bianco, Antonella Franco, Isabella Curci, Ritanna Bagnato, Claudia Beatrice Tatoli, Rossella Giannelli, Gianluigi Cuccaro, Francesco TI Development and Internal Validation of a Model for Predicting Overall Survival in Subjects with MAFLD: A Cohort Study SO JOURNAL OF CLINICAL MEDICINE LA English DT Article DE prognostic index; MAFLD; mortality ID FATTY LIVER-DISEASE; MEDITERRANEAN DIET; EPIDEMIOLOGY; POPULATION; MORTALITY; SELECTION; BEER; RISK; WINE AB Background & Aims: Fatty liver disease with metabolic dysfunction (MAFLD) is a new concept proposed to replace the previous concept of Non-Alcoholic Hepatic Steatosis (NAFLD). We developed and internally validated a prognostic model to predict the likelihood of death in a cohort of subjects with MAFLD. Methods: Our work involved two steps: the first was the construction of a bootstrapped multivariable Cox model for mortality risk prognosis and the second was its validation. Results: The study cohort included 1506 subjects, of which 907 were used for internal validation. Discriminant measures for the final model were R2D 0.6845 and Harrell's C 0.8422 in the development and R2D 0.6930 and Harrell's C 0.8465 in the validation. We used the nine independent prognostic factors selected by the LASSO Cox procedure and fitted by the bootstrap Cox survival model, and observed beta were: Gender 0.356 1.42 (p < 0.008), Age 0.146 (p < 0.001), Glycemia 0.004 (p < 0.002), Total Cholesterol -0.0040 (p < 0.009), Gamma Glutamyl Transpeptidase 0.009 (p < 0.001), SBP 0.009 (p < 0.036), DBP -0.016 (p < 0.041), ALP 0.008 (p < 0.071) and Widowhood 0.550 (p < 0.001). Conclusions: We produced and validated a model to estimate the probability of death in subjects with MAFLD. The instruments we used showed satisfactory predictive capabilities. C1 [Bonfiglio, Caterina; Campanella, Angelo; Donghia, Rossella; Bianco, Antonella; Franco, Isabella; Curci, Ritanna; Bagnato, Claudia Beatrice; Tatoli, Rossella; Giannelli, Gianluigi] IRCCS S de Bellis, Natl Inst Gastroenterol, I-70013 Castellana Grotte, BA, Italy. [Cuccaro, Francesco] Andria Trani, Local Hlth Unit Barletta, I-76121 Barletta, Italy. C3 IRCCS Saverio de Bellis RP Bonfiglio, C (通讯作者)，IRCCS S de Bellis, Natl Inst Gastroenterol, I-70013 Castellana Grotte, BA, Italy. EM catia.bonfiglio@irccsdebellis.it; angelo.campanella@irccsdebellis.it; rossella.donghia@irccsdebellis.it; antonella.bianco@irccsdebellis.it; isabella.franco@irccsdebellis.it; ritanna.curci@irccsdebellis.it; claudia.bagnato@irccsdebellis.it; rossella.tatoli@irccsdebellis.it; gianluigi.giannelli@irccsdebellis.it; francescocuccaroepi@gmail.com RI ; Giannelli, Gianluigi/A-8169-2012; Forastiere, Francesco/J-9067-2016 OI Bonfiglio, Caterina/0000-0002-8650-348X; Giannelli, Gianluigi/0000-0002-5140-8060; FRANCO, ISABELLA/0000-0002-3697-0127; Tatoli, Rossella/0000-0002-7891-6057; Donghia, Rossella/0000-0002-9140-673X; Campanella, Angelo/0000-0002-5044-4625 FU Progetto Finalizzato del Ministero della Salute FX We would like to thank the MICOL and NUTRIHEP groups, Giovanni Misciagna, Alberto Ruben Osella, Maria Gabriella Caruso, Anna Maria Cisternino, Marisa Chiloiro, Onofrio Giuseppe Manghisi, and also all individual participants in the study. 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PD FEB PY 2024 VL 13 IS 4 AR 1181 DI 10.3390/jcm13041181 PG 14 WC Medicine, General & Internal WE Science Citation Index Expanded (SCI-EXPANDED) SC General & Internal Medicine GA JS4J1 UT WOS:001175136800001 PM 38398493 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Watanabe, M Tozzi, R Risi, R Tuccinardi, D Mariani, S Basciani, S Spera, G Lubrano, C Gnessi, L AF Watanabe, Mikiko Tozzi, Rossella Risi, Renata Tuccinardi, Dario Mariani, Stefania Basciani, Sabrina Spera, Giovanni Lubrano, Carla Gnessi, Lucio TI Beneficial effects of the ketogenic diet on nonalcoholic fatty liver disease: A comprehensive review of the literature SO OBESITY REVIEWS LA English DT Review DE liver steatosis; low carbohydrate diet; obesity; very low calorie diet ID LOW-CARBOHYDRATE DIET; HEPATIC STEATOSIS; LONG-TERM; WEIGHT-LOSS; BETA-HYDROXYBUTYRATE; MEDITERRANEAN DIET; INTERMITTENT; INFLAMMATION; RESTRICTION; OVERWEIGHT AB Nonalcoholic fatty liver disease (NAFLD) is a major cause of chronic liver disease, characterized by hepatic fat accumulation and possible development of inflammation, fibrosis, and cancer. The ketogenic diet (KD), with its drastic carbohydrate reduction, is a now popular weight loss intervention, despite safety concerns on a possible association with fatty liver. However, KDs were also reported to be beneficial on hepatic pathology, with ketone bodies recently proposed as effective modulators of inflammation and fibrosis. If the beneficial impact of weight loss on NAFLD is established, less is known on the effect of macronutrient distribution on such outcome. In a hypocaloric regimen, the latter seems not to be crucial, whereas at higher calorie intake, macronutrient ratio and, theoretically, ketosis, may become important. KDs could positively impact NAFLD for their very low carbohydrate content, and whether ketosis plays an additional role is unknown. Indeed, several mechanisms may directly link ketosis and NAFLD improvement, and elucidating these aspects would pave the way for new therapeutic strategies. We herein aimed at providing an accurate revision of current literature on KDs and NAFLD, focusing on clinical evidence, metabolic pathways involved, and strict categorization of dietary interventions. C1 [Watanabe, Mikiko; Risi, Renata; Mariani, Stefania; Basciani, Sabrina; Spera, Giovanni; Lubrano, Carla; Gnessi, Lucio] Sapienza Univ Rome, Sect Med Pathophysiol Food Sci & Endocrinol, Dept Expt Med, Rome, Italy. [Tozzi, Rossella] Sapienza Univ Rome, Dept Mol Med, Rome, Italy. [Tuccinardi, Dario] Univ Campus Biomed Rome, Dept Endocrinol & Diabet, Rome, Italy. C3 Sapienza University Rome; Sapienza University Rome; University Campus Bio-Medico - Rome Italy RP Watanabe, M (通讯作者)，Sapienza Univ Rome, Sect Med Pathophysiol Food Sci & Endocrinol, Dept Expt Med, Rome, Italy. EM mikiko.watanabe@uniroma1.it RI Gnessi, Lucio/K-8025-2016; Risi, Renata/ADC-1851-2022; Tuccinardi, Dario/AAN-9540-2020; Tozzi, Rossella/AAB-9253-2019; lubrano, carla/F-4419-2011; watanabe, mikiko/AAL-6316-2020 OI Tozzi, Rossella/0000-0002-3358-4204; watanabe, mikiko/0000-0003-2225-8814 FU New Penta s.r.l. FX New Penta s.r.l. made funding available for publication charges. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results. 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PD AUG PY 2020 VL 21 IS 8 DI 10.1111/obr.13024 EA MAR 2020 PG 11 WC Endocrinology & Metabolism WE Science Citation Index Expanded (SCI-EXPANDED) SC Endocrinology & Metabolism GA MM0XX UT WOS:000521079100001 PM 32207237 OA Green Submitted, hybrid DA 2026-02-02 ER PT J AU Zou, JH Tian, F Cui, SQ Hou, J Li, ZH Wei, YC Cui, HZ Li, YP Zhou, SH He, ZC Ma, XM AF Zou, Jiahui Tian, Fei Cui, Shuqing Hou, Jing Li, Zhenhua Wei, Yaochen Cui, Haozhe Li, Yunpeng Zhou, Shuanghao He, Zechao Ma, Xiangming TI Comparative efficacy of different diet modalities on metabolic profiles and liver functions in metabolic dysfunction-associated fatty liver disease: a network meta-analysis SO BMC GASTROENTEROLOGY LA English DT Review DE Metabolic dysfunction-associated fatty liver disease; Diet; RCTs; Network meta-analysis; Liver function ID MEDITERRANEAN DIET; HEPATIC STEATOSIS AB BackgroundMetabolic dysfunction-associated fatty liver disease (MAFLD) is a global public health challenge that is primarily managed through lifestyle interventions, particularly diet. This network meta-analysis aimed to thoroughly evaluate the effectiveness of four different dietary patterns: Mediterranean diet (MD), intermittent fasting (IF), Dietary Approaches to Stop Hypertension (DASH), and low-fat diet (LF) in improving liver function and metabolic profiles in adults diagnosed with MAFLD.MethodsIn accordance with the PRISMA guidelines, we conducted a search in PubMed, Embase, Web of Science, the Cochrane Library, ClinicalTrials.gov, and WHO-ICTRP for randomized controlled trials (RCTs) up to Oct. 19, 2025, and registered the study on PROSPERO (CRD42024609524). The Cochrane Risk of Bias Tool 2.0 was used to evaluate study quality, and the surface under the cumulative ranking curve (SUCRA) was used to rank the intervention effects.ResultsIF emerged as the most effective intervention for weight loss (WMD = -1.96 kg, 95% CI -3.01,-0.92) and reducing waist circumference (WMD = -1.73 cm, 95% CI -2.89,-0.57). Sensitivity analysis indicated that intensive IF regimens might drive stronger improvements than time-restricted feeding. The MD ranked highest for improving hepatic pathology, showing statistically significant reductions in intrahepatic lipid (IHL) (WMD = -1.68%, 95% CI -3.21, -0.16), and triglycerides (WMD = -22.54 mg/dL, 95% CI -42.79, -2.29).ConclusionsIF and MD demonstrate distinct therapeutic profiles for MAFLD. IF serves as a robust strategy for weight management, particularly with more intensive regimens. Conversely, the MD demonstrates potential as a favorable strategy for targeting hepatic steatosis and lipid metabolism disorders. Therefore, clinicians are advised to adopt a personalized strategy, tailoring dietary prescriptions to the patient's primary metabolic characteristics, pending validation from high-quality, long-term RCTs. C1 [Zou, Jiahui; Cui, Shuqing; Hou, Jing; Li, Zhenhua; Wei, Yaochen; Li, Yunpeng; Zhou, Shuanghao; He, Zechao; Ma, Xiangming] North China Univ Sci & Technol, Kailuan Gen Hosp, Dept Hepatobiliary Surg, Tangshan, Hebei, Peoples R China. [Tian, Fei] North China Univ Sci & Technol, Affiliated Hosp, Dept Tumor Chemoradiotherapy, Tangshan 063000, Hebei, Peoples R China. [Cui, Haozhe] Nankai Univ, Sch Med, Tianjin, Peoples R China. C3 North China University of Science & Technology; North China University of Science & Technology; Nankai University RP Ma, XM (通讯作者)，North China Univ Sci & Technol, Kailuan Gen Hosp, Dept Hepatobiliary Surg, Tangshan, Hebei, Peoples R China. EM brighter_ma@163.com FU the 2023 Talent Project of Tangshan City [B202302016] FX The author(s) declare that financial support was received for the research and/or publication of this article.This study was supported by the 2023 Talent Project of Tangshan City (B202302016). 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PD DEC 10 PY 2025 VL 26 IS 1 AR 25 DI 10.1186/s12876-025-04535-1 PG 11 WC Gastroenterology & Hepatology WE Science Citation Index Expanded (SCI-EXPANDED) SC Gastroenterology & Hepatology GA CB8PH UT WOS:001662074500002 PM 41372862 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Semmler, G Datz, C Reiberger, T Trauner, M AF Semmler, Georg Datz, Christian Reiberger, Thomas Trauner, Michael TI Diet and exercise in NAFLD/NASH: Beyond the obvious SO LIVER INTERNATIONAL LA English DT Review DE diet; lifestyle; non-alcoholic fatty liver disease; non-alcoholic steatohepatitis; nutrition; physical activity ID NONALCOHOLIC FATTY LIVER; LIFE-STYLE MODIFICATION; MODEST ALCOHOL-CONSUMPTION; WEIGHT-LOSS; MEDITERRANEAN DIET; HEPATIC STEATOSIS; PPAR-ALPHA; HEPATOCELLULAR-CARCINOMA; BETA-HYDROXYBUTYRATE; COFFEE CONSUMPTION AB Lifestyle represents the most relevant factor for non-alcoholic fatty liver disease (NAFLD) as the hepatic manifestation of the metabolic syndrome. Although a tremendous body of clinical and preclinical data on the effectiveness of dietary and lifestyle interventions exist, the complexity of this topic makes firm and evidence-based clinical recommendations for nutrition and exercise in NAFLD difficult. The aim of this review is to guide readers through the labyrinth of recent scientific findings on diet and exercise in NAFLD and non-alcoholic steatohepatitis (NASH), summarizing "obvious" findings in a holistic manner and simultaneously highlighting stimulating aspects of clinical and translational research "beyond the obvious". Specifically, the importance of calorie restriction regardless of dietary composition and evidence from low-carbohydrate diets to target the incidence and severity of NAFLD are discussed. The aspect of ketogenesis-potentially achieved via intermittent calorie restriction-seems to be a central aspect of these diets warranting further investigation. Interactions of diet and exercise with the gut microbiota and the individual genetic background need to be comprehensively understood in order to develop personalized dietary concepts and exercise strategies for patients with NAFLD/NASH. C1 [Semmler, Georg; Reiberger, Thomas; Trauner, Michael] Med Univ Vienna, Div Gastroenterol & Hepatol, Dept Internal Med 3, Wahringer Gurtel 18-20, A-1090 Vienna, Austria. [Datz, Christian] Paracelsus Med Univ Salzburg, Teaching Hosp, Gen Hosp Oberndorf, Dept Internal Med, Salzburg, Austria. C3 Medical University of Vienna; Paracelsus Private Medical University RP Trauner, M (通讯作者)，Med Univ Vienna, Div Gastroenterol & Hepatol, Dept Internal Med 3, Wahringer Gurtel 18-20, A-1090 Vienna, Austria. 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PD OCT PY 2021 VL 41 IS 10 BP 2249 EP 2268 DI 10.1111/liv.15024 EA AUG 2021 PG 20 WC Gastroenterology & Hepatology WE Science Citation Index Expanded (SCI-EXPANDED) SC Gastroenterology & Hepatology GA US6MY UT WOS:000686926800001 PM 34328248 OA Green Submitted DA 2026-02-02 ER PT J AU Oliveira, CP Sanches, PD de Abreu-Silva, EO Marcadenti, A AF Oliveira, Claudia P. Sanches, Priscila de Lima de Abreu-Silva, Erlon Oliveira Marcadenti, Aline TI Nutrition and Physical Activity in Nonalcoholic Fatty Liver Disease SO JOURNAL OF DIABETES RESEARCH LA English DT Review ID MODERATE ALCOHOL-CONSUMPTION; HEPATIC STEATOSIS; INSULIN-RESISTANCE; MEDITERRANEAN DIET; WEIGHT-LOSS; METABOLIC SYNDROME; OXIDATIVE STRESS; SKELETAL-MUSCLE; RISK-FACTORS; VITAMIN-E AB Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease worldwide and it is associated with other medical conditions such as diabetes mellitus, metabolic syndrome, and obesity. The mechanisms of the underlying disease development and progression are not completely established and there is no consensus concerning the pharmacological treatment. In the gold standard treatment for NAFLD weight loss, dietary therapy, and physical activity are included. However, little scientific evidence is available on diet and/or physical activity and NAFLD specifically. Many dietary approaches such asMediterranean and DASH diet are used for treatment of other cardiometabolic risk factors such as insulin resistance and type-2 diabetes mellitus (T2DM), but on the basis of its components their role in NAFLD has been discussed. In this review, the implications of current dietary and exercise approaches, including Brazilian and other guidelines, are discussed, with a focus on determining the optimal nonpharmacological treatment to prescribe for NAFLD. C1 [Oliveira, Claudia P.] Univ Sao Paulo, Sch Med, Dept Gastroenterol, BR-05403900 Sao Paulo, SP, Brazil. [Sanches, Priscila de Lima] Fed Univ Sao Paulo UNIFESP, Postgrad Program Nutr, BR-04020060 Sao Paulo, SP, Brazil. [de Abreu-Silva, Erlon Oliveira] Fed Univ Sao Paulo UNIFESP, Div Intervent Cardiol, BR-04024002 Sao Paulo, SP, Brazil. [de Abreu-Silva, Erlon Oliveira] Fed Univ Sao Paulo UNIFESP, Postgrad Program Cardiol, BR-04024002 Sao Paulo, SP, Brazil. [Marcadenti, Aline] Fed Univ Hlth Sci Porto Alegre UFCSPA, Dept Nutr, Ctr Hist, BR-90050170 Porto Alegre, RS, Brazil. [Marcadenti, Aline] Inst Cardiol Rio Grande do Sul IC FUC, Postgrad Program Hlth Sci Cardiol, BR-90040371 Porto Alegre, RS, Brazil. C3 Universidade de Sao Paulo; Universidade Federal de Sao Paulo (UNIFESP); Universidade Federal de Sao Paulo (UNIFESP); Universidade Federal de Sao Paulo (UNIFESP); Universidade Federal de Ciencias da Saude de Porto Alegre; Fundacao Universitaria de Cardiologia RP Marcadenti, A (通讯作者)，Fed Univ Hlth Sci Porto Alegre UFCSPA, Dept Nutr, Ctr Hist, 245 Sarmento Leite St, BR-90050170 Porto Alegre, RS, Brazil. 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Diabetes Res. PY 2016 VL 2016 AR 4597246 DI 10.1155/2016/4597246 PG 12 WC Endocrinology & Metabolism; Medicine, Research & Experimental WE Science Citation Index Expanded (SCI-EXPANDED) SC Endocrinology & Metabolism; Research & Experimental Medicine GA DB2VD UT WOS:000368367300001 PM 26770987 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Ryan, MC Itsiopoulos, C Thodis, T Ward, G Trost, N Hofferberth, S O'Dea, K Desmond, PV Johnson, NA Wilson, AM AF Ryan, Marno C. Itsiopoulos, Catherine Thodis, Tania Ward, Glenn Trost, Nicholas Hofferberth, Sophie O'Dea, Kerin Desmond, Paul V. Johnson, Nathan A. Wilson, Andrew M. TI The Mediterranean diet improves hepatic steatosis and insulin sensitivity in individuals with non-alcoholic fatty liver disease SO JOURNAL OF HEPATOLOGY LA English DT Article DE Liver fat; Cardiovascular risk; Diet; Fatty acids; Insulin resistance ID METABOLIC SYNDROME; AMINOTRANSFERASE LEVELS; RESISTANCE; GLUCOSE; RISK; CONSUMPTION; ADHERENCE; STEATOHEPATITIS; CARBOHYDRATE; ASSOCIATION AB Background & Aims: Non-alcoholic fatty liver disease (NAFLD) affects up to 30% of the population and signifies increased risk of liver fibrosis and cirrhosis, type 2 diabetes, and cardiovascular disease. Therapies are limited. Weight loss is of benefit but is difficult to maintain. We aimed at examining the effect of the Mediterranean diet (MD), a diet high in monounsaturated fatty acids, on steatosis and insulin sensitivity, using gold standard techniques. Methods: Twelve non-diabetic subjects (6 Females/6 Males) with biopsy-proven NAFLD were recruited for a randomised, crossover 6-week dietary intervention study. All subjects undertook both the MD and a control diet, a low fat-high carbohydrate diet (LF/HCD), in random order with a 6-week wash-out period in- between. Insulin sensitivity was determined with a 3-h hyperinsulinemic-euglycemic clamp study and hepatic steatosis was assessed with localized magnetic resonance H-1 spectroscopy (H-1-MRS). Results: At baseline, subjects were abdominally obese with elevated fasting concentrations of glucose, insulin, triglycerides, ALT, and GGT. Insulin sensitivity at baseline was low (M = 2.7 +/- 1.0 mg/kg/min(-1)). Mean weight loss was not different between the two diets (p = 0.22). There was a significant relative reduction in hepatic steatosis after the MD compared with the LF/HCD: 39 +/- 4% versus 7 +/- 3%, as measured by H-1-MRS (p = 0.012). Insulin sensitivity improved with the MD, whereas after the LF/HCD there was no change (p = 0.03 between diets). Conclusions: Even without weight loss, MD reduces liver steatosis and improves insulin sensitivity in an insulin-resistant population with NAFLD, compared to current dietary advice. This diet should be further investigated in subjects with NAFLD. (C) 2013 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved. C1 [Ryan, Marno C.; Desmond, Paul V.] St Vincents Hosp, Dept Gastroenterol, Melbourne, Vic, Australia. [Ryan, Marno C.; Itsiopoulos, Catherine; Thodis, Tania; Ward, Glenn; Hofferberth, Sophie; O'Dea, Kerin; Wilson, Andrew M.] St Vincents Hosp, Dept Med, Melbourne, Vic, Australia. [Trost, Nicholas] St Vincents Hosp, Dept Med Imaging, Melbourne, Vic, Australia. [Johnson, Nathan A.] Univ Sydney, Discipline Exercise & Sport Sci, Sydney, NSW 2006, Australia. [Johnson, Nathan A.] Univ Sydney, Boden Inst Obes Nutr Exercise & Eating Disorders, Sydney, NSW 2006, Australia. [Itsiopoulos, Catherine; Thodis, Tania] La Trobe Univ, Fac Hlth Sci, Dept Dietet & Human Nutr, Melbourne, Vic, Australia. [O'Dea, Kerin] Univ S Australia, Sansom Inst Hlth Res, Adelaide, SA 5001, Australia. C3 NSW Health; St Vincents Hospital Sydney; St Vincent's Health; St Vincent's Hospital Melbourne; NSW Health; St Vincents Hospital Sydney; St Vincent's Health; St Vincent's Hospital Melbourne; St Vincent's Health; St Vincent's Hospital Melbourne; NSW Health; St Vincents Hospital Sydney; University of Sydney; University of Sydney; La Trobe University; Adelaide University; University of South Australia RP Ryan, MC (通讯作者)，St Vincents Hosp, Dept Gastroenterol, Level 4 Daly Wing,41 Victoria Pde, Fitzroy, Vic 3065, Australia. EM Marno.Ryan@svhm.org.au RI ; Johnson, Nathan/Q-3158-2016; Thodis, Antonia/OCL-0101-2025; Wilson, Andrew/AAW-4889-2021; O'Dea, Kerin/B-6916-2009 OI Itsiopoulos, Catherine/0000-0003-1397-4149; Johnson, Nathan/0000-0002-3874-7092; Thodis, Antonia/0000-0003-1197-062X; FU NHMRC Neil Hamilton Fairley Fellowship; University of Melbourne FX M Ryan was supported by an NHMRC Neil Hamilton Fairley Fellowship. This project was also supported by an Early Career Researcher Grant from the University of Melbourne. 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Hepatol. PD JUL PY 2013 VL 59 IS 1 BP 138 EP 143 DI 10.1016/j.jhep.2013.02.012 PG 6 WC Gastroenterology & Hepatology WE Science Citation Index Expanded (SCI-EXPANDED) SC Gastroenterology & Hepatology GA 165KF UT WOS:000320482100022 PM 23485520 OA Green Submitted DA 2026-02-02 ER PT J AU Finer, N AF Finer, Nick TI Weight loss interventions and nonalcoholic fatty liver disease: Optimizing liver outcomes SO DIABETES OBESITY & METABOLISM LA English DT Article DE antiobesity drug; bariatric surgery; dietary intervention; exercise intervention; GLP-1 analogue; liver; nonalcoholic fatty liver disease ID MEDITERRANEAN DIET; BARIATRIC SURGERY; JEJUNOILEAL BYPASS; SLEEVE GASTRECTOMY; OBESITY; STEATOHEPATITIS; MANAGEMENT; ADHERENCE; GLP-1; ATHEROSCLEROSIS AB The growth in prevalence of obesity, type 2 diabetes and nonalcoholic fatty liver disease (NAFLD) has become one of the most important global health challenges. The three chronic diseases are closely linked in their epidemiology and pathophysiology. Currently, weight loss is the most effective treatment for NAFLD (even in the minority of patients with NAFLD who do not have obesity) and is recommended in all national and international guidelines. Accumulating evidence has shown that weight loss, whether achieved by diet and lifestyle interventions, bariatric surgery or pharmacotherapy, can improve biomarkers of NAFLD, as well as prevent progression and, in some cases, reverse fibrosis. There is a dose dependency of weight loss with NAFLD improvement. Pharmacotherapy with antiobesity medications, alone or in combination with intensive lifestyle interventions or other weight-loss drugs, is closing the efficacy gap between diet and exercise and weight-loss surgery in efficacy at reversing obesity. 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METAB JI Diabetes Obes. Metab. PD FEB PY 2022 VL 24 SU 2 BP 44 EP 54 DI 10.1111/dom.14569 EA OCT 2021 PG 11 WC Endocrinology & Metabolism WE Science Citation Index Expanded (SCI-EXPANDED) SC Endocrinology & Metabolism GA YX9JH UT WOS:000715107200001 PM 34622555 OA Bronze DA 2026-02-02 ER PT J AU Perdomo, CM Frühbeck, G Escalada, J AF Perdomo, Carolina M. Fruehbeck, Gema Escalada, Javier TI Impact of Nutritional Changes on Nonalcoholic Fatty Liver Disease SO NUTRIENTS LA English DT Review DE NAFLD; NASH; diet; macronutrients ID LIFE-STYLE INTERVENTIONS; MEDITERRANEAN DIET; HEPATIC STEATOSIS; LOW-CARBOHYDRATE; WEIGHT-LOSS; CLINICAL CHARACTERISTICS; CAFFEINE CONSUMPTION; INSULIN SENSITIVITY; ALCOHOL-CONSUMPTION; HIGH-FRUCTOSE AB Non-alcoholic fatty liver disease (NAFLD) is a major global health threat due to its growing incidence and prevalence. It is becoming the leading cause of liver disease in addition to its strong association with cardio-metabolic disease. Therefore, its prevention and treatment are of strong public interest. Therapeutic approaches emphasize lifestyle modifications including physical activity and the adoption of healthy eating habits that intend to mainly control body weight and cardio-metabolic risk factors associated with the metabolic syndrome. Lifestyle interventions may be reinforced by pharmacological treatment in advanced stages, though there is still no registered drug for the specific treatment of NAFLD. The purpose of this review is to assess the evidence available regarding the impact of dietary recommendations against NAFLD, highlighting the effect of macronutrient diet composition and dietary patterns in the management of NAFLD. C1 [Perdomo, Carolina M.; Fruehbeck, Gema; Escalada, Javier] Clin Univ Navarra, Dept Endocrinol & Nutr, Pamplona 31008, Spain. [Fruehbeck, Gema; Escalada, Javier] ISCIII, CIBER Fisiopatol Obesidad & Nutr CIBERobn, Madrid 28029, Spain. 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2019 VL 11 IS 3 AR 677 DI 10.3390/nu11030677 PG 25 WC Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Nutrition & Dietetics GA HT2AA UT WOS:000464364400001 PM 30901929 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Lange, NF Radu, P Dufour, JF AF Lange, Naomi F. Radu, Pompilia Dufour, Jean-Francois TI Prevention of NAFLD-associated HCC: Role of lifestyle and chemoprevention SO JOURNAL OF HEPATOLOGY LA English DT Article DE Non-alcoholic fatty liver disease; Non-alcoholic steatohepatitis; Hepatocellular carcinoma; Prevention; Lifestyle; Diet; Physical activity; Coffee; Alcohol; Aspirin; Statins; Probiotics ID FATTY LIVER-DISEASE; RANDOMIZED CONTROLLED-TRIAL; HEPATOCELLULAR-CARCINOMA; HEPATITIS-C; VIRAL-HEPATITIS; RISK-FACTORS; WEIGHT-LOSS; MEDITERRANEAN DIET; DIABETIC-PATIENTS; ALCOHOL-DRINKING AB In many countries worldwide, the burden of hepatocellular carcinoma (HCC) associated with nonalcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) is increasing. Preventive strategies are needed to counteract this trend. In this review, we provide an overview of the evidence on preventive strategies in NAFLD-associated HCC. We consider the impact of lifestyle factors such as weight loss, physical activity, smoking, dietary patterns and food items, including coffee and alcohol, on both HCC and NAFLD/NASH. Furthermore, evidence on chemopreventive treatments, including aspirin, antidiabetic treatments and statins is summarised. The role of adjuvant therapies for tertiary prevention of HCC is briefly reviewed. (C) 2021 The Author(s). Published by Elsevier B.V. on behalf of European Association for the Study of the Liver. C1 [Lange, Naomi F.; Radu, Pompilia; Dufour, Jean-Francois] Inselspital Bern, Univ Clin Visceral Surg & Med, Bern, Switzerland. [Lange, Naomi F.] Univ Bern, Grad Sch Hlth Sci, Bern, Switzerland. C3 University of Bern; University Hospital of Bern; University of Bern RP Lange, NF (通讯作者)，MEM F708,Murtenstr 35, CH-3008 Bern, Switzerland. EM naomi.lange@insel.ch RI Dufour, Jean/AAL-9866-2020; Lange, Naomi F/JCO-3344-2023 OI Lange, Naomi F/0000-0002-9519-4949 FU Swiss Liver Foundation; Gottfried and Julia Bangerter-Rhyner Foundation; Swiss Academy of Medical Sciences (SAMS) FX NL would like to thank the Swiss Liver Foundation, and the Gottfried and Julia Bangerter-Rhyner Foundation and Swiss Academy of Medical Sciences (SAMS) for supporting her work. 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Hepatol. PD NOV PY 2021 VL 75 IS 5 BP 1217 EP 1227 DI 10.1016/j.jhep.2021.07.025 EA OCT 2021 PG 11 WC Gastroenterology & Hepatology WE Science Citation Index Expanded (SCI-EXPANDED) SC Gastroenterology & Hepatology GA WK4ZK UT WOS:000709735200003 PM 34339764 OA Bronze DA 2026-02-02 ER PT J AU Tauil, RB Golono, PT de Lima, EP Goulart, RD Guiguer, EL Bechara, MD Nicolau, CCT Yanaguizawa, JL Jr Fiorini, AMR Méndez-Sánchez, N Abenavoli, L Direito, R Valente, VE Laurindo, LF Barbalho, SM AF Tauil, Raissa Bulaty Golono, Paula Takano de Lima, Enzo Pereira Goulart, Ricardo de Alvares Guiguer, Elen Landgraf Bechara, Marcelo Dib Nicolau, Claudia C. T. Yanaguizawa, Jose Luiz Fiorini, Adriana M. R. Mendez-Sanchez, Nahum Abenavoli, Ludovico Direito, Rosa Valente, Vitor Engracia Laurindo, Lucas Fornari Barbalho, Sandra Maria TI Metabolic-Associated Fatty Liver Disease: The Influence of Oxidative Stress, Inflammation, Mitochondrial Dysfunctions, and the Role of Polyphenols SO PHARMACEUTICALS LA English DT Review DE metabolic-associated fatty liver disease; MAFLD; liver disease; inflammation; oxidative stress; mitochondrial dysfunction; polyphenols ID IMPROVES INSULIN-RESISTANCE; DE-NOVO LIPOGENESIS; ADIPOSE-TISSUE; VITAMIN-E; RESVERATROL SUPPLEMENTATION; MOLECULAR-MECHANISMS; MEDITERRANEAN DIET; LIPID-METABOLISM; BLOOD-PRESSURE; DOUBLE-BLIND AB Metabolic-Associated Fatty Liver Disease (MAFLD) is a clinical-pathological scenario that occurs due to the accumulation of triglycerides in hepatocytes which is considered a significant cause of liver conditions and contributes to an increased risk of death worldwide. Even though the possible causes of MAFLD can involve the interaction of genetics, hormones, and nutrition, lifestyle (diet and sedentary lifestyle) is the most influential factor in developing this condition. Polyphenols comprise many natural chemical compounds that can be helpful in managing metabolic diseases. Therefore, the aim of this review was to investigate the impact of oxidative stress, inflammation, mitochondrial dysfunction, and the role of polyphenols in managing MAFLD. Some polyphenols can reverse part of the liver damage related to inflammation, oxidative stress, or mitochondrial dysfunction, and among them are anthocyanin, baicalin, catechin, curcumin, chlorogenic acid, didymin, epigallocatechin-3-gallate, luteolin, mangiferin, puerarin, punicalagin, resveratrol, and silymarin. These compounds have actions in reducing plasma liver enzymes, body mass index, waist circumference, adipose visceral indices, lipids, glycated hemoglobin, insulin resistance, and the HOMA index. They also reduce nuclear factor-KB (NF-KB), interleukin (IL)-1 beta, IL-6, tumor necrosis factor-alpha (TNF-alpha), blood pressure, liver fat content, steatosis index, and fibrosis. On the other hand, they can improve HDL-c, adiponectin levels, and fibrogenesis markers. These results show that polyphenols are promising in the prevention and treatment of MAFLD. C1 [Tauil, Raissa Bulaty; Golono, Paula Takano; de Lima, Enzo Pereira; Guiguer, Elen Landgraf; Bechara, Marcelo Dib; Barbalho, Sandra Maria] Univ de Marilia UNIMAR, Sch Med, Dept Biochem & Pharmacol, BR-17525902 Marilia, SP, Brazil. [Goulart, Ricardo de Alvares; Guiguer, Elen Landgraf; Bechara, Marcelo Dib; Yanaguizawa, Jose Luiz; Barbalho, Sandra Maria] Univ Marilia UNIMAR, Postgrad Program Struct & Funct Interact Rehabil, Sch Med, BR-17525902 Marilia, SP, Brazil. [Guiguer, Elen Landgraf; Nicolau, Claudia C. T.; Fiorini, Adriana M. R.; Barbalho, Sandra Maria] Sch Food & Technol Marilia FATEC, Dept Biochem & Nutr, BR-17500000 Marilia, SP, Brazil. [Mendez-Sanchez, Nahum] Med Sur Clin Fdn, Liver Res Unit, Mexico City 14050, Mexico. [Mendez-Sanchez, Nahum] Univ Nacl Autonoma Mexico, Fac Med, Mexico City 04510, Mexico. [Abenavoli, Ludovico] Magna Graecia Univ Catanzaro, Dept Hlth Sci, Viale Europa, I-88100 Catanzaro, Italy. [Direito, Rosa] Univ Lisboa iMed ULisboa, Res Inst Med, Lab Syst Integrat Pharmacol Clin & Regulatory Sci, Ave Prof Gama Pinto, P-1649003 Lisbon, Portugal. [Valente, Vitor Engracia] Sao Paulo State Univ, Auton Nervous Syst Ctr, Sch Philosophy & Sci, BR-17525902 Marilia, SP, Brazil. [Laurindo, Lucas Fornari] Fac Med Marilia FAMEMA, Sch Med, Dept Biochem & Pharmacol, BR-17519030 Marilia, SP, Brazil. [Barbalho, Sandra Maria] Univ Marilia UNIMAR, UNIMAR Char Hosp, Res Coordinat, BR-17525902 Marilia, SP, Brazil. C3 Universidade de Marilia; Universidad Nacional Autonoma de Mexico; Magna Graecia University of Catanzaro; Universidade Estadual Paulista; Faculdade de Medicina de Marilia; Universidade de Marilia RP Barbalho, SM (通讯作者)，Univ de Marilia UNIMAR, Sch Med, Dept Biochem & Pharmacol, BR-17525902 Marilia, SP, Brazil.; Barbalho, SM (通讯作者)，Univ Marilia UNIMAR, Postgrad Program Struct & Funct Interact Rehabil, Sch Med, BR-17525902 Marilia, SP, Brazil.; Barbalho, SM (通讯作者)，Sch Food & Technol Marilia FATEC, Dept Biochem & Nutr, BR-17500000 Marilia, SP, Brazil.; Barbalho, SM (通讯作者)，Univ Marilia UNIMAR, UNIMAR Char Hosp, Res Coordinat, BR-17525902 Marilia, SP, Brazil. 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TC 27 Z9 31 U1 8 U2 48 PU MDPI PI BASEL PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND EI 1424-8247 J9 PHARMACEUTICALS-BASE JI Pharmaceuticals PD OCT PY 2024 VL 17 IS 10 AR 1354 DI 10.3390/ph17101354 PG 45 WC Chemistry, Medicinal; Pharmacology & Pharmacy WE Science Citation Index Expanded (SCI-EXPANDED) SC Pharmacology & Pharmacy GA K1Y0X UT WOS:001341894300001 PM 39458995 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Aller, R Izaola, O de la Fuente, B de Luis, D AF Aller, Rocio Izaola, Olatz de la Fuente, Beatriz de Luis, Daniel TI Mediterranean diet is associated with liver histology in patients with non alcoholic fatty liver disease SO NUTRICION HOSPITALARIA LA English DT Article DE Insulin resistance; Mediterranean diet; Non-alcoholic fatty liver disease; Liver biopsy ID INSULIN-RESISTANCE; NONALCOHOLIC STEATOHEPATITIS; HEPATIC STEATOSIS; HYPOCALORIC DIETS; OBESE-PATIENTS; FIBROSIS; TRANSAMINASES; ADIPONECTIN; CONSUMPTION; REDUCTION AB Background: clinical data on impact of the Mediterranean diet on the the stage of non alcoholic fatty liver disease are limited and these studies have heterogeneous designs. Aim: we decide to explore any potential associations between adherence to the Mediterranean diet and histological characteristics of patients with NAFLD. Methods: a sample of 82 patients was analyzed in a cross sectional study. To evaluate the level of adherence to the Mediterranean dietary pattern the 14-Item Mediterranean Diet Assessment Tool was used. Results: thirty five patients (42.7%) had a low grade of steatosis (grade 1 of classification) and 47 patients (57.3%) had a high grade of steatosis (grade 2 and 3). Fifty-six patients (68.3%) had liver steatohepatitis and forty-two patients (51.2%) had liver fibrosis. In the logistic regresion analysis, one unit of the 14-Item Mediterranean Diet Assessment Tool was associated with a lower likehood of having steatohepatitis odds ratio 0.43 (CI:95 %: 0.29-0.64) and steatosis 0.42 (CI:95 % : 0.26-0.70). Secondly, one unit of HOMA-IR was associated with higher likehood of having steatosis odds ratio 2.01 (CI:95 % : 1.08-3.71) and liver fibrosis 1.38 (CI:95 % : 1.10-1.80). Conclusions: greater adherence to the Mediterranean diet was associated with lower likelihood of high grade of steatosis and presence of steatohepatitis. C1 [Aller, Rocio; Izaola, Olatz; de la Fuente, Beatriz; de Luis, Daniel] Univ Valladolid, Sch Med, Ctr Invest Endocrinol & Nutr, Hosp Clin Univ, Valladolid 47130, Spain. [Aller, Rocio] Univ Valladolid, Hosp Clin Univ, Dept Gastroenterol, Valladolid 47130, Spain. [Izaola, Olatz; de Luis, Daniel] Univ Valladolid, Hosp Clin Univ, Dept Endocrinol & Nutr, Valladolid 47130, Spain. C3 Universidad de Valladolid; Universidad de Valladolid; Universidad de Valladolid RP de Luis, D (通讯作者)，Univ Valladolid, Sch Med, Ctr Invest Endocrinol & Nutr, C Perales 16, Valladolid 47130, Spain. 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Hosp. PD DEC PY 2015 VL 32 IS 6 BP 2518 EP 2524 DI 10.3305/nh.2015.32.6.10074 PG 7 WC Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Nutrition & Dietetics GA CZ9KX UT WOS:000367417600020 PM 26667698 DA 2026-02-02 ER PT J AU Priore, P Cavallo, A Gnoni, A Damiano, F Gnoni, GV Siculella, L AF Priore, Paola Cavallo, Alessandro Gnoni, Antonio Damiano, Fabrizio Gnoni, Gabriele V. Siculella, Luisa TI Modulation of Hepatic Lipid Metabolism by Olive Oil and its Phenols in Nonalcoholic Fatty Liver Disease SO IUBMB LIFE LA English DT Review DE lipogenesis; lipid metabolism; mitochondria; non-alcoholic fatty liver disease; oleic acid; olive oil; phenols ID TRICARBOXYLATE CARRIER; RAT-LIVER; OLEIC-ACID; MITOCHONDRIAL DYSFUNCTION; MICROARRAY ANALYSIS; MEDITERRANEAN DIET; INSULIN-RESISTANCE; LIPOGENESIS; OLEUROPEIN; STEATOHEPATITIS AB Nonalcoholic fatty liver disease (NAFLD) represents the most common chronic liver disease in western countries, being considered the hepatic manifestation of metabolic syndrome. Cumulative lines of evidence suggest that olive oil, used as primary source of fat by Mediterranean populations, may play a key role in the observed health benefits on NAFLD. In this review, we summarize the state of the art of the knowledge on the protective role of both major and minor components of olive oil on lipid metabolism during NAFLD. In particular, the biochemical mechanisms responsible for the increase or decrease in hepatic lipid content are critically analyzed, taking into account that several studies have often provided different and/or conflicting results in animal models fed on olive oil-enriched diet. In addition, new findings that highlight the hypolipidemic and the antisteatotic actions of olive oil phenols are presented. As mitochondrial dysfunction plays a key role in the pathogenesis of NAFLD, the targeting of these organelles with olive oil phenols as a powerful therapeutic approach is also discussed. (c) 2015 IUBMB Life, 67(1):9-17, 2015 C1 [Priore, Paola; Cavallo, Alessandro; Damiano, Fabrizio; Gnoni, Gabriele V.; Siculella, Luisa] Univ Salento, Dept Biol & Environm Sci & Technol, Lab Biochem & Mol Biol, Lecce, Italy. [Gnoni, Antonio] Univ Bari Aldo Moro, Dept Basical Med Sci Neurosci & Sensory Organs, Bari, Italy. C3 University of Salento; Universita degli Studi di Bari Aldo Moro RP Siculella, L (通讯作者)，Univ Salento, Lab Biochim & Biol Mol, Dipartimento Sci & Tecnol Biol & Ambientali, Via Prov Le Lecce Monteroni, I-73100 Lecce, Italy. EM luisa.siculella@unisalento.it RI ; Damiano, Fabrizio/AAF-9594-2020; Gnoni, Antonio/C-8078-2014 OI Siculella, Luisa/0000-0002-6890-3674; Damiano, Fabrizio/0000-0001-7828-9519; Gnoni, Antonio/0000-0001-5071-611X FU Apulia Region (Italy) [PON 01_01958 PIVOLIO] FX This study was supported by Grants from Apulia Region (Italy), PON 01_01958 PIVOLIO. 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V268, P5734, DOI 10.1046/j.0014-2956.2001.02508.x Zhu L, 2010, J NUTR BIOCHEM, V21, P1089, DOI 10.1016/j.jnutbio.2009.09.006 NR 69 TC 52 Z9 54 U1 1 U2 20 PU WILEY PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1521-6543 EI 1521-6551 J9 IUBMB LIFE JI IUBMB Life PD JAN PY 2015 VL 67 IS 1 BP 9 EP 17 DI 10.1002/iub.1340 PG 9 WC Biochemistry & Molecular Biology; Cell Biology WE Science Citation Index Expanded (SCI-EXPANDED) SC Biochemistry & Molecular Biology; Cell Biology GA CE4BU UT WOS:000351776600003 PM 25631376 OA Green Submitted, Bronze DA 2026-02-02 ER PT J AU Castillo, V Figueroa, F González-Pizarro, K Jopia, P Ibacache-Quiroga, C AF Castillo, Valentina Figueroa, Fernanda Gonzalez-Pizarro, Karoll Jopia, Paz Ibacache-Quiroga, Claudia TI Probiotics and Prebiotics as a Strategy for Non-Alcoholic Fatty Liver Disease, a Narrative Review SO FOODS LA English DT Review DE non-alcoholic fatty liver disease (NAFLD); gut microbiota; prebiotics; probiotics; synbiotics ID GUT MICROBIOTA; INSULIN-RESISTANCE; AMERICAN ASSOCIATION; MEDITERRANEAN DIET; HEPATIC STEATOSIS; RANDOMIZED-TRIAL; POTENTIAL ROLE; DOUBLE-BLIND; VITAMIN-E; HEALTH AB Non-alcoholic fatty liver disease (NAFLD) is a chronic non-communicable disease, with a prevalence of 25% worldwide. This pathology is a multifactorial illness, and is associated with different risks factors, including hypertension, hyperglycemia, dyslipidemia, and obesity. Beside these predisposing features, NAFLD has been related to changes in the microbiota, which favor the disease progression. In this context, the modulation of the gut microbiota has emerged as a new therapeutic target for the prophylaxis and treatment of NAFLD. This review describes the changes in the gut microbiota associated with NAFLD and the effect of probiotics, prebiotics, and synbiotics on the gut microbiota, liver damage, anthropometric parameters, blood lipids, inflammation markers and insulin resistance in these patients. C1 [Castillo, Valentina; Figueroa, Fernanda; Gonzalez-Pizarro, Karoll; Ibacache-Quiroga, Claudia] Univ Valparaiso, Fac Farm, Escuela Nutr & Dietet, Valparaiso 2360102, Chile. [Gonzalez-Pizarro, Karoll; Jopia, Paz; Ibacache-Quiroga, Claudia] Univ Valparaiso, Ctr Microbioinnovac, Valparaiso 2360102, Chile. C3 Universidad de Valparaiso; Universidad de Valparaiso RP Ibacache-Quiroga, C (通讯作者)，Univ Valparaiso, Fac Farm, Escuela Nutr & Dietet, Valparaiso 2360102, Chile.; Ibacache-Quiroga, C (通讯作者)，Univ Valparaiso, Ctr Microbioinnovac, Valparaiso 2360102, Chile. EM valentina.castillo@alumnos.uv.cl; fernanda.figueroaa@alumnos.uv.cl; karoll.gonzalez@uv.cl; paz.jopia@uv.cl; claudia.ibacache@uv.cl RI Castillo, Valentina/JGE-0336-2023; Jopia-Contreras, Paz/HPE-3012-2023; Ibacache, Claudia/HZI-1219-2023 OI Jopia-Contreras, Paz/0000-0003-0051-9809; Ibacache, Claudia/0000-0002-1978-6109; González-Pizarro, Karoll/0000-0002-3592-6028 FU UNIVERSIDAD DE VALPARAISO [DIUV-CIDI 4/2016, PAI79170114] FX This research was funded by UNIVERSIDAD DE VALPARAISO grant number DIUV-CIDI 4/2016, and by ANID grant number PAI79170114. 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V8, P4539, DOI 10.1039/c7fo01108c Younossi ZM, 2016, HEPATOLOGY, V64, P73, DOI 10.1002/hep.28431 Zhu LX, 2015, PEDIATR RES, V77, P245, DOI 10.1038/pr.2014.157 Zhu LX, 2013, HEPATOLOGY, V57, P601, DOI 10.1002/hep.26093 NR 118 TC 30 Z9 33 U1 1 U2 24 PU MDPI PI BASEL PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND EI 2304-8158 J9 FOODS JI Foods PD AUG PY 2021 VL 10 IS 8 AR 1719 DI 10.3390/foods10081719 PG 18 WC Food Science & Technology WE Science Citation Index Expanded (SCI-EXPANDED) SC Food Science & Technology GA UI3UB UT WOS:000690535500001 PM 34441497 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Assy, N Nassar, F Nasser, G Grosovski, M AF Assy, Nimer Nassar, Faris Nasser, Gattas Grosovski, Maria TI Olive oil consumption and non-alcoholic fatty liver disease SO WORLD JOURNAL OF GASTROENTEROLOGY LA English DT Review DE Liver steatosis; Fatty liver; Olive oil; Fatty acids; Monounsaturated; Non-alcoholic steatohepatitis; Lipids; Oleic acid; Non-alcoholic fatty liver disease ID HIGH-MONOUNSATURATED-FAT; INSULIN-RESISTANCE; OLEIC-ACID; RICH DIET; POSTPRANDIAL LIPEMIA; MEDITERRANEAN DIET; BLOOD-PRESSURE; DIABETES-MELLITUS; HEPATIC STEATOSIS; HIGH-CARBOHYDRATE AB The clinical implications of non-alcoholic fatty liver diseases (NAFLD) derive from their potential to progress to fibrosis and cirrhosis. Inappropriate dietary fat intake, excessive intake of soft drinks, insulin resistance and increased oxidative stress results in increased free fatty acid delivery to the liver and increased hepatic triglyceride (TG) accumulation. An olive oil-rich diet decreases accumulation of TGs in the liver, improves postprandial TGs, glucose and glucagonlike peptide-1 responses in insulin-resistant subjects, and upregulates glucose transporter-2 expression in the liver. The principal mechanisms include: decreased nuclear factor-kappa B activation, decreased low-density lipoprotein oxidation, and improved insulin resistance by reduced production of inflammatory cytokines (tumor necrosis factor, interleukin-6) and improvement of jun N-terminal kinase-mediated phosphorylation of insulin receptor substrate-1. The beneficial effect of the Mediterranean diet is derived from monounsaturated fatty acids, mainly from olive oil. In this review, we describe the dietary sources of the monounsaturated fatty acids, the composition of olive oil, dietary fats and their relationship to insulin resistance and postprandial lipid and glucose responses in non-alcoholic steatohepatitis, clinical and experimental studies that assess the relationship between olive oil and NAFLD, and the mechanism by which olive oil ameliorates fatty liver, and we discuss future perspectives. (C) 2009 The WJG Press and Baishideng. All rights reserved. C1 [Assy, Nimer] Ziv Med Ctr, Liver Unit, IL-13100 Safed, Israel. [Assy, Nimer] Technion Israel Inst Technol, Fac Med, IL-32000 Haifa, Israel. [Nassar, Faris; Nasser, Gattas] Western Galilee Hosp, Dept Med, IL-22356 Nahariyya, Israel. [Grosovski, Maria] Ort Braude Coll, Dept Biotechnol, IL-20100 Karmiel, Israel. C3 Ziv Medical Center; Technion Israel Institute of Technology; Rappaport Faculty of Medicine; Western Galilee Hospital; Braude Academic College of Engineering RP Assy, N (通讯作者)，Ziv Med Ctr, Liver Unit, IL-13100 Safed, Israel. 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Gastroenterol. PD APR 21 PY 2009 VL 15 IS 15 BP 1809 EP 1815 DI 10.3748/wjg.15.1809 PG 7 WC Gastroenterology & Hepatology WE Science Citation Index Expanded (SCI-EXPANDED) SC Gastroenterology & Hepatology GA 436AS UT WOS:000265385600004 PM 19370776 OA Green Submitted, hybrid DA 2026-02-02 ER PT J AU Brunetto, MR Salvati, A Petralli, G Bonino, F AF Brunetto, Maurizia R. Salvati, Antonio Petralli, Giovanni Bonino, Ferruccio TI Nutritional intervention in the management of non-alcoholic fatty liver disease SO BEST PRACTICE & RESEARCH CLINICAL GASTROENTEROLOGY LA English DT Article ID CLINICAL-PRACTICE; GUT MICROBIOTA; NAFLD; DIET; ASSOCIATION; CONSUMPTION; SUGAR AB Lifestyle modification is the primary intervention to control NAFLD progression, but despite evidence-based effectiveness it is difficult to distinguish the benefits of nutrition from physical activity and the optimal diet composition is not established. Macronutrients as saturated fatty acids, sugars and animal proteins are harmful in NAFLD and the Mediterranean Diet reducing sugar, red meat and refined carbohydrates and increasing unsaturated-fatty-acids was reported to be beneficial. However one size cannot fit all since NAFLD is a multifaceted syndrome encompassing many diseases of unknown etiologies, different clinical severity and outcomes. Studies of the intestinal metagenome, provided new insights into the physio-pathological interplay between intestinal microbiota and NAFLD. How much the microbiota heterogeneity can influence response to diet remains unknown. New knowledge indicates that AI guided personalized nutrition based on clinic-pathologic and genetic data combined with pre/post nutritional intervention gut metagenomics/metabolomics will be part of the future management of NAFLD. C1 [Brunetto, Maurizia R.; Salvati, Antonio; Bonino, Ferruccio] Univ Hosp Pisa, Reference Ctr Tuscany Reg Chron Liver Dis & Canc, Hepatol Unit, Via Paradisa 2, I-56124 Pisa, Italy. [Brunetto, Maurizia R.; Bonino, Ferruccio] Univ Pisa, Dept Clin & Expt Med, Pisa, Italy. [Brunetto, Maurizia R.] CNR, Inst Biostruct & Bioimaging, Via De Amicis 95, I-80145 Naples, Italy. [Petralli, Giovanni] Univ Pisa, Dept Surg Med & Mol & Crit Area Pathol, Pisa, Italy. C3 University of Pisa; Azienda Ospedaliero Universitaria Pisana; University of Pisa; Consiglio Nazionale delle Ricerche (CNR); Istituto di Biostrutture e Bioimmagini (IBB-CNR); University of Pisa RP Brunetto, MR (通讯作者)，Univ Hosp Pisa, Reference Ctr Tuscany Reg Chron Liver Dis & Canc, Hepatol Unit, Via Paradisa 2, I-56124 Pisa, Italy. 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Res. Clin. Gastroenterol. PD FEB-MAR PY 2023 VL 62-63 AR 101830 DI 10.1016/j.bpg.2023.101830 EA APR 2023 PG 7 WC Gastroenterology & Hepatology WE Science Citation Index Expanded (SCI-EXPANDED) SC Gastroenterology & Hepatology GA G3WY2 UT WOS:000988510800001 PM 37094914 OA hybrid DA 2026-02-02 ER PT J AU Mascaró, CM Bouzas, C Montemayor, S García, S Mateos, D Casares, M Gómez, C Ugarriza, L Borràs, PA Martínez, JA Tur, JA AF Mascaro, Catalina M. Bouzas, Cristina Montemayor, Sofia Garcia, Silvia Mateos, David Casares, Miguel Gomez, Cristina Ugarriza, Lucia Borras, Pere-Antoni Martinez, J. Alfredo Tur, Josep A. TI Impact of Physical Activity Differences Due to COVID-19 Pandemic Lockdown on Non-Alcoholic Fatty Liver Parameters in Adults with Metabolic Syndrome SO NUTRIENTS LA English DT Article DE Mediterranean diet; physical activity; Mediterranean lifestyle; non-alcoholic fatty liver disease; metabolic syndrome; fitness; COVID-19 lockdown ID ACTIVITY QUESTIONNAIRE; LIFE-STYLE; DISEASE; ASSOCIATION; VALIDATION; DIAGNOSIS; NAFLD; DIET AB Background: A Mediterranean lifestyle with a Mediterranean diet and regular physical activity (PA) improves metabolic syndrome (MetS) characteristics and non-alcoholic fatty liver disease (NAFLD). The COVID-19 pandemic stopped healthy habits and increased NAFLD progression. Objectives: To assess how PA differences due to COVID-19 lockdown affected NAFLD parameters in adults with MetS. Design: Longitudinal 2-year analysis of data obtained between COVID-19 pre- and post-lockdown in a parallel-group randomized trial (n = 57, aged 40-60 years old, with MetS and NAFLD). Methods: NAFLD status and related parameters were assessed by magnetic resonance imaging (MRI), blood collection analysis and related indexes. PA and fitness status were assessed by an Alpha-Fit test battery, accelerometers, validated Minnesota questionnaire and functional fitness score. During lockdown, study personnel telephoned patients to motivate them. Participants were grouped according to PA levels. Results: The low PA group improved its fitness score tests (0.2) after lockdown more than the medium PA group, and it decreased its sedentary activity (-48.7 min/day), increased light (20.9 min/day) and moderate (32.3 min/day) PA intensities and improved sleep efficiency (0.6%) in comparison with the medium and high PA groups. The high PA group increased its steps per day more than the other groups. The low PA group was the only group that decreased its gamma glutamyl transferase (GGT) levels (-17.0 U/L). All groups increased their fatty liver index (FLI) after lockdown, but the medium PA group increased its FLI more than the low PA group. Participants in the high PA group decreased their HDL-cholesterol levels more than participants in the medium PA group (-0.4 mg/dL). Conclusions: Stopping regular PA together with an unhealthy lifestyle leads to a worsening of MetS and NAFLD. COVID-19 lockdown induced a decrease in PA in more active people, but inactive people increased their PA levels. Motivation seemed to be very important during lockdown. C1 [Mascaro, Catalina M.; Bouzas, Cristina; Montemayor, Sofia; Garcia, Silvia; Mateos, David; Gomez, Cristina; Ugarriza, Lucia; Tur, Josep A.] Univ Balearic Isl IUNICS, Res Grp Community Nutr & Oxidat Stress, Palma De Mallorca 07122, Spain. [Mascaro, Catalina M.; Bouzas, Cristina; Montemayor, Sofia; Garcia, Silvia; Mateos, David; Ugarriza, Lucia; Tur, Josep A.] Hlth Inst Balearic Isl IDISBA, Palma De Mallorca 07120, Spain. [Bouzas, Cristina; Tur, Josep A.] Inst Salud Carlos III ISCIII, CIBEROBN Physiopathol Obes & Nutr CB12 03 30038, Madrid 28029, Spain. [Casares, Miguel] Red Asistencial Juaneda, Radiodiag Serv, Palma De Mallorca 07011, Spain. [Gomez, Cristina] Univ Hosp Son Espases, Clin Anal Serv, Palma De Mallorca 07120, Spain. [Ugarriza, Lucia] Camp Redo Primary Hlth Care Ctr, Palma De Mallorca 07010, Spain. [Borras, Pere-Antoni] Univ Balearic Isl, Dept Pedag & Specif Didact, Area Phys Educ & Sports, Palma De Mallorca 07122, Spain. [Martinez, J. Alfredo] CEI UAM CSIC, IMDEA Food, Cardiomet Precis Nutr Program, Madrid 28049, Spain. [Martinez, J. Alfredo] Univ Navarra, Dept Nutr Food Sci & Physiol, Pamplona 31008, Spain. C3 CIBER - Centro de Investigacion Biomedica en Red; CIBEROBN; Hospital Universitari Son Espases; Universitat de les Illes Balears; Consejo Superior de Investigaciones Cientificas (CSIC); IMDEA Food Institute; University of Navarra RP Tur, JA (通讯作者)，Univ Balearic Isl IUNICS, Res Grp Community Nutr & Oxidat Stress, Palma De Mallorca 07122, Spain.; Tur, JA (通讯作者)，Hlth Inst Balearic Isl IDISBA, Palma De Mallorca 07120, Spain.; Tur, JA (通讯作者)，Inst Salud Carlos III ISCIII, CIBEROBN Physiopathol Obes & Nutr CB12 03 30038, Madrid 28029, Spain. EM c.mascaro@uib.es; cristina.bouzas@uib.es; sofiamf16@gmail.com; silvia.garcia@uib.es; davidfrom13@gmail.com; casaresmiguel@gmail.com; cristina.gomez@ssib.es; luciaugarriza@gmail.com; pa-borras@uib.es; jalfredo.martinez@imdea.org; pep.tur@uib.es RI ; BORRAS, PERE A/H-2403-2013; Tur, Josep/AAE-5748-2020; Bouzas, Cristina/AAE-2069-2019; Martínez, J./K-8709-2014 OI Montemayor, Sofía/0000-0001-7833-2118; BORRAS, PERE A/0000-0001-6793-7592; Tur, Josep/0000-0002-6940-0761; Bouzas Velasco, Cristina/0000-0002-1407-8461; GOMEZ COBO, CRISTINA/0000-0002-9776-4730; FU Fundacio La Marato TV3 (Spain) project [201630.10]; Instituto de Salud Carlos III through the CIBEROBN [CB12/03/30038]; European Regional Development Fund [CB12/03/30038]; Spanish Ministry of Education; FOLIUM; PRIMUS; SYNERGIA; LIBERI FX Fundacio La Marato TV3 (Spain) project ref. 201630.10. Instituto de Salud Carlos III through the CIBEROBN CB12/03/30038, and Proyecto Intramural CIBER OBN18PI03, which are co-funded by the European Regional Development Fund. Other funding received: IDISBA Grants (FOLIUM, PRIMUS, SYNERGIA, and LIBERI). Catalina M. Mascaro received an FPU PhD Grant from the Spanish Ministry of Education. The funding sponsors had no role in the design of the study, in the collection, analyses, or interpretation of the data; in the writing of the manuscript, or in the decision to publish the results. 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Ravi, Sujan Loomba, Rohit Gray, Meagan E. TI Evidence-based clinical advice for nutrition and dietary weight loss strategies for the management of NAFLD and NASH SO CLINICAL AND MOLECULAR HEPATOLOGY LA English DT Review DE Diet; Vegetarian; Diet; Healthy; Nonalcoholic fatty liver disease; Diet ID FATTY LIVER-DISEASE; RANDOMIZED CONTROLLED-TRIAL; MODEST ALCOHOL-CONSUMPTION; PROCESSED MEAT CONSUMPTION; NONALCOHOLIC STEATOHEPATITIS; HEPATIC STEATOSIS; RED MEAT; FRUCTOSE CONSUMPTION; INSULIN SENSITIVITY; LIPID-METABOLISM AB Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease worldwide and affects approximately one third of adults in the United States. The disease is becoming a global epidemic as a result of the rising rates of obesity and metabolic disease. Emerging data suggest weight loss of >= 10% overall body weight is beneficial in resolving steatosis and reversing fibrosis. Prospective trials comparing various diets are limited by lack of sufficient power as well as pre- and post-treatment histopathology, and therefore no specific diet is recommended at this time. In this narrative review we examine the pathophysiology behind specific macronutrient components that can either promote or reverse NAFLD to help inform more specific dietary recommendations. Overall, the data supports reducing saturated fat, refined carbohydrates, and red and processed meats in the diet, and increasing the consumption of plant-based foods. Diets that incorporate these recommendations include plant-based diets such as the Dietary Approaches to Stop Hypertension, Mediterranean, vegetarian, and vegan diets. C1 [Hydes, Theresa J.; Ravi, Sujan; Gray, Meagan E.] Univ Alabama Birmingham, Div Gastroenterol & Hepatol, BDB 395A,1720 2nd Ave S, Birmingham, AL 35294 USA. [Loomba, Rohit] Univ Calif San Diego, Div Gastroenterol, La Jolla, CA 92093 USA. C3 University of Alabama System; University of Alabama Birmingham; University of California System; University of California San Diego RP Gray, ME (通讯作者)，Univ Alabama Birmingham, Div Gastroenterol & Hepatol, BDB 395A,1720 2nd Ave S, Birmingham, AL 35294 USA. EM grayme@uab.edu RI Loomba, Rohit/AAE-7831-2019; HYDES, THERESA/H-1060-2019 OI Loomba, Rohit/0000-0002-4845-9991; HYDES, THERESA/0000-0002-7768-6886 FU NIDDK [R01DK108353, R01DK106419, P30DK120515]; NIEHS [5P42ES010337]; NCATS [5UL1TR001442]; DOD PRCRP [CA170674P2]; Allergan; Boehringer-Ingelheim; Bristol-Myers Squibb; Cirius; Eli Lilly and Company; Galectin Therapeutics; Galmed Pharmaceuticals; GE; Genfit; Gilead; Intercept; Grail; Janssen; Madrigal Pharmaceuticals; Merck; NGM Biopharmaceuticals; NuSirt; Pfizer; pH Pharma; Prometheus; Siemens; National Center for Advancing Translational Sciences [UL1TR001442] Funding Source: NIH RePORTER; National Institute of Diabetes and Digestive and Kidney Diseases [P30DK120515] Funding Source: NIH RePORTER; National Institute of Environmental Health Sciences [P42ES010337] Funding Source: NIH RePORTER; CDMRP [CA170674P2, 1100671] Funding Source: Federal RePORTER FX No grant or financial support of any of the authors is related to this work. MG receives funding support from NIDDK (R01DK108353). RL receives funding support from NIEHS (5P42ES010337), NCATS (5UL1TR001442), NIDDK (R01DK106419, P30DK120515), and DOD PRCRP (CA170674P2). Potential competing interests: MG serves as an advisory board member for Intercept. RL serves as a consultant or advisory board member for Arrowhead Pharmaceuticals, AstraZeneca, Bird Rock Bio, Boehringer Ingelheim, BristolMyer Squibb, Celgene, Cirius, CohBar, Conatus, Eli Lilly, Galmed, Gemphire, Gilead, Glympse bio, GNI, GRI Bio, Intercept, Ionis, Janssen Inc., Merck, Metacrine, Inc., NGM Biopharmaceuticals, Novartis, Novo Nordisk, Pfizer, Prometheus, Sanofi, Siemens, and Viking Therapeutics. In addition, his institution has received grant support from Allergan, Boehringer-Ingelheim, Bristol-Myers Squibb, Cirius, Eli Lilly and Company, Galectin Therapeutics, Galmed Pharmaceuticals, GE, Genfit, Gilead, Intercept, Grail, Janssen, Madrigal Pharmaceuticals, Merck, NGM Biopharmaceuticals, NuSirt, Pfizer, pH Pharma, Prometheus, and Siemens. He is also co-founder of Liponexus, Inc. 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Mol. Hepatol. PD OCT PY 2020 VL 26 IS 4 BP 383 EP 400 DI 10.3350/cmh.2020.0067 PG 18 WC Gastroenterology & Hepatology WE Science Citation Index Expanded (SCI-EXPANDED) SC Gastroenterology & Hepatology GA OE4OA UT WOS:000580510600001 PM 32674529 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Gelli, C Tarocchi, M Abenavoli, L Di Renzo, L Galli, A De Lorenzo, A AF Gelli, Chiara Tarocchi, Mirko Abenavoli, Ludovico Di Renzo, Laura Galli, Andrea De Lorenzo, Antonino TI Effect of a counseling-supported treatment with the Mediterranean diet and physical activity on the severity of the non-alcoholic fatty liver disease SO WORLD JOURNAL OF GASTROENTEROLOGY LA English DT Article DE Non-alcoholic fatty liver disease; Non-alcoholic steatohepatitis; Mediterranean diet; Metabolic syndrome; Therapeutic approach; Counseling; Diet; Life-style ID BODY-MASS INDEX; METABOLIC SYNDROME; HEPATIC STEATOSIS; ADHERENCE; METAANALYSIS; EPIDEMIOLOGY; ASSOCIATION; PREVALENCE; MANAGEMENT; EXERCISE AB AIM To determine the clinical effectiveness of nutritional counseling on reduction of non-alcoholic fatty liver disease (NAFLD) severity, weight loss, metabolic and anthropometric indexes and liver enzymes. METHODS forty-six adults with NAFLD received a 6-mo clinical and a dietary intervention (based on Mediterranean diet) carried out respectively by a gastroenterologist and a nutritionist with counseling license. The counseling process consisted of monthly meeting (about 45 min each). The effect of the treatment was evaluated monitoring liver enzymes, metabolic parameters, cardiovascular risk indexes, NAFLD severity [assessed by ultrasound (US)] and related indexes. All parameters were assessed at baseline. Biochemistry was also assessed at mid-and end-interventions and US was repeated at end-intervention. RESULTS The percentage of patients with steatosis grade equal or higher than 2 was reduced from 93% to 48% and steatosis regressed in 9 patients (20%). At the end of the treatment the end-point concerning the weight (i.e., a 7% weight reduction or achievement/maintenance of normal weight) was accomplished by 25 out of 46 patients (i.e., 54.3%). As far as the liver enzymes is concerned, all three liver enzymes significantly decrease during the treatment the normalization was particularly evident for the ALT enzyme (altered values reduced from 67% down to 11%). Several parameters, i. e., BMI, waist circumference, waist-to-hip ratio, AST, ALT, GGT, HDL, serum glucose, Tot-Chol/HDL, LDL/HDL, TG/ HDL, AIP, HOMA, FLI, Kotronen index, VAI, NAFLD liver fat score and LAP, showed a significant improvement (P < 0.01) between baseline and end-treatment. CONCLUSION Outcomes of this study further strengthen the hypothesis that MedDiet and more active lifestyle can be considered a safe therapeutic approach for reducing risk and severity of NAFLD and related disease states. The proposed approach may be proposed as a valid and recommended approach for improving the clinical profile of NAFLD patients. C1 [Gelli, Chiara; Di Renzo, Laura; De Lorenzo, Antonino] Univ Roma Tor Vergata, Dept Biomed & Prevent, Div Clin Nutr & Nutrigenom, I-0133 Rome, Italy. [Gelli, Chiara; Tarocchi, Mirko; Galli, Andrea] Univ Florence, Dept Expt & Clin Biomed Sci, Viale Morgagni 50, I-50134 Florence, Italy. [Abenavoli, Ludovico] Magna Graecia Univ Catanzaro, Dept Hlth Sci, Campus Germaneto, I-88100 Catanzaro, Italy. C3 University of Rome Tor Vergata; University of Florence; Magna Graecia University of Catanzaro RP Tarocchi, M (通讯作者)，Univ Florence, Dept Expt & Clin Biomed Sci, Viale Morgagni 50, I-50134 Florence, Italy. EM mirko.tarocchi@unifi.it RI Abenavoli, Ludovico/J-4394-2019; di renzo, laura/ACB-2003-2022; Galli, Anea/AAC-1623-2019 OI TAROCCHI, MIRKO/0000-0002-7767-5116; De Lorenzo, Antonino/0000-0001-6524-4493; di renzo, laura/0000-0001-8875-6723; Galli, Anea/0000-0001-5416-6290 FU Fondo per gli Investimenti della Ricerca di Base [RBAP10MY35_002]; Ente Cassa di Risparmio di Firenze; FiorGen ONLUS FX Supported by Fondo per gli Investimenti della Ricerca di Base, No. RBAP10MY35_002; Ente Cassa di Risparmio di Firenze; and FiorGen ONLUS to Galli A. CR Abenavoli L, 2016, WORLD J GASTROENTERO, V22, P7006, DOI 10.3748/wjg.v22.i31.7006 Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644 Altomare R, 2013, IRAN J PUBLIC HEALTH, V42, P449 Amato MC, 2010, DIABETES CARE, V33, P920, DOI 10.2337/dc09-1825 [Anonymous], 1997, JAMA-J AM MED ASSOC, V277, P925 Bach-Faig A, 2011, PUBLIC HEALTH NUTR, V14, P2274, DOI 10.1017/S1368980011002515 Bedogni G, 2006, BMC GASTROENTEROL, V6, DOI 10.1186/1471-230X-6-33 Centis E, 2013, J HEPATOL, V58, P771, DOI 10.1016/j.jhep.2012.11.031 Church TS, 2006, GASTROENTEROLOGY, V130, P2023, DOI 10.1053/j.gastro.2006.03.019 Dasarathy S, 2009, J HEPATOL, V51, P1061, DOI 10.1016/j.jhep.2009.09.001 Del Ben M, 2014, WORLD J GASTROENTERO, V20, P8341, DOI 10.3748/wjg.v20.i26.8341 European Association for the Study of the Liver (EASL), 2016, J Hepatol, V64, P1388, DOI 10.1016/j.jhep.2015.11.004 Franz MJ, 2007, J AM DIET ASSOC, V107, P1755, DOI 10.1016/j.jada.2007.07.017 Fraser A, 2008, DIABETOLOGIA, V51, P1616, DOI 10.1007/s00125-008-1049-1 George AS, 2009, HEPATOLOGY, V50, P68, DOI 10.1002/hep.22940 Ghaemi A, 2013, HEPAT MON, V13, DOI 10.5812/hepatmon.15227 Kaser S, 2010, INT J CLIN PRACT, V64, P968, DOI 10.1111/j.1742-1241.2009.02327.x Kastorini CM, 2011, J AM COLL CARDIOL, V57, P1299, DOI 10.1016/j.jacc.2010.09.073 Keating SE, 2012, J HEPATOL, V57, P157, DOI 10.1016/j.jhep.2012.02.023 Kontogianni MD, 2014, CLIN NUTR, V33, P678, DOI 10.1016/j.clnu.2013.08.014 Kotronen A, 2009, GASTROENTEROLOGY, V137, P865, DOI 10.1053/j.gastro.2009.06.005 Levene AP, 2012, HISTOPATHOLOGY, V61, P141, DOI 10.1111/j.1365-2559.2011.04145.x Lonardo A, 2015, DIGEST LIVER DIS, V47, P181, DOI 10.1016/j.dld.2014.09.020 Loria P, 2010, DIGEST LIVER DIS, V42, P272, DOI 10.1016/j.dld.2010.01.021 Mahady SE, 2016, METABOLISM, V65, P1172, DOI 10.1016/j.metabol.2015.10.032 Margariti A, 2013, J CLIN GASTROENTEROL, V47, P280, DOI 10.1097/MCG.0b013e31826be328 Martínez-González MA, 2008, BMJ-BRIT MED J, V336, P1348, DOI 10.1136/bmj.39561.501007.BE Montesi L, 2014, WORLD J GASTROENTERO, V20, P10128, DOI 10.3748/wjg.v20.i29.10128 Moore JB, 2010, P NUTR SOC, V69, P211, DOI 10.1017/S0029665110000030 Musso G, 2012, DIABETOLOGIA, V55, P885, DOI 10.1007/s00125-011-2446-4 Musso G, 2010, HEPATOLOGY, V52, P79, DOI 10.1002/hep.23623 Oliveira CP, 2016, J DIABETES RES, V2016, DOI 10.1155/2016/4597246 Panagiotakos DB, 2007, PREV MED, V44, P335, DOI 10.1016/j.ypmed.2006.12.009 Papamiltiadous ES, 2016, BMC GASTROENTEROL, V16, DOI 10.1186/s12876-016-0426-3 Perseghin G, 2007, DIABETES CARE, V30, P683, DOI 10.2337/dc06-2032 Ratziu V, 2010, J HEPATOL, V53, P372, DOI 10.1016/j.jhep.2010.04.008 Rector RS, 2008, WORLD J GASTROENTERO, V14, P185, DOI 10.3748/wjg.14.185 Ryan MC, 2013, J HEPATOL, V59, P138, DOI 10.1016/j.jhep.2013.02.012 Sofi F, 2014, WORLD J GASTROENTERO, V20, P7339, DOI 10.3748/wjg.v20.i23.7339 Sofi F, 2013, BIOFACTORS, V39, P335, DOI 10.1002/biof.1096 Sofi F, 2010, AM J CLIN NUTR, V92, P1189, DOI 10.3945/ajcn.2010.29673 Sumithran P, 2011, NEW ENGL J MED, V365, P1597, DOI 10.1056/NEJMoa1105816 Tarantino G, 2013, WORLD J GASTROENTERO, V19, P3375, DOI 10.3748/wjg.v19.i22.3375 Trichopoulou A, 2003, NEW ENGL J MED, V348, P2599, DOI 10.1056/NEJMoa025039 Tzima N, 2009, NUTR METAB, V6, DOI 10.1186/1743-7075-6-30 Wah-Kheong C, 2013, HEPATOL INT, V7, P65, DOI 10.1007/s12072-012-9384-1 Walle P, 2016, METABOLISM, V65, P655, DOI 10.1016/j.metabol.2016.01.011 Williams CD, 2011, GASTROENTEROLOGY, V140, P124, DOI 10.1053/j.gastro.2010.09.038 Zelber-Sagi S, 2011, WORLD J GASTROENTERO, V17, P3377, DOI 10.3748/wjg.v17.i29.3377 NR 49 TC 100 Z9 117 U1 1 U2 21 PU BAISHIDENG PUBLISHING GROUP INC PI PLEASANTON PA 7041 Koll Center Parkway, Suite 160, PLEASANTON, CA, UNITED STATES SN 1007-9327 EI 2219-2840 J9 WORLD J GASTROENTERO JI World J. Gastroenterol. PD MAY 7 PY 2017 VL 23 IS 17 BP 3150 EP 3162 DI 10.3748/wjg.v23.i17.3150 PG 13 WC Gastroenterology & Hepatology WE Science Citation Index Expanded (SCI-EXPANDED) SC Gastroenterology & Hepatology GA EU8WX UT WOS:000401320300016 PM 28533672 OA Green Submitted, Green Accepted, Bronze DA 2026-02-02 ER PT J AU Curci, R Bianco, A Franco, I Campanella, A Mirizzi, A Bonfiglio, C Sorino, P Fucilli, F Di Giovanni, G Giampaolo, N Pesole, PL Osella, AR AF Curci, Ritanna Bianco, Antonella Franco, Isabella Campanella, Angelo Mirizzi, Antonella Bonfiglio, Caterina Sorino, Paolo Fucilli, Fabio Di Giovanni, Giuseppe Giampaolo, Nicola Pesole, Pasqua Letizia Osella, Alberto Ruben TI The Effect of Low Glycemic Index Mediterranean Diet and Combined Exercise Program on Metabolic-Associated Fatty Liver Disease: A Joint Modeling Approach SO JOURNAL OF CLINICAL MEDICINE LA English DT Article DE lifestyle; fatty liver; metabolic dysfunction; combined exercise program; joint modelling ID PHYSICAL-ACTIVITY; WEIGHT-LOSS; RESISTANCE EXERCISE; INSULIN-RESISTANCE; OBESE INDIVIDUALS; AEROBIC EXERCISE; MANAGEMENT; INTERVENTIONS; METAANALYSIS; PREVENTION AB Background: Excessive caloric intake and reduced energy expenditure are associated with the onset of metabolic-associated fatty liver disease (MAFLD). The aim of this study was to probe the benefits of a low glycemic index Mediterranean diet (LGIMD) and a combined exercise program (CEP) on MAFLD by monitoring the clinical process through anthropometric measurement, body mass index (BMI), and specific biomarkers, such as the Homeostatic Model Assessment for Insulin Resistance (HOMA-IR). Methods: The study was conducted at the National Institute of Gastroenterology, 'S. de Bellis', Italy. Subjects were invited to join the study for 12 months. Results: 54 participants were enrolled. Joint modeling of longitudinal and time-to-event data was applied. Overall, a statistically significant direct effect of LGIMD/CEP adherence on ln (BMI), a statistically significant direct effect of LGIMD/CEP adherence on time-to-event and a strong statistically significant direct effect of log (BMI) on time-to-event were observed. In addition, a statistically significant direct effect of LGIMD/CEP adherence on ln(HOMA-IR), a statistically significant direct effect of LGIMD/CEP adherence on time-to-event and a statistically significant direct effect of ln(HOMA-IR) on time-to-event were observed. Conclusions: LGIMD/CEP significantly improved MAFLD status; in addition, longitudinal BMI and HOMA-IR were good predictors of the disappearance of diagnostic criteria for MAFLD. C1 [Curci, Ritanna; Bianco, Antonella; Franco, Isabella; Campanella, Angelo; Mirizzi, Antonella; Bonfiglio, Caterina; Osella, Alberto Ruben] S de Bellis Res Hosp, Natl Inst Gastroenterol, IRCCS, Lab Epidemiol & Stat, I-70013 Castellana Grotte, BA, Italy. [Sorino, Paolo] Polytech Bari, Dept Elect & Informat Engn, I-70126 Bari, BA, Italy. [Fucilli, Fabio; Di Giovanni, Giuseppe; Giampaolo, Nicola] S de Bellis Res Hosp, Natl Inst Gastroenterol, IRCCS, Dept Radiol, I-70013 Castellana Grotte, BA, Italy. [Pesole, Pasqua Letizia] S de Bellis Res Hosp, Natl Inst Gastroenterol, IRCCS, Lab Clin Pathol, I-70013 Castellana Grotte, BA, Italy. C3 IRCCS Saverio de Bellis; Politecnico di Bari; IRCCS Saverio de Bellis; IRCCS Saverio de Bellis RP Osella, AR (通讯作者)，S de Bellis Res Hosp, Natl Inst Gastroenterol, IRCCS, Lab Epidemiol & Stat, I-70013 Castellana Grotte, BA, Italy. EM ritanna.curci@irccsdebellis.it; antonella.bianco@irccsdebellis.it; isabella.franco@irccsdebellis.it; angelo.campanella@irccsdebellis.it; dottoressamirizzi@yahoo.com; catia.bonfiglio@irccsdebellis.it; paolo.sorino@poliba.it; fabiolucilli@irccsdebellis.it; giuseppe.digioyanni@irccsdebellis.it; nicola.giampaolo@irccsdebellis.it; letizia.pesole@irccsdebellis.it; arosella@irccsdebellis.it RI ; Sorino, Paolo/JFS-3040-2023; Osella, Alberto/M-6888-2014; Di Giovanni, Giuseppe/N-3047-2013 OI pesole, pasqua letizia/0000-0003-4675-2075; Sorino, Paolo/0000-0002-9081-2648; FRANCO, ISABELLA/0000-0002-3697-0127; Osella, Alberto/0000-0003-4232-8760; Campanella, Angelo/0000-0002-5044-4625; Bonfiglio, Caterina/0000-0002-8650-348X FU Italian Minister of Health [RC DCS n.864 19/12/2017, 740 10/10/2018] FX This research was funded in full by the Italian Minister of Health, grant number RC DCS n.864 19/12/2017; RC DDG n.740 10/10/2018. 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Clin. Med. PD AUG PY 2022 VL 11 IS 15 AR 4339 DI 10.3390/jcm11154339 PG 12 WC Medicine, General & Internal WE Science Citation Index Expanded (SCI-EXPANDED) SC General & Internal Medicine GA 3S0JH UT WOS:000839289200001 PM 35893431 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Cossiga, V Cazzagon, N Montalti, R Ciminnisi, S Attanasio, MR Pezzato, F Giacchetto, M Guarino, M Calvaruso, V Floreani, A Morisco, F AF Cossiga, Valentina Cazzagon, Nora Montalti, Roberto Ciminnisi, Stefania Attanasio, Maria Rosaria Pezzato, Francesco Giacchetto, Marco Guarino, Maria Calvaruso, Vincenza Floreani, Annarosa Morisco, Filomena TI The unhealthy lifestyle in primary biliary cholangitis: An enemy to fight SO DIGESTIVE AND LIVER DISEASE LA English DT Article DE Eating habits; Lifestyle; Metabolic syndrome; Primary biliary cholangitis; Physical activity ID ALL-CAUSE MORTALITY; MEDITERRANEAN DIET; RISK-FACTORS; FATTY-ACIDS; LIVER FAT; HEPATOCELLULAR-CARCINOMA; HEPATIC STEATOSIS; VISCERAL FAT; HYPERCHOLESTEROLEMIA; CIRRHOSIS AB Background and aim: Metabolic dysfunctions, particularly hyperlipidemia, are a common finding in Pri-mary Biliary Cholangitis (PBC). In presence of metabolic components of fatty-liver-disease (MAFLD), the liver fibrosis progression risk is higher. The aim of this study was to evaluate lifestyle of PBC patients compared to controls. Methods: In a prospective, multicenter study 107 PBC patients were enrolled; among these, 54 subjects were age-and sex-matched with 54 controls with a propensity-score-matching-analysis. Eating habits and physical activity were evaluated, respectively, with a food-frequency-questionnaire and with a short pre -validated-questionnaire. The adherence to Mediterranean diet was assessed with the alternate Mediter-ranean diet score.Results: The total fat intake was higher in controls than in PBC ( p = 0.004), unless above the national recommendations in both groups. Moreover, in PBC monounsaturated-fat and polyunsaturated-fatty-acid intakes and the adherence to Mediterranean diet were significantly lower than in controls ( p < 0.001, p = 0.0 05 and p < 0.0 01 respectively). Regarding physical activity, PBC subjects had a sedentary behavior as well as controls.Conclusions: The lifestyle of both PBC and controls is at high risk of developing MAFLD. Therefore, hep-atologists should regularly evaluate eating habits and physical activity in PBC patients and promote a lifestyle change to reduce liver disease progression risk.& COPY; 2022 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved. C1 [Cossiga, Valentina; Attanasio, Maria Rosaria; Guarino, Maria; Morisco, Filomena] Univ Naples Federico II, Dept Clin Med & Surg, Gastroenterol & Hepatol Unit, Naples, Italy. [Cazzagon, Nora; Pezzato, Francesco; Floreani, Annarosa] Univ Padua, Dept Surg Oncol & Gastroenterol, Padua, Italy. [Cazzagon, Nora] Azienda Osped Univ Padova, Gastroenterol Unit, Padua, Italy. [Montalti, Roberto] Univ Naples Federico II, Dept Publ Hlth, Div Hepatobilio Pancreat Minimally Invas & Robot S, Naples, Italy. [Ciminnisi, Stefania; Giacchetto, Marco; Calvaruso, Vincenza] Univ Palermo, Dept Hlth Promot Sci Maternal & Infantile Care, Gastrointestinal & Liver Unit, Internal Med & Med Specialties, Palermo, Italy. [Floreani, Annarosa] Sci Inst Res Hospitalizat & Healthcare, Verona, Italy. C3 University of Naples Federico II; University of Padua; University of Padua; Azienda Ospedaliera - Universita di Padova; University of Naples Federico II; University of Palermo RP Cossiga, V (通讯作者)，Univ Naples Federico II, Dept Clin Med & Surg, Gastroenterol & Hepatol Unit, Naples, Italy. EM valentina.cossiga@gmail.com RI morisco, filomena/AHI-0851-2022; Cazzagon, Nora/AEG-2437-2022; Morisco, Filomena/AHI-0851-2022; Cossiga, Valentina/ABB-3331-2021 OI morisco, filomena/0000-0002-9059-8311; Cazzagon, Nora/0000-0002-6937-8664; Morisco, Filomena/0009-0006-1537-5034; Cossiga, Valentina/0000-0002-0000-1076; Montalti, Roberto/0000-0002-3915-3851 CR AAVV. 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Liver Dis. PD JUN PY 2023 VL 55 IS 6 BP 778 EP 784 DI 10.1016/j.dld.2022.12.009 EA MAY 2023 PG 7 WC Gastroenterology & Hepatology WE Science Citation Index Expanded (SCI-EXPANDED) SC Gastroenterology & Hepatology GA K0FQ7 UT WOS:001013297100001 PM 36593159 DA 2026-02-02 ER PT J AU Curci, R Bianco, A Franco, I Bonfiglio, C Campanella, A Mirizzi, A Giannuzzi, V Cozzolongo, R Veronese, N Osella, AR AF Curci, Ritanna Bianco, Antonella Franco, Isabella Bonfiglio, Caterina Campanella, Angelo Mirizzi, Antonella Giannuzzi, Vito Cozzolongo, Raffaele Veronese, Nicola Osella, Alberto Ruben TI Lifestyle Modification: Evaluation of the Effects of Physical Activity and Low-Glycemic-Index Mediterranean Diet on Fibrosis Score SO NUTRIENTS LA English DT Article DE liver fibrosis; non-alcoholic fatty liver disease; physical activity; Mediterranean diet; lifestyle; chronic liver disease ID FATTY LIVER-DISEASE; RESISTANCE EXERCISE; HEPATIC STEATOSIS; STEATOHEPATITIS; PRODUCTS; FEATURES; LIPIDS; NAFLD; RISK AB Background: Non-Alcoholic Fatty Liver Disease (NAFLD) is one the most prevalent causes of chronic liver disease worldwide. In the absence of an approved drug treatment, lifestyle modification is the first intervention strategy. This study aimed to estimate the main effect of two different physical activity (PA) programs, and a Low-Glycemic-Index Mediterranean Diet (LGIMD), or their combined effect on liver fibrosis parameters in subjects with NAFLD. Methods: Subjects with moderate or severe NAFLD grade of severity (n = 144) were randomly assigned to six intervention arms for three months: LGIMD, PA programs, and their combination. Data were collected at baseline, 45 days, and 90 days. Transient elastography was performed to assess the outcome. Results: at 90 days, a statistically significant reduction in kPa was found among subjects following LGMID (-2.85, 95% CI -5.24, -0.45) and those following an LGIMD plus PA1 (-2.37, 95% CI -4.39, -0.35) and LGIMD plus Pa2 (-2.21, 95% CI -4.10, -0.32). The contrast between time 2 and time 1 of the LGIMD plus PA2 treatment showed a statistically significant increase, and vice versa: the contrast between time 3 and time 2 of the same treatment showed a statistically significant reduction. The PA1 and PA2 arms also showed reduced kPa, although the results did not reach statistical significance. Conclusions: The intervention arms, LGIMD, LGIMD+PA1, and LGIMD+PA2, reduced the fibrosis score. C1 [Curci, Ritanna; Bianco, Antonella; Franco, Isabella; Bonfiglio, Caterina; Campanella, Angelo; Osella, Alberto Ruben] Natl Inst Gastroenterol IRCCS S de Bellis, Lab Epidemiol & Stat, Via Turi, I-70013 Castellana Grotte, Italy. [Mirizzi, Antonella] Via Margher Savoia 93, I-70017 Putignano, Italy. [Giannuzzi, Vito; Cozzolongo, Raffaele] Natl Inst Gastroenterol IRCCS S de Bellis, Gastroenterol Unit, Via Turi, I-70013 Castellana Grotte, Italy. [Veronese, Nicola] Univ Palermo, Geriatr Unit, Dept Med, I-90100 Palermo, Italy. C3 University of Palermo RP Osella, AR (通讯作者)，Natl Inst Gastroenterol IRCCS S de Bellis, Lab Epidemiol & Stat, Via Turi, I-70013 Castellana Grotte, Italy. EM ritanna.curci@irccsdebellis.it; antonella.bianco@irccsdebellis.it; isabella.franco@irccsdebellis.it; catia.bonfiglio@irccsdebellis.it; angelo.campanella@irccsdebellis.it; dottoressamirizzi@yahoo.com; vito.giannuzzi@irccsdebellis.it; raffaele.cozzolongo@irccsedebellis.it; nicola.veronese@unipa.it; arosella@irccsdebellis.it RI ; Osella, Alberto/M-6888-2014; cozzolongo, raffaele/ABH-5696-2020; Veronese, Nicola/K-4343-2018 OI FRANCO, ISABELLA/0000-0002-3697-0127; Bonfiglio, Caterina/0000-0002-8650-348X; Campanella, Angelo/0000-0002-5044-4625; Osella, Alberto/0000-0003-4232-8760; Mirizzi, Antonella/0000-0003-1262-0015; Veronese, Nicola/0000-0002-9328-289X FU RC 2012-2014, Linea 4, C 32 [1159]; ApuliaRegion [D.D.n.110/2014] FX This work was supported by RC 2012-2014, Linea 4, C 32 (D.D.n.110/2014) and by ApuliaRegion D.G.R. n. 1159, 28 June 2018 and 2019. 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Beyond liver related complications such as cirrhosis and hepatocellular carcinoma, NAFLD is also an emerging risk factor for type 2 diabetes and cardiovascular disease. Currently, lifestyle intervention including strategies to reduce body weight and to increase regular physical activity represents the mainstay of NAFLD management. Total caloric intake plays a very important role in both the development and the treatment of NAFLD; however, apart from the caloric restriction alone, modifying the quality of the diet and modulating either the macro-or micronutrient composition can also markedly affect the clinical evolution of NAFLD, offering a more realistic and feasible treatment alternative. The aim of the present review is to summarize currently available evidence from randomized controlled trials on the effects of different nutrients including carbohydrates, lipids, protein and other dietary components, in isocaloric conditions, on NAFLD in people at high cardiometabolic risk. 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A. Fouda, Sherouk Pappachan, Joseph M. TI Management of metabolic-associated fatty liver disease: The diabetology perspective SO WORLD JOURNAL OF GASTROENTEROLOGY LA English DT Review DE Metabolic syndrome; Metabolic-associated fatty liver disease; Type 2 diabetes mellitus; Nonalcoholic fatty liver disease; Nonalcoholic steatohepatitis; Diabetology perspective; Obesity ID PLACEBO-CONTROLLED TRIAL; LIFE-STYLE MODIFICATION; GLUCAGON-LIKE PEPTIDE-1; DE-NOVO LIPOGENESIS; INSULIN-RESISTANCE; OBETICHOLIC ACID; HEPATOCELLULAR-CARCINOMA; MEDITERRANEAN DIET; BLADDER-CANCER; DOUBLE-BLIND AB The metabolic syndrome as a consequence of the obesity pandemic resulted in a substantial increase in the prevalence of metabolic-associated fatty live disease (MAFLD) and type 2 diabetes mellitus (T2DM). Because of the similarity in pathobiology shared between T2DM and MAFLD, both disorders coexist in many patients and may potentiate the disease-related outcomes with rapid progression and increased complications of the individual diseases. In fact, awareness about this coexistence and the risk of complications are often overlooked by both hepatologists and diabetologists. Management of these individual disorders in a patient should be addressed wholistically using an appropriate multidisciplinary team approach involving both the specialists and, when necessary, liaising with dieticians and surgeons. This comprehensive review is to compile the current evidence from a diabetologist's perspective on MAFLD and T2DM and to suggest optimal management strategies. C1 [Jeeyavudeen, Mohammad Sadiq] Univ Hosp Edinburgh, Dept Endocrinol & Metab, Edinburgh EH4 2XU, Scotland. [Khan, Shahanas K. A.; Pappachan, Joseph M.] Lancashire Teaching Hosp NHS Trust, Dept Endocrinol & Metab, Preston PR2 9HT, England. [Fouda, Sherouk] RMIT Univ, Sch Hlth & Biomed Sci, Melbourne, Vic 3046, Australia. [Pappachan, Joseph M.] Manchester Metropolitan Univ, Fac Sci, Manchester M15 6BH, Lancs, England. [Pappachan, Joseph M.] Univ Manchester, Fac Biol, Manchester M13 9PL, England. [Pappachan, Joseph M.] Lancashire Teaching Hosp NHS Trust, Dept Endocrinol & Metab, Sharoe Green Lane, Preston PR2 9HT, England. C3 Royal Melbourne Institute of Technology (RMIT); Manchester Metropolitan University; University of Manchester RP Pappachan, JM (通讯作者)，Lancashire Teaching Hosp NHS Trust, Dept Endocrinol & Metab, Sharoe Green Lane, Preston PR2 9HT, England. 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Gastroenterol. PD JAN 7 PY 2023 VL 29 IS 1 BP 126 EP 143 DI 10.3748/wjg.v29.i1.126 PG 18 WC Gastroenterology & Hepatology WE Science Citation Index Expanded (SCI-EXPANDED) SC Gastroenterology & Hepatology GA 8F3CK UT WOS:000919543600008 PM 36683717 OA Green Submitted, hybrid DA 2026-02-02 ER PT J AU Aller, R Sigüenza, R Pina, M Laserna, C Antolín, B Burgueño, B Durà, M Izaola, O Primo, D de Luis, DA AF Aller, Rocio Siguenza, Rebeca Pina, Maria Laserna, Cristina Antolin, Beatriz Burgueno, Beatriz Dura, Miguel Izaola, Olatz Primo, David de Luis, Daniel Antonio TI Insulin resistance is related with liver fibrosis in type 2 diabetic patients with non-alcoholic fatty liver disease proven biopsy and Mediterranean diet pattern as a protective factor SO ENDOCRINE LA English DT Article DE Fibrosis; Liver biopsy; Non-alcoholic fatty liver disease; Type 2 diabetes mellitus ID METABOLIC-SYNDROME; CHRONIC HEPATITIS; STEATOHEPATITIS; ASSOCIATION; MANAGEMENT; RISK; CHOLESTEROL; PREVALENCE; CRITERIA; HISTORY AB Background and aims The prevalence of the non-alcoholic fatty liver disease (NAFLD) in developed countries is up to 30% of the general population, and 50% of patients present type 2 diabetes mellitus (DM2). Fibrosis is the most important prognostic factor in NAFLD. The aim of this study was to search evidence for an early diagnosis of liver fibrosis in subjects with DM2 and to evaluate potential risk and protective factors. Methods This study was conducted among 160 diabetic patients with NAFLD proven biopsy. Anthropometric assessments, laboratory test, liver histological features and follow-up of a Mediterranean diet were evaluated. Results Diabetic patients with liver fibrosis showed a greater number of positive metabolic criteria than diabetic patients without liver fibrosis. Patients with hepatic fibrosis have a lower score on the PREDIMED test (9.0 (2.4) vs. 6.2 (2.3); p < 0.05). Diabetic patients with liver fibrosis showed higher glucose levels (delta: 10.1 (4.5) mg/dl), fasting insulin levels (delta: 3.1 (1.5) UI/L), HOMA-IR (delta: 2.1 (0.3) units) and HbA1c (delta: 0.6 (0.2)%). Non-invasive tests showed a higher score (non-alcoholic fatty liver disease fibrosis score and fibrosis-4) in liver fibrosis subjects than no liver fibrosis subjects. A logistic regression analysis adjusted by age, gender, HbA1c and body mass index showed independent significant direct association between liver fibrosis and homeostatic model assessment of insulin resistance as indicator of insulin resistance (odds ratio (OR) = 1.53: 95% confidence interval (CI): 1.1-2.2; p = 0.026) and inverse association with PREDIMED score as an indicator of adherence to Mediterranean diet (OR = 0.6; 95% CI: 0.4-0.8; p = 0.01). Conclusion In patients with DM2, insulin resistance is an independent risk factor associated with liver fibrosis, and the adherence of a Mediterranean diet is a protective factor associated with absence of liver fibrosis. C1 [Aller, Rocio; Laserna, Cristina; Izaola, Olatz; Primo, David; de Luis, Daniel Antonio] Med Sch, Ctr Invest Endocrinol & Nutr, Valladolid 47130, Spain. [Aller, Rocio; Laserna, Cristina; Izaola, Olatz; Primo, David; de Luis, Daniel Antonio] Univ Valladolid, Valladolid 47130, Spain. [Aller, Rocio; Antolin, Beatriz; Burgueno, Beatriz; Dura, Miguel] Univ Valladolid, Dept Digest, Hosp Clin, Valladolid, Spain. [Siguenza, Rebeca; Pina, Maria] Univ Valladolid, Dept Radiol, Hosp Clin, Valladolid, Spain. [Izaola, Olatz; Primo, David; de Luis, Daniel Antonio] Univ Valladolid, Dept Endocrinol & Nutr, Hosp Clin, Valladolid, Spain. C3 Universidad de Valladolid; Universidad de Valladolid; Universidad de Valladolid; Universidad de Valladolid RP de Luis, DA (通讯作者)，Med Sch, Ctr Invest Endocrinol & Nutr, Valladolid 47130, Spain.; de Luis, DA (通讯作者)，Univ Valladolid, Valladolid 47130, Spain. EM dadluis@yahoo.es RI ALLER, ROCIO/JXM-2497-2024; de luis roman, Daniel/HKN-3846-2023 OI LASERNA DEL GALLEGO, CRISTINA/0009-0007-2888-9234; DURÁ GIL, MIGUEL/0009-0004-0063-6276 CR Abenavoli L, 2014, WORLD J GASTROENTERO, V20, P16831, DOI 10.3748/wjg.v20.i45.16831 Adams LA, 2005, GASTROENTEROLOGY, V129, P113, DOI 10.1053/j.gastro.2005.04.014 Adams LA, 2005, CAN MED ASSOC J, V172, P899, DOI 10.1503/cmaj.045232 Martínez-González MA, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0043134 Angulo P, 2007, HEPATOLOGY, V45, P846, DOI 10.1002/hep.21496 [Anonymous], 2018, DIABETES CARE, V41, pS1, DOI [10.2337/dc18-SINT01, 10.2337/dc18-Sint01] Bhatt HB, 2015, HEPATOBIL SURG NUTR, V4, P101, DOI 10.3978/j.issn.2304-3881.2015.01.03 Brunt EM, 2010, NAT REV GASTRO HEPAT, V7, P195, DOI 10.1038/nrgastro.2010.21 Bugianesi E, 2016, DIABETOLOGIA, V59, P1145, DOI 10.1007/s00125-016-3930-7 Caballería L, 2012, EUR J GASTROEN HEPAT, V24, P1007, DOI 10.1097/MEG.0b013e328355b87f Chalasani N, 2012, HEPATOLOGY, V55, P2005, DOI 10.1002/hep.25762 Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486 COCCIA F, 2019, NUTR METAB CARDIOVAS, V30 Cusi K, 2009, CURR OPIN ENDOCRINOL, V16, P141, DOI 10.1097/MED.0b013e3283293015 Fan JG, 2008, J DIGEST DIS, V9, P63, DOI 10.1111/j.1751-2980.2008.00323.x Fracanzani AL, 2008, HEPATOLOGY, V48, P792, DOI 10.1002/hep.22429 FRIEDEWALD WT, 1972, CLIN CHEM, V18 Grundy SM, 2004, CIRCULATION, V109, P433, DOI 10.1161/01.CIR.0000112379.88385.67 Gupte P, 2004, J GASTROEN HEPATOL, V19, P854, DOI 10.1111/j.1440-1746.2004.03312.x Harrison SA, 2008, GUT, V57, P1441, DOI 10.1136/gut.2007.146019 Lok ASF, 2009, HEPATOLOGY, V50, P661, DOI 10.1002/hep.23190 Lonardo A, 2016, METABOLISM, V65, P1136, DOI 10.1016/j.metabol.2015.09.017 Loomba R, 2012, HEPATOLOGY, V56, P943, DOI 10.1002/hep.25772 LUKASKI HC, 1985, AM J CLIN NUTR, V41, P810, DOI 10.1093/ajcn/41.4.810 Marchesini G, 2003, HEPATOLOGY, V37, P917, DOI 10.1053/jhep.2003.50161 MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883 Nettschwander-Tetri BA, 2010, HEPATOLOGY, V52, P913, DOI 10.1002/hep.23784 Oh HJ, 2011, KOREAN J HEPATOL, V17, P27, DOI DOI 10.3350/KJHEP.2011.17.1.27 Puchakayala BK, 2015, WORLD J HEPATOL, V7, P2610, DOI 10.4254/wjh.v7.i25.2610 REES K, 2012, COCHRANE DB SYST REV, V8, P1 Riazi K, 2019, NUTRIENTS, V11, DOI 10.3390/nu11122878 Spahis S, 2017, ANTIOXID REDOX SIGN, V26, P519, DOI 10.1089/ars.2016.6776 Speliotes EK, 2010, HEPATOLOGY, V51, P1979, DOI 10.1002/hep.23593 Svegliati-Baroni G, 2007, GUT, V56, P1296, DOI 10.1136/gut.2006.107946 Targher G, 2010, DIABETOLOGIA, V53, P1341, DOI 10.1007/s00125-010-1720-1 Targher G, 2010, J HEPATOL, V53, P713, DOI 10.1016/j.jhep.2010.04.030 Valdés S, 2014, REV ESP CARDIOL, V67, P442, DOI [10.1016/j.recesp.2013.09.031, 10.1016/j.rec.2013.09.029] Vilar-Gomez E, 2015, GASTROENTEROLOGY, V149, P367, DOI 10.1053/j.gastro.2015.04.005 Zhao HL, 2018, MEDICINE, V97, DOI 10.1097/MD.0000000000012356 NR 39 TC 39 Z9 41 U1 0 U2 6 PU SPRINGER PI NEW YORK PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES SN 1355-008X EI 1559-0100 J9 ENDOCRINE JI Endocrine PD JUN PY 2020 VL 68 IS 3 BP 557 EP 563 DI 10.1007/s12020-020-02268-7 EA APR 2020 PG 7 WC Endocrinology & Metabolism WE Science Citation Index Expanded (SCI-EXPANDED) SC Endocrinology & Metabolism GA MA3RC UT WOS:000522893700001 PM 32239453 DA 2026-02-02 ER PT J AU Doustmohammadian, A Clark, CCT Maadi, M Motamed, N Sobhrakhshankhah, E Ajdarkosh, H Mansourian, MR Esfandyari, S Hanjani, NA Nikkhoo, M Zamani, F AF Doustmohammadian, Azam Clark, Cain C. T. Maadi, Mansooreh Motamed, Nima Sobhrakhshankhah, Elham Ajdarkosh, Hossein Mansourian, Mohsen Reza Esfandyari, Saeed Hanjani, Nazanin Asghari Nikkhoo, Mahsa Zamani, Farhad TI Favorable association between Mediterranean diet (MeD) and DASH with NAFLD among Iranian adults of the Amol Cohort Study (AmolCS) SO SCIENTIFIC REPORTS LA English DT Article ID FATTY LIVER-DISEASE; STOP HYPERTENSION DASH; ACID LOAD; ADHERENCE; RISK; PREVENTION AB Nonalcoholic fatty liver disease (NAFLD) is an emerging cause of chronic liver diseases and a major health problem worldwide. Dietary patterns may play a critical role in controlling and preventing this disease, but the available evidence is scarce. The current study aims to ascertain the association of adherence to the Dietary Approach to Stop Hypertension (DASH) diet and Mediterranean diet (MeD) with nonalcoholic fatty liver disease (NAFLD) among Iranian adults of the Amol Cohort Study (AmolCS). In a cross-sectional analysis among 3220 adults (55.3% men), age >= 18 years (46.96 +/- 14.67), we measured usual dietary intake with a validated food frequency questionnaire (FFQ) and then calculated dietary pattern scores for DASH and MeD. Sociodemographic and lifestyle factors were collected by a structured questionnaire. The presence and degree of NAFLD were also determined by abdominal sonography. Multiple regression models were used to estimate NAFLD odds across tertiles of DASH and Mediterranean dietary scores. Dietary DASH and Mediterranean components were adjusted for total energy intake, based on the residual methods. After adjusting for multiple potential confounders, we found an inverse association of DASH and MeD with NAFLD (Ptrend = 0.02, and Ptrend = 0.002, respectively). Those in the highest tertiles of adherence to the DASH and MeD had the lowest risk for NAFLD (OR = 0.80, 95%CI = 0.66-0.96, OR = 0.64, 95%CI = 0.52-0.78, respectively). The results of logistic analysis of MeD, stratified by gender and abdominal obesity, revealed the favorable association was more pronounced in women (OR = 0.42, 95%CI = 0.29-0.61, Ptrend = 0.004), and in participants with or without abdominal obesity (OR = 0.62, 95% CI = 0.47-0.81, Ptrend = 0.03, OR = 0.64, 95%CI = 0.475-0.91, Ptrend = 0.04, respectively). Similar results were obtained for the adherence to DASH diet score with the prevalence of NAFLD patients with abdominal obesity (OR = 0.75, 95% CI = 0.57-0.97, Ptrend = 0.04). The findings suggested the favorable association between DASH and MeD with NAFLD in Iranian adults, especially women and subjects with or without abdominal obesity. Further prospective investigations are needed to confirm the integrity of our findings. C1 [Doustmohammadian, Azam; Maadi, Mansooreh; Sobhrakhshankhah, Elham; Ajdarkosh, Hossein; Mansourian, Mohsen Reza; Nikkhoo, Mahsa; Zamani, Farhad] Iran Univ Med Sci, Gastrointestinal & Liver Dis Res Ctr, Behafarin St,Karimkhan Ave,Vali Asr Sq, Tehran 1449614535, Iran. [Clark, Cain C. T.] Coventry Univ, Ctr Intelligent Healthcare, Coventry CV1 5FB, W Midlands, England. [Motamed, Nima] Zanjan Univ Med Sci, Dept Social Med, Zanjan, Iran. [Esfandyari, Saeed] Asadabad Sch Med Sci, Asadabad, Hamadan, Iran. [Hanjani, Nazanin Asghari] Iran Univ Med Sci, Sch Publ Hlth, Tehran, Iran. C3 Iran University of Medical Sciences; Coventry University; Iran University of Medical Sciences RP Zamani, F (通讯作者)，Iran Univ Med Sci, Gastrointestinal & Liver Dis Res Ctr, Behafarin St,Karimkhan Ave,Vali Asr Sq, Tehran 1449614535, Iran. EM zamani.farhad@gmail.com RI Doustmohammadian, Azam/HNQ-0687-2023; Clark, Cain/I-4480-2019; Zamani, Farhad/ABH-8503-2020; Motamed, Nima/N-6095-2016 OI Doustmohammadian, Azam/0000-0001-6249-2520; Sobhrakhshankhah, Elham/0000-0002-2078-213X; Clark, Cain/0000-0002-6610-4617; Nikkhoo, mahsa/0000-0002-6106-3254 FU Gastrointestinal and liver Diseases Research Center (GILDRC), Iran University of Medical Sciences (IUMS) [99-2-30-19054] FX This research was conducted by a grant from the Gastrointestinal and liver Diseases Research Center (GILDRC), Iran University of Medical Sciences (IUMS) (Grant No: 99-2-30-19054). 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Sid, Victoria Wang, Pengqi Siow, Yaw L. House, James D. Karmin, O. TI Tyrosol Attenuates High Fat Diet-Induced Hepatic Oxidative Stress: Potential Involvement of Cystathionine β-Synthase and Cystathionine γ-Lyase SO LIPIDS LA English DT Article; Proceedings Paper CT Northern Great Plains Lipid Conference CY MAY 31-JUN 01, 2015 CL Univ Manitoba, Winnipeg, CANADA HO Univ Manitoba DE Tyrosol; Oxidative stress; Non-alcoholic fatty liver disease; Hydrogen sulfide ID VIRGIN OLIVE OIL; LIVER-DISEASE; MEDITERRANEAN DIET; CARDIOVASCULAR-DISEASE; LIPID-PEROXIDATION; HYDROXYTYROSOL; ACID; STEATOHEPATITIS; PERSPECTIVE; EXPRESSION AB The Mediterranean diet is known for its cardioprotective effects. Recently, its protective qualities have also been reported in patients with non-alcoholic fatty liver disease (NAFLD). Oxidative stress is one of the important factors responsible for the development and progression of NAFLD. Hydrogen sulfide (H2S), a multifaceted gasotransmitter, has emerged as a potential therapeutic target in NAFLD. Cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE) are major enzymes responsible for endogenous H2S synthesis. Since oxidative stress contributes to NAFLD pathogenesis, the objective of this study was to investigate the effect of tyrosol, a major compound in olive oil and white wine, on high fat diet-induced hepatic oxidative stress and the mechanisms involved. Mice (C57BL/6) were fed for 5 weeks with a control diet (10 % kcal fat), a high fat diet (60 % kcal fat, HFD) or a HFD supplemented with tyrosol. High fat diet feeding induced hepatic oxidative stress, as indicated by the significant increase in lipid peroxidation and NADPH oxidase activity. Tyrosol supplementation significantly increased hepatic CBS and CSE expression and H2S synthesis in high fat diet-fed mice. Such effects were associated with the attenuation of high fat diet-induced hepatic lipid peroxidation and the restoration of the redox equilibrium of the antioxidant glutathione. Tyrosol also inhibited palmitic acid-induced oxidative stress in hepatocytes (HepG2 cells). These results suggest that the antioxidant properties of tyrosol may be mediated through functional changes in CBS and CSE activity, which might contribute to the hepatoprotective effect of the Mediterranean diet. C1 [Sarna, Lindsei K.; Sid, Victoria; Wang, Pengqi; Siow, Yaw L.; Karmin, O.] CCARM, St Boniface Hosp Res Ctr, 351 Tache Ave, Winnipeg, MB R2H 2A6, Canada. [Sarna, Lindsei K.; Wang, Pengqi; Karmin, O.] Univ Manitoba, Dept Anim Sci, Winnipeg, MB R3T 2N2, Canada. [Sid, Victoria; Siow, Yaw L.; House, James D.; Karmin, O.] Univ Manitoba, Dept Physiol, Winnipeg, MB, Canada. [Siow, Yaw L.] Univ Manitoba, Agr & Agri Food Canada, Winnipeg, MB, Canada. [House, James D.] Univ Manitoba, Dept Human Nutr Sci, Winnipeg, MB, Canada. C3 University of Manitoba; Children's Hospital Research Institute of Manitoba; Saint Boniface Hospital; University of Manitoba; University of Manitoba; University of Manitoba; Agriculture & Agri Food Canada; University of Manitoba RP Karmin, O (通讯作者)，CCARM, St Boniface Hosp Res Ctr, 351 Tache Ave, Winnipeg, MB R2H 2A6, Canada.; Karmin, O (通讯作者)，Univ Manitoba, Dept Anim Sci, Winnipeg, MB R3T 2N2, Canada.; Karmin, O (通讯作者)，Univ Manitoba, Dept Physiol, Winnipeg, MB, Canada. 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Bouzas, Cristina Montemayor, Sofia Casares, Miguel Gomez, Cristina Ugarriza, Lucia Borras, Pere-Antoni Martinez, Jose Alfredo Tur, Josep A. TI Association between Physical Activity and Non-Alcoholic Fatty Liver Disease in Adults with Metabolic Syndrome: The FLIPAN Study SO NUTRIENTS LA English DT Article DE physical activity; Mediterranean diet; Mediterranean lifestyle; metabolic syndrome; non-alcoholic fatty liver disease ID ACTIVITY QUESTIONNAIRE; EXERCISE; VALIDATION; OVERWEIGHT; PATTERNS; PEOPLE; DIET; RISK AB Background: A lifestyle with regular PA (physical activity) and Mediterranean diet has benefits on NAFLD (non-alcoholic fatty liver disease) and MetS (metabolic syndrome). Objectives: To assess the association between physical activity and NAFLD in adults with MetS. Design: Cross-sectional study in 155 participants (40-60 years old) from Balearic Islands and Navarra (Spain) with diagnosis of NAFLD and MetS, and BMI (body mass index) between 27 and 40 Kg/m(2). Methods: PA level was categorized into two groups according to weekly METs (metabolic equivalents of tasks). PA was assessed using a validated Minnesota questionnaire and accelerometers. MetS parameters were assessed by blood collection analysis and NAFLD by abdominal MRI (magnetic resonance imaging). Results: Participants with high PA showed more energy expenditure and expended more calories than ingested (-143.9 Kcal/day; p < 0.001). PA was a risk factor for AST (aspartate aminotransferase) (adjusted OR: 7.26; 95% CI: 1.79-29.40) and a protective factor for ALT (alanine aminotransferase) (adjusted OR: 0.24; 95% CI: 0.12-0.48), GGT (gamma-glutamyl transferase) (adjusted OR: 0.52; 95% CI: 0.29-0.94) and IFC-NMR (intrahepatic fat content by nuclear magnetic resonance) (adjusted OR: 0.26; 95% CI: 0.12-0.56) when sociodemographic confounders were considered. Conclusions: NAFLD patients with high PA showed more positive relationship on MetS parameters and liver profile (ALT, GGT, IFC-NMR) than subjects with low PA, but not for AST. Difference between calories ingested and expended influenced this relationship. C1 [Mascaro, Catalina M.; Bouzas, Cristina; Montemayor, Sofia; Gomez, Cristina; Ugarriza, Lucia; Tur, Josep A.] Univ Balearic Isl, Res Grp Community Nutr & Oxidat Stress, Palma de Mallorca 07122, Spain. [Mascaro, Catalina M.; Bouzas, Cristina; Montemayor, Sofia; Gomez, Cristina; Ugarriza, Lucia; Tur, Josep A.] Hlth Inst Balear Isl IDISBA, Palma de Mallorca 07120, Spain. [Mascaro, Catalina M.; Bouzas, Cristina; Montemayor, Sofia; Tur, Josep A.] Inst Salud Carlos III ISCIII, CIBEROBN Physiopathol Obes & Nutr CB12 03 30038, Madrid 28029, Spain. [Casares, Miguel] Radiodiag Serv, Palma de Mallorca 07011, Spain. [Gomez, Cristina] Univ Hosp Son Espases, Clin Anal Serv, Palma de Mallorca 07120, Spain. [Ugarriza, Lucia] Camp Redo Primary Hlth Care Ctr, Palma de Mallorca 07010, Spain. [Borras, Pere-Antoni] Univ Balearic Isl, Dept Pedag & Specif Didact, Palma de Mallorca 07122, Spain. [Martinez, Jose Alfredo] UAM, CSIC, CEI, Cardiometabol Precis Nutr Program,IMDEA Food, Madrid 28049, Spain. C3 Universitat de les Illes Balears; CIBER - Centro de Investigacion Biomedica en Red; CIBEROBN; Hospital Universitari Son Espases; Universitat de les Illes Balears; Autonomous University of Madrid; IMDEA Food Institute; Consejo Superior de Investigaciones Cientificas (CSIC) RP Tur, JA (通讯作者)，Univ Balearic Isl, Res Grp Community Nutr & Oxidat Stress, Palma de Mallorca 07122, Spain.; Tur, JA (通讯作者)，Hlth Inst Balear Isl IDISBA, Palma de Mallorca 07120, Spain.; Tur, JA (通讯作者)，Inst Salud Carlos III ISCIII, CIBEROBN Physiopathol Obes & Nutr CB12 03 30038, Madrid 28029, Spain. EM cristina.bouzas@uib.es; cristina.bouzas@uib.es; cristina.bouzas@uib.es; casaresmiguel@gmail.com; cristina.bouzas@uib.es; cristina.bouzas@uib.es; pa-borras@uib.es; jalfredo.martinez@imdea.org; cristina.bouzas@uib.es RI BORRAS, PERE A/H-2403-2013; Tur, Josep/AAE-5748-2020; Bouzas, Cristina/AAE-2069-2019; Martínez, J./K-8709-2014 OI BORRAS, PERE A/0000-0001-6793-7592; Tur, Josep/0000-0002-6940-0761; GOMEZ COBO, CRISTINA/0000-0002-9776-4730; Bouzas Velasco, Cristina/0000-0002-1407-8461; FU Fundo La Marato TV3 (Spain) project [201630.10]; Instituto de Salud Carlos III through the CIBEROBN [CB12/03/30038]; European Regional Development Fund; IDISBA grants; Spanish Ministry of Education FX Fundo La Marato TV3 (Spain) project ref. 201630.10. Instituto de Salud Carlos III through the CIBEROBN CB12/03/30038, and Proyecto Intramural CIBER OBN18PI03, which are co-funded by the European Regional Development Fund. Other funding received: IDISBA grants (FOLIUM, PRIMUS, SYNERGIA, and LIBERI). Catalina M. Mascaro received an FPU PhD grant from the Spanish Ministry of Education. The funding sponsors had no role in the design of the study, in the collection, analyses, or interpretation of the data; in the writing of the manuscript, or in the decision to publish the results. 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With expanding knowledge on NAFLD pathogenesis, insights have been gleaned into molecular targets for pharmacologic and nonpharmacologic approaches. Lifestyle modifications constitute a cornerstone of NAFLD management. This article reviews roles of key dietary macronutrients and micronutrients in NAFLD pathogenesis and their effects on molecular targets shared with established or emerging pharmacotherapies. Based on current evidence, a recommendation for a dietary framework as part of the comprehensive management strategy for NAFLD is provided. C1 [Chakravarthy, Manu, V] Axcella Hlth Inc, 840 Mem Dr, Cambridge, MA 02139 USA. [Waddell, Thomas; Banerjee, Rajarshi] Perspectum Diagnost, 23-38 Hythe Bridge St, Oxford OX1 2ET, England. [Banerjee, Rajarshi] Oxford Univ Hosp NHS Fdn Trust, Headley Way, Oxford OX3 9DU, England. [Guess, Nicola] Kings Coll London, 150 Stamford St, London SE1 9NH, England. [Guess, Nicola] Univ Westminster, 101 New Cavendish St, London W1W 6XH, England. 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Clin. North Am. PD MAR PY 2020 VL 49 IS 1 BP 63 EP + DI 10.1016/j.gtc.2019.09.003 PG 33 WC Gastroenterology & Hepatology WE Science Citation Index Expanded (SCI-EXPANDED) SC Gastroenterology & Hepatology GA KM6MF UT WOS:000514251500007 PM 32033765 OA hybrid DA 2026-02-02 ER PT J AU Kosmalski, M Frankowski, R Ziólkowska, S Rózycka-Kosmalska, M Pietras, T AF Kosmalski, Marcin Frankowski, Rafal Ziolkowska, Sylwia Rozycka-Kosmalska, Monika Pietras, Tadeusz TI What's New in the Treatment of Non-Alcoholic Fatty Liver Disease (NAFLD) SO JOURNAL OF CLINICAL MEDICINE LA English DT Review DE non-alcoholic fatty liver disease; treatment; lifestyle intervention ID DOUBLE-BLIND; INSULIN-RESISTANCE; HEPATIC STEATOSIS; SUPPLEMENTATION; FIBROSIS; INHIBITION; INDEXES; TRIAL AB Non-alcoholic fatty liver disease (NAFLD) is a serious health problem due to its high incidence and consequences. In view of the existing controversies, new therapeutic options for NAFLD are still being sought. Therefore, the aim of our review was to evaluate the recently published studies on the treatment of NAFLD patients. We searched for articles in the PubMed database using appropriate terms, including "non-alcoholic fatty liver disease", "nonalcoholic fatty liver disease", "NAFLD", "diet", "treatment", "physical activity", "supplementation", "surgery", "overture" and "guidelines". One hundred forty-eight randomized clinical trials published from January 2020 to November 2022 were used for the final analysis. The results show significant benefits of NAFLD therapy associated with the use of not only the Mediterranean but also other types of diet (including low-calorie ketogenic, high-protein, anti-inflammatory and whole-grain diets), as well as enrichment with selected food products or supplements. Significant benefits in this group of patients are also associated with moderate aerobic physical training. The available therapeutic options indicate, above all, the usefulness of drugs related to weight reduction, as well as the reduction in insulin resistance or lipids level and drugs with anti-inflammatory or antioxidant properties. The usefulness of therapy with dulaglutide and the combination of tofogliflozin with pioglitazone should be emphasized. Based on the results of the latest research, the authors of this article suggest a revision of the therapeutic recommendations for NAFLD patients. C1 [Kosmalski, Marcin; Pietras, Tadeusz] Med Univ Lodz, Dept Clin Pharmacol, PL-90153 Lodz, Poland. [Frankowski, Rafal] Med Univ Lodz, Dept Clin Pharmacol, Students Res Club, PL-90153 Lodz, Poland. [Ziolkowska, Sylwia] Med Univ Lodz, Dept Med Biochem, PL-92215 Lodz, Poland. [Rozycka-Kosmalska, Monika] Med Univ Lodz, Dept Clin Electrocardiol, PL-92213 Lodz, Poland. C3 Medical University Lodz; Medical University Lodz; Medical University Lodz; Medical University Lodz RP Kosmalski, M (通讯作者)，Med Univ Lodz, Dept Clin Pharmacol, PL-90153 Lodz, Poland. EM marcin.kosmalski@umed.lodz.pl RI Kosmalski, Marcin/ADI-7757-2022 OI Kosmalski, Marcin/0000-0003-0609-9657; Ziolkowska, Sylwia/0000-0001-8140-3853; Pietras, Tadeusz/0000-0003-1771-3819 FU Medical University of Lodz [503/1-151-07/503-11-001-18] FX This research was funded by the Medical University of Lodz, institutional grant no. 503/1-151-07/503-11-001-18. 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Clin. Med. PD MAR PY 2023 VL 12 IS 5 AR 1852 DI 10.3390/jcm12051852 PG 27 WC Medicine, General & Internal WE Science Citation Index Expanded (SCI-EXPANDED) SC General & Internal Medicine GA 9U3ZS UT WOS:000947653900001 PM 36902639 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Hao, XY Song, H Su, X Li, J Ye, YB Wang, CL Xu, X Pang, GL Liu, WX Li, ZH Luo, T AF Hao, Xiangyong Song, Hao Su, Xin Li, Jian Ye, Youbao Wang, Cailiu Xu, Xiao Pang, Guanglong Liu, Wenxiu Li, Zihan Luo, Tian TI Prophylactic effects of nutrition, dietary strategies, exercise, lifestyle and environment on nonalcoholic fatty liver disease SO ANNALS OF MEDICINE LA English DT Review DE Nonalcoholic fatty liver disease; nutrition; dietary strategies; exercise; lifestyle; environment; prevention ID STOP HYPERTENSION DASH; METABOLIC SYNDROME; WEIGHT-LOSS; ALCOHOL-CONSUMPTION; CARDIOVASCULAR-DISEASE; COFFEE CONSUMPTION; INSULIN-RESISTANCE; PHYSICAL-ACTIVITY; NUT CONSUMPTION; PASSIVE SMOKING AB BackgroundNonalcoholic fatty liver disease (NAFLD) is a chronic liver disease and its prevalence has risen sharply. However, whether nutrition, dietary strategies, exercise, lifestyle and environment have preventive value for NAFLD remains unclear.MethodsThrough searching 4 databases (PubMed, Web of Science, Embase and the Cochrane Library) from inception to January 2025, we selected studies about nutrition, dietary strategies, exercise, lifestyle and environment in the prevention of NAFLD and conducted a narrative review on this topic.ResultsReasonable nutrient intake encompassing macronutrients and micronutrients have an independent protective relationship with NAFLD. Besides, proper dietary strategies including mediterranean diet, intermittent fasting diet, ketogenic diet, and dietary approaches to stop hypertension diet have their inhibitory effects on the developmental process of NAFLD. Moreover, right exercises including walking, jogging, bicycling, and swimming are recommended for the prevention of NAFLD because they could effectively reduce weight, which is an important risk factor for NAFLD, and improve liver function. In addition, embracing a healthy lifestyle including reducing sedentary behavior, not smoking, sleeping well and brushing teeth regularly is integral since it not only could reduce the risk of NAFLD but also significantly contribute to overall prevention and control. Finally, the environment, including the social and natural environments, plays a potential role in NAFLD prevention.ConclusionNutrition, dietary strategies, exercise, lifestyle and environment play an important role in the prevention of NAFLD. Moreover, this review offers comprehensive prevention recommendations for people at high risk of NAFLD. C1 [Hao, Xiangyong; Su, Xin; Li, Jian; Ye, Youbao; Wang, Cailiu; Xu, Xiao; Pang, Guanglong; Liu, Wenxiu] Gansu Prov Hosp, Dept Gen Surg, 204 Donggang West Rd, Lanzhou 730000, Peoples R China. [Song, Hao; Su, Xin; Li, Jian; Ye, Youbao; Wang, Cailiu; Xu, Xiao; Pang, Guanglong; Liu, Wenxiu; Li, Zihan] Gansu Univ Chinese Med, Gansu Prov Hosp, Dept Clin Med, Clin Med Coll 1, Lanzhou, Peoples R China. [Luo, Tian] Gansu Prov Hosp, Inst Clin Res & Translat Med, Lanzhou 730000, Peoples R China. C3 Gansu University of Chinese Medicine RP Hao, XY (通讯作者)，Gansu Prov Hosp, Dept Gen Surg, 204 Donggang West Rd, Lanzhou 730000, Peoples R China.; Luo, T (通讯作者)，Gansu Prov Hosp, Inst Clin Res & Translat Med, Lanzhou 730000, Peoples R China. EM haoxy-2008@163.com; luotianil@163.com OI Song, Hao/0009-0003-6158-0408; Hao, Xiang-Yong/0000-0003-4419-7047 FU Natural Science Foundation of Gansu Province [23JRRA1313]; Natural Science Foundation for Young Scientists; Science & Technology Planning Project of Gansu Province [18JR3RA058]; Gansu Province Youth Innovative Talents Project [2021LQGR15]; Health Industry Scientific Research Program of Gansu Province [GSWSKY2020-06]; Research Projects of Gansu Provincial Hospital [19SYPYB-7, 18GSSY3-1] FX This work was supported by Natural Science Foundation of Gansu Province (Grant No.: 23JRRA1313), Natural Science Foundation for Young Scientists and the Science & Technology Planning Project of Gansu Province (Grant No.: 18JR3RA058), Gansu Province Youth Innovative Talents Project (Grant No.: 2021LQGR15), Health Industry Scientific Research Program of Gansu Province (Grant No.: GSWSKY2020-06), and Research Projects of Gansu Provincial Hospital (Grant No.: 19SYPYB-7, 18GSSY3-1). 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Med. PD DEC 31 PY 2025 VL 57 IS 1 AR 2464223 DI 10.1080/07853890.2025.2464223 PG 24 WC Medicine, General & Internal WE Science Citation Index Expanded (SCI-EXPANDED) SC General & Internal Medicine GA W6V5J UT WOS:001419926300001 PM 39943720 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Fakhoury-Sayegh, N Younes, H Heraoui, GNHA Sayegh, R AF Fakhoury-Sayegh, Nicole Younes, Hassan Heraoui, Gessica N. H. A. Sayegh, Raymond TI Nutritional Profile and Dietary Patterns of Lebanese Non-Alcoholic Fatty Liver Disease Patients: A Case-Control Study SO NUTRIENTS LA English DT Article DE non-alcoholic fatty liver disease; high fruit group; high meat; fast food ID MEDITERRANEAN DIET; SWEETENED BEVERAGES; INSULIN SENSITIVITY; HEPATIC STEATOSIS; PHYSICAL-ACTIVITY; RISK; ACID; STEATOHEPATITIS; QUANTIFICATION; INDIVIDUALS AB Nonalcoholic fatty liver disease (NAFLD) is considered the most common liver disease in the world. Dietary habits have a significant impact on the biological and physical profile of patients and increase the risk of NAFLD. The overall pattern of diet intake is more associated with health outcomes than nutrients. The aim of this study was to evaluate the nutritional profile and the dietary patterns of Lebanese NAFLD patients and compare it with controls. During this study; 112 NAFLD Lebanese adult patients (55 men and 57 women); and 110 controls (44 men and 66 women) were recruited. Dietary intake was evaluated by two 24-h recalls and a semi-quantitative 90-item food frequency questionnaire. Dietary patterns were determined by factor analysis. Results from the study demonstrated that 40% of cases belonged to the high fruit group as compared to 30% following a high meat; fast food dietary pattern. Both groups increased the odds of NAFLD by four-fold (p < 0.05). The traditional diet decreases the odds by 33% after adjustment with the covariables. The high fruit diet group was, as with the high meat, fast food dietary pattern, the main potential risk factor for NAFLD in Lebanese patients. C1 [Fakhoury-Sayegh, Nicole; Heraoui, Gessica N. H. A.] St Joseph Univ, Fac Pharm, Dept Nutr, Damascus Rd,POB 11-5076, Beirut, Lebanon. [Younes, Hassan] Inst Polytech UniLaSalle, Dept Nutr & Hlth Sci, F-60026 Beauvais, France. [Sayegh, Raymond] St Joseph Univ, Dept Gastroenterol & Hepatol, Fac Med, Damascus Rd,POB 11-5076, Beirut, Lebanon. C3 UniLaSalle RP Fakhoury-Sayegh, N (通讯作者)，St Joseph Univ, Fac Pharm, Dept Nutr, Damascus Rd,POB 11-5076, Beirut, Lebanon. EM nicolesayegh@idm.net.lb; hassan.younes@unilasalle.fr; h.gessica10@gmail.com; rsayegh@usj.edu.lb RI Sayegh, Raymond/HLG-3023-2023 FU research council of Saint Joseph University, Beirut, Lebanon [FPH 34] FX This research (FPH 34) was supported by the research council of Saint Joseph University, Beirut, Lebanon. We thank them for their support. 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Several epidemiological studies attempted to assess the relationship between food groups and the likelihood of NAFLD, but these results were conflicting. The present meta-analysis was conducted to assess the association between food groups and the likelihood of NAFLD. Published literature was retrieved and screened from MEDLINE, Embase and Web of Science. Out of 7892 retrieved articles, twenty-four observational studies (fifteen cross-sectional studies and nine case-control studies) met our eligibility criteria and were finally included in this systematic review and meta-analysis. Consumption of both red meat and soft drinks contributed to a positive association with NAFLD. Inversely, nut consumption was negatively associated with NAFLD. There were no significant influences on the likelihood of NAFLD about consuming whole grains, refined grains, fish, fruits, vegetables, eggs, dairy products and legumes. 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J. Nutr. PD JUL 14 PY 2020 VL 124 IS 1 BP 1 EP 13 DI 10.1017/S0007114520000914 PG 13 WC Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Nutrition & Dietetics GA LX4JG UT WOS:000539798300001 PM 32138796 OA hybrid DA 2026-02-02 ER PT J AU Parker, A Kim, Y AF Parker, Aundrea Kim, Yeonsoo TI The Effect of Low Glycemic Index and Glycemic Load Diets on Hepatic Fat Mass, Insulin Resistance, and Blood Lipid Panels in Individuals with Nonalcoholic Fatty Liver Disease SO METABOLIC SYNDROME AND RELATED DISORDERS LA English DT Article DE glycemic index; glycemic load; nonalcoholic fatty liver disease; hepatic fat mass; ALT ID MEDITERRANEAN DIET; RISK-FACTORS; DIAGNOSIS AB Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease that is associated with insulin resistance and hepatic triglyceride accumulation. There is evidence to suggest that a low glycemic index (GI) diet can reduce glucose absorption, hepatic influx of glucose, and de novo lipogenesis. This review investigates the effect of low GI and glycemic load (GL) diets on hepatic fat mass, hepatic enzymes, insulin resistance, fasting blood glucose levels, and blood lipid panels in individuals with NAFLD. PubMed, Cumulative Index to Nursing and Allied Health Literature, and Web of Science were used in literature search. Search keywords included "glycemic index," "glycaemic index," "glycemic load," "glycaemic load," "nonalcoholic fatty liver disease," "NAFLD," "nonalcoholic steatohepatitis," and "NASH." Outcome measurements included hepatic fat mass, hepatic enzyme alanine transaminase (ALT), insulin resistance [homeostasis model assessment of insulin resistance (HOMA-IR)], fasting blood glucose levels, and/or blood lipid panels. Four eligible studies enrolling 281 individuals with NAFLD were included. Both hepatic fat mass and ALT showed significant reductions from baseline in both low GI and GL diets. One study showed no change, and another study showed significant reductions in HOMA-IR. No significant reduction in fasting blood glucose level, triglycerides, high-density lipoprotein-cholesterol, or low-density lipoprotein-cholesterol was observed from baseline in both low GI and GL diets. Findings from the review suggest that low GI and GL diets may reduce hepatic fat mass and ALT in individuals with NAFLD. Future research of large-scale, randomized controlled studies using isoenergetic, low GI and GL diets for long term is needed to draw conclusionary results. C1 [Parker, Aundrea; Kim, Yeonsoo] Cent Michigan Univ, Sch Rehabil & Med Sci Nutr & Dietet, Mt Pleasant, MI 48859 USA. C3 Central Michigan University RP Kim, Y (通讯作者)，Cent Michigan Univ, Dept Human Environm Studies Dietet & Nutr, 1202 South Washington St,207 Wightman Hall, Mt Pleasant, MI 48859 USA. EM kim7y@cmich.edu OI Parker, Aunea/0000-0003-4492-2114 CR Augustin LSA, 2015, NUTR METAB CARDIOVAS, V25, P795, DOI 10.1016/j.numecd.2015.05.005 Bawden S, 2017, DIABETES OBES METAB, V19, P70, DOI 10.1111/dom.12784 Bozzetto L, 2012, DIABETES CARE, V35, P1429, DOI 10.2337/dc12-0033 Buzzetti E, 2016, METABOLISM, V65, P1038, DOI 10.1016/j.metabol.2015.12.012 Chalasani NP, 2017, HEPATOLOGY, V66, p303A, DOI 10.1002/cld.722 Cheng GH, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-04787-2 Clar Christine, 2017, Cochrane Database Syst Rev, V7, pCD004467, DOI 10.1002/14651858.CD004467.pub3 Della Pepa G, 2017, NUTRIENTS, V9, DOI 10.3390/nu9101065 *EASLEASDEASO, 2016, J HEPATOL, V64, P1388 Fraser A, 2008, DIABETOLOGIA, V51, P1616, DOI 10.1007/s00125-008-1049-1 Kabisch M, 2011, DTSCH ARZTEBL INT, V108, P663, DOI 10.3238/arztebl.2011.0663 Mager DR, 2015, JPEN-PARENTER ENTER, V39, P73, DOI 10.1177/0148607113501201 Mandal A, 2018, CUREUS J MED SCIENCE, V10, DOI 10.7759/cureus.3626 Misciagna G, 2017, J NUTR HEALTH AGING, V21, P404, DOI 10.1007/s12603-016-0809-8 Monro JA, 2008, AM J CLIN NUTR, V87, p237S, DOI 10.1093/ajcn/87.1.237S *NAT HEART LUNG BL, STUD QUAL ASS TOOLS Pereira MA, 2004, JAMA-J AM MED ASSOC, V292, P2482, DOI 10.1001/jama.292.20.2482 Perumpail Brandon J, 2017, Diseases, V5, DOI [10.3390/diseases5040023, 10.3390/diseases5040023] *PRISMA, 2015, PRISMA SYST REV PROT Ramon-Krauel M, 2013, CHILD OBES, V9, P252, DOI 10.1089/chi.2013.0022 Rinella ME, 2015, JAMA-J AM MED ASSOC, V313, P2263, DOI 10.1001/jama.2015.5370 Spengler EK, 2015, MAYO CLIN PROC, V90, P1233, DOI 10.1016/j.mayocp.2015.06.013 Utzschneider KM, 2013, BRIT J NUTR, V109, P1096, DOI 10.1017/S0007114512002966 Valtueña S, 2006, AM J CLIN NUTR, V84, P136, DOI 10.1093/ajcn/84.1.136 Visuthranukul C, 2015, PEDIATR RES, V78, P567, DOI 10.1038/pr.2015.142 Wong VWS, 2013, J HEPATOL, V59, P536, DOI 10.1016/j.jhep.2013.04.013 Yki-Järvinen H, 2016, DIABETOLOGIA, V59, P1104, DOI 10.1007/s00125-016-3944-1 Younossi ZM, 2018, CLIN LIVER DIS, V22, P1, DOI 10.1016/j.cld.2017.08.001 Younossi ZM, 2015, HEPATOLOGY, V62, p739A, DOI 10.1002/hep.28431 2017, DIG LIVER DIS, V49, P471 NR 30 TC 26 Z9 31 U1 0 U2 11 PU MARY ANN LIEBERT, INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1540-4196 EI 1557-8518 J9 METAB SYNDR RELAT D JI Metab. Syndr. Relat. Disord. PD OCT 1 PY 2019 VL 17 IS 8 BP 389 EP 396 DI 10.1089/met.2019.0038 EA JUL 2019 PG 8 WC Medicine, Research & Experimental WE Science Citation Index Expanded (SCI-EXPANDED) SC Research & Experimental Medicine GA JB3ZI UT WOS:000476171600001 PM 31305201 DA 2026-02-02 ER PT J AU Mayr, HL Kelly, JT Macdonald, GA Hickman, IJ AF Mayr, Hannah L. Kelly, Jaimon T. Macdonald, Graeme A. Hickman, Ingrid J. TI 'Focus on diet quality': a qualitative study of clinicians' perspectives of use of the Mediterranean dietary pattern for non-alcoholic fatty liver disease SO BRITISH JOURNAL OF NUTRITION LA English DT Article DE Mediterranean diet; Dietary pattern; Metabolic liver disease; Qualitative research; Knowledge translation ID MANAGEMENT; ADHERENCE; NUTRITION; EDUCATION; SERVICES AB Practice guidelines for non-alcoholic fatty liver disease (NAFLD) recommend promoting the Mediterranean dietary pattern (MDP) which is cardioprotective and may improve hepatic steatosis. This study aimed to explore multidisciplinary clinicians' perspectives on whether the MDP is recommended in routine management of NAFLD and barriers and facilitators to its implementation in a multi-ethnic setting. Semi-structured individual interviews were conducted with fourteen clinicians (seven doctors, three nurses, three dietitians and one exercise physiologist) routinely managing patients with NAFLD in metropolitan hospital outpatient clinics in Australia. Interviews were audio-recorded, transcribed and analysed using thematic content analysis. Clinicians described that lifestyle modification was their primary treatment for NAFLD and promoting diet was recognised as everyone's role, whereby doctors and nurses raise awareness and dietitians provide individualisation. The MDP was regarded as the most evidence-based diet choice currently and was frequently recommended in routine care. Facilitators to MDP implementation in practice were: improvement in diet quality as a parallel goal to weight loss; in-depth knowledge of the dietary pattern; access to patient education and monitoring resources and; service culture, including an interdisciplinary clinic goal, and knowledge sharing from expert dietitians. Barriers included perceived challenges for patients from diverse cultural and socio-economic backgrounds and limited clinician training, time and resourcing to support behaviour change. Integration of MDP in routine management of NAFLD in specialist clinics was facilitated by a focus on diet quality, knowledge sharing, belief in evidence and an interdisciplinary team. Innovations to service delivery could better support and empower patients to change dietary behaviour long-term. C1 [Mayr, Hannah L.; Hickman, Ingrid J.] Princess Alexandra Hosp, Nutr & Dietet Dept, Brisbane, Qld, Australia. [Mayr, Hannah L.] Bond Univ, Nutr & Dietet Res Grp, Fac Hlth Sci & Med, Gold Coast, Qld, Australia. [Mayr, Hannah L.; Macdonald, Graeme A.; Hickman, Ingrid J.] Univ Queensland, Fac Med, Brisbane, Qld, Australia. [Kelly, Jaimon T.] Griffith Univ, Menzies Hlth Inst Queensland, Gold Coast, Qld, Australia. [Kelly, Jaimon T.] Griffith Univ, Ctr Appl Hlth Econ, Brisbane, Qld, Australia. [Macdonald, Graeme A.] Princess Alexandra Hosp, Dept Gastroenterol & Hepatol, Brisbane, Qld, Australia. C3 Princess Alexandra Hospital; Bond University; University of Queensland; Menzies Health Institute Queensland; Griffith University; Griffith University; Princess Alexandra Hospital RP Mayr, HL (通讯作者)，Princess Alexandra Hosp, Nutr & Dietet Dept, Brisbane, Qld, Australia.; Mayr, HL (通讯作者)，Bond Univ, Nutr & Dietet Res Grp, Fac Hlth Sci & Med, Gold Coast, Qld, Australia.; Mayr, HL (通讯作者)，Univ Queensland, Fac Med, Brisbane, Qld, Australia. EM hannah.mayr@health.qld.gov.au RI ; Macdonald, Graeme A/K-4167-2013; Hickman, Ingrid J/P-8364-2016; Kelly, Jaimon/GNP-3057-2022 OI Mayr, Hannah L/0000-0001-7356-653X; Macdonald, Graeme A/0000-0003-0929-110X; Hickman, Ingrid J/0000-0003-3205-9165; Kelly, Jaimon/0000-0003-0232-5848 FU Metro South Health's Study, Education and Research Trust Account (SERTA) Early Career Research Grant; Griffith University Postdoctoral Research Fellowship; Cobram Estate Pty. Ltd. FX The authors thank A/Prof Katrina Campbell, Dr Michelle Palmer and Dr Shelley Keating for their methodological support. H. L. M. and this study were supported by a Metro South Health's Study, Education and Research Trust Account (SERTA) Early Career Research Grant. J. T. K. is supported through a Griffith University Postdoctoral Research Fellowship. Authors have no relevant conflicts of interest to disclose related to the current study. H. L. M. is an investigator on a clinical trial independent to the current study which received financial support from Cobram Estate Pty. Ltd. 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J. Nutr. PD OCT 14 PY 2022 VL 128 IS 7 SI SI BP 1220 EP 1230 AR PII S0007114521001100 DI 10.1017/S0007114521001100 EA MAR 2021 PG 11 WC Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Nutrition & Dietetics GA 5A5AG UT WOS:000744725400001 PM 33766176 OA Green Submitted, Bronze DA 2026-02-02 ER PT J AU Varkaneh, HK Poursoleiman, F Al Masri, MK Alras, KA Shayah, Y Masmoum, MD Alangari, FA Alras, A Rinaldi, G Day, AS Hekmatdoost, A Abu-Zaid, A Kutbi, E AF Varkaneh, Hamed Kord Poursoleiman, Faezeh Al Masri, Mohammad Khaldoun Alras, Kamar Allayl Shayah, Yamen Masmoum, Mohd Diya Alangari, Fulwah Abdulaziz Alras, Abd Alfatah Rinaldi, Giulia Day, Andrew S. S. Hekmatdoost, Azita Abu-Zaid, Ahmed Kutbi, Emad TI Low fat diet versus low carbohydrate diet for management of non-alcohol fatty liver disease: A systematic review SO FRONTIERS IN NUTRITION LA English DT Review DE non-alcoholic fatty liver disease; low fat diet; low carbohydrate diet; NAFLD; liver fat ID LIFE-STYLE MODIFICATION; WEIGHT-LOSS; HEPATIC STEATOSIS; AMINOTRANSFERASE LEVELS; MEDITERRANEAN DIET; OBESE; RESTRICTION; REDUCTION; DECREASE; ADULTS AB Although there is a consensus on beneficial effects of a low calorie diet in management of non-alcoholic fatty liver disease, the optimal composition of diet has not yet been elucidated. The aim of this review is to summarize the results of current randomized controlled trials evaluating the effects of low fat diet (LFD) vs. low carbohydrate diet (LCD) on NAFLD. This is a systematic review of all the available data reported in published clinical trials up to February 2022. The methodological quality of eligible studies was assessed, and data were presented aiming specific standard measurements. A total of 15 clinical trial studies were included in this systematic review. There is an overall lack of consensus on which dietary intervention is the most beneficial for NAFLD patients. There is also an overall lack of consensus on the definition of the different restrictive diets and the percentage of macronutrient restriction recommended. It seems that low calorie diets, regardless of their fat and carbohydrate composition, are efficient for liver enzyme reduction. Both LCD and LFD have similar effects on liver enzymes change; however, this improvement tends to be more marked in LFD. All calorie restrictive dietary interventions are beneficial for reducing weight, liver fat content and liver enzymes in individuals with NAFLD. Low fat diets seem to be markedly successful in reducing transaminase levels. Further research is needed to explore diet intensity, duration and long-term outcome. C1 [Varkaneh, Hamed Kord; Poursoleiman, Faezeh; Hekmatdoost, Azita] Shahid Beheshti Univ Med Sci, Student Res Comm, Fac Nutr & Food Technol, Dept Clin Nutr & Dietet, Tehran, Iran. [Al Masri, Mohammad Khaldoun; Alras, Kamar Allayl; Shayah, Yamen; Masmoum, Mohd Diya; Alangari, Fulwah Abdulaziz; Abu-Zaid, Ahmed] Alfaisal Univ, Coll Med, Riyadh, Saudi Arabia. [Alras, Abd Alfatah] Univ Saskatchewan, Coll Kinesiol, Saskatoon, SK, Canada. [Rinaldi, Giulia] St George Hosp, London, England. [Day, Andrew S. S.] Univ Otago, Dept Paediat, Dunedin, New Zealand. [Abu-Zaid, Ahmed] Univ Tennessee, Coll Grad Hlth Sci, Dept Pharmacol, Hlth Sci Ctr, Memphis, TN 38163 USA. [Kutbi, Emad] King Fahad Med City, Dept Biorepository, Biomed Res Adm, Riyadh, Saudi Arabia. C3 Shahid Beheshti University Medical Sciences; Alfaisal University; University of Saskatchewan; City St Georges, University of London; University of Otago; University of Tennessee System; University of Tennessee Health Science Center; King Fahad Medical City RP Hekmatdoost, A (通讯作者)，Shahid Beheshti Univ Med Sci, Student Res Comm, Fac Nutr & Food Technol, Dept Clin Nutr & Dietet, Tehran, Iran.; Abu-Zaid, A (通讯作者)，Alfaisal Univ, Coll Med, Riyadh, Saudi Arabia.; Abu-Zaid, A (通讯作者)，Univ Tennessee, Coll Grad Hlth Sci, Dept Pharmacol, Hlth Sci Ctr, Memphis, TN 38163 USA. EM a_hekmat2000@yahoo.com; aabuzaid@live.com RI Abu-Zaid, Ahmed/JHS-7565-2023; Hekmatdoost, Azita/AGM-6497-2022; Kord Varkaneh, Hamed/AGF-1347-2022 OI Abu-Zaid, Ahmed/0000-0003-2286-2181; FU Student Research Committee, Shahid Beheshti University of Medical Sciences (SBMU), Tehran, Iran; [1398/9924] FX This study was supported by grants from the Student Research Committee, Shahid Beheshti University of Medical Sciences (SBMU), Tehran, Iran (Grant's ID: 1398/9924). 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Nutr. PD AUG 16 PY 2022 VL 9 AR 987921 DI 10.3389/fnut.2022.987921 PG 11 WC Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Nutrition & Dietetics GA 4F2MZ UT WOS:000848351400001 PM 36051903 OA Green Submitted, gold DA 2026-02-02 ER PT J AU El-Agroudy, NN Kurzbach, A Rodionov, RN O'Sullivan, J Roden, M Birkenfeld, AL Pesta, DH AF El-Agroudy, Nermeen N. Kurzbach, Anica Rodionov, Roman N. O'Sullivan, John Roden, Michael Birkenfeld, Andreas L. Pesta, Dominik H. TI Are Lifestyle Therapies Effective for NAFLD Treatment? SO TRENDS IN ENDOCRINOLOGY AND METABOLISM LA English DT Review ID FATTY-LIVER-DISEASE; INTRAHEPATIC LIPID-CONTENT; FRUCTOSE CORN SYRUP; MEDITERRANEAN DIET; HEPATIC STEATOSIS; INSULIN SENSITIVITY; PHYSICAL-ACTIVITY; WEIGHT-LOSS; EXERCISE; RESISTANCE AB Nonalcoholic fatty liver disease (NAFLD) is becoming the most common liver disorder worldwide. Specifically, nonalcoholic steatohepatitis (NASH) and fibrosis pose an enormous burden for patients and health-care systems. In the absence of approved pharmacological therapies effective lifestyle interventions for NAFLD, such as dietary strategies and exercise training are currently the therapeutic strategies of choice. This review covers the influence of macro-nutrient quality and quantity (i.e., low-carbohydrate and high-protein diets), for successful reduction of intrahepatocellular lipids (IHL). Moreover, we discuss the effectiveness of different modalities of physical exercising with and without weight loss. These lifestyle modifications not only provide strategies to reduce IHL but may also hold a still underestimatec potential to induce improvement and/or even remission of NAFLD. C1 [El-Agroudy, Nermeen N.; Kurzbach, Anica; Rodionov, Roman N.; O'Sullivan, John; Birkenfeld, Andreas L.] Tech Univ Dresden, Univ klinikum Carl Gustav Carus, Med Klin 3, Dresden, Germany. [O'Sullivan, John] Univ Sydney, Charles Perkins Ctr, Sydney, NSW, Australia. [Roden, Michael] Heinrich Heine Univ Dusseldorf, Med Fac, Div Endocrinol & Diabetol, Dusseldorf, Germany. [Roden, Michael; Pesta, Dominik H.] Heinrich Heine Univ Dusseldorf, German Diabet Ctr, Inst Clin Diabetol, Dusseldorf, Germany. [Roden, Michael; Pesta, Dominik H.] Heinrich Heine Univ Dusseldorf, Leibniz Ctr Diabet Res, German Diabet Ctr, Dusseldorf, Germany. [El-Agroudy, Nermeen N.; Kurzbach, Anica; Roden, Michael; Birkenfeld, Andreas L.; Pesta, Dominik H.] German Ctr Diabet Res DZD eV, Munich, Germany. [Birkenfeld, Andreas L.] Kings Coll London, Rayne Inst, Sect Diabet & Nutr Sci, Denmark Hill Campus, London, England. [Birkenfeld, Andreas L.] Tech Univ Dresden, Helmholtz Zentrum Munchen, Paul Langerhans Inst Dresden, Dresden, Germany. C3 Technische Universitat Dresden; Carl Gustav Carus University Hospital; University of Sydney; Heinrich Heine University Dusseldorf; Heinrich Heine University Dusseldorf; Leibniz Association; Deutsches Diabetes-Zentrum (DDZ); Heinrich Heine University Dusseldorf; Leibniz Association; Deutsches Diabetes-Zentrum (DDZ); German Center for Diabetes Research (DZD); University of London; King's College London; Helmholtz Association; Helmholtz-Center Munich - German Research Center for Environmental Health; Technische Universitat Dresden RP Birkenfeld, AL (通讯作者)，Tech Univ Dresden, Univ klinikum Carl Gustav Carus, Med Klin 3, Dresden, Germany.; Birkenfeld, AL (通讯作者)，German Ctr Diabet Res DZD eV, Munich, Germany.; Birkenfeld, AL (通讯作者)，Kings Coll London, Rayne Inst, Sect Diabet & Nutr Sci, Denmark Hill Campus, London, England.; Birkenfeld, AL (通讯作者)，Tech Univ Dresden, Helmholtz Zentrum Munchen, Paul Langerhans Inst Dresden, Dresden, Germany. EM Andreas.birkenfeld@uniklinikum-dresden.de RI Roden, Michael/AAD-3843-2019; Birkenfeld, Aneas/U-3954-2019; O'Sullivan, John/HLQ-3191-2023; Pesta, Dominik/AAV-7108-2020 OI Roden, Michael/0000-0001-8200-6382; Birkenfeld, Aneas/0000-0003-1407-9023; O'Sullivan, John/0000-0001-8016-5128; Pesta, Dominik/0000-0002-5089-3586; Kurzbach, Anica/0000-0003-1531-3088 CR Abdelbasset WK, 2019, MEDICINE, V98, DOI [10.1097/md.0000000000014918, 10.1097/MD.0000000000014918] Bacchi E, 2013, HEPATOLOGY, V58, P1287, DOI 10.1002/hep.26393 Bo S, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0108467 Boden G, 2015, SCI TRANSL MED, V7, DOI 10.1126/scitranslmed.aac4765 Brouwers B, 2018, AM J PHYSIOL-ENDOC M, V314, pE165, DOI 10.1152/ajpendo.00266.2017 Brouwers B, 2016, DIABETOLOGIA, V59, P2068, DOI 10.1007/s00125-016-4037-x Cantero I, 2017, NUTRIENTS, V9, DOI 10.3390/nu9070667 Chen JP, 2018, NUTRIENTS, V10, DOI 10.3390/nu10010024 Cheng SL, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-16159-x Ibarra-Reynoso LD, 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Metab. PD OCT PY 2019 VL 30 IS 10 BP 701 EP 709 DI 10.1016/j.tem.2019.07.013 PG 9 WC Endocrinology & Metabolism WE Science Citation Index Expanded (SCI-EXPANDED) SC Endocrinology & Metabolism GA JC1CE UT WOS:000489015300005 PM 31422872 OA Bronze DA 2026-02-02 ER PT J AU Coronati, M Baratta, F Pastori, D Ferro, D Angelico, F Del Ben, M AF Coronati, Mattia Baratta, Francesco Pastori, Daniele Ferro, Domenico Angelico, Francesco Del Ben, Maria TI Added Fructose in Non-Alcoholic Fatty Liver Disease and in Metabolic Syndrome: A Narrative Review SO NUTRIENTS LA English DT Article DE NAFLD; metabolic syndrome; fructose; HFCS ID SUGAR-SWEETENED BEVERAGES; HEALTHY-YOUNG MEN; CORN SYRUP; INSULIN-RESISTANCE; MEDITERRANEAN DIET; MODERATE AMOUNTS; CONSUMPTION; WEIGHT; SUCROSE; ACID AB Non-alcoholic fatty liver disease (NAFLD) represents the most common chronic liver disease and it is considered the hepatic manifestation of metabolic syndrome (MetS). Diet represents the key element in NAFLD and MetS treatment, but some nutrients could play a role in their pathophysiology. Among these, fructose added to foods via high fructose corn syrup (HFCS) and sucrose might participate in NAFLD and MetS onset and progression. Fructose induces de novo lipogenesis (DNL), endoplasmic reticulum stress and liver inflammation, promoting insulin resistance and dyslipidemia. Fructose also reduces fatty acids oxidation through the overproduction of malonyl CoA, favoring steatosis. Furthermore, recent studies suggest changes in intestinal permeability associated with fructose consumption that contribute to the risk of NAFLD and MetS. Finally, alterations in the hunger-satiety mechanism and in the synthesis of uric acid link the fructose intake to weight gain and hypertension, respectively. However, further studies are needed to better evaluate the causal relationship between fructose and metabolic diseases and to develop new therapeutic and preventive strategies against NAFLD and MetS. C1 [Coronati, Mattia; Baratta, Francesco; Pastori, Daniele; Ferro, Domenico; Del Ben, Maria] Sapienza Univ Rome, Dept Clin Internal Anesthesiol & Cardiovasc Sci, Clin Med 1, I-00161 Rome, Italy. [Angelico, Francesco] Sapienza Univ Rome, Dept Publ Hlth & Infect Dis, I-00161 Rome, Italy. C3 Sapienza University Rome; Sapienza University Rome RP Baratta, F (通讯作者)，Sapienza Univ Rome, Dept Clin Internal Anesthesiol & Cardiovasc Sci, Clin Med 1, I-00161 Rome, Italy. 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NATURE, V579, P586, DOI 10.1038/s41586-020-2101-7 NR 77 TC 40 Z9 49 U1 1 U2 24 PU MDPI PI BASEL PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND EI 2072-6643 J9 NUTRIENTS JI Nutrients PD MAR PY 2022 VL 14 IS 6 AR 1127 DI 10.3390/nu14061127 PG 10 WC Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Nutrition & Dietetics GA 0B4RD UT WOS:000774623000001 PM 35334784 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Brunner, KT Henneberg, CJ Wilechansky, RM Long, MT AF Brunner, Katherine T. Henneberg, Cameron J. Wilechansky, Robert M. Long, Michelle T. TI Nonalcoholic Fatty Liver Disease and Obesity Treatment SO CURRENT OBESITY REPORTS LA English DT Article DE Nonalcoholic fatty liver disease; Nonalcoholic steatohepatitis; Obesity; Diabetes; Body mass index; Magnetic resonance elastography; NAFLD activity score; Intrahepatic triglycerides; Bariatric surgery ID Y GASTRIC BYPASS; LIFE-STYLE MODIFICATION; MEDITERRANEAN DIET; SLEEVE GASTRECTOMY; VITAMIN-E; CARDIOVASCULAR-DISEASE; HISTOLOGIC FEATURES; HEPATIC STEATOSIS; AEROBIC EXERCISE; GLYCEMIC INDEX AB Purpose of ReviewNonalcoholic fatty liver disease (NAFLD), the most prevalent cause of chronic liver disease worldwide, is strongly associated with obesity and insulin resistance.Recent FindingsSignificant weight loss can improve NAFLD and nonalcoholic steatohepatitis (NASH). Diet and exercise that result in a sustained body weight reduction of 7-10% can improve liver fat content, NASH, and fibrosis. Vitamin E can be considered in patients with biopsy-proven NASH without diabetes, though caution must be used in those with prostate cancer. Pioglitazone improves liver histology, including fibrosis, and can be considered in patients with or without diabetes. Glucagon-like peptide-1 (GLP-1) antagonists may be beneficial in NASH, but more studies are needed before they can be recommended. Bariatric surgery, with resultant weight loss, can result in improvement in liver fat and inflammation.SummaryNAFLD treatment includes diet and exercise with a target 7-10% weight reduction. Treatment goals include improvements in liver fat content, liver inflammation, and fibrosis. C1 [Brunner, Katherine T.; Long, Michelle T.] Boston Univ, Sch Med, Boston Med Ctr, Gastroenterol Sect, 85 East Concord St 7th Floor, Boston, MA 02118 USA. [Henneberg, Cameron J.] Boston Univ, Sch Med, Boston, MA 02118 USA. [Wilechansky, Robert M.] Boston Univ, Sch Med, Evans Dept Med, Boston Med Ctr, Boston, MA 02118 USA. C3 Boston Medical Center; Boston University; Boston University; Boston Medical Center; Boston University RP Long, MT (通讯作者)，Boston Univ, Sch Med, Boston Med Ctr, Gastroenterol Sect, 85 East Concord St 7th Floor, Boston, MA 02118 USA. EM Katherine.brunner@bmc.org; cameronhenneberg@gmail.com; Robert.wilechansky@bmc.org; mtlong@bu.edu RI Long, Michelle/H-3801-2019 OI Wilechansky, Robert/0000-0003-4593-7684 FU National Institute of Diabetes and Digestive and Kidney Diseases [K23 DK113252]; Boston University School of Medicine Department of Medicine Career Investment Award; Boston University Clinical Translational Science Institute [UL1 TR001430]; National Center for Advancing Translational Sciences [UL1TR001430] Funding Source: NIH RePORTER; National Institute of Diabetes and Digestive and Kidney Diseases [K23DK113252] Funding Source: NIH RePORTER FX Dr. Long is supported in part by the National Institute of Diabetes and Digestive and Kidney Diseases K23 DK113252, the Boston University School of Medicine Department of Medicine Career Investment Award, and the Boston University Clinical Translational Science Institute UL1 TR001430. 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Obes. Rep. PD SEP PY 2019 VL 8 IS 3 BP 220 EP 228 DI 10.1007/s13679-019-00345-1 PG 9 WC Endocrinology & Metabolism; Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Endocrinology & Metabolism; Nutrition & Dietetics GA IL9XI UT WOS:000477637900003 PM 30945129 OA Green Submitted DA 2026-02-02 ER PT J AU Marchesini, G Petta, S Dalle Grave, R AF Marchesini, Giulio Petta, Salvatore Dalle Grave, Riccardo TI Diet, Weight Loss, and Liver Health in Nonalcoholic Fatty Liver Disease: Pathophysiology, Evidence, and Practice SO HEPATOLOGY LA English DT Review ID LIFE-STYLE INTERVENTION; PHYSICAL-ACTIVITY; HEPATIC STEATOSIS; CARDIORESPIRATORY FITNESS; BEHAVIORAL TREATMENT; AMERICAN-COLLEGE; UNITED-STATES; OBESE; EXERCISE; NAFLD AB Fatty liver accumulation results from an imbalance between lipid deposition and removal, driven by the hepatic synthesis of triglycerides and de novo lipogenesis. The habitual diet plays a relevant role in the pathogenesis of nonalcoholic fatty liver disease (NAFLD), and both risky (e.g., fructose) and protective foods (Mediterranean diet) have been described, but the contribution of excess calories remains pivotal. Accordingly, weight loss is the most effective way to promote liver fat removal. Several controlled studies have confirmed that an intense approach to lifestyle changes, carried on along the lines of cognitive-behavior treatment, is able to attain the desired 7%-10% weight loss, associated with reduced liver fat, nonalcoholic steatohepatitis (NASH) remission, and also reduction of fibrosis. Even larger effects are reported after bariatric surgery-induced weight loss in NAFLD, where 80% of subjects achieve NASH resolution at 1-year follow-up. These results provide solid data to evaluate the safety and effectiveness of the pharmacological treatment of NASH. The battle against metabolic diseases, largely fueled by increased liver fat, needs a comprehensive approach to be successful in an obesiogenic environment. In this review, we will discuss the role of hepatic lipid metabolism, genetic background, diet, and physical activity on fatty liver. They are the basis for a lifestyle approach to NAFLD treatment. C1 [Marchesini, Giulio] Alma Mater Studiorum Univ, Unit Metab Dis & Clin Dietet, 9 Via Massarenti, I-40138 Bologna, Italy. [Petta, Salvatore] Univ Palermo, Gastroenterol Sect, DiBiMIS, Palermo, Italy. [Dalle Grave, Riccardo] Villa Garda Hosp, Dept Eating & Weight Disorders, Garda, VR, Italy. C3 University of Bologna; University of Palermo RP Marchesini, G (通讯作者)，Alma Mater Studiorum Univ, Unit Metab Dis & Clin Dietet, 9 Via Massarenti, I-40138 Bologna, Italy. 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Quetglas-Llabrés, MM Monserrat-Mesquida, M Bouzas, C García, S Mateos, D Casares, M Gómez, C Ugarriza, L Tur, JA Sureda, A AF Quetglas-Llabres, Maria Magdalena Monserrat-Mesquida, Margalida Bouzas, Cristina Garcia, Silvia Mateos, David Casares, Miguel Gomez, Cristina Ugarriza, Lucia Tur, Josep A. Sureda, Antoni TI Effects of a Two-Year Lifestyle Intervention on Intrahepatic Fat Reduction and Renal Health: Mitigation of Inflammation and Oxidative Stress, a Randomized Trial SO ANTIOXIDANTS LA English DT Article DE MAFLD; renal dysfunction; intrahepatic fat content; lifestyle change; oxidative state; inflammation; intervention; fatty liver ID CHRONIC KIDNEY-DISEASE; LIVER-DISEASE; CARDIOVASCULAR-DISEASE; RISK; OBESITY; HYPERFILTRATION; ASSOCIATION; EQUATION; VALIDITY; DIET AB Metabolic-associated fatty liver disease (MAFLD) is the most common chronic liver disease observed in clinical practice worldwide. This disorder has been independently associated with an increased risk of developing chronic kidney disease (CKD). The aim of this study was to evaluate whether a 2-year intervention based on a Mediterranean diet (MedDiet) and physical activity focussed on reducing intrahepatic fat contents (IFC) was associated with a decreased risk of CKD. Forty adults (50% women) residing in Mallorca, aged 48 to 60 years, diagnosed with MAFLD were recruited. Participants were divided into two groups based on whether they improved IFC measured by nuclear magnetic resonance. Anthropometric and clinical parameters improved in responders, including reduced weight, body mass index (BMI), and waist circumference. Only responders showed improvements in lipid profile and liver enzymes. Haematological parameters showed favourable changes in both groups. Oxidative stress and inflammatory biomarkers differed between groups. Responders had lower plasma interleukine-18 (IL-18) levels, but higher erythrocyte malonaldehyde (MDA) levels. Non-responders showed increased erythrocyte catalase and superoxide dismutase activity. After 2 years, non-responders had higher serum creatinine, Modification of Diet in Renal Disease (MDRD), and Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) levels, while responders showed reductions in these parameters together with uric acid and urine albumin-to-creatinine ratio (UACR). Positive correlations were found between changes in IFC and kidney injury biomarkers, including MDRD and serum creatinine levels. In conclusion, a healthy diet based on the Mediterranean dietary pattern and lifestyle promotes significant improvements in parameters related to cardiovascular, hepatic, and renal health. C1 [Quetglas-Llabres, Maria Magdalena; Monserrat-Mesquida, Margalida; Bouzas, Cristina; Garcia, Silvia; Mateos, David; Ugarriza, Lucia; Tur, Josep A.; Sureda, Antoni] Inst Salud Carlos III, Ctr Invest Biomed Red Fisiopatol Obes & Nutr CIBER, Madrid 28029, Spain. [Quetglas-Llabres, Maria Magdalena; Monserrat-Mesquida, Margalida; Bouzas, Cristina; Garcia, Silvia; Mateos, David; Gomez, Cristina; Ugarriza, Lucia; Tur, Josep A.; Sureda, Antoni] Univ Balear Islands IUNICS, Res Grp Community Nutr & Oxidat Stress, Palma De Mallorca 07120, Spain. [Quetglas-Llabres, Maria Magdalena; Monserrat-Mesquida, Margalida; Bouzas, Cristina; Garcia, Silvia; Mateos, David; Gomez, Cristina; Ugarriza, Lucia; Tur, Josep A.; Sureda, Antoni] Hlth Res Inst Balear Islands IdISBa, Palma De Mallorca 07120, Spain. [Casares, Miguel] Red Asistencial Juaneda, Radiodiag Serv, Palma De Mallorca 07011, Spain. [Gomez, Cristina] Univ Hosp Son Espases, Clin Anal Serv, Palma De Mallorca 07198, Spain. [Ugarriza, Lucia] IBSalut, CS Camp Redo, Palma De Mallorca 07010, Spain. C3 Instituto de Salud Carlos III; Hospital Universitari Son Espases RP Tur, JA (通讯作者)，Inst Salud Carlos III, Ctr Invest Biomed Red Fisiopatol Obes & Nutr CIBER, Madrid 28029, Spain.; Tur, JA (通讯作者)，Univ Balear Islands IUNICS, Res Grp Community Nutr & Oxidat Stress, Palma De Mallorca 07120, Spain.; Tur, JA (通讯作者)，Hlth Res Inst Balear Islands IdISBa, Palma De Mallorca 07120, Spain. EM m.quetglas@uib.es; margalida.monserrat@uib.es; cristina.bouzas@uib.es; silvia.garcia@uib.es; davidfrom13@gmail.com; casaresmiguel@gmail.com; cristina.gomez@ssib.es; luciaugarriza@gmail.com; pep.tur@uib.es; antoni.sureda@uib.es RI ; Tur, Josep/AAE-5748-2020; Monserrat Mesquida, Margalida/AAB-4773-2019; Quetglas Llabrés, Maria Magdalena/AAA-4412-2019; Bouzas, Cristina/AAE-2069-2019; Sureda, Antoni/N-9588-2019 OI Bouzas Velasco, Cristina/0000-0002-1407-8461; Tur, Josep/0000-0002-6940-0761; Monserrat Mesquida, Margalida/0000-0002-8856-135X; , Antoni/0000-0001-8656-6838; GOMEZ COBO, CRISTINA/0000-0002-9776-4730; García, Silvia/0000-0003-3534-1588; Quetglas Llabrés, Maria Magdalena/0000-0003-4155-7780; FU FundacioLa MaratoTV3 (Spain) [201630.10]; Instituto de Salud Carlos III through the Fondo de Investigacion para la Salud [CIBEROBNCB12/03/30038]; European Regional Development Fund; IDISBA Grants (FOLIUM, PRIMUS, SYNERGIA, and LIBERI); JUNIOR-IDISBA predoctoral grant FX Funding was provided for FundacioLa MaratoTV3 (Spain) project ref. 201630.10.by Instituto de Salud Carlos III through the Fondo de Investigacion para la Salud (CIBEROBNCB12/03/30038), which is cofunded by the European Regional Development Fund. Funding wasalso obtained through IDISBA Grants (FOLIUM, PRIMUS, SYNERGIA, and LIBERI). M.Q.-LL. was granted by the JUNIOR-IDISBA predoctoral grant. The funding sponsors had no role in the designof the study; in the collection, analyses, or interpretation of the data; in the writing of the manuscript;or in the decision to publish the results. 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Chemistry, Medicinal; Food Science & Technology WE Science Citation Index Expanded (SCI-EXPANDED) SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science & Technology GA A3M8R UT WOS:001281615000001 PM 39061823 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Shanmugam, H Di Ciaula, A Di Palo, DM Molina-Molina, E Garruti, G Faienza, MF VanErpecum, K Portincasa, P AF Shanmugam, Harshitha Di Ciaula, Agostino Di Palo, Domenica Maria Molina-Molina, Emilio Garruti, Gabriella Faienza, Maria Felicia VanErpecum, Karel Portincasa, Piero TI Multiplying effects of COVID-19 lockdown on metabolic risk and fatty liver SO EUROPEAN JOURNAL OF CLINICAL INVESTIGATION LA English DT Article DE bariatric surgery; body mass index; COVID-19 pandemic; lifestyles; lockdown; Mediterranean diet; metabolic syndrome; NAFLD; nonalcoholic fatty liver disease; obesity; physical activity; weight gain ID LIFE-STYLE CHANGES; PHYSICAL-ACTIVITY; NATURAL-HISTORY; EATING HABITS; WEIGHT-GAIN; CONFINEMENT; DISEASE; EPIDEMIOLOGY; DETERMINANTS; PREVALENCE AB Background Social containment measures imposed in Europe during the lockdown to face COVID-19 pandemic can generate long-term potential threats for metabolic health. Methods A cohort of 494 non-COVID-19 subjects living in 21 EU countries were interviewed by an anonymous questionnaire exploring anthropometric and lifestyle changes during 1-month lockdown. A subgroup of 41 overweight/obese Italian subjects with previously diagnosed nonalcoholic fatty liver (NAFLD) joined the study following a 12-month follow-up period promoting weight loss by healthy lifestyle. Results During the lockdown, body weight increased in 55% of subjects (average 2.4 +/- 0.9 kg). Weight change increased with age, but not baseline body mass index. Subjects living in Italy had greater weight gain than those living in other European Countries. Weight gain during the lockdown was highest in subjects reporting no physical activity, and low adherence to Mediterranean diet. In the NAFLD group, weight gain occurred in 70% of cases. Subjects reporting weight loss during lockdown had decreased fatty liver score at 3 months before the lockdown, as compared with 1 year before. Conclusions Strict measures of social containment-even short-term-pave the way to the increased risk of metabolic abnormalities in the medium-long term. In this context, adherence to Mediterranean diet and regular physical activity play a protective role both in terms of weight gain and fatty liver development/progression, with implication for primary and secondary prevention. When adopting measures imposing social containment, intensive educational campaigns must increase public awareness about beneficial effects of healthy lifestyles. C1 [Shanmugam, Harshitha; Di Ciaula, Agostino; Di Palo, Domenica Maria; Molina-Molina, Emilio; Portincasa, Piero] Univ Bari Aldo Moro, Dept Biomed Sci & Human Oncol, Clin Med A Murri, Bari, Italy. [Garruti, Gabriella] Univ Bari Aldo Moro, Dept Emergency & Organ Transplantat, Sect Endocrinol, Sch Med, Bari, Italy. [Faienza, Maria Felicia] Univ Bari Aldo Moro, Dept Biomed Sci & Human Oncol, Paediat Sect, Bari, Italy. [VanErpecum, Karel] Univ Med Ctr, Dept Gastroenterol & Hepatol, Utrecht, Netherlands. C3 Universita degli Studi di Bari Aldo Moro; Universita degli Studi di Bari Aldo Moro; Universita degli Studi di Bari Aldo Moro; Utrecht University; Utrecht University Medical Center RP Portincasa, P (通讯作者)，Univ Bari, Sch Med, Dept Biomed Sci & Human Oncol, Clin Med Augusto Murri, Piazza Giulio Cesare 11, I-70124 Bari, Italy. EM piero.portincasa@uniba.it RI Di Ciaula, Agostino/AAW-3499-2021; portincasa, piero/J-7245-2018; Faienza, Maria/K-6779-2016; Shanmugam, Harshitha/LCE-0958-2024 OI Di Ciaula, Agostino/0000-0002-5476-7376; portincasa, piero/0000-0001-5359-1471; Molina Molina, Emilio/0000-0003-4390-5275; Garruti, Gabriella/0000-0001-7875-7239; Shanmugam, Harshitha/0000-0002-3711-2175 FU European Union's Horizon 2020 Research and Innovation framework, under the Marie Sklodowska-Curie Grant [722619]; Foie Gras Early Research Training Grant FX The present work is written in the context of the project FOIE GRAS, which has received funding from the European Union's Horizon 2020 Research and Innovation framework, under the Marie Sklodowska-Curie Grant Agreement No. 722619. 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J. Clin. Invest. PD JUL PY 2021 VL 51 IS 7 AR e13597 DI 10.1111/eci.13597 EA MAY 2021 PG 15 WC Medicine, General & Internal; Medicine, Research & Experimental WE Science Citation Index Expanded (SCI-EXPANDED) SC General & Internal Medicine; Research & Experimental Medicine GA SV4EU UT WOS:000653700100001 PM 34032283 OA Green Submitted, Bronze DA 2026-02-02 ER PT J AU Alvarez-Amor, L Sierra, AL Cárdenas, A López-Bermudo, L López-Beas, J Andújar, E Pérez-Alegre, M Gallego-Durán, R Varela, LM Martin-Montalvo, A Berná, G Rojas, A Robles-Frías, MJ Hmadcha, A Romero-Gómez, M Kleemann, R Martín, F AF Alvarez-Amor, Leticia Luque Sierra, Amparo Cardenas, Antonio Lopez-Bermudo, Lucia Lopez-Beas, Javier Andujar, Eloisa Perez-Alegre, Monica Gallego-Duran, Rocio Varela, Lourdes M. Martin-Montalvo, Alejandro Berna, Genoveva Rojas, Anabel Jose Robles-Frias, Ma Hmadcha, Abdelkrim Romero-Gomez, Manuel Kleemann, Robert Martin, Franz TI Extra virgin olive oil improved body weight and insulin sensitivity in high fat diet-induced obese LDLr-/-.Leiden mice without attenuation of steatohepatitis SO SCIENTIFIC REPORTS LA English DT Article ID LIVER-DISEASE; HEPATIC STEATOSIS; RESISTANCE; GENE; INFLAMMATION; EXPRESSION; FIBROSIS; RECRUITMENT; SEVERITY; MARKERS AB Dietary fatty acids play a role in the pathogenesis of obesity-associated non-alcoholic fatty liver disease (NAFLD), which is associated with insulin resistance (IR). Fatty acid composition is critical for IR and subsequent NAFLD development. Extra-virgin olive oil (EVOO) is the main source of monounsaturated fatty acids (MUFA) in Mediterranean diets. This study examined whether EVOO-containing high fat diets may prevent diet-induced NAFLD using Ldlr-/-. Leiden mice. In female Ldlr-/-.Leiden mice, the effects of the following high fat diets (HFDs) were examined: a lard-based HFD (HFD-L); an EVOO-based HFD (HFD-EVOO); a phenolic compounds-rich EVOO HFD (HFD-OL). We studied changes in body weight (BW), lipid profile, transaminases, glucose homeostasis, liver pathology and transcriptome. Both EVOO diets reduced body weight (BW) and improved insulin sensitivity. The EVOOs did not improve transaminase values and increased LDL-cholesterol and liver collagen content. EVOOs and HFD-L groups had comparable liver steatosis. The profibrotic effects were substantiated by an up-regulation of gene transcripts related to glutathione metabolism, chemokine signaling and NF-kappa-B activation and down-regulation of genes relevant for fatty acid metabolism. Collectivelly, EVOO intake improved weight gain and insulin sensitivity but not liver inflammation and fibrosis, which was supported by changes in hepatic genes expression. C1 [Alvarez-Amor, Leticia; Luque Sierra, Amparo; Cardenas, Antonio; Lopez-Bermudo, Lucia; Lopez-Beas, Javier; Andujar, Eloisa; Perez-Alegre, Monica; Varela, Lourdes M.; Martin-Montalvo, Alejandro; Berna, Genoveva; Rojas, Anabel; Martin, Franz] Univ Pablo Olavide, Andalusian Ctr Mol Biol & Regenerat Med CABIMER, Univ Seville, CSIC, Seville, Spain. [Alvarez-Amor, Leticia; Cardenas, Antonio; Berna, Genoveva; Rojas, Anabel; Hmadcha, Abdelkrim; Martin, Franz] Inst Salud Carlos III, Biomed Res Network Diabet & Related Metab Dis CIB, Madrid, Spain. [Gallego-Duran, Rocio; Romero-Gomez, Manuel] Univ Seville, Hosp Univ Virgen del Rocio Sevilla, Inst Biomed Sevilla, Seville, Spain. [Gallego-Duran, Rocio; Romero-Gomez, Manuel] Inst Salud Carlos III, Biomed Res Network Hepat & Digest Dis CIBEREHD, Madrid, Spain. [Jose Robles-Frias, Ma] Hosp Univ Virgen del Rocio, Compared Pathol Unit, Intituto Biomed Sevilla Biobank Node, Andalucia Hlth Publ Syst Biobank, Seville, Spain. [Kleemann, Robert] Netherlands Org Appl Sci Res TNO, Dept Metab Hlth Res, NL-2333 CK Leiden, Netherlands. [Kleemann, Robert] Leiden Univ, Dept Vasc Surg, Med Ctr, NL-2333 ZA Leiden, Netherlands. C3 Consejo Superior de Investigaciones Cientificas (CSIC); Universidad Pablo de Olavide; University of Sevilla; CSIC - Centro Andaluz de Biologia Molecular y Medicina Regenerativa (CABIMER); Instituto de Salud Carlos III; Consejo Superior de Investigaciones Cientificas (CSIC); University of Sevilla; CSIC-JA-USE - Instituto de Biomedicina de Sevilla (IBIS); CIBER - Centro de Investigacion Biomedica en Red; CIBERDEM; Instituto de Salud Carlos III; CIBEREHD; Virgen del Rocio University Hospital; Netherlands Organization Applied Science Research; Leiden University; Leiden University Medical Center (LUMC); Leiden University - Excl LUMC RP Martín, F (通讯作者)，Univ Pablo Olavide, Andalusian Ctr Mol Biol & Regenerat Med CABIMER, Univ Seville, CSIC, Seville, Spain.; Martín, F (通讯作者)，Inst Salud Carlos III, Biomed Res Network Diabet & Related Metab Dis CIB, Madrid, Spain.; Kleemann, R (通讯作者)，Netherlands Org Appl Sci Res TNO, Dept Metab Hlth Res, NL-2333 CK Leiden, Netherlands.; Kleemann, R (通讯作者)，Leiden Univ, Dept Vasc Surg, Med Ctr, NL-2333 ZA Leiden, Netherlands. EM robert.kleemann@tno.nl; fmarber@upo.es RI Hmadcha, Abdelkrim/T-1173-2019; López-Beas, Javier/Q-3935-2018; Martin, Franz/K-4197-2014; VARELA PEREZ, LOURDES MARIA/M-4860-2015; Berna, Genoveva/AAG-7849-2020; Martin-Montalvo, Alejano/C-2031-2017; Luque Sierra, Amparo/J-9255-2017; Romero-Gómez, Manuel/L-8030-2014; López Bermudo, Lucía/AAR-3519-2021; Gallego-Durán, Rocío/AAB-1791-2020; Rojas, Anabel/E-8768-2014 OI Hmadcha, Abdelkrim/0000-0002-4105-3702; Martin, Franz/0000-0002-5745-8704; Pérez Alegre, Mónica/0000-0002-6060-6990; VARELA PEREZ, LOURDES MARIA/0000-0002-8875-6042; Berna, Genoveva/0000-0001-8185-8428; Martin-Montalvo, Alejano/0000-0002-3886-5355; Luque Sierra, Amparo/0000-0002-9090-3048; Romero-Gómez, Manuel/0000-0001-8494-8947; Andujar, Eloisa/0000-0002-8434-5078; Álvarez Amor, Leticia/0000-0003-4793-9130; López Bermudo, Lucía/0000-0002-1191-0275; FU Ministerio de Economia y Competitividad [AGL2014-54585-R, AGL-2017-86927-R, CP14/ 00105, PI18/01590, PAI-BIO311, CB07/08/0006]; Junta de Andalucia [PAI-BIO311]; Instituto de Salud Carlos III [CB07/08/0006]; TNO research programs [ERP 020, PMC13] FX We thank Dr. Elsbet Pieterman from the Netherlands Organisation for Applied Scientific Research (TNO) for kindly providing us with female Ldlr-/-.Leiden mice. This work was supported by the grants AGL2014-54585-R, AGL-2017-86927-R, CP14/ 00105, PI18/01590 (Ministerio de Economia y Competitividad), PAI-BIO311 (Junta de Andalucia), CB07/08/0006 (Instituto de Salud Carlos III) and by the TNO research programs "Body Brain Interactions ERP 020" and "Functional Biomarkers PMC13". 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Forsyth, Adrienne Itsiopoulos, Catherine Nicoll, Amanda J. Ryan, Marno Sood, Siddharth Roberts, Stuart K. Tierney, Audrey C. TI Practical Dietary Recommendations for the Prevention and Management of Nonalcoholic Fatty Liver Disease in Adults SO ADVANCES IN NUTRITION LA English DT Review DE nonalcoholic fatty liver disease; nonalcoholic steatohepatitis; diet; dietary recommendations; clinical guidelines ID CORONARY-HEART-DISEASE; MEDITERRANEAN DIET; METABOLIC SYNDROME; CARDIOVASCULAR-DISEASE; ALCOHOL-CONSUMPTION; OLIVE OIL; FRUCTOSE CONSUMPTION; INSULIN SENSITIVITY; COFFEE CONSUMPTION; DIABETES-MELLITUS AB Nonalcoholic fatty liver disease (NAFLD) is the most common liver diseaseworldwide. In the absence of effective pharmacotherapies, clinical guidelines focus primarily on weight loss to treat this condition. Established consensus, evidence-based, and clinical dietary recommendations for NAFLD are currently lacking. The aim of this paper is to provide evidence-based practical dietary recommendations for the prevention and management of NAFLD in adults. A literature review focusing on established principles for the development of clinical practice recommendations was employed using the following criteria: based on substantial evidence, ensures risk minimization, is flexible for an individual patient approach, and is open to further modification as evidence emerges. The Practice-based Evidence in Nutrition classification system was used to grade these principles. Five key dietary recommendations were developed: 1) follow traditional dietary patterns, such as the Mediterranean diet; 2) limit excess fructose consumption and avoid processed foods and beverages with added fructose; 3) PUFAs, especially long-chain omega-3 rich foods and MUFAs, should replace SFAs in the diet; 4) replace processed food, fast food, commercial bakery goods, and sweets with unprocessed foods high in fiber, including whole grains, vegetables, fruits, legumes, nuts, and seeds; and 5) avoid excess alcohol consumption. Improving diet quality may reduce the incidence and progression of NAFLD and associated risk factors. Many of the benefits are likely to result from the collective effect of dietary patterns. High-quality research-in particular, randomized clinical trials assessing dietary interventions that focus on liver-specific endpoints-are needed as a priority. C1 [George, Elena S.; Forsyth, Adrienne; Itsiopoulos, Catherine; Tierney, Audrey C.] La Trobe Univ, Dept Rehabil Nutr & Sport, Bundoora, Vic, Australia. [George, Elena S.; Tierney, Audrey C.] Alfred Hlth, Dept Nutr, Prahran, Vic, Australia. [Roberts, Stuart K.] Alfred Hlth, Dept Gastroenterol, Prahran, Vic, Australia. [Nicoll, Amanda J.] Eastern Hlth, Dept Gastroenterol, Box Hill, Vic, Australia. [Ryan, Marno] St Vincents Hosp, Dept Gastroenterol, Fitzroy, Vic, Australia. [Sood, Siddharth] Melbourne Hlth, Dept Gastroenterol, Parkville, Vic, Australia. C3 La Trobe University; Alfred Health; Alfred Health; Eastern Health; St Vincent's Health; St Vincent's Hospital Melbourne; NSW Health; St Vincents Hospital Sydney RP George, ES (通讯作者)，La Trobe Univ, Dept Rehabil Nutr & Sport, Bundoora, Vic, Australia.; George, ES (通讯作者)，Alfred Hlth, Dept Nutr, Prahran, Vic, Australia. EM e.george@latrobe.edu.au RI ; George, Elena/J-3357-2019; Forsyth, Aienne/ISB-2103-2023; Tierney, Auey/AAB-7068-2022 OI Sood, Siddharth/0000-0002-9341-4792; Roberts, Stuart/0000-0002-9015-7997; George, Elena/0000-0002-1385-2371; Forsyth, Aienne/0000-0002-1692-2638; Tierney, Auey/0000-0001-8562-2877; Nicoll, Amanda/0000-0002-1855-2757 FU Australian Government Research Training Program Scholarship FX ESG was supported by an Australian Government Research Training Program Scholarship. 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Nutr. PD JAN PY 2018 VL 9 IS 1 BP 30 EP 40 DI 10.1093/advances/nmx007 PG 11 WC Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Nutrition & Dietetics GA FV9AT UT WOS:000424879800004 PM 29438460 OA Green Submitted, Bronze DA 2026-02-02 ER PT J AU Armandi, A Schattenberg, JM AF Armandi, Angelo Schattenberg, Jorn M. TI Beyond the Paradigm of Weight Loss in Non-Alcoholic Fatty Liver Disease: From Pathophysiology to Novel Dietary Approaches SO NUTRIENTS LA English DT Review DE insulin; lifestyle; non-alcoholic; steatohepatitis; fibrosis; metabolic syndrome; weight loss; time-restricted feeding; intermittent fasting; low-carb diet; liver disease ID GLYCATION END-PRODUCTS; LIFE-STYLE MODIFICATION; MEDITERRANEAN DIET; INSULIN-RESISTANCE; HEPATIC STEATOSIS; METABOLIC SYNDROME; GLYCEMIC INDEX; CALORIC-INTAKE; CLINICAL CHARACTERISTICS; CONFERS SUSCEPTIBILITY AB Current treatment recommendations for non-alcoholic fatty liver disease (NAFLD) rely heavily on lifestyle interventions. The Mediterranean diet and physical activity, aiming at weight loss, have shown good results in achieving an improvement of this liver disease. However, concerns related to compliance and food accessibility limit the feasibility of this approach, and data on the long-term effects on liver-related outcomes are lacking. Insulin resistance is a central aspect in the pathophysiology of NAFLD; therefore, interventions aiming at the improvement of insulin sensitivity may be preferable. In this literature review, we provide a comprehensive summary of the available evidence on nutritional approaches in the management of NAFLD, involving low-calorie diets, isocaloric diets, and the novel schemes of intermittent fasting. In addition, we explore the harmful role of single nutrients on liver-specific key metabolic pathways, the role of gene susceptibility and microbiota, and behavioral aspects that may impact liver disease and are often underreported in clinical setting. At present, the high variability in terms of study populations and liver-specific outcomes within nutritional studies limits the generalizability of the results and highlights the urgent need of a tailored and standardized approach, as seen in regulatory trials in Non-Alcoholic Steatohepatitis (NASH). C1 [Armandi, Angelo] Univ Turin, Dept Med Sci, I-10126 Turin, Italy. [Armandi, Angelo; Schattenberg, Jorn M.] Johannes Gutenberg Univ Mainz, Univ Med Ctr, Dept Internal Med 1, D-55131 Mainz, Germany. [Schattenberg, Jorn M.] Johannes Gutenberg Univ Mainz, Univ Med Ctr, Dept Internal Med 1, Metab Liver Res Program, D-55131 Mainz, Germany. C3 University of Turin; Johannes Gutenberg University of Mainz; Johannes Gutenberg University of Mainz RP Schattenberg, JM (通讯作者)，Johannes Gutenberg Univ Mainz, Univ Med Ctr, Dept Internal Med 1, D-55131 Mainz, Germany.; Schattenberg, JM (通讯作者)，Johannes Gutenberg Univ Mainz, Univ Med Ctr, Dept Internal Med 1, Metab Liver Res Program, D-55131 Mainz, Germany. EM angelo.armandi@unito.it; joern.schattenberg@unimedizin-mainz.de RI Schattenberg, Jörn M/C-1301-2013; Armandi, Angelo/AAU-6395-2020 OI Schattenberg, Jörn M/0000-0002-4224-4703; Armandi, Angelo/0000-0002-7245-4445 FU European Union Innovative Medicines Initiative 2 (IMI2) Joint Undertaking [777377] FX This research received no external funding. J.M.S. is partly funded by the European Union Innovative Medicines Initiative 2 (IMI2) Joint Undertaking under grant agreement 777377: LITMUS (Liver Investigation: Testing Biomarker Utility in Steatohepatitis). 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Mayneris-Perxachs, Jordi Arola, Lluis Caimari, Antoni TI Mediterranean Diet and Multi-Ingredient-Based Interventions for the Management of Non-Alcoholic Fatty Liver Disease SO NUTRIENTS LA English DT Review DE non-alcoholic fatty liver disease; non-alcoholic steatohepatitis; hepatic steatosis; Mediterranean diet; multi-ingredient; polyunsaturated fatty acids; vitamins; synbiotics; silymarin; omics technologies ID RANDOMIZED CONTROLLED-TRIAL; VITAMIN-E; METABOLIC SYNDROME; HEPATIC STEATOSIS; LIFE-STYLE; SYNBIOTIC SUPPLEMENTATION; CARDIOVASCULAR-DISEASE; INSULIN SENSITIVITY; OXIDATIVE STRESS; ADIPOSE-TISSUE AB Non-alcoholic fatty liver disease (NAFLD) comprises a wide spectrum of hepatic disorders, from simple steatosis to hepatic necro-inflammation leading to non-alcoholic steatohepatitis (NASH). Although the prevalence of these multifactorial pathologies is continuously increasing in the population, there is still not an established methodology for their treatment other than weight loss and a change in lifestyle habits, such as a hypocaloric diet and physical exercise. In this framework, there is increasing evidence that several food bioactives and dietary patterns are effective for reversing and preventing the onset of these pathologies. Some studies have claimed that better responses are obtained when treatments are performed under a multifaceted approach, using different bioactive compounds that act against complementary targets. Thus, in this work, current strategies for treating NAFLD and NASH based on multi-ingredient-based supplements or the Mediterranean diet, a dietary pattern rich in bioactive compounds, are reviewed. Furthermore, the usefulness of omics techniques to design effective multi-ingredient nutritional interventions and to predict and monitor their response against these disorders is also discussed. C1 [Suarez, Manuel; Arola, Lluis] Univ Rovira & Virgili, Dept Biochem & Biotechnol, Nutrigen Res Grp, Campus Sescelades, E-43007 Tarragona, Spain. [Boque, Noemi; del Bas, Josep M.; Mayneris-Perxachs, Jordi; Arola, Lluis; Caimari, Antoni] EURECAT Technol Ctr Catalonia, Technol Unit Nutr & Hlth, Avinguda Univ 1, Reus 43204, Spain. C3 Universitat Rovira i Virgili RP Caimari, A (通讯作者)，EURECAT Technol Ctr Catalonia, Technol Unit Nutr & Hlth, Avinguda Univ 1, Reus 43204, Spain. EM manuel.suarez@urv.cat; noemi.boque@eurecat.org; josep.delbas@eurecat.org; jordi.mayneris@eurecat.org; lluis.arola@urv.cat; antoni.caimari@ctns.cat RI Suarez Recio, Manuel/F-5039-2016; del Bas, Josep Maria/K-9310-2019; MAYNERIS-PERXACHS, JORDI/AAG-7724-2020; Arola, Lluís/C-6074-2011 OI Suarez Recio, Manuel/0000-0003-0122-8253; Caimari, Antoni/0000-0001-6144-0294; del Bas, Josep Maria/0000-0002-0700-2004; Boqué, Noemi/0000-0001-7173-5512; MAYNERIS-PERXACHS, JORDI/0000-0003-3788-3815; Arola, Lluís/0000-0003-2767-1974 FU ACC1O [TECCT11-1-0012]; Spanish Ministerio de Economia y Competitividad [AGL2013-40707-R, AGL2013-49500-EXP] FX The work was supported by ACC1O (TECCT11-1-0012) and the Spanish Ministerio de Economia y Competitividad (grant numbers AGL2013-40707-R and AGL2013-49500-EXP). 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CH-4052 BASEL, SWITZERLAND EI 2072-6643 J9 NUTRIENTS JI Nutrients PD OCT PY 2017 VL 9 IS 10 AR 1052 DI 10.3390/nu9101052 PG 31 WC Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Nutrition & Dietetics GA FM0DM UT WOS:000414629900008 PM 28937599 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Chiurazzi, M Cacciapuoti, N Di Lauro, M Nasti, G Ceparano, M Salomone, E Guida, B Lonardo, MS AF Chiurazzi, Martina Cacciapuoti, Nunzia Di Lauro, Mariastella Nasti, Gilda Ceparano, Margherita Salomone, Elisabetta Guida, Bruna Lonardo, Maria Serena TI The Synergic Effect of a Nutraceutical Supplementation Associated to a Mediterranean Hypocaloric Diet in a Population of Overweight/Obese Adults with NAFLD SO NUTRIENTS LA English DT Article DE hepatic steatosis; nutraceutical supplementation; obesity ID FATTY LIVER-DISEASE; VITAMIN-E; OBESITY; INDEXES AB Overweight/obesity is often associated with a non-alcoholic fatty liver disease (NAFLD). The study aim was to investigate the effects of a nutraceutical supplementation associated to a Mediterranean-hypocaloric-diet (MHD) on ultrasound-liver-steatosis (ULS) grade improvement in overweight/obese patients with NAFLD. A total of 68 subjects (BMI >= 25 kg/m(2)) with NAFLD were recruited, randomized into 2 groups and treated for 3 months: the Nutraceutical group was treated with MHD plus nutraceutical supplementation (Vitamin E, L-glutathione, silymarin and hepato-active compounds); the Control-group only with a MHD. Anthropometric measurements, body composition, biochemical parameters and Hepatic steatosis index (HSI) were evaluated at baseline and after 3 months; patients with HSI >36 underwent a liver ultrasound to determine liver steatosis grade (3 severe, 2 moderate, 1 mild). In all patients, a significant improvement in nutritional and biochemical parameters was observed after treatment. After treatment, the nutraceutical group showed a significant improvement in hepatic steatosis, either according to ULS-grade (11.1% and 5.6% of patients with mild and moderate liver steatosis, respectively, showed a complete NAFLD regression; 33.3% and 22.2% of patients with moderate and severe liver steatosis, respectively showed a regression to mild liver steatosis), or according to HSI (49.3 +/- 10.1 vs. 43.3 +/- 9.0, p = 0.01), suggesting that a healthy diet is still the best choice, although the use of specific supplements can enhance the efficacy of dietary intervention in overweight/obese patients with NAFLD. C1 [Chiurazzi, Martina; Cacciapuoti, Nunzia; Di Lauro, Mariastella; Nasti, Gilda; Ceparano, Margherita; Salomone, Elisabetta; Guida, Bruna; Lonardo, Maria Serena] Federico II Univ Naples, Dept Clin Med & Surg, Physiol Nutr Unit, I-80131 Naples, Italy. C3 University of Naples Federico II RP Chiurazzi, M (通讯作者)，Federico II Univ Naples, Dept Clin Med & Surg, Physiol Nutr Unit, I-80131 Naples, Italy. EM martina.chiurazzi88@gmail.com RI ; Chiurazzi, Martina/IAR-0330-2023 OI Nasti, Gilda/0000-0001-6436-0281; Lonardo, Maria Serena/0000-0002-3768-4480; Salomone, Elisabetta/0000-0002-6506-2670; Chiurazzi, Martina/0000-0003-2406-890X; Cacciapuoti, Nunzia/0000-0002-3595-3245 CR Abd El-Kader SM, 2015, WORLD J HEPATOL, V7, P846, DOI 10.4254/wjh.v7.i6.846 Abdel-Maboud M, 2020, THER ADV GASTROENTER, V13, DOI 10.1177/1756284820974917 Abenavoli L, 2017, NUTRIENTS, V9, DOI 10.3390/nu9080870 Aller R, 2015, EUR REV MED PHARMACO, V19, P3118 Amanullah I, 2019, POSTGRAD MED J, V95, P601, DOI 10.1136/postgradmedj-2018-136364 Bashir A, 2022, LIVER RES-PRC, V6, P72, DOI 10.1016/j.livres.2022.05.002 Carneros D, 2020, NUTRIENTS, V12, DOI 10.3390/nu12113472 Castera L, 2020, LIVER INT, V40, P77, DOI 10.1111/liv.14347 Curcio A, 2020, MEDICINA-LITHUANIA, V56, DOI 10.3390/medicina56100544 D'Espessailles A, 2022, NUTRITION, V94, DOI 10.1016/j.nut.2021.111539 Del Ben M, 2017, BRIT J CLIN PHARMACO, V83, P88, DOI 10.1111/bcp.12899 Dietrich P, 2014, BEST PRACT RES CL GA, V28, P637, DOI 10.1016/j.bpg.2014.07.008 El Hadi H, 2018, ANTIOXIDANTS-BASEL, V7, DOI 10.3390/antiox7010012 Fabbrini E, 2010, HEPATOLOGY, V51, P679, DOI 10.1002/hep.23280 Fatma A.M., 2018, J CAIRO U, V86, P1055, DOI [10.21608/mjcu.2018.55784, DOI 10.21608/MJCU.2018.55784] Fernández T, 2022, PLOS ONE, V17, DOI 10.1371/journal.pone.0263931 Flisiak-Jackiewicz M, 2021, J CLIN MED, V10, DOI 10.3390/jcm10050924 Gerges SH, 2021, LIFE SCI, V271, DOI 10.1016/j.lfs.2021.119220 Gillessen A, 2020, ADV THER, V37, P1279, DOI 10.1007/s12325-020-01251-y Godoy-Matos AF, 2020, DIABETOL METAB SYNDR, V12, DOI 10.1186/s13098-020-00570-y Han AL, 2022, METABOLITES, V12, DOI 10.3390/metabo12070664 Honda Y, 2017, BMC GASTROENTEROL, V17, DOI 10.1186/s12876-017-0652-3 Irie Makoto, 2016, Euroasian J Hepatogastroenterol, V6, P13, DOI [10.5005/jp-journals-10018-1159, 10.5005/jp-journals-10018-1159] Kolota A, 2021, APPL SCI-BASEL, V11, DOI 10.3390/app11135836 Lee JH, 2010, DIGEST LIVER DIS, V42, P503, DOI 10.1016/j.dld.2009.08.002 Mahamid M, 2018, NUTRIENTS, V10, DOI 10.3390/nu10040440 Mardinoglu A, 2019, NUTRIENTS, V11, DOI 10.3390/nu11071578 Marin V, 2017, NUTRIENTS, V9, DOI 10.3390/nu9091006 Mengesha T, 2021, BMC COMPLEMENT MED, V21, DOI 10.1186/s12906-021-03275-5 Mosca A, 2021, DIGEST LIVER DIS, V53, P1154, DOI 10.1016/j.dld.2020.09.021 Mourad AM, 2010, CHOLESTEROL, DOI 10.1155/2010/824813 Mumtaz Shaham, 2019, Clin Liver Dis (Hoboken), V13, P111, DOI [10.1002/cld.750, 10.1002/cld.750] Nobili V, 2006, ALIMENT PHARM THER, V24, P1553, DOI 10.1111/j.1365-2036.2006.03161.x Nobili V, 2019, ANTIOXID REDOX SIGN, V31, P127, DOI 10.1089/ars.2018.7704 Oh RC, 2017, AM FAM PHYSICIAN, V96, P709 Pacana T, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0136822 Panera N, 2022, NUTRIENTS, V14, DOI 10.3390/nu14183791 Petroni ML, 2019, NUTRIENTS, V11, DOI 10.3390/nu11123048 Piccoli A, 2002, NUTRITION, V18, P520, DOI 10.1016/S0899-9007(02)00771-2 Rha CS, 2019, ANTIOXIDANTS-BASEL, V8, DOI 10.3390/antiox8080278 Sattar N, 2014, BMJ-BRIT MED J, V349, DOI 10.1136/bmj.g4596 Siervo M, 2012, OBES RES CLIN PRACT, V6, pE63, DOI 10.1016/j.orcp.2011.05.001 SINU LARN-Livelli di Assunzione di Riferimento di Nutrienti, 2014, EN POP IT 4 REV Sumida Y, 2018, J GASTROENTEROL, V53, P362, DOI 10.1007/s00535-017-1415-1 Takahashi Y, 2014, WORLD J GASTROENTERO, V20, P15539, DOI 10.3748/wjg.v20.i42.15539 Tosti V, 2018, J GERONTOL A-BIOL, V73, P318, DOI 10.1093/gerona/glx227 Usman M, 2020, CUREUS J MED SCIENCE, V12, DOI 10.7759/cureus.9018 Weschawalit S, 2017, CLIN COSMET INV DERM, V10, P147, DOI 10.2147/CCID.S128339 Wong RJ, 2014, WORLD J HEPATOL, V6, P263, DOI 10.4254/wjh.v6.i5.263 Yu JS, 2016, GASTROENT RES PRACT, V2016, DOI 10.1155/2016/2862173 NR 50 TC 14 Z9 14 U1 0 U2 3 PU MDPI PI BASEL PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND EI 2072-6643 J9 NUTRIENTS JI Nutrients PD NOV PY 2022 VL 14 IS 22 AR 4750 DI 10.3390/nu14224750 PG 12 WC Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Nutrition & Dietetics GA 6K8AC UT WOS:000887716700001 PM 36432436 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Sun, J Jin, XL Li, YL AF Sun, Jing Jin, Xiuli Li, Yiling TI Current strategies for nonalcoholic fatty liver disease treatment (Review) SO INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE LA English DT Review DE NAFLD; NASH; insulin resistance; oxidative stress; inflammation; lipid accumulation ID ENDOPLASMIC-RETICULUM STRESS; HEPATIC LIPID-ACCUMULATION; VITAMIN-D; METABOLIC SYNDROME; DOUBLE-BLIND; INSULIN-RESISTANCE; OXIDATIVE STRESS; GUT MICROBIOTA; UP-REGULATION; SYNBIOTIC SUPPLEMENTATION AB Nonalcoholic fatty liver disease (NAFLD), the most common chronic hepatic disease, has become a leading health problem worldwide. The present review summarized the methods and mechanisms to treat NAFLD, including the Mediterranean diet, physical activity and exercise, bariatric surgery and specific therapeutic agents, including statins, peroxisome proliferator-activated receptor agonists, cenicriviroc and farnesoid X receptor agonists. Biologically active substances, such as peptides, alkaloids, polyphenolic compounds, silymarin, antibiotics, fatty acids, vitamins, probiotics, synbiotics and lamiaceae have also demonstrated actions that combat NAFLD. Considering their different mechanisms of action, combining some of them may prove an efficacious treatment for NAFLD. In this light, the present review describes recent progress and future prospects in treating NAFLD. C1 [Sun, Jing; Jin, Xiuli; Li, Yiling] China Med Univ, Dept Gastroenterol, Hosp 1, 155 Nanjing North St, Shenyang 110002, Liaoning, Peoples R China. 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PD OCT PY 2024 VL 54 IS 4 AR 88 DI 10.3892/ijmm.2024.5412 PG 15 WC Medicine, Research & Experimental WE Science Citation Index Expanded (SCI-EXPANDED) SC Research & Experimental Medicine GA D3X1E UT WOS:001295538200001 PM 39129305 OA Green Submitted, hybrid DA 2026-02-02 ER PT J AU Ramírez-Vélez, R Izquierdo, M Correa-Bautista, JE Correa-Rodríguez, M Schmidt Rio-Valle, J González-Jiménez, E González-Jiménez, K AF Ramirez-Velez, Robinson Izquierdo, Mikel Enrique Correa-Bautista, Jorge Correa-Rodriguez, Maria Schmidt Rio-Valle, Jacqueline Gonzalez-Jimenez, Emilio Gonzalez-Jimenez, Katherine TI Liver Fat Content and Body Fat Distribution in Youths with Excess Adiposity SO JOURNAL OF CLINICAL MEDICINE LA English DT Article DE fatty liver; adiposity; youths; diet; cardiorespiratory fitness ID CONTROLLED ATTENUATION PARAMETER; CARDIORESPIRATORY FITNESS; TRANSIENT ELASTOGRAPHY; HEPATIC STEATOSIS; VISCERAL FAT; RISK-FACTOR; MASS INDEX; DISEASE; CAP; PREVALENCE AB This study had two main objectives: To examine the association between body fat distribution and non-alcoholic fatty liver disease (NAFLD) and liver fat content, and to determine whether the relationship between NAFLD and regional body fat distribution, with respect to liver fat content in youths with excess adiposity, is independent of cardiorespiratory fitness (CRF) and a healthy diet. Liver fat content (controlled attenuation parameter (CAP)), body fat distribution (body mass index (BMI) z-score, waist circumference, waist-to-height ratio, fat mass/height, body fat percentage, total fat mass, android-to-gynoid fat mass ratio, visceral adipose tissue (VAT), and lean mass index, determined by dual-energy X-ray absorptiometry (DXA)), CRF (20-m shuttle-run test), and healthy diet (adherence to the Mediterranean diet by KIDMED questionnaire) were measured in 126 adolescents (66% girls) aged between 11 and 17 years. Participants were assigned to two groups according to the presence or absence of hepatic steatosis (CAP values >225 dB/m or <225 dB/m of liver fat, respectively). Considering the similar total fat values for the two groups (>30% by DXA), youths with NAFLD had higher fat distribution parameters than those without NAFLD, regardless of sex, age, puberty stage, lean mass index, CRF, and healthy diet (p < 0.01). In the non-NAFLD group, the association between hepatic fat and fat distribution parameters presented a similar pattern, although the association was statistically insignificant after adjusting for a potential confounding variable (ps > 0.05), except for the case of VAT. Body fat distribution parameters were higher in youths with NAFLD compared to those without NAFLD. Additionally, body fat distribution showed a significant association with liver fat content as assessed by CAP in youths with NAFLD independent of CRF and adherence to the Mediterranean diet, supporting the notion that upper body fat distribution might play a pivotal role in the development of NAFLD in adolescents. These results may have implications for the clinical management of youths with excess adiposity given the high prevalence of NAFLD in children and young adults. C1 [Ramirez-Velez, Robinson; Enrique Correa-Bautista, Jorge; Gonzalez-Jimenez, Katherine] Univ Rosario, Ctr Estudios Med Act Fis CEMA, Escuela Med & Ciencias Salud, Bogota 111221, Colombia. [Izquierdo, Mikel] Univ Publ Navarra, Dept Hlth Sci, Navarrabiomed,IdiSNA, CIBER Fragilidad & Evejecimiento Saludable CB16 1, Tudela 31006, Navarre, Spain. [Correa-Rodriguez, Maria; Schmidt Rio-Valle, Jacqueline; Gonzalez-Jimenez, Emilio] Univ Granada, Dept Enfermeria, Fac Ciencias Salud, Avda Ilustrac 60, E-18071 Granada, Spain. [Gonzalez-Jimenez, Katherine] Univ Manuela Beltran, Fac Salud, Grp Ejercicio Fis & Deportes, Programa Fisioterapia, Bogota 110231, Colombia. C3 Universidad del Rosario; Universidad Publica de Navarra; Navarrabiomed; University of Granada; Universidad Manuela Beltran - UMB RP Ramírez-Vélez, R (通讯作者)，Univ Rosario, Ctr Estudios Med Act Fis CEMA, Escuela Med & Ciencias Salud, Bogota 111221, Colombia. EM robinson.ramirez@urosario.edu.co; mikel.izquierdo@gmail.com; jorge.correa@urosario.edu.co; macoro@ugr.es; jschmidt@ugr.es; emigoji@ugr.es; katherine.gonzalez@docentes.umb.edu.co RI Correa-Bautista, Jorge Enrique/JDD-3131-2023; González-Jiménez, Emilio/I-6039-2017; Correa-Rodríguez, María/G-1793-2018; Ramírez-Vélez, Robinson/D-5311-2016; Izquierdo, Mikel/A-4894-2010; Schmidt-Riovalle, Jacqueline/I-6333-2017 OI Correa-Bautista, Jorge Enrique/0000-0002-0646-2316; González-Jiménez, Emilio/0000-0001-5103-6028; Correa-Rodríguez, María/0000-0001-9165-4349; Ramírez-Vélez, Robinson/0000-0003-3075-6960; Lo, Hau Ying Chloe/0000-0001-8390-6489; Izquierdo, Mikel/0000-0002-1506-4272; Schmidt-Riovalle, Jacqueline/0000-0003-2775-0058 FU Instituto Colombiano para el Desarrollo de la Ciencia y la Tecnologia "Francisco Jose de Caldas" COLCIENCIAS [59700, 122277757900]; Universidad del Rosario, Colombia, Escuela de Medicina y Ciencias de la Salud; Convocatoria de Comite de Becas 2017, Universidad del Rosario, Colombia; Ministerio de Economia, Industria y Competitividad (ISCIII, FEDER) [PI17/01814] FX The HEPAFIT Study was carried out with the financial support of Instituto Colombiano para el Desarrollo de la Ciencia y la Tecnologia "Francisco Jose de Caldas" COLCIENCIAS (contract code 59700 and no. 122277757900). K.G.-R. received a scholarship from the Universidad del Rosario, Colombia, Escuela de Medicina y Ciencias de la Salud, to do a Doctorate. R.R.-V. received funding from Convocatoria de Comite de Becas 2017, Universidad del Rosario, Colombia. M.I. is granted in part by a research grant PI17/01814 of the Ministerio de Economia, Industria y Competitividad (ISCIII, FEDER). The content of this paper reflects the authors' views alone, and the Colombian Community and COLCIENCIAS are not liable for any use that may be made of the information contained herein. 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Schwab, Ursula TI Dietary Interventions in Patients With Non-alcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis SO FRONTIERS IN NUTRITION LA English DT Review DE non-alcoholic fatty liver disease; diet intervention; liver fat; liver transaminases; lipid metabolism; glucose metabolism; systematic review; meta-analysis ID LIFE-STYLE MODIFICATION; MEDITERRANEAN DIET; WEIGHT-LOSS; CARDIOVASCULAR-DISEASE; ALCOHOL-CONSUMPTION; HEPATIC STEATOSIS; FIBROSIS STAGE; INCREASED RISK; PLANT STEROLS; NAFLD AB Background: With no approved pharmacotherapy to date, the present therapeutic cornerstone for non-alcoholic fatty liver diseases (NAFLD) is a lifestyle intervention. Guidelines endorse weight loss through dietary modifications, physical exercise, or both. However, no consensus exists on the optimal dietary treatment. Objectives: The aim of our systematic review and meta-analysis was to summarize and assess the evidence for applied types of dietary interventions on the liver and metabolic outcomes in patients with NAFLD, aside from any effects of exercise intervention. Methods: This systematic review was conducted according to the Preferred Reporting Items of Systematic Reviews and Meta-analysis (PRISMA) statement guidelines. The search was conducted in PubMed, Scopus, and Cochrane databases in February 2020. Included were only dietary interventions without exercise. This study was registered at PROSPERO: CRD42020203573. Results: Eight randomized controlled trials, seven with endpoint reduction of hepatic steatosis, one with an assessment of endpoint fibrosis, were included in this systematic review, five of which were included in the meta-analysis. Mediterranean dietary interventions without energy restriction (n = 3) showed significant reduction of intrahepatic lipid content (IHL) (SDM: -0.57, 95% CI: -1.04, -0.10), but there was no significant change in alanine transaminase (ALT) (SDM: 0.59, 95% CI: -0.5, -1.68). Hypocaloric dietary interventions with foods high in unsaturated fatty acids (n = 2) led to a significant decrease in ALT (SDM: -1.09, 95% CI: -1.49, -0.69) and aspartate aminotransferase (AST) (SDM: -0.75, 95% CI: -1.27, 0.23); yet effects on steatosis could not be aggregated due to different assessment techniques. Mediterranean diet did not lead to significant changes in concentrations of gamma-glutamyl transpeptidase (gamma GT), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglyceride (TG), fasting glucose or insulin, or homeostatic assessment for insulin resistance. Conclusions: In patients with NAFLD, Mediterranean and hypocaloric dietary interventions favoring unsaturated fatty acids result in improvements in IHL and transaminases. Since many dietary intervention studies are combined with exercise interventions and there is a paucity of ample-sized studies examining dietary interventions on the more advanced and clinically relevant stages of NAFLD, that is active and fibrotic NASH, with multiparametric imaging and liver histology as outcome measures, the optimal dietary invention in NAFLD remains to be defined. C1 [Houttu, Veera; Nieuwdorp, Max; Holleboom, Adriaan G.] Univ Amsterdam, Locat Amsterdam Med Ctr, Dept Vasc Med, Amsterdam Univ Med Ctr, Amsterdam, Netherlands. [Houttu, Veera; Nieuwdorp, Max; Holleboom, Adriaan G.] Univ Amsterdam, Locat Amsterdam Med Ctr, Dept Expt Vasc Med, Amsterdam Univ Med Ctr, Amsterdam, Netherlands. [Csader, Susanne; Schwab, Ursula] Univ Eastern Finland, Sch Med, Inst Publ Hlth & Clin Nutr, Kuopio, Finland. [Schwab, Ursula] Kuopio Univ Hosp, Dept Med Endocrinol & Clin Nutr, Kuopio, Finland. C3 University of Amsterdam; University of Amsterdam; University of Eastern Finland; University of Eastern Finland; University of Eastern Finland Hospital; Kuopio University Hospital RP Schwab, U (通讯作者)，Univ Eastern Finland, Sch Med, Inst Publ Hlth & Clin Nutr, Kuopio, Finland.; Schwab, U (通讯作者)，Kuopio Univ Hosp, Dept Med Endocrinol & Clin Nutr, Kuopio, Finland. EM ursula.schwab@uef.fi OI Holleboom, AG/0000-0002-2911-2917; Houttu, Veera/0000-0002-6430-7007 FU European Union [813781]; Amsterdam UMC Fellowship grant; Health-Holland TKIPPP grants; Gilead; Novo Nordisk; ZONMW VICI grant [09150182010020]; Marie Curie Actions (MSCA) [813781] Funding Source: Marie Curie Actions (MSCA) FX This work has received funding from the European Union's Horizon 2020 research and innovation program under the Marie Sklodowska-Curie grant agreement No. 813781 ITN BestTreat (on which SC and VH are appointed). AH was supported by the Amsterdam UMC Fellowship grant, Health-Holland TKIPPP grants, and by the research grants from Gilead and Novo Nordisk. MN was supported by a personal ZONMW VICI grant 2020 [09150182010020]. 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Nutr. PD JUL 22 PY 2021 VL 8 AR 716783 DI 10.3389/fnut.2021.716783 PG 15 WC Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Nutrition & Dietetics GA UE6GZ UT WOS:000687985500001 PM 34368214 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Berná, G Romero-Gomez, M AF Berna, Genoveva Romero-Gomez, Manuel TI The role of nutrition in non-alcoholic fatty liver disease: Pathophysiology and management SO LIVER INTERNATIONAL LA English DT Review DE artificial intelligence; dietary guidelines; macronutrients; micronutrients; nutritional geometry; personalized nutrition ID PHYSICAL-ACTIVITY; DIET; SEVERITY; FRUCTOSE; INJURY; NAFLD; MUFA AB A healthy diet together with physical activity could induce weight loss and control the progression of non-alcoholic fatty liver disease (NAFLD). However, the composition of diet has not been clearly established. Macronutrients such as saturated fatty acids (SFA), trans-fats, simple sugars and animal proteins have a harmful effect on the liver. On the other hand, monounsaturated fats (MUFAs), polyunsaturated (PUFAs) omega-3-fats, plant-based proteins and dietary fibres are considered to be beneficial to the liver. The impact of specific micronutrients is less well-known. Nutrients are part of the food we eat. Food makes up our meals, which compose our dietary patterns. Non-alcoholic fatty liver disease patients usually follow Western diets which are rich in soda, frozen junk food, juice, red meat, lard, processed meats, whole fat dairy foods, fatty snack foods, take-away foods, cakes and biscuits and poor in cereals, whole grains, fruit, vegetables, extra virgin olive oil (EVOO) and fish. On the other hand, the Mediterranean diet (MD) is beneficial for NAFLD even when it is iso-caloric or there are no changes in body weight. A new approach, called 'nutritional geometry' considers the importance of integrating nutrition, animals and the environment. The goal of this approach is to combine nutrients and foods in a model to understand how food components interact to regulate the properties of diets affecting health and disease. The use of algorithms developed by artificial intelligence (AI) to create a personalized diet for patients can provide customized nutritional counselling to prevent and treat NAFLD. C1 [Berna, Genoveva] Univ Pablo Olavide, CABIMER, Seville, Spain. [Berna, Genoveva] Inst Salud Carlos III, CIBERDEM, Seville, Spain. [Romero-Gomez, Manuel] Univ Seville, Inst Biomed Seville IBiS, SeLiver Grp, Virgen Rocio CSIC US,UCM Digest Dis, Seville, Spain. [Romero-Gomez, Manuel] Univ Seville, Inst Biomed Seville IBiS, SeLiver Grp, Virgen Rocio CSIC US,CIBERehd, Seville, Spain. C3 Universidad Pablo de Olavide; CIBER - Centro de Investigacion Biomedica en Red; CIBERDEM; Instituto de Salud Carlos III; Consejo Superior de Investigaciones Cientificas (CSIC); University of Sevilla; CSIC-JA-USE - Instituto de Biomedicina de Sevilla (IBIS); Consejo Superior de Investigaciones Cientificas (CSIC); University of Sevilla; CSIC-JA-USE - Instituto de Biomedicina de Sevilla (IBIS); CIBER - Centro de Investigacion Biomedica en Red; CIBEREHD RP Romero-Gómez, M (通讯作者)，Hosp Univ Virgen Rocio, Digest Dis Unit, Av ManuelSiurot S-N, Seville 410013, Spain. EM mromerogomez@us.es RI Romero-Gómez, Manuel/L-8030-2014; Berna, Genoveva/AAG-7849-2020 OI Romero-Gómez, Manuel/0000-0001-8494-8947; Berna, Genoveva/0000-0001-8185-8428 FU Ministerio de Economia y Competitividad [AGL2017-86927-R]; Junta de Andalucia [PAI-BIO311] FX This work was partially supported by the Ministerio de Economia y Competitividad (grant number AGL2017-86927-R) and Junta de Andalucia (PAI-BIO311). 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PD FEB PY 2020 VL 40 SU 1 SI SI BP 102 EP 108 DI 10.1111/liv.14360 PG 7 WC Gastroenterology & Hepatology WE Science Citation Index Expanded (SCI-EXPANDED) SC Gastroenterology & Hepatology GA LJ1WS UT WOS:000529963000016 PM 32077594 OA Bronze DA 2026-02-02 ER PT J AU Zhang, Z Li, S Sun, JJ AF Zhang, Zhen Li, Shuai Sun, Jianjun TI Efficacy of different interventions for nonalcoholic fatty liver disease: A meta-analysis of lifestyle modifications, silymarin, and medications SO ASIA PACIFIC JOURNAL OF CLINICAL NUTRITION LA English DT Review DE lifestyle modification; silymarin; nonalcoholic fatty liver disease; meta-analysis; Mediterranean hypocaloric diet ID MEDITERRANEAN DIET; INSULIN-RESISTANCE; GLYCEMIC INDEXES; VITAMIN-E; STEATOHEPATITIS; STEATOSIS; ENZYMES; PNPLA3; TRIAL AB Background and Objectives: To compare the effectiveness of silymarin or its combination with lifestyle modifications, Mediterranean hypocaloric diets, and medications for improving nonalcoholic fatty liver disease (NAFLD). Methods and Study Design: PubMed, Embase, Cochrane Library, Web of Science, and Clinical-Trails.gov were used to identify relevant studies. The treatment arm was silymarin or its combination with Mediterranean hypocaloric diets, medications, or lifestyle modifications. The comparators were placebo, Mediterranean hypocaloric diets, medications, and lifestyle modifications. Results: This meta-analysis included 25 studies with 2283 patients. Total cholesterol levels were reduced by silymarin+Mediterranean hypocaloric diets (SMD:- 0.39 (-0.81, 0.03), p=0.072) or medications [SMD:-1.12 (-1.67,-0.58), p<0.001]. Triglyceride levels were decreased by silymarin combined with the medication [SMD:-0.92 (-1.98, 0.14), p=0.080]. Low-density lipoprotein cholesterol levels were reduced by silymarin alone [SMD:-0.25 (-0.48,-0.03), p=0.027]. The combination of silymarin with Mediterranean hypocaloric diets [SMD:-0.47 (-0.90,-0.04), p=0.031] or lifestyle modifications [SMD:-0.88 (-1.09,-0.66), p<0.0001] decreased alanine aminotransferase levels. Aspartate aminotransferase levels were reduced by a combination of silymarin and lifestyle modifications [SMD:-0.72 (-1.49, 0.05), p=0.061] or medications [SMD:-1.41 (-2.24,-0.59), p=0.005]. Silymarin (2.5 times) or silymarin plus lifestyle modifications (39%) reduced the hepatic steatosis rate in patients with NAFLD. The silymarin use increased the rate of patients with adverse effects [RR:1.98 (1.11, 3.54)]; gastrointestinal problems were the most common adverse effects. Conclusions: Despite the overall advantages of therapies, different interventions showed different effects on markers in patients with NAFLD. These results highlight the need for more research to fully comprehend the features of the intervention. C1 [Zhang, Zhen; Li, Shuai; Sun, Jianjun] Philippine Womens Univ, Sch Nursing, Manila, Philippines. C3 Philippine Women's University RP Zhang, Z (通讯作者)，Philippine Womens Univ, 1743 Taft Ave, Manila 1004, Philippines. 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TI Aerobic Physical Activity and a Low Glycemic Diet Reduce the AA/EPA Ratio in Red Blood Cell Membranes of Patients with NAFLD SO NUTRIENTS LA English DT Article DE physical activity; polyunsaturated fatty acids; erythrocyte membrane; non-alcoholic fatty liver disease ID FATTY LIVER-DISEASE; CARDIOVASCULAR-DISEASE; EICOSAPENTAENOIC ACID; ULTRASOUND; CANCER; INDEX AB Omega-6 Polyunsaturated Fatty Acids (PUFAs), through the eicosanoids derived from arachidonic acid (AA), are able to modulate the inflammatory processes, whereas omega-3 PUFAs, such as eicosapentaenoic acid (EPA), exert anti-oxidant and anti-inflammatory effects. An unbalanced AA/EPA ratio in favor of AA leads to the development of different metabolic disorders, including non-alcoholic fatty liver disease (NAFLD). The aim of the present study was to evaluate the effects of different diets, alone and in combination with two physical activity programs, on the AA/EPA ratio value in erythrocyte membranes of patients with NAFLD. One hundred forty-two subjects with NAFLD were enrolled in the study and randomized into six treatment groups. AA/EPA ratio was significantly reduced after 90 days of treatment with only a program of aerobic activity. However, it appears that the combination of physical activity and a Low Glycemic Index Mediterranean Diet (LGIMD) was more efficacious in reducing AA/EPA levels, at 45 days of treatment, even if this effect was not maintained over time. The combined effect of diet and physical activity reduced the AA/EPA ratio value improving the score of steatosis. Dietary intake of omega-3 PUFAs, in association with a healthy lifestyle, may be used in the prevention protocols for many chronic diseases, including NAFLD. C1 [Tutino, Valeria; De Nunzio, Valentina; Notarnicola, Maria] Natl Inst Gastroenterol S de Bellis Res Hosp, Lab Nutr Biochem, I-70013 Castellana Grotte, Ba, Italy. [Caruso, Maria Gabriella; De Leonardis, Giampiero] Natl Inst Gastroenterol S de Bellis Res Hosp, Ambulatory Clin Nutr, I-70013 Castellana Grotte, Ba, Italy. [Bonfiglio, Caterina; Franco, Isabella; Mirizzi, Antonella; Osella, Alberto R.] Natl Inst Gastroenterol S de Bellis Res Hosp, Lab Epidemiol & Biostat, I-70013 Castellana Grotte, Ba, Italy. [Cozzolongo, Raffaele; Giannuzzi, Vito] Natl Inst Gastroenterol S de Bellis Res Hosp, Dept Gastroenterol 1, I-70013 Castellana Grotte, Ba, Italy. [Giannelli, Gianluigi] Natl Inst Gastroenterol S de Bellis Res Hosp, Sci Direct, I-70013 Castellana Grotte, Ba, Italy. RP Notarnicola, M (通讯作者)，Natl Inst Gastroenterol S de Bellis Res Hosp, Lab Nutr Biochem, I-70013 Castellana Grotte, Ba, Italy. EM valeria.tutino@irccsdebellis.it; valentinadx@hotmail.it; gabriella.caruso@irccsdebellis.it; catia.bonfiglio@irccsdebellis.it; isabella.franco@irccsdebellis.it; antonella.mirizzi@irccsdebellis.it; giampierodl@gmail.com; raffaelecln1@alice.it; v55567@alice.it; gianluigi.giannelli@irccsdebellis.it; maria.notarnicola@irccsdebellis.it; arosella@irccsdebellis.it RI Osella, Alberto/M-6888-2014; cozzolongo, raffaele/ABH-5696-2020; giannelli, gianluigi/A-8169-2012 OI Osella, Alberto/0000-0003-4232-8760; cozzolongo, raffaele/0000-0002-8343-5864; FU Italian Ministry of Health [RC 2012-2014, Linea 4, C. 32 (D.D.G. n. 110/2014)] Funding Source: Medline CR Alberti-Fidanza A, 2004, PUBLIC HEALTH NUTR, V7, P937, DOI 10.1079/PHN2004557 [Anonymous], LINEE GUIDA SANA ALI Berzigotti A, 2014, REV RECENT CLIN TRIA, V9, P170, DOI 10.2174/1574887109666141216101630 Berzigotti A, 2014, J HEPATOL, V60, P910, DOI 10.1016/j.jhep.2014.01.017 Chiloiro M, 2013, METAB SYNDR RELAT D, V11, P349, DOI 10.1089/met.2012.0169 Coviello G, 2014, ANTICANCER RES, V34, P4775 Craig CL, 2003, MED SCI SPORT EXER, V35, P1381, DOI 10.1249/01.MSS.0000078924.61453.FB FOLCH J, 1957, J BIOL CHEM, V226, P497 Han Xuesheng, 2018, Journal of Dietary Supplements, V15, P153, DOI [10.1080/19390211.2017.1331943, 10.1080/19390211.2017.1331943] Innes JK, 2018, PROSTAG LEUKOTR ESS, V132, P41, DOI 10.1016/j.plefa.2018.03.004 Juárez-Hernández E, 2016, NUTR J, V15, DOI 10.1186/s12937-016-0191-8 Kyle UG, 2004, CLIN NUTR, V23, P1430, DOI 10.1016/j.clnu.2004.09.012 Mansara PP, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0136542 Misciagna G, 2017, J NUTR HEALTH AGING, V21, P404, DOI 10.1007/s12603-016-0809-8 MOILANEN T, 1981, CLIN CHIM ACTA, V114, P111, DOI 10.1016/0009-8981(81)90235-7 Monteiro J, 2014, FOOD FUNCT, V5, P426, DOI 10.1039/c3fo60551e Notarnicola M, 2017, LIPIDS HEALTH DIS, V16, DOI 10.1186/s12944-017-0552-0 Osotchuk S S, 2014, Klin Lab Diagn, P17 Pahlavani M, 2017, J NUTR BIOCHEM, V39, P101, DOI 10.1016/j.jnutbio.2016.08.012 Puri P, 2007, HEPATOLOGY, V46, P1081, DOI 10.1002/hep.21763 Riboli E, 2002, PUBLIC HEALTH NUTR, V5, P1113, DOI 10.1079/PHN2002394 Rizzo AM, 2010, LIPIDS HEALTH DIS, V9, DOI 10.1186/1476-511X-9-7 Rizzo AM, 2012, NUTR J, V11, DOI 10.1186/1475-2891-11-82 Saini RK, 2018, LIFE SCI, V203, P255, DOI 10.1016/j.lfs.2018.04.049 Simopoulos AP, 2006, BIOMED PHARMACOTHER, V60, P502, DOI 10.1016/j.biopha.2006.07.080 Simopoulos AP, 2002, J AM COLL NUTR, V21, P495, DOI 10.1080/07315724.2002.10719248 Simopoulos AP, 2008, EXP BIOL MED, V233, P674, DOI 10.3181/0711-MR-311 Simopoulos AP, 2016, NUTRIENTS, V8, DOI 10.3390/nu8030128 Simopoulos AP, 2016, OPEN HEART, V3, DOI 10.1136/openhrt-2015-000385 SKINNER HA, 1982, J STUD ALCOHOL, V43, P1157, DOI 10.15288/jsa.1982.43.1157 Street SJ, 2015, AGING MENT HEALTH, V19, P885, DOI 10.1080/13607863.2014.971705 Thompson W., 2009, ACSMS GUIDELINES EXE Welk GJ., 2002, PHYS ACTIVITY ASSESS NR 33 TC 32 Z9 34 U1 0 U2 7 PU MDPI PI BASEL PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND EI 2072-6643 J9 NUTRIENTS JI Nutrients PD SEP PY 2018 VL 10 IS 9 AR 1299 DI 10.3390/nu10091299 PG 16 WC Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Nutrition & Dietetics GA GY5YI UT WOS:000448659900172 PM 30217048 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Ballestri, S Tana, C Di Girolamo, M Fontana, MC Capitelli, M Lonardo, A Cioni, G AF Ballestri, Stefano Tana, Claudio Di Girolamo, Maria Fontana, Maria Cristina Capitelli, Mariano Lonardo, Amedeo Cioni, Giorgio TI Semi-Quantitative Ultrasonographic Evaluation of NAFLD SO CURRENT PHARMACEUTICAL DESIGN LA English DT Review DE Atherosclerosis; cardiometabolic risk; conventional ultrasound; hepatic fibrosis; hepatic steatosis; liver biopsy; metabolic derangements ID NONALCOHOLIC FATTY LIVER; CONTROLLED ATTENUATION PARAMETER; CORONARY-ARTERY CALCIFICATION; HEPATIC STEATOSIS INDEX; MEDITERRANEAN DIET; CARDIOVASCULAR-DISEASE; NONINVASIVE EVALUATION; NONDIABETIC PATIENTS; PORTAL-HYPERTENSION; METABOLIC SYNDROME AB Nonalcoholic fatty liver disease (NAFLD) embraces histopathological entities ranging from the relatively benign simple steatosis to the progressive form nonalcoholic steatohepatitis (NASH), which is associated with fibrosis and an increased risk of progression to cirrhosis and hepatocellular carcinoma. NAFLD is the most common liver disease and is associated with extrahepatic comorbidities including a major cardiovascular disease burden. The non-invasive diagnosis of NAFLD and the identification of subjects at risk of progressive liver disease and cardio-metabolic complications are key in implementing personalized treatment schedules and follow-up strategies. In this review, we highlight the potential role of ultrasound semiquantitative scores for detecting and assessing steatosis severity, progression of NAFLD, and cardio-metabolic risk. Ultrasonographic scores of fatty liver severity act as sensors of cardio-metabolic health and may assist in selecting patients to submit to second-line non-invasive imaging techniques and/or liver biopsy. C1 [Ballestri, Stefano; Tana, Claudio; Di Girolamo, Maria; Fontana, Maria Cristina; Capitelli, Mariano; Lonardo, Amedeo; Cioni, Giorgio] Azienda USL, Pavullo Hosp, Internal Med Unit, Modena, Italy. 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Pharm. Design PY 2020 VL 26 IS 32 BP 3915 EP 3927 DI 10.2174/1381612826666200417142444 PG 13 WC Pharmacology & Pharmacy WE Science Citation Index Expanded (SCI-EXPANDED) SC Pharmacology & Pharmacy GA NV9RQ UT WOS:000574649400004 PM 32303161 DA 2026-02-02 ER PT J AU Notarnicola, M Osella, AR Caruso, MG Pesole, PL Lippolis, A Tutino, V Bonfiglio, C De Nunzio, V Scavo, MP Mirizzi, A Franco, I Lippolis, T D'Alessandro, R Refolo, MG Messa, C AF Notarnicola, Maria Osella, Alberto Ruben Caruso, Maria Gabriella Pesole, Pasqua Letizia Lippolis, Antonio Tutino, Valeria Bonfiglio, Caterina De Nunzio, Valentina Scavo, Maria Principia Mirizzi, Antonella Franco, Isabella Lippolis, Tamara D'Alessandro, Rosalba Refolo, Maria Grazia Messa, Caterina TI Nonalcoholic Fatty Liver Disease: Focus on New Biomarkers and Lifestyle Interventions SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES LA English DT Review DE NAFLD; fatty acids; exosomes; cytokeratins; lipid metabolism; Mediterranean diet; physical activity ID INDUCED OXIDATIVE STRESS; HEPATIC STELLATE CELLS; ACID LIPASE ACTIVITY; EXTRACELLULAR VESICLES; PHYSICAL-ACTIVITY; GUT MICROBIOTA; CONFERS SUSCEPTIBILITY; CARDIOVASCULAR-DISEASE; INSULIN-RESISTANCE; LIPID-ACCUMULATION AB Nonalcoholic fatty liver disease (NAFLD) is considered a hepatic manifestation of metabolic syndrome, characterized from pathological changes in lipid and carbohydrate metabolism. Its main characteristics are excessive lipid accumulation and oxidative stress, which create a lipotoxic environment in hepatocytes leading to liver injury. Recently, many studies have focused on the identification of the genetic and epigenetic modifications that also contribute to NAFLD pathogenesis and their prognostic implications. The present review is aimed to discuss on cellular and metabolic alterations associated with NAFLD, which can be helpful to identify new noninvasive biomarkers. The identification of accumulated lipids in the cell membranes, as well as circulating cytokeratins and exosomes, provides new insights in understanding of NAFLD. This review also suggests that lifestyle modifications remain the main prevention and/or treatment for NAFLD. C1 [Notarnicola, Maria; Tutino, Valeria; De Nunzio, Valentina; Lippolis, Tamara] S de Bellis Res Hosp, Natl Inst Gastroenterol, Lab Nutr Biochem, I-70013 Castellana Grotte, BA, Italy. [Osella, Alberto Ruben; Bonfiglio, Caterina; Mirizzi, Antonella; Franco, Isabella] S de Bellis Res Hosp, Natl Inst Gastroenterol, Lab Epidemiol & Biostat, I-70013 Castellana Grotte, BA, Italy. [Caruso, Maria Gabriella] S de Bellis Res Hosp, Natl Inst Gastroenterol, Ambulatory Clin Nutr, I-70013 Castellana Grotte, BA, Italy. [Pesole, Pasqua Letizia; Lippolis, Antonio] S de Bellis Res Hosp, Natl Inst Gastroenterol, Clin Pathol Lab, I-70013 Castellana Grotte, BA, Italy. [Scavo, Maria Principia] S de Bellis Res Hosp, Natl Inst Gastroenterol, Lab Personalized Med, I-70013 Castellana Grotte, BA, Italy. [D'Alessandro, Rosalba; Refolo, Maria Grazia; Messa, Caterina] S de Bellis Res Hosp, Natl Inst Gastroenterol, Lab Cellular & Mol Biol, I-70013 Castellana Grotte, BA, Italy. RP Notarnicola, M (通讯作者)，S de Bellis Res Hosp, Natl Inst Gastroenterol, Lab Nutr Biochem, I-70013 Castellana Grotte, BA, Italy. EM maria.notarnicola@irccsdebellis.it; ar.osella@irccsdebellis.it; gabriella.caruso@irccsdebellis.it; pesoleletizia@gmail.com; antonio.lippolis@irccsdebellis.it; valeria.tutino@irccsdebellis.it; catia.bonfiglio@irccsdebellis.it; valentinadx@hotmail.it; maria.scavo@irccsdebellis.it; antonella.mirizzi@irccsdebellis.it; isabella.franco@irccsdebellis.it; lippolis.tamara@gmail.com; rosalba.dalessandro@irccsdebellis.it; maria.refolo@irccsdebellis.it; caterina.messa@irccsdebellis.it RI Scavo, Maria/AAR-6713-2020; D'Alessano, Rosalba/J-2351-2018 OI pesole, pasqua letizia/0000-0003-4675-2075; Bonfiglio, Caterina/0000-0002-8650-348X; Caruso, Maria Gabriella/0000-0003-4518-6307; Lippolis, Tamara/0000-0001-8983-0331; D'Alessano, Rosalba/0000-0001-9604-366X FU [700/2020]; [15] FX This work was supported by RC2020-2021, Prog. Nffi 15 (DDG. n. 700/2020). 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J. Mol. Sci. PD APR PY 2021 VL 22 IS 8 AR 3899 DI 10.3390/ijms22083899 PG 17 WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary WE Science Citation Index Expanded (SCI-EXPANDED) SC Biochemistry & Molecular Biology; Chemistry GA RT3CR UT WOS:000644340800001 PM 33918878 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Cakir, M Akbulut, UE Okten, A AF Cakir, Murat Akbulut, Ulas Emre Okten, Aysenur TI Association between Adherence to the Mediterranean Diet and Presence of Nonalcoholic Fatty Liver Disease in Children SO CHILDHOOD OBESITY LA English DT Article ID INSULIN-RESISTANCE; ADOLESCENTS; OBESITY; HEALTH; CONSUMPTION; STEATOSIS; DIAGNOSIS; NUT AB Objective: The study's objective was to analyze the association between the adherence to the Mediterranean diet (MD) and the presence of nonalcoholic fatty liver disease (NAFLD) in children. Methods: The study consisted of three groups of children. Group 1 included obese/overweight children with recent diagnosis of NAFLD (n=106, 12.42.6 years). Group 2 included obese children without NAFLD (n=21, 11.32.6 years). Group 3 included the healthy children (without known chronic disease) with normal BMI (n=54, 11.82.9 years). Compliance to the MD was assessed by the KIDMED index score. Results: KIDMED index score in obese children with NAFLD, without NAFLD, and healthy children were 2.6 +/- 2.4, 4.6 +/- 1.2, and 6.2 +/- 1.9, respectively (p<0.05 for group 1 versus 2, 1 versus 3, and 2 versus 3). Diet compliance was good in only 4.7% of the patients with NAFLD, whereas it was 31.5% in healthy children. KIDMED index score was negatively correlated with BMI (p<0.05, r=-0.53), but no correlation was found with other parameters. The area under the receiver operation curve (AUROC) for predicting fatty liver disease in obese children (n=127) with BMI and KIDMED index score was 0.78 (p<0.05) and 0.24 (p<0.05), respectively. BMI >26 has a sensitivity of 79.2% and specificity of 52.4%, and KIDMED index score 3 has a sensitivity of 66.9% and specificity of 76.1%. Conclusions: MD is an inexpensive and nontoxic dietary regimen and may be used as a therapeutic option in obese children with NAFLD. C1 [Cakir, Murat; Akbulut, Ulas Emre] Karadeniz Tech Univ, Fac Med, Dept Pediat Gastroenterol Hepatol & Nutr, Trabzon, Turkey. [Okten, Aysenur] Karadeniz Tech Univ, Fac Med, Dept Pediat Endocrinol, Trabzon, Turkey. C3 Karadeniz Technical University; Karadeniz Technical University RP Cakir, M (通讯作者)，Karadeniz Tech Univ, Fac Med, Dept Pediat Gastroenterol Hepatol & Nutr, Trabzon, Turkey. 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PD AUG PY 2016 VL 12 IS 4 BP 279 EP 285 DI 10.1089/chi.2015.0197 PG 7 WC Pediatrics WE Science Citation Index Expanded (SCI-EXPANDED) SC Pediatrics GA DT3YJ UT WOS:000381416800006 PM 26871614 DA 2026-02-02 ER PT J AU Baratta, F Pastori, D Polimeni, L Bucci, T Ceci, F Calabrese, C Ernesti, I Pannitteri, G Violi, F Angelico, F Del Ben, M AF Baratta, Francesco Pastori, Daniele Polimeni, Licia Bucci, Tommaso Ceci, Fabrizio Calabrese, Cinzia Ernesti, Ilaria Pannitteri, Gaetano Violi, Francesco Angelico, Francesco Del Ben, Maria TI Adherence to Mediterranean Diet and Non-Alcoholic Fatty Liver Disease: Effect on Insulin Resistance SO AMERICAN JOURNAL OF GASTROENTEROLOGY LA English DT Article ID METABOLIC SYNDROME; OXIDATIVE STRESS; POPULATION; PREVALENCE; RISK; QUESTIONNAIRE; INFLAMMATION; ASSOCIATION; GUIDELINES; MANAGEMENT AB OBJECTIVES: The prevalence of cardiometabolic disorders, including non-alcoholic fatty liver disease (NAFLD), is increasing in western countries, because of changes in lifestyle and dietary habits. Mediterranean Diet (Med-Diet) is effective for cardiovascular prevention, but its relationship with NAFLD has been scarcely investigated. METHODS: We included 584 consecutive outpatients presenting with one or more cardiovascular risk factor such as type 2 diabetes mellitus (T2DM), arterial hypertension, overweight/obesity, and dyslipidemia. Liver steatosis was assessed using ultrasonography. Med-Diet adherence was investigated by a validated semiquantitative nine-item dietary questionnaire; patients were divided into low, intermediate, and high adherence. Insulin resistance was defined by the 75th percentile of homeostasis model of insulin resistance (HOMA-IR; >= 3.8). RESULTS: The mean age was 56.2 +/- 12.4 years and 38.2% were women. Liver steatosis was present in 82.7%, and its prevalence decreased from low to high adherence group (96.5% vs. 71.4%, P<0.001). In a multiple logistic regression analysis, hypertriglyceridemia (odds ratio (OR): 2.913; P=0.002), log (ALT) (OR: 6.186; P<0.001), Med-Diet adherence (intermediate vs. low OR: 0.115; P=0.041, high vs. low OR: 0.093; P=0.030), T2DM (OR: 3.940; P=0.003), and high waist circumference (OR: 3.012; P<0.001) were associated with NAFLD. Among single foods, low meat intake (OR: 0.178; P<0.001) was inversely significantly associated with NAFLD. In 334 non-diabetic NAFLD patients, age (OR: 1.035, P=0.025), high waist circumference (OR: 7.855, P<0.001), hypertriglyceridemia (OR: 2.152, P=0.011), and Log (ALT) (OR: 2.549, P=0.002) were directly associated with HOMA-IR, whereas Med-Diet score was inversely associated (OR: 0.801, P=0.018). CONCLUSIONS: We found an inverse relationship between Med-Diet and NAFLD prevalence. Among NAFLD patients, good adherence to Med-Diet was associated with lower insulin resistance. Our findings suggest that Med-Diet may be a beneficial nutritional approach in NAFLD patients. C1 [Baratta, Francesco; Pastori, Daniele; Polimeni, Licia; Violi, Francesco] Sapienza Univ Rome, Dept Internal Med & Med Specialties, Clin Med 1, Viale Policlin 155, I-00161 Rome, Italy. [Baratta, Francesco; Pastori, Daniele] Sapienza Univ Rome, Dept Anat Histol Forens Med & Orthoped Sci, Rome, Italy. [Bucci, Tommaso] Salerno Univ Med, Dept Med Specialties, Salerno, Italy. [Ceci, Fabrizio] Univ Roma La Sapienza, Dept Cellular Biotechnol & Hematol, Policlin Umberto Hosp 1, Rome, Italy. [Ernesti, Ilaria] Sapienza Univ, Sect Med Pathophysiol Endocrinol & Nutr, Dept Expt Med, Rome, Italy. [Pannitteri, Gaetano] Sapienza Univ Rome, Dept Cardiovasc Resp Nephrol Anaesthesiol & Geria, Rome, Italy. [Angelico, Francesco] Sapienza Univ Rome, Dept Publ Hlth & Infect Dis, Rome, Italy. C3 Sapienza University Rome; Sapienza University Rome; Sapienza University Rome; University Hospital Sapienza Rome; Sapienza University Rome; Sapienza University Rome; Sapienza University Rome RP Pastori, D (通讯作者)，Sapienza Univ Rome, Dept Internal Med & Med Specialties, Clin Med 1, Viale Policlin 155, I-00161 Rome, Italy. EM daniele.pastori@uniroma1.it RI pastori, daniele/J-7087-2016; Bucci, Tommaso/ABA-4162-2021; Violi, Francesco/K-1509-2016; Del Ben, Maria/AAE-7603-2020; Angelico, Francesco/AAB-6585-2020 OI pastori, daniele/0000-0001-6357-5213; Bucci, Tommaso/0000-0003-2895-6234; Calabrese, Cinzia Myriam/0000-0001-5376-0298; Baratta, Francesco/0000-0003-1708-272X; CR Abenavoli L, 2014, WORLD J GASTROENTERO, V20, P16831, DOI 10.3748/wjg.v20.i45.16831 Allman-Farinelli M, 2016, CURR OBES REP, V5, P23, DOI 10.1007/s13679-016-0189-8 [Anonymous], document submitted to UNESCO to inscribe then on the Representative List of the Intangible Cultural Heritage of Humanity, Form ICH-02 Argo CK, 2009, CLIN LIVER DIS, V13, P511, DOI 10.1016/j.cld.2009.07.005 Babio N, 2009, NUTR METAB CARDIOVAS, V19, P563, DOI 10.1016/j.numecd.2008.10.007 Chen JH, 2016, NUTRIENTS, V8, DOI 10.3390/nu8100643 Davis C, 2015, NUTRIENTS, V7, P9139, DOI 10.3390/nu7115459 Del Ben M, 2014, BMC GASTROENTEROL, V14, DOI 10.1186/1471-230X-14-81 Della Corte C, 2017, NUTRITION, V39-40, P8, DOI 10.1016/j.nut.2017.02.008 Donini LM, 2015, BRIT J NUTR, V113, pS1, DOI 10.1017/S0007114515001087 Dunn W, 2008, HEPATOLOGY, V47, P1947, DOI 10.1002/hep.22292 Eckel RH, 2014, CIRCULATION, V129, pS76, DOI 10.1161/01.cir.0000437740.48606.d1 Esposito K, 2004, JAMA-J AM MED ASSOC, V292, P1440, DOI 10.1001/jama.292.12.1440 Evans JL, 2003, DIABETES, V52, P1, DOI 10.2337/diabetes.52.1.1 FerroLuzzi A, 1995, WHO TECH REP SER, V854, P1 Fraser A, 2008, DIABETOLOGIA, V51, P1616, DOI 10.1007/s00125-008-1049-1 Cabrera SG, 2015, NUTR HOSP, V32, P2390, DOI 10.3305/nh.2015.32.6.9828 Garcia M, 2016, NUTRIENTS, V8, DOI 10.3390/nu8030168 Gayoso-Diz P, 2013, BMC ENDOCR DISORD, V13, DOI 10.1186/1472-6823-13-47 Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404 Hamaguchi M, 2007, AM J GASTROENTEROL, V102, P2708, DOI 10.1111/j.1572-0241.2007.01526.x Kani AH, 2014, NUTRITION, V30, P814, DOI 10.1016/j.nut.2013.11.008 Karamanos B, 2002, EUR J CLIN NUTR, V56, P983, DOI 10.1038/sj.ejcn.1601413 Keita H, 2013, DIABETOL METAB SYNDR, V5, DOI 10.1186/1758-5996-5-53 Keys A, 1966, Acta Med Scand Suppl, V460, P1 Mancia G, 2013, J HYPERTENS, V31, P1925, DOI 10.1097/HJH.0b013e328364ca4c Marchesini G, 2016, J HEPATOL, V64, P1388, DOI 10.1016/j.jhep.2015.11.004 Marchesini G, 2016, HEPATOLOGY, V63, P2032, DOI 10.1002/hep.28392 Marques-Vidal P, 2002, DIABETES CARE, V25, P1371, DOI 10.2337/diacare.25.8.1371 Martínez-González MA, 2004, EUR J CLIN NUTR, V58, P1550, DOI 10.1038/sj.ejcn.1602004 Martínez-González MA, 2002, EUR J NUTR, V41, P153, DOI 10.1007/s00394-002-0370-6 MARTINMORENO JM, 1993, INT J EPIDEMIOL, V22, P512, DOI 10.1093/ije/22.3.512 Pais R, 2016, J HEPATOL, V65, P1245, DOI 10.1016/j.jhep.2016.07.033 Papamiltiadous ES, 2016, BMC GASTROENTEROL, V16, DOI 10.1186/s12876-016-0426-3 Park YM, 2017, J NUTR, V147, P563, DOI 10.3945/jn.116.243543 Pastori D, 2015, ANTIOXID REDOX SIGN, V23, P682, DOI 10.1089/ars.2015.6326 Pelucchi C, 2010, EUR J CLIN NUTR, V64, P1052, DOI 10.1038/ejcn.2010.158 Polimeni L, 2015, WORLD J HEPATOL, V7, P1325, DOI 10.4254/wjh.v7.i10.1325 Ratziu V, 2010, J HEPATOL, V53, P372, DOI 10.1016/j.jhep.2010.04.008 Reiner Z, 2011, EUR HEART J, V32, P1769, DOI [10.1093/eurheartj/ehr158, 10.1016/j.atherosclerosis.2011.06.012] Ryan MC, 2013, J HEPATOL, V59, P138, DOI 10.1016/j.jhep.2013.02.012 Rydén L, 2013, EUR HEART J, V34, P3035, DOI 10.1093/eurheartj/eht108 Salas-Salvadó J, 2016, J NUTR, V146, p920S, DOI 10.3945/jn.115.218487 Sofi F, 2008, BMJ-BRIT MED J, V337, DOI 10.1136/bmj.a1344 Spahis S, 2017, ANTIOXID REDOX SIGN, V26, P519, DOI 10.1089/ars.2016.6776 Thoma C, 2012, J HEPATOL, V56, P255, DOI 10.1016/j.jhep.2011.06.010 Trichopoulou A, 2003, NEW ENGL J MED, V348, P2599, DOI 10.1056/NEJMoa025039 Trovato FM, 2015, CLIN NUTR, V34, P86, DOI 10.1016/j.clnu.2014.01.018 VERSCHUREN WMM, 1995, JAMA-J AM MED ASSOC, V274, P131, DOI 10.1001/jama.274.2.131 Zamora-Ros R, 2013, NUTR METAB CARDIOVAS, V23, P1167, DOI 10.1016/j.numecd.2012.12.008 Zelber-Sagil S, 2007, J HEPATOL, V47, P711, DOI 10.1016/j.jhep.2007.06.020 NR 51 TC 127 Z9 138 U1 0 U2 23 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0002-9270 EI 1572-0241 J9 AM J GASTROENTEROL JI Am. J. Gastroenterol. PD DEC PY 2017 VL 112 IS 12 BP 1832 EP 1839 DI 10.1038/ajg.2017.371 PG 8 WC Gastroenterology & Hepatology WE Science Citation Index Expanded (SCI-EXPANDED) SC Gastroenterology & Hepatology GA FP3HR UT WOS:000417509800016 PM 29063908 DA 2026-02-02 ER PT J AU Trovato, FM Castrogiovanni, P Szychlinska, MA Purrello, F Musumeci, G AF Trovato, Francesca Maria Castrogiovanni, Paola Szychlinska, Marta Anna Purrello, Francesco Musumeci, Giuseppe TI Early effects of high-fat diet, extra-virgin olive oil and vitamin D in a sedentary rat model of non-alcoholic fatty liver disease SO HISTOLOGY AND HISTOPATHOLOGY LA English DT Article DE Non-Alcoholic Fatty Liver Disease; Western Diet; Mediterranean Diet; Histology; Immunohistochemistry ID CARTILAGE DEGENERATION; MEDITERRANEAN DIET; IN-VIVO; WNT; ADHERENCE; FIBROSIS; EXERCISE; SYSTEM AB Background and Aim. Western high-fat diet is related to metabolic syndrome and non-alcoholic fatty liver disease (NAFLD). Decreased levels of Vitamin D (VitD) and IGF-1 and their mutual relationship were also reported. We aimed to evaluate whether different dietary profiles, containing or not VitD, may exert different effects on liver tissue. Methods. Twenty-eight male rats were fed for 10 weeks by different dietary regimens: R, regular diet; R-DS and R-DR, regular diet with respectively VitD supplementation (DS) and restriction (DR); HFB-DS and HFB-DR (41% energy from fat), high fat (butter) diet; HFEVO-DS and HFEVO-DR (41% energy from fat), high fat (Extra-virgin olive oil-EVO) diet. Severity of NAFLD was assessed by NAFLD Activity Score. Collagen type I, IL-1beta, VitD-receptor, DKK-1 and IGF1 expressions were evaluated by immunohistochemistry. Results. All samples showed a NAS between 0 and 2 considered not diagnostic of steatohepatitis. Collagen I, although weakly expressed, was statistically greater in HFB-DS and HFB-DR groups. IL-1 was mostly expressed in rats fed with HFBs and HFEVOs and R-DR, and almost absent in R and R-DS diets. IGF-1 and DKK-1 were reduced in HFBs and HFEVOs diets and in particular in DR groups. Conclusions. A short-term high-fat diet could damage liver tissue in terms of inflammation and collagen I deposition, setting the basis for the subsequent steatohepatitis, still not identifiable anatomopathologically. Vitamin D restriction increases inflammation and reduces the expression of IGF-1 in the liver, worsening the fat-induced changing. EVOO seems be protective against the collagen I production. C1 [Trovato, Francesca Maria; Purrello, Francesco] Univ Catania, Internal Med Unit, Dept Clin & Expt Med, Catania, Italy. [Castrogiovanni, Paola; Szychlinska, Marta Anna; Musumeci, Giuseppe] Univ Catania, Dept Biomed & Biotechnol Sci, Human Anat & Histol Sect, Catania, Italy. C3 University of Catania; University of Catania RP Musumeci, G (通讯作者)，Univ Catania, Dept Biomed & Biotechnol Sci, Human Anat & Histol Sect, Catania, Italy. EM g.musumeci@unict.it RI Castrogiovanni, Paola/E-3152-2013; Musumeci, Giuseppe/K-9955-2016; PURRELLO, Francesco Salvatore/K-9721-2016; SZYCHLINSKA, Marta Anna/AAA-5720-2021 OI Musumeci, Giuseppe/0000-0002-8260-8890; PURRELLO, Francesco Salvatore/0000-0003-3313-8543; SZYCHLINSKA, Marta Anna/0000-0001-5281-1516 FU University Research Project Grant (Triennial Research Plan), Department of Biomedical and Biotechnological Sciences (BIOMETEC), University of Catania, Italy FX This study was supported by the University Research Project Grant (Triennial Research Plan 2016-2018), Department of Biomedical and Biotechnological Sciences (BIOMETEC), University of Catania, Italy. The authors would like to thank "Oleificio Guccione di Divita Vito e G. SAS" to provide us the extra virgin Sicilian olive oil and Prof. Iain Halliday for commenting and making corrections to the paper. 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Histopath. PD NOV PY 2018 VL 33 IS 11 BP 1201 EP 1213 DI 10.14670/HH-18-008 PG 13 WC Cell Biology; Pathology WE Science Citation Index Expanded (SCI-EXPANDED) SC Cell Biology; Pathology GA GV5UQ UT WOS:000446170100007 PM 29855033 DA 2026-02-02 ER PT J AU Yurtdas, G Akbulut, G Baran, M Yilmaz, C AF Yurtdas, Gamze Akbulut, Gamze Baran, Masallah Yilmaz, Canan TI The effects of Mediterranean diet on hepatic steatosis, oxidative stress, and inflammation in adolescents with non-alcoholic fatty liver disease: A randomized controlled trial SO PEDIATRIC OBESITY LA English DT Article DE adolescent; inflammation; insulin resistance; Mediterranean diet; non-alcoholic fatty liver disease; oxidative stress ID WEIGHT-LOSS; METABOLIC SYNDROME; EXPERT COMMITTEE; DIAGNOSIS; CHILDREN; SUPPLEMENTATION; RECOMMENDATIONS; SEVERITY; PATTERN; OBESITY AB Background Non-alcoholic fatty liver disease (NAFLD) has become the most common liver disease in children and adolescents. The optimal dietary strategy to improve hepatic stetatosis and reduce oxidative stress and inflammation in adolescents is unknown. Objective This study was conducted to evaluate the effect of Mediterranean diet (MD) versus low-fat diet (LFD) on hepatic steatosis, inflammation, and oxidative stress in adolescents with obesity and NAFLD. Methods Adolescents diagnosed with NAFLD between the ages of 11-18 years were randomized to either a MD or conventional LFD (control diet) for 12 weeks. Dietary status, anthropometry, body composition, and biochemical parameters were evaluated. Hepatic steatosis was determined by ultrasonography. Results A total of 44 participants completed the study. At the end of the study, severity of hepatic steatosis, serum transaminase levels, and insulin resistance decreased significantly in both groups with no significant differences between groups except for aspartate aminotransferase (AST). The amount of decrease in AST levels in the MD group was greater than the LFD group (p < 0.05). In the MD group, serum total antioxidant capacity, paraoxanase-1, and glutathione peroxidase levels increased (p < 0.05); it did not change in the LFD group compared to baseline (p > 0.05). C-Reactive Protein (CRP) levels decreased only in the MD group (p = 0.008), interleukine-6 decreased only in the LFD group (p = 0.031). Conclusion Consumption of MD and LFD for 12 weeks in adolescents with obesity and NAFLD reduced BMI, fat mass, hepatic steatosis, and insulin resistance, improved high transaminase levels, and had positive effects on inflammation and oxidative stress. Registered under Identifier no. NCT04845373. C1 [Yurtdas, Gamze] Izmir Katip Celebi Univ, Fac Hlth Sci, Dept Nutr & Dietet, Izmir, Turkey. [Akbulut, Gamze] Gazi Univ, Fac Hlth Sci, Dept Nutr & Dietet, Ankara, Turkey. [Baran, Masallah] Izmir Katip Celebi Univ, Fac Med, Dept Pediat Gastroenterol Hepatol & Nutr, Izmir, Turkey. [Yilmaz, Canan] Gazi Univ, Fac Med, Dept Biochem, Ankara, Turkey. C3 Izmir Katip Celebi University; Gazi University; Izmir Katip Celebi University; Gazi University RP Yurtdas, G (通讯作者)，Izmir Katip Celebi Univ, Fac Hlth Sci, Dept Nutr & Dietet, Cigli Ana Yerleskesi Merkezi Ofisler, TR-35620 Cigli Izmir, Turkey. EM gmzyurtdas@hotmail.com RI YILMAZ, CANAN/AAT-7788-2020; Yurtdaş Depboylu, Gamze/ACA-1910-2022; Baran, Masallah/ACJ-1208-2022 OI YILMAZ, CANAN/0000-0002-6799-6522; Yurtdaş Depboylu, Gamze/0000-0001-5410-7231; Baran, Masallah/0000-0003-3827-2039 FU Gazi University Scientific Research Projects (BAP) unit [47/2020-05] FX This study was supported by Gazi University Scientific Research Projects (BAP) unit (project code: 47/2020-05). 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Obes. PD APR PY 2022 VL 17 IS 4 AR e12872 DI 10.1111/ijpo.12872 EA DEC 2021 PG 12 WC Pediatrics WE Science Citation Index Expanded (SCI-EXPANDED) SC Pediatrics GA ZS1CG UT WOS:000728740900001 PM 34881510 DA 2026-02-02 ER PT J AU Xiong, YL Shi, XY Xiong, XY Li, SY Zhao, HH Song, HL Wang, JY Zhang, L You, SF Ji, G Liu, BC Wu, N AF Xiong, Yalan Shi, Xinyu Xiong, Xinying Li, Shenyu Zhao, Hanhua Song, Hualing Wang, Jianying Zhang, Lei You, Shengfu Ji, Guang Liu, Baocheng Wu, Na TI A systematic review and meta-analysis of randomized controlled trials: effects of mediterranean diet and low-fat diet on liver enzymes and liver fat content of NAFLD SO FOOD & FUNCTION LA English DT Review ID WEIGHT-LOSS; CARDIOVASCULAR-DISEASE; HEPATIC STEATOSIS; LOW-CARBOHYDRATE; BREAST-CANCER; RISK; ADIPONECTIN; EXPRESSION AB Background: Non-alcoholic fatty liver disease (NAFLD) has emerged as a leading cause of several chronic diseases, imposing a significant global economic burden. The Mediterranean diet (MD) and low-fat diet (LFD) are the two primary recommended dietary patterns that exhibit distinct positive effects on treating NAFLD. Objective: To investigate which of the two diets, MD and LFD, is more effective in the treatment of NAFLD. Methods: Randomized controlled trials (RCTs) up to April 2024 were searched for in PubMed, Web of Science, Medline, Scopus and Embase. Interventions included MD or LFD, with primary outcome measures being intrahepatic lipid, liver stiffness, triglycerides, total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, alanine aminotransferase, gamma-glutamyl transferase, and homeostasis model assessment of insulin resistance. Secondary outcomes included weight, waist circumference, and body mass index. Use of random effects meta-analysis to assess outcomes of interest. Results: meta-analysis revealed no significant differences between MD and LFD in improving liver enzymes, liver fat, and related indices in NAFLD patients. Our findings provide compelling evidence for patients and healthcare professionals, allowing patients to choose a dietary pattern that aligns with their preferences and disease conditions. In summary, both MD and LFD can equivalently ameliorate NAFLD in the short term. Conclusions: Our results show that MD and LFD have similar therapeutic effects on liver enzymes and liver fat content in patients with NAFLD in the short term. Furthermore, our meta-analysis results have also opened up a new avenue of thought as to whether similar effects are achieved by alternating MD and LFD on alternate days. From the RCTs, the MD and LFD have similar effects on improving liver enzymes and liver fat content in NAFLD for the short term. C1 [Xiong, Yalan; Shi, Xinyu; Xiong, Xinying; Li, Shenyu; Song, Hualing; Wang, Jianying; Zhang, Lei; Ji, Guang; Liu, Baocheng; Wu, Na] Shanghai Univ Tradit Chinese Med, Shanghai Innovat Ctr Tradit Chinese Med Hlth Serv, Sch Publ Hlth, Shanghai 201203, Peoples R China. [Ji, Guang; Liu, Baocheng; Wu, Na] Shanghai Univ Tradit Chinese Med, State Key Lab Integrat & Innovat Class Formula & M, Shanghai 201203, Peoples R China. [You, Shengfu; Ji, Guang] Shanghai Univ Tradit Chinese Med, Longhua Hosp, Inst Digest Dis, Shanghai 200032, Peoples R China. [Zhao, Hanhua] Zhejiang Univ, Coll Educ, Dept Sport Sci, Hangzhou, Peoples R China. C3 Shanghai University of Traditional Chinese Medicine; Shanghai University of Traditional Chinese Medicine; Shanghai University of Traditional Chinese Medicine; Zhejiang University RP Liu, BC; Wu, N (通讯作者)，Shanghai Univ Tradit Chinese Med, Shanghai Innovat Ctr Tradit Chinese Med Hlth Serv, Sch Publ Hlth, Shanghai 201203, Peoples R China.; Liu, BC; Wu, N (通讯作者)，Shanghai Univ Tradit Chinese Med, State Key Lab Integrat & Innovat Class Formula & M, Shanghai 201203, Peoples R China. EM baochliu_lab@163.com; wuna0308@163.com RI xiong, xinying/MCK-2607-2025 OI xiong, yalan/0009-0007-7780-3986 FU National Natural Science Foundation of China [(2021-2023)-0211]; Three-year action plan for Shanghai [81973730]; National Natural Science Foundation of China [2022 (22010504300)]; Local Colleges Faculty Constitution of Shanghai MSTC [02-37]; Shanghai Collaborative Innovation Center for Chronic Disease Prevention and Health Services (2021 Science and Technology) [2022QN014]; Shanghai Health Commission for Traditional Chinese Medicine Research [2022 (2022M722164)]; China Postdoctoral Science Foundation [23YF1447700, 2023 (GJ202303)]; Shanghai 2023 "Science and Technology Innovation Action Plan" Qi Ming Xing Cultivation [2021LK008]; Shanghai University of Traditional Chinese Medicine FX We would like to thank the participants and investigators of all included trials for their contributions. All authors have reviewed and consented to the finalized version of the manuscript. We would also like to thank the teachers and students of the Collaborative Innovation Centre for TCM Health Services at the Shanghai University of Traditional Chinese Medicine for their help. This work was supported by Three-year action plan for Shanghai (project number: ZY (2021-2023)-0211); National Natural Science Foundation of China (81973730); Local Colleges Faculty Constitution of Shanghai MSTC 2022 (22010504300); Shanghai Collaborative Innovation Center for Chronic Disease Prevention and Health Services (2021 Science and Technology 02-37); Shanghai Health Commission for Traditional Chinese Medicine Research (2022QN014); China Postdoctoral Science Foundation, No. 72 General Fund, 2022 (2022M722164); Shanghai 2023 "Science and Technology Innovation Action Plan" Qi Ming Xing Cultivation (Yang Fan Project, 23YF1447700); Subject Connotation Construction Project in School of Public Health, Shanghai University of Traditional Chinese Medicine, 2023 (GJ202303); Shanghai University of Traditional Chinese Medicine, 2021 budgeted project (2021LK008). 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PD AUG 12 PY 2024 VL 15 IS 16 BP 8248 EP 8257 DI 10.1039/d4fo01461h EA JUL 2024 PG 10 WC Biochemistry & Molecular Biology; Food Science & Technology WE Science Citation Index Expanded (SCI-EXPANDED) SC Biochemistry & Molecular Biology; Food Science & Technology GA C4A3D UT WOS:001279284600001 PM 39076035 DA 2026-02-02 ER PT J AU Arrese, M Barrera, F Triantafilo, N Arab, JP AF Arrese, Marco Barrera, Francisco Triantafilo, Nicolas Pablo Arab, Juan TI Concurrent nonalcoholic fatty liver disease and type 2 diabetes: diagnostic and therapeutic considerations SO EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY LA English DT Review DE Nonalcoholic fatty liver disease; fatty liver disease; hepatology; diabetes; insulin resistance ID VITAMIN-E SUPPLEMENTATION; CARDIOVASCULAR-DISEASE; HEPATIC STEATOSIS; BARIATRIC SURGERY; NATURAL-HISTORY; TRANSIENT ELASTOGRAPHY; MEDITERRANEAN DIET; ADVANCED FIBROSIS; PRIMARY-CARE; ALCOHOLIC STEATOHEPATITIS AB Introduction: The relationship between nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM) is complex and bidirectional. NAFLD increases the risk of incident diabetes and is very prevalent in T2DM patients and T2DM is an aggravating factor for NAFLD. Timely T2DM diagnosis and treatment in subjects with NAFLD and diagnosis, staging and treatment of NAFLD in those with T2DM are critical issues. Areas covered: PubMed/MEDLINE was searched for articles related to concomitant occurrence of NAFLD and T2DM between January 2013 and May 2019. Areas covered included epidemiological, diagnostic and therapeutic aspects. Expert opinion: there is a need for increased awareness on NAFLD adding liver disease as an end-organ complication of T2DM. Emphasis on use of simple non-invasive tools to triage patients with potentially severe liver disease should be made. Management of patients with NAFLD and T2DM relies on lifestyle optimization to achieve significant weight loss. Currently, there is no drug approved for treatment of NAFLD in patients with T2DM although Vitamin E and pioglitazone might be used in selected patients. Approved diabetic medications hold promise for NAFLD treatment and several liver-specific drugs are in evaluation clinical trials. A combination approach will likely represent the future of NAFLD therapeutics. C1 [Arrese, Marco; Barrera, Francisco; Pablo Arab, Juan] Pontificia Univ Catolica Chile, Escuela Med, Dept Gastroenterol, Santiago, Chile. [Arrese, Marco] Pontificia Univ Catolica Chile, Fac Ciencias Biol, Ctr Envejecimiento & Regenerac CARE, Dept Biol Celular & Mol, Santiago, Chile. [Triantafilo, Nicolas] Pontificia Univ Catolica Chile, Escuela Med, Dept Hematol & Oncol, Santiago, Chile. C3 Pontificia Universidad Catolica de Chile; Pontificia Universidad Catolica de Chile; Pontificia Universidad Catolica de Chile RP Arrese, M (通讯作者)，Pontificia Univ Catolica Chile, Fac Med, Dept Gastroenterol, Marcoleta 367, Santiago 8330024, Chile. EM marco.arrese@gmail.com RI ; Arrese, Marco/ABB-9061-2021; Arab, Juan Pablo/J-5674-2019 OI Barrera, Francisco/0000-0001-5334-1528; Arrese, Marco/0000-0002-0499-4191; Arab, Juan Pablo/0000-0002-8561-396X FU Fondo Nacional de Desarrollo Cientifico y Tecnologico (FONDECYT) [1119145, 1191183]; Comision Nacional de Investigacion Cientifica y Tecnologica, grant CONICYT PIA/Basal, Basal Centre for Excellence in Science and Technology [PFB12] FX This article was partially supported by grants from the Fondo Nacional de Desarrollo Cientifico y Tecnologico (FONDECYT), grants 1119145 (to M. Arrese) and 1191183 (to F. Barrera) and from the Comision Nacional de Investigacion Cientifica y Tecnologica, grant CONICYT PIA/Basal PFB12, Basal Centre for Excellence in Science and Technology to M. Arrese. 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Gastroenterol. Hepatol. PD SEP 2 PY 2019 VL 13 IS 9 BP 849 EP 866 DI 10.1080/17474124.2019.1649981 EA AUG 2019 PG 18 WC Gastroenterology & Hepatology WE Science Citation Index Expanded (SCI-EXPANDED) SC Gastroenterology & Hepatology GA IS5TS UT WOS:000480998000001 PM 31353974 DA 2026-02-02 ER PT J AU Morales-Romero, J León, MCO Hernández-Gutierrez, H Bahena-Cerón, RA Miranda-Reza, A Marin-Carmona, JA Rodríguez-Romero, E Mora-Herrera, SI Garcia-Roman, J Peréz-Carreón, JI Rivadeneyra-Domínguez, E Riande-Juárez, G Garcia-Roman, R AF Morales-Romero, Jaime Leon, Maria Cristina Ortiz Hernandez-Gutierrez, Hector Bahena-Ceron, Roberto A. Miranda-Reza, Aide Marin-Carmona, Jose A. Rodriguez-Romero, Edit Mora-Herrera, Silvia I. Garcia-Roman, Jonathan Perez-Carreon, Julio I. Rivadeneyra-Dominguez, Eduardo Riande-Juarez, Gabriel Garcia-Roman, Rebeca TI Efficacy of nutrition therapy with food rich in methionine for treating nonalcoholic fatty liver SO ARCHIVOS LATINOAMERICANOS DE NUTRICION LA English DT Article DE methionine; NAFLD reversal; and nutrition therapy ID ADENOSYL-L-METHIONINE; VITAMIN-E; MEDITERRANEAN DIET; HEPATIC STEATOSIS; OXIDATIVE STRESS; SUPPLEMENTATION; DISEASE; STEATOHEPATITIS; PLACEBO; BETAINE AB Introduction. Non-Alcoholic Fatty Liver disease (NAFLD) can lead to Non Alcoholicsteatohepatitis (NASH), cirrhosis, and liver cancer. The treatment for NAFLD involvesmodification of caloric intake and physical activity. NAFLD has a pro-oxidant nature; therefore,it is logical to suppose that the antioxidant methionine can be used as a treatment for this disease. Aim. This study aimed to evaluate the effect of high-methionine dietary therapy on patients with NAFLD.Materials and methods. A randomized clinical study was conducted overthree months. In this study, 121 NAFLD patients participated, and the age of the participantswas & GE; 20 years (experimental group included 56 and control group 65), all of whom wererandomized and matched by sex, recluted from the ISSSTE hospital in Xalapa, Mexico. The patients were instructed to consume food to cover the recommended methionine daily doses and the daily amount consumed was calculated. Methionine effect was measured as NAFLDregression and quality of life improvement.Results. Nutritional therapy induced NAFLDregression and diminished central fat accumulation, blood pressure, and the fatty liver index. Some parameters, such as liver enzymes, did not changed. The quality of life of patientsimproved after treatment.Conclusions. In this study, we show a hepatoprotective effectinduced only in three months of chances in the diet, thus, a longer diet may generate more relevant benefits in the resistant parameters of our study C1 [Morales-Romero, Jaime; Leon, Maria Cristina Ortiz; Rodriguez-Romero, Edit; Riande-Juarez, Gabriel; Garcia-Roman, Rebeca] Univ Veracruzana, Inst Publ Hlth, Xalapa, Veracruz, Mexico. [Hernandez-Gutierrez, Hector] ISSSTE Hosp Clin, Xalapa, Veracruz, Mexico. [Bahena-Ceron, Roberto A.; Rivadeneyra-Dominguez, Eduardo] Univ Veracruzana, Fac Biol & Pharmaceut Chem, Xalapa, Veracruz, Mexico. [Miranda-Reza, Aide] Univ Veracruzana, Fac Stat & Informat, Xalapa, Veracruz, Mexico. [Marin-Carmona, Jose A.] Univ Veracruzana, Fac Biol, Xalapa, Veracruz, Mexico. [Mora-Herrera, Silvia I.] Univ Nacl Autonoma Mexico, Metabol & Prote Unit, Inst Biomed Res, Mexico City, Mexico. [Garcia-Roman, Jonathan] Univ Veracruzana, Fac Med Poza Rica Tuxpan Reg, Poza Rica, Veracruz, Mexico. [Perez-Carreon, Julio I.] Natl Inst Genom Med INMEGEN, Lab Hepat Dis, Mexico City, Mexico. C3 Universidad Veracruzana; Universidad Veracruzana; Universidad Veracruzana; Universidad Veracruzana; Universidad Nacional Autonoma de Mexico; Universidad Veracruzana; Instituto Nacional de Medicina Genomica RP Garcia-Roman, R (通讯作者)，Univ Veracruzana, Inst Publ Hlth, Xalapa, Veracruz, Mexico. EM rebgarcia@uv.mx RI Morales-Romero, Jaime/A-1442-2012; Mora-Herrera, Silvia/ISB-2730-2023; Garcia-Roman, Rebeca/LHA-1477-2024; rivadeneyra dominguez, eduardo/ABB-8363-2020; Ortiz-León, María Cristina/G-9569-2019 OI ROIGUEZ ROMERO, EDIT/0000-0003-1653-4835; rivadeneyra dominguez, eduardo/0000-0001-5662-2202; Pérez-Carreón, Julio Isael/0000-0001-9284-7775; Marín Carmona, José Abraham/0000-0001-8299-5387; Ortiz-León, María Cristina/0000-0003-4953-5076 CR Abdelmalek MF, 2001, AM J GASTROENTEROL, V96, P2711 Abenavoli L, 2014, WORLD J GASTROENTERO, V20, P16831, DOI 10.3748/wjg.v20.i45.16831 Aller R, 2015, EUR REV MED PHARMACO, V19, P3118 Anania C, 2018, WORLD J GASTROENTERO, V24, P2083, DOI 10.3748/wjg.v24.i19.2083 Bedogni G, 2006, BMC GASTROENTEROL, V6, DOI 10.1186/1471-230X-6-33 Billington CJ, 2013, J NUTR, V143, P332, DOI 10.3945/jn.112.168906 Chan R, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0139310 CHAWLA RK, 1990, DRUGS, V40, P98, DOI 10.2165/00003495-199000403-00010 Chen Z, 2020, FREE RADICAL BIO MED, V152, P116, DOI 10.1016/j.freeradbiomed.2020.02.025 CLARK HE, 1970, AM J CLIN NUTR, V23, P731 Collin SM, 2013, ADV CLIN CHEM, V60, P1, DOI 10.1016/B978-0-12-407681-5.00001-5 Díaz LA, 2022, LANCET GASTROENTEROL, V7, P552, DOI 10.1016/S2468-1253(22)00008-5 Eslamparast T, 2015, WORLD J HEPATOL, V7, P204, DOI 10.4254/wjh.v7.i2.204 European Association for the Study of the Liver (EASL), 2016, J Hepatol, V64, P1388, DOI 10.1016/j.jhep.2015.11.004 Farzanegi P, 2019, EUR J SPORT SCI, V19, P994, DOI 10.1080/17461391.2019.1571114 Fedewa MV, 2019, CLIN NUTR, V38, P715, DOI 10.1016/j.clnu.2018.03.014 Floriano DR, 2022, REV BRAS ENFERM, V75 Fraser A, 2008, DIABETOLOGIA, V51, P1616, DOI 10.1007/s00125-008-1049-1 Gepner Y, 2018, CIRCULATION, V137, P1143, DOI 10.1161/CIRCULATIONAHA.117.030501 Harrison SA, 2003, AM J GASTROENTEROL, V98, P2485, DOI 10.1111/j.1572-0241.2003.08699.x Jessri M, 2016, AM J CLIN NUTR, V104, P1378, DOI 10.3945/ajcn.116.132647 Klein EA, 2011, JAMA-J AM MED ASSOC, V306, P1549, DOI 10.1001/jama.2011.1437 Lieber CS, 1999, J HEPATOL, V30, P1155, DOI 10.1016/S0168-8278(99)80274-8 Miglio F, 2000, ARZNEIMITTEL-FORSCH, V50, P722 Miller ER, 2005, ANN INTERN MED, V142, P37, DOI 10.7326/0003-4819-142-1-200501040-00110 Mora SI, 2018, EUR J GASTROEN HEPAT, V30, P893, DOI 10.1097/MEG.0000000000001141 Pervez MA, 2018, TURK J GASTROENTEROL, V29, P170, DOI 10.5152/tjg.2018.17297 Pouwels S, 2022, BMC ENDOCR DISORD, V22, DOI 10.1186/s12902-022-00980-1 Roseland Quyen A., 2019, USDA National Nutrient Database for Standard Reference, Legacy Release Ryan MC, 2013, J HEPATOL, V59, P138, DOI 10.1016/j.jhep.2013.02.012 Sanyal AJ, 2010, NEW ENGL J MED, V362, P1675, DOI 10.1056/NEJMoa0907929 Sayiner M, 2016, BMJ OPEN GASTROENTER, V3, DOI 10.1136/bmjgast-2016-000106 Valerino-Perea S, 2019, NUTRIENTS, V11, DOI 10.3390/nu11112803 Vidal-Cevallos Paulina, 2022, Clin Liver Dis (Hoboken), V19, P68, DOI [10.1002/cld.1167, 10.1002/cld.1167] Worm N, 2020, NUTRIENTS, V12, DOI 10.3390/nu12051316 Zhu FS, 2008, WORLD J GASTROENTERO, V14, P6395, DOI 10.3748/wjg.14.6395 Zúniga MA, 1999, SALUD PUBLICA MEXICO, V41, P110 NR 37 TC 1 Z9 1 U1 3 U2 9 PU ARCHIVOS LATINOAMERICANOS NUTRICION PI CARACAS PA APARTADO 62778 CHACAO, AVENIDA FRANCISCO MIRANDA, CARACAS 1060, VENEZUELA SN 0004-0622 EI 2309-5806 J9 ARCH LATINOAM NUTR JI Arch. Latinoam. Nutr. PD JUN PY 2023 VL 73 IS 2 DI 10.37527/2023.73.2.004 PG 18 WC Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Nutrition & Dietetics GA S3JM0 UT WOS:001070164600004 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Calabrese, FM Celano, G Bonfiglio, C Campanella, A Franco, I Annunziato, A Giannelli, G Osella, AR De Angelis, M AF Calabrese, Francesco Maria Celano, Giuseppe Bonfiglio, Caterina Campanella, Angelo Franco, Isabella Annunziato, Alessandro Giannelli, Gianluigi Osella, Alberto Ruben De Angelis, Maria TI Synergistic Effect of Diet and Physical Activity on a NAFLD Cohort: Metabolomics Profile and Clinical Variable Evaluation SO NUTRIENTS LA English DT Article DE Mediterranean diet; VOCs; NAFLD; liver disease; clinical impacting variables; rotating factor analysis ID FATTY LIVER-DISEASE; ASSOCIATION; PROGRESSION; OIL AB Together with its comorbidities, nonalcoholic fatty liver disease (NAFLD) is likely to rise further with the obesity epidemic. However, the literature's evidence shows how its progression can be reduced by the administration of calorie-restrictive dietary interventions and physical activity regimens. The liver function and the gut microbiota have been demonstrated to be closely related. With the aim of ascertaining the impact of a treatment based on the combination of diet and physical activity (versus physical activity alone), we recruited 46 NAFLD patients who were divided into two groups. As a result, we traced the connection between volatile organic compounds (VOCs) from fecal metabolomics and a set of statistically filtered clinical variables. Additionally, we identified the relative abundances of gut microbiota taxa obtained from 16S rRNA gene sequencing. Statistically significant correlations emerged between VOCs and clinical parameters, as well as between VOCs and gut microbiota taxa. In comparison with a physical activity regimen alone, we disclose how ethyl valerate and pentanoic acid butyl ester, methyl valerate, and 5-hepten-2-one, 6-methyl changed because of the positive synergistic effect exerted by the combination of the Mediterranean diet and physical activity regimens. Moreover, 5-hepten-2-one, 6-methyl positively correlated with Sanguinobacteroides, as well as the two genera Oscillospiraceae-UCG002 and Ruminococcaceae UCG010 genera. C1 [Calabrese, Francesco Maria; Celano, Giuseppe; Annunziato, Alessandro; De Angelis, Maria] Univ Bari Aldo Moro, Dept Soil Plant & Food Sci, I-70126 Bari, Italy. [Bonfiglio, Caterina; Campanella, Angelo; Franco, Isabella; Giannelli, Gianluigi; Osella, Alberto Ruben] IRCCS Res Hosp, Natl Inst Gastroenterol S Bellis, Via Turi 27, I-70013 Castellana Grotte, Italy. C3 Universita degli Studi di Bari Aldo Moro RP Celano, G (通讯作者)，Univ Bari Aldo Moro, Dept Soil Plant & Food Sci, I-70126 Bari, Italy.; Osella, AR (通讯作者)，IRCCS Res Hosp, Natl Inst Gastroenterol S Bellis, Via Turi 27, I-70013 Castellana Grotte, Italy. EM francesco.calabrese@uniba.it; giuseppe.celano@uniba.it; catia.bonfiglio@irccsdebellis.it; angelo.campanella@irccsdebellis.it; isabella.franco@irccsdebellis.it; alessandro.annunziato@uniba.it; gianluigi.giannelli@irccsdebellis.it; arosella@irccsdebellis.it; maria.deangelis@uniba.it RI Celano, Giuseppe/GSO-3402-2022; Annunziato, Alessano/MFI-5685-2025; Calabrese, Francesco Maria/HLH-5706-2023; Osella, Alberto/M-6888-2014; Giannelli, Gianluigi/A-8169-2012 OI Celano, Giuseppe/0000-0002-3805-7681; Annunziato, Alessano/0009-0006-9282-0509; Calabrese, Francesco Maria/0000-0003-0176-7046; De Angelis, Maria/0000-0002-2010-884X; Osella, Alberto/0000-0003-4232-8760; Campanella, Angelo/0000-0002-5044-4625; Giannelli, Gianluigi/0000-0002-5140-8060; FRANCO, ISABELLA/0000-0002-3697-0127; Bonfiglio, Caterina/0000-0002-8650-348X FU Italian Minister of Health FX The study was supported by The Italian Minister of Health RC 2019 D.D.G. n. 748, 11 October 2018 and by Apulia Region-D.G.R. n. 1159, 28 June 2018 and 2019. CR Akyuz U, 2015, SCAND J GASTROENTERO, V50, P341, DOI 10.3109/00365521.2014.983160 Aleryani SL, 2005, CLIN CHIM ACTA, V359, P141, DOI 10.1016/j.cccn.2005.03.038 Byun JS, 2017, BIOMED RES INT, V2017, DOI 10.1155/2017/6862439 Calabrese FM, 2022, NUTRIENTS, V14, DOI 10.3390/nu14091773 Chalasani N, 2018, HEPATOLOGY, V67, P328, DOI [10.1002/hep.29367, 10.1038/s42255-021-00344-4] Chrysavgis L, 2022, WORLD J GASTROENTERO, V28, P310, DOI 10.3748/wjg.v28.i3.310 De Chiara F, 2018, J HEPATOL, V69, P905, DOI 10.1016/j.jhep.2018.06.023 Diniz AB, 2020, JHEP REP, V2, DOI 10.1016/j.jhepr.2020.100117 Nguyen-Khac E, 2018, LANCET GASTROENTEROL, V3, P614, DOI 10.1016/S2468-1253(18)30124-9 Franco I, 2021, NUTRIENTS, V13, DOI 10.3390/nu13010066 Gerber Y, 2021, BMC GASTROENTEROL, V21, DOI 10.1186/s12876-021-01681-0 Hagiwara H, 2005, TETRAHEDRON LETT, V46, P393, DOI 10.1016/j.tetlet.2004.11.120 Han XC, 2020, DIABETES RES CLIN PR, V160, DOI 10.1016/j.diabres.2020.108027 Hasegawa T, 2020, NUTRIENTS, V12, DOI 10.3390/nu12051450 Henao-Mejia J, 2012, NATURE, V482, P179, DOI 10.1038/nature10809 Heymann F, 2016, NAT REV GASTRO HEPAT, V13, P88, DOI 10.1038/nrgastro.2015.200 Higarza SG, 2022, FRONT CELL NEUROSCI, V16, DOI 10.3389/fncel.2022.994404 Honsek C, 2018, DIABETOLOGIA, V61, P1295, DOI 10.1007/s00125-018-4582-6 Hrncir T, 2021, MICROORGANISMS, V9, DOI 10.3390/microorganisms9050957 Ji J, 2023, J CLIN TRANSL HEPATO, V11, P174, DOI 10.14218/JCTH.2022.00136 Juárez-Hernández E, 2018, ANN HEPATOL, V17, P577, DOI 10.5604/01.3001.0012.0920 KAISER HF, 1974, PSYCHOMETRIKA, V39, P31, DOI 10.1007/BF02291575 Kimura M, 2020, J NAT MED-TOKYO, V74, P189, DOI 10.1007/s11418-019-01363-y Lai YS, 2016, J AGR FOOD CHEM, V64, P2062, DOI 10.1021/acs.jafc.5b06159 Li CC, 2018, J FOOD DRUG ANAL, V26, P432, DOI 10.1016/j.jfda.2017.01.008 Lin SZ, 2022, EBIOMEDICINE, V75, DOI 10.1016/j.ebiom.2021.103768 Loomba R, 2017, CELL METAB, V25, P1054, DOI 10.1016/j.cmet.2017.04.001 Lustgarten MS, 2014, J GERONTOL A-BIOL, V69, P717, DOI 10.1093/gerona/glt152 Martínez-Arranz I, 2022, HEPATOLOGY, V76, P1121, DOI 10.1002/hep.32427 Mou Y, 2013, MOLECULES, V18, P15587, DOI 10.3390/molecules181215587 Okanoue T, 2022, HEPATOL RES, V52, P998, DOI 10.1111/hepr.13826 Palomino E, 1996, J NAT PROD, V59, P77, DOI 10.1021/np960012r Petersen MC, 2018, PHYSIOL REV, V98, P2133, DOI 10.1152/physrev.00063.2017 Ren ZG, 2019, GUT, V68, P1014, DOI 10.1136/gutjnl-2017-315084 Schleich FN, 2019, AM J RESP CRIT CARE, V200, P444, DOI 10.1164/rccm.201811-2210OC Semmler G, 2023, CLIN MOL HEPATOL, V29, pS244, DOI 10.3350/cmh.2022.0364 Shin MJ, 2006, ANN NUTR METAB, V50, P115, DOI 10.1159/000090499 Simon TG, 2022, GUT, V71, P1867, DOI 10.1136/gutjnl-2021-325724 Taipale T, 2018, SCI REP-UK, V8, DOI 10.1038/s41598-018-28563-y Tilg H, 2021, NAT METAB, V3, P1596, DOI 10.1038/s42255-021-00501-9 Tutino V, 2018, NUTRIENTS, V10, DOI 10.3390/nu10091299 Visschers RGJ, 2013, CURR OPIN CLIN NUTR, V16, P576, DOI 10.1097/MCO.0b013e32836410a4 Wang SK, 2016, BMJ OPEN, V6, DOI 10.1136/bmjopen-2015-010342 Wu LH, 2020, HEPATOL INT, V14, P652, DOI 10.1007/s12072-020-10081-7 Xie GX, 2016, ONCOTARGET, V7, P19355, DOI 10.18632/oncotarget.8466 Zeybel M, 2022, ADV SCI, V9, DOI 10.1002/advs.202104373 Zhang CC, 2022, CLIN RES HEPATOL GAS, V46, DOI 10.1016/j.clinre.2021.101833 Zhang Q, 2022, FRONT NUTR, V9, DOI 10.3389/fnut.2022.934113 NR 48 TC 5 Z9 6 U1 2 U2 11 PU MDPI PI BASEL PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND EI 2072-6643 J9 NUTRIENTS JI Nutrients PD MAY 25 PY 2023 VL 15 IS 11 AR 2457 DI 10.3390/nu15112457 PG 15 WC Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Nutrition & Dietetics GA I7XP5 UT WOS:001004882700001 PM 37299420 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Liu, L Yin, MY Gao, JW Yu, CY Lin, JX Wu, AR Zhu, JZ Xu, CF Liu, XL AF Liu, Lu Yin, Minyue Gao, Jingwen Yu, Chenyan Lin, Jiaxi Wu, Airong Zhu, Jinzhou Xu, Chunfang Liu, Xiaolin TI Intestinal Barrier Function in the Pathogenesis of Nonalcoholic Fatty Liver Disease SO JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY LA English DT Review DE Nonalcoholic fatty liver disease; Intestinal barrier; Intestinal barrier permeability; Gut-liver axis ID JUNCTIONAL ADHESION MOLECULE; GUT-VASCULAR BARRIER; MEDITERRANEAN DIET; HEPATIC STEATOSIS; PERMEABILITY; ACID; MICROBIOME; STEATOHEPATITIS; MECHANISMS; EXPRESSION AB Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide. The mechanisms involved in NAFLD onset are complicated and multifactorial. Recent literature has indicated that altered intestinal barrier function is related to the occurrence and progression of liver disease. The intestinal barrier is important for absorbing nutrients and electrolytes and for defending against toxins and antigens in the enteric environment. Major mechanisms by which the intestinal barrier influences the development of NAFLD involve the altered epithelial layer, decreased intracellular junction integrity, and increased intestinal barrier permeability. Increased intestinal permeability leads to luminal dysbiosis and allows the translocation of pathogenic bacteria and metabolites into the liver, inducing inflammation, immune response, and hepatocyte injury in NAFLD. Although research has been directed to NAFLD in recent decades, the pathophysiological changes in NAFLD initiation and progression are still not completely understood, and the therapeutic targets remain limited. A deeper understanding on the correlation between NAFLD pathogenesis and intestinal barrier regulation must be attained. Therefore, in this review, the components of the intestinal barrier and their respective functions and disruptions during the progression of NAFLD are discussed. C1 [Liu, Lu; Yin, Minyue; Gao, Jingwen; Yu, Chenyan; Lin, Jiaxi; Wu, Airong; Zhu, Jinzhou; Xu, Chunfang; Liu, Xiaolin] Soochow Univ, Dept Gastroenterol, Affiliated Hosp 1, 188 Shizi St, Suzhou 215006, Jiangsu, Peoples R China. C3 Soochow University - China RP Xu, CF; Liu, XL (通讯作者)，Soochow Univ, Dept Gastroenterol, Affiliated Hosp 1, 188 Shizi St, Suzhou 215006, Jiangsu, Peoples R China. EM xcf601@163.com; lxl55@foxmail.com RI ; jingwen, gao/MSX-1089-2025; Lu, Liu/ODL-9245-2025; Yin, Minyue/GRJ-2214-2022 OI Liu, Xiao-Lin/0000-0003-4560-7589; Lu, Liu/0000-0002-3152-7871; ZHU, JINZHOU/0000-0003-0544-9248 FU National Natural Science Foundation of China [81900508]; Natural Science Foundation of Jiangsu Province [BK20190172]; Livelihood Science and Technology Foundation of Suzhou [SKY2021038] FX This study was supported by the National Natural Science Foundation of China (81900508), the Natural Science Foundation of Jiangsu Province (BK20190172), and Livelihood Science and Technology Foundation of Suzhou (SKY2021038). 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FREEWAY, STE 300, SUGAR LAND, TX 77478 USA SN 2225-0719 EI 2310-8819 J9 J CLIN TRANSL HEPATO JI J. Clin. Transl. Hepatol. PD MAR-APR PY 2023 VL 11 IS 2 BP 452 EP 458 DI 10.14218/JCTH.2022.00089 EA AUG 2022 PG 7 WC Gastroenterology & Hepatology WE Science Citation Index Expanded (SCI-EXPANDED) SC Gastroenterology & Hepatology GA 8O9WY UT WOS:000856124900001 PM 36643028 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Chan, R Wong, VWS Chu, WCW Wong, GLH Li, LS Leung, J Chim, AML Yeung, DKW Sea, MMM Woo, J Chan, FKL Chan, HLY AF Chan, Ruth Wong, Vincent Wai-Sun Chu, Winnie Chiu-Wing Wong, Grace Lai-Hung Li, Liz Sin Leung, Jason Chim, Angel Mei-Ling Yeung, David Ka-Wai Sea, Mandy Man-Mei Woo, Jean Chan, Francis Ka-Leung Chan, Henry Lik-Yuen TI Diet-Quality Scores and Prevalence of Nonalcoholic Fatty Liver Disease: A Population Study Using Proton-Magnetic Resonance Spectroscopy SO PLOS ONE LA English DT Article ID MEDITERRANEAN DIET; INSULIN-RESISTANCE; CHINESE POPULATION; RISK-FACTORS; PATTERN; CONSUMPTION; OVERWEIGHT; STEATOSIS; ADHERENCE; SEVERITY AB Dietary pattern analysis is an alternative approach to examine the association between diet and nonalcoholic fatty liver disease (NAFLD). This study examined the association of two diet-quality scores, namely Diet Quality Index-International (DQI-I) and Mediterranean Diet Score (MDS) with NAFLD prevalence. Apparently healthy Chinese adults (332 male, 465 female) aged 18 years or above were recruited through a population screening between 2008 and 2010 in a cross-sectional population-based study in Hong Kong. DQI-I and MDS, as well as major food group and nutrient intakes were calculated based on dietary data from a food frequency questionnaire. NAFLD was defined as intrahepatic triglyceride content at >= 5% by proton-magnetic resonance spectroscopy. Multivariate logistic regression models were used to examine the association between each diet-quality score or dietary component and prevalent NAFLD with adjustment for potential lifestyle, metabolic and genetic factors. A total of 220 subjects (27.6%) were diagnosed with NAFLD. DQI-I but not MDS was associated with the prevalence of NAFLD. A 10-unit decrease in DQI-I was associated with 24% increase in the likelihood of having NAFLD in the age and sex adjusted model (95% CI: 1.06-1.45, p = 0.009), and the association remained significant when the model was further adjusted for other lifestyle factors, metabolic and genetic factors [OR: 1.26 (95% CI: 1.03-1.54), p = 0.027]. Multivariate regression analyses showed an inverse association of the intake of vegetables and legumes, fruits and dried fruits, as well as vitamin C with the NAFLD prevalence (p<0.05). In conclusion, a better diet quality as characterized by a higher DQI-I and a higher consumption of vegetables, legumes and fruits was associated with a reduced likelihood of having NAFLD in Hong Kong Chinese. C1 [Chan, Ruth; Wong, Vincent Wai-Sun; Chu, Winnie Chiu-Wing; Wong, Grace Lai-Hung; Li, Liz Sin; Chim, Angel Mei-Ling; Sea, Mandy Man-Mei; Woo, Jean; Chan, Francis Ka-Leung; Chan, Henry Lik-Yuen] Chinese Univ Hong Kong, Dept Med & Therapeut, Hong Kong, Hong Kong, Peoples R China. [Chan, Ruth; Sea, Mandy Man-Mei; Woo, Jean] Chinese Univ Hong Kong, Ctr Nutr Studies, Hong Kong, Hong Kong, Peoples R China. [Wong, Vincent Wai-Sun; Wong, Grace Lai-Hung; Chim, Angel Mei-Ling; Chan, Francis Ka-Leung; Chan, Henry Lik-Yuen] Chinese Univ Hong Kong, Inst Digest Dis, Hong Kong, Hong Kong, Peoples R China. [Chu, Winnie Chiu-Wing] Chinese Univ Hong Kong, Dept Imaging & Intervent Radiol, Hong Kong, Hong Kong, Peoples R China. [Leung, Jason] Chinese Univ Hong Kong, Jockey Club Ctr Osteoporosis Care & Control, Hong Kong, Hong Kong, Peoples R China. [Yeung, David Ka-Wai] Chinese Univ Hong Kong, Dept Clin Oncol, Hong Kong, Hong Kong, Peoples R China. C3 Chinese University of Hong Kong; Chinese University of Hong Kong; Chinese University of Hong Kong; Chinese University of Hong Kong; Chinese University of Hong Kong; Chinese University of Hong Kong RP Chan, R (通讯作者)，Chinese Univ Hong Kong, Dept Med & Therapeut, Hong Kong, Hong Kong, Peoples R China. EM ruthchansm@cuhk.edu.hk RI li, liz/MSX-5485-2025; Wong, Vincent/K-3864-2014; Leung, Jason C S/NTQ-3894-2025; Chan, Henry/B-9636-2008; Wong, Grace Lai-Hung/L-8586-2014; Chan, Ruth/K-4995-2014; Chan, Francis KL/F-4851-2010; Woo, Jean/K-2625-2014; Chu, Winnie/F-8449-2014 OI Leung, Jason C S/0000-0003-3382-9096; Wong, Grace Lai-Hung/0000-0002-2863-9389; Chan, Ruth/0000-0002-5725-4066; Chan, Francis KL/0000-0001-7388-2436; Woo, Jean/0000-0001-7593-3081; Chu, Winnie/0000-0003-4962-4132 FU Health and Health Services Research Fund - Government of Hong Kong SAR [07080081]; Centre for Nutritional Studies, under Chinese University of Hong Kong FX The study was supported by funding from the Health and Health Services Research Fund sponsored by the Government of Hong Kong SAR (Reference number 07080081) and the Centre for Nutritional Studies, under the auspices of The Chinese University of Hong Kong. The Centre for Nutritional Studies did have a role in the data collection and analysis. 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Low-grade chronic inflammation contributes to disease progression. Diet has protective effects on hepatic health and inflammatory pathways. The purpose of this review is to systematically review and describe the effects of anti-inflammatory dietary patterns on NAFLD.MethodsThe Cochrane CENTRAL Library, Cumulative Index of Nursing and Allied Health Literature, Embase, MEDLINE and Web of Science databases were searched. A total of 252 records were identified, 7 of which were included in this review. The revised Cochrane risk-of-bias tool was used to conduct a quality assessment for randomised trials. Certainty of evidence was assessed using the grading of recommendations, assessment, development, and evaluation tool.ResultsOf the 7 included studies, 6 were classified as low risk of bias and studies ranged from high to very low certainty of evidence. In the randomised-controlled studies systematically reviewed, either adherence to the Mediterranean, DASH, or FLiO diet was studied, against usual care or energy matched controls, with a total of 255 participants. Anti-inflammatory dietary pattern adherence significantly reduced the severity of most hepatic and inflammatory markers, and secondary outcomes. A minority of outcomes were improved significantly more than controls.ConclusionAnti-inflammatory dietary patterns showed benefits to NAFLD risk factors, severity markers and inflammatory markers compared to the control diet. It is unclear whether reductions in the evaluated parameters are related solely to the anti-inflammatory diet or weight loss resulting from caloric restriction, as improvements in control groups were also evidenced. Current limited body of evidence indicates need for further research including isocaloric dietary patterns, longer interventions, measures of inflammatory markers, and studies including normal-weight subjects to confirm findings at higher certainty.PROSPERO RegistrationCRD42021269382. C1 [Abdallah, Jayden; Assaf, Samantha; Hirani, Vasant] Univ Sydney, Charles Perkins Ctr, Discipline Nutr & Dietet, Sydney, Australia. [Das, Arpita] Univ Sydney, Concord Hlth & Ageing Men Project, Camperdown, Australia. C3 University of Sydney; University of Sydney RP Hirani, V (通讯作者)，Univ Sydney, Charles Perkins Ctr, Discipline Nutr & Dietet, Sydney, Australia. 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J. Nutr. PD JUN PY 2023 VL 62 IS 4 BP 1563 EP 1578 DI 10.1007/s00394-023-03085-0 EA JAN 2023 PG 16 WC Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Nutrition & Dietetics GA G3YO2 UT WOS:000917359600001 PM 36690886 OA Green Submitted, hybrid DA 2026-02-02 ER PT J AU Haigh, L Bremner, S Houghton, D Henderson, E Avery, L Hardy, T Hallsworth, K McPherson, S Anstee, QM AF Haigh, Laura Bremner, Susan Houghton, David Henderson, Elsbeth Avery, Leah Hardy, Timothy Hallsworth, Kate McPherson, Stuart Anstee, Quentin M. TI Barriers and Facilitators to Mediterranean Diet Adoption by Patients With Nonalcoholic Fatty Liver Disease in Northern Europe SO CLINICAL GASTROENTEROLOGY AND HEPATOLOGY LA English DT Article DE MDPS; HDL; Metabolic Liver Disease; Scalable Diet Treatments ID CARDIOVASCULAR-DISEASE; WEIGHT-LOSS; INTERVENTION; ADHERENCE; HEALTH; PREVALENCE; INTERVIEWS; PATTERN; ADULTS AB BACKGROUND & AIMS: Dietary interventions for weight loss are effective therapies for nonalcoholic fatty liver disease (NAFLD). The Mediterranean diet might benefit these patients, but it is not followed consistently in Northern European countries. We examined factors that determine Mediterranean diet adoption and maintenance in a northern European population. METHODS: We used a mixed-methods approach to investigate the effects of a 12-week Mediterranean diet intervention and perceived barriers and facilitators. Nineteen adults with NAFLD were recruited from a tertiary hepatology center in England. Participants were taught behavioral strategies through the provision of shopping lists, meal planners, and recipes; no advice was given on calorie allowances or physical activities. We used the 14-point Mediterranean diet assessment tool to assess dietary intake, based on a small number of foods in servings per day or servings per week, at baseline and after 12 weeks; participants were assigned scores of low (<5 points), moderate (6-9 points), or high (10-14 points). Semistructured interviews were audiorecorded, transcribed, and analyzed using the framework method. RESULTS: Twelve weeks after the dietary advice, Mediterranean diet adoption significantly increased from moderate to high (mean increase, 2.2 points; from 7.6 +/- 2.5 at baseline to 9.8 +/- 2.8 at 12 wk) (P = .006). This increase was associated with a mean reduction in body weight of 2.4 kg (from 99.2 +/- 17.0 kg at baseline to 96.8 +/- 17.5 kg at 12 wk) (P = .001) and increased serum concentrations of high-density lipoprotein cholesterol in 72% of participants (from 1.10 +/- 0.8 at baseline to 1.20 +/- 1.30 vs 1.00 +/- 0.5 at 12 wk) (P = .009). Increased nutrition knowledge and skills, family support, Mediterranean diet promotion in media and clinical settings, and nutritional care facilitated diet changes. Barriers to Mediterranean diet uptake included an obesogenic environment, life stressors, and demand for convenience. Poor understanding of the causes and significance of NAFLD adversely affected readiness to change dietary habits. CONCLUSIONS: In an analysis of patients with NAFLD in the northern United Kingdom, we found a 12-week Mediterranean diet intervention was acceptable and associated with significant reductions in body weight and increased serum levels of high-density lipoprotein. We identified barriers and facilitators that could support appropriate treatment adaptations and guide personalized intervention approaches. C1 [Haigh, Laura; Houghton, David; Henderson, Elsbeth; Avery, Leah; Hardy, Timothy; Hallsworth, Kate; McPherson, Stuart; Anstee, Quentin M.] Newcastle Univ, Liver Res Grp, Inst Cellular Med, Newcastle Upon Tyne, Tyne & Wear, England. [Haigh, Laura; Bremner, Susan; Henderson, Elsbeth; Hardy, Timothy; Hallsworth, Kate; McPherson, Stuart; Anstee, Quentin M.] Reg Liver Unit, Reg Liver Unit, Newcastle Upon Tyne Hosp Natl Hlth Serv Fdn Trust, Newcastle Upon Tyne, Tyne & Wear, England. C3 Newcastle University - UK; Newcastle Upon Tyne Hospitals NHS Foundation Trust RP Anstee, QM (通讯作者)，Newcastle Univ, Inst Cellular Med, Sch Med, 4th Floor,William Leech Bldg,Framlington Pl, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England. EM quentin.anstee@newcastle.ac.uk RI ; Anstee, Quentin M/L-2981-2013 OI Hallsworth, Kate/0000-0002-1860-6970; McPherson, Stuart/0000-0002-5638-2453; Anstee, Quentin M/0000-0002-9518-0088; Hardy, Timothy/0000-0001-9777-9134; Avery, Leah/0000-0003-3578-1209; Haigh, Laura/0000-0002-9229-4127 FU North East of England hub of Allied Health Professions Research Network; Elucidating Pathways of Steatohepatitis consortium - Horizon 2020 Framework Program of the European Union [634413]; Newcastle National Institute for Health Research Biomedical Research Centre; H2020 Societal Challenges Programme [634413] Funding Source: H2020 Societal Challenges Programme; National Institute for Health Research [CAT CL-2013-04-010] Funding Source: researchfish FX This research was supported by the North East of England hub of Allied Health Professions Research Network; the Elucidating Pathways of Steatohepatitis consortium, funded by the Horizon 2020 Framework Program of the European Union under grant agreement 634413; and the Newcastle National Institute for Health Research Biomedical Research Centre. 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Gastroenterol. Hepatol. PD JUN PY 2019 VL 17 IS 7 BP 1364 EP + DI 10.1016/j.cgh.2018.10.044 PG 11 WC Gastroenterology & Hepatology WE Science Citation Index Expanded (SCI-EXPANDED) SC Gastroenterology & Hepatology GA HY9AU UT WOS:000468432400030 PM 30391437 DA 2026-02-02 ER PT J AU Khalatbari-Soltani, S Imamura, F Brage, S Rolfe, ED Griffin, SJ Wareham, NJ Marques-Vidal, P Forouhi, NG AF Khalatbari-Soltani, Saman Imamura, Fumiaki Brage, Soren Rolfe, Emanuella De Lucia Griffin, Simon J. Wareham, Nicholas J. Marques-Vidal, Pedro Forouhi, Nita G. TI The association between adherence to the Mediterranean diet and hepatic steatosis: cross-sectional analysis of two independent studies, the UK Fenland Study and the Swiss CoLaus Study SO BMC MEDICINE LA English DT Article DE Mediterranean diet; Hepatic steatosis ID FATTY LIVER-DISEASE; WEIGHED RECORDS; AMINOTRANSFERASE LEVELS; INSULIN-RESISTANCE; PHYSICAL-ACTIVITY; LIFE-STYLE; POPULATION; VALIDATION; PREVALENCE; INDEX AB Background and aimsThe risk of hepatic steatosis may be reduced through changes to dietary intakes, but evidence is sparse, especially for dietary patterns including the Mediterranean diet. We investigated the association between adherence to the Mediterranean diet and prevalence of hepatic steatosis.MethodsCross-sectional analysis of data from two population-based adult cohorts: the Fenland Study (England, n=9645, 2005-2015) and CoLaus Study (Switzerland, n=3957, 2009-2013). Habitual diet was assessed using cohort-specific food frequency questionnaires. Mediterranean diet scores (MDSs) were calculated in three ways based on adherence to the Mediterranean dietary pyramid, dietary cut-points derived from a published review, and cohort-specific tertiles of dietary consumption. Hepatic steatosis was assessed by abdominal ultrasound and fatty liver index (FLI) in Fenland and by FLI and non-alcoholic fatty liver disease (NAFLD) score in CoLaus. FLI includes body mass index (BMI), waist circumference, gamma-glutamyl transferase, and triglyceride; NAFLD includes diabetes, fasting insulin level, fasting aspartate-aminotransferase (AST), and AST/alanine transaminase ratio. Associations were assessed using Poisson regression.ResultsIn Fenland, the prevalence of hepatic steatosis was 23.9% and 27.1% based on ultrasound and FLI, respectively, and in CoLaus, 25.3% and 25.7% based on FLI and NAFLD score, respectively. In Fenland, higher adherence to pyramid-based MDS was associated with lower prevalence of hepatic steatosis assessed by ultrasound (prevalence ratio (95% confidence interval), 0.86 (0.81, 0.90) per one standard deviation of MDS). This association was attenuated [0.95 (0.90, 1.00)] after adjustment for body mass index (BMI). Associations of similar magnitude were found for hepatic steatosis assessed by FLI in Fenland [0.82 (0.78, 0.86)] and in CoLaus [0.85 (0.80, 0.91)], and these were also attenuated after adjustment for BMI. Findings were similar when the other two MDS definitions were used.ConclusionsGreater adherence to the Mediterranean diet was associated with lower prevalence of hepatic steatosis, largely explained by adiposity. These findings suggest that an intervention promoting a Mediterranean diet may reduce the risk of hepatic steatosis. C1 [Khalatbari-Soltani, Saman; Imamura, Fumiaki; Brage, Soren; Rolfe, Emanuella De Lucia; Griffin, Simon J.; Wareham, Nicholas J.; Forouhi, Nita G.] Univ Cambridge, Sch Clin Med, Med Res Council, Epidemiol Unit, Cambridge CB2 0QQ, England. [Khalatbari-Soltani, Saman; Marques-Vidal, Pedro] CHU Vaudois, Univ Lausanne Hosp, Dept Internal Med, Internal Med, Rue Bugnon 46, CH-1011 Lausanne, Switzerland. C3 UK Research & Innovation (UKRI); Medical Research Council UK (MRC); University of Cambridge; University of Lausanne; Centre Hospitalier Universitaire Vaudois (CHUV) RP Khalatbari-Soltani, S (通讯作者)，Univ Cambridge, Sch Clin Med, Med Res Council, Epidemiol Unit, Cambridge CB2 0QQ, England.; Khalatbari-Soltani, S (通讯作者)，CHU Vaudois, Univ Lausanne Hosp, Dept Internal Med, Internal Med, Rue Bugnon 46, CH-1011 Lausanne, Switzerland. EM saman.khalatbari@gmail.com RI Imamura, Fumiaki/J-1038-2019; Khalatbari-Soltani, Saman/M-7161-2014; Forouhi, Nita/JAC-2361-2023; Brage, Soren/C-6415-2013; Marques-Vidal, Peo/C-9449-2009; Griffin, Simon/K-3106-2013 OI Imamura, Fumiaki/0000-0002-6841-8396; Khalatbari-Soltani, Saman/0000-0001-8437-1906; Forouhi, Nita/0000-0002-5041-248X; Brage, Soren/0000-0002-1265-7355; Marques-Vidal, Peo/0000-0002-4548-8500; Griffin, Simon/0000-0002-2157-4797 FU Medical Research Council Epidemiology Unit [SJAG/004 RG71153]; Wellcome Trust; Medical Research Council [MC_UU_12015/1, MC_UU_12015/5]; NIHR Biomedical Research Centre Cambridge: Nutrition, Diet, and Lifestyle Research Theme [IS-BRC-1215-20014]; GlaxoSmithKline; Faculty of Biology and Medicine of Lausanne; Swiss National Science Foundation [33CSCO-122661, 33CS30-139468, 33CS30-148401, P1LAP3-171805]; Medical Research Council [MC_UU_12015/3, MC_PC_13046, MC_UU_12015/1, MC_UU_12015/5, MC_UU_12015/4, MC_U106179473, MC_UU_12015/2] Funding Source: researchfish; National Institute for Health Research [NF-SI-0515-10119, NF-SI-0617-10149, NF-SI-0512-10135] Funding Source: researchfish; Swiss National Science Foundation (SNF) [P1LAP3_171805] Funding Source: Swiss National Science Foundation (SNF); MRC [MC_PC_13046, MC_UU_12015/4, MC_UU_12015/1, MC_UU_12015/3, MC_UU_12015/5, MC_U106179473, MC_UU_12015/2] Funding Source: UKRI FX The Fenland Study is funded by the Medical Research Council Epidemiology Unit (SJAG/004 RG71153) and the Wellcome Trust. We acknowledge support from Medical Research Council programmes MC_UU_12015/1 and MC_UU_12015/5 and from NIHR Biomedical Research Centre Cambridge: Nutrition, Diet, and Lifestyle Research Theme (IS-BRC-1215-20014). The CoLaus study is supported by research grants from GlaxoSmithKline, the Faculty of Biology and Medicine of Lausanne, and the Swiss National Science Foundation (grants 33CSCO-122661, 33CS30-139468, and 33CS30-148401). SKS supported by the Swiss National Science Foundation (Doc.Mobility number P1LAP3-171805). NJW is an NIHR Senior Investigator. 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PD JAN 24 PY 2019 VL 17 AR 19 DI 10.1186/s12916-019-1251-7 PG 14 WC Medicine, General & Internal WE Science Citation Index Expanded (SCI-EXPANDED) SC General & Internal Medicine GA HI5ZF UT WOS:000456532100001 PM 30674308 OA Green Submitted, Green Published, gold DA 2026-02-02 ER PT J AU Rasoulizadeh, Z Namazi, A Sohouli, MH Rohani, P Hekmatdoost, A Hosseinzadeh, M AF Rasoulizadeh, Zahra Namazi, Abolfazl Sohouli, Mohammad Hassan Rohani, Pejman Hekmatdoost, Azita Hosseinzadeh, Mahdieh TI Association between Baltic sea diet and healthy Nordic diet index with risk of non-alcoholic fatty liver disease: a case-control study SO SCIENTIFIC REPORTS LA English DT Article DE NAFLD; Nordic diet; Baltic sea diet; Chronic diseases; Case-control ID MEDITERRANEAN DIET; METABOLIC SYNDROME; UNITED-STATES; INFLAMMATION; PREVALENCE; ADHERENCE; MARKERS; OBESITY; PROFILE AB Recent evidence shows the beneficial effects of Baltic Sea diet score (BSDS) and healthy Nordic diet index (HNDI) on chronic diseases, however, there is no evidence to investigate them on the risk of non-alcoholic fatty liver disease (NAFLD). The purpose of this study was to investigate the associations between BSDS and HNDI with the risk of NAFLD. In this case-control study, 552 people in good health and 340 people with NAFLD over the age of 18 took part. The evaluation of BSDS and HNDI employed a validated 168-item semi-quantitative food frequency questionnaire (FFQ). Binary logistic regression was used to determine how OBS and NAFLD are related. The mean BSDS and HNDI were 16.00 +/- 2.49 and 11.99 +/- 2.61, respectively. The final model's confounder adjustment revealed that greater HNDI adherence scores gave protection against the occurrence of NAFLD (odds ratio [OR]: 0.42; 95% confidence interval [CI] 0.18-0.98; P for trend = 0.043). In addition, those with the highest BSDS scores had significantly lower risks of developing NAFLD compared to subjects with the lowest scores (OR = 0.48, 95% CI 0.32-0.89; p for trend = 0.003). Our findings showed that following a healthy Nordic diet can significantly prevent the risk of developing NAFLD, and suggest that the highly nutritious components of the Nordic diet are beneficial for the prevention of NAFLD. C1 [Rasoulizadeh, Zahra] Shahid Sadoughi Univ Med Sci, Sch Med, Yazd, Iran. [Namazi, Abolfazl] Iran Univ Med Sci, Hazrat E Rasool Gen Hosp, Dept Internal Med, Tehran, Iran. [Sohouli, Mohammad Hassan] Shahid Beheshti Univ Med Sci, Natl Nutr & Food Technol Res Inst, Fac Nutr & Food Technol, Dept Clin Nutr & Dietet,Student Res Comm, 7 West Arghavan St,Farahzadi Blvd,POB 19395-4741, Tehran 1981619573, Iran. [Sohouli, Mohammad Hassan; Rohani, Pejman] Univ Tehran Med Sci, Pediat Gastroenterol & Hepatol Res Ctr, Childrens Med Ctr, Pediat Ctr Excellence, Tehran, Iran. [Hekmatdoost, Azita] Shahid Beheshti Univ Med Sci, Fac Nutr & Food Technol, Dept Clin Nutr & Dietet, Tehran, Iran. [Hosseinzadeh, Mahdieh] Shahid Sadoughi Univ Med Sci, Sch Publ Hlth, Dept Nutr, Yazd, Iran. C3 Shahid Sadoughi University of Medical Sciences; Iran University of Medical Sciences; Shahid Beheshti University Medical Sciences; Tehran University of Medical Sciences; Shahid Beheshti University Medical Sciences; Shahid Sadoughi University of Medical Sciences RP Sohouli, MH (通讯作者)，Shahid Beheshti Univ Med Sci, Natl Nutr & Food Technol Res Inst, Fac Nutr & Food Technol, Dept Clin Nutr & Dietet,Student Res Comm, 7 West Arghavan St,Farahzadi Blvd,POB 19395-4741, Tehran 1981619573, Iran.; Sohouli, MH (通讯作者)，Univ Tehran Med Sci, Pediat Gastroenterol & Hepatol Res Ctr, Childrens Med Ctr, Pediat Ctr Excellence, Tehran, Iran.; Hosseinzadeh, M (通讯作者)，Shahid Sadoughi Univ Med Sci, Sch Publ Hlth, Dept Nutr, Yazd, Iran. EM mohammadhassansohouli@gmail.com; hoseinzade.mahdie@gmail.com RI Rohani, Pejman/Q-3873-2019; Hekmatdoost, Azita/AGM-6497-2022; hosseinzadeh, mahdieh/R-3531-2019 FU Research & Technology Chancellor of Shahid Beheshti University of Medical Sciences FX We thank the Student Research Committee and the Research & Technology Chancellor of Shahid Beheshti University of Medical Sciences. 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Peddu, Dhiraj Amin, Sahil Elsaid, Mohamed, I Minacapelli, Carlos D. Chandler, Toni-Marie Catalano, Carolyn Rustgi, Vinod K. TI Nonalcoholic Fatty Liver Disease in Lean/Nonobese and Obese Individuals: A Comprehensive Review on Prevalence, Pathogenesis, Clinical Outcomes, and Treatment SO JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY LA English DT Review DE NAFLD; Lean or nonobese nonalcoholic fatty liver disease; Obese nonalcoholic fatty liver disease; Clinical outcomes; Treatment; Incidence; Prevalence; Risk factors ID LIFE-STYLE MODIFICATION; GENOME-WIDE ASSOCIATION; Y GASTRIC BYPASS; BODY-MASS INDEX; INSULIN-RESISTANCE; RISK-FACTORS; MEDITERRANEAN DIET; METABOLIC SYNDROME; NONOBESE PATIENTS; SKELETAL-MUSCLE AB Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease worldwide, with an estimated prevalence of 25% globally. NAFLD is closely associated with metabolic syndrome, which are both becoming increasingly more common with increasing rates of insulin resistance, dyslipidemia, and hypertension. Although NAFLD is strongly associated with obesity, lean or nonobese NAFLD is a relatively new phenotype and occurs in patients without increased waist circumference and with or without visceral fat. Currently, there is limited literature comparing and illustrating the differences between lean/nonobese and obese NAFLD patients with regard to risk factors, pathophysiology, and clinical outcomes. In this review, we aim to define and further delineate different phenotypes of NAFLD and present a comprehensive review on the prevalence, incidence, risk factors, genetic predisposition, and pathophysiology. Furthermore, we discuss and compare the clinical outcomes, such as insulin resistance, dyslipidemia, hypertension, coronary artery disease, mortality, and progression to nonalcoholic steatohepatitis, among lean/nonobese and obese NAFLD patients. Finally, we summarize the most up to date current management of NAFLD, including lifestyle interventions, pharmacologic therapies, and surgical options. C1 [Patel, Ankoor H.; Peddu, Dhiraj; Amin, Sahil; Minacapelli, Carlos D.; Chandler, Toni-Marie; Catalano, Carolyn; Rustgi, Vinod K.] Rutgers Robert Wood Johnson Med Sch, Dept Med, Div Gastroenterol & Hepatol, New Brunswick, NJ 08901 USA. [Patel, Ankoor H.; Peddu, Dhiraj; Amin, Sahil; Minacapelli, Carlos D.; Chandler, Toni-Marie; Catalano, Carolyn; Rustgi, Vinod K.] Rutgers Robert Wood Johnson Med Sch, Ctr Liver Dis & Masses, New Brunswick, NJ 08901 USA. [Elsaid, Mohamed, I] Ohio State Univ, Coll Med, Dept Biomed Informat, Columbus, OH 43210 USA. 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Clin. Transl. Hepatol. PD MAR-APR PY 2023 VL 11 IS 2 BP 502 EP 515 DI 10.14218/JCTH.2022.00204 EA DEC 2022 PG 14 WC Gastroenterology & Hepatology WE Science Citation Index Expanded (SCI-EXPANDED) SC Gastroenterology & Hepatology GA 8O9WY UT WOS:000905542600001 PM 36643037 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Guo, WM Crossland, N Crott, JW AF Guo, Weimin Crossland, Nicholas Crott, Jimmy W. TI Mediterranean diet improves liver health but does not protect against azoxymethane-induced colon tumorigenesis compared to Western diet in A/J mice SO EXPERIMENTAL AND MOLECULAR PATHOLOGY LA English DT Article DE Azoxymethane; Mediterranean diet; Colorectal cancer; Non-alcoholic fatty liver disease (NAFLD) ID COLORECTAL-CANCER; METABOLIC-ACTIVATION; CARCINOGENESIS; INFLAMMATION; CYP2E1; METHYLAZOXYMETHANOL; EXPRESSION; EXTRACTS; MODEL; RISK AB Introduction: Abundant evidence indicates that the Mediterranean (MED) diet pattern is beneficial for health, especially cardiovascular health. Epidemiological evidence indicates that the MED diet also affords protection against colorectal cancer (CRC). To date, preclinical models have only evaluated specific MED diet components and therefore, although supportive, fall short of confirming the chemoprotective capacity of this complex dietary pattern. We sought to address this gap. Method: A/J mice were randomized to receive Western (WRN) or MED diets differing in their fat, protein, and carbohydrate sources. Azoxymethane (AOM) was used to initiate colon tumorigenesis and mice were maintained for 19 weeks after the final dose. Result: Unexpectedly high mortality was observed amongst male mice following the second AOM dose. At the end of the study hepatic Cyp2E1, an enzyme that metabolize AOM, was lower in males than females. Livers from MED diet mice were significantly lighter, had lower histologic Non-Alcoholic Fatty Liver Disease (NAFLD) scores, and contained less triglycerides than WRN mice. Amongst females, serum alanine transaminase (ALT) was also lower in MED than WRN mice. Amongst male mice, those fed MED diet presented with significantly more colonic tumors than those on the WRN diet. Conclusion: In this study male mice displayed elevated sensitivity to AOM-induced hepatotoxicity and mortality than females. In agreement with human and preclinical data, livers of MED-diet-fed mice were healthier than those fed WRN diets. We could not confirm the chemoprotective capacity of the MED diet. Additional studies are required to evaluate the purported anticancer effect of the MED diet. C1 [Guo, Weimin; Crossland, Nicholas; Crott, Jimmy W.] Boston Univ, Chobanian & Avedisian Sch Med, Dept Pathol & Lab Med, Boston, MA 02118 USA. [Crossland, Nicholas] Boston Univ, Comparat Pathol Lab, Natl Emerging Infect Dis Labs, Boston, MA USA. [Crossland, Nicholas] Boston Univ, Chobanian & Avedisian Sch Med, Dept Virol Immunol & Microbiol, Boston, MA USA. C3 Boston University; Boston University; Boston University RP Crott, JW (通讯作者)，Boston Univ, Chobanian & Avedisian Sch Med, Dept Pathol & Lab Med, Boston, MA 02118 USA. EM jcrott@bu.edu RI ; Guo, Weimin/B-3155-2009; Crossland, Nicholas/ACH-0652-2022 OI Crott, Jimmy/0000-0002-3529-8826; Guo, Weimin/0000-0003-4318-7154; FU USDA NIFA [2020-67017-37723]; NIH [S10OD030269] FX This study was funded in part by USDA NIFA grant #2020-67017-37723. This work utilized shared instrumentation funded by the NIH (S10OD030269) . 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Mol. Pathol. PD MAR PY 2025 VL 141 AR 104953 DI 10.1016/j.yexmp.2025.104953 EA FEB 2025 PG 7 WC Pathology WE Science Citation Index Expanded (SCI-EXPANDED) SC Pathology GA X4A9O UT WOS:001424809400001 PM 39919552 OA Green Submitted, gold DA 2026-02-02 ER PT J AU García-Mateo, S Martínez-Domínguez, SJ Gargallo-Puyuelo, CJ Villarino, MTA De La Torre, VL Gallego, B Alfambra, E Gomollón, F AF Garcia-Mateo, Sandra Martinez-Dominguez, Samuel J. Gargallo-Puyuelo, Carla Jerusalen Villarino, Maria Teresa Arroyo De La Torre, Viviana Laredo Gallego, Beatriz Alfambra, Erika Gomollon, Fernando TI Lifestyle Can Exert a Significant Impact on the Development of Metabolic Complications and Quality Life in Patients with Inflammatory Bowel Disease SO NUTRIENTS LA English DT Article DE inflammatory bowel disease; mediterranean diet; physical activity; metabolic syndrome; type 2 diabetes mellitus; metabolic dysfunction-associated steatotic liver disease ID PHYSICAL-ACTIVITY; PREVALENCE; MANAGEMENT; WEIGHT AB Inflammatory bowel diseases (IBDs) are associated with an increased risk of metabolic comorbidities. There is a lack of data regarding the relationship between lifestyle and metabolic diseases in IBD patients. A cross-sectional study on consecutive IBD outpatients was conducted. Adherence to the Mediterranean diet (MD) was assessed using a 14-item questionnaire from the PREDIMED study, and physical activity was evaluated using the GODIN-Leisure score. Body composition was studied based on body mass index and waist-hip ratio (WHR), while quality of life was assessed using a nine-item short questionnaire. Among the 688 evaluated IBD patients, 66% were overweight or obese, 72.7% did not lead an active lifestyle and 70.1% did not adhere to the MD. Metabolic syndrome was associated with age (OR = 1.07, p = 0.019), overweight/obesity (OR = 12.987, p < 0.001) and the inflammatory behavior of Crohn's disease (OR = 6.172, p = 0.001). Type 2 diabetes mellitus or prediabetes was associated with age (OR = 1.063 p = 0.016), overweight/obesity (OR = 3.861, p < 0.001) and the inflammatory behavior of Crohn's disease (OR = 4.716, p = 0.001). Overweight /obesity (OR = 5.494, p < 0.001), a high WHR (OR = 2.564, p = 0.005) and a non-active lifestyle (OR = 2.202, p = 0.0003) were associated with metabolic dysfunction-associated steatotic liver disease. Lifestyle, body composition and not solely systemic inflammation might exert a significant influence on the emergence of metabolic comorbidities such as MASLD, type 2 diabetes mellitus and metabolic syndrome in patients with IBD. C1 [Garcia-Mateo, Sandra; Martinez-Dominguez, Samuel J.; Gargallo-Puyuelo, Carla Jerusalen; Villarino, Maria Teresa Arroyo; De La Torre, Viviana Laredo; Gomollon, Fernando] Lozano Blesa Clin Hosp, Dept Gastroenterol, IBD Unit, Zaragoza 50009, Spain. [Garcia-Mateo, Sandra; Martinez-Dominguez, Samuel J.; Gargallo-Puyuelo, Carla Jerusalen; De La Torre, Viviana Laredo; Gallego, Beatriz; Alfambra, Erika; Gomollon, Fernando] Aragon Hlth Res Inst IIS Aragon, Zaragoza 50009, Spain. [Garcia-Mateo, Sandra; Martinez-Dominguez, Samuel J.; Gargallo-Puyuelo, Carla Jerusalen; Villarino, Maria Teresa Arroyo; Gomollon, Fernando] Univ Zaragoza, Sch Med, Zaragoza 50009, Spain. C3 Lozano Blesa University Clinical Hospital; University of Zaragoza RP García-Mateo, S (通讯作者)，Lozano Blesa Clin Hosp, Dept Gastroenterol, IBD Unit, Zaragoza 50009, Spain.; García-Mateo, S (通讯作者)，Aragon Hlth Res Inst IIS Aragon, Zaragoza 50009, Spain.; García-Mateo, S (通讯作者)，Univ Zaragoza, Sch Med, Zaragoza 50009, Spain. EM sgarciamateo7@gmail.com; samuelmartinez94@hotmail.com; carlajerusalen@hotmail.com; tarroyo.salud.aragon@gmail.com; vlaredodelatorre@gmail.com; bgallego@iisaragon.es; ealfambra.due@gmail.com; fgomollon@gmail.com OI Martínez-Domínguez, Samuel J/0000-0003-0857-8117; Gomollón, Fernando/0000-0003-0076-3529; Arroyo Villarino, María Teresa/0000-0001-8089-4398; García-Mateo, Sana/0000-0002-2670-3922; ALFAMBRA, ERIKA/0000-0003-2834-8204; Gargallo, Carla J/0000-0002-3545-2707 FU Grupo Espanol de Trabajo en Enfermedad de Crohn y Colitis Ulcerosa (GETECCU); Diputacion General de Aragon [DGACOVID-02] FX This research was funded by Grupo Espanol de Trabajo en Enfermedad de Crohn y Colitis Ulcerosa (GETECCU) by a Clinical Grant and Diputacion General de Aragon (DGACOVID-02). CR Aguilar M, 2015, JAMA-J AM MED ASSOC, V313, P1973, DOI 10.1001/jama.2015.4260 Amireault S, 2015, PERCEPT MOTOR SKILL, V120, P604, DOI 10.2466/03.27.PMS.120v19x7 Berthon BS, 2014, NUTR RES, V34, P179, DOI 10.1016/j.nutres.2013.12.006 Bilski J, 2019, BIOMOLECULES, V9, DOI 10.3390/biom9120780 Cabral LS, 2017, FRONT NEUROL, V8, DOI 10.3389/fneur.2017.00460 Chaparro M, 2021, J CLIN MED, V10, DOI 10.3390/jcm10132885 Chicco F, 2021, INFLAMM BOWEL DIS, V27, P1, DOI 10.1093/ibd/izaa097 Dragasevic S, 2020, METAB SYNDR RELAT D, V18, P31, DOI 10.1089/met.2019.0090 Duan D, 2021, ENDOCRIN METAB CLIN, V50, P369, DOI 10.1016/j.ecl.2021.05.002 Estruch R, 2013, NEW ENGL J MED, V368, P1279, DOI 10.1056/NEJMoa1200303 Farraye FA, 2017, AM J GASTROENTEROL, V112, P241, DOI 10.1038/ajg.2016.537 Gatt K, 2019, J CROHNS COLITIS, V13, P686, DOI 10.1093/ecco-jcc/jjy214 George J, 2021, CLIN GASTROENTEROL H, V19, P2025, DOI 10.1016/j.cgh.2021.02.027 Gomollon F, 2017, J CROHNS COLITIS, V11, P3, DOI 10.1093/ecco-jcc/jjw168 Haddad TM, 2017, DIAB MET SYND CLIN R, V11, pS209, DOI 10.1016/j.dsx.2016.12.033 Casanova MJ, 2017, J CROHNS COLITIS, V11, P1430, DOI 10.1093/ecco-jcc/jjx102 Kim MH, 2022, FRONT CARDIOVASC MED, V9, DOI 10.3389/fcvm.2022.811058 Kirchgesner J, 2018, GUT, V67, P1261, DOI 10.1136/gutjnl-2017-314015 Lamb CA, 2019, GUT, V68, pS1, DOI 10.1136/gutjnl-2019-318484 Lomer MCE, 2019, ANN NUTR METAB, V74, P18, DOI 10.1159/000495214 Pringle PL, 2015, INFLAMM BOWEL DIS, V21, P2304, DOI 10.1097/MIB.0000000000000498 Reyes-Farias M, 2021, BIOCHEM PHARMACOL, V192, DOI 10.1016/j.bcp.2021.114723 Rinella ME, 2023, HEPATOLOGY, V78, P1966, DOI 10.1097/HEP.0000000000000520 Rodriguez-Duque JC, 2023, CLIN GASTROENTEROL H, V21, P406, DOI 10.1016/j.cgh.2022.01.039 Romero-Gómez M, 2017, J HEPATOL, V67, P829, DOI 10.1016/j.jhep.2017.05.016 Seminerio JL, 2015, INFLAMM BOWEL DIS, V21, P2857, DOI 10.1097/MIB.0000000000000560 Singh S, 2017, NAT REV GASTRO HEPAT, V14, P110, DOI 10.1038/nrgastro.2016.181 Spekhorst LM, 2014, WORLD J GASTROENTERO, V20, P15374, DOI 10.3748/wjg.v20.i41.15374 Tian J, 2015, OBES REV, V16, P883, DOI 10.1111/obr.12304 Tilg H, 2020, NAT REV GASTRO HEPAT, V17, P387, DOI 10.1038/s41575-020-0316-6 Vogelaar L, 2015, SCAND J GASTROENTERO, V50, P1357, DOI 10.3109/00365521.2015.1046135 WHO Consultation, 2000, WHO TECH REP SER, V894, P1 Wittert G, 2022, REV ENDOCR METAB DIS, V23, P1233, DOI 10.1007/s11154-022-09746-5 Zmora N, 2019, NAT REV GASTRO HEPAT, V16, P35, DOI 10.1038/s41575-018-0061-2 NR 34 TC 12 Z9 13 U1 0 U2 2 PU MDPI PI BASEL PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND EI 2072-6643 J9 NUTRIENTS JI Nutrients PD SEP PY 2023 VL 15 IS 18 AR 3983 DI 10.3390/nu15183983 PG 14 WC Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Nutrition & Dietetics GA T3BT1 UT WOS:001076776700001 PM 37764769 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Kouvari, M Boutari, C Chrysohoou, C Fragkopoulou, E Antonopoulou, S Tousoulis, D Pitsavos, C Panagiotakos, DB Mantzoros, CS AF Kouvari, M. Boutari, C. Chrysohoou, C. Fragkopoulou, E. Antonopoulou, S. Tousoulis, D. Pitsavos, C. Panagiotakos, D. B. Mantzoros, C. S. CA ATTICA Study Investigators TI Mediterranean diet is inversely associated with steatosis and fibrosis and decreases ten-year diabetes and cardiovascular risk in NAFLD subjects: Results from the ATTICA prospective cohort study SO CLINICAL NUTRITION LA English DT Article DE Nutrition; Liver steatosis; Liver fibrosis; Macronutrients; Adipocytokines ID FATTY LIVER-DISEASE; HEPATIC STEATOSIS; NATURAL-HISTORY; KEY PLAYER; ADHERENCE; SEVERITY AB Background and aims: We assessed the association of Mediterranean diet with NAFLD and their interaction in predicting ten-year diabetes onset and first fatal/non-fatal cardiovascular disease (CVD) incidence. Methods: The ATTICA prospective observational study in Athens, Greece included 1,514 men and 1,528 women (> 18 years old) free-of-CVD at baseline. Liver steatosis and fibrosis indices were calculated. Mediterranean diet adherence was assessed through MedDietScore. At the ten-year follow-up visit, CVD evaluation was performed in an a priori specified subgroup of n = 2,020 participants and diabetes onset in n = 1,485 free-of-diabetes participants. Results: MedDietScore was inversely associated with steatosis and fibrosis; e.g. in the case of the TyG index the Odds Ratio (OR) of the 3rd vs. 1st MedDietScore tertile was = 0.53, [95% Confidence Interval (95% CI) (0.29, 0.95)] and the associations persisted in multi-adjusted models. NAFLD predicted incident diabetes prospectively over a ten year period [HR = 1.87, 95% CI (0.75, 4.61)] and the association remained significant only in subjects with low MedDietScore (below median) whereas diabetes onset among subjects with higher MedDietScore was not influenced by NAFLD. Similarly, NAFLD predicted CVD [Hazard Ratio (HR) = 3.01, 95%CI(2.28, 3.95)]; the effect remained significant only in subjects with MedDietScore below median [HR = 1.38, 95% CI (1.00, 1.93)] whereas it was essentially null [HR = 1.00,95% CI (0.38, 2.63)] among subjects with higher score. Mediation analysis revealed that adiponectin and adiponectin-to-leptin ratio were the strongest mediators. Conclusions: We report an inverse association between Mediterranean diet and NAFLD. Mediterranean diet protected against diabetes and CVD prospectively among subjects with NAFLD. (c) 2020 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved. C1 [Kouvari, M.; Fragkopoulou, E.; Antonopoulou, S.; Panagiotakos, D. B.] Harokopio Univ, Sch Hlth Sci & Educ, Dept Nutr & Dietet, Athens, Greece. [Boutari, C.; Mantzoros, C. S.] Harvard Med Sch, Beth Israel Deaconess Med Ctr, Dept Med, Boston, MA 02215 USA. [Panagiotakos, D. B.] Univ Canberra, Fac Hlth, Canberra, ACT, Australia. [Chrysohoou, C.; Tousoulis, D.; Pitsavos, C.] Univ Athens, Sch Med, Cardiol Clin 1, Athens, Greece. [Mantzoros, C. S.] Harvard Med Sch, Boston VA Healthcare Syst, Dept Med, Boston, MA 02115 USA. C3 Harokopio University Athens; Harvard University; Harvard University Medical Affiliates; Beth Israel Deaconess Medical Center; Harvard Medical School; University of Canberra; National & Kapodistrian University of Athens; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; US Department of Veterans Affairs; Veterans Health Administration (VHA); VA Boston Healthcare System RP Mantzoros, CS (通讯作者)，Harvard Med Sch, Boston VA Healthcare Syst, Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA. EM cmantzor@bidmc.harvard.edu RI Mantzoros, Christos/Y-2902-2019; Panagiotakos, Demosthenes/K-8294-2019; Boutari, Chrysoula/ABW-6757-2022; Kouvari, Matina/P-2308-2017; ANTONOPOULOU, SMARAGDI/I-6765-2019 OI Boutari, Chrysoula/0000-0002-0053-2440; Kouvari, Matina/0000-0002-1558-194X; ANTONOPOULOU, SMARAGDI/0000-0002-7071-5920; Chrysohoou, Christina/0000-0002-6340-3996 FU Hellenic Society of Cardiology [HCS2002]; Hellenic Atherosclerosis Society [HAS2003]; Hellenic Atherosclerosis Society; Coherus; Novo Nordisk FX The ATTICA study is supported by research grants from the Hellenic Society of Cardiology [HCS2002] and the Hellenic Atherosclerosis Society [HAS2003]. MsKouvari is also supported by a research grant from the Hellenic Atherosclerosis Society. Dr Mantzoros is shareholder of Coherus, has served as a consultant for Coherus, Novo Nordisk, Genfit and has received grant support through his Institution by Coherus and Novo Nordisk. 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Nutr. PD MAY PY 2021 VL 40 IS 5 BP 3314 EP 3324 DI 10.1016/j.clnu.2020.10.058 PG 11 WC Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Nutrition & Dietetics GA SI3DB UT WOS:000654704700014 PM 33234342 DA 2026-02-02 ER PT J AU Ghaemi, A Hosseini, N Osati, S Naghizadeh, MM Dehghan, A Ehrampoush, E Honarvar, B Homayounfar, R AF Ghaemi, Alireza Hosseini, Narjes Osati, Saeed Naghizadeh, Mohammad Mehdi Dehghan, Azizallah Ehrampoush, Elham Honarvar, Behnam Homayounfar, Reza TI Waist circumference is a mediator of dietary pattern in Non-alcoholic fatty liver disease SO SCIENTIFIC REPORTS LA English DT Article ID MEDITERRANEAN DIET; METABOLIC SYNDROME; VEGETABLE CONSUMPTION; RISK; PREVALENCE; ASSOCIATION; OBESITY; PATHOGENESIS; ADHERENCE; FRUCTOSE AB Non-alcoholic fatty liver disease (NAFLD) is an example of pathological fat accumulation in the liver and one of the major health conditions in the world. This study aimed to examine the independent role of dietary patterns in the development of NAFLD. In a cross-sectional study, 1500 individuals referred to a nutrition clinic were randomly selected, their demographic, anthropometric and blood metabolic indices were obtained, and food frequency questionnaires were completed for them. Liver stiffness was calculated using the NAFLD score formula and fibroscan. The two dominant dietary patterns identified were the "healthy" and "unhealthy dietary patterns". A significant percentage of those with NAFLD (45%) were in the upper quartile of the unhealthy model; however, only 10% had the healthy pattern (p < 0.001). In this study, 32.9 and 13.9% of the healthy and unhealthy participants were in the upper quartile of the healthy diet pattern. Also, it was shown that waist circumference is a strong mediator of dietary patterns and NAFLD relationship, and the indirect effect of diet through abdominal circumference is 28 times greater than the direct effect on NAFLD. The results suggested that healthy and unhealthy dietary patterns are respectively associated with lower-and higher-risk of NAFLD but the role of waist circumference as a mediator deserves more consideration. C1 [Ghaemi, Alireza] Mazandaran Univ Med Sci, Fac Publ Hlth, Dept Basic Sci & Nutr, Hlth Sci Res Ctr, Sari, Iran. [Hosseini, Narjes] Fasa Univ Med Sci, Student Res Comm, Fasa, Iran. [Osati, Saeed] Shahid Beheshti Univ Med Sci, Natl Nutr & Food Technol Res Inst, Fac Nutr Sci & Food Technol, Tehran, Iran. [Naghizadeh, Mohammad Mehdi; Dehghan, Azizallah; Ehrampoush, Elham; Homayounfar, Reza] Fasa Univ Med Sci, Noncommunicable Dis Res Ctr, Fasa, Iran. [Ehrampoush, Elham; Honarvar, Behnam; Homayounfar, Reza] Shiraz Univ Med Sci, Inst Hlth, Hlth Policy Res Ctr, Shiraz, Iran. C3 Mazandaran University of Medical Sciences; Shahid Beheshti University Medical Sciences; Shiraz University of Medical Science RP Homayounfar, R (通讯作者)，Fasa Univ Med Sci, Noncommunicable Dis Res Ctr, Fasa, Iran.; Homayounfar, R (通讯作者)，Shiraz Univ Med Sci, Inst Hlth, Hlth Policy Res Ctr, Shiraz, Iran. EM r_homayounfar@yahoo.com RI Ghaemi, Alireza/J-9577-2016; Honarvar, Behnam/K-1623-2013; Dehghan, Azizallah/ABG-3704-2020; Naghizadeh, Mohammad Mehdi/O-4889-2017; Homayounfar, Reza/L-8813-2017 OI Dehghan, Azizallah/0000-0002-7345-0796; Ehrampoush, Elham/0000-0002-6395-3621; Naghizadeh, Mohammad Mehdi/0000-0001-5562-103X; Homayounfar, Reza/0000-0001-5398-9519 CR Abenavoli L, 2014, WORLD J GASTROENTERO, V20, P16831, DOI 10.3748/wjg.v20.i45.16831 Alavian S. 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Trovato, G. M. Ragusa, A. Martines, G. F. Tonzuso, A. Pirri, C. Buccheri, M. A. Trovato, F. M. TI Non-alcoholic fatty liver disease (NAFLD) and MTHFR 1298A > C gene polymorphism SO EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES LA English DT Article DE Homocysteine; Fatty liver; Mediterranean diet; Genetic MTHFR polymorphism; Insulin resistance; Obesity ID CHRONIC HEPATITIS-C; METHYLENETETRAHYDROFOLATE REDUCTASE POLYMORPHISM; COLORECTAL-CANCER RISK; INSULIN-RESISTANCE; MEDITERRANEAN DIET; ALCOHOL-CONSUMPTION; C677T POLYMORPHISM; STEATOSIS; FOLATE; ASSOCIATION AB INTRODUCTION: Non-Alcoholic Fatty Liver Disease (NAFLD) is related to unhealthy habits, mainly to unfavorable dietary profiles. MTHFR gene encodes MethyleneTetraHydroFolate Reductase, a regulatory enzyme whose polymorphisms are associated with hyperhomocysteinemia. Among polymorphisms, C677T, a thermolabile form, but not A1298C, thermostable, was associated with fatty liver and insulin resistance. AIM: to investigate if NAFLD, in subjects referred for nutritional assessment and counselling, has any difference of prevalence and severity when associated with isolated MTHFR A1298C polymorphism and hyperhomocysteinemia. PATIENTS AND METHODS: 94 subjects, age 55.65 +/- 15.43 years, BMI 27.88 +/- 5.17 kg/m(2), 26 with MTHFR Wild type genotype (1298AA) and 68 with MTHFRA1298C single polymorphism were studied: of them, 35 were homozygous (MTHFR1298CC), 33 were heterozygous (MHTFR 1298AC). Insulin resistance was assessed by HOMA-IR, NAFLD by UltraSound Brigh-Liver-Score (BLS). RESULTS: MTHFR subgroups (wild and A1298C single polymorphism) were not different for age, gender, dietary profile and BMI. In NAFLD, MTHFR 1298AC (heterozygous) vs. homozygous wild genotype (MTHFR 1298AA) patients had more severe NAFLD (BLS: 1.12 +/- 1.14 vs. 0.54 +/- 0.76, p < 0.029), greater insulin resistance (HOMA 3.20 +/- 2.35 vs. 2.12 +/- 1.12; p < 0.036), higher AST and gammaGT. CONCLUSIONS: MTHFR1298AC gene heterozygous polymorphisms can be weakly predictive for NAFLD severity. This mutation occurs frequently in populations with low prevalence of overall mortality and of atherosclerosis-associated disease: it could have maintained and maintain its persistence by an heterozygosis advantage mechanism, within significant adherence to healthy nutritional profiles. Interactions of nutrition, genetics and health are a part of the aging process throughout the life span and a greater consideration to the genetic characteristics of populations and individuals is warranted. C1 [Catalano, D.; Trovato, G. M.; Tonzuso, A.; Pirri, C.; Buccheri, M. A.; Trovato, F. M.] Univ Catania, Dept Med & Pediat Sci, Catania, Italy. [Ragusa, A.; Buccheri, M. A.] AOU & Policlin, Catania, Italy. [Martines, G. F.] AOU & Policlin, Internal & Emergency Med Dept, Catania, Italy. C3 University of Catania RP Trovato, FM (通讯作者)，Univ Catania, Dept Med & Pediat Sci, Catania, Italy. 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Rev. Med. Pharmacol. Sci. PD JAN PY 2014 VL 18 IS 2 BP 151 EP 159 PG 9 WC Pharmacology & Pharmacy WE Science Citation Index Expanded (SCI-EXPANDED) SC Pharmacology & Pharmacy GA AA9UC UT WOS:000331437400002 PM 24488901 DA 2026-02-02 ER PT J AU Saeed, N Nadeau, B Shannon, C Tincopa, M AF Saeed, Naba Nadeau, Brian Shannon, Carol Tincopa, Monica TI Evaluation of Dietary Approaches for the Treatment of Non-Alcoholic Fatty Liver Disease: A Systematic Review SO NUTRIENTS LA English DT Review DE non-alcoholic fatty liver disease; hepatology; nutrition; weight loss ID MEDITERRANEAN DIET; HEPATIC STEATOSIS; WEIGHT-LOSS; LIFE-STYLE; INDIVIDUALS; OBESITY AB Lifestyle interventions, namely optimizing nutrition and increasing physical activity, remain the cornerstone of therapy for non-alcoholic fatty liver disease (NAFLD), as this can lead to the significant improvement or resolution of disease. The optimal nutritional approach to treat NAFLD remains unclear. The aim of this systematic review is to evaluate the effectiveness of different nutritional patterns on hepatic, metabolic, and weight-loss endpoints. MEDLINE via PubMed, Embase, Scopus, and Google Scholar were searched. Randomized trials of dietary interventions alone for adults with NAFLD were selected. Two authors independently reviewed articles, to select eligible studies, and performed data abstraction. Six studies, representing 317 patients, were included. The participants had a median age of 46, mean body mass index (BMI) 31.5 and were 64.3% male. The mean study duration was 16.33 +/- 8.62 weeks. Reduction in hepatic steatosis (HS) was statistically significant in 3/5 Mediterranean Diet (MD), one low-carbohydrate, one intermittent fasting (IF) and 1/2 low fat (LF) diet interventions. A total of 3/5 studies using MD, 1/2 LF interventions, and the one IF intervention demonstrated significant reductions in weight. In conclusion, there appears to be most data in support of MD-based interventions, though further randomized trials are needed to assess comparative effectiveness for NAFLD. C1 [Saeed, Naba; Nadeau, Brian; Tincopa, Monica] Univ Michigan Hlth Syst, Dept Internal Med, Div Gastroenterol & Hepatol, Ann Arbor, MI 48109 USA. [Shannon, Carol] Taubman Hlth Sci Lib, Ann Arbor, MI 48109 USA. C3 University of Michigan System; University of Michigan RP Tincopa, M (通讯作者)，Univ Michigan Hlth Syst, Dept Internal Med, Div Gastroenterol & Hepatol, Ann Arbor, MI 48109 USA. EM nasaeed@med.umich.edu; brnadeau@med.umich.edu; cshannon@umich.edu; tincopa@med.umich.edu RI ; Shannon, Carol/AAH-8004-2020; Tincopa, Monica/AAK-7187-2021 OI Saeed, Naba/0000-0003-2438-6107; Shannon, Carol/0000-0003-3193-6963; FU AASLD CTORA grant FX This research received no external funding. MT has received research funding through the AASLD CTORA grant. 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We also examined whether self-efficacy exerted a moderating role in these associations. QoL (SF-12), social support (MSPSS), depressive symptoms (HADS), self-efficacy (GSE), physical activity (IPAQ) and diet (MEDAS) were evaluated in 413 biopsy-proven NAFLD patients. Mediation and moderated mediation models were conducted using the SPSS PROCESS v3.5 macro. Results showed that depressive symptoms mediated the relationship between physical QoL and adherence to physical activity (indirect effect = 6.248, CI = 1.917-10.727), as well as the relationship between social support and adherence to diet (indirect effect = 0.148, CI = 0.035-0.275). Self-efficacy also moderated the indirect effects of QoL and social support on therapeutic adherence through depressive symptoms. Specifically, the higher self-efficacy was, the lower the negative impact on the NAFLD patient's mental health. In conclusion, self-efficacy is defined as a protective factor for therapeutic adherence by NAFLD patients with a psychosocial risk profile. Self-efficacy should, therefore, be a main psychological target in future multidisciplinary NAFLD approaches. C1 [Funuyet-Salas, Jesus; Martin-Rodriguez, Agustin; Perez-San-Gregorio, Maria Angeles] Univ Seville, Dept Personal Assessment & Psychol Treatment, Fac Psychol, Seville 41018, Spain. [Romero-Gomez, Manuel] Univ Seville, UCM Digest Dis & Ciberehd, Virgen Rocio Univ Hosp, Inst Biomed Seville, Seville 41013, Spain. C3 University of Sevilla; CIBER - Centro de Investigacion Biomedica en Red; CIBEREHD; Consejo Superior de Investigaciones Cientificas (CSIC); University of Sevilla; CSIC-JA-USE - Instituto de Biomedicina de Sevilla (IBIS); Virgen del Rocio University Hospital RP Funuyet-Salas, J (通讯作者)，Univ Seville, Dept Personal Assessment & Psychol Treatment, Fac Psychol, Seville 41018, Spain. EM jfunuyet1@us.es; amartinr@us.es; anperez@us.es; mromerogomez@us.es RI Romero-Gómez, Manuel/L-8030-2014; Pérez San Gregorio, Ángeles/AEF-7621-2022; Funuyet-Salas, Jesús/W-5332-2018; Martín Rodríguez, Agustín/JWO-4382-2024 OI Romero-Gómez, Manuel/0000-0001-8494-8947; Pérez San Gregorio, Ángeles/0000-0002-1308-5002; Funuyet-Salas, Jesús/0000-0002-4133-140X; Martín Rodríguez, Agustín/0000-0001-8497-5910 FU FEDER/Ministry of Science and Innovation-State Secretariat for Research (FEDER/Ministerio de Ciencia e Innovacion-Agencia Estatal de Investigacion) [PSI2017-83365-P]; Ministry of Education and Professional Training (Ministerio de Educacion y Formacion Profesional) [FPU16/03146]; Gilead Sciences, Inc. FX This research was funded by FEDER/Ministry of Science and Innovation-State Secretariat for Research (FEDER/Ministerio de Ciencia e Innovacion-Agencia Estatal de Investigacion), project PSI2017-83365-P; Ministry of Education and Professional Training (Ministerio de Educacion y Formacion Profesional), project FPU16/03146; Gilead Sciences, Inc., unrestricted grant. 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Clin. Med. PD MAY PY 2021 VL 10 IS 10 AR 2208 DI 10.3390/jcm10102208 PG 16 WC Medicine, General & Internal WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI) SC General & Internal Medicine GA SI6OO UT WOS:000654947800001 PM 34065216 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Farias, C Cisternas, C Gana, JC Alberti, G Echeverría, F Videla, LA Mercado, L Muñoz, Y Valenzuela, R AF Farias, Camila Cisternas, Camila Gana, Juan Cristobal Alberti, Gigliola Echeverria, Francisca Videla, Luis A. Mercado, Lorena Munoz, Yasna Valenzuela, Rodrigo TI Dietary and Nutritional Interventions in Nonalcoholic Fatty Liver Disease in Pediatrics SO NUTRIENTS LA English DT Review DE pediatric NAFLD; exercise; eating patterns; polyunsaturated fatty acids; vitamins ID MEDITERRANEAN DIET; OBESE CHILDREN; VITAMIN-E; PHYSICAL-ACTIVITY; CLINICAL-TRIAL; ADOLESCENTS; ADHERENCE; ENZYMES; RISK; ASSOCIATION AB Nonalcoholic fatty liver disease (NAFLD) is pediatrics' most common chronic liver disease. The incidence is high in children and adolescents with obesity, which is associated with an increased risk of disease progression. Currently, there is no effective drug therapy in pediatrics; therefore, lifestyle interventions remain the first line of treatment. This review aims to present an updated compilation of the scientific evidence for treating this pathology, including lifestyle modifications, such as exercise and dietary changes, highlighting specific nutritional strategies. The bibliographic review was carried out in different databases, including studies within the pediatric population where dietary and/or nutritional interventions were used to treat NAFLD. Main interventions include diets low in carbohydrates, free sugars, fructose, and lipids, in addition to healthy eating patterns and possible nutritional interventions with n-3 polyunsaturated fatty acids (EPA and DHA), amino acids (cysteine, L-carnitine), cysteamine, vitamins, and probiotics (one strain or multi-strain). Lifestyle changes remain the main recommendation for children with NAFLD. Nevertheless, more studies are required to elucidate the effectiveness of specific nutrients and bioactive compounds in this population. C1 [Farias, Camila; Cisternas, Camila; Mercado, Lorena; Munoz, Yasna] Univ Chile, Fac Med, Dept Nutr, Santiago 8380453, Chile. [Gana, Juan Cristobal; Alberti, Gigliola; Valenzuela, Rodrigo] Pontificia Univ Catolica Chile, Sch Med, Dept Pediat Gastroenterol & Nutr, Div Pediat, Santiago 8330023, Chile. [Echeverria, Francisca] Pontificia Univ Catolica Chile, Nutr & Dietet Sch, Dept Hlth Sci, Santiago 8331150, Chile. [Videla, Luis A.] Univ Chile, Inst Biomed Sci, Fac Med, Mol & Clin Pharmacol Program, Santiago 8380000, Chile. [Munoz, Yasna] Univ Valparaiso, Escuela Nutr & Dietet, Fac Farm, Valparaiso 2360134, Chile. C3 Universidad de Chile; Pontificia Universidad Catolica de Chile; Pontificia Universidad Catolica de Chile; Universidad de Chile; Universidad de Valparaiso RP Valenzuela, R (通讯作者)，Pontificia Univ Catolica Chile, Sch Med, Dept Pediat Gastroenterol & Nutr, Div Pediat, Santiago 8330023, Chile. EM camila.farias.c@uchile.cl; cpcisternas@uc.cl; jcgana@gmail.com; gigialberti@gmail.com; franciscaecheverria@uc.cl; lvidela1944@gmail.com; lorena.mercado@gmail.com; yasnamunoz.nut@gmail.com; rvalenzuelab@uchile.cl RI Alberti, Gigliola/HCI-9021-2022; Mercado-Lopez, Lorena/MTF-5941-2025; Gana, Juan Cristóbal/AAW-3195-2020; Echeverría, Francisca/ISV-5437-2023; Farías Castro, Camila/JAX-7400-2023 OI Alberti, Gigliola/0000-0002-8540-1326; Gana, Juan Cristóbal/0000-0002-0400-2164; Mercado López, Lorena/0009-0007-9813-8815; Echeverría, Francisca/0000-0002-9661-0377; Videla, Luis A/0000-0002-1788-6667; Cisternas Cuevas, Camila/0000-0001-7109-337X; Muñoz Carvajal, Yasna/0000-0003-3554-7543; Valenzuela, Roigo/0000-0001-9298-6142; Farías Castro, Camila/0000-0003-4899-9709 FU Fondo Nacional de Desarrollo Cientifico y Tecnologico (National Fund for Scientific and Technological Research), FONDECYT [1221098] FX This work was supported by Fondo Nacional de Desarrollo Cientifico y Tecnologico (National Fund for Scientific and Technological Research), FONDECYT Grant 1221098 (R.V.). 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Martines, Giuseppe F. Catalano, Daniela Musumeci, Giuseppe Pirri, Clara Trovato, Guglielmo M. TI Echocardiography and NAFLD (non-alcoholic fatty liver disease) SO INTERNATIONAL JOURNAL OF CARDIOLOGY LA English DT Article DE Liver steatosis; Mediterranean diet; Physical activity; Echocardiography; Systolic function; Diastolic function ID HEPATIC TRIGLYCERIDE CONTENT; INSULIN-RESISTANCE; HEART-FAILURE; CARDIOVASCULAR-DISEASE; PHYSICAL-ACTIVITY; FOLLOW-UP; RISK; ATHEROSCLEROSIS; ULTRASOUND; EXERCISE AB Non-alcoholic-fatty-liver-disease (NAFLD) is associated with atherosclerosis, increased cardiovascular risks and mortality. We investigated if, independently of insulin resistance, diet, physical activity and obesity, fatty liver involvement has any relationship with echocardiographic measurements in NAFLD. Patients and methods: 660 NAFLD and 791 non-NAFLD subjects, referred to the same out-patients medical unit for lifestyle-nutritional prescription, were studied. Congestive heart failure, myocardial infarction, malignancies, diabetes mellitus, extreme obesity, underweight-bad-nourished subjects and renal insufficiency were exclusion criteria. Liver steatosis was assessed by Ultrasound-Bright-Liver-Score (BLS), left ventricular ejection fraction (LVEF), trans-mitral E/A doppler ratio (diastolic relaxation) and left ventricular myocardial mass (LVMM/m(2)) by echocardiography. Doppler Renal artery Resistive Index (RRI), insulin resistance (HOMA) and lifestyle profile were also included in the clinical assessment. Results: LVMM/m(2) is significantly greater in NAFLD, 101.62 +/- 34.48 vs. 88.22 +/- 25.61, p < 0.0001 both in men and in women. Ejection fraction is slightly smaller only in men with NAFLD; no significant difference was observed for the E/A ratio. BMI (30.42 +/- 5.49 vs. 24.87 +/- 3.81; p < 0.0001) and HOMA (2.90 +/- 1.70 vs. 1.85 +/- 1.25; p: 0.0001) were significantly greater in NAFLD patients. By Multiple-Linear-Regression, NAFLD and unhealthy dietary profile are associated also in lean non-diabetic subjects with lower systolic function, independently of BMI, dietary profile, physical activity, RRI and insulin resistance. Conclusion: NAFLD may be a meaningful early clue suggestive of diminishing heart function, with similar determining factors. NAFLD is amenable to management and improvement by lifestyle change counseling, addressing a dual target: reducing fatty liver, which is easily monitored by ultrasound, and, independently, maintaining a normal heart function. (C) 2016 Elsevier Ireland Ltd. All rights reserved. C1 [Trovato, Francesca M.; Martines, Giuseppe F.; Catalano, Daniela; Pirri, Clara; Trovato, Guglielmo M.] Univ Catania, Sch Med, Dept Clin & Expt Med, Catania, Italy. [Musumeci, Giuseppe] Univ Catania, Sch Med, Dept Biomed & Biotechnol Sci, Human Anat & Histol Sect, Catania, Italy. C3 University of Catania; University of Catania RP Trovato, GM (通讯作者)，Univ Catania, Dept Clin & Expt Med, AOU Policlin VE, I-95124 Catania, Italy. EM guglielmotrovato@unict.it RI Catalano, Daniela/J-2883-2012; Musumeci, Giuseppe/K-9955-2016 OI Trovato, Guglielmo M/0000-0002-1168-1919; Trovato, Francesca Maria/0000-0002-8048-1646; Musumeci, Giuseppe/0000-0002-8260-8890; Trovato, Guglielmo/0000-0002-3853-2892 CR Bhatia L, 2016, ATHEROSCLEROSIS, V246, P13, DOI 10.1016/j.atherosclerosis.2015.12.028 Brea A, 2013, INT J CARDIOL, V167, P1109, DOI 10.1016/j.ijcard.2012.09.085 Bril F, 2015, J HEPATOL, V62, P405, DOI 10.1016/j.jhep.2014.08.040 Catalano D, 2008, LIVER INT, V28, P1280, DOI 10.1111/j.1478-3231.2008.01742.x Catalano D, 2013, INT J CARDIOL, V168, P4408, DOI 10.1016/j.ijcard.2013.05.034 Catalano D, 2011, HEPATOL INT, V5, P822, DOI 10.1007/s12072-011-9254-2 Cheitlin MD, 2003, J AM COLL CARDIOL, V42, P954, DOI 10.1016/S0735-1097(03)01065-9 Chen CH, 2010, DIGEST DIS SCI, V55, P1752, DOI 10.1007/s10620-009-0935-9 Cobbold JFL, 2012, J GASTROEN HEPATOL, V27, P1281, DOI 10.1111/j.1440-1746.2012.07127.x Dandel M, 2009, INT J CARDIOL, V132, P11, DOI 10.1016/j.ijcard.2008.06.091 Fracanzani AL, 2016, ATHEROSCLEROSIS, V246, P208, DOI 10.1016/j.atherosclerosis.2016.01.016 Khashper A, 2013, INT J CARDIOL, V162, P184, DOI 10.1016/j.ijcard.2011.05.059 Lim S, 2015, INT J CARDIOL, V201, P408, DOI 10.1016/j.ijcard.2015.08.107 Manco M, 2010, ATHEROSCLEROSIS, V209, P463, DOI 10.1016/j.atherosclerosis.2009.10.014 Mathiesen UL, 2002, DIGEST LIVER DIS, V34, P516, DOI 10.1016/S1590-8658(02)80111-6 Oni ET, 2015, AM J CARDIOL, V115, P34, DOI 10.1016/j.amjcard.2014.09.044 Ozturk K, 2015, ATHEROSCLEROSIS, V240, P380, DOI 10.1016/j.atherosclerosis.2015.04.009 Palatini P, 2013, INT J OBESITY, V37, P224, DOI 10.1038/ijo.2012.32 Rijzewijk LJ, 2010, J AM COLL CARDIOL, V56, P225, DOI 10.1016/j.jacc.2010.02.049 Rutter MK, 2008, CIRCULATION, V117, P1003, DOI 10.1161/CIRCULATIONAHA.107.727727 Samsky MD, 2013, J AM COLL CARDIOL, V61, P2397, DOI 10.1016/j.jacc.2013.03.042 Santos RD, 2012, ATHEROSCLEROSIS, V224, P324, DOI 10.1016/j.atherosclerosis.2012.07.018 Singh GK, 2013, J PEDIATR-US, V162, P1160, DOI 10.1016/j.jpeds.2012.11.024 Tamariz L, 2009, CLIN CARDIOL, V32, P327, DOI 10.1002/clc.20496 Thomas EL, 2005, GUT, V54, P122, DOI 10.1136/gut.2003.036566 Treeprasertsuk S, 2012, LIVER INT, V32, P945, DOI 10.1111/j.1478-3231.2011.02753.x Trovato FM, 2015, NETH J MED, V73, P305 Trovato FM, 2015, WORLD J HEPATOL, V7, P2664, DOI 10.4254/wjh.v7.i26.2664 Trovato FM, 2016, LIVER INT, V36, P427, DOI 10.1111/liv.12957 Trovato FM, 2015, CLIN NUTR, V34, P86, DOI 10.1016/j.clnu.2014.01.018 Trovato FM, 2014, EPMA J, V5, DOI 10.1186/1878-5085-5-21 Trovato GM, 2016, ATHEROSCLEROSIS, V249, P228, DOI 10.1016/j.atherosclerosis.2016.02.031 Trovato GM, 2015, ACAD MED, V90, P839, DOI 10.1097/ACM.0000000000000745 Trovato GM, 2013, AM J GASTROENTEROL, V108, P1932, DOI 10.1038/ajg.2013.356 Valentová M, 2013, NUTRITION, V29, P370, DOI 10.1016/j.nut.2012.06.002 VanWagner LB, 2014, ATHEROSCLEROSIS, V235, P599, DOI 10.1016/j.atherosclerosis.2014.05.962 Younossi ZM, 2012, MEDICINE, V91, P319, DOI 10.1097/MD.0b013e3182779d49 NR 37 TC 37 Z9 46 U1 0 U2 10 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0167-5273 EI 1874-1754 J9 INT J CARDIOL JI Int. J. Cardiol. PD OCT 15 PY 2016 VL 221 BP 275 EP 279 DI 10.1016/j.ijcard.2016.06.180 PG 5 WC Cardiac & Cardiovascular Systems WE Science Citation Index Expanded (SCI-EXPANDED) SC Cardiovascular System & Cardiology GA DX9DA UT WOS:000384692600050 PM 27404689 DA 2026-02-02 ER PT J AU Lombardi, R Iuculano, F Pallini, G Fargion, S Fracanzani, AL AF Lombardi, Rosa Iuculano, Federica Pallini, Giada Fargion, Silvia Fracanzani, Anna Ludovica TI Nutrients, Genetic Factors, and Their Interaction in Non-Alcoholic Fatty Liver Disease and Cardiovascular Disease SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES LA English DT Review DE nutrigenomic; fructose; PUFA; micronutrients; cardiovascular disease; NAFLD; diet; epigenetic; PNPLA3; genetic influence ID RANDOMIZED CONTROLLED-TRIAL; CORONARY-HEART-DISEASE; DE-NOVO LIPOGENESIS; WHOLE-GRAIN INTAKE; MYOCARDIAL-INFARCTION; MEDITERRANEAN DIET; RISK-FACTORS; INSULIN SENSITIVITY; HEPATIC STEATOSIS; HIGH-PROTEIN AB Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in Western countries and expose patients to increased risk of hepatic and cardiovascular (CV) morbidity and mortality. Both environmental factors and genetic predisposition contribute to the risk. An inappropriate diet, rich in refined carbohydrates, especially fructose, and saturated fats, and poor in fibers, polyunsaturated fats, and vitamins is one of the main key factors, as well as the polymorphism of patatin-like phospholipase domain containing 3 (PNPLA3 gene) for NAFLD and the apolipoproteins and the peroxisome proliferator-activated receptor (PPAR) family for the cardiovascular damage. Beyond genetic influence, also epigenetics modifications are responsible for various clinical manifestations of both hepatic and CV disease. Interestingly, data are accumulating on the interplay between diet and genetic and epigenetic modifications, modulating pathogenetic pathways in NAFLD and CV disease. We report the main evidence from literature on the influence of both macro and micronutrients in NAFLD and CV damage and the role of genetics either alone or combined with diet in increasing the risk of developing both diseases. Understanding the interaction between metabolic alterations, genetics and diet are essential to treat the diseases and tailoring nutritional therapy to control NAFLD and CV risk. C1 [Lombardi, Rosa; Iuculano, Federica; Pallini, Giada; Fargion, Silvia; Fracanzani, Anna Ludovica] Univ Milan, Dept Pathophysiol & Transplantat, I-20122 Milan, Italy. [Lombardi, Rosa; Fracanzani, Anna Ludovica] Policlin Hosp Milan, Ca Granda IRCCS Fdn, I-20122 Milan, Italy. C3 University of Milan; IRCCS Ca Granda Ospedale Maggiore Policlinico RP Fracanzani, AL (通讯作者)，Univ Milan, Dept Pathophysiol & Transplantat, I-20122 Milan, Italy.; Fracanzani, AL (通讯作者)，Policlin Hosp Milan, Ca Granda IRCCS Fdn, I-20122 Milan, Italy. EM rosa.lombardi@unimi.it; federica.iuculano@unimi.it; giada.pallini@unimi.it; silvia.fargion@unimi.it; anna.fracanzani@unimi.it RI Lombardi, Rosa/AAB-8031-2019; Fracanzani, Anna Ludovica/J-8986-2018 OI Lombardi, Rosa/0000-0001-6958-927X; Fracanzani, Anna Ludovica/0000-0001-5918-0171 FU Ministry of Health [RF 02-358519] FX Ministry of Health RF 02-358519 "Early atherosclerosis in patients with steatosis and with chronic hepatitis C: role of visceral adiposity, procoagulant imbalance and endothelial dysfunction in vascular damage". 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Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND SN 1661-6596 EI 1422-0067 J9 INT J MOL SCI JI Int. J. Mol. Sci. PD NOV PY 2020 VL 21 IS 22 AR 8761 DI 10.3390/ijms21228761 PG 25 WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary WE Science Citation Index Expanded (SCI-EXPANDED) SC Biochemistry & Molecular Biology; Chemistry GA OY3AQ UT WOS:000594122600001 PM 33228237 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Shetty, A Syn, WK AF Shetty, Akshay Syn, Wing-Kin TI Current treatment options for nonalcoholic fatty liver disease SO CURRENT OPINION IN GASTROENTEROLOGY LA English DT Review DE drugs; fatty liver; pharmacologic; weight loss ID INDUCED WEIGHT-LOSS; VITAMIN-E; URSODEOXYCHOLIC ACID; PHYSICAL-ACTIVITY; MEDITERRANEAN DIET; BARIATRIC SURGERY; COFFEE CONSUMPTION; LIFE-STYLE; STEATOHEPATITIS; EXERCISE AB Purpose of review Nonalcoholic fatty liver disease (NAFLD) is the leading cause of liver disease in the United States and is strongly associated to the metabolic syndrome. In this review, we will discuss the evidence behind the current recommendations on lifestyle modifications and available treatment options for NAFLD. Recent findings The unrelenting rise in obesity and diabetes epidemic has led to a large healthcare burden from NAFLD and it is projected to continue to grow over the next two decades. Lifestyle modification that leads to weight loss is effective at treating NAFLD, but these modifications require a multidisciplinary approach for success in the real world. Multiple pharmacologic treatment options have been studied with promising results, but none have been approved for treatment in the United States. Clinical trials are on-going to study further pharmacologic treatment alternatives. Summary NAFLD is the most common chronic liver disease in United States, and an independent risk factor for mortality. Implementation of lifestyle modifications through a multidisciplinary approach and careful selection of patients for pharmacologic interventions will be essential for successful management of NAFLD. C1 [Shetty, Akshay] Univ Calif Los Angeles, Dept Med, Los Angeles, CA 90024 USA. [Syn, Wing-Kin] Med Univ South Carolina, VAMC, Sect Gastroenterol, Charleston, SC 29425 USA. [Syn, Wing-Kin] Med Univ South Carolina, Div Gastroenterol & Hepatol, 30 Courtenay Dr,MSC 702,Room 402, Charleston, SC 29425 USA. [Syn, Wing-Kin] Univ Basque Country, UPV EHU, Fac Med & Nursing, Dept Physiol, Leioa, Bizkaia, Spain. C3 University of California System; University of California Los Angeles; Medical University of South Carolina; Medical University of South Carolina; University of Basque Country RP Syn, WK (通讯作者)，Med Univ South Carolina, Div Gastroenterol & Hepatol, 30 Courtenay Dr,MSC 702,Room 402, Charleston, SC 29425 USA. 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Opin. Gastroenterol. PD MAY PY 2019 VL 35 IS 3 BP 168 EP 176 DI 10.1097/MOG.0000000000000528 PG 9 WC Gastroenterology & Hepatology WE Science Citation Index Expanded (SCI-EXPANDED) SC Gastroenterology & Hepatology GA HX9TH UT WOS:000467750900006 PM 30844893 DA 2026-02-02 ER PT J AU Georgoulis, M Kontogianni, MD Margariti, A Tiniakos, D Fragopoulou, E Zafiropoulou, R Papatheodoridis, G AF Georgoulis, M. Kontogianni, M. D. Margariti, A. Tiniakos, D. Fragopoulou, E. Zafiropoulou, R. Papatheodoridis, G. TI Associations between dietary intake and the presence of the metabolic syndrome in patients with non-alcoholic fatty liver disease SO JOURNAL OF HUMAN NUTRITION AND DIETETICS LA English DT Article DE dietary habits; food groups; insulin resistance; liver steatosis; Mediterranean diet ID WHOLE-GRAIN INTAKE; MEDITERRANEAN DIET; HEPATIC STEATOSIS; STEATOHEPATITIS; OBESITY; CONSUMPTION; ADHERENCE; MORTALITY; SEVERITY; RISK AB BackgroundAlthough dietary habits have been associated with the likelihood of the metabolic syndrome (MetS) in the general population, similar associations in non-alcoholic fatty liver disease (NAFLD) patients have not been explored. The aim of this cross-sectional study was to assess the presence of the MetS and to explore its potential association with dietary habits in a sample of NAFLD patients. MethodsSeventy-three adult patients with recent NAFLD diagnosis based on elevated liver enzyme levels and evidence of hepatic steatosis on ultrasound were enrolled. Participants' habitual food consumption was retrospectively assessed through a food frequency questionnaire and adherence to the Mediterranean diet (MD) was assessed via the Mediterranean Diet Score (MedDietScore). The presence of the MetS was defined as the concomitant presence of at least three of its individual components, according to the criteria proposed by a recent joint statement of several major organisations. ResultsThe MetS was present in 46.5% of the sample, with increased waist circumference values and decreased high-density lipoprotein cholesterol levels being the most prevalent disorders (63% and 88.7%, respectively). Consumption of refined grains [odds ratio (OR)=1.02, 95% confidence interval (CI)=1.00-1.05] and red meat and products (OR=1.10, 95% CI=1.01-1.21) were positively associated with the presence of the MetS, whereas the consumption of whole grains (OR=0.92, 95% CI=0.84-0.99) and MedDietScore (OR=0.87, 95% CI=0.76-0.99) were negatively associated, after adjusting for participants' age, sex, daily energy intake and time spent in sedentary activities. ConclusionsLow refined grain and red meat intake, high whole grain intake and high adherence to the MD were associated with lower odds of the MetS in NAFLD patients. C1 [Georgoulis, M.; Kontogianni, M. D.; Fragopoulou, E.] Harokopio Univ, Sch Hlth Sci & Educ, Dept Nutr & Dietet, Athens, Greece. [Margariti, A.; Zafiropoulou, R.; Papatheodoridis, G.] Univ Athens, Sch Med, Hippokrat Hosp Athens, Dept Internal Med 2, GR-11527 Athens, Greece. [Tiniakos, D.] Univ Athens, Sch Med, Lab Histol & Embryol, Athens 11528, Greece. [Papatheodoridis, G.] Univ Athens, Sch Med, Laiko Hosp Athens, Dept Gastroenterol, GR-11527 Athens, Greece. C3 Harokopio University Athens; National & Kapodistrian University of Athens; National & Kapodistrian University of Athens; National & Kapodistrian University of Athens; Laiko General Hospital RP Kontogianni, MD (通讯作者)，Harokopio Univ, Sch Hlth Sci & Educ, Dept Nutr & Dietet, El Venizelou 70, Kallithea 17671, Greece. EM mkont@hua.gr RI Papatheodoridis, George/A-4603-2008; Tiniakos, Dina/AAA-5708-2020; Georgoulis, Michael/AAO-2167-2021; Kontogianni, Meropi/AAN-6530-2021; Fragopoulou, Elizabeth/AAN-2050-2021 OI Papatheodoridis, George/0000-0002-3518-4060; Georgoulis, Michael/0000-0003-4619-2100; Kontogianni, Meropi/0000-0003-3168-8867; FU Hellenic Foundation of Gastroenterology Nutrition FX This research was supported financially by a research grant from the Hellenic Foundation of Gastroenterology & Nutrition. 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Hum. Nutr. Diet. PD AUG PY 2015 VL 28 IS 4 BP 409 EP 415 DI 10.1111/jhn.12323 PG 7 WC Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Nutrition & Dietetics GA CN4DA UT WOS:000358378400011 PM 25988570 DA 2026-02-02 ER PT J AU Trovato, FM Catalano, D Garozzo, A Martines, GF Pirri, C Trovato, GM AF Trovato, Francesca M. Catalano, Daniela Garozzo, Adriana Martines, G. Fabio Pirri, Clara Trovato, Guglielmo M. TI ADV36 adipogenic adenovirus in human liver disease SO WORLD JOURNAL OF GASTROENTEROLOGY LA English DT Article DE Non-alcoholic fatty liver disease; Human adenovirus 36; Obesity; Insulin resistance; Mediterranean diet; Ultrasound ID LONG-TERM CHANGES; INSULIN-RESISTANCE; GLYCEMIC CONTROL; NUTRITIONAL INTERVENTION; MEDITERRANEAN DIET; HEPATIC STEATOSIS; RESISTIVE INDEX; BRIGHT LIVER; LIFE-STYLE; OBESITY AB Obesity and liver steatosis are usually described as related diseases. Obesity is regarded as exclusive consequence of an imbalance between food intake and physical exercise, modulated by endocrine and genetic factors. Non-alcoholic fatty liver disease (NAFLD), is a condition whose natural history is related to, but not completely explained by over-nutrition, obesity and insulin resistance. There is evidence that environmental infections, and notably adipogenic adenoviruses ( ADV) infections in humans, are associated not only with obesity, which is sufficiently established, but also with allied conditions, such as fatty liver. In order to elucidate the role, if any, of previous ADV36 infection in humans, we investigated association of ADV36-ADV37 seropositivity with obesity and fatty liver in humans. Moreover, the possibility that lifestyle-nutritional intervention in patients with NAFLD and different ADV36 seropositive status, achieves different clinical outcomes on ultrasound bright liver imaging, insulin resistance and obesity was challenged. ADV36 seropositive patients have a more consistent decrease in insulin resistance, fatty liver severity and body weight in comparison with ADV36 seronegative patients, indicating a greater responsiveness to nutritional intervention. These effects were not dependent on a greater pre-interventional body weight and older age. These results imply that no obvious disadvantage - and, seemingly, that some benefit - is linked to ADV36 seropositivity, at least in NAFLD. ADV36 previous infection can boost weight loss and recovery of insulin sensitivity under interventional treatment. (C) 2014 Baishideng Publishing Group Inc. All rights reserved. C1 [Trovato, Francesca M.; Catalano, Daniela; Martines, G. Fabio; Pirri, Clara; Trovato, Guglielmo M.] Univ Catania, Dept Med & Pediat Sci, I-95100 Catania, Italy. [Garozzo, Adriana] Univ Catania, Dept Biomed Sci, I-95100 Catania, Italy. C3 University of Catania; University of Catania RP Trovato, GM (通讯作者)，Univ Catania, Dept Med & Pediat Sci, Ed 4,4th Floor,Via Santa Sofia, I-95100 Catania, Italy. 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Gastroenterol. PD OCT 28 PY 2014 VL 20 IS 40 BP 14706 EP 14716 DI 10.3748/wjg.v20.i40.14706 PG 11 WC Gastroenterology & Hepatology WE Science Citation Index Expanded (SCI-EXPANDED) SC Gastroenterology & Hepatology GA AR9GS UT WOS:000343881800017 PM 25356033 OA Green Submitted, hybrid DA 2026-02-02 ER PT J AU Matsumoto, Y Fujii, H Harima, M Okamura, H Yukawa-Muto, Y Odagiri, N Motoyama, H Kotani, K Kozuka, R Kawamura, E Hagihara, A Uchida-Kobayashi, S Enomoto, M Yasui, Y Habu, D Kawada, N AF Matsumoto, Yoshinari Fujii, Hideki Harima, Mika Okamura, Haruna Yukawa-Muto, Yoshimi Odagiri, Naoshi Motoyama, Hiroyuki Kotani, Kohei Kozuka, Ritsuzo Kawamura, Etsushi Hagihara, Atsushi Uchida-Kobayashi, Sawako Enomoto, Masaru Yasui, Yoko Habu, Daiki Kawada, Norifumi TI Severity of Liver Fibrosis Is Associated with the Japanese Diet Pattern and Skeletal Muscle Mass in Patients with Nonalcoholic Fatty Liver Disease SO NUTRIENTS LA English DT Article DE Japanese diet; nutrition; lifestyle; liver fibrosis; nonalcoholic steatohepatitis; muscle mass ID INSULIN-RESISTANCE; HISTORY QUESTIONNAIRES; MEDITERRANEAN DIET; WEIGHT-LOSS; NAFLD; INDIVIDUALS; POPULATION; STEATOSIS; NUTRITION; FEATURES AB It is not fully clear as to which dietary patterns are associated with the pathogenesis of nonalcoholic fatty liver disease (NAFLD) in Asia. We conducted a cross-sectional study of 136 consecutively recruited patients with NAFLD (49% female, median age 60 years). Severity of liver fibrosis was assessed using the Agile 3+ score, a recently proposed system based on vibration-controlled transient elastography. Dietary status was assessed using the 12-component modified Japanese diet pattern index (mJDI12). Skeletal muscle mass was assessed by bioelectrical impedance. Factors associated with intermediate-high-risk Agile 3+ scores and skeletal muscle mass (75th percentile or higher) were analyzed by multivariable logistic regression. After adjustment for confounders, such as age and sex, the mJDI12 (OR: 0.77; 95% CI: 0.61, 0.99) and skeletal muscle mass (75th percentile or higher) (OR: 0.23; 95% CI: 0.07, 0.77) were significantly associated with intermediate-high-risk Agile 3+ scores. Soybeans and soybean foods were significantly associated with skeletal muscle mass (75th percentile or higher) (OR: 1.02; 95% CI: 1.00, 1.04). In conclusion, the Japanese diet pattern was associated with the severity of liver fibrosis in Japanese patients with NAFLD. Skeletal muscle mass was also associated with the severity of liver fibrosis, and intake of soybeans and soybean foods. C1 [Matsumoto, Yoshinari; Yasui, Yoko; Habu, Daiki] Osaka Metropolitan Univ, Grad Sch Human Life & Ecol, Dept Nutr, 3-7-30 Habikino, Habikino, Osaka 5838555, Japan. [Fujii, Hideki; Yukawa-Muto, Yoshimi; Odagiri, Naoshi; Motoyama, Hiroyuki; Kotani, Kohei; Kozuka, Ritsuzo; Kawamura, Etsushi; Hagihara, Atsushi; Enomoto, Masaru; Kawada, Norifumi] Osaka Metropolitan Univ, Grad Sch Med, Dept Hepatol, 1-4-3 Asahimachi,Abeno Ku, Osaka 5458585, Japan. [Harima, Mika; Okamura, Haruna] Osaka Metropolitan Univ Hosp, Nutr Dept, 1-5-7 Asahimachi,Abeno Ku, Osaka 5458586, Japan. [Uchida-Kobayashi, Sawako] Osaka Metropolitan Univ, Grad Sch Med, Dept Premier Prevent Med, 1-4-3 Asahimachi,Abenoku, Osaka 5458585, Japan. C3 Osaka Metropolitan University RP Fujii, H (通讯作者)，Osaka Metropolitan Univ, Grad Sch Med, Dept Hepatol, 1-4-3 Asahimachi,Abeno Ku, Osaka 5458585, Japan. EM rolahideki@omu.ac.jp RI kawada, norifumi/AAS-1367-2020; ENOMOTO, Masaru/I-3864-2019; Fujii, Hideki/I-1862-2019; Matsumoto, Yoshinari/W-6286-2019; Odagiri, Naoshi/MSX-4852-2025 OI Fujii, Hideki/0000-0003-1267-9623; Matsumoto, Yoshinari/0000-0002-7896-3101; FU Grants-in-Aid for Scientific Research [23K24322] Funding Source: KAKEN CR Albano E, 2005, GUT, V54, P987, DOI 10.1136/gut.2004.057968 Amanat S, 2018, CLIN NUTR, V37, P1210, DOI 10.1016/j.clnu.2017.05.028 Angulo P, 2015, GASTROENTEROLOGY, V149, P389, DOI 10.1053/j.gastro.2015.04.043 Crowder SL, 2021, NUTRIENTS, V13, DOI 10.3390/nu13082886 D'Agostino RB, 1998, STAT MED, V17, P2265, DOI 10.1002/(SICI)1097-0258(19981015)17:19<2265::AID-SIM918>3.0.CO;2-B Davison BA, 2020, J HEPATOL, V73, P1322, DOI 10.1016/j.jhep.2020.06.025 Dulai PS, 2017, HEPATOLOGY, V65, P1557, DOI 10.1002/hep.29085 Fujii H, 2023, CLIN GASTROENTEROL H, V21, P370, DOI 10.1016/j.cgh.2022.01.002 Fujii H, 2016, BMC PUBLIC HEALTH, V16, DOI 10.1186/s12889-016-3053-6 Hashimoto R, 2015, J MED INVESTIG, V62, P177, DOI 10.2152/jmi.62.177 Himoto T, 2020, CAN J GASTROENTEROL, V2020, DOI 10.1155/2020/3576974 Imai T, 2019, J NUTR HEALTH AGING, V23, P717, DOI 10.1007/s12603-019-1219-5 Kamada Y, 2021, J GASTROENTEROL, V56, P1045, DOI 10.1007/s00535-021-01833-9 Kim G, 2018, HEPATOLOGY, V68, P1755, DOI 10.1002/hep.30049 Kobayashi S, 2012, J EPIDEMIOL, V22, P151, DOI 10.2188/jea.JE20110075 Kobayashi S, 2011, PUBLIC HEALTH NUTR, V14, P1200, DOI 10.1017/S1368980011000504 Kolodziejczyk AA, 2019, EMBO MOL MED, V11, DOI 10.15252/emmm.201809302 Koutoukidis DA, 2019, JAMA INTERN MED, V179, P1262, DOI 10.1001/jamainternmed.2019.2248 Lee YH, 2015, J HEPATOL, V63, P486, DOI 10.1016/j.jhep.2015.02.051 Li DY, 2018, BRIT J NUTR, V119, P1220, DOI [10.1017/S0007114518000739, 10.1017/s0007114518000739] Ma JT, 2018, GASTROENTEROLOGY, V155, P107, DOI 10.1053/j.gastro.2018.03.038 Marchesini G., 2016, DIABETOLOGIA, V64, P1388, DOI [10.1016/j.jhep.2016.11.002, DOI 10.1007/S00125-016-3902-Y] Matsumoto Y, 2018, CLIN NUTR, V37, P675, DOI 10.1016/j.clnu.2017.02.011 Moon SS, 2014, ENDOCR J, V61, P61, DOI 10.1507/endoc O'Brien A, 2008, GASTROENTEROLOGY, V134, P1729, DOI 10.1053/j.gastro.2008.02.001 Pennisi G, 2023, CLIN GASTROENTEROL H, V21, P1293, DOI 10.1016/j.cgh.2022.06.013 de Oca APM, 2020, NUTRIENTS, V12, DOI 10.3390/nu12103100 Podszun MC, 2021, REDOX BIOL, V42, DOI 10.1016/j.redox.2021.101937 Powell EE, 2021, LANCET, V397, P2212, DOI 10.1016/S0140-6736(20)32511-3 Ryan MC, 2013, J HEPATOL, V59, P138, DOI 10.1016/j.jhep.2013.02.012 Sanyal AJ, 2023, J HEPATOL, V78, DOI 10.1016/j.jhep.2022.10.034 Sasso M, 2016, ULTRASOUND MED BIOL, V42, P92, DOI 10.1016/j.ultrasmedbio.2015.08.008 Simon TG, 2022, GUT, V71, P1867, DOI 10.1136/gutjnl-2021-325724 Sugawara S, 2018, J OLEO SCI, V67, P599, DOI 10.5650/jos.ess17259 Suzuki N, 2018, J NUTR SCI VITAMINOL, V64, P129, DOI 10.3177/jnsv.64.129 Targher G, 2016, J HEPATOL, V65, P589, DOI 10.1016/j.jhep.2016.05.013 Tomata Y, 2014, J GERONTOL A-BIOL, V69, P843, DOI 10.1093/gerona/glt182 Vilar-Gomez E, 2015, GASTROENTEROLOGY, V149, P367, DOI 10.1053/j.gastro.2015.04.005 Vittinghoff E, 2007, AM J EPIDEMIOL, V165, P710, DOI 10.1093/aje/kwk052 Weickert MO, 2018, J NUTR, V148, P7, DOI 10.1093/jn/nxx008 Younossi ZM, 2021, JHEP REP, V3, DOI 10.1016/j.jhepr.2021.100305 Younossi ZM, 2021, GASTROENTEROLOGY, V160, P912, DOI 10.1053/j.gastro.2020.11.051 Younossi ZM, 2016, HEPATOLOGY, V64, P73, DOI 10.1002/hep.28431 Yu R, 2018, BMC GASTROENTEROL, V18, DOI 10.1186/s12876-018-0776-0 Zelber-Sagi S, 2012, J HEPATOL, V56, P1145, DOI 10.1016/j.jhep.2011.12.011 Zhang S, 2019, NUTR J, V18, DOI 10.1186/s12937-019-0468-9 NR 46 TC 8 Z9 8 U1 1 U2 5 PU MDPI PI BASEL PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND EI 2072-6643 J9 NUTRIENTS JI Nutrients PD MAR PY 2023 VL 15 IS 5 AR 1175 DI 10.3390/nu15051175 PG 12 WC Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Nutrition & Dietetics GA 9V2KR UT WOS:000948228200001 PM 36904174 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Noureddin, M Zelber-Sagi, S Wilkens, LR Porcel, J Boushey, CJ Le Marchand, L Rosen, HR Setiawan, VW AF Noureddin, Mazen Zelber-Sagi, Shira Wilkens, Lynne R. Porcel, Jacqueline Boushey, Carol J. Le Marchand, Loic Rosen, Hugo R. Setiawan, Veronica Wendy TI Diet Associations With Nonalcoholic Fatty Liver Disease in an Ethnically Diverse Population: The Multiethnic Cohort SO HEPATOLOGY LA English DT Article ID PROCESSED MEAT CONSUMPTION; FREE-CHOLESTEROL; AMINOTRANSFERASE ACTIVITY; MEDITERRANEAN DIET; UNITED-STATES; PREVALENCE; MICE; STEATOHEPATITIS; ACCUMULATION; STEATOSIS AB Background and Aims Epidemiological data on dietary risk factors for nonalcoholic fatty liver disease (NAFLD) from population-based studies, particularly in an ethnically diverse population, are scarce. We examined dietary factors in relation to NAFLD risk in African Americans, Japanese Americans, Latinos, native Hawaiians, and whites in the Multiethnic Cohort (MEC). Approach and Results A nested case-control analysis was conducted within the MEC, a large prospective study with >215,000 older adult participants in Hawaii and California. NAFLD was identified using Medicare claims data, and controls were selected among participants without liver disease and individually matched to cases by birth year, sex, ethnicity, and length of Medicare enrollment. Diet was assessed at baseline through a validated quantitative food frequency questionnaire. Diet-NAFLD associations were quantified by odds ratios and 95% confidence intervals using multivariable conditional logistic regression. The study consisted of 2,974 NAFLD cases (518 with cirrhosis, 2,456 without cirrhosis) and 29,474 matched controls. Red meat (P trend = 0.010), processed red meat (P trend = 0.004), poultry (P trend = 0.005), and cholesterol (P trend = 0.005) intakes were positively associated with NAFLD, while dietary fiber intake (P trend = 0.003) was inversely associated with risk. Stronger associations were observed between red meat and cholesterol and NAFLD with cirrhosis than without cirrhosis (P heterogeneity <= 0.014). Conclusions Dietary factors are independently associated with NAFLD and NAFLD-related cirrhosis in a multiethnic population. Decreasing the consumption of cholesterol, red and processed meat, and poultry and increasing consumption of fiber may reduce the risk for NAFLD and related advanced liver disease. C1 [Noureddin, Mazen] Cedars Sinai Med Ctr, Dept Med, Div Gastroenterol & Hepatol, Los Angeles, CA 90048 USA. [Noureddin, Mazen] Cedars Sinai Med Ctr, Comprehens Transplant Ctr, Los Angeles, CA 90048 USA. [Zelber-Sagi, Shira] Univ Haifa, Sch Publ Hlth, Haifa, Israel. [Wilkens, Lynne R.; Boushey, Carol J.; Le Marchand, Loic] Univ Hawaii, Canc Ctr, Epidemiol Program, Honolulu, HI 96822 USA. [Porcel, Jacqueline; Setiawan, Veronica Wendy] Univ Southern Calif, Keck Sch Med, Dept Prevent Med, 1450 Biggy St,Room NRT 1502A, Los Angeles, CA 90033 USA. [Rosen, Hugo R.] Univ Southern Calif, Keck Sch Med, Dept Med, Los Angeles, CA 90033 USA. [Setiawan, Veronica Wendy] Univ Southern Calif, Norris Comprehens Canc Ctr, Los Angeles, CA 90033 USA. C3 Cedars Sinai Medical Center; Cedars Sinai Medical Center; University of Haifa; Cancer Research Center of Hawaii; University of Hawaii System; University of Southern California; University of Southern California; University of Southern California RP Setiawan, VW (通讯作者)，Univ Southern Calif, Keck Sch Med, Dept Prevent Med, 1450 Biggy St,Room NRT 1502A, Los Angeles, CA 90033 USA. EM vsetiawa@usc.edu OI Setiawan, Veronica/0000-0001-9239-5692 FU National Cancer Institute [R01CA228589, U01CA164973]; National Cancer Institute [P30CA071789, R01CA228589, U01CA164973] Funding Source: NIH RePORTER FX Supported by the National Cancer Institute (R01CA228589, to V.W.S.; U01CA164973, to L.L.M.). 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The key concept of NAFLD pathogenesis is excessive triglyceride hepatic accumulation because of an imbalance between free fatty acid influx and efflux. Strong epidemiological, biochemical, and therapeutic evidence supports the premise that the primary pathophysiological derangement in most patients with NAFLD is insulin resistance; thus the association between diabetes and NAFLD is widely recognized in the literature. Since NAFLD is the hepatic manifestation of a metabolic disease, it is also associated with a higher cardio-vascular risk. Conventional B-mode ultrasound is widely adopted as a first-line imaging modality for hepatic steatosis, although magnetic resonance imaging represents the gold standard noninvasive modality for quantifying the amount of fat in these patients. Treatment of NAFLD patients depends on the disease severity, ranging from a more benign condition of nonalcoholic fatty liver to nonalcoholic steatohepatitis. Abstinence from alcohol, a Mediterranean diet, and modification of risk factors are recommended for patients suffering from NAFLD to avoid major cardiovascular events, as per all diabetic patients. In addition, weight loss induced by bariatric surgery seems to also be effective in improving liver features, together with the benefits for diabetes control or resolution, dyslipidemia, and hypertension. Finally, liver transplantation represents the ultimate treatment for severe nonalcoholic fatty liver disease and is growing rapidly as a main indication in Western countries. This review offers a comprehensive multidisciplinary approach to NAFLD, highlighting its connection with diabetes. C1 [Bellini, Maria Irene; Urciuoli, Irene; Lori, Eleonora; Sorrenti, Salvatore; D'Andrea, Vito] Sapienza Univ Rome, Dept Surg Sci, I-00161 Rome, Italy. [Del Gaudio, Giovanni; Polti, Giorgia; Iannetti, Giovanni; Cantisani, Vito] Sapienza Univ Rome, Dept Radiol Sci Oncol & Pathol, I-00161 Rome, Italy. [Gangitano, Elena; Lubrano, Carla] Sapienza Univ Rome, Dept Expt Med, Sect Med Physiopathol Food Sci & Endocrinol, I-00161 Rome, Italy. [Bellini, Maria Irene] Sapienza Univ Rome, Dept Surg Sci, Surgeon, Viale Regina Elena, I-00161 Rome, Italy. C3 Sapienza University Rome; Sapienza University Rome; Sapienza University Rome; Sapienza University Rome RP Bellini, MI (通讯作者)，Sapienza Univ Rome, Dept Surg Sci, Surgeon, Viale Regina Elena, I-00161 Rome, Italy. 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Diabetes PD SEP 15 PY 2022 VL 13 IS 9 BP 668 EP 682 DI 10.4239/wjd.v13.i9.668 PG 15 WC Endocrinology & Metabolism WE Science Citation Index Expanded (SCI-EXPANDED) SC Endocrinology & Metabolism GA 5F3PF UT WOS:000866230300001 PM 36188142 OA Green Submitted, Green Accepted, gold DA 2026-02-02 ER PT J AU Paternostro, R Trauner, M AF Paternostro, Rafael Trauner, Michael TI Current treatment of non-alcoholic fatty liver disease SO JOURNAL OF INTERNAL MEDICINE LA English DT Review DE cirrhosis; fibrosis; non-alcoholic fatty liver disease; non-alcoholic steatohepatitis ID LIFE-STYLE INTERVENTION; BAVENO VI CRITERIA; FIBROSIS STAGE; PORTAL-HYPERTENSION; OBETICHOLIC ACID; NATURAL-HISTORY; SCORING SYSTEM; STEATOHEPATITIS; CIRRHOSIS; RISK AB Non-alcoholic fatty liver disease (NAFLD) comprises a wide spectrum of pathologies ranging from non-alcoholic fatty liver (NAFL), characterized by simple steatosis without inflammation, to non-alcoholic steatohepatitis (NASH), characterized by steatosis of the liver accompanied by inflammation and hepatocyte ballooning, which can lead to advanced fibrosis, cirrhosis and hepatocellular carcinoma. Apart from lifestyle modifications such as weight loss, a Mediterranean diet and physical activity, only a few NAFLD-specific pharmacological treatment options such as Vitamin E and Pioglitazone are considered by current international guidelines. However, recently randomized controlled trials with GLP-1 agonists, FXR and PPAR ligands as well as other agents have been published and may expand the therapeutic armamentarium for NAFLD in the near future. Finally, knowledge about treating complications of end-stage liver disease due to NASH becomes an increasingly important cornerstone in the treatment of the broad disease spectrum of NAFLD. In this review, we summarize currently available and future treatment options for patients with NAFLD that may help internal medicine specialists treat the complete clinical spectrum of this highly prevalent liver disease. C1 [Paternostro, Rafael; Trauner, Michael] Med Univ Vienna, Dept Internal Med 3, Div Gastroenterol & Hepatol, Waehringer Guertel 18-20, A-1090 Vienna, Austria. C3 Medical University of Vienna RP Trauner, M (通讯作者)，Med Univ Vienna, Dept Internal Med 3, Div Gastroenterol & Hepatol, Waehringer Guertel 18-20, A-1090 Vienna, Austria. EM michael.trauner@meduniwien.ac.at RI Paternostro, Rafael/AAU-8209-2020; Trauner, Michael/HCH-4032-2022 OI Paternostro, Rafael/0000-0002-1813-5769; Trauner, Michael/0000-0002-1275-6425 FU Austrian Science Foundation [F7310-B21] FX This work was supported by the grant F7310-B21 from the Austrian Science Foundation (to MT). 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PD AUG PY 2022 VL 292 IS 2 BP 190 EP 204 DI 10.1111/joim.13531 EA JUL 2022 PG 15 WC Medicine, General & Internal WE Science Citation Index Expanded (SCI-EXPANDED) SC General & Internal Medicine GA 3B1PM UT WOS:000821400900001 PM 35796150 OA Green Submitted, hybrid HC Y HP N DA 2026-02-02 ER PT J AU Wang, XC Jin, XQ Li, HC Zhang, XY Chen, X Lu, K Chu, CL AF Wang, Xinchen Jin, Xiaoqian Li, Hancheng Zhang, Xianyu Chen, Xi Lu, Kuan Chu, Chenliang TI Effects of various interventions on non-alcoholic fatty liver disease (NAFLD): A systematic review and network meta-analysis SO FRONTIERS IN PHARMACOLOGY LA English DT Review DE non-alcoholic fatty liver disease; non-alcoholic fatty liver; treatment interventions; systematic review; network meta-analysis ID LIFE-STYLE; MEDITERRANEAN DIET; CURCUMIN; EXERCISE; STEATOHEPATITIS; EFFICACY; PROFILE; LEPTIN; SAFETY; LIPIDS AB Background: With the increasing prevalence of obesity and metabolic syndrome, the incidence of non-alcoholic fatty liver disease (NAFLD) is also increasing. In the next decade, NAFLD may become the main cause of liver transplantation. Therefore, the choice of treatment plan is particularly important. The purpose of this study was to compare several interventions in the treatment of NAFLD to provide some reference for clinicians in selecting treatment methods. Methods: Wesearched Public Medicine (PubMed), Medline, Excerpta Medica Database (Embase), and Cochrane Library from January 2013 to January 2023 to identify randomized controlled trials (RCTs) published in English. The network meta-analysis was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Forty-three studies accounting for a total of 2,969 patients were included, and alanine aminotransferase (ALT), total cholesterol (TC), and low-density lipoprotein cholesterol (LDL) were selected as outcomemeasures for analysis and comparison. Results: We evaluated the results of drug, diet, and lifestyle interventions between the intervention and control groups. Curcumin (CUN) and probiotics (PTC) were selected for medication, the Mediterranean diet (MDED) was selected for special diet (SPD), and various kinds of exercise and lifestyle advice were selected for lifestyle interventions (LFT). The SUCRA was used to rank interventions according to the effect on ALT indicators (SUCRA: PTC 80.3%, SPD 65.2%, LFT 61.4%, PLB 32.8%, CUN 10.2%), TC indicators (SUCRA: PTC 89.4%, SPD 64%, CUN 34%, LFT 36.6%, PLB 17%), and LDL indicators (SUCRA: PTC 84.2%, CUN 69.5%, LFT 51.7%, PLB 30.1%, SPD 14.5%). The pairwise meta-analysis results showed that MDED was significantly better than NT in improving ALT [SMD 1.99, 95% CI (0.38, 3.60)]. In terms of improving TC and LDL, ATS was significantly better than NT [SMD 0.19, 95% CI (0.03, 0.36)] [SMD 0.18, 95% CI (0.01, 0.35)]. Conclusion: Our study showed that PTC is most likely to be the most effective treatment for improving NAFLD indicators. Professional advice on diet or exercise was more effective in treating NAFLD than no intervention. C1 [Wang, Xinchen; Li, Hancheng; Zhang, Xianyu; Lu, Kuan; Chu, Chenliang] Zhaoqing Univ, Coll Food & Pharmaceut Engn, Dept Pharmaceut Engn, Zhaoqing, Guangdong, Peoples R China. [Jin, Xiaoqian] Jinan Univ, Rehabil Med Dept, Zhuhai Hosp, Zhuhai, Peoples R China. [Chen, Xi] Zhejiang Univ, Med Coll, Sch Publ Hlth, Dept Epidemiol & Stat, Hangzhou, Zhejiang, Peoples R China. C3 Zhaoqing University; Jinan University; Zhejiang University RP Chu, CL (通讯作者)，Zhaoqing Univ, Coll Food & Pharmaceut Engn, Dept Pharmaceut Engn, Zhaoqing, Guangdong, Peoples R China. EM 2017010032@zqu.edu.cn RI Zhang, Xianyu/T-9474-2019 FU National Natural Science Foundation of China [82004246]; School of Food and Pharmaceutical Engineering, Zhaoqing University FX Funding This work was supported by National Natural Science Foundation of China (82004246). This study was supported by the School of Food and Pharmaceutical Engineering, Zhaoqing University. 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Pharmacol. PD MAR 29 PY 2023 VL 14 AR 1180016 DI 10.3389/fphar.2023.1180016 PG 14 WC Pharmacology & Pharmacy WE Science Citation Index Expanded (SCI-EXPANDED) SC Pharmacology & Pharmacy GA D6AZ9 UT WOS:000969552400001 PM 37063273 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Perdomo, C D'Ingianna, P Escalada, J Petta, S Romero-Gómez, M Ampuero, J AF Perdomo, Carolina D'Ingianna, Paola Escalada, Javier Petta, Salvatore Romero-Gomez, Manuel Ampuero, Javier TI Nonalcoholic fatty liver disease and the risk of metabolic comorbidities: how to manage in clinical practice SO POLISH ARCHIVES OF INTERNAL MEDICINE-POLSKIE ARCHIWUM MEDYCYNY WEWNETRZNEJ LA English DT Review DE arterial hypertension; dyslipidemia; nonalcoholic fatty liver disease; type 2 diabetes ID TYPE-2 DIABETES-MELLITUS; II RECEPTOR ANTAGONIST; INSULIN-RESISTANCE; ALCOHOL-CONSUMPTION; MEDITERRANEAN DIET; REDUCES FEATURES; CONTROLLED-TRIAL; BLOOD-PRESSURE; WEIGHT-LOSS; STATIN USE AB Nonalcoholic fatty liver disease (NAFLD) is a clinical condition that encompasses various forms of liver damage not caused by chronic alcohol consumption. In the absence of other etiologies, it ranges from ste- atosis to nonalcoholic steatohepatitis and cirrhosis. The prevalence of NAFLD has considerably increased over the last years owing to the current lifestyle (unhealthy diet and sedentarism). Besides, it is associated with metabolic risk factors such as obesity, arterial hypertension, dyslipidemia, and type 2 diabetes. Given the poor prognosis of patients with advanced NAFLD, a practical therapeutic approach is necessary to halt its natural history. However, no licensed drugs have been approved for this purpose to date. Nowadays, we are in a race to find the first drug able to stop the incidence of NAFLD and reverse the disease in patients at more advanced stages. Meanwhile, the management of the NAFLD metabolic overload, including weight loss, cardiovascular protection, insulin sensitization, and lipid reduction, is the only strategy to improve hepatic and extrahepatic outcomes. In this review, we aimed to describe the management of the main metabolic disorders related to NAFLD, such as type 2 diabetes, arterial hypertension, and dyslipidemia. C1 [Perdomo, Carolina; Escalada, Javier] Univ Navarra, Healthcare Res Inst Navarra IdiSNA, Dept Endocrinol & Nutr, Navarra, Spain. [D'Ingianna, Paola; Petta, Salvatore] Univ Palermo, Hepatol, Dipartimento Promoz Salute Materno Infantile Med, PROMISE, Palermo, Italy. [Romero-Gomez, Manuel; Ampuero, Javier] Univ Seville, Virgen Rocio Univ Hosp, Inst Biomed, Seville, Spain. [Romero-Gomez, Manuel; Ampuero, Javier] Ctr Biomed Res Network Liver & Digest Dis CIBEReh, Madrid, Spain. [Escalada, Javier] Ctr Biomed Res Network Physiopathol Obes & Nutr C, Madrid, Spain. C3 University of Navarra; University of Palermo; Virgen del Rocio University Hospital; Consejo Superior de Investigaciones Cientificas (CSIC); University of Sevilla; CSIC-JA-USE - Instituto de Biomedicina de Sevilla (IBIS); CIBER - Centro de Investigacion Biomedica en Red; CIBEREHD RP Ampuero, J (通讯作者)，Virgen Rocio Univ Hosp, Ave Manuel Siurot S-N, Seville 41013, Spain. EM jampuero--ibis@us.es RI ; Romero-Gómez, Manuel/L-8030-2014; Ampuero, Javier/AAI-2582-2019; Escalada, Javier/E-6330-2013 OI Perdomo, Carolina M/0000-0002-5748-0581; Romero-Gómez, Manuel/0000-0001-8494-8947; Escalada, Javier/0000-0001-5877-9465 FU Consejeria de Salud de la Junta de Andalucia [PI--0075--2014]; Spanish Ministry of Economy, Innovation and Competition, Instituto de Salud Carlos III [PI19/01404, PI16/01842, PI17/00535, GLD19/00100] FX This project was partially funded by the "Consejeria de Salud de la Junta de Andalucia" (PI--0075--2014; to JA), the "Spanish Ministry of EconomyYY, Innovation and Competition, Instituto de Salud Carlos III" (PI19/01404, PI16/01842, PI17/00535, and GLD19/00100; to JA). The funders were not involved in the design, analysis, writing, or interpretation of this study. 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Intern. Med. PD NOV 30 PY 2020 VL 130 IS 11 BP 975 EP 985 DI 10.20452/pamw.15510 PG 11 WC Medicine, General & Internal WE Science Citation Index Expanded (SCI-EXPANDED) SC General & Internal Medicine GA PB5IV UT WOS:000596355200009 PM 32666779 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Monserrat-Mesquida, M Quetglas-Llabrés, M Bouzas, C Montemayor, S Mascaró, CM Casares, M Llompart, I Ugarriza, L Martínez, JA Tur, JA Sureda, A AF Monserrat-Mesquida, Margalida Quetglas-Llabres, Magdalena Bouzas, Cristina Montemayor, Sofia Mascaro, Catalina M. Casares, Miguel Llompart, Isabel Ugarriza, Lucia Martinez, J. Alfredo Tur, Josep A. Sureda, Antoni TI Increased Adherence to the Mediterranean Diet after Lifestyle Intervention Improves Oxidative and Inflammatory Status in Patients with Non-Alcoholic Fatty Liver Disease SO ANTIOXIDANTS LA English DT Article DE Mediterranean diet; fatty liver; aerobic capacity; oxidative stress; inflammation ID VIRGIN OLIVE OIL; METABOLIC SYNDROME; PHYSICAL-ACTIVITY; FOLLOW-UP; STRESS; ANTIOXIDANT; MYELOPEROXIDASE; SEVERITY; VALIDITY; OBESITY AB Background: A Mediterranean diet (MedDiet) is recommended as a therapy for non-alcoholic fatty liver disease (NAFLD) because there is no specific pharmacological treatment for this disease. Objective: To assess the relationship between the adherence to the Mediterranean diet and the intrahepatic fat content (IFC), levels of oxidative stress, and inflammation biomarkers after a 6-month lifestyle intervention in NAFLD patients. Methods: Patients diagnosed with NAFLD (n = 60 adults; 40-60 years old) living in the Balearic Islands, Spain, were classified into two groups, according to the adherence to the MedDiet after 6 months of lifestyle intervention. Anthropometry, blood pressure, IFC, maximal oxygen uptake, and pro/antioxidant and inflammatory biomarkers were measured in plasma and in PBMCs before and after the intervention. Results: Reductions in weight, body mass index, IFC, blood pressure levels, circulating glucose, glycosylated hemoglobin, and markers of liver damage-aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma-glutamyl transferase (GGT), and cytokeratin 18 (CK-18)-were observed after the intervention. The highest reductions were observed in the group with the best adherence to the MedDiet. A significant improvement in cardiorespiratory fitness was also observed in the group with a higher adherence. The activities of catalase in plasma and catalase and superoxide dismutase in blood mononuclear cells increased only in the group with a higher adherence, as well as the catalase gene expression in the blood mononuclear cells. The plasma levels of malondialdehyde and myeloperoxidase decreased, and resolvin-D1 increased in both groups after the intervention, whereas interleukin-6 levels decreased only in the group with a higher adherence to the MedDiet. Conclusions: A greater adherence to the MedDiet is related to greater improvements in IFC, cardiorespiratory fitness, and pro-oxidative and proinflammatory status in NAFLD patients after a 6-month nutritional intervention based on the MedDiet. C1 [Monserrat-Mesquida, Margalida; Quetglas-Llabres, Magdalena; Bouzas, Cristina; Montemayor, Sofia; Mascaro, Catalina M.; Llompart, Isabel; Ugarriza, Lucia; Tur, Josep A.; Sureda, Antoni] Univ Balearic Isl IUNICS, Res Grp Community Nutr & Oxidat Stress, Palma De Mallorca 07122, Spain. [Monserrat-Mesquida, Margalida; Quetglas-Llabres, Magdalena; Bouzas, Cristina; Llompart, Isabel; Ugarriza, Lucia; Tur, Josep A.; Sureda, Antoni] Hlth Res Inst Balearic Isl IdISBa, Palma De Mallorca 07120, Spain. [Monserrat-Mesquida, Margalida; Bouzas, Cristina; Montemayor, Sofia; Mascaro, Catalina M.; Llompart, Isabel; Tur, Josep A.; Sureda, Antoni] Inst Salud Carlos III ISCIII, CIBER Fisiopatol Obesidad & Nutr CIBEROBN, Madrid 28029, Spain. [Casares, Miguel] Red Asistencial Juaneda, Radiodiag Serv, Palma De Mallorca 07011, Spain. [Llompart, Isabel] Univ Hosp Son Espases, Clin Anal Serv, Palma De Mallorca 07198, Spain. [Ugarriza, Lucia] Camp Redo Primary Hlth Care Ctr, Palma De Mallorca 07010, Spain. [Martinez, J. Alfredo] CEI UAM CSIC, IMDEA Food, Cardiomet Precis Nutr Program, Madrid 28049, Spain. [Martinez, J. Alfredo] Univ Navarra, Dept Nutr Food Sci & Physiol, Pamplona 31008, Spain. C3 Institut Investigacio Sanitaria Illes Balears (IdISBa); CIBER - Centro de Investigacion Biomedica en Red; CIBEROBN; Hospital Universitari Son Espases; IMDEA Food Institute; Consejo Superior de Investigaciones Cientificas (CSIC); University of Navarra RP Tur, JA (通讯作者)，Univ Balearic Isl IUNICS, Res Grp Community Nutr & Oxidat Stress, Palma De Mallorca 07122, Spain.; Tur, JA (通讯作者)，Hlth Res Inst Balearic Isl IdISBa, Palma De Mallorca 07120, Spain.; Tur, JA (通讯作者)，Inst Salud Carlos III ISCIII, CIBER Fisiopatol Obesidad & Nutr CIBEROBN, Madrid 28029, Spain. EM margalida.monserrat@uib.es; m.quetglas@uib.es; cristina.bouzas@uib.es; sofiamf16@gmail.com; c.mascaro@uib.es; casaresmiguel@gmail.com; isabel.llompart@ssib.es; luciaugarriza@gmail.com; jalfredo.martinez@imdea.org; pep.tur@uib.es; antoni.sureda@uib.es RI Quetglas Llabrés, Maria Magdalena/AAA-4412-2019; Sureda, Antoni/N-9588-2019; Bouzas, Cristina/AAE-2069-2019; Tur, Josep/AAE-5748-2020; Martínez, J./K-8709-2014; Monserrat Mesquida, Margalida/AAB-4773-2019 OI Quetglas Llabrés, Maria Magdalena/0000-0003-4155-7780; Bouzas Velasco, Cristina/0000-0002-1407-8461; Montemayor, Sofía/0000-0001-7833-2118; Tur, Josep/0000-0002-6940-0761; , Antoni/0000-0001-8656-6838; Monserrat Mesquida, Margalida/0000-0002-8856-135X FU Fundacio La Marato TV3 (Spain) project [201630.10]; Instituto de Salud Carlos III through the Fondo de Investigacion para la Salud - European Regional Development Fund [CIBEROBN CB12/03/30038]; IDISBA Grant (FOLIUM); IDISBA Grant (PRIMUS); IDISBA Grant (SYNERGIA); IDISBA Grant (LIBERI); IDISBA grant; FPU PhD grant from the Spanish Ministry of Education; IDISBA pre-doctoral grant FX Fundacio La Marato TV3 (Spain) project ref. 201630.10. Instituto de Salud Carlos III through the Fondo de Investigacion para la Salud (CIBEROBN CB12/03/30038), which are cofunded by the European Regional Development Fund. IDISBA Grants (FOLIUM, PRIMUS, SYNERGIA, and LIBERI). M.Q.-LL. was granted by the IDISBA grant. C.M.M. received an FPU PhD grant from the Spanish Ministry of Education. M.Q.-LL. was granted by the IDISBA pre-doctoral grant. The funding sponsors had no role in the design of the study; in the collection, analyses, or interpretation of the data; in the writing of the manuscript; or in the decision to publish the results. 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A body of research has proposed that olive oil, a basic component of the Mediterranean diet with antioxidant and anti-inflammatory properties, may alleviate metabolic disturbances and retard the progression of NAFLD. We conducted a systematic review and meta-analysis to assess the effectiveness of olive oil intake in people with NAFLD. We systematically searched the major electronic databases (PubMed/MEDLINE, Scopus, Cochrane Central Register of Controlled Trials), as well as grey literature sources, to identify randomized controlled trials (RCTs) investigating the effects of olive oil consumption on biochemical and anthropometric parameters of individuals with NAFLD. The quality of the studies was evaluated using the risk-of-bias tool 2.0 (RoB 2). The mean difference (MD) and the 95% confidence interval (CI) were calculated using fixed-effects and random-effects models. Seven RCTs involving 515 subjects were included in the analysis. In the random-effects model, no statistically significant differences were identified with respect to alanine transaminase (MD = -1.83 IU/L, 95% CI: -5.85, 2.19 IU/L, p = 0.37, I2 = 69%) and aspartate transaminase (MD = -1.65 IU/L, 95% CI: -4.48, 1.17 IU/L, p = 0.25, I2 = 72%) levels or waist circumference values (MD = -0.23 cm, 95% CI: -1.23, 0.76 cm, p = 0.65, I2 = 0%). However, a significant effect on body mass index was observed (MD = -0.57 kg/m2, 95% CI: -1.08, -0.06 kg/m2, p = 0.03, I2 = 51%) for subjects who received olive oil compared to those who received an alternative diet or placebo. The findings of the present meta-analysis suggest a modestly positive impact of olive oil intake on body weight in people with NAFLD. C1 [Tsamos, Georgios] Norfolk & Norwich Univ Hosp NHS Trust, Dept Gastroenterol, Norwich NR4 7UY, England. [Kalopitas, Georgios; Germanidis, Georgios] Aristotle Univ Thessaloniki, Fac Hlth Sci, Div Gastroenterol & Hepatol, Dept Internal Med 1,AHEPA Univ Hosp,Sch Med, Thessaloniki 54636, Greece. [Evripidou, Kleo; Chourdakis, Michail] Aristotle Univ Thessaloniki, Fac Hlth Sci, Sch Med, Lab Hyg Social & Prevent Med & Med Stat, Thessaloniki 54124, Greece. [Vasdeki, Dimitra] Aristotle Univ Thessaloniki, AHEPA Univ Hosp, Dept Internal Med 1, Med Sch,Div Endocrinol & Metab, Thessaloniki 54636, Greece. [Vasdeki, Dimitra] Aristotle Univ Thessaloniki, AHEPA Univ Hosp, Diabet Ctr, Med Sch, Thessaloniki 54636, Greece. [Koufakis, Theocharis] Aristotle Univ Thessaloniki, Hippokrat Gen Hosp, Propedeut Dept Internal Med 2, Thessaloniki 54642, Greece. [Kanavas, Vasileios] Univ Thessaly, Sch Med, Lab Biomath, Larisa 41222, Greece. [Antza, Christina] Aristotle Univ Thessaloniki, Papageorgiou Hosp, Med Sch, Dept Internal Med 3, Thessaloniki 56403, Greece. C3 Norfolk & Norwich University Hospitals NHS Foundation Trust; Aristotle University of Thessaloniki; Ahepa University Hospital; Aristotle University of Thessaloniki; Aristotle University of Thessaloniki; Ahepa University Hospital; Aristotle University of Thessaloniki; Ahepa University Hospital; Aristotle University of Thessaloniki; University of Thessaly; Aristotle University of Thessaloniki; Papageorgiou Hospital RP Tsamos, G (通讯作者)，Norfolk & Norwich Univ Hosp NHS Trust, Dept Gastroenterol, Norwich NR4 7UY, England. EM tsamgeor@gmail.com; giwrgoskalopitas@gmail.com; kleoevripidou@gmail.com; demivs14@gmail.com; thkoyfak@hotmail.com; vasiliskanavas@gmail.com; kris-antza@hotmail.com; georgiosgermanidis@gmail.com; mhourd@gapps.auth.gr RI ; Kalopitas, Georgios/HPC-2449-2023; Koufakis, Theocharis/ABH-8156-2020; GERMANIDIS, GEORGIOS/ABI-3764-2020 OI Antza, Christina/0000-0001-5164-7435; Koufakis, Theocharis/0000-0002-5853-1352; VASDEKI, DIMITRA/0000-0003-0481-344X; GERMANIDIS, GEORGIOS/0000-0001-7985-3118; Chourdakis, Michael/0000-0002-9490-8356; Evripidou, Kleo/0000-0003-3115-3651 CR Abenavoli L, 2018, EXPERT REV GASTROENT, V12, P873, DOI 10.1080/17474124.2018.1503947 Abenavoli L, 2014, WORLD J GASTROENTERO, V20, P16831, DOI 10.3748/wjg.v20.i45.16831 Alvarez-Amor L, 2021, SCI REP-UK, V11, DOI 10.1038/s41598-021-87761-3 Ando Yumi, 2021, Clin Liver Dis (Hoboken), V17, P23, DOI [10.1002/cld.1045, 10.1002/cld.1045] Belfort R, 2006, NEW ENGL J MED, V355, P2297, DOI 10.1056/NEJMoa060326 Biolato M, 2019, WORLD J GASTROENTERO, V25, P509, DOI 10.3748/wjg.v25.i4.509 Brea A, 2017, CLIN INVEST ARTERIOS, V29, P141, DOI 10.1016/j.arteri.2016.06.003 Chalasani N, 2012, HEPATOLOGY, V55, P2005, DOI 10.1002/hep.25762 Cumpston M, 2019, COCHRANE DB SYST REV, DOI 10.1002/14651858.ED000142 de Bock M, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0057622 Di Majo D, 2023, ANTIOXIDANTS-BASEL, V12, DOI 10.3390/antiox12010089 Esposito K, 2011, METAB SYNDR RELAT D, V9, P1, DOI 10.1089/met.2010.0031 Estruch R, 2019, LANCET DIABETES ENDO, V7, pE6, DOI 10.1016/S2213-8587(19)30074-9 FDA, Completes Review of Qualified Health Claim Petition for Oleic Acid and the Risk of Coronary Heart Disease|FDA Feng R, 2015, DIAGN PATHOL, V10, DOI 10.1186/s13000-015-0382-1 Gepner Y, 2019, J HEPATOL, V71, P379, DOI 10.1016/j.jhep.2019.04.013 Guasch-Ferré M, 2022, J AM COLL CARDIOL, V79, P101, DOI 10.1016/j.jacc.2021.10.041 Haigh L, 2022, CLIN NUTR, V41, P1913, DOI 10.1016/j.clnu.2022.06.037 Higgins JPT., COCHRANE HDB SYSTEMA, DOI DOI 10.1002/9781119536604 Higgins Julian P T, 2011, BMJ, V343, pd5928, DOI 10.1136/bmj.d5928 Hozo S., 2005, BMC MED RES METHODOL, V5, P13, DOI [DOI 10.1186/1471-2288-5-13, 10.1186/1471-2288-5-13, DOI 10.1186/1471-2288-5-13)] Kastorini CM, 2011, J AM COLL CARDIOL, V57, P1299, DOI 10.1016/j.jacc.2010.09.073 Kawaguchi T, 2021, SEMIN LIVER DIS, V41, P225, DOI 10.1055/s-0041-1723751 Kruse M, 2020, MOL NUTR FOOD RES, V64, DOI 10.1002/mnfr.202000419 Lama A, 2017, MOL NUTR FOOD RES, V61, DOI 10.1002/mnfr.201600418 Long MT, 2022, GASTROENTEROLOGY, V163, P764, DOI 10.1053/j.gastro.2022.06.023 Ma YW, 2023, J FUNCT FOODS, V109, DOI 10.1016/j.jff.2023.105815 Machado MV, 2014, EXPERT REV GASTROENT, V8, P487, DOI 10.1586/17474124.2014.903798 Manca Camila Sanches, 2023, Evid Based Complement Alternat Med, V2023, P4197955, DOI [10.1155/2023/4197955, 10.1155/2023/4197955] Mancini JG, 2016, AM J MED, V129, P407, DOI 10.1016/j.amjmed.2015.11.028 Marakis G, 2021, NUTRIENTS, V13, DOI 10.3390/nu13113709 Marchesini G, 2003, HEPATOLOGY, V37, P917, DOI 10.1053/jhep.2003.50161 Marchesini G, 2016, J HEPATOL, V64, P1388, DOI 10.1016/j.jhep.2015.11.004 Marjot T, 2023, GUT, V72, P1607, DOI 10.1136/gutjnl-2023-329998 Milano A, 2022, HUM NUTR METAB, V30, DOI 10.1016/j.hnm.2022.200175 Moosavian SP, 2020, CLIN NUTR ESPEN, V35, P40, DOI 10.1016/j.clnesp.2019.10.008 National Guideline Centre (UK), 2016, National Guideline Centre (UK)-National Institute for Health and Clinical Excellence NG49. 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Silva Junior, Wellington S. Valerio, Cynthia M. TI NAFLD as a continuum: from obesity to metabolic syndrome and diabetes SO DIABETOLOGY & METABOLIC SYNDROME LA English DT Review DE NAFLD; NASH; Fatty liver; Obesity; Metabolic syndrome; Diabetes ID FATTY LIVER-DISEASE; MAGNETIC-RESONANCE ELASTOGRAPHY; PLACEBO-CONTROLLED TRIAL; Y GASTRIC BYPASS; IMPROVES HEPATIC STEATOSIS; SIMPLE NONINVASIVE INDEX; LIFE-STYLE MODIFICATION; NONALCOHOLIC STEATOHEPATITIS; WEIGHT-LOSS; MEDITERRANEAN DIET AB BackgroundThe prevalence of non-alcoholic fatty liver disease (NAFLD) has been increasing rapidly. It is nowadays recognized as the most frequent liver disease, affecting a quarter of global population and regularly coexisting with metabolic disorders such as type 2 diabetes, hypertension, obesity, and cardiovascular disease. In a more simplistic view, NAFLD could be defined as an increase in liver fat content, in the absence of secondary cause of steatosis. In fact, the clinical onset of the disease is a much more complex process, closely related to insulin resistance, limited expandability and dysfunctionality of adipose tissue. A fatty liver is a main driver for a new recognized liver-pancreatic alpha -cell axis and increased glucagon, contributing to diabetes pathophysiology.Main textThis review will focus on the clinical and pathophysiological connections between NAFLD, insulin resistance and type 2 diabetes. We reviewed non-invasive methods and several scoring systems for estimative of steatosis and fibrosis, proposing a multistep process for NAFLD evaluation. We will also discuss treatment options with a more comprehensive view, focusing on the current available therapies for obesity and/or type 2 diabetes that impact each stage of NAFLD.ConclusionThe proper understanding of NAFLD spectrum-as a continuum from obesity to metabolic syndrome and diabetes-may contribute to the early identification and for establishment of targeted treatment. C1 [Godoy-Matos, Amelio F.; Valerio, Cynthia M.] Pontifical Catholic Univ Rio Janeiro PUC Rio, Metab Dept, Inst Estadual Diabet & Endocrinol IEDE, BR-20211340 Rio De Janeiro, RJ, Brazil. [Silva Junior, Wellington S.] Fed Univ Maranhao UFMA, Ctr Nat Human Hlth & Technol Sci, Fac Med, Endocrinol Discipline, BR-65200000 Pinheiro, MA, Brazil. C3 Universidade Federal do Maranhao RP Godoy-Matos, AF (通讯作者)，Pontifical Catholic Univ Rio Janeiro PUC Rio, Metab Dept, Inst Estadual Diabet & Endocrinol IEDE, BR-20211340 Rio De Janeiro, RJ, Brazil. 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Metab. Syndr. PD JUL 14 PY 2020 VL 12 IS 1 AR 60 DI 10.1186/s13098-020-00570-y PG 20 WC Endocrinology & Metabolism WE Science Citation Index Expanded (SCI-EXPANDED) SC Endocrinology & Metabolism GA MQ8MR UT WOS:000553147500001 PM 32684985 OA Green Submitted, gold HC Y HP N DA 2026-02-02 ER PT J AU Hannah, WN Harrison, SA AF Hannah, William N., Jr. Harrison, Stephen A. TI Lifestyle and Dietary Interventions in the Management of Nonalcoholic Fatty Liver Disease SO DIGESTIVE DISEASES AND SCIENCES LA English DT Review DE Nonalcoholic fatty liver disease; Weight loss; Exercise; Probiotics ID MEDITERRANEAN DIET; WEIGHT-LOSS; VITAMIN-E; PHYSICAL-ACTIVITY; CARDIOVASCULAR-DISEASE; COFFEE CONSUMPTION; LOW-CARBOHYDRATE; BODY-WEIGHT; STEATOHEPATITIS; FRUCTOSE AB NAFLD is the leading cause of chronic liver disease in the Western world with an estimated prevalence of 20-30 %. Lifestyle interventions targeted at weight loss through dietary interventions and exercise are the most effective treatment, but only a minority of patients are able to achieve and sustain the necessary intervention targets. Weight loss of 3-5 % has been associated with a reduction of hepatic steatosis while weight loss of a parts per thousand yen5-7 % has correlated with resolution of NASH in some studies. Greater reductions in weight loss (a parts per thousand yen10 %) may improve hepatic fibrosis. In the absence of weight loss, no specific diet has demonstrated superiority. Physical activity can improve hepatic steatosis and metabolic indices even without weight loss. Diet coupled with exercise can produce significant weight loss and may improve histologic components of the NAFLD activity score. While formal guidelines for diet and exercise in NAFLD are lacking, adherence to diet and exercise recommendations similar to those from the American Diabetes Association for diabetic care seems reasonable. Dietary supplementation with vitamin E in non-diabetics with biopsy-proven NASH has been shown to improve NAFLD activity score. The role for other macronutrients, micronutrients, antioxidants, and probiotics in the treatment of NAFLD remains limited. C1 [Hannah, William N., Jr.] San Antonio Mil Med Ctr, Dept Med, JBSA Ft Sam Houston, 3551 Roger Brooke Dr, San Antonio, TX 78234 USA. [Harrison, Stephen A.] San Antonio Mil Med Ctr, Div Gastroenterol, JBSA Ft Sam Houston, 3551 Roger Brooke Dr, San Antonio, TX 78234 USA. C3 Brooke Army Medical Center; Brooke Army Medical Center RP Harrison, SA (通讯作者)，San Antonio Mil Med Ctr, Div Gastroenterol, JBSA Ft Sam Houston, 3551 Roger Brooke Dr, San Antonio, TX 78234 USA. 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PD MAY PY 2016 VL 61 IS 5 SI SI BP 1365 EP 1374 DI 10.1007/s10620-016-4153-y PG 10 WC Gastroenterology & Hepatology WE Science Citation Index Expanded (SCI-EXPANDED) SC Gastroenterology & Hepatology GA DK1JH UT WOS:000374667800015 PM 27052013 DA 2026-02-02 ER PT J AU Mohseni, T Farhangi, MA Farajnia, S Khoshbaten, M Ajourlou, E Kakaei, F AF Mohseni, Tatemeh Farhangi, Mahdieh Abbasalizad Farajnia, Safar Khoshbaten, Manouchehr Ajourlou, Elham Kakaei, Farzad TI ADHERENCE TO MEDITERRANEAN NUTRITION PATTERN IN PATIENTS WITH NON-ALCOHOLIC FATTY LIVER DISEASE: RELATIONSHIP WITH METABOLIC RISK FACTORS AND-UCP2-866G/A GENE POLYMORPHISMS SO CURRENT TOPICS IN NUTRACEUTICAL RESEARCH LA English DT Article DE -866G/A polymorphism; Med-DQI; Nonalcoholic fatty liver disease; Uncoupling protein 2 gene ID SERUM TRIGLYCERIDE RESPONSES; CARDIOVASCULAR-DISEASE; MONOUNSATURATED FAT; DIET; POPULATION; PREVALENCE; QUALITY; UCP2; MEN AB The current study evaluated the association between major components of Mediterranean dietary regimen with metabolic biomarkers and uncoupling protein-2 (UCP2) -866G/A gene polymorphism in patients with non-alcoholic limy liver disease (NAFLD). In this study 75 patients with NAFLD and 76 healthy individuals were enrolled. Dietary intakes were assessed using a semi- quantitative food:frequency questionnaire (FFQ) and Mediterranean dietary quality index (Med-DQI) was calculated. Anthropometric assessments were performed; body mass index (BMI) and waist to hip ratio (WHR) were calculated. Biochemical assays including FSG (fasting serum glucose), liver enzymes and lipid profiles were measured. Polymorphism of -866G/A UCP2 gene was determined using polymerase chain reaction-restriction fragment length polymorphism method Serum high density lipoprotein-cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C) concentrations were significantly lower and serum aspartate amino transferase (AST), alanine amino transferase (ALT) and triglyceride (TG) concentrations were significantly higher in NAFLD patients compared with control group (P < 0.05). NAFLD patients with higher intakes of "saturated fatty acids" and "cholesterol" had significantly higher serum TG, while patients with higher intakes of "olive" had lower serum TG and AST concentrations. According to -866A/G of UCP2 gene polymorphism between study groups, only the score of "meat" subgroup in NAFLD patients with GG genotype was higher compared with patients in other genotypes of UCP2 gene (P < 0.05). We observed a significant relationship between Mediterranean dietary quality index and metabolic risk factors. We also demonstrated a higher meat intake in GG genotype among these patients. C1 [Mohseni, Tatemeh; Farhangi, Mahdieh Abbasalizad] Tabriz Univ Med Sci, Sch Nutr, Dept Community Nutr, Nutr Res Ctr, Tabriz, Iran. [Farajnia, Safar; Khoshbaten, Manouchehr] Tabriz Univ Med Sci, Drug Appl Res Ctr, Tabriz, Iran. [Ajourlou, Elham] Tabriz Univ Med Sci, Biotechnol Res Ctr, Tabriz, Iran. [Kakaei, Farzad] Tabriz Univ Med Sci, Imam Reza Hosp, Tabriz, Iran. C3 Tabriz University of Medical Science; Tabriz University of Medical Science; Tabriz University of Medical Science; Tabriz University of Medical Science RP Farhangi, MA (通讯作者)，Tabriz Univ Med Sci, Sch Nutr, Dept Community Nutr, Nutr Res Ctr, Tabriz, Iran. EM abbasalizad_m@yahoo.com RI Khoshbaten, Manouchehr/AAH-2625-2021; Kakaei, Farzad/H-3647-2018; Farhangi, Mahdieh/AAC-6758-2019 OI Khoshbaten, Manouchehr/0000-0001-7054-5274; Kakaei, Farzad/0000-0003-1632-7393; FU Tabriz University of Medical Science [11013] FX We thank all of the participants in the current study. This research was supported by a grant from research undersecretary of Tabriz University of Medical Science (Grant Number: 11013). 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Top. Nutraceutical Res. PD FEB PY 2016 VL 14 IS 1 BP 49 EP 58 PG 10 WC Nutrition & Dietetics; Pharmacology & Pharmacy WE Science Citation Index Expanded (SCI-EXPANDED) SC Nutrition & Dietetics; Pharmacology & Pharmacy GA DN4QR UT WOS:000377052800005 DA 2026-02-02 ER PT J AU Paris, T George, ES Roberts, SK Tierney, AC AF Paris, Tonya George, Elena S. Roberts, Stuart K. Tierney, Audrey C. TI The effects of diet and lifestyle interventions on insulin resistance in patients with nonalcoholic fatty liver disease: a systematic review SO EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY LA English DT Review DE diet; insulin resistance; lifestyle; nonalcoholic fatty liver disease; systematic review ID HEPATIC STEATOSIS; MEDITERRANEAN DIET; METABOLIC SYNDROME; HYPOCALORIC DIETS; OBESE WOMEN; STEATOHEPATITIS; PREVALENCE; OLIVE; OIL; INDIVIDUALS AB Nonalcoholic fatty liver disease (NAFLD) results from excessive fat accumulation in the liver in the absence of excessive alcohol consumption. Insulin resistance (IR) is proposed to be an underlying pathogenic factor in the development and progression of disease. There are currently no proven pharmacotherapies and weight loss is the only prescribed treatment despite a lack of evidence to support a specific diet or lifestyle therapy. The aim of this review is to evaluate the efficacy of dietary lifestyle interventions on IR measured by Homeostasis model assessment in patients with NAFLD. A systematic electronic search of Medline, Scopus, The Cochrane Library, CINAHL and PubMed databases (1999-2015) was performed by two independent reviewers. Randomized control trials evaluating the efficacy of diet and lifestyle interventions on IR in adults diagnosed with NAFLD were included. A total of 6441 articles were identified; eight randomized control trials fulfilled the inclusion criteria. Three studies involved dietary interventions and five incorporated diet and exercise. The majority of intervention groups resulted in significant reductions in IR, with no significant changes observed in the control groups. Lifestyle interventions compared with controls reduced IR measured by homeostasis model assessment. All diet and diet and lifestyle intervention trials were efficient in reducing IR in participants with NAFLD. A lack of literature and variation across interventions warrants the need for extensive research to establish firm dietary lifestyle recommendations. Copyright (C) 2017 Wolters Kluwer Health, Inc. All rights reserved. C1 [Paris, Tonya; George, Elena S.; Tierney, Audrey C.] La Trobe Univ, Dept Rehabil Nutr & Sports, Melbourne, Vic, Australia. [George, Elena S.; Tierney, Audrey C.] Alfred Hosp, Dept Nutr & Dietet, Melbourne, Vic, Australia. [Roberts, Stuart K.] Alfred Hosp, Dept Gastroenterol, Melbourne, Vic, Australia. 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J. Gastroenterol. Hepatol. PD AUG PY 2017 VL 29 IS 8 BP 867 EP 878 DI 10.1097/MEG.0000000000000890 PG 12 WC Gastroenterology & Hepatology WE Science Citation Index Expanded (SCI-EXPANDED) SC Gastroenterology & Hepatology GA FA0AH UT WOS:000405092100001 PM 28471823 DA 2026-02-02 ER PT J AU Bullón-Vela, V Abete, I Tur, JA Pintó, X Corbella, E Martínez-González, MA Toledo, E Corella, D Macías, M Tinahones, F Fitó, M Estruch, R Ros, E Salas-Salvadó, J Daimiel, L Zulet, MA Martínez, JA AF Bullon-Vela, Vanessa Abete, Itziar Tur, Josep A. Pinto, Xavier Corbella, Emili Martinez-Gonzalez, Miguel A. Toledo, Estefania Corella, Dolores Macias, Manuel Tinahones, Francisco Fito, Montserrat Estruch, Ramon Ros, Emilio Salas-Salvado, Jordi Daimiel, Lidia Angeles Zulet, M. Alfredo Martinez, J. CA PREDIMED PLUS Investigators TI Influence of lifestyle factors and staple foods from the Mediterranean diet on non-alcoholic fatty liver disease among older individuals with metabolic syndrome features SO NUTRITION LA English DT Article DE NAFLD; Inflammation; Nutrition; Obesity ID PHYSICAL-ACTIVITY; GLUCOSE INDEX; HEALTH; TRIGLYCERIDE; STEATOSIS; ADHERENCE; SURVIVAL; OBESITY AB Objective: Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver morbidity. This condition often is accompanied by obesity, diabetes, and metabolic syndrome (MetS). The aim of this study was to evaluate the connection between lifestyle factors and NAFLD in individuals with MetS. Methods: A cross-sectional study with 328 participants (55-75 y of age) diagnosed with MetS participating in the PREDIMED-Plus trial was conducted. NAFLD status was evaluated using the non-invasive hepatic steatosis index (HSI). Sociodemographic, clinical, and dietary data were collected. Adherence to the Mediterranean diet (mainly assessed by the consumption of olive oil, nuts, legumes, whole grain foods, fish, vegetables, fruits, and red wine) and physical activity were assessed using validated questionnaires. Results: Linear regression analyses revealed that HSI values tended to be lower with increasing physical activity tertiles (T2, beta = -1.47; 95% confidence interval [CI], -2.73 to -0.20; T3, beta = -1.93; 95% CI, -3.22 to -0.65 versus T1, P-trend = 0.001) and adherence to the Mediterranean diet was inversely associated with HSI values: (moderate adherence beta = -0.70; 95% CI, -1.92 to 0.53; high adherence beta = -1.57; 95% CI, -3.01 to -0.13 versus lower, P-trend = 0.041). Higher tertiles of legume consumption were inversely associated with the highest tertile of HSI (T2, relative risk ratio [RRR], 0.45; 95% CI, 0.22-0.92; P = 0.028; T3, RRR, 0.48; 95% CI, 0.24-0.97; P = 0.041 versus T1). Conclusion: Physical activity, adherence to the Mediterranean diet, and consumption of legumes were inversely associated with a non-invasive marker of NAFLD in individuals with MetS. This data can be useful in implementing precision strategies aimed at the prevention, monitoring, and management of NAFLD. (C) 2019 Elsevier Inc. All rights reserved. C1 [Bullon-Vela, Vanessa; Abete, Itziar; Angeles Zulet, M.; Alfredo Martinez, J.] Univ Navarra, Ctr Nutr Res, Dept Nutr Food Sci & Physiol, Pamplona, Spain. [Abete, Itziar; Tur, Josep A.; Pinto, Xavier; Corbella, Emili; Martinez-Gonzalez, Miguel A.; Toledo, Estefania; Corella, Dolores; Macias, Manuel; Tinahones, Francisco; Fito, Montserrat; Estruch, Ramon; Ros, Emilio; Salas-Salvado, Jordi; Angeles Zulet, M.; Alfredo Martinez, J.] Inst Hlth Carlos III, CIBER Fisiopatol Obesidad & Nutr CIBERobn, Madrid, Spain. [Tur, Josep A.] Univ Balearic Isl, Res Grp Community Nutr & Oxidat Stress, Palma De Mallorca, Spain. [Pinto, Xavier; Corbella, Emili] Hosp Univ Bellvitge, Internal Med, Lipids & Vasc Risk Unit, Barcelona, Spain. [Martinez-Gonzalez, Miguel A.; Toledo, Estefania] Univ Navarra, Dept Prevent Med & Publ Hlth, Pamplona, Spain. [Corella, Dolores] Univ Valencia, Dept Prevent Med, Valencia, Spain. [Macias, Manuel; Tinahones, Francisco] Univ Malaga, Virgen de la Victoria Hosp, Dept Endocrinol, Malaga, Spain. [Fito, Montserrat] Hosp del Mar Res Inst IMIM, Cardiovasc Risk & Nutr Res Grp CARIN, Barcelona, Spain. [Estruch, Ramon] Univ Barcelona, Hosp Clin, Dept Internal Med, IDIBAPS, Barcelona, Spain. [Ros, Emilio] Hosp Clin Barcelona, Inst Invest Biomed August Pi Sunyer IDIBAPS, Dept Endocrinol & Nutr, Lipid Clin, Barcelona, Spain. [Salas-Salvado, Jordi] Rovira & Virgili Univ, Univ Hosp St Joan de Reus, Pere Virgili Inst Hlth Res, Dept Biochem & Biotechnol,Human Nutr Unit, Reus, Spain. [Daimiel, Lidia] UAM, IMDEA Food, Nutr Genom & Epigen Program, CEI,CSIC, Madrid, Spain. C3 University of Navarra; CIBER - Centro de Investigacion Biomedica en Red; CIBEROBN; Universitat de les Illes Balears; University of Barcelona; Institut d'Investigacio Biomedica de Bellvitge (IDIBELL); Bellvitge University Hospital; University of Navarra; University of Valencia; Universidad de Malaga; Hospital del Mar Research Institute; Hospital del Mar; University of Barcelona; Hospital Clinic de Barcelona; IDIBAPS; University of Barcelona; Hospital Clinic de Barcelona; IDIBAPS; Universitat Rovira i Virgili; Institut d'Investigacio Sanitaria Pere Virgili (IISPV); IMDEA Food Institute; Consejo Superior de Investigaciones Cientificas (CSIC); Autonomous University of Madrid RP Zulet, MA (通讯作者)，Univ Navarra, Ctr Nutr Res, Dept Nutr Food Sci & Physiol, Pamplona, Spain.; Zulet, MA (通讯作者)，Inst Hlth Carlos III, CIBER Fisiopatol Obesidad & Nutr CIBERobn, Madrid, Spain. EM mazulet@unav.es RI Daimiel-Ruiz, Lidia Ángeles/M-7779-2014; Fito, Montserrat/C-1822-2012; Zulet, M./H-1317-2017; Martinez-Gonzalez, Miguel/AAE-7669-2019; Corella, Dolores/L-9888-2014; Tinahones, Francisco J/AAB-2882-2020; Bullón-Vela, Vanessa/AFR-2561-2022; Estruch, Ramon/AAZ-3723-2020; Toledo, Estefania/H-6211-2014; Martínez, J./K-8709-2014; Pintó Sala, Xavier/AGI-4297-2022; Corbella, Emili/AGI-4105-2022; Salas-Salvadó, Jordi/C-7229-2017; Tur, Josep/AAE-5748-2020 OI Daimiel-Ruiz, Lidia Ángeles/0000-0001-9898-6629; Tinahones, Francisco J/0000-0001-6871-4403; Bullón-Vela, Vanessa/0000-0003-3639-821X; Pintó Sala, Xavier/0000-0002-2216-2444; Corbella, Emili/0000-0001-8818-1907; Salas-Salvadó, Jordi/0000-0003-2700-7459; Tur, Josep/0000-0002-6940-0761 FU Institute de Salud Carlos Ill (ISCIII), through the Fondo de Investigacidn para la Salud (FIS) [PI14/01919, PI17/00926]; European Regional Development Fund (ERDF); CIBER Fisiopatologia de la Obesidad y Nutrition (CIBERobn); European Research Council [340918]; Center for Nutrition Research of the University of Navarra; European Research Council (ERC) [340918] Funding Source: European Research Council (ERC) FX This work was supported by the Institute de Salud Carlos Ill (ISCIII), through the Fondo de Investigacidn para la Salud (FIS, PI14/01919 and PI17/00926), co-funded by the European Regional Development Fund (ERDF), CIBER Fisiopatologia de la Obesidad y Nutrition (CIBERobn) and by European Research Council (Advanced Research Grant 2014-2019; agreement #340918 granted to MAM-G). VBV received a grant from the Center for Nutrition Research of the University of Navarra. VBV and IA contributed equally to this study. VBV, IA, MAZ, and JAM were involved in conceptualization, design, acquisition of data, analysis, and interpretation of data; writing of the original draft preparation; and critical revision of the manuscript for important intellectual content. JAT, XP, EC, MAM-G, ET, DC, MM, FT, MF, RE, ER, JS-S, and LD were involved in study design, acquisition of data, and interpretation data; and critical revision of the manuscript for important intellectual content. All authors approved the final version of the manuscript. The authors have no conflicts of interest to declare. 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M. Erler, Nicole S. de Knegt, Robert J. Janssen, Harry L. A. Metselaar, Herold J. Murad, Sarwa Darwish Kiefte-de Jong, Jessica C. TI Adherence to a plant-based, high-fibre dietary pattern is related to regression of non-alcoholic fatty liver disease in an elderly population SO EUROPEAN JOURNAL OF EPIDEMIOLOGY LA English DT Article DE Hepatic steatosis; Dietary patterns; Mediterranean; Plant-based ID HEPATIC STEATOSIS; MEDITERRANEAN DIET; MULTIPLE IMPUTATION; GENERAL-POPULATION; METABOLIC SYNDROME; WEIGHT-LOSS; STIFFNESS; REPRODUCIBILITY; QUESTIONNAIRE; CONSUMPTION AB Dietary lifestyle intervention is key in treating non-alcoholic fatty liver disease (NAFLD). We aimed to examine the longitudinal relation between well-established dietary patterns as well as population-specific dietary patterns and NAFLD. Participants from two subsequent visits of the Rotterdam Study were included. All underwent serial abdominal ultrasonography (median follow-up: 4.4 years) and filled in a food frequency questionnaire. Secondary causes of steatosis were excluded. Dietary data from 389 items were collapsed into 28 food groups and a posteriori dietary patterns were identified using factor analysis. Additionally, we scored three a priori dietary patterns (Mediterranean Diet Score, Dutch Dietary Guidelines and WHO-score). Logistic mixed regression models were used to examine the relation between dietary patterns and NAFLD. Analyses were adjusted for demographic, lifestyle and metabolic factors. We included 963 participants of whom 343 had NAFLD. Follow-up data was available in 737 participants. Incident NAFLD was 5% and regressed NAFLD was 30%. We identified five a posteriori dietary patterns (cumulative explained variation [R-2] = 20%). The patterns were characterised as: vegetable and fish, red meat and alcohol, traditional, salty snacks and sauces, high fat dairy & refined grains pattern. Adherence to the traditional pattern (i.e. high intake of vegetable oils/stanols, margarines/butters, potatoes, whole grains and sweets/desserts) was associated with regression of NAFLD per SD increase in Z-score (0.40, 95% CI 0.15-1.00). Adherence to the three a priori patterns all showed regression of NAFLD, but only the WHO-score showed a distinct association (0.73, 95% CI 0.53-1.00). Hence, in this large elderly population, adherence to a plant-based, high-fibre and low-fat diet was related to regression of NAFLD. C1 [Alferink, Louise J. M.; de Knegt, Robert J.; Metselaar, Herold J.; Murad, Sarwa Darwish] Univ Med Ctr Rotterdam, Dept Gastroenterol & Hepatol, Erasmus MC, Rotterdam, Netherlands. [Erler, Nicole S.] Univ Med Ctr Rotterdam, Dept Biostat, Erasmus MC, Rotterdam, Netherlands. [Janssen, Harry L. A.] Univ Hlth Network, Toronto Gen Hosp, Toronto Ctr Liver Dis, Toronto, ON, Canada. [Kiefte-de Jong, Jessica C.] Univ Med Ctr Rotterdam, Dept Epidemiol, Erasmus MC, Rotterdam, Netherlands. [Kiefte-de Jong, Jessica C.] Leiden Univ, Dept Publ Hlth & Primary Care, Med Ctr, LUMC Campus Hague,Postzone VO P,Postbus 9600, NL-2300 RC Leiden, Netherlands. C3 Erasmus University Rotterdam; Erasmus MC; Erasmus University Rotterdam; Erasmus MC; University of Toronto; University Health Network Toronto; Toronto General Hospital; Erasmus University Rotterdam; Erasmus MC; Leiden University; Leiden University Medical Center (LUMC); Leiden University - Excl LUMC RP Kiefte-de Jong, JC (通讯作者)，Univ Med Ctr Rotterdam, Dept Epidemiol, Erasmus MC, Rotterdam, Netherlands.; Kiefte-de Jong, JC (通讯作者)，Leiden Univ, Dept Publ Hlth & Primary Care, Med Ctr, LUMC Campus Hague,Postzone VO P,Postbus 9600, NL-2300 RC Leiden, Netherlands. EM j.c.kiefte@lumc.nl RI De Knegt, Robert/X-4629-2019; Kiefte-de Jong, Jessica/GLV-3216-2022; Darwish Murad, Sarwa/AAO-5493-2020 OI Darwish Murad, Sarwa/0000-0003-2804-1165; Erler, Nicole/0000-0002-9370-6832; Janssen, Harry/0000-0003-2398-8392 FU Erasmus MC University Medical Centre and Erasmus University Rotterdam; Netherlands Organization for Scientific Research (NWO); Netherlands Organization for Health Research and Development (ZonMw); Research Institute for Diseases in the Elderly (RIDE); Ministry of Education, Culture and Science; Ministry of Health, Welfare and Sports; European Commission (DG XII); Municipality of Rotterdam; Den Dulk-Moermans foundation (Leiden University Fund) FX The Rotterdam Study is supported by the Erasmus MC University Medical Centre and Erasmus University Rotterdam, the Netherlands Organization for Scientific Research (NWO), the Netherlands Organization for Health Research and Development (ZonMw), the Research Institute for Diseases in the Elderly (RIDE), the Ministry of Education, Culture and Science, the Ministry of Health, Welfare and Sports, the European Commission (DG XII) and by the Municipality of Rotterdam. JCK received a grant from the Den Dulk-Moermans foundation (Leiden University Fund). 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J. Epidemiol. PD NOV PY 2020 VL 35 IS 11 BP 1069 EP 1085 DI 10.1007/s10654-020-00627-2 EA APR 2020 PG 17 WC Public, Environmental & Occupational Health WE Science Citation Index Expanded (SCI-EXPANDED) SC Public, Environmental & Occupational Health GA PE1XJ UT WOS:000528157800001 PM 32323115 OA Green Submitted, hybrid DA 2026-02-02 ER PT J AU Das, A Tang, YLM Althumiri, NA Garcia-Larsen, V Schattenberg, JM Alqahtani, SA AF Das, Arpita Tang, Yu Lung Malcolm Althumiri, Nora A. Garcia-Larsen, Vanessa Schattenberg, Joern M. Alqahtani, Saleh A. TI Fatty acid composition but not quantity is an important indicator of non-alcoholic fatty liver disease: a systematic review SO EUROPEAN JOURNAL OF CLINICAL NUTRITION LA English DT Review ID HEPATIC STEATOSIS; DIETARY INTERVENTION; MEDITERRANEAN DIET; ASIAN INDIANS; DOUBLE-BLIND; LIFE-STYLE; OLIVE OIL; STEATOHEPATITIS; EFFICACY; ADULTS AB BackgroundThere is still paucity on the effects of dietary and supplemental fatty acid on non-alcoholic fatty liver disease (NAFLD). The aim of this review is to systematically review and summarise the effect of fatty acids intake on liver-related outcomes in adult patients with NAFLD.MethodsThe review was conducted using Cochrane CENTRAL Library, Scopus, Embase, MEDLINE, PubMed, and Web of Science. A total of 2786 records were identified, and of these, 36 studies (31 were randomised control trials (RCTs), and 5 were case-control studies) were included. Quality assessment was conducted using the Revised Cochrane Risk of Bias tool and Joanna Briggs Institute checklists.ResultsOf 36 articles, 79% of RCTs and 66% of case-control studies had a low risk of bias. Potential heterogeneity has been observed in assessment of liver-related outcomes. According to the RCTs, there was moderate evidence (3/6 studies) that a diet characterised by a high MUFA, PUFA and low SFA showed reduced liver fat and stiffness. The using of culinary fats that are high in MUFA (4/6 studies) reduces liver steatosis. n-3 PUFA supplementation in combination with a hypocaloric or heart healthy diet with a low SFA improved liver enzyme level (5/14 studies) and steatosis score (3/14 studies).ConclusionsEffects on NAFLD parameters, including liver fat content (assessed via magnetic resonance imaging/spectroscopy), stiffness and steatosis score (assessed by ultrasonography), were primarily related to fatty acid composition independent of energy intake. Further investigation is needed to determine the mechanism of specific fatty acid on the accumulation of liver fat. C1 [Das, Arpita; Tang, Yu Lung Malcolm] Univ Sydney, Charles Perkins Ctr, Dept Nutr & Dietet, Sydney, NSW, Australia. [Althumiri, Nora A.] Sharik Assoc Hlth Res, Riyadh, Saudi Arabia. [Garcia-Larsen, Vanessa] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Int Hlth, Program Human Nutr, Baltimore, MD USA. [Schattenberg, Joern M.] Univ Med Ctr, Dept Med 1, Metab Liver Res Program, Mainz, Germany. [Alqahtani, Saleh A.] Johns Hopkins Univ, Div Gastroenterol & Hepatol, Baltimore, MD 21218 USA. [Alqahtani, Saleh A.] King Faisal Specialist Hosp & Res Ctr, Liver Transplantat Ctr, Riyadh, Saudi Arabia. C3 University of Sydney; Johns Hopkins University; Johns Hopkins Bloomberg School of Public Health; Johannes Gutenberg University of Mainz; Johns Hopkins University; King Faisal Specialist Hospital & Research Center RP Das, A (通讯作者)，Univ Sydney, Charles Perkins Ctr, Dept Nutr & Dietet, Sydney, NSW, Australia. EM arpita.das@sydney.edu.au RI Althumiri, Nora/HGC-1768-2022; Alqahtani, Saleh/ADB-1075-2022; Schattenberg, Jörn/C-1301-2013 OI Garcia Larsen, Vanessa/0000-0002-0003-1988 FU King Faisal Specialist Hospital amp; Research Centre FX The study was funded by the King Faisal Specialist Hospital & Research Centre. 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J. Clin. Nutr. PD DEC PY 2023 VL 77 IS 12 BP 1113 EP 1129 DI 10.1038/s41430-023-01335-2 EA SEP 2023 PG 17 WC Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Nutrition & Dietetics GA LI5R5 UT WOS:001057856700001 PM 37661229 DA 2026-02-02 ER PT J AU Reddy, A Della Gatta, P Mason, S Nicoll, AJ Ryan, M Itsiopoulos, C Abbott, G Johnson, NA Sood, S Roberts, SK George, ES Tierney, AC AF Reddy, Anjana Della Gatta, Paul Mason, Shaun Nicoll, Amanda J. Ryan, Marno Itsiopoulos, Catherine Abbott, Gauin Johnson, Nathan A. Sood, Siddharth Roberts, Stuart K. George, Elena S. Tierney, Audrey C. TI Adherence to a Mediterranean diet may improve serum adiponectin in adults with nonalcoholic fatty liver disease: The MEDINA randomized controlled trial SO NUTRITION RESEARCH LA English DT Article DE Nonalcoholic fatty liver disease; Diet intervention; Mediterranean diet; Inflammation; Adiponectin ID INSULIN SENSITIVITY; INFLAMMATION; ACID; STEATOHEPATITIS; EPIDEMIOLOGY; INDIVIDUALS; PREVALENCE; RESISTANCE; PATTERNS; MARKERS AB Nonalcoholic fatty liver disease (NAFLD) affects approximately 30% of adults worldwide, with chronic low-grade inflammation being a key pathophysiological feature of progression. The Mediterranean diet (MedDiet) is recognized for improving metabolic and hepatic outcomes in people with diabetes and NAFLD, in part, via anti-inflammatory properties. The aim of this study was to determine the effect of an ad libitum MedDiet versus low-fat diet (LFD) on inflammatory markers in adults with NAFLD. It was hypothesized that the MedDiet, and its individual components, would improve inflammation. This multicenter, randomized controlled trial, randomized participants to a MedDiet or LFD intervention for 12 weeks. Primary outcomes included change from baseline to 12 weeks for serum highsensitivity C-reactive protein, interleukin-6, tumor necrosis factor-alpha, adiponectin, leptin, and resistin. Forty-two participants (60% female; age 52.3 +/- 12.6 years; body mass index, 32.2 +/- 6.2 kg/m(2)) were randomized to the MedDiet (n = 19) or low-fat diet (n = 23). At 12 weeks, the LFD showed a greater decrease in leptin compared with the MedDiet (-1.20 +/- 3.9 ng/mL vs 0.64 +/- 3.5 ng/mL, P = .010). Adiponectin significantly improved within the MedDiet (13.7 +/- 9.2 mu g/mL to 17.0 +/- 12.5 mu g/mL, P = .016), but not within the LFD group. No statistically significant changes were observed for other inflammatory markers following the MedDiet or LFD. Adherence to the MedDiet significantly improved in both study arms, although greater improvements were seen in the MedDiet group. Adiponectin significantly improved following a Mediterranean diet intervention, in the absence of weight loss. The low-fat diet did not elicit improvements in inflammatory markers. High-quality clinical trials appropriately powered to inflammatory markers are required in this population. (c) 2023 The Authors. Published by Elsevier Inc. C1 [Reddy, Anjana; Itsiopoulos, Catherine; George, Elena S.; Tierney, Audrey C.] La Trobe Univ, Sch Allied Hlth Human Serv & Sport, Melbourne, Australia. [Reddy, Anjana; Abbott, Gauin] Monash Univ, Sch Publ Hlth & Preventat Med, Monash Ctr Hlth Res & Implementat, Melbourne, Vic, Australia. [Della Gatta, Paul; Mason, Shaun; George, Elena S.] Deakin Univ, Inst Phys Act & Nutr, Sch Exercise & Nutr Sci, Geelong, Australia. [Nicoll, Amanda J.] Eastern Hlth, Dept Gastroenterol, Box Hill, Australia. [Ryan, Marno] St Vincents Hosp, Dept Gastroenterol & Hepatol, Fitzroy, Australia. [Itsiopoulos, Catherine] RMIT Univ, Sch Hlth & Biomed Sci, Melbourne, Australia. [Johnson, Nathan A.] Univ Sydney, Boden Collaborat Obes Exercise & Eating Disorders, Sydney, NSW, Australia. [Sood, Siddharth] Melbourne Hlth, Dept Gastroenterol, Melbourne, Australia. [Sood, Siddharth] Univ Melbourne, Dept Med, Parkville, Australia. [Roberts, Stuart K.] Alfred Hlth, Dept Gastroenterol, Prahran, Australia. [Roberts, Stuart K.] Monash Univ, Cent Clin Sch, Clayton, Australia. [Tierney, Audrey C.] Univ Limerick, Hlth Res Inst, Sch Allied Hlth Hlth Implementat Sci & Technol Res, Limerick, Ireland. [George, Elena S.] Deakin Univ, Inst Phys Act & Nutr IPAN, Sch Exercise & Nutr Sci, Geelong 3220, Australia. C3 La Trobe University; Monash University; Deakin University; Eastern Health; NSW Health; St Vincents Hospital Sydney; St Vincent's Health; St Vincent's Hospital Melbourne; Royal Melbourne Institute of Technology (RMIT); University of Sydney; University of Melbourne; Alfred Health; Monash University; University of Limerick; Deakin University RP George, ES (通讯作者)，Deakin Univ, Inst Phys Act & Nutr IPAN, Sch Exercise & Nutr Sci, Geelong 3220, Australia. EM elena.george@deakin.edu.au RI Johnson, Nathan/Q-3158-2016; George, Elena/J-3357-2019; Tierney, Audrey/AAB-7068-2022 OI Johnson, Nathan/0000-0002-3874-7092; Roberts, Stuart/0000-0002-9015-7997; Reddy, Anj/0009-0007-3332-8597; Mason, Shaun/0000-0002-6138-2239; FU La Trobe University Research Focus Area 'Understanding Disease' grant; Australasian Society of Parenteral and Enteral Nutrition small project grant; Australian Government Research Training Program Scholarship FX This project was funded by a La Trobe University Research Focus Area 'Understanding Disease' grant. The analysis of inflammatory cytokine and adipokine markers was funded by an Australasian Society of Parenteral and Enteral Nutrition small project grant. This work was supported by an Australian Government Research Training Program Scholarship (A.R., E.S.G.). Food was donated for study participant hampers from Boundary Bend, Almond Board of Australia, Jalna, HJ Heinz, Simplot, and Carmen's; these companies had no input into the trial design or delivery. 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PD NOV PY 2023 VL 119 BP 98 EP 108 DI 10.1016/j.nutres.2023.09.005 EA OCT 2023 PG 11 WC Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Nutrition & Dietetics GA W0LT7 UT WOS:001088638700001 PM 37801761 OA Green Submitted, hybrid DA 2026-02-02 ER PT J AU Cinque, F Cespiati, A Lombardi, R Costantino, A Maffi, G Alletto, F Colavolpe, L Francione, P Oberti, G Fatta, E Bertelli, C Sigon, G Dongiovanni, P Vecchi, M Fargion, S Fracanzani, AL AF Cinque, Felice Cespiati, Annalisa Lombardi, Rosa Costantino, Andrea Maffi, Gabriele Alletto, Francesca Colavolpe, Lucia Francione, Paolo Oberti, Giovanna Fatta, Erika Bertelli, Cristina Sigon, Giordano Dongiovanni, Paola Vecchi, Maurizio Fargion, Silvia Fracanzani, Anna Ludovica TI Interaction between Lifestyle Changes and PNPLA3 Genotype in NAFLD Patients during the COVID-19 Lockdown SO NUTRIENTS LA English DT Article DE NAFLD; Mediterranean diet; physical activity; PNPLA3; weight gain; lockdown; SARS-CoV-2 ID FATTY LIVER-DISEASE; PHYSICAL-ACTIVITY; WEIGHT-LOSS; I148M POLYMORPHISM; HEPATIC STEATOSIS; CLINICAL-PRACTICE; GENETIC-VARIATION; EXERCISE; DIET; ASSOCIATION AB The coronavirus disease 2019 (COVID-19) lockdown dramatically changed people's lifestyles. Diet, physical activity, and the PNPLA3 gene are known risk factors for non-alcoholic fatty liver disease (NAFLD). Aim: To evaluate changes in metabolic and hepatic disease in NAFLD patients after the COVID-19 lockdown. Three hundred and fifty seven NAFLD patients were enrolled, all previously instructed to follow a Mediterranean diet (MD). Anthropometric, metabolic, and laboratory data were collected before the COVID-19 lockdown in Italy and 6 months apart, along with ultrasound (US) steatosis grading and information about adherence to MD and physical activity (PA). In 188 patients, PNPLA3 genotyping was performed. After the lockdown, 48% of patients gained weight, while 16% had a worsened steatosis grade. Weight gain was associated with poor adherence to MD (p = 0.005), reduced PA (p = 0.03), and increased prevalence of PNPLA3 GG (p = 0.04). At multivariate analysis (corrected for age, sex, MD, PA, and PNPLA3 GG), only PNPLA3 remained independently associated with weight gain (p = 0.04), which was also associated with worsened glycemia (p = 0.002) and transaminases (p = 0.02). During lockdown, due to a dramatic change in lifestyles, half of our cohort of NAFLD patients gained weight, with a worsening of metabolic and hepatologic features. Interestingly, the PNPLA3 GG genotype nullified the effect of lifestyle and emerged as an independent risk factor for weight gain, opening new perspectives in NAFLD patient care. C1 [Cinque, Felice; Cespiati, Annalisa; Lombardi, Rosa; Maffi, Gabriele; Alletto, Francesca; Colavolpe, Lucia; Francione, Paolo; Oberti, Giovanna; Fatta, Erika; Bertelli, Cristina; Sigon, Giordano; Dongiovanni, Paola; Fargion, Silvia; Fracanzani, Anna Ludovica] Fdn Ca Granda IRCCS Osped Maggiore Policlin, Unit Internal Med & Metab Dis, I-20122 Milan, Italy. [Cinque, Felice; Cespiati, Annalisa; Lombardi, Rosa; Costantino, Andrea; Maffi, Gabriele; Alletto, Francesca; Colavolpe, Lucia; Francione, Paolo; Oberti, Giovanna; Sigon, Giordano; Vecchi, Maurizio; Fargion, Silvia; Fracanzani, Anna Ludovica] Univ Milan, Dept Pathophysiol & Transplantat, I-20122 Milan, Italy. [Costantino, Andrea; Vecchi, Maurizio] Fdn Ca Granda IRCCS Osped Maggiore Policlin, Unit Gastroenterol & Endoscopy, I-20122 Milan, Italy. C3 IRCCS Ca Granda Ospedale Maggiore Policlinico; University of Milan; IRCCS Ca Granda Ospedale Maggiore Policlinico RP Lombardi, R (通讯作者)，Fdn Ca Granda IRCCS Osped Maggiore Policlin, Unit Internal Med & Metab Dis, I-20122 Milan, Italy.; Lombardi, R (通讯作者)，Univ Milan, Dept Pathophysiol & Transplantat, I-20122 Milan, Italy. EM felice.cinque@unimi.it; annalisa.cespiati@unimi.it; rosa.lombardi@unimi.it; andrea.costantino@unimi.it; gabriele.maffi1@unimi.it; francesca.alletto@unimi.it; lucia.colavolpe@unimi.it; paolo.francione@unimi.it; giovanna.oberti@unimi.it; erika.fatta@policlinico.mi.it; cristina.bertelli@policlinico.mi.it; giordano.sigon@unimi.it; paola.dongiovanni@policlinico.mi.it; maurizio.vecchi@unimi.it; silvia.fargion@unimi.it; anna.fracanzani@unimi.it RI Dongiovanni, Paola/AAC-9965-2019; Fracanzani, Anna Ludovica/J-8986-2018; Lombardi, Rosa/AAB-8031-2019; Costantino, Anea/AAC-1655-2019; Sigon, Giordano/KBB-9336-2024; CINQUE, FELICE/LTE-1682-2024; Cespiati, Annalisa/GRJ-1523-2022 OI Dongiovanni, Paola/0000-0003-4343-7213; Fracanzani, Anna Ludovica/0000-0001-5918-0171; Lombardi, Rosa/0000-0001-6958-927X; Costantino, Anea/0000-0003-4345-6051; Sigon, Giordano/0000-0001-9707-5778; CINQUE, FELICE/0000-0003-1499-9233; CR Amer Diabet Assoc, 2014, DIABETES CARE, V37, pS14, DOI 10.2337/dc14-S014 Anstee QM, 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GA YZ1OQ UT WOS:000755252300001 PM 35276911 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Trovato, GM Martines, GF Trovato, FM Pirri, C Pace, P Garozzo, A Castro, A Catalano, D AF Trovato, Guglielmo M. Martines, Giuseppe Fabio Trovato, Francesca M. Pirri, Clara Pace, Patrizia Garozzo, Adriana Castro, Angelo Catalano, Daniela TI Adenovirus-36 Seropositivity Enhances Effects of Nutritional Intervention on Obesity, Bright Liver, and Insulin Resistance SO DIGESTIVE DISEASES AND SCIENCES LA English DT Article DE Fatty liver; Ultrasound; Insulin resistance; Mediterranean diet; BMI; Dietology ID WEIGHT-LOSS; NONALCOHOLIC STEATOHEPATITIS; HEPATIC STEATOSIS; BODY-COMPOSITION; GLUCOSE-UPTAKE; DISEASE; IMPACT; SENSITIVITY; PREVALENCE; EXERCISE AB Obesity and liver steatosis are both currently attributed to inappropriate lifestyle and nutrition. Higher prevalence of human adenovirus Ad36 seropositivity (Ad36+) is reported only in obesity. To investigate whether a lifestyle-nutritional intervention achieves different outcomes in NAFLD patients, i.e., if is blunted or enhanced according to Ad36 seropositivity status. One-year nutritional intervention was planned and accomplished for 62 non-alcoholic fatty liver disease overweight-obese patients, studied by liver ultrasound, evaluating Bright Liver Score (BLS), by Homeostatic Model assessment of Insulin Resistance (HOMA), by body composition and Ad36+ assay. Lower salt/lower calories Mediterranean diet, physical activity increase, smoking withdrawal and lifestyle counseling, provided by a health psychologist, were given. Ad36 seropositive patients have baseline greater BMI with the same level of BLS. Different prevalence of post-interventional response, significantly greater among Ad36+ patients, is observed: greater decrease of obesity, assessed by BMI, greater reduction of insulin resistance, assessed by HOMA and higher prevalence of bright liver disappearance. A BMI-adjusted multiple linear regression model explains significantly 23.8% (p < 0.04) of the variance; significant predictive variables are Ad36 seropositivity (p < 0.012) and fat mass loss (p < 0.011) accounting for the variance of the occurrence of bright liver disappearance. Ad36 previous infection is significantly associated with enhanced weight loss, bright liver disappearance, and recovery of insulin sensitivity through the chosen tailored nutritional interventional treatment. Nonetheless, Ad36 seronegative NAFLD patients' fatty liver pattern improves, at a lower extent, also without significant weight loss: an effect of dietary changes profile, Mediterranean diet, not only of lowered food caloric intake, is conceivably operating. C1 [Trovato, Guglielmo M.; Martines, Giuseppe Fabio; Trovato, Francesca M.; Pirri, Clara; Pace, Patrizia; Catalano, Daniela] Univ Catania, Fac Med & Chirurg, Clin Med Interna & Terapia Med, Dept Internal Med, I-95131 Catania, Italy. [Garozzo, Adriana; Castro, Angelo] Univ Catania, Fac Med & Chirurg, Dept Microbiol & Gynaecol Sci, I-95131 Catania, Italy. C3 University of Catania; University of Catania RP Trovato, GM (通讯作者)，Univ Catania, Fac Med & Chirurg, Clin Med Interna & Terapia Med, Dept Internal Med, Via St Orsola 30, I-95131 Catania, Italy. 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PD FEB PY 2012 VL 57 IS 2 BP 535 EP 544 DI 10.1007/s10620-011-1903-8 PG 10 WC Gastroenterology & Hepatology WE Science Citation Index Expanded (SCI-EXPANDED) SC Gastroenterology & Hepatology GA 881LS UT WOS:000299487500039 PM 21953137 DA 2026-02-02 ER PT J AU Lampignano, L Donghia, R Sila, A Bortone, I Tatoli, R De Nucci, S Castellana, F Zupo, R Tirelli, S Giannoccaro, V Guerra, V Panza, F Lozupone, M Mastronardi, M De Pergola, G Giannelli, G Sardone, R AF Lampignano, Luisa Donghia, Rossella Sila, Annamaria Bortone, Ilaria Tatoli, Rossella De Nucci, Sara Castellana, Fabio Zupo, Roberta Tirelli, Sarah Giannoccaro, Viviana Guerra, Vito Panza, Francesco Lozupone, Madia Mastronardi, Mauro De Pergola, Giovanni Giannelli, Gianluigi Sardone, Rodolfo TI Mediterranean Diet and Fatty Liver Risk in a Population of Overweight Older Italians: A Propensity Score-Matched Case-Cohort Study SO NUTRIENTS LA English DT Article DE NAFLD; Mediterranean diet; older; alcohol; meat; liver; fatty liver index (FLI) ID CARDIOVASCULAR-DISEASE; ALCOHOL-CONSUMPTION; INSULIN CONCENTRATIONS; METABOLIC SYNDROME; HEPATIC STEATOSIS; OBESITY; ADHERENCE; PATTERNS; MEAT; INFLAMMATION AB Hepatic steatosis, often known as fatty liver, is the most common hepatic disease in Western countries. The latest guidelines for the treatment of nonalcoholic fatty liver disease emphasize lifestyle measures, such as changing unhealthy eating patterns. Using a propensity score-matching approach, this study investigated the effect of adhering to a Mediterranean diet (MedDiet) on fatty liver risk in an older population (>= 65 years) from Southern Italy. We recruited 1.403 subjects (53.6% men, >= 65 years) who completed a food frequency questionnaire (FFQ) and underwent clinical assessment between 2015 and 2018. For the assessment of the liver fat content, we applied the Fatty Liver Index (FLI). To evaluate the treatment effect of the MedDiet, propensity score matching was performed on patients with and without FLI > 60. After propensity score-matching with the MedDiet pattern as treatment, we found a higher consumption of red meat (p = 0.04) and wine (p = 0.04) in subjects with FLI > 60. Based on the FLI, the inverse association shown between adherence to the MedDiet and the risk of hepatic steatosis shows that the MedDiet can help to prevent hepatic steatosis. Consuming less red and processed meat, as well as alcoholic beverages, may be part of these healthy lifestyle recommendations. C1 [Lampignano, Luisa; Donghia, Rossella; Sila, Annamaria; Bortone, Ilaria; Tatoli, Rossella; De Nucci, Sara; Castellana, Fabio; Zupo, Roberta; Tirelli, Sarah; Guerra, Vito; Sardone, Rodolfo] Natl Inst Gastroenterol Saverio de Bellis, Res Hosp, Unit Data Sci & Technol Innovat Populat Hlth, I-70013 Bari, Italy. [Giannoccaro, Viviana] Publ Hlth Applicat Ctr, I-70043 Bari, Italy. [Panza, Francesco; Lozupone, Madia] Univ Bari Aldo Moro, Dept Basic Med Neurosci & Sense Organs, Neurodegenerat Dis Unit, I-70125 Bari, Italy. [Mastronardi, Mauro] Saverio De Bellis Res Hosp, Natl Inst Gastroenterol, Inflammatory Bowel Dis Unit, I-70013 Bari, Italy. [De Pergola, Giovanni] Natl Inst Gastroenterol Saverio De Bellis, Res Hosp, Unit Geriatr & Internal Med, I-70013 Bari, Italy. [Giannelli, Gianluigi] Saverio De Bellis Res Hosp, Natl Inst Gastroenterol, Sci Direct, I-70013 Bari, Italy. C3 Universita degli Studi di Bari Aldo Moro RP Sardone, R (通讯作者)，Natl Inst Gastroenterol Saverio de Bellis, Res Hosp, Unit Data Sci & Technol Innovat Populat Hlth, I-70013 Bari, Italy. EM luisa.lampignano@irccsdebellis.it; rossydonghia@gmail.com; annamaria.sila@irccsdebellis.it; ilariabortone@gmail.com; rossella.tatoli@irccsdebellis.it; sara.denucci@irccsdebellis.it; fabio.castellana@irccsdebellis.it; zuporoberta@gmail.com; sarah.tirelli@irccsdebellis.it; vivianagiannoccaro@icloud.com; vito.guerra@irccsdebellis.it; f_panza@hotmail.com; madia.lozupone@gmail.com; mauro.mastronardi@irccsdebellis.it; gdepergola@libero.it; gianluigi.giannelli@irccsdebellis.it; rodolfo.sardone@irccsdebellis.it RI ; Sardone, Rodolfo/AAM-2727-2020; Zupo, Roberta/GPT-3724-2022; lozupone, madia/F-7262-2018; Giannoccaro, Viviana/IQS-3554-2023; giannelli, gianluigi/A-8169-2012; Panza, Francesco/M-6804-2017; Lampignano, Luisa/AAA-3108-2022; Castellana, Fabio/IZD-7987-2023; Bortone, Ilaria/HPE-3696-2023 OI Tirelli, Sarah/0000-0002-5521-2508; Sardone, Rodolfo/0000-0003-1383-1850; Zupo, Roberta/0000-0001-9885-1185; lozupone, madia/0000-0002-1674-9724; Giannoccaro, Viviana/0000-0002-4183-0487; Donghia, Rossella/0000-0002-9140-673X; Panza, Francesco/0000-0002-7220-0656; Lampignano, Luisa/0000-0001-9299-3211; Tatoli, Rossella/0000-0002-7891-6057; Castellana, Fabio/0000-0002-6439-8228; Bortone, Ilaria/0000-0002-4767-5334 FU Italian Ministry of Health; Apulia Government; Italian Ministry of Health, under the Studies on Aging Network, at Italian Research Hospitals (IRCCS) FX This study was funded by the Italian Ministry of Health with the "Ricerca Corrente 2019" Grant and by the Apulia Government with the "Regione Puglia Grant 2018". The Salus in Apulia Study was funded by Apulia Government and Italian Ministry of Health, under the Studies on Aging Network, at Italian Research Hospitals (IRCCS). 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SWITZERLAND EI 2072-6643 J9 NUTRIENTS JI Nutrients PD JAN PY 2022 VL 14 IS 2 AR 258 DI 10.3390/nu14020258 PG 15 WC Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Nutrition & Dietetics GA ZG7KA UT WOS:000760433000001 PM 35057439 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Rosqvist, F Rydell, A Iggenan, D AF Rosqvist, Fredrik Rydell, Andreas Iggenan, David TI The Effects of Foods on Blood Lipids in Non-alcoholic Fatty Liver Disease (NAFLD)-A Systematic Review and Meta-Analysis SO FRONTIERS IN NUTRITION LA English DT Review DE NAFLD; steatosis; cholesterol; triglycerides; diet; food ID INSULIN-SENSITIVITY; MEDITERRANEAN DIET; HEPATIC STEATOSIS; RANDOMIZED-TRIAL; DOUBLE-BLIND; MUFA DIET; INTERVENTION; DYSLIPIDEMIA; INDIVIDUALS; CONSUMPTION AB Background: Non-alcoholic fatty liver disease (NAFLD) is associated with dyslipidemia and increased cardiovascular disease risk. Dietary choices may produce profound effects on blood lipids. Thus, the purpose of this study was to investigate which foods modify blood lipids in NAFLD. Methods: Systematic review of published systematic reviews and randomized controlled trials (RCTs). Searches were performed in PubMed, Cochrane Database of Systematic Reviews, and Cochrane Central Register of Controlled Trials, from inception through March 2020. Studies in populations with NAFLD, which provided data on foods or dietary patterns and blood lipids were included, but not weight loss diets, supplements, nor individual nutrients. The strength of evidence was evaluated using The Grading of Recommendations Assessment, Development, and Evaluation (GRADE). Results: No relevant systematic reviews were identified. Eleven RCTs were included in the qualitative synthesis. Two RCTs were included in meta-analyses, regarding the comparison between Mediterranean and Low-fat diets, in which there were no clear effects on either high-density lipoprotein cholesterol or triglycerides, with Low evidence. From single RCTs, there was Moderate evidence for reduced triglycerides by a healthy dietary pattern, compared with usual care; and for reduced total cholesterol by a probiotic yogurt, enriched with Lactobacillus acidophilus La5 and Bifidobacterium lactis Bb12, compared with conventional yogurt. For all other comparisons, the evidence was considered as Low or Very low. Conclusion: Few studies were identified which reported effects of foods on blood lipids in subjects with NAFLD. The possible beneficial effect of probiotics warrants further study. PROSPERO identifier: CRD42020178927. C1 [Rosqvist, Fredrik; Iggenan, David] Uppsala Univ, Dept Publ Hlth & Caring Sci, Clin Nutr & Metab, Uppsala, Sweden. [Rydell, Andreas; Iggenan, David] Ctr Clin Res Dalarna, Norslund Svardsjo Acad Hlth Care Ctr, Falun, Sweden. [Rydell, Andreas] Karolinska Inst, Dept Neurobiol Care Sci & Soc NVS, Div Family Med & Primary Care, Huddinge, Sweden. C3 Uppsala University; Karolinska Institutet RP Iggenan, D (通讯作者)，Uppsala Univ, Dept Publ Hlth & Caring Sci, Clin Nutr & Metab, Uppsala, Sweden.; Iggenan, D (通讯作者)，Ctr Clin Res Dalarna, Norslund Svardsjo Acad Hlth Care Ctr, Falun, Sweden. 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Nutr. PD DEC 16 PY 2020 VL 7 AR 613221 DI 10.3389/fnut.2020.613221 PG 11 WC Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Nutrition & Dietetics GA PL8NU UT WOS:000603372200001 PM 33392241 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Gómez-Pérez, AM Ruiz-Limón, P Salas-Salvadó, J Vioque, J Corella, D Fitó, M Vidal, J Atzeni, A Torres-Collado, L Alvarez-Sala, A Martínez, MA Goday, A Benaiges, D García-Gavilán, J López, MRB Moreno-Indias, I Tinahones, FJ AF Gomez-Perez, Ana Maria Ruiz-Limon, Patricia Salas-Salvado, Jordi Vioque, Jesus Corella, Dolores Fito, Montse Vidal, Josep Atzeni, Alessandro Torres-Collado, Laura Alvarez-Sala, Andrea Angeles Martinez, Maria Goday, Albert Benaiges, David Garcia-Gavilan, Jesus Bernal Lopez, Maria Rosa Moreno-Indias, Isabel Tinahones, Francisco J. TI Gut microbiota in nonalcoholic fatty liver disease: a PREDIMED-Plus trial sub analysis SO GUT MICROBES LA English DT Article DE Microbiome; metabolic liver disease; hepatic steatosis index; the Fibrosis-4 score; Mediterranean diet ID GASTRIC BYPASS; INTERVENTION; ACID AB Plain Language Summary What You Need to Know What is the context: Obesity and metabolic syndrome have been associated with nonalcoholic fatty liver disease (NAFLD). Gut microbiota and its interaction with the environment may play a key role in NAFLD. What is new: Mediterranean diet and physical activity can modify the scores for liver steatosis (HSI) and liver fibrosis (FIB-4) in only one year. A relation between the changes in these scores and gut microbiota changes was found. What is the impact: The discovery of microbiota-based biomarkers for NAFLD and the development of strategies to modulate gut microbiota in the treatment of NAFLD. To evaluate the changes in the gut microbiota associated with changes in the biochemical markers of nonalcoholic fatty liver disease (NAFLD) after a lifestyle intervention with the Mediterranean diet. Participants (n = 297) from two centers of PREDIMED-Plus trial (Prevencion con Dieta Mediterranea) were divided into three different groups based on the change tertile in the Hepatic Steatosis Index (HSI) or the Fibrosis-4 score (FIB-4) between baseline and one year of intervention. One-year changes in HSI were: tertile 1 (T1) (-24.9 to -7.51), T2 (-7.5 to -1.86), T3 (-1.85 to 13.64). The most significant differences in gut microbiota within the year of intervention were observed in the T1 and T3. According to the FIB-4, participants were categorized in non-suspected fibrosis (NSF) and with indeterminate or suspected fibrosis (SF). NSF participants showed higher abundances of Alcaligenaceae, Bacteroidaceae, Bifidobacteriaceae, Clostridiaceae, Enterobacteriaceae, Peptostreptococcaceae, Verrucomicrobiaceae compared to those with SF. Then, participants were divided depending on the FIB-4 tertile of change: T1 (-89.60 to -5.57), T2 (-5.56 to 11.4), and T3 (11.41 to 206.24). FIB-4 T1 showed a decrease in Akkermansia and an increase in Desulfovibrio. T2 had an increase in Victivallaceae, Clostridiaceae, and Desulfovibrio. T3 showed a decrease in Enterobacteriaceae, and an increase in Sutterella, Faecalibacterium, and Blautia. A relation between biochemical index changes of NAFLD/NASH (HSI and FIB-4) and gut microbiota changes were found. These observations highlight the importance of lifestyle intervention in the modulation of gut microbiota and the management of metabolic syndrome and its hepatic manifestations. C1 [Gomez-Perez, Ana Maria; Ruiz-Limon, Patricia; Moreno-Indias, Isabel; Tinahones, Francisco J.] Univ Malaga, Virgen Victoria Univ Hosp, Biomed Res Inst Malaga & Platform Nanomed IBIMA B, Dept Endocrinol & Nutr, Malaga, Spain. [Gomez-Perez, Ana Maria; Ruiz-Limon, Patricia; Salas-Salvado, Jordi; Corella, Dolores; Fito, Montse; Atzeni, Alessandro; Alvarez-Sala, Andrea; Angeles Martinez, Maria; Goday, Albert; Benaiges, David; Garcia-Gavilan, Jesus; Bernal Lopez, Maria Rosa; Moreno-Indias, Isabel; Tinahones, Francisco J.] Carlos III Hlth Inst, CIBER Physiopathol Obes & Nutr CIBEROBN, Madrid, Spain. [Salas-Salvado, Jordi; Atzeni, Alessandro; Angeles Martinez, Maria; Garcia-Gavilan, Jesus] Univ Rovira & Virgili, Dept Biochem & Biotechnol, Human Nutr Unit, Reus, Spain. [Salas-Salvado, Jordi; Atzeni, Alessandro; Angeles Martinez, Maria; Garcia-Gavilan, Jesus] Pere & Virgili Hlth Res Inst IISPV, Human Nutr Unit, Reus, Spain. [Vioque, Jesus; Torres-Collado, Laura] Univ Miguel Hernandez ISABIAL UMH, Inst Hlth & Biomed Res Alicante, Alicante, Spain. [Vioque, Jesus; Torres-Collado, Laura] Carlos III Hlth Inst, CIBER Epidemiol & Publ Hlth CIBERESP, Madrid, Spain. [Corella, Dolores; Alvarez-Sala, Andrea] Univ Valencia, Dept Prevent Med, Valencia, Spain. [Fito, Montse; Goday, Albert; Benaiges, David] Hosp Del Mar Res Inst IMIM, Cardiovasc Risk & Nutr Regicor Study Grp, Barcelona, Spain. [Vidal, Josep] Clin Univ Hosp, Endocrinol & Nutr Dept, Barcelona, Spain. [Vidal, Josep] August Pi I Sunyer Biomed Res Inst IDIBAPS, Endocrinol & Nutr Dept, Barcelona, Spain. [Bernal Lopez, Maria Rosa] Reg Univ Hosp, Inst Biomed Res Malaga IBIMA, Dept Internal Med, Malaga, Spain. C3 IBIMA Plataforma BIONAND, Instituto de Investigacion Biomedica de Malaga; Universidad de Malaga; CIBER - Centro de Investigacion Biomedica en Red; CIBEROBN; Universitat Rovira i Virgili; Universitat Rovira i Virgili; Institut d'Investigacio Sanitaria Pere Virgili (IISPV); General University Hospital of Alicante; Universidad Miguel Hernandez de Elche; Universitat d'Alacant; Instituto de Investigacion Sanitaria y Biomedica de Alicante (ISABIAL); CIBER - Centro de Investigacion Biomedica en Red; CIBERESP; University of Valencia; Hospital del Mar Research Institute; Hospital del Mar; University of Barcelona; Hospital Clinic de Barcelona; University of Barcelona; Hospital Clinic de Barcelona; IDIBAPS; IBIMA Plataforma BIONAND, Instituto de Investigacion Biomedica de Malaga; Universidad de Malaga RP Moreno-Indias, I (通讯作者)，Virgen Victoria Univ Hosp, Dept Endocrinol & Nutr, IBIMA BIONAND Platform, Campus Teatinos S-N, Malaga 29010, Spain. EM isabel.moreno@ibima.eu RI Tinahones, Francisco J/AAB-2882-2020; Benaiges, David/L-8370-2014; Vioque, Jesus/A-1066-2008; Salas-Salvadó, Jordi/C-7229-2017; Fitó Colomer, Montse/C-1822-2012; García-Gavilán, Jesús Francisco/ABG-9982-2020; Atzeni, Alessano/AAF-8431-2021; Bernal-Lopez, M/N-3564-2016; Corella, Dolores/L-9888-2014; Limon, Patricia/AAD-3424-2021; Moreno-Indias, Isabel/B-6595-2017; Vidal, Josep/MIK-6936-2025; Martínez, María Ángeles/ABH-6345-2020 OI Tinahones, Francisco J/0000-0001-6871-4403; Benaiges, David/0000-0001-5411-364X; Martínez Rodríguez, María Ángeles/0000-0001-8595-3772; Salas-Salvadó, Jordi/0000-0003-2700-7459; Fitó Colomer, Montse/0000-0002-1817-483X; Gómez Pérez, Ana María/0000-0002-2874-5894; García-Gavilán, Jesús Francisco/0000-0002-3707-5255; Atzeni, Alessano/0000-0002-1804-8606; FU CIBER Fisiopatologia de la Obesidad y Nutricion (CIBEROBN); Instituto de Salud Carlos III (ISCIII) through the Fondo de Investigacion para la Salud (FIS); European Regional Development Fund [PI13/00462, PI16/00501, PI19/00576, PI17/01441, PI14/01206, PI13/00233, PI16/00533, PI19/00017, PI14/00696, PI17/00855]; Especial Action Project [OBN16PE01]; Recercaixa [2013ACUP00194]; Generalitat Valenciana [PROMETEO 2017/17, PROMETEO 2021/21]; Ministry of Science and Innovation/ISCIII [PI19/00781]; Eat2beNICE project (European Union's Horizon 2020 research and innovation programme) [728018]; ISCIII-Madrid (Spain) [CD19/00216, CPII21/00013]; Fondo Europeo de Desarrollo Regional-FEDER; FEDER; Servicio Andaluz de Salud [B-00332014, CPII/00014]; Conselleria de Innovacion, Generalitat Valenciana [C1-0005-2020]; ISCIII [APOSTD/2020/164]; FEDER funds; ICREA under the ICREA Academia programme; H2020 Societal Challenges Programme [728018] Funding Source: H2020 Societal Challenges Programme FX This work was supported by the official Spanish Institutions for funding scientific biomedical research, CIBER Fisiopatologia de la Obesidad y Nutricion (CIBEROBN) and Instituto de Salud Carlos III (ISCIII), through the Fondo de Investigacion para la Salud (FIS), which is co-funded by the European Regional Development Fund (three coordinated FIS projects lead by JS-S: PI13/00462, PI16/00501 and PI19/00576; two led by JV: PI17/01441, PI14/01206; three led by AG: PI13/00233, PI16/00533, PI19/00017; and two led by MRBL: PI14/00696 and PI17/00855); the Especial Action Project entitled: Implementacion y evaluacion de una intervencion intensiva sobre la actividad fisica Cohorte PREDIMED-Plus grant (OBN16PE01) to JS-S; the Recercaixa (number 2013ACUP00194) grant to JS-S. DC obtained grant from the Generalitat Valenciana (PROMETEO 2017/17 and PROMETEO 2021/21) and Grant from the Ministry of Science and Innovation/ISCIII (reference: PI19/00781). Eat2beNICE project (European Union's Horizon 2020 research and innovation programme under grant agreement No 728018). PRL was supported by a "Sara Borrell" postdoctoral contract (CD19/00216) from the ISCIII-Madrid (Spain), co-financed by the Fondo Europeo de Desarrollo Regional-FEDER. IMI was supported by the "Miguel Servet Type II" program (CPII21/00013) of the ISCIII-Madrid (Spain), co-financed by the FEDER. AMGP was supported by a research contract from Servicio Andaluz de Salud (B-0033-2014). AA-S has received a post-doctoral grant (APOSTD/2020/164) from the Conselleria de Innovacion, Generalitat Valenciana. MRBL is supported by Miguel Servet II program (CPII/00014) from ISCIII and by Nicolas Monardes program (C1-0005-2020) from Servicio Andaluz de Salud, both cofunded by FEDER funds. This work is partially supported by ICREA under the ICREA Academia programme. Food companies Hojiblanca (Lucena, Spain) and Patrimonio Comunal Olivarero (Madrid, Spain) donated extra virgin olive oil; and the Almond Board of California (Modesto, CA, USA), American Pistachio Growers (Fresno, CA, USA), and Paramount Farms (Wonderful Company, LLC, Los Angeles, CA, USA) donated nuts for the PREDIMED-Pilot study. 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Peterson, Karen Padmanabhan, Vasantha Dolinoy, Dana C. TI Gestational exposure to high fat diets and bisphenol A alters metabolic outcomes in dams and offspring, but produces hepatic steatosis only in dams SO CHEMOSPHERE LA English DT Article DE Endocrine disrupting chemicals; Developmental programming; NAFLD; Sexual dimorphism; High-fat diet; Bisphenol-A ID NHANES-II SURVEY; MEDITERRANEAN DIET; LIVER-DISEASE; PERINATAL EXPOSURE; MATERNAL OBESITY; GENE-EXPRESSION; HISTONE MODIFICATIONS; DISRUPTING CHEMICALS; QUANTITATIVE DATA; NUTRIENT SOURCES AB The prevalence of non-alcoholic fatty liver disease (NAFLD) is increasing worldwide. Perinatal development is a critical window for altered, lifelong health trajectory, and evidence supports the role of perinatal programming in chronic metabolic diseases. To examine the impact of diet and bisphenol A (BPA) on the developmental trajectory of NAFLD in offspring, we exposed dams from pre-gestation through lactation to a human-relevant dose of oral BPA coupled with intake of high fat Western or Mediterranean-style diets. We assessed hepatic steatosis by quantifying hepatic triglycerides (TGs) and metabolic health by measuring body weight, relative organ weights, and serum hormone levels in dams and offspring at postnatal day 10 (PND10) and 10-months of age. In dams, consumption of the Western or Mediterranean diet increased hepatic TGs 1.7-2.4-fold, independent of BPA intake. Among offspring, both perinatal diet and BPA exposure had a greater impact on metabolic outcomes than on hepatic steatosis. At PND10, serum leptin levels were elevated 2.6-4.8-fold in pups exposed to the Mediterranean diet, with a trend for sex-specific effects on body and organ weights. At 10-months, sex-specific increases in organ weight and hormone levels were observed in mice perinatally exposed to Western + BPA or Mediterranean + BPA. These findings suggest lifestage-specific interaction of perinatal exposures to experimental diets and BPA on offspring metabolic health without effects on NAFLD later in life. Importantly, alterations in dam phenotype by diet and BPA exposure appear to impact offspring health trajectory, emphasizing the need to define dam diet in assessing effects of environmental exposures on offspring health. C1 [Marchlewicz, Elizabeth; Peterson, Karen; Padmanabhan, Vasantha; Dolinoy, Dana C.] Univ Michigan, Environm Hlth Sci, Sch Publ Hlth, Ann Arbor, MI 48109 USA. [McCabe, Carolyn; Peterson, Karen; Dolinoy, Dana C.] Univ Michigan, Nutr Sci, Sch Publ Hlth, Ann Arbor, MI 48109 USA. [Djuric, Zora] Univ Michigan, Dept Family Med, Med Sch, Ann Arbor, MI 48109 USA. [Hoenerhoff, Mark] Univ Michigan, Unit Lab Anim Med, Vivo Anim Core, Med Sch, Ann Arbor, MI 48109 USA. [Barks, John; Padmanabhan, Vasantha] Univ Michigan, Dept Pediat, Med Sch, Ann Arbor, MI 48109 USA. [Tang, Lu] Univ Pittsburgh, Dept Biostat, Pittsburgh, PA USA. [Song, Peter X.] Univ Michigan, Dept Biostat, Sch Publ Hlth, Ann Arbor, MI 48109 USA. [Padmanabhan, Vasantha] Univ Michigan, Dept Obstet & Gynecol, Med Sch, Ann Arbor, MI 48109 USA. C3 University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; University of Michigan System; University of Michigan; University of Michigan System; University of Michigan RP Dolinoy, DC (通讯作者)，Univ Michigan, Sch Publ Hlth, NSF Int Chair Environm Hlth Sci Environm Hlth Sci, 1415 Washington Hts, Ann Arbor, MI 48109 USA. EM ddolinoy@umich.edu RI Padmanabhan, Vasantha/C-8558-2017; Tang, Lu/AAM-1941-2021; Djuric, Zora/H-5147-2013 OI Barks, John/0000-0003-1320-905X; Tang, Lu/0000-0001-6143-9314; Djuric, Zora/0000-0002-8886-8853 FU University of Michigan (UM) NIEHS/EPA Children's Environmental Health and Disease Prevention Center [P01 ES022844/RD83543601]; NIEHS [R35 ES031686]; Michigan Lifestage Environmental Exposures and Disease (M-LEEaD) NIEHS Core Center [P30 ES017885]; Rogel Cancer Center [P30 CA046592]; MDRC Chemistry Lab [P30 DK020572]; UM Institutional and Individual Training Grants [T32 ES007062, T32 HD079342, F31 ES025101]; Eunice Kennedy Shriver National Institute of Child Health and Human Development [T32HD079342] Funding Source: NIH RePORTER; National Cancer Institute [P30CA046592] Funding Source: NIH RePORTER; National Institute of Diabetes and Digestive and Kidney Diseases [P30DK020572, P30DK089503] Funding Source: NIH RePORTER; National Institute of Environmental Health Sciences [R35ES031686, P30ES017885, T32ES007062] Funding Source: NIH RePORTER FX This work was supported by the University of Michigan (UM) NIEHS/EPA Children's Environmental Health and Disease Prevention Center P01 ES022844/RD83543601, NIEHS R35 ES031686, the Michigan Lifestage Environmental Exposures and Disease (M-LEEaD) NIEHS Core Center (P30 ES017885), the Rogel Cancer Center (P30 CA046592), and the MDRC Chemistry Lab (P30 DK020572), as well as UM Institutional and Individual Training Grants T32 ES007062 (EHM), T32 HD079342 (EHM), and F31 ES025101 (EHM). 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Chemosphere PD JAN PY 2022 VL 286 AR 131645 DI 10.1016/j.chemosphere.2021.131645 EA AUG 2021 PN 2 PG 12 WC Environmental Sciences WE Science Citation Index Expanded (SCI-EXPANDED) SC Environmental Sciences & Ecology GA WD2UF UT WOS:000704801700002 PM 34426127 OA Green Submitted DA 2026-02-02 ER PT J AU Katsagoni, CN Papatheodoridis, GV Papageorgiou, MV Ioannidou, P Deutsch, M Alexopoulou, A Papadopoulos, N Fragopoulou, E Kontogianni, MD AF Katsagoni, Christina N. Papatheodoridis, George V. Papageorgiou, Maria-Vasiliki Ioannidou, Panagiota Deutsch, Melanie Alexopoulou, Alexandra Papadopoulos, Nikolaos Fragopoulou, Elisabeth Kontogianni, Meropi D. TI A "healthy diet-optimal sleep" lifestyle pattern is inversely associated with liver stiffness and insulin resistance in patients with nonalcoholic fatty liver disease SO APPLIED PHYSIOLOGY NUTRITION AND METABOLISM LA English DT Article DE NAFLD; insulin resistance; lifestyle pattern; sleep; diet ID METABOLIC SYNDROME; MEDITERRANEAN DIET; CIGARETTE-SMOKING; PHYSICAL-ACTIVITY; RISK; DURATION; PLASMA; NAFLD; EPIDEMIOLOGY; PATHOGENESIS AB Several lifestyle habits have been described as risk factors for nonalcoholic fatty liver disease (NAFLD). Given that both healthy and unhealthy habits tend to cluster, the aim of this study was to identify lifestyle patterns and explore their potential associations with clinical characteristics of individuals with NAFLD. One hundred and thirty-six consecutive patients with ultrasound-proven NAFLD were included. Diet and physical activity level were assessed through appropriate questionnaires. Habitual night sleep hours and duration of midday naps were recorded. Optimal sleep duration was defined as sleep hours >= 7 and <= 9 h/day. Lifestyle patterns were identified using principal component analysis. Eight components were derived explaining 67% of total variation of lifestyle characteristics. Lifestyle pattern 3, namely high consumption of low-fat dairy products, vegetables, fish, and optimal sleep duration was negatively associated with insulin resistance (beta = -1.66, P = 0.008) and liver stiffness (beta = -1.62, P = 0.05) after controlling for age, sex, body mass index, energy intake, smoking habits, adiponectin, and tumor necrosis factor-alpha. Lifestyle pattern 1, namely high consumption of full-fat dairy products, refined cereals, potatoes, red meat, and high television viewing time was positively associated with insulin resistance (beta = 1.66, P = 0.005), although this association was weakened after adjusting for adiponectin and tumor necrosis factor-alpha. A " healthy diet-optimal sleep" lifestyle pattern was beneficially associated with insulin resistance and liver stiffness in NAFLD patients independent of body weight status and energy intake. C1 [Katsagoni, Christina N.; Fragopoulou, Elisabeth; Kontogianni, Meropi D.] Harokopio Univ, Sch Hlth Sci & Educ, Dept Nutr & Dietet, 70 El Venizelou Str, Athens 17671, Greece. [Papatheodoridis, George V.; Papageorgiou, Maria-Vasiliki; Ioannidou, Panagiota; Deutsch, Melanie; Alexopoulou, Alexandra; Papadopoulos, Nikolaos] Natl & Kapodistrian Univ Athens, Laiko Gen Hosp Athens, Sch Med, Athens 11527, Greece. C3 Harokopio University Athens; National & Kapodistrian University of Athens; Laiko General Hospital RP Katsagoni, CN (通讯作者)，Harokopio Univ, Sch Hlth Sci & Educ, Dept Nutr & Dietet, 70 El Venizelou Str, Athens 17671, Greece. EM christina.katsagoni@gmail.com RI PAPADOPOULOS, NIKOLAOS/ABE-1774-2021; Kontogianni, Meropi/AAN-6530-2021; Fragopoulou, Elizabeth/AAN-2050-2021; ALEXOPOULOU, ALEXANA/AAB-7698-2021; Papatheodoridis, George/A-4603-2008; Maria Melanie, Deutsch/I-3279-2019; Papadopoulos, Nikolaos/ABE-1774-2021 OI PAPADOPOULOS, NIKOLAOS/0000-0002-8702-1685; Katsagoni, Christina N/0000-0003-4474-328X; Kontogianni, Meropi/0000-0003-3168-8867; ALEXOPOULOU, ALEXANA/0000-0003-1991-7436; Papatheodoridis, George/0000-0002-3518-4060; Maria Melanie, Deutsch/0000-0002-3410-8226; Papadopoulos, Nikolaos/0000-0002-4448-3468 FU State Scholarships Foundation (I.K.Y.) FX The authors have no conflicts of interest to declare. Christina N. Katsagoni has received a Fellowship of Excellence for Post-graduate Research in Greece-Siemens Program, awarded by the State Scholarships Foundation (I.K.Y.). 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Physiol. Nutr. Metab. PD MAR PY 2017 VL 42 IS 3 BP 250 EP 256 DI 10.1139/apnm-2016-0492 PG 7 WC Nutrition & Dietetics; Physiology; Sport Sciences WE Science Citation Index Expanded (SCI-EXPANDED) SC Nutrition & Dietetics; Physiology; Sport Sciences GA EM8DH UT WOS:000395541000004 PM 28133993 OA Green Accepted DA 2026-02-02 ER PT J AU Vachliotis, I Goulas, A Papaioannidou, P Polyzos, SA AF Vachliotis, Ilias Goulas, Antonis Papaioannidou, Paraskevi Polyzos, Stergios A. TI Nonalcoholic fatty liver disease: lifestyle and quality of life SO HORMONES-INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM LA English DT Review DE Diet; Lifestyle; Nonalcoholic fatty liver disease; Nonalcoholic steatohepatitis; Physical activity; Quality of life ID INSULIN-RESISTANCE; EXERCISE; DIAGNOSIS AB Nonalcoholic fatty liver disease (NAFLD) is a metabolic disorder whose current rapidly expanding prevalence is causing it to develop into a major global health concern. NAFLD is closely linked to the modern, unhealthy lifestyle. The Western diet, characterized by excessive energy intake, frequent consumption of red meat, processed meat and foods, soft drinks, and sugar-sweetened beverages (SSBs), irregular meal distribution throughout the day, and unhealthy ways of cooking, predisposes to development of NAFLD. Low levels of physical activity and prolonged sedentary time are additional lifestyle risk factors for NAFLD. Given the present lack of effective pharmacological treatment, lifestyle modifications are regarded as the cornerstone of NAFLD management. Reducing daily calorie intake together with following the Mediterranean diet (MD) is an increasingly accepted approach. Furthermore, increasing the level of physical activity and limiting sedentary behavior are additional measures proposed to improve the outcomes of the disease. Apart from being affected by lifestyle, NAFLD may also affect patients' quality of life (QoL), mostly in the domain of physical function. In this regard, while the early and more benign form of the disease, i.e., simple hepatic steatosis, may not affect QoL, there is evidence, though conflicting, of the impact of nonalcoholic steatohepatitis (NASH) on this index, with, however, most studies showing that QoL is consistently affected in advanced disease, i.e., hepatic fibrosis, cirrhosis, and hepatocellular carcinoma. Considering all the above, appropriate management of lifestyle is likely to attenuate the severity of the disease and improve the QoL of NAFLD patients. C1 [Vachliotis, Ilias] Gen Ioannis Makrygiannis Camp, Battal Med Corps 80, Pyli, Kos, Greece. [Vachliotis, Ilias; Goulas, Antonis; Papaioannidou, Paraskevi; Polyzos, Stergios A.] Aristotle Univ Thessaloniki, Sch Med, Lab Pharmacol 1, Thessaloniki, Greece. C3 Aristotle University of Thessaloniki RP Vachliotis, I (通讯作者)，Gen Ioannis Makrygiannis Camp, Battal Med Corps 80, Pyli, Kos, Greece.; Vachliotis, I (通讯作者)，Aristotle Univ Thessaloniki, Sch Med, Lab Pharmacol 1, Thessaloniki, Greece. EM ivachliot@auth.gr RI ; Papaioannidou, Paraskevi/D-9864-2011; Polyzos, Stergios/H-2844-2019 OI Vachliotis, Ilias D/0000-0001-8550-8652; Papaioannidou, Paraskevi/0000-0001-8880-0288; CR Akhlaghi M, 2020, J DIABETES METAB DIS, V19, P575, DOI 10.1007/s40200-019-00475-2 Aller R, 2015, NUTR HOSP, V32, P2518 Asgari-Taee F, 2019, EUR J NUTR, V58, P1759, DOI 10.1007/s00394-018-1711-4 Assimakopoulos K, 2018, J PSYCHOSOM RES, V112, P73, DOI 10.1016/j.jpsychores.2018.07.004 Athyros VG, 2017, METABOLISM, V71, P17, DOI 10.1016/j.metabol.2017.02.014 Baker CJ, 2021, J DIABETES, V13, P63, DOI 10.1111/1753-0407.13086 Chung M, 2014, AM J CLIN NUTR, V100, P833, DOI 10.3945/ajcn.114.086314 Cortesi PA, 2020, LIVER INT, V40, P2630, DOI 10.1111/liv.14647 Deng YY, 2021, PUBLIC HEALTH NUTR, V24, P5081, DOI 10.1017/S1368980021000902 EASL, 2016, OBESITY FACTS, V9, P65, DOI 10.1159/000443344 Garcêz LS, 2021, NUTR REV, V79, P1321, DOI 10.1093/nutrit/nuaa146 Golabi P, 2016, WORLD J GASTROENTERO, V22, P6318, DOI 10.3748/wjg.v22.i27.6318 Hashida R, 2017, J HEPATOL, V66, P142, DOI 10.1016/j.jhep.2016.08.023 Zadeh SH, 2021, J GASTROEN HEPATOL, V36, P1470, DOI 10.1111/jgh.15363 He KY, 2020, BRIT J NUTR, V124, P1, DOI 10.1017/S0007114520000914 Hydes T, 2021, FRONT NUTR, V8, DOI 10.3389/fnut.2021.640557 Ivancovsky-Wajcman D, 2019, CLIN TRANSL GASTROEN, V10, DOI 10.14309/ctg.0000000000000040 Kellow NJ, 2013, EUR J CLIN NUTR, V67, P239, DOI 10.1038/ejcn.2012.220 Kim D, 2020, HEPATOLOGY, V72, P1556, DOI 10.1002/hep.31158 Koch M, 2015, J EPIDEMIOL COMMUN H, V69, P732, DOI 10.1136/jech-2014-204989 Kontogianni MD, 2014, CLIN NUTR, V33, P678, DOI 10.1016/j.clnu.2013.08.014 Koopman KE, 2014, HEPATOLOGY, V60, P545, DOI 10.1002/hep.27149 Makri E, 2021, ARCH MED RES, V52, P25, DOI 10.1016/j.arcmed.2020.11.010 Moosavian SP, 2020, CLIN NUTR ESPEN, V35, P40, DOI 10.1016/j.clnesp.2019.10.008 Noureddin M, 2020, HEPATOLOGY, V71, P1940, DOI 10.1002/hep.30967 Oliveira CP, 2016, J DIABETES RES, V2016, DOI 10.1155/2016/4597246 Orci LA, 2016, CLIN GASTROENTEROL H, V14, P1398, DOI 10.1016/j.cgh.2016.04.036 Palma-Duran SA, 2018, METABOLISM, V83, P120, DOI 10.1016/j.metabol.2018.01.023 Perdomo CM, 2019, NUTRIENTS, V11, DOI 10.3390/nu11030677 Polyzos SA, 2020, METABOLISM, V111, DOI 10.1016/j.metabol.2020.154203 Polyzos SA, 2019, METABOLISM, V92, P82, DOI 10.1016/j.metabol.2018.11.014 Polyzos SA, 2017, MINERVA ENDOCRINOL, V42, P92, DOI 10.23736/S0391-1977.16.02563-3 Polyzos SA, 2014, METABOLISM, V63, P161, DOI 10.1016/j.metabol.2013.10.010 Polyzos SA, 2012, J CLIN GASTROENTEROL, V46, P272, DOI 10.1097/MCG.0b013e31824587e0 Polyzos SA, 2009, CURR MOL MED, V9, P299, DOI 10.2174/156652409787847191 Saeed N, 2019, NUTRIENTS, V11, DOI 10.3390/nu11123064 Sayiner M, 2016, BMJ OPEN GASTROENTER, V3, DOI 10.1136/bmjgast-2016-000106 Tapper EB, 2016, HEPATOLOGY, V63, P1184, DOI 10.1002/hep.28416 Torres MCP, 2019, NUTRIENTS, V11, DOI 10.3390/nu11122971 van der Windt Dirk J., 2018, Gene Expression-The Journal of Liver Research, V18, P89, DOI [10.3727/105221617x15124844266408, 10.3727/105221617X15124844266408] Vilar-Gomez E., 2022, HEPATOLOGY, V75, P1491, DOI [10.1002/hep.32207, DOI 10.1002/hep.32207] Wang ST, 2020, BMC GASTROENTEROL, V20, DOI 10.1186/s12876-020-01204-3 Wehmeyer MH, 2016, MEDICINE, V95, DOI 10.1097/MD.0000000000003887 Whitsett M, 2015, WORLD J HEPATOL, V7, P2041, DOI 10.4254/wjh.v7.i16.2041 Yamamura S, 2021, J GASTROEN HEPATOL, V36, P629, DOI 10.1111/jgh.15172 Younossi ZM, 2020, HEPATOL COMMUN, V4, P1637, DOI 10.1002/hep4.1581 Younossi ZM, 2019, CLIN GASTROENTEROL H, V17, P2552, DOI 10.1016/j.cgh.2019.02.024 Younossi ZM, 2019, J CLIN GASTROENTEROL, V53, P331, DOI 10.1097/MCG.0000000000001179 Younossi ZM, 2018, LIVER INT, V38, P1849, DOI 10.1111/liv.13706 Zou TT, 2018, EUR J GASTROEN HEPAT, V30, P747, DOI 10.1097/MEG.0000000000001135 NR 50 TC 43 Z9 46 U1 0 U2 19 PU SPRINGER INT PUBL AG PI CHAM PA GEWERBESTRASSE 11, CHAM, CH-6330, SWITZERLAND SN 1109-3099 EI 2520-8721 J9 HORM-INT J ENDOCRINO JI Horm.-Int. J. Endocrinol. Metab. PD MAR PY 2022 VL 21 IS 1 BP 41 EP 49 DI 10.1007/s42000-021-00339-6 EA DEC 2021 PG 9 WC Endocrinology & Metabolism WE Science Citation Index Expanded (SCI-EXPANDED) SC Endocrinology & Metabolism GA YU4GV UT WOS:000724661400001 PM 34854066 DA 2026-02-02 ER PT J AU Tana, C Ballestri, S Ricci, F Di Vincenzo, A Ticinesi, A Gallina, S Giamberardino, MA Cipollone, F Sutton, R Vettor, R Fedorowski, A Meschi, T AF Tana, Claudio Ballestri, Stefano Ricci, Fabrizio Di Vincenzo, Angelo Ticinesi, Andrea Gallina, Sabina Giamberardino, Maria Adele Cipollone, Francesco Sutton, Richard Vettor, Roberto Fedorowski, Artur Meschi, Tiziana TI Cardiovascular Risk in Non-Alcoholic Fatty Liver Disease: Mechanisms and Therapeutic Implications SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH LA English DT Review DE non-alcoholic fatty liver disease; cardiovascular disease; metabolic syndrome; cardiovascular risk factors ID TYPE-2 DIABETES-MELLITUS; LIFE-STYLE INTERVENTIONS; CORONARY-HEART-DISEASE; ACUTE ISCHEMIC-STROKE; LEPTIN RECEPTOR GENE; HEPATIC STEATOSIS; CONFERS SUSCEPTIBILITY; ATRIAL-FIBRILLATION; MEDITERRANEAN DIET; CLINICAL-OUTCOMES AB New evidence suggests that non-alcoholic fatty liver disease (NAFLD) has a strong multifaceted relationship with diabetes and metabolic syndrome, and is associated with increased risk of cardiovascular events, regardless of traditional risk factors, such as hypertension, diabetes, dyslipidemia, and obesity. Given the pandemic-level rise of NAFLD-in parallel with the increasing prevalence of obesity and other components of the metabolic syndrome-and its association with poor cardiovascular outcomes, the question of how to manage NAFLD properly, in order to reduce the burden of associated incident cardiovascular events, is both timely and highly relevant. This review aims to summarize the current knowledge of the association between NAFLD and cardiovascular disease, and also to discuss possible clinical strategies for cardiovascular risk assessment, as well as the spectrum of available therapeutic strategies for the prevention and treatment of NAFLD and its downstream events. C1 [Tana, Claudio; Ticinesi, Andrea; Meschi, Tiziana] Univ Hosp Parma, Internal Med & Crit Subacute Care Unit, Med Geriatr Rehabil Dept, I-43121 Parma, Italy. [Tana, Claudio; Ticinesi, Andrea; Meschi, Tiziana] Univ Hosp Parma, Dept Med & Surg, I-43121 Parma, Italy. [Ballestri, Stefano] Pavullo Hosp, Internal Med Unit, Azienda USL, I-41026 Modena, Italy. [Ricci, Fabrizio; Gallina, Sabina] Univ G dAnnunzio, Inst Adv Biomed Technol, Dept Neurosci Imaging & Clin Sci, I-66100 Chieti, Italy. [Ricci, Fabrizio] Lund Univ, Dept Clin Sci, Fac Med, SE-20502 Malmo, Sweden. [Ricci, Fabrizio; Di Vincenzo, Angelo] Fdn Villa Serena Ric, Viale Leonardo Petruzzi 42, I-65013 Citta S Angelo, Italy. [Giamberardino, Maria Adele] Univ G dAnnunzio, Geriatr Clin, Dept Med & Sci Aging, I-66100 Chieti, Italy. [Giamberardino, Maria Adele] Univ G dAnnunzio, CeSI MeT, I-66100 Chieti, Italy. [Cipollone, Francesco] Univ G dAnnunzio, European Ctr Excellence Hypertens Dyslipidemia &, I-66100 Chieti, Italy. [Cipollone, Francesco] Univ G dAnnunzio, Dept Med & Sci Aging, I-66100 Chieti, Italy. [Sutton, Richard] Imperial Coll, Natl Heart & Lung Inst, Hammersmith Hosp Campus,Ducane Rd, London W12 0NN, England. [Vettor, Roberto] Univ Padua, Dept Med, Ctr Study & Integrated Treatment Obes, I-35122 Padua, Italy. [Fedorowski, Artur] Skane Univ Hosp, Clin Res Ctr, Dept Cardiol, SE-20502 Malmo, Sweden. C3 University of Parma; University Hospital of Parma; University of Parma; University Hospital of Parma; G d'Annunzio University of Chieti-Pescara; Lund University; G d'Annunzio University of Chieti-Pescara; G d'Annunzio University of Chieti-Pescara; G d'Annunzio University of Chieti-Pescara; G d'Annunzio University of Chieti-Pescara; Imperial College London; University of Padua; Lund University; Skane University Hospital RP Ricci, F (通讯作者)，Univ G dAnnunzio, Inst Adv Biomed Technol, Dept Neurosci Imaging & Clin Sci, I-66100 Chieti, Italy.; Ricci, F (通讯作者)，Lund Univ, Dept Clin Sci, Fac Med, SE-20502 Malmo, Sweden.; Ricci, F (通讯作者)，Fdn Villa Serena Ric, Viale Leonardo Petruzzi 42, I-65013 Citta S Angelo, Italy. EM fabrizio.ricci@unich.it RI Cipollone, Francesco/AAC-5698-2022; VETTOR, ROBERTO/K-7121-2016; Fedorowski, Artur/I-3937-2019; Meschi, Tiziana/K-5032-2016; Tana, Claudio/AFU-7973-2022; Ticinesi, Anea/K-5017-2016; Di Vincenzo, Angelo/V-5972-2019; ballestri, stefano/AAQ-1541-2021; Sutton, Richard/ABC-4436-2020; Ricci, Fabrizio/AAM-2464-2021 OI Fedorowski, Artur/0000-0002-5352-6327; Tana, Claudio/0000-0002-9162-7866; Ticinesi, Anea/0000-0001-9171-8592; Di Vincenzo, Angelo/0000-0002-7678-5671; ballestri, stefano/0000-0002-1424-7894; Sutton, Richard/0000-0002-5710-1094; Ricci, Fabrizio/0000-0002-1401-6623 CR Abdeldyem SM, 2017, J CLIN LIPIDOL, V11, P915, DOI 10.1016/j.jacl.2017.04.115 Abdelhamid K, 2018, ARAB J GEOSCI, V11, DOI 10.1007/s12517-017-3380-7 Ajmera VH, 2017, HEPATOLOGY, V65, P2090, DOI 10.1002/hep.29055 Al-Mallah M, 2010, CARDIOL J, V17, P448 Alkhouri N, 2010, DIGEST DIS SCI, V55, P2644, DOI 10.1007/s10620-009-1075-y Anania C, 2018, WORLD J GASTROENTERO, V24, P2083, DOI 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J. Environ. Res. Public Health PD SEP 1 PY 2019 VL 16 IS 17 AR 3104 DI 10.3390/ijerph16173104 PG 19 WC Environmental Sciences; Public, Environmental & Occupational Health WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI) SC Environmental Sciences & Ecology; Public, Environmental & Occupational Health GA IZ4EQ UT WOS:000487037500099 PM 31455011 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Tsamos, G Vasdeki, D Koufakis, T Michou, V Makedou, K Tzimagiorgis, G AF Tsamos, Georgios Vasdeki, Dimitra Koufakis, Theocharis Michou, Vassiliki Makedou, Kali Tzimagiorgis, Georgios TI Therapeutic Potentials of Reducing Liver Fat in Non-Alcoholic Fatty Liver Disease: Close Association with Type 2 Diabetes SO METABOLITES LA English DT Review DE fatty liver disease; fibrosis; resolution of NAFLD; diabetes mellitus; lifestyle approaches; glucose-lowering drugs ID RECEPTOR AGONIST TIRZEPATIDE; INSULIN SENSITIVITY; PHYSICAL-ACTIVITY; WEIGHT-LOSS; BARIATRIC SURGERY; ADIPOSE-TISSUE; LIFE-STYLE; AMERICAN ASSOCIATION; TRIGLYCERIDE CONTENT; MEDITERRANEAN DIET AB Nonalcoholic fatty liver disease (NAFLD), the most widespread chronic liver disease worldwide, confers a significant burden on health systems and leads to increased mortality and morbidity through several extrahepatic complications. NAFLD comprises a broad spectrum of liver-related disorders, including steatosis, cirrhosis, and hepatocellular carcinoma. It affects almost 30% of adults in the general population and up to 70% of people with type 2 diabetes (T2DM), sharing common pathogenetic pathways with the latter. In addition, NAFLD is closely related to obesity, which acts in synergy with other predisposing conditions, including alcohol consumption, provoking progressive and insidious liver damage. Among the most potent risk factors for accelerating the progression of NAFLD to fibrosis or cirrhosis, diabetes stands out. Despite the rapid rise in NAFLD rates, identifying the optimal treatment remains a challenge. Interestingly, NAFLD amelioration or remission appears to be associated with a lower risk of T2DM, indicating that liver-centric therapies could reduce the risk of developing T2DM and vice versa. Consequently, assessing NAFLD requires a multidisciplinary approach to identify and manage this multisystemic clinical entity early. With the continuously emerging new evidence, innovative therapeutic strategies are being developed for the treatment of NAFLD, prioritizing a combination of lifestyle changes and glucose-lowering medications. Based on recent evidence, this review scrutinizes all practical and sustainable interventions to achieve a resolution of NAFLD through a multimodal approach. C1 [Tsamos, Georgios] Norfolk & Norwich Univ Hosp, Div Gastroenterol, Norwich NR4 7UY, England. [Vasdeki, Dimitra; Koufakis, Theocharis] Aristotle Univ Thessaloniki, AHEPA Univ Hosp, Med Sch, Div Endocrinol & Metab, Thessaloniki 54636, Greece. [Vasdeki, Dimitra; Koufakis, Theocharis] Aristotle Univ Thessaloniki, AHEPA Univ Hosp, Med Sch, Diabet Ctr,Dept Internal Med 1, Thessaloniki 54636, Greece. [Michou, Vassiliki] Aristotle Univ Thessaloniki, Sch Phys Educ & Sport Sci, Sports Med Lab, Thessaloniki 57001, Greece. [Makedou, Kali; Tzimagiorgis, Georgios] Aristotle Univ Thessaloniki, AHEPA Univ Hosp, Med Sch, Lab Biol Chem, Thessaloniki 54636, Greece. C3 Norfolk & Norwich University Hospitals NHS Foundation Trust; Norfolk & Norwich University Hospital; Aristotle University of Thessaloniki; Ahepa University Hospital; Aristotle University of Thessaloniki; Ahepa University Hospital; Aristotle University of Thessaloniki; Aristotle University of Thessaloniki; Ahepa University Hospital RP Koufakis, T (通讯作者)，Aristotle Univ Thessaloniki, AHEPA Univ Hosp, Med Sch, Div Endocrinol & Metab, Thessaloniki 54636, Greece.; Koufakis, T (通讯作者)，Aristotle Univ Thessaloniki, AHEPA Univ Hosp, Med Sch, Diabet Ctr,Dept Internal Med 1, Thessaloniki 54636, Greece. 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Metabolites PD APR PY 2023 VL 13 IS 4 AR 517 DI 10.3390/metabo13040517 PG 20 WC Biochemistry & Molecular Biology WE Science Citation Index Expanded (SCI-EXPANDED) SC Biochemistry & Molecular Biology GA E7OQ4 UT WOS:000977398100001 PM 37110175 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Doustmohammadian, A Saeidlou, SN Esfandyari, S Gholizadeh, E Maadi, M Motamed, N Ajdarkosh, H Khoonsari, M Clark, CCT Zamani, F AF Doustmohammadian, Azam Nouri Saeidlou, Sakineh Esfandyari, Saeed Gholizadeh, Esmaeel Maadi, Mansooreh Motamed, Nima Ajdarkosh, Hossein Khoonsari, Mahmoodreza Clark, Cain C. T. Zamani, Farhad TI Dietary Acid Load (DAL), Glycated Hemoglobin A1c (HbA1c), and Metabolic Syndrome (MeS) Mediate the Association of the Adherence to the Dietary Approaches to Stopping Hypertension (DASH) and Mediterranean Diet (MeD) With Nonalcoholic Fatty Liver Disease SO FRONTIERS IN NUTRITION LA English DT Article DE Mediterranean diet; DASH; NAFLD; dietary acid load; HbA1c; metabolic syndrome; structural equation model ID SURFACE-AREA; RISK-FACTORS; NAFLD; PREVALENCE; NUTRITION; PATTERN; WEIGHT; METAANALYSIS; CHILDREN; CHOICE AB The study aimed to investigate the association of adults adhering to Dietary Approaches to Stop Hypertension (DASH) and Mediterranean diet (MeD) with nonalcoholic fatty liver disease (NAFLD) using structural equation modeling (SEM) in Iran. In this population-based cross-sectional study, 3,220 adults (44.65% female) aged >= 18 years were selected from the Amol Cohort Study (AmolCS). The dietary intakes were assessed by a validated 168-item semi-quantitative food-frequency questionnaire (FFQ). Residual method energy adjustment of MeD and DASH scores were calculated. Demographic characteristics and anthropometric and laboratory measurements were collected. NAFLD was diagnosed by an expert radiologist via ultrasound sonography. Based on the primary hypothesis, DASH, MeD, and NAFLD were fitted into models. Metabolic syndrome (MeS) as a potential risk factor directly affected NAFLD risk in all these models. In both genders, the higher adherence to DASH negatively affected NAFLD risk indirectly through the two following paths. (1) Dietary acid load (DAL) and metabolic syndrome (2) DAL and hemoglobin A1c (HbA1c). In addition, the higher DAL positively affected NAFLD risk among male participants indirectly via increasing HbA1c level and MeS (from DAL to HbA1c: beta = 0.07, P < 0.001; from HbA1c to MeS: beta = 0.10, P < 0.001). Similarly, in both genders, the relationship between MeD and NAFLD was mediated through (1) DAL, HbA1c, and MeS and (2) DAL and MeS. Further, among male participants, the MeD and NAFLD risk were also associated via the mediators of HbA1c and MeS. In female participants, the higher MeD score was directly associated with a reduction of NAFLD risk (beta = -0.07, P = 0.008). The present study found three important mediators, including DAL, HbA1c, and MeS, in the association of DASH and MeD scores with NAFLD risk. Preventive and therapeutic interventions should target the mediators, including DAL, HbA1c, MeS, and its components, to reduce NAFLD incidence in the general population. C1 [Doustmohammadian, Azam; Gholizadeh, Esmaeel; Maadi, Mansooreh; Ajdarkosh, Hossein; Khoonsari, Mahmoodreza; Zamani, Farhad] Iran Univ Med Sci, Gastrointestinal & Liver Dis Res Ctr, Tehran, Iran. [Nouri Saeidlou, Sakineh] Urmia Univ Med Sci, Food & Beverages Safety Res Ctr, Orumiyeh, Iran. [Esfandyari, Saeed] Asadabad Sch Med Sci, Hamadan, Iran. [Motamed, Nima] Zanjan Univ Med Sci, Dept Social Med, Zanjan, Iran. [Clark, Cain C. T.] Coventry Univ, Ctr Intelligent Healthcare, Coventry, England. C3 Iran University of Medical Sciences; Urmia University of Medical Sciences; Coventry University RP Zamani, F (通讯作者)，Iran Univ Med Sci, Gastrointestinal & Liver Dis Res Ctr, Tehran, Iran. EM zamani.farhad@gmail.com RI Clark, Cain/I-4480-2019; Motamed, Nima/N-6095-2016; saeidlou, sakineh/D-3273-2017; Doustmohammadian, Azam/HNQ-0687-2023; Zamani, Farhad/ABH-8503-2020; Gholizadeh, Esmaeel/HKP-0088-2023; Khonsari, Mahmoodreza/AAP-9998-2021 OI Clark, Cain/0000-0002-6610-4617; Doustmohammadian, Azam/0000-0001-6249-2520; FU Gastrointestinal and Liver Diseases Research Center (GILDRC); Iran University of Medical Sciences (IUMS) [99-2-30-19054] FX This research was conducted by a grant from the Gastrointestinal and Liver Diseases Research Center (GILDRC), Iran University of Medical Sciences (IUMS) (Grant No. 99-2-30-19054). The funder had no role in the design of the study, data collection, analysis, interpretation of data, and the writing of this manuscript. 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Nutr. PD JUL 7 PY 2022 VL 9 AR 921415 DI 10.3389/fnut.2022.921415 PG 12 WC Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Nutrition & Dietetics GA 3E1ZK UT WOS:000829787900001 PM 35873411 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Gudan, A Kozlowska-Petriczko, K Wunsch, E Bodnarczuk, T Stachowska, E AF Gudan, Anna Kozlowska-Petriczko, Katarzyna Wunsch, Ewa Bodnarczuk, Tomasz Stachowska, Ewa TI Small Intestinal Bacterial Overgrowth and Non-Alcoholic Fatty Liver Disease: What Do We Know in 2023? SO NUTRIENTS LA English DT Review DE NAFLD; gut-liver axis; SIBO; gut dysbiosis; probiotics; nutrition ID IRRITABLE-BOWEL-SYNDROME; MEDITERRANEAN DIET; GUT MICROBIOME; BILE-ACID; FUEL METABOLISM; NAFLD PATIENTS; SATURATED FAT; FODMAP DIET; STEATOHEPATITIS; INFLAMMATION AB Non-alcoholic fatty liver disease (NAFLD) is a chronic liver disease associated with the pathological accumulation of lipids inside hepatocytes. Untreated NAFL can progress to non-alcoholic hepatitis (NASH), followed by fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). The common denominator of the above-mentioned metabolic disorders seems to be insulin resistance, which occurs in NAFLD patients. Obesity is the greatest risk factor for lipid accumulation inside hepatocytes, but a part of the NAFLD patient population has a normal body weight according to the BMI index. Obese people with or without NAFLD have a higher incidence of small intestinal bacterial overgrowth (SIBO), and those suffering from NAFLD show increased intestinal permeability, including a more frequent presence of bacterial overgrowth in the small intestine (SIBO). The health consequences of SIBO are primarily malabsorption disorders (vitamin B12, iron, choline, fats, carbohydrates and proteins) and bile salt deconjugation. Undetected and untreated SIBO may lead to nutrient and/or energy malnutrition, thus directly impairing liver function (e.g., folic acid and choline deficiency). However, whether SIBO contributes to liver dysfunction, decreased intestinal barrier integrity, increased inflammation, endotoxemia and bacterial translocation is not yet clear. In this review, we focus on gut-liver axis and discuss critical points, novel insights and the role of nutrition, lifestyle, pre- and probiotics, medication and supplements in the therapy and prevention of both SIBO and NAFLD. C1 [Gudan, Anna; Stachowska, Ewa] Pomeranian Med Univ, Dept Human Nutr & Metabol, PL-71460 Szczecin, Poland. [Kozlowska-Petriczko, Katarzyna; Wunsch, Ewa] Pomeranian Med Univ, Dept Translat Med, PL-71211 Szczecin, Poland. [Bodnarczuk, Tomasz] Artimed, Ks Piotra Sciegiennego 27, PL-70354 Szczecin, Poland. C3 Pomeranian Medical University; Pomeranian Medical University RP Stachowska, E (通讯作者)，Pomeranian Med Univ, Dept Human Nutr & Metabol, PL-71460 Szczecin, Poland. EM ewa.stachowska@pum.edu.pl RI Kozlowska-Petriczko, Katarzyna/AFS-8413-2022; Wunsch, Ewa/A-8487-2015; Gudan, Anna/CBJ-5392-2022; Stachowska, Ewa/G-9521-2017 OI Kozlowska-Petriczko, Katarzyna/0000-0002-2429-4643; Wunsch, Ewa/0000-0001-8740-5243; Gudan, Anna/0000-0002-7052-0189; Stachowska, Ewa/0000-0002-4009-1977 FU program of the Minister of Science and Higher Education under the name "REGIONALNA INICJATYWA DOSKONALOSCI" in 2019-2022 [002/RID/2018/19] FX The project is financed under the program of the Minister of Science and Higher Education under the name "REGIONALNA INICJATYWA DOSKONALOSCI" in 2019-2022 (Project No. 002/RID/2018/19, financing amount PLN 12,000,000). 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Steck, Susan E. Li, Xiaoguang Xiang, Yong-Bing Wang, Hui TI The role of dietary factors in nonalcoholic fatty liver disease to hepatocellular carcinoma progression: A systematic review SO CLINICAL NUTRITION LA English DT Review DE Dietary factors; Chronic liver diseases; NAFLD-to-HCC progression; Systematic review; Observational studies ID RED MEAT CONSUMPTION; COFFEE CONSUMPTION; RISK-FACTORS; LIFE-STYLE; VEGETABLE CONSUMPTION; INVERSE ASSOCIATION; PROSPECTIVE COHORT; TEA CONSUMPTION; SUBSEQUENT RISK; REDUCES RISK AB Background and aims: Dietary factors play an important role in promoting nonalcoholic fatty liver disease (NAFLD)-related hepatocellular carcinoma (HCC) development through regulation of metabolism and inflammation. However, so far there was no evidence regarding how dietary factors may influence different disease outcomes in the NAFLD to HCC progression. Our study aimed to comprehensively evaluate the role of dietary factors on the risk of progression from NAFLD to HCC. Methods: A comprehensive literature research was conducted in PubMed, Web of Science and Embase databases to identify case-control and cohort studies published up to March 15, 2022 in English. We included studies investigating associations of food and beverage items (excluding alcohol), food groups, dietary patterns, and dietary habits with incidence risk of four main chronic liver diseases involved in the NAFLD-to-HCC progression (i.e., NAFLD, liver fibrosis, liver cirrhosis, and HCC). Three researchers inde-pendently performed the literature search, selected eligible articles, performed data abstraction and evaluated study quality. After evaluating adequacy and credibility of the associations reported for each dietary factor and each liver disease outcome, we summarized and evaluated the consistency of asso-ciations based on a priori determined criteria considering study design and the proportion of significant associations. Results: There were 109 studies included in this review (47 on NAFLD, 1 on liver fibrosis, 6 on liver cirrhosis, and 55 on HCC). Consistent evidence suggested that higher dietary inflammatory potential was associated with increased risk of both NAFLD and HCC whereas Mediterranean diet was associated with lower risk of both diseases. Additionally, greater conformity to the Healthy Eating Index, Dietary Approaches to Stop Hypertension score, and Mediterranean Diet Score, and dietary patterns with high dietary antioxidant capacity reduced NAFLD risk. Some specific foods including soft drinks and red and/or processed meat were associated with increased NAFLD risk while total vegetables and spinach were associated with reduced NAFLD risk. Coffee and white meat consumption were inversely related to HCC risk. Conclusions: Dietary patterns or individual foods representing a more anti-inflammatory potential were associated with reduced risk of both NAFLD and HCC, which implied diet-induced inflammation may impact NAFLD progression towards HCC. (c) 2022 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved. C1 [Zheng, Jiali; Dong, Jingwen; Chen, Huiyi; Li, Xiaoguang; Wang, Hui] Shanghai Jiao Tong Univ, Sch Publ Hlth, Sch Med, 227 South Chongqing Rd,Rm 415, Shanghai, Peoples R China. [Zhao, Longgang; Steck, Susan E.] Univ South Carolina, Dept Epidemiol & Biostat, Arnold Sch Publ Hlth, Columbia, SC 29208 USA. [Li, Donghui] Univ Texas MD Anderson Canc Ctr, Dept Gastrointestinal Med Oncol, Houston, TX 77030 USA. [Zhang, Xuehong] Brigham & Womens Hosp, Dept Med, Channing Div Network Med, 75 Francis St, Boston, MA 02115 USA. [Zhang, Xuehong] Harvard Med Sch, Boston, MA 02115 USA. [Hassan, Manal M.] Univ Texas MD Anderson Canc Ctr, Dept Epidemiol, Houston, TX 77030 USA. [Xiang, Yong-Bing] Shanghai Jiao Tong Univ, Sch Med, State Key Lab Oncogene & Related Genes, 25 Lane 2200,Xie Tu Rd, Shanghai, Peoples R China. [Xiang, Yong-Bing] Shanghai Jiao Tong Univ, Sch Med, Dept Epidemiol, Renji Hosp,Shanghai Canc Inst, 25 Lane 2200,Xie Tu Rd, Shanghai, Peoples R China. C3 Shanghai Jiao Tong University; University of South Carolina System; University of South Carolina Columbia; University of Texas System; UTMD Anderson Cancer Center; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard University; Harvard Medical School; University of Texas System; UTMD Anderson Cancer Center; Shanghai Jiao Tong University; Shanghai Jiao Tong University RP Li, XG; Wang, H (通讯作者)，Shanghai Jiao Tong Univ, Sch Publ Hlth, Sch Med, 227 South Chongqing Rd,Rm 415, Shanghai, Peoples R China.; Xiang, YB (通讯作者)，Shanghai Jiao Tong Univ, Sch Med, State Key Lab Oncogene & Related Genes, 25 Lane 2200,Xie Tu Rd, Shanghai, Peoples R China.; Xiang, YB (通讯作者)，Shanghai Jiao Tong Univ, Sch Med, Dept Epidemiol, Renji Hosp,Shanghai Canc Inst, 25 Lane 2200,Xie Tu Rd, Shanghai, Peoples R China. EM lixg@shsmu.edu.cn; ybxiang@shsci.org; huiwang@shsmu.edu.cn RI Zheng, Jiali/I-5084-2019; Zhao, Longgang/ABB-9175-2021; Steck, Susan/G-5736-2013; Zhang, Xuehong/E-6219-2012; Li, Xiaoguang/MXJ-7448-2025 OI Zheng, Jiali/0000-0003-1434-2856; Xiang, Yong-Bing/0000-0002-3840-9915; Steck, Susan/0000-0002-3201-9537; FU National Natural Science Foundation of China [82103809, 81630086, GWV-10.1-XK15]; Shanghai Science and Technology Commission [Shanghai Pujiang Program] [20PJ1409600]; National Key Project of Research and Development Program of China [2021YFC2500404]; Innovative research team of high-level local universities in Shanghai; Shanghai Public Health System Con- struction Three -Year Action Plan; [82030099] FX This work was supported by National Natural Science Founda- tion of China [82103809] and Shanghai Science and Technology Commission [Shanghai Pujiang Program 20PJ1409600] , National Key Project of Research and Development Program of China [2021YFC2500404] , National Natural Science Foundation of China [82030099 and 81630086] , Shanghai Public Health System Con- struction Three -Year Action Plan GWV-10.1-XK15 and Innovative research team of high-level local universities in Shanghai. 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PD OCT PY 2022 VL 41 IS 10 BP 2295 EP 2307 DI 10.1016/j.clnu.2022.08.018 EA SEP 2022 PG 13 WC Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Nutrition & Dietetics GA 4R5CH UT WOS:000856781500003 PM 36096063 DA 2026-02-02 ER PT J AU Chiarioni, G Popa, SL Dalbeni, A Senore, C Leucuta, DC Baroni, L Fantin, A AF Chiarioni, Giuseppe Popa, Stefan-Lucian Dalbeni, Andrea Senore, Carlo Leucuta, Daniel Corneliu Baroni, Luciana Fantin, Alberto TI Vegan Diet Advice Might Benefit Liver Enzymes in Nonalcoholic Fatty Liver Disease: an Open Observational Pilot Study SO JOURNAL OF GASTROINTESTINAL AND LIVER DISEASES LA English DT Article DE non-alcoholic fatty liver disease; NAFLD; vegan diet; liver enzymes; transaminase; physical activity; liver disease; body weight; body mass index; NASH; lifestyle intervention ID MEDITERRANEAN DIET; WEIGHT-LOSS; MANAGEMENT; NAFLD; GUIDELINES; ADHERENCE; INDIVIDUALS; SEVERITY; TRIAL; RISK AB Background & Aims: The Western diet is rich in saturated fats, refined sugars and meat consistent with a high-energy load and secondary risk of increased metabolic diseases including nonalcoholic fatty liver disease (NAFLD). However, no data are available on potential benefit of vegan diets in NAFLD and/or nonalcoholic steatohepatitis (NASH). We aimed to study prospectively the effect of a vegan diet, excluding all animal products on liver chemistry in a group of consecutive NAFLD patients. Methods: This was a prospective, pilot study run on 40 consecutive patients affected by NAFLD. Eight subjects refused to join the study for poor diet palatability, leaving 32 patients (19 males, mean age 50 years), with abnormal measures of liver function who agreed to adhere to a vegan diet for six months. The caloric intake was tailored by the dietitian to obtain a weight loss >= 5% of body weight in overweight patients [body-mass index (BMI) >= 25] and ranged from 1500 Kcal to 1800 Kcal. Patients were contacted monthly by phone to reinforce diet and lifestyle advice and were seen at the gastrointestinal clinic when doubtful about diet advice. Results: At six-month follow-up, 6 subjects did not attend the clinic leaving only 26 patients for data analysis. Initial anthropometric values were mean weight 78 kg (range 52-95), mean body mass index (BMI) 26.8 Kg/m(2) (range 20.3-31.2). Liver function tests showed mean ALT value 99 U/L (SD +/- 45), mean AST value 54 U/L (SD +/- 44), mean GGT value 160 U/L (SD +/- 122), pre-treatment. After six months mean body weight was 73 Kg (range 52-87), mean BMI was 25.2 Kg/m(2) (range 20.3-29.7) (p<0.001 compared to baseline for both parameters). Liver enzymes improved to a mean of ALT value 36 U/L (SD +/- 21), AST value 27 U/L (SD +/- 10) and GGT value 55 U/L (SD +/- 57), respectively (p<0.001 compared to baseline for all enzymes). Normalization of liver function tests as a whole was observed in 20/26 patients (76.9%). A loss of >= 5% of body weight was observed in 12 patients (46.1%), but it did not correlate with the normalization of liver function tests (p=0.5). Conclusions: Our data provide preliminary evidence of improved liver enzymes in NAFLD patients with a strict vegan diet and although our study sample is limited, decreased body weight did not seem critical to the outcome. C1 [Chiarioni, Giuseppe] Univ Verona, Div Gastroenterol, AOUI Verona, Verona, Italy. [Chiarioni, Giuseppe] Univ North Carolina Chapel Hill, Div Gastroenterol & Hepatol, Chapel Hill, NC USA. [Popa, Stefan-Lucian] Med Dept 2, Iuliu Hatieganu Univ Med & Pharm, Cluj Napoca, Romania. [Dalbeni, Andrea] AOUI Verona, Sect Internal Med & Liver Unit, Dept Med, Verona, Italy. [Senore, Carlo] AOU Citta Salute & Sci, SSD Epidemiol & Screening CPO, Turin, Italy. [Leucuta, Daniel Corneliu] Iuliu Hatieganu Univ Med & Pharm, Dept Med Informat & Biostat, Cluj Napoca, Romania. [Baroni, Luciana] Local Hlth Unit 2 Marca Trevigiana, Treviso, Italy. [Fantin, Alberto] Ist Oncol Veneto IOV IRCCS, Gastroenterol Unit, Padua, Italy. C3 University of Verona; Azienda Ospedaliera Universitaria Integrata Verona; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; Iuliu Hatieganu University of Medicine & Pharmacy; University of Verona; Azienda Ospedaliera Universitaria Integrata Verona; A.O.U. Citta della Salute e della Scienza di Torino; Iuliu Hatieganu University of Medicine & Pharmacy; IRCCS Istituto Oncologico Veneto (IOV) RP Chiarioni, G (通讯作者)，Gastroenterol B Osped Policlin GB Rossi, Piazzale Scuro 10, I-37134 Verona, Italy. EM chiarioni@alice.it RI Leucuța, Daniel/E-3625-2014; Chiarioni, Giuseppe/C-1876-2016; Stefan-Lucian, Popa/D-7056-2019; Dalbeni, Andrea/AAB-7784-2019; baroni, luciana/AAG-5281-2020 OI Leucuța, Daniel/0000-0003-4218-8622; baroni, luciana/0000-0001-5263-6084 CR Aller R, 2015, NUTR HOSP, V32, P2518 Amer Diabet Assoc, 2013, DIABETES CARE, V36, pS67, DOI 10.2337/dc13-S067 Baratta F, 2017, AM J GASTROENTEROL, V112, P1832, DOI 10.1038/ajg.2017.371 Barkas F, 2015, CURR MED RES OPIN, V31, P221, DOI 10.1185/03007995.2014.982751 Barnard ND, 2005, AM J MED, V118, P991, DOI 10.1016/j.amjmed.2005.03.039 Barnard ND, 2006, DIABETES CARE, V29, P1777, DOI 10.2337/dc06-0606 Byrne CD, 2015, J HEPATOL, V62, pS47, DOI 10.1016/j.jhep.2014.12.012 Chalasani N, 2012, HEPATOLOGY, V55, P2005, DOI 10.1002/hep.25762 Chan R, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0139310 Cobbina E, 2017, DRUG METAB REV, V49, P197, DOI 10.1080/03602532.2017.1293683 Eslam M, 2018, J HEPATOL, V68, P268, DOI 10.1016/j.jhep.2017.09.003 European Association for the Study of the Liver (EASL), 2016, J Hepatol, V64, P1388, DOI 10.1016/j.jhep.2015.11.004 Friedman SL, 2018, NAT MED, V24, P908, DOI 10.1038/s41591-018-0104-9 Gelli C, 2017, WORLD J GASTROENTERO, V23, P3150, DOI 10.3748/wjg.v23.i17.3150 Hardy T, 2015, CURR OPIN GASTROEN, V31, P175, DOI 10.1097/MOG.0000000000000175 Harris R, 2020, ALIMENT PHARM THER, V51, P1199, DOI 10.1111/apt.15714 Kontogianni MD, 2014, CLIN NUTR, V33, P678, DOI 10.1016/j.clnu.2013.08.014 Leoni S, 2018, WORLD J GASTROENTERO, V24, P3361, DOI 10.3748/wjg.v24.i30.3361 Loguercio C, 2011, WORLD J GASTROENTERO, V17, P2288, DOI 10.3748/wjg.v17.i18.2288 Marchisello S, 2019, INT J MOL SCI, V20, DOI 10.3390/ijms20081948 Melina V, 2016, J ACAD NUTR DIET, V116, P1970, DOI 10.1016/j.jand.2016.09.025 Mitra S, 2020, TRANSL GASTROENT HEP, V5, DOI 10.21037/tgh.2019.09.08 Moore WJ, 2015, EAT BEHAV, V19, P33, DOI 10.1016/j.eatbeh.2015.06.011 Musso G, 2011, ANN MED, V43, P617, DOI 10.3109/07853890.2010.518623 Najjar RS, 2019, NUTRIENTS, V11, DOI 10.3390/nu11112712 Rinella ME, 2016, NAT REV GASTRO HEPAT, V13, P196, DOI 10.1038/nrgastro.2016.3 Ryan MC, 2013, J HEPATOL, V59, P138, DOI 10.1016/j.jhep.2013.02.012 Sanyal AJ, 2019, NAT REV GASTRO HEPAT, V16, P377, DOI 10.1038/s41575-019-0144-8 Sheka AC, 2020, JAMA-J AM MED ASSOC, V323, P1175, DOI 10.1001/jama.2020.2298 Shen F, 2017, HEPATOB PANCREAT DIS, V16, P375, DOI 10.1016/S1499-3872(17)60019-5 Targher G, 2010, NEW ENGL J MED, V363, P1341, DOI 10.1056/NEJMra0912063 Toplak H, 2016, DIABETOLOGIA, V59, P1148, DOI 10.1007/s00125-016-3941-4 Trovato FM, 2015, CLIN NUTR, V34, P86, DOI 10.1016/j.clnu.2014.01.018 Turner-McGrievy GM, 2015, NUTRITION, V31, P350, DOI 10.1016/j.nut.2014.09.002 Tuso Philip J, 2013, Perm J, V17, P61, DOI 10.7812/TPP/12-085 Wood Natalie J, 2010, Nat Rev Gastroenterol Hepatol, V7, P357, DOI 10.1038/nrgastro.2010.95 Worm N, 2020, NUTRIENTS, V12, DOI 10.3390/nu12051316 Wright L, 2015, VEGAN STUDIES PROJECT: FOOD, ANIMALS, AND GENDER IN THE AGE OF TERROR, P1 Younossi Z, 2018, NAT REV GASTRO HEPAT, V15, P11, DOI 10.1038/nrgastro.2017.109 Zhang C, 2020, MOL SYST BIOL, V16, DOI 10.15252/msb.209495 Zhou MT, 2020, BIOMED RES INT, V2020, DOI 10.1155/2020/5462063 NR 41 TC 11 Z9 11 U1 0 U2 1 PU MEDICAL UNIV PRESS PI CLUJ-NAPOCA PA 3RD MEDICAL CLINIC, STR CROITORILOR NO 19-21, CLUJ-NAPOCA, 400162, ROMANIA SN 1841-8724 EI 1842-1121 J9 J GASTROINTEST LIVER JI J. Gastrointest. Liver Dis. PD MAR PY 2021 VL 30 IS 1 BP 81 EP 87 DI 10.15403/jgld-3064 PG 7 WC Gastroenterology & Hepatology WE Science Citation Index Expanded (SCI-EXPANDED) SC Gastroenterology & Hepatology GA QW9ZF UT WOS:000629007900016 PM 33548123 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Torres, MCP Bodini, G Furnari, M Marabotto, E Zentilin, P Giannini, EG AF Plaz Torres, Maria Corina Bodini, Giorgia Furnari, Manuele Marabotto, Elisa Zentilin, Patrizia Giannini, Edoardo G. TI Nuts and Non-Alcoholic Fatty Liver Disease: Are Nuts Safe for Patients with Fatty Liver Disease? SO NUTRIENTS LA English DT Review DE steatosis; steatohepatitis; liver disease; hepatocellular carcinoma; aflatoxin; peanuts ID AFLATOXIN B-1 HEPATOTOXICITY; CAUSE-SPECIFIC MORTALITY; MEDITERRANEAN DIET; METABOLIC SYNDROME; CONSUMPTION; RISK; EXPOSURE; METAANALYSIS; ALMONDS; FOOD AB Diet and lifestyle interventions are the recommended treatment for patients with non-alcoholic fatty liver disease (NAFLD), with the aim of achieving a 7-10% weight loss. Several dietary patterns have been suggested for this purpose, however, to date, the best one is represented by the Mediterranean diet (MD) as it is rich in macro- and micro- nutrients known for their effectiveness in health-promotion and cardio-vascular disease prevention. Moreover, MD is characterized by the inclusion of nuts. These foods have shown potential benefits in health-promotion as they are rich in fibers, which have lipid-lowering effects, rich in mono- and poly-unsaturated fatty acids, which help reduce insulin-resistance and serum cholesterol, and contain anti-oxidants which reduce oxidative stress and inflammation. Additionally, nuts are associated with a better control, or reduction, of Body Mass Index (BMI). All these effects are useful targets to achieve in NAFLD, so that nuts have been proposed as a suitable dietary treatment supplement for weight and metabolic control in these patients. In recent years, health authorities raised an alert on nuts consumption as these may be at high risk of aflatoxin (AF) contamination, for which controls and legislations are different among countries. AF is a well-known cancerogenic agent and a recognized risk factor for hepatocellular carcinoma. Patients with NAFLD have an overall, inherent sevenfold increased risk of developing hepatocellular carcinoma as compared with the general population. In this context, one could argue that recommending the inclusion of nuts in the diet of NAFLD patients has to be balanced with the risk of potential chronic exposure to AF, and every effort should be pursued to assure the safety of these nutrients. In this review, we aim to summarize the benefits of nuts consumption, the evidence for AF contamination of nuts and the consequent potential risks in patients with NAFLD. C1 [Plaz Torres, Maria Corina; Bodini, Giorgia; Furnari, Manuele; Marabotto, Elisa; Zentilin, Patrizia; Giannini, Edoardo G.] Univ Genoa, Dept Internal Med, Gastroenterol Unit, IRCCS Osped Policlin San Martino, I-16132 Genoa, Italy. C3 University of Genoa; IRCCS AOU San Martino IST RP Giannini, EG (通讯作者)，Univ Genoa, Dept Internal Med, Gastroenterol Unit, IRCCS Osped Policlin San Martino, I-16132 Genoa, Italy. 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AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND EI 2072-6643 J9 NUTRIENTS JI Nutrients PD NOV PY 2020 VL 12 IS 11 AR 3363 DI 10.3390/nu12113363 PG 15 WC Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Nutrition & Dietetics GA OX7RW UT WOS:000593758300001 PM 33139607 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Marin-Alejandre, BA Cantero, I Perez-Diaz-del-Campo, N Monreal, JI Elorz, M Herrero, JI Benito-Boillos, A Quiroga, J Martinez-Echeverria, A Uriz-Otano, JI Huarte-Muniesa, MP Tur, JA Martinez, JA Abete, I Zulet, MA AF Marin-Alejandre, Bertha A. Cantero, Irene Perez-Diaz-del-Campo, Nuria Monreal, Jose I. Elorz, Mariana Herrero, Jose I. Benito-Boillos, Alberto Quiroga, Jorge Martinez-Echeverria, Ana Uriz-Otano, Juan I. Huarte-Muniesa, Maria P. Tur, Josep A. Martinez, Jose A. Abete, Itziar Zulet, Maria A. TI Effects of two personalized dietary strategies during a 2-year intervention in subjects with nonalcoholic fatty liver disease: A randomized trial SO LIVER INTERNATIONAL LA English DT Article DE AHA; fatty liver; FLiO; Mediterranean diet; NAFLD; obesity ID PHYSICAL-ACTIVITY QUESTIONNAIRE; LIFE-STYLE INTERVENTIONS; ANTIOXIDANT CAPACITY; METABOLIC SYNDROME; HEPATIC STEATOSIS; WEIGHT-LOSS; MANAGEMENT; INDEX; GUIDELINES; PLASMA AB Background and objectives Nonalcoholic fatty liver disease (NAFLD) management is focused on lifestyle modifications, but long-term maintenance is a challenge for many individuals. This study aimed to evaluate the long-term effects of two personalized energy-restricted dietary strategies on weight loss, metabolic and hepatic outcomes in overweight/obese subjects with NAFLD. Methods Ninety-eight subjects from the Fatty Liver in Obesity (FLiO) study (NCT03183193) were randomly assigned to the American Heart Association (AHA) or the FLiO dietary group in a 2-year controlled trial. Anthropometry, body composition (DXA), biochemical parameters and hepatic status (ultrasonography, Magnetic Resonance Imaging, and elastography) were assessed at baseline, 6, 12 and 24 months. Results Both the AHA and FLiO diets significantly reduced body weight at 6 (-9.7% vs -10.1%), 12 (-6.7% vs -9.6%), and 24 months (-4.8% vs -7.6%) with significant improvements in body composition, biochemical and liver determinations throughout the intervention. At the end of the follow-up, the FLiO group showed a greater decrease in ALT, liver stiffness and Fatty Liver Index, among others, compared to AHA group, although these differences were attenuated when the analyses were adjusted by weight loss percentage. The FLiO group also showed a greater increase in adiponectin compared to AHA group. Conclusions The AHA and FLiO diets were able to improve body weight and body composition, as well as metabolic and hepatic status of participants with overweight/obesity and NAFLD within a 2-year follow-up. These findings show that both strategies are suitable alternatives for NAFLD management. However, the FLiO strategy may provide more persistent benefits in metabolic and hepatic parameters. C1 [Marin-Alejandre, Bertha A.; Cantero, Irene; Perez-Diaz-del-Campo, Nuria; Martinez, Jose A.; Abete, Itziar; Zulet, Maria A.] Univ Navarra, Fac Pharm & Nutr, Dept Nutr Food Sci & Physiol, Irunlarrea 1, Pamplona 31008, Spain. [Marin-Alejandre, Bertha A.; Cantero, Irene; Perez-Diaz-del-Campo, Nuria; Martinez, Jose A.; Abete, Itziar; Zulet, Maria A.] Univ Navarra, Fac Pharm & Nutr, Ctr Nutr Res, Irunlarrea 1, Pamplona 31008, Spain. [Monreal, Jose I.; Elorz, Mariana; Herrero, Jose I.; Benito-Boillos, Alberto; Quiroga, Jorge; Martinez-Echeverria, Ana; Uriz-Otano, Juan I.; Huarte-Muniesa, Maria P.; Martinez, Jose A.; Abete, Itziar; Zulet, Maria A.] Navarra Inst Hlth Res IdiSNA, Pamplona, Spain. [Monreal, Jose I.] Clin Univ Navarra, Clin Chem Dept, Pamplona, Spain. [Elorz, Mariana; Benito-Boillos, Alberto] Clin Univ Navarra, Dept Radiol, Pamplona, Spain. [Herrero, Jose I.] Clin Univ Navarra, Liver Unit, Pamplona, Spain. [Herrero, Jose I.; Quiroga, Jorge] Ctr Invest Biomed Red Enfermedades Hepat & Digest, Madrid, Spain. [Quiroga, Jorge] Clin Univ Navarra, Dept Internal Med, Pamplona, Spain. [Martinez-Echeverria, Ana; Uriz-Otano, Juan I.; Huarte-Muniesa, Maria P.] Complejo Hosp Navarra, Dept Gastroenterol, Pamplona, Spain. [Tur, Josep A.] Univ Balearic Isl, Res Grp Community Nutr & Oxidat Stress, Palma De Mallorca, Spain. [Tur, Josep A.] Balear Isl Inst Hlth Res IDISBA, Palma De Mallorca, Spain. [Martinez, Jose A.; Abete, Itziar; Zulet, Maria A.] Inst Salud Carlos III, Biomed Res Ctr Network Physiopathol Obes & Nutr C, Madrid, Spain. C3 University of Navarra; University of Navarra; University of Navarra; University of Navarra; University of Navarra; University of Navarra; CIBER - Centro de Investigacion Biomedica en Red; CIBEREHD; University of Navarra; Servicio Navarro de Salud - Osasunbidea; Universitat de les Illes Balears; Instituto de Salud Carlos III RP Zulet, MA (通讯作者)，Univ Navarra, Fac Pharm & Nutr, Dept Nutr Food Sci & Physiol, Irunlarrea 1, Pamplona 31008, Spain.; Zulet, MA (通讯作者)，Univ Navarra, Fac Pharm & Nutr, Ctr Nutr Res, Irunlarrea 1, Pamplona 31008, Spain. EM mazulet@unav.es RI ; Benito, Alberto/AAD-4201-2020; Pérez Díaz del Campo, Nuria/HGC-4070-2022; Carlón, Mariana/ABD-5128-2021; Tur, Josep/AAE-5748-2020 OI Quiroga, Jorge/0000-0003-2789-6735; Benito, Alberto/0000-0002-1527-0092; Pérez Díaz del Campo, Nuria/0000-0003-0479-8825; Elorz Carlón, Mariana/0000-0002-1580-3629; Marín Alejane, Bertha Araceli/0000-0003-0741-8197; FU Health Department of the Government of Navarra [61/2015]; CIBERobn (Physiopathology of Obesity and Nutrition) [CB12/03/3002]; Fundacio La Marato de TV3 [201630.10]; Consejo Nacional de Ciencia y Tecnologia (CONACYT) y el Estado de Michoacan [440104/2016] FX This research was funded by the Health Department of the Government of Navarra (61/2015), CIBERobn (Physiopathology of Obesity and Nutrition) (CB12/03/3002), Fundacio La Marato de TV3 (201630.10). BAM-A. was supported by predoctoral research grant from Consejo Nacional de Ciencia y Tecnologia (CONACYT) y el Estado de Michoacan (440104/2016). 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PD JUL PY 2021 VL 41 IS 7 BP 1532 EP 1544 DI 10.1111/liv.14818 EA MAR 2021 PG 13 WC Gastroenterology & Hepatology WE Science Citation Index Expanded (SCI-EXPANDED) SC Gastroenterology & Hepatology GA ST3FO UT WOS:000623508000001 PM 33550706 DA 2026-02-02 ER PT J AU Scavo, MP Depalo, N Rizzi, F Carrieri, L Serino, G Franco, I Bonfiglio, C Pesole, PL Cozzolongo, R Gianuzzi, V Curri, ML Osella, AR Giannelli, G AF Scavo, Maria Principia Depalo, Nicoletta Rizzi, Federica Carrieri, Livianna Serino, Grazia Franco, Isabella Bonfiglio, Caterina Pesole, Pasqua Letizia Cozzolongo, Raffaele Gianuzzi, Vito Curri, Maria Lucia Osella, Alberto Ruben Giannelli, Gianluigi TI Exosomal FZD-7 Expression Is Modulated by Different Lifestyle Interventions in Patients with NAFLD SO NUTRIENTS LA English DT Article DE NAFLD; plasma-derived exosomes; Frizzled 7; low glycemic index Mediterranean diet; physical activity ID FATTY LIVER-DISEASE; CONTROLLED ATTENUATION PARAMETER; HEPATOCELLULAR-CARCINOMA; OVEREXPRESSION; EPIDEMIOLOGY; PATHWAY; INJURY; TUMORS; DIET AB Non-alcoholic fatty liver disease (NAFLD) is a multifactorial condition characterized from hypertriglyceridemia and hepatic fat accumulation, in the absence of alcohol intake. NAFLD starts as steatosis (NAFL), and the continued injury relative to the toxic fat induces inflammation, steatohepatitis (NASH), and HCC. One of the factors determining liver degeneration during the evolution of NAFLD is a modification of Wnt/Frizzled (FZD) signaling. In particular, an inhibition of Wnt signaling and an overexpression of a specific FZD receptor protein, namely, the FZD7, have been observed in NAFLD. Actually, the prognosis and the follow-up of NAFLD is not easy, and the liver biopsy is the gold standard for an accurate detection of liver fibrosis. In this study, the modulation of the FZD7 expression levels in plasma-derived exosomes of NAFLD-affected patients, before and after specific lifestyle interventions, were experimentally evaluated by Western blotting analysis. The experimental data were analyzed by an accurate statistical study that indicated, in the exosomes derived from plasma of NAFLD patients with moderate or severe steatosis, an average expression level of FZD7 that was significantly higher than healthy subjects at baseline; conversely, the values were normalized after 90 days of specific lifestyle interventions. The overall results suggested that the FZD7 delivered by exosomes represents a good candidate as a new and effective biomarker for diagnosis and prognosis of NAFLD. C1 [Scavo, Maria Principia; Carrieri, Livianna] S De Bellis Res Hosp, Natl Inst Gastroenterol, Lab Personalized Med, Via Turi 27, I-70013 Bari, Italy. [Depalo, Nicoletta; Rizzi, Federica; Curri, Maria Lucia] Italian Natl Res Council IPCF CNR SS Bari, Inst Chem Phys Proc, Via Orabona 4, I-70125 Bari, Italy. [Rizzi, Federica; Curri, Maria Lucia] Univ Bari Aldo Moro, Dipartimento Chim, Via Orabona 4, I-70125 Bari, Italy. [Serino, Grazia] S de Bellis Res Hosp, Natl Inst Gastroenterol, Mol Med, Via Turi 27, I-70013 Bari, Italy. [Franco, Isabella; Bonfiglio, Caterina; Osella, Alberto Ruben] S de Bellis Res Hosp, Natl Inst Gastroenterol, Lab Epidemiol & Biostat, Via Turi 27, I-70013 Bari, Italy. [Pesole, Pasqua Letizia] S de Bellis Res Hosp, Natl Inst Gastroenterol, Dept Pathol, Via Turi 27, I-70013 Bari, Italy. [Cozzolongo, Raffaele; Gianuzzi, Vito] S de Bellis Res Hosp, Natl Inst Gastroenterol, Dept Gastroenterol, Via Turi 27, I-70013 Bari, Italy. [Giannelli, Gianluigi] S de Bellis Res Hosp, Natl Inst Gastroenterol, Sci Direct, I-70013 Bari, Italy. C3 Universita degli Studi di Bari Aldo Moro RP Scavo, MP (通讯作者)，S De Bellis Res Hosp, Natl Inst Gastroenterol, Lab Personalized Med, Via Turi 27, I-70013 Bari, Italy.; Depalo, N (通讯作者)，Italian Natl Res Council IPCF CNR SS Bari, Inst Chem Phys Proc, Via Orabona 4, I-70125 Bari, Italy. EM maria.scavo@irccsdebellis.it; n.depalo@ba.ipcf.cnr.it; federica.rizzi@uniba.it; livianna.carrieri@irccsdebellis.it; grazia.serino@irccsdebellis.it; isabella.franco@irccsdebellis.it; catia.bonfiglio@irccsdebellis.it; letizia.pesole@irccsdebellis.it; raffaele.cozzolongo@irccsdebellis.it; vito.giannuzzi@irccsdebellis.it; marialucia.curri@uniba.it; arosella@irccsdebellis.it; gianluigi.giannelli@irccsdebellis.it RI cozzolongo, raffaele/ABH-5696-2020; giannelli, gianluigi/A-8169-2012; Rizzi, Federica/IWU-5273-2023; Depalo, Nicoletta/AAD-9489-2020; Serino, Grazia/K-2255-2018; Carrieri, Livianna/JQI-6725-2023; scavo, maria principia/AAR-6713-2020; CURRI, MARIALUCIA/C-5360-2009; Osella, Alberto/M-6888-2014 OI Rizzi, Federica/0000-0001-8891-4218; Depalo, Nicoletta/0000-0002-2107-2762; FRANCO, ISABELLA/0000-0002-3697-0127; Serino, Grazia/0000-0002-2971-0802; Carrieri, Livianna/0000-0001-6769-9520; scavo, maria principia/0000-0002-0812-4441; Bonfiglio, Caterina/0000-0002-8650-348X; pesole, pasqua letizia/0000-0003-4675-2075; CURRI, MARIALUCIA/0000-0002-0261-8379; Osella, Alberto/0000-0003-4232-8760 FU Ministero della salute, Ricerca corrente 2019 FX This research was funded by Ministero della salute, Ricerca corrente 2019. 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TI Childhood Fructoholism and Fructoholic Liver Disease SO HEPATOLOGY COMMUNICATIONS LA English DT Review ID DE-NOVO LIPOGENESIS; FATTY LIVER; NONALCOHOLIC STEATOHEPATITIS; FRUCTOSE CONSUMPTION; NATURAL-HISTORY; SUGAR INTAKE; PEDIATRIC GASTROENTEROLOGY; MEDITERRANEAN DIET; PRACTICE GUIDELINE; METABOLIC SYNDROME AB Nonalcoholic fatty liver disease (NAFLD) is an emerging entity, becoming the most prevalent pediatric chronic liver disease. Its broad spectrum of histological findings, comorbidities, and complications, including cirrhosis and liver failure, can occur in childhood, emphasizing the severity of pediatric NAFLD. Current lifestyle and diet modifications have been linked to the increasing prevalence of NAFLD, including the rise of fructose consumption, a monosaccharide present in foods that contain added sugar, such as sugar-sweetened beverages. Excessive fructose consumption is believed to cause addiction like alcohol and other drugs. As such, the new term fructoholism refers to the consumption of a substance (fructose) that can cause psychological and physical damage and become a major public health concern, highlighting the seriousness of the excessive consumption of fructose in the pediatric age. Hepatic fructose metabolization leads to hepatic steatosis and progression to fibrosis through mechanisms comparable to alcoholic liver disease, hence the term fructoholic liver disease. Conclusion: The importance of implementing reliable global strategies, such as education campaigns to promote healthy diet, increasing taxes on foods that contain added sugars, subsidies to promote accessibility to fruit and vegetables, and strict food industry regulation to reduce sugar intake in children and adolescents, cannot be overemphasized. C1 [Ribeiro, Andreia; Igual-Perez, Maria-Jose; Sokal, Etienne M.] Catholic Univ Louvain, Clin Univ St Luc, Serv Gastroenterol & Hepatol Pediat, Brussels, Belgium. 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Commun. PD JAN PY 2019 VL 3 IS 1 BP 44 EP 51 DI 10.1002/hep4.1291 PG 8 WC Gastroenterology & Hepatology WE Science Citation Index Expanded (SCI-EXPANDED) SC Gastroenterology & Hepatology GA HF9SX UT WOS:000454583900005 PM 30619993 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Sarwar, R Pierce, N Koppe, S AF Sarwar, Raiya Pierce, Nicholas Koppe, Sean TI Obesity and nonalcoholic fatty liver disease: current perspectives SO DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY LA English DT Review DE nonalcoholic fatty liver disease; nonalcoholic steatohepatitis; pharmacotherapy; clinical trials; antifibrotics ID CORONARY-HEART-DISEASE; HEPATIC STEATOSIS; VITAMIN-E; MEDITERRANEAN DIET; CARDIOVASCULAR OUTCOMES; DOUBLE-BLIND; FIBROSIS; STEATOHEPATITIS; PLACEBO; MULTICENTER AB Nonalcoholic fatty liver disease (NAFLD) is rapidly becoming the most common cause of chronic liver disease due to an increase in the prevalence of obesity. The development of NASH leads to an increase in morbidity and mortality. While the first line of treatment is lifestyle modifications, including dietary changes and increased physical activity, there are no approved pharmacological treatment agents for NAFLD and NASH currently. Due to its complex pathophysiology, different pathways are under investigation for drug development with the focus on metabolic pathways, inflammation, and slowing or reversing fibrosis. There are several agents advancing in clinical trials, and promising results have been seen with drugs that affect hepatic steatosis, inflammation, and fibrosis. This review will provide an overview on NAFLD and some of the mechanisms of disease that are being targeted with pharmacologic agents. C1 [Sarwar, Raiya] Univ Illinois, Dept Internal Med, Champaign, IL USA. [Pierce, Nicholas] Univ Med & Hlth Sci, New York, NY USA. [Koppe, Sean] Univ Illinois, Dept Med, Div Gastroenterol & Hepatol, Chicago, IL USA. C3 University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Chicago; University of Illinois Chicago Hospital RP Koppe, S (通讯作者)，Univ Illinois, Div Gastroenterol & Hepatol, 840 S Wood St,Suite 1020S, Chicago, IL 60612 USA. EM skoppe1@uic.edu RI Koppe, Sean/AAZ-4963-2021; sarwar, raiya/OMN-4939-2025 OI Koppe, Sean/0000-0002-0581-1115; Sarwar, Raiya/0000-0001-7056-8644; CR Abner Erin L, 2011, Curr Aging Sci, V4, P158 Ali AH, 2015, ANN TRANSL MED, V3, DOI 10.3978/j.issn.2305-5839.2014.12.06 Angulo P, 2015, GASTROENTEROLOGY, V149, P389, DOI 10.1053/j.gastro.2015.04.043 [Anonymous], SAF EFF SEL AD COMP [Anonymous], SAF EFF SEL AD NON S Armstrong MJ, 2016, LANCET, V387, P679, DOI 10.1016/S0140-6736(15)00803-X Athyros VG, 2010, LANCET, V376, P1916, DOI 10.1016/S0140-6736(10)61272-X Cable EE, 2009, HEPATOLOGY, V49, P407, DOI 10.1002/hep.22572 Caldwell S, 2010, J HEPATOL, V53, P719, DOI 10.1016/j.jhep.2010.04.031 Chalasani N, 2018, HEPATOLOGY, V67, P328, DOI [10.1002/hep.29367, 10.1038/s42255-021-00344-4] Clinical Trials.gov, CLIN TRIAL EV EFF SA Clinical Trials.gov, RAND DOUBL BLIND PLA Clinical Trials.gov, EMR CASP INH EV SUBJ Clinical Trials.gov, EMR CASP INH TREATM Colca JR, 2017, HEPATOL COMMUN, V1, P193, DOI 10.1002/hep4.1036 Corey KE, 2014, LIPIDS HEALTH DIS, V13, DOI 10.1186/1476-511X-13-100 Del Ben M, 2017, NUTR METAB CARDIOVAS, V27, P161, DOI 10.1016/j.numecd.2016.09.011 Dulai PS, 2016, J HEPATOL, V65, P1006, DOI 10.1016/j.jhep.2016.06.005 Ekstedt M, 2015, HEPATOLOGY, V61, P1547, DOI 10.1002/hep.27368 Friedman SL, 2018, HEPATOLOGY, V67, P1754, DOI 10.1002/hep.29477 Fuchs M, 2012, J LIPIDS, V2012, DOI 10.1155/2012/934396 Fukunaga T, 2015, J BONE MINER RES, V30, P508, DOI 10.1002/jbmr.2364 Gawrieh S, 2018, CLIN LIVER DIS, V22, P189, DOI 10.1016/j.cld.2017.08.013 George AS, 2009, HEPATOLOGY, V50, P68, DOI 10.1002/hep.22940 Golabi P, 2017, CLIN LIVER DIS, V21, P739, DOI 10.1016/j.cld.2017.06.010 Harrison S, GS2 MGL 3196 SELECTI Harrison SA, 2017, J HEPATOL, V66, pS92, DOI 10.1016/S0168-8278(17)30448-8 Klein EA, 2011, JAMA-J AM MED ASSOC, V306, P1549, DOI 10.1001/jama.2011.1437 Kleiner DE, 2005, HEPATOLOGY, V41, P1313, DOI 10.1002/hep.20701 Konerman MA, 2018, J HEPATOL, V68, P362, DOI 10.1016/j.jhep.2017.10.015 Kontogianni MD, 2014, CLIN NUTR, V33, P678, DOI 10.1016/j.clnu.2013.08.014 Lavine JE, 2011, JAMA-J AM MED ASSOC, V305, P1659, DOI 10.1001/jama.2011.520 Lefebvre E, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0158156 Lewis JH, 2007, HEPATOLOGY, V46, P1453, DOI 10.1002/hep.21848 Li Y, 2013, BIOMED REP, V1, P57, DOI 10.3892/br.2012.18 Loomba R, 2016, GS 4997 INHIBITOR AP Malhi H, 2017, CURR OPIN PHARMACOL, V37, P80, DOI 10.1016/j.coph.2017.09.008 Markova M, 2017, GASTROENTEROLOGY, V152, P571, DOI 10.1053/j.gastro.2016.10.007 Marso SP, 2016, NEW ENGL J MED, V375, P311, DOI [10.1056/NEJMoa1603827, 10.1056/NEJMc1615712] Miller ER, 2005, ANN INTERN MED, V142, P37, DOI 10.7326/0003-4819-142-1-200501040-00110 Miura K, 2012, AM J PHYSIOL-GASTR L, V302, pG1310, DOI 10.1152/ajpgi.00365.2011 Musso G, 2012, DIABETOLOGIA, V55, P885, DOI 10.1007/s00125-011-2446-4 Musso G, 2017, JAMA INTERN MED, V177, P633, DOI 10.1001/jamainternmed.2016.9607 Musso G, 2010, HEPATOLOGY, V52, P79, DOI 10.1002/hep.23623 Neuschwander-Tetri BA, 2017, BMC MED, V15, DOI 10.1186/s12916-017-0806-8 Neuschwander-Tetri BA, 2015, LANCET, V385, P956, DOI 10.1016/S0140-6736(14)61933-4 Onyekwere CA, 2015, NIGER J CLIN PRACT, V18, P703, DOI 10.4103/1119-3077.163288 Park CC, 2017, GASTROENTEROLOGY, V152, P598, DOI 10.1053/j.gastro.2016.10.026 Pavlides M, 2017, LIVER INT, V37, P1065, DOI 10.1111/liv.13284 Poulsen LL, 2012, SEMIN CELL DEV BIOL, V23, P631, DOI 10.1016/j.semcdb.2012.01.003 Ratziu V, 2016, J HEPATOL, V64, pS294, DOI 10.1016/S0168-8278(16)00372-X Ratziu V, 2016, GASTROENTEROLOGY, V150, P1147, DOI 10.1053/j.gastro.2016.01.038 Risérus U, 2008, DIABETES, V57, P332, DOI 10.2337/db07-1318 Ryan MC, 2013, J HEPATOL, V59, P138, DOI 10.1016/j.jhep.2013.02.012 Safadi R, 2014, CLIN GASTROENTEROL H, V12, P2085, DOI 10.1016/j.cgh.2014.04.038 Sanyal A, 2017, J HEPATOL, V66, pS89, DOI 10.1016/S0168-8278(17)30443-9 Sanyal AJ, 2010, NEW ENGL J MED, V362, P1675, DOI 10.1056/NEJMoa0907929 Sasso M, 2016, ULTRASOUND MED BIOL, V42, P92, DOI 10.1016/j.ultrasmedbio.2015.08.008 Sinha RA, 2018, NAT REV ENDOCRINOL, V14, P259, DOI 10.1038/nrendo.2018.10 Sofi F, 2013, BIOFACTORS, V39, P335, DOI 10.1002/biof.1096 Sosale A, 2015, DIABET METAB SYND OB, V8, P189, DOI 10.2147/DMSO.S49592 Tikkanen MJ, 2013, INT J CARDIOL, V168, P3846, DOI 10.1016/j.ijcard.2013.06.024 Vilar-Gomez E, 2015, GASTROENTEROLOGY, V149, P367, DOI 10.1053/j.gastro.2015.04.005 Wettstein G, 2017, HEPATOL COMMUN, V1, P524, DOI 10.1002/hep4.1057 Yau H, 2013, CURR DIABETES REP, V13, P329, DOI 10.1007/s11892-013-0378-8 NR 65 TC 176 Z9 208 U1 0 U2 11 PU DOVE MEDICAL PRESS LTD PI ALBANY PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND SN 1178-7007 J9 DIABET METAB SYND OB JI Diabetes Metab. Syndr. Obes. PY 2018 VL 11 BP 533 EP 542 DI 10.2147/DMSO.S146339 PG 10 WC Endocrinology & Metabolism WE Science Citation Index Expanded (SCI-EXPANDED) SC Endocrinology & Metabolism GA GX1JQ UT WOS:000447473600002 PM 30288073 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Haigh, L McPherson, S Mathers, JC Anstee, QM AF Haigh, Laura McPherson, Stuart Mathers, John C. Anstee, Quentin M. TI Nutrigenetics-based intervention approach for adults with non-alcoholic fatty liver disease (NAFLD): study protocol for a randomised controlled feasibility trial SO BMJ OPEN LA English DT Article ID MEDITERRANEAN DIET; PHYSICAL-ACTIVITY; CARDIOVASCULAR-DISEASE; HEPATIC STEATOSIS; GENETIC-VARIATION; WEIGHT-LOSS; PNPLA3; POLYMORPHISM; RISK; CARBOHYDRATE AB Introduction Lifestyle interventions targeting weight loss and improved dietary patterns are the recommended treatment for non-alcoholic fatty liver disease (NAFLD). However, the effectiveness of current established diet therapies is suboptimal. The patatin-like phospholipase domain containing 3 (PNPLA3) gene modifies disease outcome and hepatic lipid handling, but the role of PNPLA3 variants in modulating responsiveness to different diet therapies is unknown. Methods and analysis This project aims to assess the feasibility of conducting a genotype-driven randomised controlled trial (RCT) investigating the differential response to a Mediterranean diet (MD) intervention of NAFLD patients according to genotype for the rs738409 (I148M) variant of PNPLA3. A single-centre randomised controlled feasibility trial will be undertaken. We will recruit 60 adults with NAFLD from a tertiary hepatology centre in England. In a cross-over design, participants will undertake Diet 1 (MD) and Diet 2 (control) for 4 weeks, in random order (1:1 allocation), separated by a 4 weeks washout period. Participants will complete one-to-one diet and lifestyle consultations at baseline, end of diet phase 1, end of washout and end of diet phase 2. Participants will be advised to maintain baseline levels of physical activity and body weight. The primary outcome is the acceptability and feasibility of the intervention protocol. Secondary outcomes include exploratory assessment of liver fibrosis biomarkers and lipid biomarkers. Ethics and dissemination Ethical approval was granted by East of Scotland Research Ethics Service REC 1 (19/ES/0112). Results will be disseminated through peer-reviewed journals and presented at local, national and international meetings and conferences. The findings of this trial will lay the foundation for a future definitive RCT by informing trial design and optimising the intervention diets, instruments and procedures. C1 [Haigh, Laura; McPherson, Stuart; Anstee, Quentin M.] Newcastle Tyne Hosp NHS Trust, Reg Liver Unit, Newcastle Upon Tyne, Tyne & Wear, England. [Haigh, Laura; McPherson, Stuart; Anstee, Quentin M.] Newcastle Univ, Fac Med Sci, Newcastle Upon Tyne, Tyne & Wear, England. [Mathers, John C.] Newcastle Univ, Human Nutr Res Ctr, Newcastle Upon Tyne, Tyne & Wear, England. C3 Newcastle Upon Tyne Hospitals NHS Foundation Trust; Newcastle University - UK; Newcastle University - UK RP Haigh, L (通讯作者)，Newcastle Tyne Hosp NHS Trust, Reg Liver Unit, Newcastle Upon Tyne, Tyne & Wear, England.; Haigh, L (通讯作者)，Newcastle Univ, Fac Med Sci, Newcastle Upon Tyne, Tyne & Wear, England. EM l.haigh3@newcastle.ac.uk RI Anstee, Quentin M/L-2981-2013 OI Anstee, Quentin M/0000-0002-9518-0088; McPherson, Stuart/0000-0002-5638-2453; Haigh, Laura/0000-0002-9229-4127 FU NIHR Newcastle Biomedical Research Centre (BRC) [BRC-1215-20001]; National Institute for Health Research (NIHR); Innovative Medicines Initiative (IMI2) Programme of the European Union [777377] FX This research was funded by the NIHR Newcastle Biomedical Research Centre (BRC) (grant number BRC-1215-20001). The NIHR Newcastle Biomedical Research Centre (BRC) is a partnership between Newcastle Hospitals NHS Foundation Trust and Newcastle University, funded by the National Institute for Health Research (NIHR). QMA is a member of the LITMUS (Liver Investigation: Testing Marker Utility in Steatohepatitis) consortium funded by the Innovative Medicines Initiative (IMI2) Programme of the European Union (Grant Agreement 777377). 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Consequently, NAFLD has become a leading indication for liver transplantation. Although genetic factors play an important role in the pathogenesis of NAFLD, detrimental lifestyle trends favoring a calorically unrestricted diet rich in carbohydrates and unsaturated fat, prolonged sedentary periods or limited physical activity have major metabolic implications. In aggregate these physiological dysregulations constitute the main risk factors for the metabolic syndrome and NAFLD. The cornerstone of the treatment of NAFLD, is lifestyle changes, including modifications to diet and physical activity, to reduce body weight and liver fat, however adherence is notoriously poor and the epidemic of NAFLD continues to grow unimpeded. In the face of this unmet clinical need, the pharmacologic therapy of NAFLD has been expanding as the varied mechanistic pathways of NAFLD are elucidated. Beyond these approaches to treating NAFLD, the prevention of other liver diseases is additionally important. Chief among these is alcoholic liver disease, and heavy use is detrimental irrespective of underlying NAFLD. However, the impact of mild to moderate alcohol use in patients with mild or nonadvanced forms NAFLD is undefined. This article summarizes the results of the International Liver Transplantation Society consensus meeting on NAFLD in liver transplantation. It describes the available evidence and provides consensus guidance on the lifestyle and pharmacologic therapies of NAFLD, and the consensus position on alcohol use in patients with NAFLD. C1 [Ratziu, Vlad] Sorbonne Univ, Inst Cardiometab & Nutr, Hosp Pitie Salpetriere, Paris, France. [Ghabril, Marwan] Indiana Univ Sch Med, Div Gastroenterol & Hepatol, Indianapolis, IN 46202 USA. [Romero-Gomez, Manuel] Univ Seville, Univ Hosp, Inst Biomed Seville, Seville, Spain. [Svegliati-Baroni, Gianluca] Politech Univ Marche, Dept Gastroenterol, Ancona, Italy. [Svegliati-Baroni, Gianluca] Politech Univ Marche, Obes Ctr, Ancona, Italy. C3 Assistance Publique Hopitaux Paris (APHP); Hopital Universitaire Pitie-Salpetriere - APHP; Sorbonne Universite; Indiana University System; Indiana University Bloomington; Consejo Superior de Investigaciones Cientificas (CSIC); University of Sevilla; CSIC-JA-USE - Instituto de Biomedicina de Sevilla (IBIS); Marche Polytechnic University; Marche Polytechnic University RP Ratziu, V (通讯作者)，Sorbonne Univ, Inst Cardiometab & Nutr, Hosp Pitie Salpetriere, Paris, France. 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Article DE non-alcoholic fatty liver disease; fatty liver index; liver fibrosis; Mediterranean diet; PERSIAN cohort ID WEIGHT-LOSS; PATTERNS; INDEX AB BackgroundDespite evidence supporting the beneficial effects of the Mediterranean diet (MedDiet) on hepatic steatosis in subjects with non-alcoholic fatty liver disease (NAFLD), the relationship of the MedDiet with hepatic fibrosis is as yet unclear. The aim of the present study was to explore this association in Iranian adults with NAFLD. MethodsThis cross-sectional study included 3,325 subjects with NAFLD from the Ravansar Noncommunicable Disease (RaNCD) cohort. Dietary intake data were collected by a validated food frequency questionnaire (FFQ). The MedDiet score was computed based on a nine-point scale constructed by Trichopoulou et al. Fatty liver index (FLI) and fibrosis-4 (FIB-4) index were used to predict hepatic steatosis and fibrosis in the population. Multivariate regression models were applied to determine associations. ResultsSubjects in the highest tertile of MedDiet score had a higher platelet and a lower weight, total cholesterol (TC), LDL-c, and FLI than those in the lowest tertile (p-value < 0.05). Adherence to the MedDiet was associated with a 7.48 (95%CI: 5.376 to 9.603; p-value: 0.001) x 10(3)/mu l; -0.417 (95%CI: -0.819 to -0.014; p-value: 0.042) kg, -2.505 (95%CI: -3.835 to -1.175; p-value: 0.001) mg/dl; and -1.93 (95%CI: -2.803 to -1.061; p-value: 0.001) mg/dl change in platelet, weight, TC, and LDL-c for each SD increase in the score, respectively. A significant linear trend was observed in odds of hepatic fibrosis across the tertiles of the MedDiet score (P-trend: 0.008). This linear trend was attenuated but remained significant after the adjustment of the relevant confounders (P-trend: 0.032). Adherence to the MedDiet was independently associated with about 16% lower odds of having hepatic fibrosis in patients with NAFLD for each SD increase in the score. ConclusionAdherence to the MedDiet characterized by a high intake of whole grains, fruits, vegetables, legumes, nuts, and fish was associated with a lower risk of having hepatic fibrosis in patients with NAFLD. Further studies are required to elucidate the causal relationship of observed association in individuals of all ages, ethnicities, and etiologies of hepatic steatosis. C1 [Miryan, Mahsa] Kermanshah Univ Med Sci, Student Res Comm, Kermanshah, Iran. [Miryan, Mahsa; Soleimani, Davood; Pasdar, Yahya] Kermanshah Univ Med Sci, Sch Nutr Sci & Food Technol, Nutr Sci Dept, Kermanshah, Iran. [Darbandi, Mitra; Najafi, Farid; Pasdar, Yahya] Kermanshah Univ Med Sci, Hlth Inst, Res Ctr Environm Determinants Hlth RCEDH, Kermanshah, Iran. [Moradi, Mozhgan] Kermanshah Univ Med Sci, Sch Med, Internal Med Dept, Kermanshah, Iran. [Najafi, Farid; Pasdar, Yahya] Kermanshah Univ Med Sci, Cardiovasc Res Ctr, Kermanshah, Iran. [Soleimani, Davood] Kermanshah Univ Med Sci, Res Ctr Oils & Fats, Kermanshah, Iran. C3 Kermanshah University of Medical Sciences; Kermanshah University of Medical Sciences; Kermanshah University of Medical Sciences; Kermanshah University of Medical Sciences; Kermanshah University of Medical Sciences; Kermanshah University of Medical Sciences RP Soleimani, D; Pasdar, Y (通讯作者)，Kermanshah Univ Med Sci, Sch Nutr Sci & Food Technol, Nutr Sci Dept, Kermanshah, Iran.; Pasdar, Y (通讯作者)，Kermanshah Univ Med Sci, Hlth Inst, Res Ctr Environm Determinants Hlth RCEDH, Kermanshah, Iran.; Pasdar, Y (通讯作者)，Kermanshah Univ Med Sci, Cardiovasc Res Ctr, Kermanshah, Iran.; Soleimani, D (通讯作者)，Kermanshah Univ Med Sci, Res Ctr Oils & Fats, Kermanshah, Iran. EM nut.davood@gmail.com; yahya.pasdar@kums.ac.ir RI Pasdar, Yahya/J-9064-2017; Najafi, Farid/JSL-1581-2023 FU Kermanshah University of Medical Sciences, Kermanshah, Iran [IR.KUMS.REC.1401.223]; Iranian Ministry of Health and Medical Education [700/534]; PERSIAN cohort FX We sincerely appreciate all participants and the Student Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran (IR.KUMS.REC.1401.223) and PERSIAN cohort Study collaborators for their financial support of the study. The Iranian Ministry of Health and Medical Education has contributed to the funding used in the PERSIAN Cohort through Grant no 700/534. 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Nutr. PD FEB 22 PY 2023 VL 10 AR 1062008 DI 10.3389/fnut.2023.1062008 PG 8 WC Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Nutrition & Dietetics GA 9Q9ZW UT WOS:000945315900001 PM 36908910 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Bonfiglio, C Cuccaro, F Campanella, A Rosso, N Tatoli, R Giannelli, G Donghia, R AF Bonfiglio, Caterina Cuccaro, Francesco Campanella, Angelo Rosso, Natalia Tatoli, Rossella Giannelli, Gianluigi Donghia, Rossella TI Effect of Intake of Extra Virgin Olive Oil on Mortality in a South Italian Cohort with and without NAFLD SO NUTRIENTS LA English DT Article DE extra-virgin olive oil; non-alcoholic fatty liver disease (NAFLD); survival ID MEDITERRANEAN DIET; HEALTH; CONSUMPTION; ADHERENCE; BENEFITS; MODEL; RISK AB Background: Extra-virgin olive oil (EVOO) is the main source of seasoning fat in the Mediterranean diet and it is one of the components with known protective factors on chronic-degenerative disease. We aimed to evaluate the effect of a medium-high level of oil consumption on mortality in a cohort with good adherence to the Mediterranean diet. Methods: A total of 2754 subjects who had completed the food questionnaire in the Multicenter Italian study on Cholelithiasis (MICOL) cohort were included in the study. EVOO consumption was categorized in four levels (<20 g/die, 21-30 g/die, 31-40 g/die, >40 g/die). We performed a flexible parametric survival model to assess mortality by EVOO consumption level adjusted for some covariates. We also performed the analysis on subjects with and without non-alcoholic fatty liver disease (NAFLD) to evaluate the effects of oil in this more fragile sub-cohort. Results: We found a statistically significant negative effect on mortality for the whole sample when EVOO consumption was used, both as a continuous variable and when categorized. The protective effect was stronger in the sub-cohort with NAFLD, especially for the highest levels of EVOO consumption (HR = 0.58 with p < 0.05). Conclusions: Our study has shown a protective effect of EVOO consumption towards all causes of mortality. Despite the higher caloric intake, the protective power is greater for a consumption >40 g/day in both the overall cohort and the sub-cohorts with and without NAFLD. C1 [Bonfiglio, Caterina; Campanella, Angelo; Tatoli, Rossella; Giannelli, Gianluigi; Donghia, Rossella] IRCCS Saverio de Bellis, Natl Inst Gastroenterol, I-70013 Castellana Grotte, Italy. [Cuccaro, Francesco] Local Hlth Unit Barletta Andria Trani, I-76121 Barletta, Italy. [Rosso, Natalia] Fdn Italiana Fegato, AREA Sciegce Pk, I-34149 Trieste, Italy. C3 IRCCS Saverio de Bellis RP Bonfiglio, C; Donghia, R (通讯作者)，IRCCS Saverio de Bellis, Natl Inst Gastroenterol, I-70013 Castellana Grotte, Italy. EM catia.bonfiglio@irccsdebellis.it; angelo.campanella@irccsdebellis.it; francescocuccaroepi@gmail.com; natalia.rosso@fegato.it; rossella.tatoli@irccsdebellis.it; gianluigi.giannelli@irccdebellis.it; rossella.donghia@irccsdebellis.it RI Cuccaro, Francesco/J-9067-2016; Rosso, Natalia/K-9035-2016; Giannelli, Gianluigi/A-8169-2012 OI Cuccaro, Francesco/0000-0002-7012-2885; Bonfiglio, Caterina/0000-0002-8650-348X; Rosso, Natalia/0000-0002-4251-3547; Giannelli, Gianluigi/0000-0002-5140-8060; Tatoli, Rossella/0000-0002-7891-6057; Campanella, Angelo/0000-0002-5044-4625; Donghia, Rossella/0000-0002-9140-673X FU We thank: the MICOL III group, Giovanni Misciagna, Maria Gabriella Caruso, Alberto Ruben Osella and all the volunteers who participated in the study. FX We thank: the MICOL III group, Giovanni Misciagna, Maria Gabriella Caruso, Alberto Ruben Osella and all the volunteers who participated in the study. 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The upstream mechanisms underlying this association require further elucidation. Recent studies suggest that the interactive network comprising the "gut-adipose axis" and "gut-pancreatic axis" represents a core component of the comorbidity mechanism. This network initiates with gut microbiota dysbiosis, which alters short-chain fatty acids (SCFAs), lipopolysaccharide (LPS), branched-chain amino acids (BCAAs), secondary bile acids(SBAs), and other microbial metabolites, as well as endocrine signals such as the endocannabinoid system (ECS) and incretin hormones. This network simultaneously influences adipose tissue and the pancreas to coordinate glucose and lipid homeostasis. Therefore, this paper proposes the "Common Messengers, Dual-Axis Convergence" model to systematically elucidate how the gut microbiota, through a shared set of messenger molecules, simultaneously and independently drives lipid and glucose metabolic dysregulation via the gut-adipose and gut-pancreatic axes, ultimately leading to the comorbidity of MAFLD and T2DM. C1 [Liang, Jiahui; Chu, Yunhang] Changchun Univ Tradit Chinese Med, Gastroenterol, Changchun, Jilin, Peoples R China. [Chen, Xingyu; Leng, Yan] Changchun Univ Tradit Chinese Med, Affiliated Hosp, Dept Liver Spleen & Gastroenterol, Changchun, Jilin, Peoples R China. C3 Changchun University of Chinese Medicine; Changchun University of Chinese Medicine RP Leng, Y (通讯作者)，Changchun Univ Tradit Chinese Med, Affiliated Hosp, Dept Liver Spleen & Gastroenterol, Changchun, Jilin, Peoples R China. EM ccucm_ly@outlook.com RI chu, yunhang/ONI-6655-2025; liang, jiahui/OOJ-8878-2025 FU Jilin Provincial Science and Technology Development Program Project [20240304068SF]; Jilin Provincial Department of Education Science and Technology Research Project [JJKH20250641KJ] FX The author(s) declare financial support was received for the research and/or publication of this article. Jilin Provincial Science and Technology Development Program Project (No.: 20240304068SF); Jilin Provincial Department of Education Science and Technology Research Project (No.: JJKH20250641KJ). 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Endocrinol. PD OCT 31 PY 2025 VL 16 AR 1664233 DI 10.3389/fendo.2025.1664233 PG 13 WC Endocrinology & Metabolism WE Science Citation Index Expanded (SCI-EXPANDED) SC Endocrinology & Metabolism GA 9SF6A UT WOS:001613786300001 PM 41244044 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Milic, S Mikolasevic, I Krznaric-Zrnic, I Stanic, M Poropat, G Stimac, D Vlahovic-Palcevski, V Orlic, L AF Milic, Sandra Mikolasevic, Ivana Krznaric-Zrnic, Irena Stanic, Marija Poropat, Goran Stimac, Davor Vlahovic-Palcevski, Vera Orlic, Lidija TI Nonalcoholic steatohepatitis: emerging targeted therapies to optimize treatment options SO DRUG DESIGN DEVELOPMENT AND THERAPY LA English DT Review DE nonalcoholic fatty liver disease; therapy; metabolic syndrome; insulin resistance ID FATTY-LIVER-DISEASE; RENIN-ANGIOTENSIN SYSTEM; CLINICAL-PRACTICE GUIDELINES; VITAMIN-E; METABOLIC SYNDROME; 25-HYDROXYVITAMIN D-3; URSODEOXYCHOLIC ACID; MEDITERRANEAN DIET; INSULIN-RESISTANCE; RANDOMIZED-TRIAL AB Diet and lifestyle changes have led to worldwide increases in the prevalences of obesity and metabolic syndrome, resulting in substantially greater incidence of nonalcoholic fatty liver disease (NAFLD). NAFLD is considered a hepatic manifestation of metabolic syndrome and is related to diabetes, insulin resistance, central obesity, hyperlipidemia, and hypertension. Nonalcoholic steatohepatitis (NASH) is an entity that describes liver inflammation due to NAFLD. Growing evidence suggests that NAFLD is a multisystem disease with a clinical burden that is not only confined to liver-related morbidity and mortality, but that also affects several extra-hepatic organs and regulatory pathways. Thus, NAFLD is considered an important public health issue, but there is currently no effective therapy for all NAFLD patients in the general population. Studies seeking optimal therapy for NAFLD and NASH have not yet led to development of a universal protocol for treating this growing problem. Several pharmacological agents have been studied in an effort to improve insulin resistance and the proinflammatory mediators that may be responsible for NASH progression. Cardiovascular risk factors are highly prevalent among NASH patients, and the backbone of treatment regimens for these patients still comprises general lifestyle interventions, including dietary changes and increased physical activity. Vitamin E and thiazolidinedione derivatives are currently the most evidence-based therapeutic options, but only limited clinical evidence is available regarding their long-term efficacy and safety. Vitamin D and renin-angiotensin-aldosterone system blockers are promising drugs that are currently being intensively investigated for use in NAFLD/NASH patients. C1 [Milic, Sandra; Mikolasevic, Ivana; Krznaric-Zrnic, Irena; Poropat, Goran; Stimac, Davor] UHC Rijeka, Dept Gastroenterol, Rijeka 51000, Croatia. [Mikolasevic, Ivana; Orlic, Lidija] UHC Rijeka, Dept Nephrol Dialysis & Kidney Transplantat, Rijeka 51000, Croatia. [Stanic, Marija] UHC Rijeka, Dept Hematol, Rijeka 51000, Croatia. [Vlahovic-Palcevski, Vera] Univ Rijeka, UHC Rijeka, Sch Med, Dept Clin Pharmacol, Rijeka, Croatia. C3 University of Rijeka; University of Rijeka; University of Rijeka; University of Rijeka RP Milic, S (通讯作者)，UHC Rijeka, Dept Gastroenterol, Kresimirova 42, Rijeka 51000, Croatia. 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Dev. Ther. PY 2015 VL 9 BP 4835 EP 4845 DI 10.2147/DDDT.S64877 PG 11 WC Chemistry, Medicinal; Pharmacology & Pharmacy WE Science Citation Index Expanded (SCI-EXPANDED) SC Pharmacology & Pharmacy GA CP7GY UT WOS:000360056400002 PM 26316717 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Martín-Pozuelo, G González-Barrio, R Barberá, GG Albalat, A García-Alonso, J Mullen, W Mischak, H Periago, MJ AF Martin-Pozuelo, Gala Gonzalez-Barrio, Rocio Barbera, Gonzalo G. Albalat, Amaya Garcia-Alonso, Javier Mullen, William Mischak, Harald Periago, Maria Jesus TI Tomato Juice Consumption Modifies the Urinary Peptide Profile in Sprague-Dawley Rats with Induced Hepatic Steatosis SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES LA English DT Article DE non-alcoholic fatty liver disease (NAFLD); tomato; biomarkers; peptidome; proteome; urine; capillary electrophoresis coupled to a mass spectrometer (CE-MS); diagnosis; liver ID FATTY LIVER-DISEASE; MASS-SPECTROMETRY; NONALCOHOLIC STEATOHEPATITIS; CAPILLARY-ELECTROPHORESIS; BIOMARKER DISCOVERY; BIOACTIVE COMPOUNDS; MEDITERRANEAN DIET; OXIDATIVE STRESS; LIPID-METABOLISM; IV COLLAGEN AB Non-alcoholic fatty liver disease (NAFLD) is the most common liver disorder in Western countries, with a high prevalence, and has been shown to increase the risk of type 2 diabetes, cardiovascular disease (CVD), etc. Tomato products contain several natural antioxidants, including lycopene-which has displayed a preventive effect on the development of steatosis and CVD. Accordingly, the aim of the present work was to evaluate the effect of tomato juice consumption on the urinary peptide profile in rats with NAFLD induced by an atherogenic diet and to identify potential peptide biomarkers for diagnosis. Urine samples, collected weekly for four weeks, were analyzed by capillary electrophoresis (CE) coupled to a mass spectrometer (MS). A partial least squares-discriminant analysis (PLS-DA) was carried out to explore the association between differential peptides and treatments. Among the 888 peptides initially identified, a total of 55 were obtained as potential biomarkers. Rats with steatosis after tomato juice intake showed a profile intermediate between that of healthy rats and that of rats with induced hepatic steatosis. Accordingly, tomato products could be considered as a dietary strategy for the impairment of NAFLD, although further research should be carried out to develop a specific biomarkers panel for NAFLD. C1 [Martin-Pozuelo, Gala; Gonzalez-Barrio, Rocio; Garcia-Alonso, Javier; Periago, Maria Jesus] Univ Murcia, Fac Vet, Dept Food Technol Food Sci & Nutr, Reg Campus Int Excellence Campus Mare Nostrum, E-30071 Murcia, Spain. [Martin-Pozuelo, Gala; Gonzalez-Barrio, Rocio; Garcia-Alonso, Javier; Periago, Maria Jesus] Univ Murcia, Univ Clin Hosp Virgen de la Arrixaca, Biomed Res Inst Murcia IMIB Arrixaca UMU, Murcia 30120, Spain. [Barbera, Gonzalo G.] CSIC CEBAS, Dept Soil & Water Conservat, Campus Univ, Murcia 30100, Spain. [Albalat, Amaya; Mullen, William; Mischak, Harald] Univ Glasgow, Inst Cardiovasc & Med Sci, Glasgow G12 8TA, Lanark, Scotland. [Mischak, Harald] Mosa Diagnost GmbH, D-30659 Hannover, Germany. C3 University of Murcia; University of Murcia; Hospital Clinico Universitario Virgen de la Arrixaca; Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Centro de Edafologia y Biologia Aplicada del Segura (CEBAS); University of Glasgow; Modular Open Systems Approach (MOSA) Solutions RP Martín-Pozuelo, G (通讯作者)，Univ Murcia, Fac Vet, Dept Food Technol Food Sci & Nutr, Reg Campus Int Excellence Campus Mare Nostrum, E-30071 Murcia, Spain.; Martín-Pozuelo, G (通讯作者)，Univ Murcia, Univ Clin Hosp Virgen de la Arrixaca, Biomed Res Inst Murcia IMIB Arrixaca UMU, Murcia 30120, Spain. EM galamartin@um.es; rgbarrio@um.es; gbarbera@cebas.csic.es; amaya.albalat@stir.ac.uk; fjgarcia@um.es; william.mullen@glasgow.ac.uk; gbarbera@cebas.csic.es; mjperi@um.es RI Gonzalez-Barrio, Rocío/F-2180-2018; Barbera, Gonzalo/D-8386-2011; Martín-Pozuelo, Gala/HMV-7220-2023; Mullen, William/GWC-8078-2022; González Barberá, Gonzalo/D-8386-2011; Albalat, Amaya/C-2756-2014; PERIAGO, MARIA JESUS/K-5251-2017 OI Gonzalez-Barrio, Rocío/0000-0002-6648-5229; Martin Pozuelo del Pozo, Gala/0000-0002-2844-7635; González Barberá, Gonzalo/0000-0003-2166-0633; Albalat, Amaya/0000-0002-8606-2995; Mischak, Harald/0000-0003-0323-0306; PERIAGO, MARIA JESUS/0000-0003-2096-0167 FU projects Spanish Ministerio de Economia y Competitividad (MINECO)/Fondo Europeo de Desarrollo Regional (FEDER-EU) [BIO2012-38103]; University of Murcia (Murcia, Spain); Spanish Ministerio de Ciencia e Innovacion (MICINN) FX This research was supported by the projects Spanish Ministerio de Economia y Competitividad (MINECO)/Fondo Europeo de Desarrollo Regional (FEDER-EU) BIO2012-38103. We would also like to thank Zumos Hesperia Filab and Juver Alimentacion (Cabezo de Torres, Murcia, Spain) for providing the tomato juice samples. Gala Martin-Pozuelo thanks the University of Murcia (Murcia, Spain) for a pre-doctoral contract and Rocio Gonzalez Barrio thanks the Spanish Ministerio de Ciencia e Innovacion (MICINN) for a post-doctoral contract ("Juan de la Cierva" Program). 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J. Mol. Sci. PD NOV PY 2016 VL 17 IS 11 AR 1789 DI 10.3390/ijms17111789 PG 18 WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary WE Science Citation Index Expanded (SCI-EXPANDED) SC Biochemistry & Molecular Biology; Chemistry GA ED4HV UT WOS:000388809600023 PM 27792191 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Ryyti, R Pemmari, A Peltola, R Hamalainen, M Moilanen, E AF Ryyti, Riitta Pemmari, Antti Peltola, Rainer Hamalainen, Mari Moilanen, Eeva TI Effects of Lingonberry (Vaccinium vitis-idaea L.) Supplementation on Hepatic Gene Expression in High-Fat Diet Fed Mice SO NUTRIENTS LA English DT Article DE lingonberry; low-grade inflammation; gene expression; liver; high-fat diet; lipid metabolism; nonalcoholic fatty liver disease (NAFLD) ID INSULIN-RESISTANCE; LIVER-DISEASE; MEDITERRANEAN DIET; LEPTIN RESISTANCE; RISK-FACTORS; LIPOCALIN 2; OBESITY; STEATOSIS; MOUSE; INFLAMMATION AB The prevalence of nonalcoholic fatty liver disease (NAFLD) is growing worldwide in association with Western-style diet and increasing obesity. Lingonberry (Vaccinium vitis-idaea L.) is rich in polyphenols and has been shown to attenuate adverse metabolic changes in obese liver. This paper investigated the effects of lingonberry supplementation on hepatic gene expression in high-fat diet induced obesity in a mouse model. C57BL/6N male mice were fed for six weeks with either a high-fat (HF) or low-fat (LF) diet (46% and 10% energy from fat, respectively) or HF diet supplemented with air-dried lingonberry powder (HF + LGB). HF diet induced a major phenotypic change in the liver, predominantly affecting genes involved in inflammation and in glucose and lipid metabolism. Lingonberry supplementation prevented the effect of HF diet on an array of genes (in total on 263 genes) associated particularly with lipid or glucose metabolic process (such as Mogat1, Plin4, Igfbp2), inflammatory/immune response or cell migration (such as Lcn2, Saa1, Saa2, Cxcl14, Gcp1, S100a10) and cell cycle regulation (such as Cdkn1a, Tubb2a, Tubb6). The present results suggest that lingonberry supplementation prevents HF diet-induced adverse changes in the liver that are known to predispose the development of NAFLD and its comorbidities. The findings encourage carrying out human intervention trials to confirm the results, with the aim of recommending the use of lingonberries as a part of healthy diet against obesity and its hepatic and metabolic comorbidities. C1 [Ryyti, Riitta; Pemmari, Antti; Hamalainen, Mari; Moilanen, Eeva] Tampere Univ, Fac Med & Hlth Technol, Immunopharmacol Res Grp, Tampere, Finland. [Ryyti, Riitta; Pemmari, Antti; Hamalainen, Mari; Moilanen, Eeva] Tampere Univ Hosp, Tampere, Finland. [Peltola, Rainer] Nat Resources Inst Finland, Bioecon & Environm, Rovaniemi 96200, Finland. C3 Tampere University; Tampere University; Tampere University Hospital; Natural Resources Institute Finland (Luke) RP Moilanen, E (通讯作者)，Tampere Univ, Fac Med & Hlth Technol, Immunopharmacol Res Grp, Tampere, Finland.; Moilanen, E (通讯作者)，Tampere Univ Hosp, Tampere, Finland. EM riitta.ryyti@tuni.fi; antti.pemmari@tuni.fi; rainer.peltola@luke.fi; eeva.moilanen@tuni.fi RI ; Pemmari, Antti/GQZ-6812-2022 OI Hämäläinen, Mari/0000-0002-6409-3758; Moilanen, Eeva/0000-0002-8577-0316; Ryyti, Riitta/0000-0003-2428-6608; Pemmari, Antti/0000-0002-8187-1216 FU European Regional Development Fund (EDRF) [A72934] FX The study was funded by the European Regional Development Fund (EDRF), grant number A72934. 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Expanded (SCI-EXPANDED) SC Nutrition & Dietetics GA XJ5OO UT WOS:000726837200001 PM 34835949 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Kalafati, IP Borsa, D Dimitriou, M Revenas, K Kokkinos, A Dedoussis, GV AF Kalafati, Ioanna-Panagiota Borsa, Dimitra Dimitriou, Maria Revenas, Konstantinos Kokkinos, Alexander Dedoussis, George Vassilios TI Dietary patterns and non-alcoholic fatty liver disease in a Greek case-control study SO NUTRITION LA English DT Article DE NAFLD; Dietary patterns; Fatty liver; Diet; Greek; European ID SERUM URIC-ACID; 3RD NATIONAL-HEALTH; MEDITERRANEAN DIET; NUTRITION; RISK; MARKERS; ADULTS; NAFLD AB Objective: The aim of this study was to test the hypothesis that posteriori-derived dietary patterns of a Greek sample are associated with the odds for non-alcoholic fatty liver disease (NAFLD) and common NAFLD-related biomarkers. Methods: We recruited 351 individuals (134 NAFLD patients, 217 controls). NAFLD was diagnosed with abdominal ultrasound. Dietary intake data were collected through a semi-quantitative food frequency questionnaire of 172 items and dietary patterns were derived by factor analysis. Consumption of dietary patterns was divided into quartiles. Multivariate logistic and linear regression models were applied to investigate associations of dietary patterns with NAFLD odds and common NAFLD-associated biomarkers. Results: Four dietary patterns were identified. Adherence to the fast food-type dietary pattern was independently associated with higher odds for NAFLD. However, results were statistically significant only for the highest versus the lowest consumption (odds ratio, 3.9; P= 0.003). On the contrary, individuals in the second quartile of the unsaturated fatty acid dietary pattern had 55.7% reduced odds of developing NAFLD than those in the first quartile after adjusting for age, sex, energy intake, physical activity level, pack-years smoked, education years, and presence of metabolic syndrome (P= 0.039). The fast food-type pattern was further associated with higher levels of C-reactive protein and uric acid and the unsaturated fatty acid pattern with reduced levels of insulin and homeostatic model assessment of insulin resistance (P < 0.05). The prudent dietary pattern was associated with decreased triacylglycerol and uric acid levels (beta = 5.960; P = 0.037 and beta = 0.153; P= 0.035, respectively). Conclusion: This is the first study to indicate associations of dietary patterns with NAFLD in a European population. (C) 2018 Elsevier Inc. All rights reserved. C1 [Kalafati, Ioanna-Panagiota; Borsa, Dimitra; Dimitriou, Maria; Dedoussis, George Vassilios] Harokopio Univ Athens, Sch Hlth Sci & Educ, Dept Nutr & Dietet, Athens, Greece. [Revenas, Konstantinos] Laikon Gen Hosp, Radiol Dept, Athens, Greece. [Kokkinos, Alexander] Univ Athens, Laiko Gen Hosp, Sch Med, Dept Propaedeut Med 1, Athens, Greece. C3 Harokopio University Athens; Laiko General Hospital; National & Kapodistrian University of Athens; Laiko General Hospital RP Kalafati, IP (通讯作者)，Harokopio Univ Athens, Sch Hlth Sci & Educ, Dept Nutr & Dietet, Athens, Greece. EM nkalafati@gmail.com RI Kalafati, Ioanna Panagiota/AAJ-2287-2020; Dedoussis, George/AAN-7252-2021; Kokkinos, Alexander/ABI-6657-2020 OI Kalafati, Ioanna Panagiota/0000-0001-5572-7491; FU Greek General Secretariat for Research and Technology [890/2009] FX This study was funded by the project "Obesity and Metabolic Syndrome: Dietary Intervention with Greek Raisins in NAFLD/NASH. Investigation of Molecular Mechanisms" reviewed and approved by the Greek General Secretariat for Research and Technology (Cooperation 890/2009). CR Abid A, 2009, J HEPATOL, V51, P918, DOI 10.1016/j.jhep.2009.05.033 Adriano LS, 2016, BRIT J NUTR, V115, P2189, DOI 10.1017/S0007114516001410 Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644 Asrih M, 2014, CLIN NUTR, V33, P186, DOI 10.1016/j.clnu.2013.11.003 Buzzetti E, 2016, METABOLISM, V65, P1038, DOI 10.1016/j.metabol.2015.12.012 Hernandez-Rodas MC, 2015, INT J MOL SCI, V16, P25168, DOI 10.3390/ijms161025168 Chiu S, 2014, EUR J CLIN NUTR, V68, P416, DOI 10.1038/ejcn.2014.8 Choi HK, 2005, ARTHRITIS RHEUM-US, V52, P283, DOI 10.1002/art.20761 Choi JWJ, 2008, ARTHRIT RHEUM-ARTHR, V59, P109, DOI 10.1002/art.23245 Dimitriou M, 2016, PUBLIC HEALTH NUTR, V19, P1081, DOI 10.1017/S1368980015002244 Fakhoury-Sayegh N, 2017, NUTRIENTS, V9, DOI 10.3390/nu9111245 Jia Q, 2015, EUR J CLIN NUTR, V69, P914, DOI 10.1038/ejcn.2014.297 Kalafati IP, 2018, EUR J NUTR Kavouras SA, 2016, SCI SPORT, V31, pe47, DOI [10.1016/j.scispo.2016.01.007, 10.1016/j.scispo.2016.01.007, DOI 10.1016/J.SCISPO.2016.01.007] Kontogianni MD, 2014, CLIN NUTR, V33, P678, DOI 10.1016/j.clnu.2013.08.014 Liang J, 2015, EUR REV MED PHARMACO, V19, P305 Marina A, 2014, NUTRIENTS, V6, P4678, DOI 10.3390/nu6114678 Misciagna G, 2017, J NUTR HEALTH AGING, V21, P404, DOI 10.1007/s12603-016-0809-8 Morrison MC, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0139196 Oddy WH, 2013, AM J GASTROENTEROL, V108, P778, DOI 10.1038/ajg.2013.95 Parker HM, 2012, J HEPATOL, V56, P944, DOI 10.1016/j.jhep.2011.08.018 Robberecht H, 2017, INT J FOOD SCI NUTR, V68, P627, DOI 10.1080/09637486.2016.1269726 Rodríguez-Monforte M, 2017, EUR J NUTR, V56, P925, DOI 10.1007/s00394-016-1305-y Ryan MC, 2013, J HEPATOL, V59, P138, DOI 10.1016/j.jhep.2013.02.012 Scorletti E, 2014, HEPATOLOGY, V60, P1211, DOI 10.1002/hep.27289 Singh Divya, 2013, Indian J Endocrinol Metab, V17, P990, DOI 10.4103/2230-8210.122606 Sirota JC, 2013, METABOLISM, V62, P392, DOI 10.1016/j.metabol.2012.08.013 Sofi F, 2014, WORLD J GASTROENTERO, V20, P7339, DOI 10.3748/wjg.v20.i23.7339 Syauqy A, 2018, NUTRIENTS, V10, DOI 10.3390/nu10020143 Utzschneider KM, 2013, BRIT J NUTR, V109, P1096, DOI 10.1017/S0007114512002966 Wainwright P, 2016, INT J MOL SCI, V17, DOI 10.3390/ijms17030367 Wehmeyer MH, 2016, MEDICINE, V95, DOI 10.1097/MD.0000000000003887 Yang CQ, 2015, NUTRIENTS, V7, P4778, DOI 10.3390/nu7064778 Zade MR, 2016, LIVER INT, V36, P563, DOI 10.1111/liv.12990 Zelber-Sagil S, 2007, J HEPATOL, V47, P711, DOI 10.1016/j.jhep.2007.06.020 Zykova SN, 2015, NUTR J, V14, DOI 10.1186/s12937-015-0032-1 NR 36 TC 50 Z9 58 U1 0 U2 23 PU ELSEVIER SCIENCE INC PI NEW YORK PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA SN 0899-9007 EI 1873-1244 J9 NUTRITION JI Nutrition PD MAY PY 2019 VL 61 BP 105 EP 110 DI 10.1016/j.nut.2018.10.032 PG 6 WC Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Nutrition & Dietetics GA HR9FK UT WOS:000463464400017 PM 30708259 DA 2026-02-02 ER PT J AU Vahid, F Shivappa, N Hekmatdoost, A Hebert, JR Poustchi, H Shamsipour, A Eslamparast, T Meibodi, M Rahmani, D AF Vahid, Farhad Shivappa, Nitin Hekmatdoost, Azita Hebert, James R. Poustchi, Hossein Shamsipour, Ali Eslamparast, Tannaz Meibodi, Mohammad Rahmani, Diyako TI Association of Pro-inflammatory Dietary Intake and Non-Alcoholic Fatty Liver Disease: Findings from Iranian case-control study SO INTERNATIONAL JOURNAL FOR VITAMIN AND NUTRITION RESEARCH LA English DT Article DE Non-Alcoholic Fatty Liver Disease (NAFLD); Dietary Inflammatory Index (DII); Inflammation; Dietary assessment ID INSULIN-RESISTANCE; METABOLIC SYNDROME; MEDITERRANEAN DIET; INDEX DII; VITAMIN-E; EPIDEMIOLOGY; PREVALENCE; MARKERS; STEATOHEPATITIS; VALIDATION AB Background: Non-Alcoholic Fatty Liver Disease (NAFLD) is considered as a major health problem in the world. There is much evidence that diet and dietary factors play an important role in inflammation, and consequently pathogenesis of NAFLD. To investigate the role of diet in the development of inflammation, we can use the Dietary Inflammatory Index (DII), which has been shown to be predictive of levels of inflammatory markers. Methods: 295 incident cases were selected using the convenience-sampling procedure, and 704 controls randomly were selected from the same clinic and among the patients who had no hepatic steatosis and were frequency-matched on age (+/- 5 years) and sex. The DII was computed based on dietary intake from 168-item FFQ. Logistic regression models were used to estimate multivariable ORs. Results: Subjects in tertile 3 had 1.57 (95% CI: 1.13-2.20), 1.78 (95% CI: 1.19-2.67), and 2.02 (95% CI: 1.32-3.09) times higher odds of developing NAFLD, compared to subjects in tertile 1 in models 1 (adjusted for age), 2 (model 1 + BMI, education, smoking, alcohol, diabetes, low density lipoprotein, triglycerides) and 3 (model 2 + aspartate transaminase/alanine transaminase), respectively. When used as a continuous variable, one unit increase in DII was associated with 1.16 (95% CI: 1.05, 1.29), 1.21 (95% CI: 1.107, 1.37) and 1.25 (95% CI: 1.10, 1.43) increase in odds of NAFLD in models one, 2 and 3 respectively. Conclusion: Subjects who consumed a more pro-inflammatory diet were at increased odds of NAFLD. C1 [Vahid, Farhad] Arak Univ Med Sci, Sch Hlth, Dept Nutr Sci, Arak, Iran. [Shivappa, Nitin; Hebert, James R.] Univ South Carolina, Canc Prevent & Control Program, Columbia, SC 29208 USA. [Shivappa, Nitin; Hebert, James R.] Univ South Carolina, Arnold Sch Publ Hlth, Dept Epidemiol & Biostat, Columbia, SC 29208 USA. [Shivappa, Nitin; Hebert, James R.] Connecting Hlth Innovat LLC CHI, Columbia, SC USA. [Hekmatdoost, Azita; Shamsipour, Ali; Eslamparast, Tannaz; Meibodi, Mohammad] Shahid Beheshti Univ Med Sci, Fac Nutr & Food Technol, Natl Nutr & Food Technol Res Inst, Dept Clin Nutr, Tehran, Iran. [Hekmatdoost, Azita; Shamsipour, Ali; Eslamparast, Tannaz; Meibodi, Mohammad] Shahid Beheshti Univ Med Sci, Fac Nutr & Food Technol, Natl Nutr & Food Technol Res Inst, Dept Dietet, Tehran, Iran. [Poustchi, Hossein] Univ Tehran Med Sci, Digest Dis Res Inst, Liver & Pancreatobiliary Dis Res Grp, Tehran, Iran. [Rahmani, Diyako] Massey Univ, Dept Commun Journalism & Mkt, Palmerston North, New Zealand. C3 University of South Carolina System; University of South Carolina Columbia; University of South Carolina System; University of South Carolina Columbia; Connecting Health Innovations LLC; Shahid Beheshti University Medical Sciences; Shahid Beheshti University Medical Sciences; Tehran University of Medical Sciences; Massey University RP Vahid, F (通讯作者)，Arak Univ Med Sci, Sch Hlth, Dept Nutr Sci, Arak, Iran. EM farhadvahid@outlook.com RI Peykari, Niloofar/L-4521-2016; Hekmatdoost, Azita/AGM-6497-2022; Vahid, Farhad/L-7547-2018; Eslamparast, Tannaz/F-9772-2016; Rahmani, Diyako/AAD-4994-2019; Hebert, James/IUO-5628-2023; Shivappa, Nitin/X-2215-2018 OI Hekmatdoost, Azita/0000-0002-1944-0052; Vahid, Farhad/0000-0002-7380-3790; Eslamparast, Tannaz/0000-0002-0803-1245; Rahmani, Diyako/0000-0003-1230-7758; FU U.S. National Institute of Diabetes, Digestive and Kidney Diseases [NIDDK R44DK103377] FX Drs Shivappa and Hebert funded by grant NIDDK R44DK103377 from the U.S. National Institute of Diabetes, Digestive and Kidney Diseases. 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J. Vitam. Nutr. Res. PD JUN PY 2018 VL 88 IS 3-4 BP 144 EP 150 DI 10.1024/0300-9831/a000571 PG 7 WC Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Nutrition & Dietetics GA IK9LA UT WOS:000476915300004 PM 30887902 DA 2026-02-02 ER PT J AU Ferro, D Baratta, F Pastori, D Cocomello, N Colantoni, A Angelico, F Del Ben, M AF Ferro, Domenico Baratta, Francesco Pastori, Daniele Cocomello, Nicholas Colantoni, Alessandra Angelico, Francesco Del Ben, Maria TI New Insights into the Pathogenesis of Non-Alcoholic Fatty Liver Disease: Gut-Derived Lipopolysaccharides and Oxidative Stress SO NUTRIENTS LA English DT Review DE non-alcoholic fatty liver disease; lipopolysaccharide; oxidative stress; cardiovascular risk ID INCREASED INTESTINAL PERMEABILITY; CARDIOVASCULAR-DISEASE; MEDITERRANEAN DIET; VITAMIN-E; RISK-FACTORS; MICROBIOTA; ENDOTOXEMIA; PROGRESSION; RIFAXIMIN; STYLE AB Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide. The intricate NAFLD pathogenesis is summarized by the multiple-hits hypothesis, which combines all the environmental and genetic factors that promote the development of NAFLD into a single scenario. Among these, bacterial lipopolysaccharides (LPS) are derived from the overgrowth of Gram-negative bacteria and translocated mainly as a consequence of enhanced intestinal permeability. Furthermore, oxidative stress is increased in NAFLD as a consequence of reactive oxygen species (ROS) overproduction and a shortage of endogenous antioxidant molecules, and it is promoted by the interaction between LPS and the Toll-like receptor 4 system. Interestingly, oxidative stress, which has previously been described as being overexpressed in cardiovascular disease, could represent the link between LPS and the increased cardiovascular risk in NAFLD subjects. To date, the only effective strategy for the treatment of NAFLD and non-alcoholic steatohepatitis (NASH) is the loss of at least 5% body weight in overweight and/or obese subjects. However, the dose-dependent effects of multispecies probiotic supplementation on the serum LPS level and cardiometabolic profile in obese postmenopausal women were demonstrated. In addition, many antibiotics have regulatory effects on intestinal microbiota and were able to reduce serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), and tumor necrosis factor alpha (TNF-alpha) in NASH animal models. Regarding the oxidant status, a Mediterranean diet has been reported to reduce oxidant stress, while vitamin E at high daily dosages induced the resolution of NASH in 36% of treated patients. Silymarin had the positive effect of reducing transaminase levels in NAFLD patients and long-term treatment may also decrease fibrosis and slow liver disease progression in NASH. Finally, the influence of nutraceuticals on gut microbiota and oxidant stress in NAFLD patients has not yet been well elucidated and there are insufficient data either to support or refuse their use in these subjects. C1 [Ferro, Domenico; Baratta, Francesco; Pastori, Daniele; Cocomello, Nicholas; Colantoni, Alessandra; Del Ben, Maria] Sapienza Univ Rome, Dept Clin Internal Anesthet & Cardiovasc Sci, Clin Med 1, I-00185 Rome, Italy. [Angelico, Francesco] Sapienza Univ Rome, Dept Publ Hlth & Infect Dis, I-00185 Rome, Italy. C3 Sapienza University Rome; Sapienza University Rome RP Baratta, F (通讯作者)，Sapienza Univ Rome, Dept Clin Internal Anesthet & Cardiovasc Sci, Clin Med 1, I-00185 Rome, Italy. 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Perez-Diaz-del-Campo, N Marin-Alejandre, BA Cantero, I Monreal, JI Elorz, M Herrero, JI Benito-Boillos, A Riezu-Boj, J Milagro, F Tur, JA Martinez, JA Abete, I Zulet, MA AF Perez-Diaz-del-Campo, Nuria Marin-Alejandre, Bertha Araceli Cantero, Irene Monreal, J. Ignacio Elorz, Mariana Herrero, Jose Ignacio Benito-Boillos, Alberto Riezu-Boj, Jose, I Milagro, Fermin, I Tur, Josep A. Martinez, J. Alfredo Abete, Itziar Zulet, M. Angeles TI Differential response to a 6-month energy-restricted treatment depending on SH2B1 rs7359397 variant in NAFLD subjects: Fatty Liver in Obesity (FLiO) Study SO EUROPEAN JOURNAL OF NUTRITION LA English DT Article DE NAFLD; Gene-treatment interaction; Energy-restricted diet; Obesity; Weight-loss ID GENE POLYMORPHISMS; PRECISION NUTRITION; WEIGHT-LOSS; DISEASE; ASSOCIATION; MANAGEMENT; GUIDELINES; OUTCOMES; DIETS; ADIPONECTIN AB Purpose Non-alcoholic fatty liver disease (NAFLD) is worldwide recognized as the most common cause of chronic liver disease. Current NAFLD clinical management relies on lifestyle change, nevertheless, the importance of the genetic make-up on liver damage and the possible interactions with diet are still poorly understood. The aim of the study was to evaluate the influence of the SH2B1 rs7359397 genetic variant on changes in body composition, metabolic status and liver health after 6-month energy-restricted treatment in overweight/obese subjects with NAFLD. In addition, gene-treatment interactions over the course of the intervention were examined. Methods The SH2B1 genetic variant was genotyped in 86 overweight/obese subjects with NAFLD from the FLiO study (Fatty Liver in Obesity study). Subjects were metabolically evaluated at baseline and at 6-months. Liver assessment included ultrasonography, Magnetic Resonance Imaging, elastography, a lipidomic test (OWL(R)-test) and specific blood liver biomarkers. Additionally, body composition, general biochemical markers and dietary intake were determined. Results Both genotypes significantly improved their body composition, general metabolic status and liver health after following an energy-restricted strategy. Liver imaging techniques showed a greater decrease in liver fat content (- 44.3%, p < 0.001) and in serum ferritin levels (p < 0.001) in the carriers of the T allele after the intervention. Moreover, lipidomic analysis, revealed a higher improvement in liver status when comparing risk vs. no-risk genotype (p = 0.006 vs. p = 0.926, respectively). Gene-treatment interactions showed an increase in fiber intake and omega-3 fatty acid in risk genotype (p interaction = 0.056 and p interaction = 0.053, respectively), while a significant increase in MedDiet score was observed in both genotype groups (p = 0.020). Moreover, no-risk genotype presented a relevant decrease in hepatic iron as well as in MUFA intake (p = 0.047 and p = 0.034, respectively). Conclusion Subjects carrying the T allele of the rs7359397 polymorphism may benefit more in terms of hepatic health and liver status when prescribed an energy-restricted treatment, where a Mediterranean dietary pattern rich in fiber and other components such as omega-3 fatty acids might boost the benefits. C1 [Perez-Diaz-del-Campo, Nuria; Marin-Alejandre, Bertha Araceli; Cantero, Irene; Riezu-Boj, Jose, I; Milagro, Fermin, I; Martinez, J. Alfredo; Abete, Itziar; Zulet, M. Angeles] Univ Navarra, Fac Pharm & Nutr, Dept Nutr Food Sci & Physiol, Pamplona 31008, Spain. [Perez-Diaz-del-Campo, Nuria; Marin-Alejandre, Bertha Araceli; Cantero, Irene; Riezu-Boj, Jose, I; Milagro, Fermin, I; Martinez, J. Alfredo; Abete, Itziar; Zulet, M. Angeles] Univ Navarra, Fac Pharm & Nutr, Ctr Nutr Res, Pamplona 31008, Spain. [Monreal, J. Ignacio; Elorz, Mariana; Herrero, Jose Ignacio; Benito-Boillos, Alberto; Riezu-Boj, Jose, I; Milagro, Fermin, I; Martinez, J. Alfredo; Abete, Itziar; Zulet, M. Angeles] Navarra Inst Hlth Res IdiSNA, Pamplona 31008, Spain. [Monreal, J. Ignacio] Clin Univ Navarra, Clin Chem Dept, Pamplona 31008, Spain. [Elorz, Mariana; Benito-Boillos, Alberto] Clin Univ Navarra, Dept Radiol, Pamplona 31008, Spain. [Herrero, Jose Ignacio] Clin Univ Navarra, Liver Unit, Pamplona 31008, Spain. [Herrero, Jose Ignacio] Ctr Invest Biomed Red Enfermedades Hepat & Digest, Madrid 28029, Spain. [Milagro, Fermin, I; Tur, Josep A.; Martinez, J. Alfredo; Abete, Itziar; Zulet, M. Angeles] Inst Salud Carlos III, Biochem Res Ctr Network Physiopathol Obes & Nutr, Madrid 28029, Spain. [Tur, Josep A.] Univ Balearic Isl, Res Grp Community Nutr & Oxidat Stress, Palma De Mallorca 07122, Spain. [Tur, Josep A.] Balearic Isl Inst Hlth Res IDISBA, Palma De Mallorca 07122, Spain. C3 University of Navarra; University of Navarra; University of Navarra; University of Navarra; University of Navarra; University of Navarra; CIBER - Centro de Investigacion Biomedica en Red; CIBEREHD; Instituto de Salud Carlos III; Universitat de les Illes Balears RP Abete, I; Zulet, MA (通讯作者)，Univ Navarra, Fac Pharm & Nutr, Dept Nutr Food Sci & Physiol, Pamplona 31008, Spain.; Abete, I; Zulet, MA (通讯作者)，Univ Navarra, Fac Pharm & Nutr, Ctr Nutr Res, Pamplona 31008, Spain.; Abete, I; Zulet, MA (通讯作者)，Navarra Inst Hlth Res IdiSNA, Pamplona 31008, Spain.; Abete, I; Zulet, MA (通讯作者)，Inst Salud Carlos III, Biochem Res Ctr Network Physiopathol Obes & Nutr, Madrid 28029, Spain. EM nperezdiaz@alumni.unav.es; bmarin.1@alumni.unav.es; icgonzalez@unav.es; jimonreal@unav.es; marelorz@unav.es; iherrero@unav.es; albenitob@unav.es; pep.tur@uib.es; jalfmtz@unav.es; iabetego@unav.es; mazulet@unav.es RI Tur, Josep/AAE-5748-2020; Riezu-Boj, Jose-Ignacio/M-3748-2014; Milagro, Fermin I/F-2315-2015; Zulet, M./H-1317-2017; Carlón, Mariana/ABD-5128-2021; Pérez Díaz del Campo, Nuria/HGC-4070-2022; Martínez, J./K-8709-2014; Benito, Alberto/AAD-4201-2020 OI Tur, Josep/0000-0002-6940-0761; Riezu-Boj, Jose-Ignacio/0000-0002-1885-8457; Milagro, Fermin I/0000-0002-3228-9916; Pérez Díaz del Campo, Nuria/0000-0003-0479-8825; Benito, Alberto/0000-0002-1527-0092; Marín Alejane, Bertha Araceli/0000-0003-0741-8197 FU Health Department of the Government of Navarra [61/2015]; CIBERobn (Physiopathology of Obesity and Nutrition) [CB12/03/3002]; Fundacio La Marato de TV3 [201630.10] FX This research was funded by the Health Department of the Government of Navarra (61/2015), CIBERobn (Physiopathology of Obesity and Nutrition) (CB12/03/3002) and Fundacio La Marato de TV3 (201630.10). 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J. Nutr. PD SEP PY 2021 VL 60 IS 6 BP 3043 EP 3057 DI 10.1007/s00394-020-02476-x EA JAN 2021 PG 15 WC Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Nutrition & Dietetics GA TY4OR UT WOS:000609039800001 PM 33474638 DA 2026-02-02 ER PT J AU George, ES Reddy, A Nicoll, AJ Ryan, MC Itsiopoulos, C Abbott, G Johnson, NA Sood, S Roberts, SK Tierney, AC AF George, Elena S. Reddy, Anjana Nicoll, Amanda J. Ryan, Marno C. Itsiopoulos, Catherine Abbott, Gavin Johnson, Nathan A. Sood, Siddharth Roberts, Stuart K. Tierney, Audrey C. TI Impact of a Mediterranean diet on hepatic and metabolic outcomes in non-alcoholic fatty liver disease: The MEDINA randomised controlled trial SO LIVER INTERNATIONAL LA English DT Article DE dietary patterns; intrahepatic lipids; low-fat diet; Mediterranean diet; non-alcoholic fatty liver disease; non-alcoholic steatohepatitis ID WEIGHT-LOSS MAINTENANCE; INSULIN SENSITIVITY; PHYSICAL-ACTIVITY; MANAGEMENT; RESISTANCE; STEATOSIS; RISK; CARBOHYDRATE; INDIVIDUALS; SEVERITY AB Background Non-alcoholic fatty liver disease (NAFLD) is predominantly managed by lifestyle intervention, in the absence of effective pharmacotherapies. Mediterranean diet (MedDiet) is the recommended diet, albeit with limited evidence. Aims To compare an ad libitum MedDiet to low-fat diet (LFD) in patients with NAFLD for reducing intrahepatic lipids (IHL) by proton magnetic resonance spectroscopy (H-1-MRS). Secondary outcomes include insulin resistance by homeostatic model of assessment (HOMA-IR), visceral fat by bioelectrical impedance analysis (BIA), liver stiffness measurement (LSM) and other metabolic outcomes. Methods In this parallel multicentre RCT, subjects were randomised (1:1) to MedDiet or LFD for 12 weeks. Results Forty-two participants (25 females [60%], mean age 52.3 +/- 12.6 years) were included, 23 randomised to LFD and 19 to MedDiet.; 39 completed the study. Following 12 weeks, there were no between-group differences. IHL improved significantly within the LFD group (-17% [log scale]; p = .02) but not within the MedDiet group (-8%, p = .069). HOMA-IR reduced in the LFD group (6.5 +/- 5.6 to 5.5 +/- 5.5, p < .01) but not in the MedDiet group (4.4 +/- 3.2 to 3.9 +/- 2.3, p = .07). No differences were found for LSM (MedDiet 7.8 +/- 4.0 to 7.6 +/- 5.2, p = .429; LFD 11.8 +/- 14.3 to 10.8 +/- 10.2 p = .99). Visceral fat reduced significantly in both groups; LFD (-76% [log scale], p = <.0005), MedDiet (-61%, p = <.0005). Conclusions There were no between-group differences for hepatic and metabolic outcomes when comparing MedDiet to LFD. LFD improved IHL and insulin resistance. Significant improvements in visceral fat were seen within both groups. This study highlights provision of dietary interventions in free-living adults with NAFLD is challenging. C1 [George, Elena S.; Abbott, Gavin] Deakin Univ, Inst Phys Act & Nutr, Sch Exercise & Nutr Sci, Geelong, Vic 3220, Australia. [George, Elena S.; Reddy, Anjana; Itsiopoulos, Catherine; Tierney, Audrey C.] La Trobe Univ, Sch Allied Hlth Human Serv & Sport, Bundoora, Vic, Australia. [Nicoll, Amanda J.] Eastern Hlth, Dept Gastroenterol, Box Hill, Vic, Australia. [Ryan, Marno C.] St Vincents Hosp, Dept Gastroenterol & Hepatol, Fitzroy, Vic, Australia. [Itsiopoulos, Catherine] RMIT Univ, Sch Hlth & Biomed Sci, Melbourne, Vic, Australia. [Johnson, Nathan A.] Univ Sydney, Boden Collaborat Obes Nutr Exercise & Eating Diso, Sydney, NSW, Australia. [Sood, Siddharth] Melbourne Hlth, Dept Gastroenterol, Melbourne, Vic, Australia. [Roberts, Stuart K.] Alfred Hlth, Dept Gastroenterol, Prahran, Vic, Australia. [Roberts, Stuart K.] Monash Univ, Cent Clin Sch, Clayton, Vic, Australia. [Tierney, Audrey C.] Univ Limerick, Hlth Res Inst, Hlth Implementat Sci & Technol Ctr, Sch Allied Hlth, Limerick, Ireland. C3 Deakin University; La Trobe University; Eastern Health; St Vincent's Health; St Vincent's Hospital Melbourne; NSW Health; St Vincents Hospital Sydney; Royal Melbourne Institute of Technology (RMIT); University of Sydney; Melbourne Health; Alfred Health; Monash University; University of Limerick RP George, ES (通讯作者)，Deakin Univ, Inst Phys Act & Nutr, Sch Exercise & Nutr Sci, Geelong, Vic 3220, Australia. EM elena.george@deakin.edu.au RI ; Johnson, Nathan/Q-3158-2016; Tierney, Audrey/AAB-7068-2022; George, Elena/J-3357-2019 OI Abbott, Gavin/0000-0003-4014-0705; Johnson, Nathan/0000-0002-3874-7092; George, Elena/0000-0002-1385-2371; Roberts, Stuart/0000-0002-9015-7997; Reddy, Anj/0009-0007-3332-8597 FU La Trobe University Research Focus Area `Understanding Disease' grant; Australian Government Research Training Program Scholarship; Almond Board of Australia, Jalna FX This project was funded by a La Trobe University Research Focus Area `Understanding Disease' grant. This work was supported by an Australian Government Research Training Program Scholarship (ESG, AR). Food was donated for study participant hampers from Boundary Bend, Almond Board of Australia, Jalna, HJ Heinz, Simplot and Carmen's, these companies had no input into the trial design or delivery. 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PD JUN PY 2022 VL 42 IS 6 BP 1308 EP 1322 DI 10.1111/liv.15264 EA APR 2022 PG 15 WC Gastroenterology & Hepatology WE Science Citation Index Expanded (SCI-EXPANDED) SC Gastroenterology & Hepatology GA 1Y2MP UT WOS:000787573000001 PM 35357066 OA Green Submitted, hybrid DA 2026-02-02 ER PT J AU Sharpton, SR Schnabl, B Knight, R Loomba, R AF Sharpton, S. R. Schnabl, B. Knight, R. Loomba, R. TI Current Concepts, Opportunities, and Challenges of Gut Microbiome-Based Personalized Medicine in Nonalcoholic Fatty Liver Disease SO CELL METABOLISM LA English DT Review ID CARDIOVASCULAR-DISEASE; FRUCTOSE CONSUMPTION; MEDITERRANEAN DIET; CIRCADIAN CLOCK; FIBROSIS STAGE; LONG-TERM; ADHERENCE; HEALTH; STEATOHEPATITIS; INFLAMMATION AB Nonalcoholic fatty liver disease (NALFD) is now a leading cause of chronic liver disease worldwide, in part, as a consequence of rapidly rising levels of obesity and metabolic syndrome and is a major risk factor for cirrhosis, hepatocellular carcinoma, and liver-related mortality. From NAFLD stems a myriad of clinical challenges related to both diagnosis and management. A growing body of evidence suggests an intricate linkage between the gut microbiome and the pathogenesis of NAFLD. We highlight how our current knowledge of the gut-liver axis in NAFLD may be leveraged to develop gut microbiome-based personalized approaches for disease management, including its use as a non-invasive biomarker for diagnosis and staging, as a target for therapeutic modulation, and as a marker of drug response. We will also discuss current limitations of these microbiome-based approaches. Ultimately, a better understanding of microbiota-host interactions in NAFLD will inform the development of novel preventative strategies and precise therapeutic targets. C1 [Sharpton, S. R.; Schnabl, B.; Loomba, R.] Univ Calif San Diego, Dept Med, Div Gastroenterol, La Jolla, CA 92093 USA. [Sharpton, S. R.; Loomba, R.] Univ Calif San Diego, Div Gastroenterol, NAFLD Res Ctr, La Jolla, CA 92093 USA. [Schnabl, B.] VA San Diego Healthcare Syst, Dept Med, San Diego, CA USA. [Schnabl, B.; Knight, R.; Loomba, R.] Univ Calif San Diego, Ctr Microbiome Innovat, San Diego, CA 92103 USA. [Knight, R.] Univ Calif San Diego, Dept Comp Sci & Engn, Jacobs Sch Engn, La Jolla, CA 92093 USA. [Knight, R.] Univ Calif San Diego, Dept Bioengn, Jacobs Sch Engn, La Jolla, CA 92093 USA. [Knight, R.] Univ Calif San Diego, Dept Pediat, La Jolla, CA 92093 USA. C3 University of California System; University of California San Diego; University of California System; University of California San Diego; US Department of Veterans Affairs; Veterans Health Administration (VHA); VA San Diego Healthcare System; University of California System; University of California San Diego; University of California System; University of California San Diego; University of California System; University of California San Diego; University of California System; University of California San Diego RP Loomba, R (通讯作者)，Univ Calif San Diego, Dept Med, Div Gastroenterol, La Jolla, CA 92093 USA.; Loomba, R (通讯作者)，Univ Calif San Diego, Div Gastroenterol, NAFLD Res Ctr, La Jolla, CA 92093 USA.; Loomba, R (通讯作者)，Univ Calif San Diego, Ctr Microbiome Innovat, San Diego, CA 92103 USA. EM roloomba@ucsd.edu RI Schnabl, Bernd/HCH-3471-2022; Loomba, Rohit/AAE-7831-2019; Knight, Rob/D-1299-2010 OI Sharpton, Suzanne/0000-0001-7722-5716; Knight, Rob/0000-0002-0975-9019 FU Advanced/Transplant Hepatology Award; Alan Hofmann Clinical, Translational, and Outcomes Research Award from the American Association for the Study of Liver Diseases (AASLD) Foundation; NIEHS [5P42ES010337]; NCATS [5UL1TR001442]; NIDDK [R01DK106419, P30DK120515, P30 DK120515]; DOD PRCRP [CA170674P2]; National Center for Advancing Translational Sciences [UL1TR001442] Funding Source: NIH RePORTER; National Institute of Diabetes and Digestive and Kidney Diseases [P30DK120515] Funding Source: NIH RePORTER; National Institute of Environmental Health Sciences [P42ES010337] Funding Source: NIH RePORTER; CDMRP [CA170674P2, 1100671] Funding Source: Federal RePORTER FX S.S. receives grant support from the Advanced/Transplant Hepatology Award and the Alan Hofmann Clinical, Translational, and Outcomes Research Award from the American Association for the Study of Liver Diseases (AASLD) Foundation. R.L. receives funding support from NIEHS (5P42ES010337), NCATS (5UL1TR001442), NIDDK (R01DK106419, P30DK120515), and DOD PRCRP (CA170674P2). This review was supported by the NIDDK-funded San Diego Digestive Diseases Research Center (P30 DK120515). 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129 TC 150 Z9 164 U1 4 U2 105 PU CELL PRESS PI CAMBRIDGE PA 50 HAMPSHIRE ST, FLOOR 5, CAMBRIDGE, MA 02139 USA SN 1550-4131 EI 1932-7420 J9 CELL METAB JI Cell Metab. PD JAN 5 PY 2021 VL 33 IS 1 BP 21 EP 32 DI 10.1016/j.cmet.2020.11.010 EA JAN 2021 PG 12 WC Cell Biology; Endocrinology & Metabolism WE Science Citation Index Expanded (SCI-EXPANDED) SC Cell Biology; Endocrinology & Metabolism GA RB3AI UT WOS:000631986100006 PM 33296678 OA Green Submitted, Bronze DA 2026-02-02 ER PT J AU Monserrat-Mesquida, M Quetglas-Llabrés, M Bouzas, C Montemayor, S Mascaró, CM Casares, M Llompart, I Gámez, JM Tejada, S Martínez, JA Tur, JA Sureda, A AF Monserrat-Mesquida, Margalida Quetglas-Llabres, Magdalena Bouzas, Cristina Montemayor, Sofia Mascaro, Catalina M. Casares, Miguel Llompart, Isabel Gamez, Jose M. Tejada, Silvia Alfredo Martinez, J. Tur, Josep A. Sureda, Antoni TI A Greater Improvement of Intrahepatic Fat Contents after 6 Months of Lifestyle Intervention Is Related to a Better Oxidative Stress and Inflammatory Status in Non-Alcoholic Fatty Liver Disease SO ANTIOXIDANTS LA English DT Article DE NAFLD; IFC; aerobic capacity; oxidative stress; inflammation; biomarkers ID METABOLIC SYNDROME; WEIGHT-LOSS; LONG-TERM; MEDITERRANEAN DIET; HEPATIC STEATOSIS; PHYSICAL-ACTIVITY; NAFLD; PATHOGENESIS; PROGRESSION; STEATOHEPATITIS AB Non-alcoholic fatty liver disease (NAFLD) is a disorder characterized by the excessive accumulation of lipids in the liver parenchyma. To date, there is no effective pharmacological treatment against NAFLD. Objective: To assess the relationship between the improvement of the intrahepatic fat content (IFC) in patients with NAFLD and metabolic syndrome and biomarkers of oxidative stress and inflammation after 6 months of lifestyle intervention. Patients diagnosed with NAFLD (n = 60 adults; 40-60 years old) residing in the Balearic Islands, Spain, were distributed in tertiles attending the improvement of IFC calculated by magnetic resonance imaging (MRI). Anthropometrics, blood pressure, maximal oxygen uptake, and pro/antioxidant and inflammatory biomarkers were determined in plasma before and after the lifestyle intervention. The improvement in IFC levels was higher in tertile 3 with respect to tertiles 2 and 1. The greatest improvement in IFC is related to cardiorespiratory fitness and adherence to the Mediterranean diet (ADM). Higher reductions in weight, body mass index (BMI), and alanine aminotransferase (ALT) were observed in tertile 3 with respect to tertile 1 after 6 months of intervention. The improvement in catalase, irisin, and cytokeratin 18 plasma levels were higher in tertile 3, whereas no differences were observed in superoxide dismutase activity. Malondialdehyde and protein carbonyl levels, as biomarkers of oxidative damage, remained unchanged in all groups. The present data show that the reduction of IFC is associated with an improvement in pro/antioxidant and pro-inflammatory status and a better cardiorespiratory fitness in NAFLD patients. C1 [Monserrat-Mesquida, Margalida; Quetglas-Llabres, Magdalena; Bouzas, Cristina; Montemayor, Sofia; Mascaro, Catalina M.; Llompart, Isabel; Gamez, Jose M.; Tejada, Silvia; Tur, Josep A.; Sureda, Antoni] Univ Balearic Isl IUNICS, Res Grp Community Nutr & Oxidat Stress, Palma De Mallorca 07122, Spain. [Monserrat-Mesquida, Margalida; Quetglas-Llabres, Magdalena; Bouzas, Cristina; Llompart, Isabel; Gamez, Jose M.; Tejada, Silvia; Tur, Josep A.; Sureda, Antoni] Hlth Res Inst Balearic Isl IdISBa, Palma De Mallorca 07120, Spain. [Monserrat-Mesquida, Margalida; Bouzas, Cristina; Montemayor, Sofia; Mascaro, Catalina M.; Llompart, Isabel; Tejada, Silvia; Tur, Josep A.; Sureda, Antoni] Inst Salud Carlos III ISCIII, CIBER Fisiopatol Obesidad & Nutr CIBEROBN, Madrid 28029, Spain. [Casares, Miguel] Red Asistencial Juaneda, Radiodiag Serv, Palma De Mallorca 07011, Spain. [Llompart, Isabel] Univ Hosp Son Espases, Clin Anal Serv, Palma De Mallorca 07198, Spain. [Gamez, Jose M.] Univ Hosp Son Llatzer, Cardiol Serv, Palma De Mallorca 07010, Spain. [Tejada, Silvia] Univ Balearic Isl, Dept Biol, Lab Neurophysiol, Palma De Mallorca 07122, Spain. [Alfredo Martinez, J.] Inst Madrileno Estudios Avanzados Alimentac IMDEA, Cardiomet Precis Nutr Program, Madrid 28049, Spain. C3 Institut Investigacio Sanitaria Illes Balears (IdISBa); CIBER - Centro de Investigacion Biomedica en Red; CIBEROBN; Hospital Universitari Son Espases; Hospital Universitari Son Llatzer; Universitat de les Illes Balears RP Tur, JA (通讯作者)，Univ Balearic Isl IUNICS, Res Grp Community Nutr & Oxidat Stress, Palma De Mallorca 07122, Spain.; Tur, JA (通讯作者)，Hlth Res Inst Balearic Isl IdISBa, Palma De Mallorca 07120, Spain.; Tur, JA (通讯作者)，Inst Salud Carlos III ISCIII, CIBER Fisiopatol Obesidad & Nutr CIBEROBN, Madrid 28029, Spain. EM margalida.monserrat@uib.es; m.quetglas@uib.es; cristinabouzas@uib.es; sofiamf16@gmail.com; c.mascaro@uib.es; casaresmiguel@gmail.com; isabel.llompart@ssib.es; jmgamez@hsll.es; silvia.tejada@uib.es; jalfredo.martinez@imdea.org; pep.tur@uib.es; antoni.sureda@uib.es RI Sureda, Antoni/N-9588-2019; Tur, Josep/AAE-5748-2020; Tejada, Silvia/L-7297-2014; Monserrat Mesquida, Margalida/AAB-4773-2019; Quetglas Llabrés, Maria Magdalena/AAA-4412-2019; Bouzas, Cristina/AAE-2069-2019 OI Tur, Josep/0000-0002-6940-0761; , Antoni/0000-0001-8656-6838; Monserrat Mesquida, Margalida/0000-0002-8856-135X; Quetglas Llabrés, Maria Magdalena/0000-0003-4155-7780; Montemayor, Sofía/0000-0001-7833-2118; Bouzas Velasco, Cristina/0000-0002-1407-8461 FU Fundacio La Marato TV3 (Spain) [201630.10]; Instituto de Salud Carlos III through the Fondo de Investigacion para la Salud [CIBEROBN CB12/03/30038, CIBER OBN18PI03]; European Regional Development Fund; EU-COST Action [CA16112]; IDISBA Grant (FOLIUM); Spanish Ministry of Education; IDISBA grant; IDISBA Grant (PRIMUS); IDISBA Grant (SYNERGIA); IDISBA Grant (LIBERI) FX Fundacio La Marato TV3 (Spain) project ref. 201630.10. Instituto de Salud Carlos III through the Fondo de Investigacion para la Salud (CIBEROBN CB12/03/30038 and Proyecto Intramural CIBER OBN18PI03), which are co-funded by the European Regional Development Fund. Other funding received: EU-COST Action CA16112 and IDISBA Grants (FOLIUM, PRIMUS, SYNERGIA, and LIBERI). M.Q.-L. was granted by IDISBA grant. C.M.M. received an FPU Ph.D. Grant from the Spanish Ministry of Education. The funding sponsors had no role in the design of the study, in the collection, analyses, or interpretation of the data; in the writing of the manuscript, or in the decision to publish the results. 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Bouzas, Cristina Montemayor, Sofia Casares, Miguel Llompart, Isabel Ugarriza, Lucia Borras, Pere-Antoni Martinez, J. Alfredo Tur, Josep A. TI Effect of a Six-Month Lifestyle Intervention on the Physical Activity and Fitness Status of Adults with NAFLD and Metabolic Syndrome SO NUTRIENTS LA English DT Article DE physical activity; Mediterranean diet; non-alcoholic fatty liver disease; metabolic syndrome; fitness ID FATTY LIVER-DISEASE; ACTIVITY QUESTIONNAIRE; TIME; DIET; ASSOCIATION; VALIDATION; DIAGNOSIS; STRENGTH AB (1) Background: Physical inactivity has been linked to NAFLD, and exercise has been reported as useful to reduce intrahepatic fat content in NAFLD. (2) Objectives: To assess the physical activity (PA) and fitness status after a six-month lifestyle intervention (diet and PA) in adults with NAFLD and metabolic syndrome (MetS). (3) Design: Prospective cohort analysis of data obtained between baseline and six-year parallel-group randomized trial (n = 155, aged 40-60 years old, with MetS and NAFLD). Participants were randomized into three nutritional and PA intervention groups: Conventional diet (CD); MedDiet-high meal frequency (MD-HMF); MedDiet-physical activity (MD-PA). (4) Methods: PA and fitness status were assessed using a validated Minnesota questionnaire, ALPHA-FIT test battery, accelerometers, and functional fitness score. Information related to age, gender, education level, marital status, socioeconomic status, smoking habit, and alcohol consumption were also obtained. (5) Results: The CD group had higher improvement in standing handgrip than the MD-HMF group. The MD-PA group did more modified push-up repetitions than the CD group. The MD-PA and CD groups showed higher sitting handgrip than the MD-HMF group. The MD-HMF group showed the highest decrease in aerobic capacity. The MD-PA group showed lower light intensity PA/day than the CD and MD-HMF groups. The MD-PA group showed higher moderate intensity PA than the CD and MD-HMF groups. The CD group reported more METs per day than the MD-HMF group. (6) Conclusions: Lifestyle six-month intervention with diet and regular PA improved functional fitness in middle-aged patients with NAFLD and MetS. Aerobic capacity improved in patients who followed a Mediterranean diet and regular training sessions at six months. C1 [Mascaro, Catalina M.; Bouzas, Cristina; Montemayor, Sofia; Llompart, Isabel; Ugarriza, Lucia; Tur, Josep A.] Univ Balearic Islands IUNICS Islands IUNICS, Res Grp Community Nutr & Oxidat Stress, Palma De Mallorca 07122, Spain. [Mascaro, Catalina M.; Bouzas, Cristina; Montemayor, Sofia; Llompart, Isabel; Ugarriza, Lucia; Tur, Josep A.] Hlth Inst Balearic Islands IDISBA, Palma De Mallorca 07120, Spain. [Bouzas, Cristina; Tur, Josep A.] Inst Salud Carlos III ISCIII, CIBEROBN Physiopathol Obes & Nutr CB12 03 30038, Madrid 28029, Spain. [Casares, Miguel] Red Asistencial Juaneda, Radiodiag Serv, Palma De Mallorca 07011, Spain. [Llompart, Isabel] Univ Hosp Son Espases, Clin Anal Serv, Palma De Mallorca 07120, Spain. [Ugarriza, Lucia] Camp Redo Primary Hlth Care Ctr, Palma De Mallorca 07010, Spain. [Borras, Pere-Antoni] Univ Balearic Islands, Dept Pedag & Specif Didact, Area Phys Educ & Sports, Palma De Mallorca 07122, Spain. [Martinez, J. Alfredo] CEI UAM CSIC, IMDEA Food, Cardiometabol Precis Nutr Program, Madrid 28049, Spain. [Martinez, J. Alfredo] Univ Navarra, Dept Nutr Food Sci & Physiol, Pamplona 31008, Spain. C3 CIBER - Centro de Investigacion Biomedica en Red; CIBEROBN; Hospital Universitari Son Espases; Consejo Superior de Investigaciones Cientificas (CSIC); IMDEA Food Institute; University of Navarra RP Tur, JA (通讯作者)，Univ Balearic Islands IUNICS Islands IUNICS, Res Grp Community Nutr & Oxidat Stress, Palma De Mallorca 07122, Spain.; Tur, JA (通讯作者)，Hlth Inst Balearic Islands IDISBA, Palma De Mallorca 07120, Spain.; Tur, JA (通讯作者)，Inst Salud Carlos III ISCIII, CIBEROBN Physiopathol Obes & Nutr CB12 03 30038, Madrid 28029, Spain. EM c.mascaro@uib.es; cristina.bouzas@uib.es; sofiamf16@gmail.com; casaresmiguel@gmail.com; isabel.llompart@ssib.es; luciaugarriza@gmail.com; pa-borras@uib.es; jalfredo.martinez@imdea.org; pep.tur@uib.es RI Martínez, J./K-8709-2014; BORRAS, PERE A/H-2403-2013; Bouzas, Cristina/AAE-2069-2019; Tur, Josep/AAE-5748-2020 OI BORRAS, PERE A/0000-0001-6793-7592; Bouzas Velasco, Cristina/0000-0002-1407-8461; Tur, Josep/0000-0002-6940-0761 FU Fundacio La Marato TV3 (Spain) project [201630.10]; Instituto de Salud Carlos III - European Regional Development Fund [CIBEROBN CB12/03/30038, CIBER OBN18PI03]; IDISBA Grant (FOLIUM); IDISBA Grant (PRIMUS); IDISBA Grant (SYNERGIA); IDISBA Grant (LIBERI); Spanish Ministry of Education FX Fundacio La Marato TV3 (Spain) project ref. 201630.10. Instituto de Salud Carlos III through the CIBEROBN CB12/03/30038, and Proyecto Intramural CIBER OBN18PI03, which are co-funded by the European Regional Development Fund. Other funding received: IDISBA Grants (FOLIUM, PRIMUS, SYNERGIA, and LIBERI). Catalina M. Mascaro received an FPU PhD Grant from the Spanish Ministry of Education. The funding sponsors had no role in the design of the study, in the collection, analyses, or interpretation of the data; in the writing of the manuscript, or in the decision to publish the results. CR Abbate M, 2021, NUTRIENTS, V13, DOI 10.3390/nu13020629 Abd El-Kader SM, 2015, WORLD J HEPATOL, V7, P846, DOI 10.4254/wjh.v7.i6.846 Abenavoli L, 2017, NUTRIENTS, V9, DOI 10.3390/nu9080870 [Anonymous], 2020, PREVENTION REVERSION [Anonymous], IDF CONS WORLDW DEF Anstee QM, 2013, NAT REV GASTRO HEPAT, V10, P330, DOI 10.1038/nrgastro.2013.41 Bennett H, 2016, SPORTS MED, V46, P737, DOI 10.1007/s40279-015-0445-1 Chalasani N, 2018, HEPATOLOGY, V67, P328, DOI [10.1002/hep.29367, 10.1038/s42255-021-00344-4] Cho J, 2021, INT J ENV RES PUB HE, V18, DOI 10.3390/ijerph18041892 de la Iglesia R, 2014, BRIT J NUTR, V111, P643, DOI 10.1017/S0007114513002778 ELOSUA R, 1994, AM J EPIDEMIOL, V139, P1197, DOI 10.1093/oxfordjournals.aje.a116966 Elosua R, 2000, MED SCI SPORT EXER, V32, P1431, DOI 10.1097/00005768-200008000-00011 Estruch R, 2018, NEW ENGL J MED, V378, DOI [10.1056/NEJMoa1200303, 10.1056/NEJMoa1800389, 10.1056/nejmoa1800389] Fabbrini E, 2010, HEPATOLOGY, V51, P679, DOI 10.1002/hep.23280 Füzéki E, 2017, SPORTS MED, V47, P1769, DOI 10.1007/s40279-017-0724-0 Issa D, 2018, LIVER INT, V38, P56, DOI 10.1111/liv.13676 Jeznach-Steinhagen A, 2019, MEDICINA-LITHUANIA, V55, DOI 10.3390/medicina55050166 Kneeman JM, 2012, THER ADV GASTROENTER, V5, P199, DOI 10.1177/1756283X11430859 Martínez-González MA, 2015, PROG CARDIOVASC DIS, V58, P50, DOI 10.1016/j.pcad.2015.04.003 Mascaro CM, 2022, NUTRIENTS, V14, DOI 10.3390/nu14010049 Morris M, 2019, OCCUP MED-OXFORD, V69, P133, DOI 10.1093/occmed/kqz014 RICHARDSON MT, 1994, J CLIN EPIDEMIOL, V47, P271, DOI 10.1016/0895-4356(94)90008-6 Romero-Gómez M, 2017, J HEPATOL, V67, P829, DOI 10.1016/j.jhep.2017.05.016 Ryu S, 2015, J HEPATOL, V63, P1229, DOI 10.1016/j.jhep.2015.07.010 Saghaei M., 2011, J Biomed Sci Eng, V4, P734, DOI [DOI 10.4236/JBISE.2011.411090, 10.4236/jbise.2011.411090] Sargeant JA, 2018, OBES REV, V19, P1446, DOI 10.1111/obr.12719 Sasaki H, 2007, AM J MED, V120, P337, DOI 10.1016/j.amjmed.2006.04.018 Sherif ZA, 2019, NONALCOHOLIC FATTY L Skender S, 2016, BMC PUBLIC HEALTH, V16, DOI 10.1186/s12889-016-3172-0 Sousa N, 2014, GERIATR GERONTOL INT, V14, P892, DOI 10.1111/ggi.12188 Suni J, 2009, FITNESS HLTH ALPHA F Sykes K., 2016, CARTWRIGHTFITNESS HL Takahashi A, 2015, INT J SPORTS MED, V36, P848, DOI 10.1055/s-0035-1549853 Than NN, 2015, CLIN MED, V15, P186, DOI 10.7861/clinmedicine.15-2-186 Tutino V, 2018, NUTRIENTS, V10, DOI 10.3390/nu10091299 Vernon G, 2011, ALIMENT PHARM THER, V34, P274, DOI 10.1111/j.1365-2036.2011.04724.x Wu T, 2009, OBES REV, V10, P313, DOI 10.1111/j.1467-789X.2008.00547.x NR 37 TC 33 Z9 38 U1 5 U2 17 PU MDPI PI BASEL PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND EI 2072-6643 J9 NUTRIENTS JI Nutrients PD MAY PY 2022 VL 14 IS 9 AR 1813 DI 10.3390/nu14091813 PG 11 WC Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Nutrition & Dietetics GA 1G9OG UT WOS:000796176300001 PM 35565780 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Simpson, SJ Raubenheimer, D Cogger, VC Macia, L Solon-Biet, SM Le Couteur, DG George, J AF Simpson, Stephen J. Raubenheimer, David Cogger, Victoria C. Macia, Laurence Solon-Biet, Samantha M. Le Couteur, David G. George, Jacob TI The nutritional geometry of liver disease including non-alcoholic fatty liver disease SO JOURNAL OF HEPATOLOGY LA English DT Review DE Nutrients; Macronutrients; Fatty liver; Geometric Framework for Nutrition; Protein leverage ID LIFE-STYLE INTERVENTION; PROTEIN-LEVERAGE; DIABETES PREVENTION; WEIGHT-LOSS; MEDITERRANEAN DIET; HEPATIC-INJURY; FOLLOW-UP; VITAMIN-E; MACRONUTRIENTS; STEATOHEPATITIS AB Nutrition has a profound effect on chronic liver disease, especially non-alcoholic fatty liver disease (NAFLD). Most observational studies and clinical trials have focussed on the effects of total energy intake, or the intake of individual macronutrients and certain micronutrients, such as vitamin D, on liver disease. Although these studies have shown the importance of nutrition on hepatic outcomes, there is not yet any unifying framework for understanding the relationship between diet and liver disease. The Geometric Framework for Nutrition (GFN) is an innovative model for designing nutritional experiments or interpreting nutritional data that can determine the effects of nutrients and their interactions on animal behaviour and phenotypes. Recently the GFN has provided insights into the relationship between dietary energy and macronutrients on obesity and ageing in mammals including humans. Mouse studies using the GFN have disentangled the effects of macronutrients on fatty liver and the gut microbiome. The GFN is likely to play a significant role in disentangling the effects of nutrients on liver disease, especially NAFLD, in humans. (C) 2017 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved. C1 [Simpson, Stephen J.; Raubenheimer, David; Cogger, Victoria C.; Macia, Laurence; Solon-Biet, Samantha M.; Le Couteur, David G.] Univ Sydney, Charles Perkins Ctr, Sydney, NSW 2006, Australia. [Raubenheimer, David; Solon-Biet, Samantha M.] Univ Sydney, Sch Life & Environm Sci, Sydney, NSW, Australia. [Cogger, Victoria C.; Le Couteur, David G.] Concord Hosp, Ctr Educ & Res Ageing, Sydney, NSW, Australia. [Cogger, Victoria C.; Le Couteur, David G.] Concord Hosp, ANZAC Res Inst, Sydney, NSW, Australia. [Cogger, Victoria C.; Le Couteur, David G.; George, Jacob] Univ Sydney, Sydney, NSW, Australia. [Macia, Laurence] Univ Sydney, Sch Med Sci, Sydney Med Sch, Sydney, NSW, Australia. [George, Jacob] Westmead Hosp, Westmead Inst Med Res, Storr Liver Ctr, Sydney, NSW, Australia. C3 University of Sydney; University of Sydney; Concord Repatriation General Hospital; University of Sydney; ANZAC Research Institute; Concord Repatriation General Hospital; University of Sydney; University of Sydney; NSW Health; Westmead Hospital; University of Sydney; Westmead Institute for Medical Research RP Simpson, SJ (通讯作者)，Univ Sydney, Charles Perkins Ctr, Sydney, NSW 2006, Australia.; George, J (通讯作者)，Westmead Hosp, Dept Med, Westmead, NSW 2145, Australia. EM stephen.simpson@sydney.edu.au; jacob.george@sydney.edu.au RI Simpson, Stephen J/KZU-8465-2024; George, Jacob/P-1496-2014; Macia, Laurence/D-5983-2016; Solon-Biet, Samantha/R-6551-2017; George, Jacob/P-1496-2014 OI Simpson, Stephen J/0000-0003-0256-7687; Raubenheimer, David/0000-0001-9050-1447; George, Jacob/0000-0002-8421-5476; Macia, Laurence/0000-0003-0835-851X; Solon-Biet, Samantha/0000-0003-0608-958X; George, Jacob/0000-0002-6592-3215 FU National Health and Medical Research Council (NHMRC) of Australia; Australian Research Council (ARC) FX National Health and Medical Research Council (NHMRC) of Australia, Australian Research Council (ARC). 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Hepatol. PD FEB PY 2018 VL 68 IS 2 BP 316 EP 325 DI 10.1016/j.jhep.2017.10.005 PG 10 WC Gastroenterology & Hepatology WE Science Citation Index Expanded (SCI-EXPANDED) SC Gastroenterology & Hepatology GA FU6KU UT WOS:000423962300009 PM 29122389 DA 2026-02-02 ER PT J AU Romero-Gómez, M Aller, R Martín-Bermudo, F AF Romero-Gomez, Manuel Aller, Rocio Martin-Bermudo, Franz TI Dietary Recommendations for the Management of Non-alcoholic Fatty Liver Disease (NAFLD): A Nutritional Geometry Perspective SO SEMINARS IN LIVER DISEASE LA English DT Review DE dietary recommendations; geometry of nutrition; food intake; Mediterranean diet ID RANDOMIZED CONTROLLED-TRIAL; INSULIN SENSITIVITY; WEIGHT-LOSS; CONFERS SUSCEPTIBILITY; HISTOLOGICAL SEVERITY; GENETIC-VARIATION; FOOD-CONSUMPTION; PROTEIN-LEVERAGE; SATURATED FAT; ENERGY-INTAKE AB Diet could be both culprit and solution of NAFLD. Dietary modifications have been associated with histological features improvement in NAFLD. The Western diet was related to a greater risk of disease progression while the Mediterranean diet (MD) could promote regression of histological lesions. Modifications in the nutrient composition seems to have lesser impact on NAFLD than dietary modifications. An intrinsic interaction between nutrients in the diet support a specific effect not seen when added separately. Dietary modifications should focus on promoting weight loss but also look for patterns that are able to promote histological improvement. Although several micronutrients' deficit has been related to NAFLD progression, prescribing these micronutrients' supplementation did not reach a positive impact. However, an enriching diet with specific nutrients could be useful, like olive oil supplemented in MD. Geometry of nutrition defines a framework to better understand the interaction between nutrients, foods, and dietetic pattern in the model of diseases and how we could approach taking into consideration the interaction between meals and disease features. After analyzing baseline diet and histological lesions, we could calculate the distance to optimal diet and to promote changes in lifestyle to reach all these goals. A standard MD menu would be recommended. C1 [Romero-Gomez, Manuel] Univ Seville, Hosp Univ Virgen del Rocio, Inst Biomed Sevilla HUVR CSIC US, Dept Med,Digest Dis Unit,SeLiver Grp, Seville, Spain. [Romero-Gomez, Manuel] Ctr Invest Biomed Red Enfermedades Hepat & Digest, Madrid, Spain. [Aller, Rocio] Univ Valladolid, Hosp Clin Valladolid, Ctr Invest Biomedoca Red Enfermedades Infecciosas, Ctr Invest Endocrinol & Nutr,Fac Med,Gastroentero, Valladolid, Spain. [Martin-Bermudo, Franz] Univ Seville, Univ Pablo de Olavide, Ctr Andaluz Biol Mol & Med Regenerat CABIMER, CSIC, Seville, Spain. [Martin-Bermudo, Franz] Ctr Invest Biomed Red Diabet & Enfermedades Metab, Madrid, Spain. C3 University of Sevilla; Virgen del Rocio University Hospital; CIBER - Centro de Investigacion Biomedica en Red; CIBEREHD; Universidad de Valladolid; Consejo Superior de Investigaciones Cientificas (CSIC); Universidad Pablo de Olavide; University of Sevilla; CSIC - Centro Andaluz de Biologia Molecular y Medicina Regenerativa (CABIMER); CIBER - Centro de Investigacion Biomedica en Red; CIBERDEM RP Romero-Gómez, M (通讯作者)，Hosp Univ Virgen del Rocio, Hosp Gen, Planta Baja, Digest Dis Unit, Avda Manuel Siurot S-N, Seville 41013, Spain. EM mromerogomez@us.es RI Martin, Franz/K-4197-2014; ALLER, ROCIO/JXM-2497-2024; Romero-Gomez, Manuel/L-8030-2014 OI Martin, Franz/0000-0002-5745-8704; FU ISCIII [PI19/00589]; Junta de Andalucia [UPO-1380683, GLD1900025] FX This study was supported by grants from ISCIII PI19/00589, PMP21/00078, and Junta de Andalucia P20_01075 and PYC20 RE010 USE to M.R.-G.; grants from Junta de Andalucia (UPO-1380683) to F.M. and GLD1900025 by Gilead-AEEH to R.A. 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Lifestyle modifications with diet and exercise have been the initial management recommendation. However, these changes are difficult to achieve and sustain overtime. There are pharmacologic agents being considered for treatment of NASH. Some target insulin resistance and others focus. on oxidative stress, inflammation, apoptosis, and fibrosis. There is a great deal of effort to develop therapeutic regimens for patients with NASH and NASH with significant fibrosis. C1 [Golabi, Pegah; Bush, Haley; Younossi, Zobair M.] Inova Fairfax Hosp, Inova Hlth Syst, Betty & Guy Beatty Ctr Integrated Res, Claude Moore Hlth Educ & Res Bldg,3rd Floor, Falls Church, VA 22042 USA. [Younossi, Zobair M.] Inova Fairfax Hosp, Ctr Liver Dis, Dept Med, Claude Moore Hlth Educ & Res Bldg,3rd Floor, Falls Church, VA 22042 USA. C3 Inova Fairfax Hospital; Inova Health System; Inova Fairfax Hospital RP Younossi, ZM (通讯作者)，Inova Fairfax Hosp, Inova Hlth Syst, Betty & Guy Beatty Ctr Integrated Res, Claude Moore Hlth Educ & Res Bldg,3rd Floor, Falls Church, VA 22042 USA.; Younossi, ZM (通讯作者)，Inova Fairfax Hosp, Ctr Liver Dis, Dept Med, Claude Moore Hlth Educ & Res Bldg,3rd Floor, Falls Church, VA 22042 USA. 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Liver Dis. PD NOV PY 2017 VL 21 IS 4 BP 739 EP 753 DI 10.1016/j.cld.2017.06.010 PG 15 WC Gastroenterology & Hepatology WE Science Citation Index Expanded (SCI-EXPANDED) SC Gastroenterology & Hepatology GA FL6UX UT WOS:000414382800009 PM 28987260 DA 2026-02-02 ER PT J AU Properzi, C O'Sullivan, TA Sherriff, JL Ching, HL Jeffrey, GP Buckley, RF Tibballs, J MacQuillan, GC Garas, G Adams, LA AF Properzi, Catherine O'Sullivan, Therese A. Sherriff, Jill L. Ching, Helena L. Jeffrey, Garry P. Buckley, Rachel F. Tibballs, Jonathan MacQuillan, Gerry C. Garas, George Adams, Leon A. TI Ad Libitum Mediterranean and Low-Fat Diets Both Significantly Reduce Hepatic Steatosis: A Randomized Controlled Trial SO HEPATOLOGY LA English DT Article ID LIVER-DISEASE; CARDIOVASCULAR-DISEASE; ARTERIAL STIFFNESS; PRIMARY PREVENTION; WEIGHT-LOSS; RELIABILITY; PREVALENCE; HEALTH AB Although diet-induced weight loss is first-line treatment for patients with nonalcoholic fatty liver disease (NAFLD), long-term maintenance is difficult. The optimal diet for improvement in either NAFLD or associated cardiometabolic risk factors, regardless of weight loss, is unknown. We examined the effect of two ad libitum isocaloric diets (Mediterranean [MD] or low fat [LF]) on hepatic steatosis (HS) and cardiometabolic risk factors. Subjects with NAFLD were randomized to a 12-week blinded dietary intervention (MD vs. LF). HS was determined by magnetic resonance spectroscopy (MRS). From a total of 56 subjects enrolled, 49 completed the intervention and 48 were included for analysis. During the intervention, subjects on the MD had significantly higher total and monounsaturated fat, but lower carbohydrate and sodium, intakes compared to LF subjects (P < 0.01). At week 12, HS had reduced significantly in both groups (P < 0.01), and there was no difference in liver fat reduction between groups (P = 0.32), with mean (SD) relative reductions of 25.0% (+/- 25.3%) in LF and 32.4% (+/- 25.5%) in MD. Liver enzymes also improved significantly in both groups. Weight loss was minimal and not different between groups (-1.6 [+/- 2.1] kg in LF vs -2.1 [+/- 2.5] kg in MD; P = 0.52). Within-group improvements in Framingham Risk Score (FRS), total cholesterol, serum triglyceride (TG), and glycated hemoglobin (HbA1c) were observed in the MD (all P < 0.05), but not with the LF diet. Adherence was higher for the MD compared to LF (88% vs. 64%; P = 0.048). Conclusion: Ad libitum low-fat and Mediterranean diets both improve HS to a similar degree. C1 [Properzi, Catherine; O'Sullivan, Therese A.] Edith Cowan Univ, Sch Med & Hlth Sci, Joondalup, Australia. [Sherriff, Jill L.] Curtin Univ, Curtin Hlth Innovat Res Inst, Sch Publ Hlth, Bentley, WA, Australia. [Ching, Helena L.; Jeffrey, Garry P.; MacQuillan, Gerry C.; Garas, George; Adams, Leon A.] Univ Western Australia, Sch Med, Nedlands, WA, Australia. [Ching, Helena L.; Jeffrey, Garry P.; MacQuillan, Gerry C.; Garas, George; Adams, Leon A.] Sir Charles Gairdner Hosp, Dept Hepatol, Nedlands, WA, Australia. [Tibballs, Jonathan] Sir Charles Gairdner Hosp, Dept Radiol, Nedlands, WA, Australia. [Buckley, Rachel F.] Massachusetts Gen Hosp, Dept Neurol, Boston, MA 02114 USA. [Buckley, Rachel F.] Harvard Med Sch, Boston, MA USA. [Buckley, Rachel F.] Univ Melbourne, Florey Inst Neurosci & Mental Hlth, Parkville, Vic, Australia. [Buckley, Rachel F.] Univ Melbourne, Melbourne Sch Psychol Sci, Parkville, Vic, Australia. C3 Edith Cowan University; Curtin University; University of Western Australia; University of Western Australia; Sir Charles Gairdner Hospital; Sir Charles Gairdner Hospital; University of Western Australia; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard Medical School; University of Melbourne; Florey Institute of Neuroscience & Mental Health; University of Melbourne RP Adams, LA (通讯作者)，Univ Western Australia, Sch Med, QEII Med Ctr, M503,6 Verdun St, Nedlands, WA 6009, Australia. EM leon.adams@uwa.edu.au RI O'Sullivan, Therese/D-1723-2016; Properzi, Catherine/JQJ-3932-2023 CR Adams LA, 2005, GASTROENTEROLOGY, V129, P113, DOI 10.1053/j.gastro.2005.04.014 Adams LA, 2017, GUT, V66, P1138, DOI 10.1136/gutjnl-2017-313884 Adams LA, 2011, J GASTROEN HEPATOL, V26, P1536, DOI 10.1111/j.1440-1746.2011.06774.x [Anonymous], 2013, Adherence to Long-Term Therapies: Evidence for Action [Anonymous], MD AW Belfort R, 2006, NEW ENGL J MED, V355, P2297, DOI 10.1056/NEJMoa060326 Bjermo H, 2012, AM J CLIN NUTR, V95, P1003, DOI 10.3945/ajcn.111.030114 Bozzetto L, 2012, DIABETES CARE, V35, P1429, DOI 10.2337/dc12-0033 BROWNELL KD, 1995, BEHAV MED, V20, P149, DOI 10.1080/08964289.1995.9933731 Caussy C, 2018, HEPATOLOGY, V68, P763, DOI 10.1002/hep.29797 Chalasani N, 2018, HEPATOLOGY, V67, P328, DOI [10.1002/hep.29367, 10.1038/s42255-021-00344-4] Chong MFF, 2008, AM J CLIN NUTR, V87, P817, DOI 10.1093/ajcn/87.4.817 Collins C., 2017, for the national heart foundation of australia Craig CL, 2003, MED SCI SPORT EXER, V35, P1381, DOI 10.1249/01.MSS.0000078924.61453.FB Dudekula A, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0111808 EASL, 2016, OBESITY FACTS, V9, P65, DOI 10.1159/000443344 Eckel RH, 2014, CIRCULATION, V129, pS76, DOI 10.1161/01.cir.0000437740.48606.d1 Eslamparast T, 2017, NUTRIENTS, V9, DOI 10.3390/nu9080800 Estruch R, 2018, NEW ENGL J MED, V378, DOI [10.1056/NEJMoa1200303, 10.1056/NEJMoa1800389, 10.1056/nejmoa1800389] Estruch R, 2013, NEW ENGL J MED, V368, P1279, DOI 10.1056/NEJMoa1200303 Estruch R, 2006, ANN INTERN MED, V145, P1, DOI 10.7326/0003-4819-145-1-200607040-00004 Federico A, 2016, TRANSL RES, V167, P116, DOI 10.1016/j.trsl.2015.08.002 Gepner Y, 2018, CIRCULATION, V137, P1143, DOI 10.1161/CIRCULATIONAHA.117.030501 Hafekost K, 2013, BMC MED, V11, DOI 10.1186/1741-7015-11-41 Hawthorne G, 1999, QUAL LIFE RES, V8, P209, DOI 10.1023/A:1008815005736 Hernández EA, 2017, J CLIN INVEST, V127, P695, DOI 10.1172/JCI89444 Kabbany MN, 2017, AM J GASTROENTEROL, V112, P581, DOI 10.1038/ajg.2017.5 Kafatos A, 2000, J AM DIET ASSOC, V100, P1487, DOI 10.1016/S0002-8223(00)00416-8 Kirk E, 2009, GASTROENTEROLOGY, V136, P1552, DOI 10.1053/j.gastro.2009.01.048 Laurent S, 2006, EUR HEART J, V27, P2588, DOI 10.1093/eurheartj/ehl254 Lonardo A, 2017, DIGEST LIVER DIS, V49, P471, DOI 10.1016/j.dld.2017.01.147 LONGO R, 1995, JMRI-J MAGN RESON IM, V5, P281, DOI 10.1002/jmri.1880050311 Marfell-Jones M., 2012, ISAK MANUAL INT STAN National Health and Medical Research Council, 2013, EAT HLTH ED GUID INF Patel NS, 2015, CLIN GASTROENTEROL H, V13, P561, DOI 10.1016/j.cgh.2014.08.039 Pownall HJ, 2015, OBESITY, V23, P565, DOI 10.1002/oby.21005 Promrat K, 2010, HEPATOLOGY, V51, P121, DOI 10.1002/hep.23276 Richardson J, 2014, PATIENT, V7, P85, DOI 10.1007/s40271-013-0036-x Rienks J, 2017, NUTRIENTS, V9, DOI 10.3390/nu9040415 Ryan MC, 2013, J HEPATOL, V59, P138, DOI 10.1016/j.jhep.2013.02.012 Sacks FM, 2017, CIRCULATION, V136, pE1, DOI 10.1161/CIR.0000000000000510 Van Horn L, 2016, CIRCULATION, V134, pE505, DOI 10.1161/CIR.0000000000000462 Vilar-Gomez E, 2015, GASTROENTEROLOGY, V149, P367, DOI 10.1053/j.gastro.2015.04.005 Vlachopoulos C, 2010, J AM COLL CARDIOL, V55, P1318, DOI 10.1016/j.jacc.2009.10.061 Younossi ZM, 2016, HEPATOLOGY, V64, P73, DOI 10.1002/hep.28431 Zelber-Sagi S, 2017, LIVER INT, V37, P936, DOI 10.1111/liv.13435 NR 46 TC 176 Z9 180 U1 0 U2 7 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0270-9139 EI 1527-3350 J9 HEPATOLOGY JI Hepatology PD NOV PY 2018 VL 68 IS 5 BP 1741 EP 1754 DI 10.1002/hep.30076 PG 14 WC Gastroenterology & Hepatology WE Science Citation Index Expanded (SCI-EXPANDED) SC Gastroenterology & Hepatology GA GY8BX UT WOS:000448844900009 PM 29729189 DA 2026-02-02 ER PT J AU Chicco, F Magrì, S Cingolani, A Paduano, D Pesenti, M Zara, F Tumbarello, F Urru, E Melis, A Casula, L Fantini, MC Usai, P AF Chicco, Fabio Magri, Salvatore Cingolani, Arianna Paduano, Danilo Pesenti, Mario Zara, Federica Tumbarello, Francesca Urru, Emanuela Melis, Alessandro Casula, Laura Fantini, Massimo Claudio Usai, Paolo TI Multidimensional Impact of Mediterranean Diet on IBD Patients SO INFLAMMATORY BOWEL DISEASES LA English DT Article DE Mediterranean diet; inflammatory bowel disease; quality of life; liver steatosis ID QUALITY-OF-LIFE; INFLAMMATORY-BOWEL-DISEASE; FATTY LIVER-DISEASE; CROHNS-DISEASE; IMMUNE-RESPONSES; OBESITY; ADHERENCE; HOMEOSTASIS; MICROBIOTA AB Background & Aims: Malnutrition with the accumulation of fat tissue and nonalcoholic fatty liver disease (NAFLD) are conditions associated with inflammatory bowel disease (IBD). Visceral fat and NAFLD-related liver dysfunction can both worsen intestinal inflammation. Because the Mediterranean diet (Md) has been shown to ameliorate both obesity and NAFLD, the aim of this study was to analyze the impact of Md on the nutritional state, liver steatosis, clinical disease activity, and quality of life (QoL) in IBD patients. Methods: Patients with IBD, both Crohn's disease (CD) and ulcerative colitis (UC), followed Md for 6 months. Their body mass index (BMI), body tissue composition, liver steatosis and function, serum lipid profile, clinical disease activity, and inflammatory biomarkers (C-reactive protein and fecal calprotectin) were collected at baseline (T0) and compared with those obtained after 6 months (T180) to evaluate the impact of Md. Results: One hundred forty-two IBD patients, 84 UC and 58 CD, followed Md for 6 months. At T180, diet-adherent CD and UC improved BMI (UC -0.42, P = 0.002; CD -0.48, P = 0.032) and waist circumference (UC -1.25 cm, P = 0.037; CD -1.37 cm, P = 0.041). Additionally, the number of patients affected by liver steatosis of any grade was significantly reduced in both groups (UC T0 31 of 84 [36.9%] vs T180 18 of 84 [21.4%], P = 0.0016; CD T0 27 of 58 [46.6%] vs T180 18 of 58 [31.0%], P < 0.001) after dietary intervention. Finally, after 6 months of the diet, fewer UC and CD patients with stable therapy had active disease (UC T0 14 of 59 [23.7%] vs T180 4 of 59 [6.8%], P = 0.004; CD T0 of 51 [17.6%] vs T180 2 of 51 [3.0%], P = 0.011) and elevated inflammatory biomarkers. Mediterranean diet improved QoL in both UC and CD, but neither serum lipid profile nor liver function were modified by the diet. Conclusions: A significant reduction of malnutrition-related parameters and liver steatosis was observed in both CD and UC patients after short-term dietary intervention based on the adoption of Md, and this was associated with a spontaneous improvement of disease activity and inflammatory markers. C1 [Chicco, Fabio; Magri, Salvatore; Cingolani, Arianna; Paduano, Danilo; Pesenti, Mario; Zara, Federica; Tumbarello, Francesca; Urru, Emanuela; Melis, Alessandro; Casula, Laura; Fantini, Massimo Claudio; Usai, Paolo] Univ Cagliari, Dept Med Sci & Publ Hlth, Cagliari, Italy. [Chicco, Fabio; Magri, Salvatore; Cingolani, Arianna; Paduano, Danilo; Pesenti, Mario; Zara, Federica; Tumbarello, Francesca; Urru, Emanuela; Melis, Alessandro; Casula, Laura; Fantini, Massimo Claudio; Usai, Paolo] Presidio Policlin Monserrato, Cagliari, Italy. C3 University of Cagliari; University of Cagliari; Monserrato Polyclinic RP Chicco, F (通讯作者)，Univ Cagliari, Dept Med Sci & Publ Hlth, Cagliari, Italy.; Chicco, F (通讯作者)，Presidio Policlin Monserrato, Cagliari, Italy. 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PD JAN PY 2021 VL 27 IS 1 BP 1 EP 9 DI 10.1093/ibd/izaa097 PG 9 WC Gastroenterology & Hepatology WE Science Citation Index Expanded (SCI-EXPANDED) SC Gastroenterology & Hepatology GA PQ7DG UT WOS:000606702800006 PM 32440680 OA Green Submitted, Bronze HC Y HP N DA 2026-02-02 ER PT J AU Nguyen, V George, J AF Vi Nguyen George, Jacob TI Nonalcoholic Fatty Liver Disease Management: Dietary and Lifestyle Modifications SO SEMINARS IN LIVER DISEASE LA English DT Review DE nonalcoholic fatty liver; nonalcoholic steatohepatitis; lifestyle intervention; dietary modification; macronutrients; exercise ID CORONARY-HEART-DISEASE; ALL-CAUSE MORTALITY; ALANINE AMINOTRANSFERASE LEVELS; IMPAIRED GLUCOSE-TOLERANCE; VIGOROUS PHYSICAL-ACTIVITY; LOW-PROTEIN CONTENT; MEDITERRANEAN DIET; INSULIN-RESISTANCE; VITAMIN-D; CARDIOVASCULAR-DISEASE AB Nonalcoholic fatty liver disease (NAFLD) encompasses a spectrum of abnormalities that can range from bland liver fat (steatosis), to hepatic inflammation and liver injury (steatohepatitis). It is estimated that NAFLD will become the principal cause of liver disease in Western nations and the leading indication for liver transplantation. Advancements in disease recognition and management are therefore paramount. Although the development of new, reliable drug therapies is vital, lifestyle interventions remain the most effective treatment modality. In addition to weight loss as a primary measure of treatment success, there is growing recognition that other endpoints, including the prevention or delay of diabetes onset, reduced cardiovascular events, prevention of cancer, and improved overall mortality, are equally important outcomes that can be independently modified by lifestyle change. Moreover, NAFLD is inextricably part of a complex, systemic disease process that is linked with deeply entrenched maladaptive lifestyle behaviors. Thus, a holistic, multidisciplinary, and individualized approach to disease management will be the key to achieving any realistic population-level change. C1 [Vi Nguyen; George, Jacob] Univ Sydney, Westmead Hosp, Storr Liver Ctr, Sydney, NSW 2006, Australia. [Vi Nguyen; George, Jacob] Univ Sydney, Westmead Hosp, Westmead Millennium Inst, Sydney, NSW 2006, Australia. C3 University of Sydney; NSW Health; Westmead Hospital; University of Sydney; Westmead Institute for Medical Research; NSW Health; Westmead Hospital RP George, J (通讯作者)，Univ Sydney, Westmead Hosp, Storr Liver Ctr, Sydney, NSW 2006, Australia. EM jacob.george@sydney.edu.au RI George, Jacob/P-1496-2014 OI George, Jacob/0000-0002-8421-5476 FU National Health and Medical Research Council of Australia (NHMRC) [1053206]; University of Sydney, Australia; [1006759]; [1047417] FX Jacob George is supported by the Robert W. Storr Bequest to the Sydney Medical Foundation, University of Sydney; a National Health and Medical Research Council of Australia (NHMRC) Program Grant (1053206); and Project Grants 1006759 and 1047417. Vi Nguyen is supported by a Postgraduate Award through The University of Sydney, Australia. 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Liver Dis. PD AUG PY 2015 VL 35 IS 3 BP 318 EP 337 DI 10.1055/s-0035-1562950 PG 20 WC Gastroenterology & Hepatology WE Science Citation Index Expanded (SCI-EXPANDED) SC Gastroenterology & Hepatology GA CR6ZX UT WOS:000361498200010 PM 26378647 DA 2026-02-02 ER PT J AU Barrea, L Di Somma, C Muscogiuri, G Tarantino, G Tenore, GC Orio, F Colao, A Savastano, S AF Barrea, Luigi Di Somma, Carolina Muscogiuri, Giovanna Tarantino, Giovanni Tenore, Gian Carlo Orio, Francesco Colao, Annamaria Savastano, Silvia TI Nutrition, inflammation and liver-spleen axis SO CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION LA English DT Review DE Diet; Inflammation; Liver-spleen Axis; Nutrition; Nutritionist ID NONALCOHOLIC FATTY LIVER; REGULATORY T-CELLS; C-REACTIVE PROTEIN; MEDITERRANEAN DIETARY PATTERN; LOW-GRADE INFLAMMATION; VITAMIN-D STATUS; ADIPOSE-TISSUE; INSULIN-RESISTANCE; METABOLIC SYNDROME; HEPATIC STEATOSIS AB Chronic low-grade systemic inflammation represents a mechanism common to many diseases linked to atherosclerosis-related pathways. There is a growing body of evidence indicating that the combination of food quantity and quality along with genetic susceptibility are able to induce the aberrant activation of innate immune signalling, which initially contributes to chronic low-grade inflammation. Liver represents the central player to inflammatory response. Dietary/metabolic factors contribute to the pathogenesis of Non-alcoholic Fatty Liver Disease (NAFLD), the main causes of liver disease in the Western world. Enlargement of the spleen, central organ in regulating the inflammation-related immune response, is commonly seen in patients with of NAFLD, depicting the so called "liver-spleen axis." The aim of this review was to provide an at-a-glance overview of the possible bi-directional mechanisms linking nutrition and inflammation, particularly pinpointing the inflammatory effects stemmed by nutrition on "liver-spleen axis." In particular, the role of unhealthy diet, healthy dietary patterns, such as the Mediterranean diet style, dietary vitamins and micronutrients, such as vitamin D or Magnesium, and Glucagon-Like Peptide-1, a well-known incretin released in response to meal intake, will be discussed. The highly variability of the inflammatory response highlights the role of expert nutritionists in refining methodologies apt to assess nutritional epidemiology and to apply appropriate dietary intervention to counteract diet-induced inflammation mechanisms. C1 [Barrea, Luigi; Muscogiuri, Giovanna] IOS & COLEMAN Srl, Med Futura Med Ctr, I-80011 Naples, Italy. [Di Somma, Carolina] IRCCS, SDN, Via Gianturco 113, Naples, Italy. [Tarantino, Giovanni; Colao, Annamaria; Savastano, Silvia] Univ Naples Federico II, Med Sch Naples, Dipartimento Med Clin & Chirurg, Via Sergio Pansini 5, Naples, Italy. [Tenore, Gian Carlo] Univ Naples Federico II, Dept Pharm, Via D Montesano 49, Naples, Italy. [Orio, Francesco] Parthenope Univ Naples, Unit Endocrinol, Dept Sports Sci & Wellness, Via Ammiraglio Ferdinando Acton 38, Naples, Italy. [Colao, Annamaria] Via Ammiraglio Ferdinando Acton 38, Naples, Italy. C3 IRCCS Fondazione Pascale; IRCCS Istituto di Ricerca Diagnostica e Nucleare (SDN); University of Naples Federico II; University of Naples Federico II; Parthenope University Naples RP Muscogiuri, G (通讯作者)，IOS & COLEMAN Srl, Med Futura Med Ctr, I-80011 Naples, Italy. 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Rev. Food Sci. Nutr. PD DEC 12 PY 2018 VL 58 IS 18 BP 3141 EP 3158 DI 10.1080/10408398.2017.1353479 PG 18 WC Food Science & Technology; Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Food Science & Technology; Nutrition & Dietetics GA HL5VW UT WOS:000458800200006 PM 28799803 DA 2026-02-02 ER PT J AU Tedesco, CC Bonfiglio, C Notarnicola, M Rendina, M Castellaneta, A Di Leo, A Giannelli, G Fontana, L AF Tedesco, Calogero Claudio Bonfiglio, Caterina Notarnicola, Maria Rendina, Maria Castellaneta, Antonino Di Leo, Alfredo Giannelli, Gianluigi Fontana, Luigi TI High Extra Virgin Olive Oil Consumption Is Linked to a Lower Prevalence of NAFLD with a Prominent Effect in Obese Subjects: Results from the MICOL Study SO NUTRIENTS LA English DT Article DE olive oil; Mediterranean diet; fatty liver; obesity; odds ratio; relative risk reduction ID FATTY LIVER-DISEASE; DIET AB Extra virgin olive oil (EVOO) has healthy benefits for noncommunicable diseases (NCDs). However, limited evidence is available about the effects of liver disease and non-alcoholic fatty liver disease (NAFLD). We evaluate whether dose-increased consumption of EVOO is associated with a lower prevalence of NAFLD and if these effects vary based on body weight. The study included 2436 subjects with a 33% NAFLD prevalence. Daily EVOO was categorized into tertiles: low (0-24 g/day), moderate (25-37 g/day), and high consumption (>37 g/day). Subjects were also classified by body mass index (BMI) as normo-weight (18.5-24.9), overweight (25-29.9), and obese (>= 30). Logistic regression analysis was applied to calculate odds ratios (ORs) for NAFLD, considering a 20-gram increment in EVOO intake and accounting for EVOO categories combined with BMI classes. The ORs were 0.83 (0.74;0.93) C.I. p = 0.0018 for continuous EVOO, 0.89 (0.69;1.15) C.I. p = 0.37, and 0.73 (0.55;0.97) C.I. p = 0.03 for moderate and high consumption, respectively, when compared to low consumption. Overall, the percent relative risk reductions (RRR) for NAFLD from low to high EVOO consumption were 18% (16.4%;19.2%) C.I. and 26% (25%;27.4%) C.I. in overweight and obese subjects. High EVOO consumption is associated with a reduced risk of NAFLD. This effect is amplified in overweight subjects and even more in obese subjects. C1 [Tedesco, Calogero Claudio] IRCCS Saverio de Bellis Res Hosp, Natl Inst Gastroenterol, Data Sci Unit, I-70013 Castellana Grotte, Italy. [Bonfiglio, Caterina] IRCCS Saverio de Bellis Res Hosp, Natl Inst Gastroenterol, Lab Epidemiol & Stat, I-70013 Castellana Grotte, Italy. [Notarnicola, Maria] IRCCS Saverio de Bellis Res Hosp, Natl Inst Gastroenterol, Lab Nutr Biochem, I-70013 Castellana Grotte, Italy. [Rendina, Maria] Policlin Bari, Gastroenterol & Digest Endoscopy, Univ Hosp, I-70100 Bari, Italy. [Castellaneta, Antonino; Di Leo, Alfredo] Univ Bari Aldo Moro, Dept Precis & Regenerat Med & Ionian Area DiMePRe, Gastroenterol Unit, I-70100 Bari, Italy. [Giannelli, Gianluigi] IRCCS Saverio de Bellis Res Hosp, Sci Direct, Natl Inst Gastroenterol, I-70013 Castellana Grotte, Italy. [Fontana, Luigi] Univ Sydney, Fac Med & Hlth, Charles Perkins Ctr, Sydney, NSW 2006, Australia. [Fontana, Luigi] Royal Prince Alfred Hosp, Dept Endocrinol, Sydney, NSW 2006, Australia. C3 Universita degli Studi di Bari Aldo Moro; Universita degli Studi di Bari Aldo Moro; University of Sydney; University of Sydney; NSW Health; Royal Prince Alfred Hospital RP Tedesco, CC (通讯作者)，IRCCS Saverio de Bellis Res Hosp, Natl Inst Gastroenterol, Data Sci Unit, I-70013 Castellana Grotte, Italy. EM calogero.tedesco@irccsdebellis.it; catia.bonfiglio@irccsdebellis.it; maria.notarnicola@irccsdebellis.it; mariarendina@virgilio.it; antocastellaneta@hotmail.com; alfredo.dileo@uniba.it; gianluigi.giannelli@irccsdebellis.it; luigi.fontana@sydney.edu.au RI Fontana, Luigi/K-4773-2013; tedesco, calogero claudio/ABI-1690-2020; Giannelli, Gianluigi/A-8169-2012 OI Fontana, Luigi/0000-0001-8500-5537; tedesco, calogero claudio/0009-0002-6237-078X; Giannelli, Gianluigi/0000-0002-5140-8060; Di Leo, Alfredo/0000-0003-2026-1200; Bonfiglio, Caterina/0000-0002-8650-348X; Notarnicola, Maria/0000-0003-2274-2198 FU Italian Ministry of Health, Ricerca Corrente 2023 FX The study was funded by the Italian Ministry of Health, Ricerca Corrente 2023. 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C3 University of Illinois System; University of Illinois Urbana-Champaign; Northwestern University; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign RP Madak-Erdogan, Z (通讯作者)，Univ Illinois, Dept Food Sci & Human Nutr, Urbana, IL 61801 USA. 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Endocrinology & Metabolism GA IQ5P0 UT WOS:001167810200001 PM 37923152 DA 2026-02-02 ER PT J AU Spiezia, C Di Rosa, C Fintini, D Ferrara, P De Gara, L Khazrai, YM AF Spiezia, Chiara Di Rosa, Claudia Fintini, Danilo Ferrara, Pietro De Gara, Laura Khazrai, Yeganeh Manon TI Nutritional Approaches in Children with Overweight or Obesity and Hepatic Steatosis SO NUTRIENTS LA English DT Review DE NAFLD; childhood and steatosis; childhood obesity ID NONALCOHOLIC FATTY LIVER; CARDIOVASCULAR RISK-FACTORS; LIFE-STYLE INTERVENTIONS; VITAMIN-D DEFICIENCY; BODY-MASS INDEX; MEDITERRANEAN DIET; METABOLIC SYNDROME; OXIDATIVE STRESS; GUT MICROBIOTA; DOCOSAHEXAENOIC ACID AB Childhood obesity is a global public health problem. Worldwide, 41 million children under 5 years and 340 million children and adolescents between 5 and 19 years are overweight. In addition, the recent COVID-19 epidemic has further amplified this social phenomenon. Obesity is a condition associated with various comorbidities, such as nonalcoholic fatty liver disease (NAFLD). The pathophysiology of NAFLD in obesity is intricate and involves the interaction and dysregulation of several mechanisms, such as insulin resistance, cytokine signaling, and alteration of the gut microbiota. NAFLD is defined as the presence of hepatic steatosis in more than 5% of hepatocytes, evaluated by histological analysis. It can evolve from hepatic steatosis to steatohepatitis, fibrosis, cirrhosis, hepatocellular carcinoma, and end-stage liver failure. Body weight reduction through lifestyle modification remains the first-line intervention for the management of pediatric NAFLD. Indeed, studies suggest that diets low in fat and sugar and conversely rich in dietary fibers promote the improvement of metabolic parameters. This review aims to evaluate the existing relationship between obesity and NAFLD in the pediatric population and to assess the dietary patterns and nutritional supplementations that can be recommended to prevent and manage obesity and its comorbidities. C1 [Spiezia, Chiara; Di Rosa, Claudia; De Gara, Laura; Khazrai, Yeganeh Manon] Univ Campus Biomed Roma, Dept Sci & Technol Sustainable Dev & Hlth 1, Res Unit Food Sci & Human Nutr, Via Alvaro Portillo 21, I-00128 Rome, Italy. [Fintini, Danilo] Bambino Gesu Pediat Hosp, Endocrinol & Diabetol Unit, IRCCS Lgo S Onofrio, I-00165 Rome, Italy. [Ferrara, Pietro] Fdn Policlin Univ Campus Biomed, Dept Med & Surg, Operat Res Unit Pediat, Via Alvaro Portillo, 200, I-00128 Rome, Italy. [Khazrai, Yeganeh Manon] Fdn Policlin Univ Campus Biomed, Operat Res Unit Nutr & Prevent, Via Alvaro Portillo, 200, I-00128 Rome, Italy. C3 University Campus Bio-Medico - Rome Italy; IRCCS Bambino Gesu; Fondazione Policlinico Universitario Campus Bio-Medico; Fondazione Policlinico Universitario Campus Bio-Medico RP Di Rosa, C (通讯作者)，Univ Campus Biomed Roma, Dept Sci & Technol Sustainable Dev & Hlth 1, Res Unit Food Sci & Human Nutr, Via Alvaro Portillo 21, I-00128 Rome, Italy. 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WOS:001004715200001 PM 37299398 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Maiuolo, J Mollace, R Bosco, F Scarano, F Oppedisano, F Nucera, S Ruga, S Guarnieri, L Macri, R Bava, I Carresi, C Gliozzi, M Musolino, V Cardamone, A Coppoletta, AR Barillaro, A Simari, V Salvemini, D Palma, E Mollace, V AF Maiuolo, Jessica Mollace, Rocco Bosco, Francesca Scarano, Federica Oppedisano, Francesca Nucera, Saverio Ruga, Stefano Guarnieri, Lorenza Macri, Roberta Bava, Irene Carresi, Cristina Gliozzi, Micaela Musolino, Vincenzo Cardamone, Antonio Coppoletta, Anna Rita Barillaro, Andrea Simari, Virginia Salvemini, Daniela Palma, Ernesto Mollace, Vincenzo TI The Phytochemical Synergistic Properties of Combination of Bergamot Polyphenolic Fraction and Cynara cardunculus Extract in Non-Alcoholic Fatty Liver Disease SO AGRICULTURE-BASEL LA English DT Review DE bergamot; bergamot polyphenolic fraction (BPF); Cynara cardunculus extract; non-alcoholic fatty liver disease (NAFLD); lipid lowering effects; lipid lowering nutraceuticals ID ARTICHOKE LEAF EXTRACT; LIPID-LOWERING NUTRACEUTICALS; STATIN-INTOLERANT PATIENTS; MEDITERRANEAN DIET; CITRUS-BERGAMIA; LIFE-STYLE; NAFLD PROGRESSION; LDL-CHOLESTEROL; PATHOGENESIS; PREVENTION AB Non-alcoholic fatty liver disease (NAFLD) is considered one of the leading causes of liver-related morbidity and mortality. NAFLD is a cluster of liver disorders that includes the accumulation of fat in the liver, insulin resistance, diffuse steatosis, lobular inflammation, fibrosis, cirrhosis and, in the latter stages, liver cancer. Due to the complexity of the disease and the multifactorial basis for the development of liver dysfunction, there is currently no unique drug treatment for NAFLD and the pharmacological options are inconclusive. In recent years, natural products have been studied for their potential beneficial effect in both preventing and treating fatty liver and its consequences in both local and systemic effects related to NAFLD. In particular, bergamot polyphenolic fraction (BPF), which is rich in natural polyphenols, and Cynara cardunculus wild type (which contains large quantities of sesquiterpenes, caffeic acid derivatives and luteolin) have both been investigated in both pre-clinical settings and clinical studies showing their effect in counteracting NAFLD-related health issues. In the present review we summarize the experimental and clinical evidence on the effect of BPF and Cynara extract alone or in their combination product (Bergacyn((R))) in NAFLD. In particular, data reported show that both extracts may synergize in counteracting the pathophysiological basis of NAFLD by inhibiting lipid accumulation in liver cells, oxidative stress and inflammation subsequent to liver syeatosis and, in the latter stages, liver fibrosis and tissue degeneration. Moreover, due to its powerful vasoprotective effect, the combination of BPF and Cynara extract (Bergacyn((R))) leads to improved endothelial dysfunction and cardioprotective response in both animal models of NAFLD, in veterinary medicine and in humans. Thus, supplementation with BPF and Cynara cardunculus extract and their combination product (Bergacyn((R))) represent a novel and potentially useful approach in preventing and treating NAFLD-associated complications. C1 [Maiuolo, Jessica; Musolino, Vincenzo] Magna Graecia Univ Catanzaro, IRC FSH Ctr, Dept Hlth Sci, Lab Pharmaceut Biol, I-88100 Catanzaro, Italy. [Mollace, Rocco] San Raffaele Telematic Univ, I-00163 Rome, Italy. [Bosco, Francesca; Scarano, Federica; Oppedisano, Francesca; Nucera, Saverio; Ruga, Stefano; Guarnieri, Lorenza; Macri, Roberta; Bava, Irene; Carresi, Cristina; Gliozzi, Micaela; Cardamone, Antonio; Coppoletta, Anna Rita; Barillaro, Andrea; Simari, Virginia; Palma, Ernesto; Mollace, Vincenzo] Magna Graecia Univ Catanzaro, IRC FSH Ctr Dept Hlth Sci, I-88100 Catanzaro, Italy. [Salvemini, Daniela] Univ St Luois, St Louis, MO 63103 USA. [Mollace, Vincenzo] Nutramed Scarl, I-88021 Catanzaro, Italy. C3 Magna Graecia University of Catanzaro; Magna Graecia University of Catanzaro RP Maiuolo, J (通讯作者)，Magna Graecia Univ Catanzaro, IRC FSH Ctr, Dept Hlth Sci, Lab Pharmaceut Biol, I-88100 Catanzaro, Italy.; Mollace, V (通讯作者)，Magna Graecia Univ Catanzaro, IRC FSH Ctr Dept Hlth Sci, I-88100 Catanzaro, Italy.; Mollace, V (通讯作者)，Nutramed Scarl, I-88021 Catanzaro, Italy. EM maiuolo@unicz.it; mollace@libero.it RI Coppoletta, Anna Rita/LSK-7367-2024; Ruga, Stefano/JUV-6384-2023; PALMA, Ernesto/KRP-9299-2024; Bosco, Francesca/HPF-0108-2023; carresi, cristina/AAC-6354-2022; Oppedisano, Francesca/GRJ-8297-2022; Musolino, Vincenzo/AAC-6429-2022; Gliozzi, Micaela/D-4405-2015; nucera, saverio/AAC-6570-2022; MACRI', Roberta/IQR-9234-2023; Maiuolo, Jessica/AAU-2482-2020; SCARANO, FEDERICA/HNC-2414-2023; Mollace, Rocco/ABH-5643-2020; Cardamone, Antonio/HGA-5612-2022 OI Coppoletta, Anna Rita/0009-0000-5576-1139; Ruga, Stefano/0009-0008-0401-4027; mollace, vincenzo/0000-0002-0392-7173; PALMA, Ernesto/0000-0003-4199-207X; Bosco, Francesca/0009-0004-4766-9710; carresi, cristina/0000-0002-3509-5930; Oppedisano, Francesca/0000-0003-0930-8987; Guarnieri, Lorenza/0009-0007-5865-8779; MACRI', Roberta/0000-0002-2345-6751; SCARANO, FEDERICA/0000-0002-9838-9469; Mollace, Rocco/0000-0002-7106-5595; Cardamone, Antonio/0000-0002-9091-1806 FU [PONa3 00359] FX The work was supported by public resources from the Italian Ministry of Research. 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OA Green Submitted, gold DA 2026-02-02 ER PT J AU Schepp, M Freuer, D Wawro, N Peters, A Heier, M Teupser, D Meisinger, C Linseisen, J AF Schepp, M. Freuer, D. Wawro, N. Peters, A. Heier, M. Teupser, D. Meisinger, C. Linseisen, J. TI Association of the habitual dietary intake with the fatty liver index and effect modification by metabotypes in the population-based KORA-Fit study SO LIPIDS IN HEALTH AND DISEASE LA English DT Article DE Diet; Fatty liver index; Food groups; Carbohydrates; Metabotype ID MEDITERRANEAN DIET; RISK-FACTORS; DISEASE; INFLAMMATION; CONSUMPTION; NUTRITION; QUALITY; OBESITY; ADULTS; LIFE AB Background Non-alcoholic fatty liver disease (NAFLD) is an emerging threat for public health with diet being a major risk factor in disease development and progression. However, the effects of habitual food consumption on fatty liver are still inconclusive as well as the proposed role of the individuals' metabolic profiles. Therefore, the aim of our study is to examine the associations between diet and NAFLD with an emphasis on the influence of specific metabotypes in the general population.Methods A total of 689 participants (304 men and 385 women) of the KORA-Fit (S4) survey, a follow-up study of the population-based KORA cohort study running in the Region of Augsburg, Germany, were included in this analysis. Dietary information was derived from repeated 24-h food lists and a food frequency questionnaire. The intake of energy and energy-providing nutrients were calculated using the national food composition database. The presence of fatty liver was quantified by the fatty liver index (FLI), and metabotypes were calculated using K-means clustering. Multivariable linear regression models were used for the analysis of habitual food groups and FLI; for the evaluation of macronutrients, energy substitution models were applied.Results A higher consumption of nuts and whole grains, and a better diet quality (according to Alternate Healthy Eating Index and Mediterranean Diet Score) were associated with lower FLI values, while the intake of soft drinks, meat, fish and eggs were associated with a higher FLI. The isocaloric substitution of carbohydrates with polyunsaturated fatty acids was associated with a decreased FLI, while substitution with monounsaturated fatty acids and protein showed increased FLI. Statistically significant interactions with the metabotype were observed for most food groups.Conclusion The consumption of plant-based food groups, including nuts and whole grains, and diet quality, were associated with lower FLI values, whereas the intake of soft drinks and products of animal origin (meat, fish, eggs) were associated with a higher FLI. The observed statistically significant interactions with the metabotype for most food groups could help to develop targeted prevention strategies on a population-based level if confirmed in independent prospective studies. C1 [Schepp, M.; Freuer, D.; Wawro, N.; Meisinger, C.; Linseisen, J.] Univ Augsburg, Univ Hosp Augsburg, Epidemiol Augsburg, Augsburg, Germany. [Wawro, N.; Peters, A.; Heier, M.] Helmholtz Zentrum Munchen, Inst Epidemiol, German Res Ctr Environm Hlth GmbH, Neuherberg, Germany. [Peters, A.] Ludwig Maximilians Univ Munchen, Inst Med Informat Proc Biometry & Epidemiol, Med Fac, Chair Epidemiol, Munich, Germany. [Peters, A.] German Ctr Diabet Res DZD, Munich Neuherberg, Germany. [Heier, M.] Univ Hosp Augsburg, KORA Study Ctr, Augsburg, Germany. [Teupser, D.] Ludwig Maximilians Univ Munchen, Univ Hosp, Inst Lab Med, Munich, Germany. [Linseisen, J.] Ludwig Maximilians Univ Munchen, Med Fac, Inst Med Informat Proc Biometry & Epidemiol, Munich, Germany. C3 University of Augsburg; Helmholtz Association; Helmholtz-Center Munich - German Research Center for Environmental Health; University of Munich; German Center for Diabetes Research (DZD); University of Munich; University of Munich RP Schepp, M (通讯作者)，Univ Augsburg, Univ Hosp Augsburg, Epidemiol Augsburg, Augsburg, Germany. EM m.schepp@stud.uni-heidelberg.de RI Linseisen, Jakob/B-5353-2014; Peters, Annette/A-6117-2011; Meisinger, Christa/KYQ-6817-2024; Heier, Margit/AAT-5280-2020 OI Peters, Annette/0000-0001-6645-0985; FU Universittsklinikum Augsburg (8972) FX The authors thank all participants of the KORA FIT study for their contribution. 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PD APR 4 PY 2024 VL 23 IS 1 AR 99 DI 10.1186/s12944-024-02094-0 PG 13 WC Biochemistry & Molecular Biology; Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Biochemistry & Molecular Biology; Nutrition & Dietetics GA MY3Z6 UT WOS:001197170400001 PM 38575962 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Geh, D Anstee, QM Reeves, HL AF Geh, Daniel Anstee, Quentin M. Reeves, Helen L. TI NAFLD-Associated HCC: Progress and Opportunities SO JOURNAL OF HEPATOCELLULAR CARCINOMA LA English DT Review DE hepatocellular carcinoma; HCC; nonalcoholic fatty liver disease; NAFLD; liver cirrhosis; biomarkers; prevention; systemic therapy; immunotherapy ID FATTY LIVER-DISEASE; RS641738 INCREASES RISK; HEPATOCELLULAR-CARCINOMA; NONALCOHOLIC STEATOHEPATITIS; WIDE ASSOCIATION; FIBROSIS PROGRESSION; MEDITERRANEAN DIET; 1ST-LINE TREATMENT; GENDER DISPARITY; UNITED-STATES AB Due to an increase in the obesity-associated metabolic syndrome of epidemic proportions, nonalcoholic fatty liver disease (NAFLD) is becoming a leading cause of hepatocellular carcinoma (HCC) in western countries. This presents added challenges, as NAFLD-associated HCC tends to present at an advanced stage in older patients with comorbidities. Their prognosis is generally poor with the benefits of standard therapies less certain. The pathogenesis of NAFLD-associated HCC is multifactorial and not well understood, although the risk of HCC developing undoubtedly increases as NAFLD progresses to steatohepatitis and cirrhosis. Recent advances in our understanding of the drivers of NAFLD and HCC will hopefully lead to the development of clinically relevant biomarkers, tools and strategies to aid the identification of high-risk patients, inform preventive measures, and introduction of better tolerated targeted therapies. Lifestyle modification and chemoprevention with drugs such as anti-platelets, statins and anti-diabetics are being evaluated for HCC prevention. The landmark IMBrave150 study introducing the combination of atezolizumab and bevacizumab has recently transformed the landscape of systemic therapies in HCC, with follow-up analyses and real-world data for patients with NAFLD-associated HCC eagerly anticipated. While responses may vary in ways not yet appreciated, the rate of discovery and progress suggests imminent change and opportunities. C1 [Geh, Daniel] Newcastle Univ, Fac Med Sci, Biosci Inst, Newcastle Upon Tyne, Tyne & Wear, England. [Anstee, Quentin M.; Reeves, Helen L.] Newcastle Univ, Fac Med Sci, Translat & Clin Res Inst, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England. [Anstee, Quentin M.; Reeves, Helen L.] Newcastle Tyne Hosp NHS Fdn Trust, Freeman Hosp, Liver Unit, Newcastle Upon Tyne, Tyne & Wear, England. [Reeves, Helen L.] Newcastle Tyne Hosp NHS Fdn Trust, Freeman Hosp, Hepatopancreatobiliary Multidisciplinary Team, Newcastle Upon Tyne, Tyne & Wear, England. C3 Newcastle University - UK; Newcastle University - UK; Newcastle Upon Tyne Hospitals NHS Foundation Trust; Newcastle Freeman Hospital; Newcastle Upon Tyne Hospitals NHS Foundation Trust; Newcastle Freeman Hospital RP Reeves, HL (通讯作者)，Newcastle Univ, Fac Med Sci, Translat & Clin Res Inst, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England. EM h.l.reeves@ncl.ac.uk RI Geh, Daniel/AAI-1573-2021; Anstee, Quentin M/L-2981-2013 OI Geh, Daniel/0000-0002-3592-7469; Anstee, Quentin M/0000-0002-9518-0088; Reeves, Helen/0000-0003-0359-9795 FU Newcastle CRUK Clinical Academic Training Programme FX Dr Daniel Geh is funded by the Newcastle CRUK Clinical Academic Training Programme. Professor Quentin M Anstee reports research grant funding from Abbvie, Allergan/Tobira, AstraZeneca, GlaxoSmithKline, Glympse Bio, Novartis Pharma AG, Pfizer Ltd., Vertex. He is also involved in active research collaborations (including research collaborations sup-ported through the EU IMI2 LITMUS Consortium*) with Abbvie, Antaros Medical*, Allergan/Tobira*, AstraZeneca*, BMS*, Boehringer Ingelheim International GMBH*, Echosens*, Ellegaard Gottingen Minipigs AS*, Eli Lilly & Company Ltd.*, Exalenz Bioscience Ltd.*, Genfit SA*, Glympse Bio, GlaxoSmithKline, HistoIndex*, Intercept Pharma Europe Ltd.*, iXscient Ltd.*, Nordic Bioscience*, Novartis Pharma AG*, Novo Nordisk A/S*, One Way Liver Genomics SL*, Perspectum Diagnostics*, Pfizer Ltd.*, Resoundant*, Sanofi-Aventis Deutschland GMBH*, SomaLogic Inc.*, Takeda Pharmaceuticals International SA*; consultancy for 89Bio, Abbott Laboratories, Acuitas Medical, Allergan/Tobira, Altimmune, AstraZeneca, Axcella, Blade, BMS, BNN Cardio, Celgene, Cirius, CymaBay, EcoR1, E3Bio, Eli Lilly & Company Ltd., Galmed, Genentech, Genfit SA, Gilead, Grunthal, HistoIndex, Indalo, Imperial Innovations, Intercept Pharma Europe Ltd., Inventiva, IQVIA, Janssen, Madrigal, MedImmune, Metacrine, NewGene, NGMBio, North Sea Therapeutics, Novartis, Novo Nordisk A/S, PathAI, Pfizer Ltd., Poxel, ProSciento, Raptor Pharma, Servier, Terns, Viking Therapeutics. Speaker Abbott Laboratories, Allergan/Tobira, BMS, Clinical Care Options, Falk, Fishawack, Genfit SA, Gilead, Integritas Communications, Kenes, Medscape; royalties from Elsevier Ltd (Davidson's Principles & Practice of Medicine textbook). Professor Quentin M Anstee and Professor Helen L Reeves receive support from the CRUK HUNTER Accelerator Award (C9380/A26813). Professor Helen L Reeves also reports speaker honoraria from Bayer and Eisai. The authors report no other conflicts of interest in this work. 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CARCINOMA PY 2021 VL 8 BP 223 EP 239 DI 10.2147/JHC.S272213 PG 17 WC Oncology WE Science Citation Index Expanded (SCI-EXPANDED) SC Oncology GA RO8FW UT WOS:000641277500001 PM 33854987 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Yang, ZF Tian, RF Zhang, XJ Cai, JJ She, ZG Li, HL AF Yang, Zifeng Tian, Ruifeng Zhang, Xiao-Jing Cai, Jingjing She, Zhi-Gang Li, Hongliang TI Effects of treatment of non-alcoholic fatty liver disease on heart failure with preserved ejection fraction SO FRONTIERS IN CARDIOVASCULAR MEDICINE LA English DT Review DE nonalcoholic fatty liver disease; heart failure with preserved ejection fraction; risk factor; systemic inflammation; secretory factors; epicardial adipose tissue; treatment ID EPICARDIAL ADIPOSE-TISSUE; MEDITERRANEAN DIET; HEPATIC STEATOSIS; WEIGHT-LOSS; BARIATRIC SURGERY; OXIDATIVE STRESS; STATIN THERAPY; MYOCARDIAL DYSFUNCTION; AMERICAN ASSOCIATION; TRANSCRIPTION FACTOR AB In the past few decades, non-alcoholic fatty liver disease (NAFLD) and heart failure with preserved ejection fraction (HFpEF) have become the most common chronic liver disease and the main form of heart failure (HF), respectively. NAFLD is closely associated with HFpEF by sharing common risk factors and/or by boosting systemic inflammation, releasing other secretory factors, and having an expansion of epicardial adipose tissue (EAT). Therefore, the treatments of NAFLD may also affect the development and prognosis of HFpEF. However, no specific drugs for NAFLD have been approved by the Food and Drug Administration (FDA) and some non-specific treatments for NAFLD are applied in the clinic. Currently, the treatments of NAFLD can be divided into non-pharmacological and pharmacological treatments. Non-pharmacological treatments mainly include dietary intervention, weight loss by exercise, caloric restriction, and bariatric surgery. Pharmacological treatments mainly include administering statins, thiazolidinediones, glucagon-like peptide-1 receptor agonists, sodium-glucose cotransporter 2 inhibitors, and metformin. This review will mainly focus on analyzing how these treatments may affect the development and prognosis of HFpEF. C1 [Yang, Zifeng; Tian, Ruifeng; She, Zhi-Gang; Li, Hongliang] Renmin Hosp Wuhan Univ, Dept Cardiol, Wuhan, Peoples R China. [Yang, Zifeng; Tian, Ruifeng; Zhang, Xiao-Jing; She, Zhi-Gang; Li, Hongliang] Wuhan Univ, Inst Model Anim, Wuhan, Peoples R China. [Zhang, Xiao-Jing; Li, Hongliang] Wuhan Univ, Sch Basic Med Sci, Wuhan, Peoples R China. [Cai, Jingjing] Cent South Univ, Xiangya Hosp 3, Dept Cardiol, Changsha, Peoples R China. [Li, Hongliang] Gannan Med Univ, Gannan Innovat & Translat Med Res Inst, Ganzhou, Peoples R China. C3 Wuhan University; Wuhan University; Wuhan University; Central South University; Gannan Medical University RP She, ZG; Li, HL (通讯作者)，Renmin Hosp Wuhan Univ, Dept Cardiol, Wuhan, Peoples R China.; She, ZG; Li, HL (通讯作者)，Wuhan Univ, Inst Model Anim, Wuhan, Peoples R China.; Li, HL (通讯作者)，Wuhan Univ, Sch Basic Med Sci, Wuhan, Peoples R China.; Li, HL (通讯作者)，Gannan Med Univ, Gannan Innovat & Translat Med Res Inst, Ganzhou, Peoples R China. EM zgshe@whu.edu.cn; lihl@whu.edu.cn RI She, Zhi-Gang/AFP-9194-2022; Cai, Jingjing/JXN-8391-2024; She, Zhi-Gang/AFP-9194-2022 OI Yang, Zifeng/0009-0006-9149-4166; She, Zhi-Gang/0000-0001-9402-4166 FU National Natural Science Foundation of China [82270390, 81970364, 82170595, 82170436, 81970070]; Hubei Province Innovation Platform Construction Project [20204201117303072238] FX Funding This work was supported by grants from the National Natural Science Foundation of China (82270390, 81970364, 82170595, 82170436, and 81970070) and the Hubei Province Innovation Platform Construction Project (20204201117303072238). 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NR 176 TC 8 Z9 8 U1 4 U2 27 PU FRONTIERS MEDIA SA PI LAUSANNE PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND SN 2297-055X J9 FRONT CARDIOVASC MED JI Front. Cardiovasc. Med. PD JAN 12 PY 2023 VL 9 AR 1120085 DI 10.3389/fcvm.2022.1120085 PG 12 WC Cardiac & Cardiovascular Systems WE Science Citation Index Expanded (SCI-EXPANDED) SC Cardiovascular System & Cardiology GA 8C7RF UT WOS:000917800600001 PM 36712249 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Sangouni, AA Zadeh, SH Mozaffari-Khosravi, H Hosseinzadeh, M AF Sangouni, Abbas Ali Zadeh, Shirin Hassani Mozaffari-Khosravi, Hassan Hosseinzadeh, Mahdieh TI Effect of Mediterranean diet on liver enzymes: a systematic review and meta-analysis of randomised controlled trials SO BRITISH JOURNAL OF NUTRITION LA English DT Review DE Mediterranean diet; Liver enzyme; Meta-analysis; Systematic review ID TYPE-2 DIABETES PATIENTS; METABOLIC SYNDROME; HEPATIC STEATOSIS; LIFE-STYLE; DISEASE; FIBER; OBESITY; MANAGEMENT; GLUCOSE; REDUCTION AB Elevated levels of liver enzymes are the main markers of liver dysfunction. Liver enzymes are the important indicators of non-alcoholic fatty liver disease (NAFLD) in the general population. Previous randomised clinical trials (RCT) investigated the effects of Mediterranean diet (MedDiet) as a plant-based diet on features of NAFLD like liver enzymes, but their results are contradictory. This study aimed to systematically review and meta-analyse RCT investigating the effect of MedDiet on liver enzymes. PubMed, Web of Science, Scopus and Google Scholar were searched until December 2020. A total of ten RCT (n 705 participants) evaluating the effect of MedDiet on liver enzymes including aspartate aminotransferase (AST), alanine transaminase (ALT) and gamma-glutamyltransferase (GGT) were included. A random effects model was used to estimate the pooled effect size. To evaluate the heterogeneity among the included studies, the Cochran's Q-test and I-squared test were used. The MedDiet significantly reduced AST (weighted mean difference (WMD) = -0 center dot 38 IU/l; 95 % CI - 0 center dot 73, -0 center dot 03 IU/l; P = 0 center dot 03) and GGT (WMD = -0 center dot 16 IU/l; 95 % CI - 0 center dot 32, -0 center dot 006 IU/l; P = 0 center dot 04) but had no significant effect on ALT (WMD = -0 center dot 55 IU/l; 95 % CI - 1 center dot 25, 0 center dot 13 IU/l; P = 0 center dot 11). However, sensitivity analysis revealed that the overall effects of MedDiet on AST, GGT and ALT were significantly influenced by removing some studies. There was no publication bias based on Begg's and Egger's tests. Generally, MedDiet can improve liver enzymes. To better conclusion, further RCT investigating the effect of MedDiet on liver enzymes, especially in patients with NAFLD, are still required. C1 [Sangouni, Abbas Ali; Zadeh, Shirin Hassani; Mozaffari-Khosravi, Hassan; Hosseinzadeh, Mahdieh] Shahid Sadoughi Univ Med Sci, Nutr & Food Secur Res Ctr, Yazd, Iran. [Sangouni, Abbas Ali; Zadeh, Shirin Hassani; Mozaffari-Khosravi, Hassan; Hosseinzadeh, Mahdieh] Shahid Sadoughi Univ Med Sci, Sch Publ Hlth, Dept Nutr, Yazd, Iran. C3 Shahid Sadoughi University of Medical Sciences; Shahid Sadoughi University of Medical Sciences RP Hosseinzadeh, M (通讯作者)，Shahid Sadoughi Univ Med Sci, Nutr & Food Secur Res Ctr, Yazd, Iran.; Hosseinzadeh, M (通讯作者)，Shahid Sadoughi Univ Med Sci, Sch Publ Hlth, Dept Nutr, Yazd, Iran. 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PD OCT 14 PY 2022 VL 128 IS 7 SI SI BP 1231 EP 1239 AR PII S0007114521002270 DI 10.1017/S0007114521002270 EA JUN 2021 PG 9 WC Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Nutrition & Dietetics GA 5A5AG UT WOS:000744711400001 PM 34165054 DA 2026-02-02 ER PT J AU Gori, M Giannitelli, SM Zancla, A Mozetic, P Trombetta, M Merendino, N Rainer, A AF Gori, Manuele Giannitelli, Sara Maria Zancla, Andrea Mozetic, Pamela Trombetta, Marcella Merendino, Nicolo Rainer, Alberto TI Quercetin and hydroxytyrosol as modulators of hepatic steatosis: A NAFLD-on-a-chip study SO BIOTECHNOLOGY AND BIOENGINEERING LA English DT Article DE hepatic steatosis; high-content analysis; liver-on-a-chip; microfluidics; polyphenols ID FATTY LIVER-DISEASE; OLIVE OIL; ANTIOXIDANT ACTIVITY; LIPID-ACCUMULATION; MEDITERRANEAN DIET; INSULIN-RESISTANCE; METABOLIC SYNDROME; IN-VITRO; ACID; INFLAMMATION AB Organs-on-chip (OoCs) are catching on as a promising and valuable alternative to animal models, in line with the 3Rs initiative. OoCs enable the creation of three-dimensional (3D) tissue microenvironments with physiological and pathological relevance at unparalleled precision and complexity, offering new opportunities to model human diseases and to test the potential therapeutic effect of drugs, while overcoming the limited predictive accuracy of conventional 2D culture systems. Here, we present a liver-on-a-chip model to investigate the effects of two naturally occurring polyphenols, namely quercetin and hydroxytyrosol, on nonalcoholic fatty liver disease (NAFLD) using a high-content analysis readout methodology. NAFLD is currently the most common form of chronic liver disease; however, its complex pathogenesis is still far from being elucidated, and no definitive treatment has been established so far. In our experiments, we observed that both polyphenols seem to restrain the progression of the free fatty acid-induced hepatocellular steatosis, showing a cytoprotective effect due to their antioxidant and lipid-lowering properties. In conclusion, the findings of the present work could guide novel strategies to contrast the onset and progression of NAFLD. C1 [Gori, Manuele; Giannitelli, Sara Maria; Zancla, Andrea; Trombetta, Marcella; Rainer, Alberto] Univ Campus Biomed Roma, Dept Engn, Rome, Italy. [Zancla, Andrea] Univ Roma Tre, Dept Engn, Rome, Italy. [Mozetic, Pamela] St Annes Univ Hosp, Int Clin Res Ctr, Ctr Translat Med, Brno, Czech Republic. [Mozetic, Pamela; Rainer, Alberto] CNR, Inst Nanotechnol NANOTEC, Lecce, Italy. [Merendino, Nicolo] Univ Tuscia, Dept Ecol & Biol Sci, Viterbo, Italy. [Rainer, Alberto] Interuniv Ctr Promot 3Rs Principles Teaching & Re, Pisa, Italy. C3 University Campus Bio-Medico - Rome Italy; Roma Tre University; St. Anne's University Hospital Brno (FNUSA); St. Anne's University Hospital Brno (FNUSA-ICRC); Consiglio Nazionale delle Ricerche (CNR); Istituto di Nanotecnologia (NANOTEC-CNR); Tuscia University RP Rainer, A (通讯作者)，Univ Campus Biomed Roma, Via Alvaro Portillo 21, I-00128 Rome, Italy. EM a.rainer@unicampus.it RI Rainer, Alberto/G-8588-2011; Merendino, Nicolò/N-7661-2013; Zancla, Anea/AAI-9319-2020; Gori, Manuele/J-9184-2016; Giannitelli, Sara Maria/AAC-1819-2019; Mozetic, Pamela/AAE-3850-2021 OI Rainer, Alberto/0000-0001-8971-551X; Merendino, Nicolò/0000-0001-5044-1398; Zancla, Anea/0000-0001-7900-6787; Gori, Manuele/0000-0001-6957-2718; Giannitelli, Sara Maria/0000-0002-3616-5953; Mozetic, Pamela/0000-0001-8641-0526; Trombetta, Marcella/0000-0002-1357-4885 FU European Regional Development Fund [CZ.02.1.01/0.0/0.0/15_003/0000492]; Universita Campus Bio-Medico di Roma [009/2017]; FIRE (Fondazione Italiana per la Ricerca in Epatologia) Onlus; Regione Puglia [CUP B84I18000540002]; FISR/MIUR-CNR [CUP B83B17000010001] FX European Regional Development Fund, Grant/Award Number: CZ.02.1.01/0.0/0.0/15_003/0000492; Universita Campus Bio-Medico di Roma, Grant/Award Number: Technology Transfer Grant (#009/2017 "ITHACa"); FIRE (Fondazione Italiana per la Ricerca in Epatologia) Onlus, Grant/Award Number: FIRE Research Fellowship 2017; 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Bioeng. PD JAN PY 2021 VL 118 IS 1 BP 142 EP 152 DI 10.1002/bit.27557 EA SEP 2020 PG 11 WC Biotechnology & Applied Microbiology WE Science Citation Index Expanded (SCI-EXPANDED) SC Biotechnology & Applied Microbiology GA PM5OY UT WOS:000570318900001 PM 32889748 DA 2026-02-02 ER PT J AU Koch, M Nöthlings, U Lieb, W AF Koch, Manja Noethlings, Ute Lieb, Wolfgang TI Dietary patterns and fatty liver disease SO CURRENT OPINION IN LIPIDOLOGY LA English DT Review DE dietary patterns; hepatic steatosis; review ID MEDITERRANEAN DIET; HEPATIC STEATOSIS; NUTRITIONAL EPIDEMIOLOGY; CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; PHYSICAL-ACTIVITY; UNITED-STATES; POPULATION; PREVALENCE; NAFLD AB Purpose of review The association of dietary intake and fatty liver disease (FLD) is of importance for disease prevention. Dietary pattern analysis enables the investigation of overall diet and permits to take interactions and cumulative effects of dietary components into account. This review summarizes recent findings on the association of dietary patterns and FLD. Recent findings A systematic review of articles published from March 2013 to August 2014 identified four relevant observational (n = 116-995) and one interventional study (n = 12). The Healthy Eating Index and Dietary Diversity Scores were not related to nonalcoholic FLD. A Mediterranean diet intervention resulted in a significant decrease in liver fat content over 6 weeks. Exploratory approaches revealed a 'Western pattern' and a pattern having alcohol, meat (poultry) and tea in common with a hypothesis-driven pattern, which were both associated with FLD. Summary Most studies were limited by a cross-sectional design and small-to-moderate sample sizes. Observational studies applying exploratory approaches and a Mediterranean diet intervention demonstrated most promising results relating dietary patterns to FLD. Prospective studies with measurement of liver fat on a continuous scale at multiple time points in large samples are important requisites to improve our understanding of FLD cause. C1 [Koch, Manja; Lieb, Wolfgang] Univ Kiel, Inst Epidemiol, D-24105 Kiel, Germany. [Noethlings, Ute] Univ Bonn, Dept Nutr & Food Sci, Bonn, Germany. C3 University of Kiel; University of Bonn RP Koch, M (通讯作者)，Univ Kiel, Inst Epidemiol, Campus UK SH,Arnold Heller Str 3, D-24105 Kiel, Germany. EM manja.koch@epi.uni-kiel.de RI ; Lieb, Wolfgang/AAC-7650-2022; Nöthlings, Ute/B-2713-2010 OI Koch, Manja/0000-0002-4794-4821; Nöthlings, Ute/0000-0002-5789-2252 FU Deutsche Forschungsgemeinschaft Excellence Cluster 'Inflammation at Interfaces' [EXC306, EXC306/2]; German Federal Ministry of Education and Research [01GR0468, 01EY1103] FX This work was supported by grants from the Deutsche Forschungsgemeinschaft Excellence Cluster 'Inflammation at Interfaces' (EXC306, EXC306/2) and through grants from the German Federal Ministry of Education and Research (01GR0468). The PopGen 2.0 network is supported by a grant from the German Federal Ministry of Education and Research (01EY1103). The funders had no role in the study design, collection, and interpretation of the data and in the writing of the manuscript. 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Opin. Lipidology PD FEB PY 2015 VL 26 IS 1 BP 35 EP 41 DI 10.1097/MOL.0000000000000141 PG 7 WC Biochemistry & Molecular Biology; Endocrinology & Metabolism; Peripheral Vascular Disease WE Science Citation Index Expanded (SCI-EXPANDED) SC Biochemistry & Molecular Biology; Endocrinology & Metabolism; Cardiovascular System & Cardiology GA AY0OS UT WOS:000347296600006 PM 25501880 DA 2026-02-02 ER PT J AU Adriano, LS Sampaio, HAD Arruda, SPM Portela, CLD de Melo, MLP Carioca, AAF Soares, NT AF Adriano, Lia Silveira de Carvalho Sampaio, Helena Alves Machado Arruda, Soraia Pinheiro de Melo Portela, Clarissa Lima Pereira de Melo, Maria Luisa Ferreira Carioca, Antonio Augusto Soares, Nadia Tavares TI Healthy dietary pattern is inversely associated with non-alcoholic fatty liver disease in elderly SO BRITISH JOURNAL OF NUTRITION LA English DT Article DE Non-alcoholic fatty liver disease; Dietary patterns; Elderly population ID MEDITERRANEAN DIET; MANAGEMENT; SURVIVAL; INDEX AB The prevalence of non-alcoholic fatty liver disease (NAFLD) is rising, an increase that may be associated with changes in lifestyle such as unhealthy dietary patterns. Although advanced age is a risk factor for NAFLD, no studies reporting this association in the elderly population were found. In the present study, the association between dietary patterns and NAFLD in the elderly was assessed. A study including 229 older adults was conducted. NAFLD diagnosis was defined as individuals whose ultrasound examination disclosed hepatic steatosis at any stage, in the absence of excess intake of alcoholic beverages. Dietary patterns were obtained by principal components analysis. Mean scores and standard errors of each dietary pattern were calculated for the groups with and without NAFLD, and mean scores of the two groups were compared using the Mann-Whitney U test. The prevalence ratios and 95% CI were estimated for each tertile of the dietary pattern adherence scores using Poisson multiple regression models with robust variance. A total of 103 (45 %) elderly with NAFLD and four dietary patterns were identified: traditional, regional snacks, energy dense and healthy. Mean scores for adherence to the healthy pattern in the groups with and without NAFLD differed. NAFLD was inversely associated with greater adherence to the healthy pattern and directly associated with the regional snacks, after adjustment for confounders. In conclusion, healthy dietary pattern is inversely associated with NAFLD in elderly. C1 [Adriano, Lia Silveira; de Carvalho Sampaio, Helena Alves; Machado Arruda, Soraia Pinheiro; Pereira de Melo, Maria Luisa; Soares, Nadia Tavares] Univ Estadual Ceara, Dept Nutr, Ave Dr Silas Munguba 1700, BR-60714903 Fortaleza, Ceara, Brazil. [Adriano, Lia Silveira; de Melo Portela, Clarissa Lima] Univ Fortaleza, Ave Washington Soares 1321, BR-60811905 Fortaleza, Ceara, Brazil. [Ferreira Carioca, Antonio Augusto] Univ Sao Paulo, Sch Publ Hlth, Dept Nutr, Ave Dr Arnaldo 715, BR-01246000 Sao Paulo, SP, Brazil. C3 Universidade Estadual do Ceara; Universidade Fortaleza; Universidade de Sao Paulo RP Soares, NT (通讯作者)，Univ Estadual Ceara, Dept Nutr, Ave Dr Silas Munguba 1700, BR-60714903 Fortaleza, Ceara, Brazil. EM nadiatsoares@gmail.com RI sampaio, helena/ABD-1981-2020; Carioca, Antonio Augusto/LIG-1663-2024 OI Carioca, Antonio Augusto/0000-0002-1194-562X CR de Matos SMA, 2014, CAD SAUDE PUBLICA, V30, P44, DOI 10.1590/0102-311X00164712 Anderson AL, 2011, J AM DIET ASSOC, V111, P84, DOI 10.1016/j.jada.2010.10.012 [Anonymous], 1995, Report of a WHO Expert Committee [Anonymous], SER SYST REV REL DIE [Anonymous], TERAPIA NUTR DOENCAS Bamia C, 2007, PUBLIC HEALTH NUTR, V10, P590, DOI 10.1017/S1368980007382487 Barros Aluisio J D, 2003, BMC Med Res Methodol, V3, P21, DOI 10.1186/1471-2288-3-21 Bertolotti M, 2014, WORLD J GASTROENTERO, V20, P14185, DOI 10.3748/wjg.v20.i39.14185 Brandao A.P., 2005, Arquivos Brasileiros de Cardiologia, V2, P1 Chalasani N, 2012, HEPATOLOGY, V55, P2005, DOI 10.1002/hep.25762 Selem SSD, 2014, J ACAD NUTR DIET, V114, P1216, DOI 10.1016/j.jand.2014.01.007 Fan JG, 2013, J GASTROEN HEPATOL, V28, P81, DOI 10.1111/jgh.12244 Garrett Bridgette E., 2011, Morbidity and Mortality Weekly Report, V60, P109 Gu Y, 2011, CURR ALZHEIMER RES, V8, P510, DOI 10.2174/156720511796391836 Hair JF, 2009, ANALISE MULTIVARIADA, V6, P100 Harttig U, 2011, EUR J CLIN NUTR, V65, pS87, DOI 10.1038/ejcn.2011.92 Haubrock J, 2011, J NUTR, V141, P914, DOI 10.3945/jn.109.120394 Jia Q, 2015, EUR J CLIN NUTR, V69, P914, DOI 10.1038/ejcn.2014.297 KAISER HF, 1974, PSYCHOMETRIKA, V39, P31, DOI 10.1007/BF02291575 Koch M, 2015, CURR OPIN LIPIDOL, V26, P35, DOI 10.1097/MOL.0000000000000141 Kontogianni MD, 2014, CLIN NUTR, V33, P678, DOI 10.1016/j.clnu.2013.08.014 LaRowe TL, 2007, J AM DIET ASSOC, V107, P1124, DOI 10.1016/j.jada.2007.04.013 LIPSCHITZ DA, 1994, PRIMARY CARE, V21, P55 Machado MV, 2014, WORLD J GASTROENTERO, V20, P12956, DOI 10.3748/wjg.v20.i36.12956 Masala G, 2007, BRIT J NUTR, V98, P406, DOI 10.1017/S0007114507704981 Masarone M, 2014, REV RECENT CLIN TRIA, V9, P126, DOI 10.2174/1574887109666141216111143 Newby PK, 2004, NUTR REV, V62, P177, DOI [10.1301/rn.2004.may.177-203, 10.1111/j.1753-4887.2004.tb00040.x] Oddy WH, 2013, AM J GASTROENTEROL, V108, P778, DOI 10.1038/ajg.2013.95 Olinto M., 2007, Padroes alimentares: analise de componentes principai, P213 Ryan MC, 2013, J HEPATOL, V59, P138, DOI 10.1016/j.jhep.2013.02.012 Santos RD, 2015, BRIT J NUTR, V114, P822, DOI 10.1017/S0007114515002445 Valtueña S, 2006, AM J CLIN NUTR, V84, P136, DOI 10.1093/ajcn/84.1.136 Yang CQ, 2015, NUTRIENTS, V7, P4778, DOI 10.3390/nu7064778 NR 33 TC 49 Z9 55 U1 0 U2 15 PU CAMBRIDGE UNIV PRESS PI CAMBRIDGE PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND SN 0007-1145 EI 1475-2662 J9 BRIT J NUTR JI Br. J. Nutr. PD JUN 28 PY 2016 VL 115 IS 12 BP 2189 EP 2195 DI 10.1017/S0007114516001410 PG 7 WC Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Nutrition & Dietetics GA DO7PB UT WOS:000377973400013 PM 27102566 OA Bronze DA 2026-02-02 ER PT J AU Mundi, MS Velapati, S Patel, J Kellogg, TA Abu Dayyeh, BK Hurt, RT AF Mundi, Manpreet S. Velapati, Saketh Patel, Janki Kellogg, Todd A. Abu Dayyeh, Barham K. Hurt, Ryan T. TI Evolution of NAFLD and Its Management SO NUTRITION IN CLINICAL PRACTICE LA English DT Review DE fatty liver; insulin resistance; liver cirrhosis; non-alcoholic fatty liver disease; nutrition therapy; weight loss ID FATTY LIVER-DISEASE; LIFE-STYLE MODIFICATION; TYPE-2 DIABETES-MELLITUS; NONALCOHOLIC STEATOHEPATITIS; VITAMIN-E; HEPATIC STEATOSIS; WEIGHT-LOSS; INSULIN-RESISTANCE; ALANINE AMINOTRANSFERASE; MEDITERRANEAN DIET AB The global prevalence of nonalcoholic fatty liver disease (NAFLD) is estimated to be 25% and continues to rise worldwide in the setting of the obesity epidemic. This increase is especially concerning because NAFLD is often a progressive disease that can be associated with significant complications such as liver cirrhosis, hepatocellular carcinoma, and an increase in liver-related and overall mortality. Because of the devastating complications and comorbidities, NAFLD is a very costly disease for the healthcare system, with estimated annual direct medical costs exceeding $100 billion in the United States alone. Given this progressive course, it is imperative to make the diagnosis in patients with risk factors (metabolic syndrome, weight gain, and insulin resistance/diabetes). Once the diagnosis is made, the focus should shift to treatment and monitoring for the development of associated complications. Given that currently no pharmaceutical intervention is approved for the treatment of NAFLD, focus shifts instead to mitigation of risk factors through avoidance of foods that are rich in red meat, trans fats, refined carbohydrates, and high-fructose corn syrup; are low fiber; and have high energy density. The landmark of treatment, however, continues to be weight loss and improvement of insulin resistance, often through a multimodality approach. 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Clin. Pract. PD FEB PY 2020 VL 35 IS 1 BP 72 EP 84 DI 10.1002/ncp.10449 EA DEC 2019 PG 13 WC Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Nutrition & Dietetics GA KC4AT UT WOS:000502641900001 PM 31840865 HC Y HP N DA 2026-02-02 ER PT J AU Bacil, GP Cogliati, B Cardoso, DR Barbisan, LF Romualdo, GR AF Bacil, Gabriel P. Cogliati, Bruno Cardoso, Daniel R. Barbisan, Luis Fernando Romualdo, Guilherme R. TI Are isothiocyanates and polyphenols from Brassicaceae vegetables emerging as preventive/therapeutic strategies for NAFLD? The landscape of recent preclinical findings SO FOOD & FUNCTION LA English DT Review ID FATTY LIVER-DISEASE; SUGAR-SWEETENED BEVERAGES; DIET-INDUCED OBESITY; HEPATIC STEATOSIS; ADIPOSE-TISSUE; INSULIN-RESISTANCE; CHLOROGENIC ACID; MEDITERRANEAN DIET; UNITED-STATES; INFLAMMATORY RESPONSE AB Nonalcoholic fatty liver disease (NAFLD) is a lipid impairment-related chronic metabolic disease that affects almost 25% of the worldwide population and has become the leading cause of liver transplantation in the United States of America (USA). NAFLD may progress from simple hepatic steatosis (HS) to nonalcoholic steatohepatitis (NASH), which occurs simultaneously in an inflammatory and fibrotic microenvironment and affects approximately 5% of the global population. Recently, NASH has been suggested to be a relevant driver in progressive liver cirrhosis and a population-attributable factor in hepatocellular carcinoma patients. Moreover, predictions show that NAFLD-related annual health costs in the USA have reached similar to$100 bi., but effective therapies are still scarce. Thus, new preventative strategies for this hepatic disease urgently need to be developed. The Brassicaceae vegetable family includes almost 350 genera and 3500 species and these are one of the main types of vegetables harvested and produced worldwide. These vegetables are well-known sources of glucobrassicin-derivative molecules, such as isothiocyanates and phenolic compounds, which have shown antioxidant and antilipogenic effects in preclinical NAFLD data. In this review, we gathered prominent evidence of the in vivo and in vitro effects of these vegetable-derived nutraceutical compounds on the gut-liver-adipose axis, which is a well-known regulator of NAFLD and may represent a new strategy for disease control. C1 [Bacil, Gabriel P.; Romualdo, Guilherme R.] Sao Paulo State Univ, UNESP, Botucatu Med Sch, Dept Pathol, Botucatu, SP, Brazil. [Cogliati, Bruno] Univ Sao Paulo, Sch Vet & Anim Sci, Dept Pathol, Sao Paulo, SP, Brazil. [Cardoso, Daniel R.] Univ Sao Paulo, Sao Carlos Inst Chem IQSC, Sao Carlos, SP, Brazil. [Barbisan, Luis Fernando; Romualdo, Guilherme R.] Sao Paulo State Univ, UNESP, Dept Struct & Funct Biol, Botucatu, SP, Brazil. C3 Universidade Estadual Paulista; Universidade de Sao Paulo; Universidade de Sao Paulo; Universidade Estadual Paulista RP Romualdo, GR (通讯作者)，Sao Paulo State Univ, UNESP, Botucatu Med Sch, Dept Pathol, Botucatu, SP, Brazil.; Romualdo, GR (通讯作者)，Sao Paulo State Univ, UNESP, Dept Struct & Funct Biol, Botucatu, SP, Brazil. EM guilherme.romualdo@unesp.br RI Cogliati, Bruno/E-9956-2012; Barbisan, Luis/AAX-8402-2021; Cardoso, Daniel R/IZE-2078-2023; Prata Bacil, Gabriel/AFT-5724-2022; Ribeiro Romualdo, Guilherme/AAB-4306-2020 OI Cardoso, Daniel R/0000-0002-3492-3327; Prata Bacil, Gabriel/0000-0003-3840-7749; Ribeiro Romualdo, Guilherme/0000-0001-5320-8380 FU Sao Paulo Research Foundation (FAPESP, Brazil) [2020/01078-7]; FAPESP [2020/01944-6, 2020/00377-0]; Coordination of Superior Level Staff Improvement (CAPES, Brazil) [88887.481152/2020-00]; Vinnova [2020-00377, 2020-01944] Funding Source: Vinnova FX L.F. Barbisan was the recipient of a fellowship from the Sao Paulo Research Foundation (FAPESP, Brazil; Grant: #2020/01078-7). Gabriel Bacil and Guilherme R. Romualdo were the recipients of scholarships from the FAPESP (Grants #2020/01944-6 and #2020/00377-0, respectively) and Coordination of Superior Level Staff Improvement (CAPES, Brazil; Grant #88887.481152/2020-00) for G.P.B. 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PD AUG 15 PY 2022 VL 13 IS 16 BP 8348 EP 8362 DI 10.1039/d2fo01488b EA JUL 2022 PG 15 WC Biochemistry & Molecular Biology; Food Science & Technology WE Science Citation Index Expanded (SCI-EXPANDED) SC Biochemistry & Molecular Biology; Food Science & Technology GA 3T7HR UT WOS:000831276200001 PM 35899794 DA 2026-02-02 ER PT J AU Fernando, DH Forbes, JM Angus, PW Herath, CB AF Fernando, Dinali H. Forbes, Josephine M. Angus, Peter W. Herath, Chandana B. TI Development and Progression of Non-Alcoholic Fatty Liver Disease: The Role of Advanced Glycation End Products SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES LA English DT Review DE advanced glycation end products; hepatic Kuppfer cells; hepatic stellate cells; non-alcoholic fatty liver disease; oxidative stress; receptor for advanced glycation end products ID HEPATIC STELLATE CELLS; OXIDATIVE STRESS; KUPFFER CELLS; MEDITERRANEAN DIET; ELEVATED LEVELS; RECEPTOR; RAGE; ACTIVATION; INFLAMMATION; ENDPRODUCTS AB Non-alcoholic fatty liver disease (NAFLD) affects up to 30% of the adult population and is now a major cause of liver disease-related premature illness and deaths in the world. Treatment is largely based on lifestyle modification, which is difficult to achieve in most patients. Progression of simple fatty liver or steatosis to its severe form non-alcoholic steatohepatitis (NASH) and liver fibrosis has been explained by a 'two-hit hypothesis'. Whilst simple steatosis is considered the first hit, its transformation to NASH may be driven by a second hit. Of several factors that constitute the second hit, advanced glycation end products (AGEs), which are formed when reducing-sugars react with proteins or lipids, have been implicated as major candidates that drive steatosis to NASH via the receptor for AGEs (RAGE). Both endogenous and processed food-derived (exogenous) AGEs can activate RAGE, mainly present on Kupffer cells and hepatic stellate cells, thus propagating NAFLD progression. This review focuses on the pathophysiology of NAFLD with special emphasis on the role of food-derived AGEs in NAFLD progression to NASH and liver fibrosis. Moreover, the effect of dietary manipulation to reduce AGE content in food or the therapies targeting AGE/RAGE pathway on disease progression is also discussed. C1 [Fernando, Dinali H.; Herath, Chandana B.] Univ Melbourne, Dept Med, Melbourne, Vic 3084, Australia. [Forbes, Josephine M.] Univ Queensland, Mater Inst, Brisbane, Qld 4102, Australia. [Angus, Peter W.] Austin Hlth, Liver Transplant Unit, Heidelberg, Vic 3084, Australia. C3 University of Melbourne; University of Queensland; Mater Research; Florey Institute of Neuroscience & Mental Health; Howard Florey Institute Affiliates; Austin Research Institute RP Herath, CB (通讯作者)，Univ Melbourne, Dept Med, Melbourne, Vic 3084, Australia. EM hettiyaf@student.unimelb.edu.au; Josephine.Forbes@mater.uq.edu.au; Peter.Angus@austin.org.au; cherath@unimelb.edu.au RI Forbes, Josephine/A-4569-2012; Herath, Chandana/AAT-3251-2021 FU National Health and Medical Research Council (NHMRC) of Australia [APP1029990] FX This work was supported by National Health and Medical Research Council (NHMRC) of Australia project grant (APP1029990). 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J. Mol. Sci. PD OCT 2 PY 2019 VL 20 IS 20 AR 5037 DI 10.3390/ijms20205037 PG 19 WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary WE Science Citation Index Expanded (SCI-EXPANDED) SC Biochemistry & Molecular Biology; Chemistry GA JQ3AZ UT WOS:000498822800069 PM 31614491 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Agosti, P Sabbà, C Mazzocca, A AF Agosti, Pasquale Sabba, Carlo Mazzocca, Antonio TI Emerging metabolic risk factors in hepatocellular carcinoma and their influence on the liver microenvironment SO BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE LA English DT Review DE Hepatocellular carcinoma (HCC); Non-alcoholic fatty liver disease (NAFLD); Nonalcoholic steatohepatitis (NASH); Liver microenvironment; Inflammation; Insulin resistance ID ALPHA GENE-EXPRESSION; FATTY LIVER; NONALCOHOLIC STEATOHEPATITIS; GUT MICROBIOTA; INTESTINAL MICROBIOTA; URSODEOXYCHOLIC ACID; MEDITERRANEAN DIET; INSULIN-RESISTANCE; DIABETES-MELLITUS; HEPATIC STEATOSIS AB Despite the reducing incidence of chronic hepatitis infections, an unexpected increasing incidence of hepatocellular carcinoma (HCC) has being occurred. This may be explained by the increasing number of HCCs developing on steatosis (NAFLD) and steatohepatitis (NASH), related to metabolic risk factors (i.e. diabetes mellitus type II, obesity, metabolic syndrome), which are becoming emerging risk factors for HCC. This led to a growing scientific interest on the oncogenic mechanisms underlying the transition from NAFLD to HCC. However, patients with NASH receive significantly less HCC surveillance than patients with chronic hepatitis, and no specific preventive pharmacological treatments have recommended for NASH-related HCC. This review focuses on the pathogenic role of the emerging factors involved in the transition from NAFLD/NASH to HCC, including microbiota, insulin resistance, inflammation, lipid and bile acids metabolism. It will be emphasize their impact on the liver microenvironment, the implications in clinical practice and the future directions of research. C1 [Agosti, Pasquale; Sabba, Carlo; Mazzocca, Antonio] Univ Bari, Interdisciplinary Dept Med, Sch Med, Piazza G Cesare 11, I-70124 Bari, Italy. C3 Universita degli Studi di Bari Aldo Moro RP Mazzocca, A (通讯作者)，Univ Bari, Interdisciplinary Dept Med, Sch Med, Piazza G Cesare 11, I-70124 Bari, Italy. EM antonio.mazzocca@uniba.it RI Agosti, Pasquale/L-3148-2019; MAZZOCCA, Antonio/AAD-7507-2021 OI Agosti, Pasquale/0000-0002-1239-775X; MAZZOCCA, Antonio/0000-0003-0940-7352 FU AIRC (Italian Association for Cancer Research) Investigator Grant (IG) [17758] FX The work was supported by AIRC (Italian Association for Cancer Research) Investigator Grant (IG) 2015 Id.17758 (to A. Mazzocca). 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10.1002/hep.24544 Zhu LX, 2013, HEPATOLOGY, V57, P601, DOI 10.1002/hep.26093 NR 100 TC 48 Z9 56 U1 1 U2 22 PU ELSEVIER PI AMSTERDAM PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS SN 0925-4439 EI 1879-260X J9 BBA-MOL BASIS DIS JI Biochim. 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PD FEB PY 2018 VL 1864 IS 2 BP 607 EP 617 DI 10.1016/j.bbadis.2017.11.026 PG 11 WC Biochemistry & Molecular Biology; Biophysics; Cell Biology WE Science Citation Index Expanded (SCI-EXPANDED) SC Biochemistry & Molecular Biology; Biophysics; Cell Biology GA FU8AN UT WOS:000424074300027 PM 29197664 OA Green Submitted DA 2026-02-02 ER PT J AU Huang, T Behary, J Zekry, A AF Huang, Tony (Dazhong) Behary, Jason Zekry, Amany TI Non-alcoholic fatty liver disease: a review of epidemiology, risk factors, diagnosis and management SO INTERNAL MEDICINE JOURNAL LA English DT Review DE non-alcoholic fatty liver disease; non-alcoholic steatohepatitis; liver cirrhosis; hepatocellular carcinoma ID BODY-MASS INDEX; HEPATOCELLULAR-CARCINOMA; MEDITERRANEAN DIET; BARIATRIC SURGERY; NATURAL-HISTORY; NAFLD; TRANSPLANTATION; STEATOHEPATITIS; PATHOPHYSIOLOGY; ASSOCIATION AB Due to the rising prevalence of obesity and type II diabetes mellitus, non-alcoholic fatty liver disease is becoming the leading cause of chronic liver disease in the Western world. In some patients, simple steatosis can result in non-alcoholic steatohepatitis which over time can lead to liver cirrhosis and its associated sequelae, including hepatocellular carcinoma. Early identification and management of patients at risk with intensive dietary and lifestyle modification are essential to prevent the development of advanced liver disease and its complications. In this review, we will discuss the epidemiology of non-alcoholic fatty liver disease, pathogenesis, diagnosis, management and surveillance strategies to offset the morbidity and mortality of this disease, as well as liver and non-liver-related complications. C1 [Huang, Tony (Dazhong); Behary, Jason; Zekry, Amany] St George Hosp, Dept Gastroenterol & Hepatol, Sydney, NSW, Australia. [Huang, Tony (Dazhong); Behary, Jason; Zekry, Amany] UNSW Sydney, St George & Sutherland Clin Sch, Sydney, NSW, Australia. C3 St George Hospital; University of New South Wales Sydney RP Huang, T (通讯作者)，St George Hosp, Dept Gastroenterol & Hepatol, Gray St, Kogarah, NSW 2217, Australia. EM dazhong.huang@health.nsw.gov.au RI zekry, amany/ABC-9995-2020 OI ZEKRY, AMANY/0000-0002-5675-1810; Huang, Dazhong/0000-0003-4698-0799 CR Adams LA, 2008, J GASTROEN HEPATOL, V23, P1089, DOI 10.1111/j.1440-1746.2008.05451.x Anania C, 2018, WORLD J GASTROENTERO, V24, P2083, DOI 10.3748/wjg.v24.i19.2083 Angulo P, 2007, HEPATOLOGY, V45, P846, DOI 10.1002/hep.21496 [Anonymous], 2017, Obesity Update 2017, DOI DOI 10.1007/S11428-017-0241-7 Association TGSoAAL, 2012, Economic cost of incontinence in Australia Internet Australian Bureau of Statistics, 2017, NAT HLTH SURV 1 RES Ayonrinde OT, 2011, HEPATOLOGY, V53, P800, DOI 10.1002/hep.24097 Berentzen TL, 2014, J HEPATOL, V60, P325, DOI 10.1016/j.jhep.2013.09.015 Birkenfeld AL, 2014, HEPATOLOGY, V59, P713, DOI 10.1002/hep.26672 Boyd A, 2020, FRONTLINE GASTROENTE, V11, P40, DOI 10.1136/flgastro-2018-101139 Bravo AA, 2001, NEW ENGL J MED, V344, P495, DOI 10.1056/NEJM200102153440706 Caldwell SH, 1999, HEPATOLOGY, V29, P664, DOI 10.1002/hep.510290347 Cowin GJ, 2008, J MAGN RESON IMAGING, V28, P937, DOI 10.1002/jmri.21542 Dare AJ, 2014, LIVER TRANSPLANT, V20, P281, DOI 10.1002/lt.23818 Diehl AM, 2017, NEW ENGL J MED, V377, P2063, DOI 10.1056/NEJMra1503519 Duseja A, 2013, HEPATOL INT, V7, pS755, DOI 10.1007/s12072-013-9480-x Dyson JK, 2014, FRONTLINE GASTROENTE, V5, P277, DOI 10.1136/flgastro-2013-100404 Dyson J, 2014, J HEPATOL, V60, P110, DOI 10.1016/j.jhep.2013.08.011 Ekstedt Mattias, 2017, Curr Hepatol Rep, V16, P391, DOI [10.1007/s11901-017-0378-2, 10.1007/s11901-017-0378-2] Fiorucci S, 2018, PHARMACOL RES, V134, P289, DOI 10.1016/j.phrs.2018.07.014 Grundy SM, 2004, CIRCULATION, V109, P433, DOI 10.1161/01.CIR.0000112379.88385.67 Hernaez R, 2011, HEPATOLOGY, V54, P1082, DOI 10.1002/hep.24452 Jorgensen NB, 2012, AM J PHYSIOL-ENDOC M, V303, pE122, DOI 10.1152/ajpendo.00073.2012 Kolodziejczyk AA, 2019, EMBO MOL MED, V11, DOI 10.15252/emmm.201809302 Kontogianni MD, 2014, CLIN NUTR, V33, P678, DOI 10.1016/j.clnu.2013.08.014 Lassailly G, 2015, GASTROENTEROLOGY, V149, P379, DOI 10.1053/j.gastro.2015.04.014 Laursen TL, 2019, WORLD J HEPATOL, V11, P138, DOI 10.4254/wjh.v11.i2.138 Lee Y, 2019, CLIN GASTROENTEROL H, V17, P1040, DOI 10.1016/j.cgh.2018.10.017 Leoni S, 2018, WORLD J GASTROENTERO, V24, P3361, DOI 10.3748/wjg.v24.i30.3361 Lindenmeyer CC, 2018, CLIN LIVER DIS, V22, P11, DOI 10.1016/j.cld.2017.08.003 Loomba R, 2013, NAT REV GASTRO HEPAT, V10, P686, DOI 10.1038/nrgastro.2013.171 Ma Irene T, 2015, Gastroenterol Hepatol (N Y), V11, P526 Mahady SE, 2018, J GASTROEN HEPATOL, V33, P1, DOI 10.1111/jgh.14270 Malik SM, 2009, LIVER TRANSPLANT, V15, P1843, DOI 10.1002/lt.21943 Marchesini G, 2017, J HEPATOL, V66, P466, DOI 10.1016/j.jhep.2016.11.002 Marra F, 2013, CURR PHARM DESIGN, V19, P5250, DOI 10.2174/13816128113199990344 Martin P, 2014, HEPATOLOGY, V59, P1144, DOI 10.1002/hep.26972 McPherson S, 2010, GUT, V59, P1265, DOI 10.1136/gut.2010.216077 Michelotti GA, 2013, NAT REV GASTRO HEPAT, V10, P656, DOI 10.1038/nrgastro.2013.183 Mohamad B, 2016, HEPATOL INT, V10, P632, DOI 10.1007/s12072-015-9679-0 Musso G, 2012, DIABETOLOGIA, V55, P885, DOI 10.1007/s00125-011-2446-4 Nasr P, 2018, HEPATOL COMMUN, V2, P199, DOI 10.1002/hep4.1134 Pais R, 2016, J HEPATOL, V65, P1245, DOI 10.1016/j.jhep.2016.07.033 Pais R, 2013, J HEPATOL, V59, P550, DOI 10.1016/j.jhep.2013.04.027 Paschos P, 2009, HIPPOKRATIA, V13, P9 Patel YA, 2016, DIGEST DIS SCI, V61, P1406, DOI 10.1007/s10620-016-4035-3 Piscaglia F, 2016, HEPATOLOGY, V63, P827, DOI 10.1002/hep.28368 Safari Z, 2019, CELL MOL LIFE SCI, V76, P1541, DOI 10.1007/s00018-019-03011-w Sookoian S, 2017, CLIN MOL HEPATOL, V23, P1, DOI 10.3350/cmh.2016.0109 Stine JG, 2015, LIVER TRANSPLANT, V21, P1016, DOI 10.1002/lt.24134 Targher G, 2010, NEW ENGL J MED, V363, P1341, DOI 10.1056/NEJMra0912063 VanWagner LB, 2012, HEPATOLOGY, V56, P1741, DOI 10.1002/hep.25855 Wong RJ, 2014, HEPATOLOGY, V59, P2188, DOI 10.1002/hep.26986 Wong SW, 2018, JGH OPEN, V2, P235, DOI 10.1002/jgh3.12070 Yang KC, 2016, SCI REP-UK, V6, DOI 10.1038/srep27034 Yki-Järvinen H, 2014, LANCET DIABETES ENDO, V2, P901, DOI 10.1016/S2213-8587(14)70032-4 Younes R, 2018, J HEPATOL, V68, P326, DOI 10.1016/j.jhep.2017.10.006 NR 57 TC 162 Z9 194 U1 1 U2 57 PU WILEY PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1444-0903 EI 1445-5994 J9 INTERN MED J JI Intern. Med. J. PD SEP PY 2020 VL 50 IS 9 BP 1038 EP 1047 DI 10.1111/imj.14709 PG 10 WC Medicine, General & Internal WE Science Citation Index Expanded (SCI-EXPANDED) SC General & Internal Medicine GA NN7RB UT WOS:000568982600003 PM 31760676 DA 2026-02-02 ER PT J AU Tan, SY Georgousopoulou, EN Cardoso, BR Daly, RM George, ES AF Tan, Sze-Yen Georgousopoulou, Ekavi N. Cardoso, Barbara R. Daly, Robin M. George, Elena S. TI Associations between nut intake, cognitive function and non-alcoholic fatty liver disease (NAFLD) in older adults in the United States: NHANES 2011-14 SO BMC GERIATRICS LA English DT Article DE Nuts; Older adults; Cognition; Non-alcoholic fatty liver disease; Metabolic-associated fatty liver disease; Diet quality ID QUALITY-OF-LIFE; MEDITERRANEAN DIET; CARDIOVASCULAR-DISEASE; WEIGHT-GAIN; FOOD-INTAKE; CONSUMPTION; HEALTH; INDEX; SUPPLEMENTATION; BENEFITS AB BackgroundNuts are nutrient-rich and reported to provide some cognitive and cardiometabolic health benefits, but limited studies have focused on older adults. This study investigated the cross-sectional relationship between habitual nut intake, dietary pattern and quality, cognition and non-alcoholic fatty liver disease (NAFLD) in older adults.MethodsOlder adults (>= 60 years) from the NHANES 2011-12 and 2013-14 cohorts, who had complete data on cognitive function (as CERAD total, delayed recall, animal fluency and digit-symbol substitution test) and variables to calculate the Fatty Liver Index (FLI), an indicator of NAFLD, were included (n=1848). Nut intake and diet quality (Healthy Eating Index 2015) were determined using two 24-hour diet recalls. Participants were categorised into one of four groups based on their habitual nut intake: non-consumers (0 g/d), low intake (0.1-15.0 g/d), moderate intake (15.1-30.0 g/d) or met recommendation (>30 g/d), with all outcomes compared between these nut intake groups.ResultsCognitive scores of older adults were the lowest in non-consumers and significantly highest in the moderate intake group, with no further increase in those who consumed nuts more than 30 g/d (p<0.007). FLI was the lowest among older adults with moderate nut intake but the associations disappeared after adjusting for covariates (p=0.329). Moderate nut intake was also associated with better immediate and delayed memory in older adults with high risk of NAFLD (FLI60) (B=1.84 and 1.11, p<0.05 respectively). Higher nutrient intake and better diet quality (p<0.001) were seen with higher nut intake but did not influence energy from saturated fat intake. Factor analysis revealed 'Nuts and oils' as one of the four major dietary patterns associated with better cognition and lower FLI scores.ConclusionsModerate nut intake (15.1-30.0 g/d) may be sufficient for better cognitive performance, but not NAFLD risk of older adults in the US. C1 [Tan, Sze-Yen; Daly, Robin M.; George, Elena S.] Deakin Univ, Sch Exercise & Nutr Sci, Inst Phys Act & Nutr IPAN, Geelong, Vic 3220, Australia. [Georgousopoulou, Ekavi N.] Univ Notre Dame Australia, Sch Med Sydney, Sydney, NSW 2010, Australia. [Cardoso, Barbara R.] Monash Univ, Dept Nutr Dietet & Food, Clayton, Vic 3168, Australia. C3 Deakin University; The University of Notre Dame Australia; University of Notre Dame Australia - Sydney; Monash University RP Tan, SY (通讯作者)，Deakin Univ, Sch Exercise & Nutr Sci, Inst Phys Act & Nutr IPAN, Geelong, Vic 3220, Australia. EM szeyen.tan@deakin.edu.au RI George, Elena/J-3357-2019; Tan, Sze-Yen/H-5796-2019; Georgousopoulou, Ekavi/AAC-2563-2019; Daly, Robin/AAN-2353-2020; Rita Cardoso, Barbara/Q-8280-2016 OI George, Elena/0000-0002-1385-2371; Tan, Sze-Yen/0000-0002-9607-202X; Georgousopoulou, Ekavi/0000-0002-0592-3838; Rita Cardoso, Barbara/0000-0002-6393-1377 FU International Nut and Dried Fruit Council (INC) [2019-R02] FX This study was funded by the International Nut and Dried Fruit Council (INC) (Project number 2019-R02). The funder had no role in the design, analysis, interpretation of data, or writing of this article. 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PD MAY 17 PY 2021 VL 21 IS 1 AR 313 DI 10.1186/s12877-021-02239-1 PG 12 WC Geriatrics & Gerontology; Gerontology WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI) SC Geriatrics & Gerontology GA SK5SO UT WOS:000656275100003 PM 34001034 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Ogawa, Y Yoneda, M Kobayashi, T Honda, Y Kessoku, T Imajo, K Saito, S Nakajima, A AF Ogawa, Yuji Yoneda, Masato Kobayashi, Takashi Honda, Yasushi Kessoku, Takaomi Imajo, Kento Saito, Satoru Nakajima, Atsushi TI Present and emerging pharmacotherapies for non-alcoholic steatohepatitis in adults SO EXPERT OPINION ON PHARMACOTHERAPY LA English DT Review DE Non-alcoholic fatty liver disease; non-alcoholic steatohepatitis; pharmacologic therapy; clinical trial ID FATTY LIVER-DISEASE; PAN-CASPASE INHIBITOR; BILE-ACID TRANSPORTERS; HEPATOCELLULAR-CARCINOMA; AMERICAN ASSOCIATION; OBETICHOLIC ACID; THYROID-HORMONE; VITAMIN-E; PRACTICE GUIDELINES; INSULIN-RESISTANCE AB Introduction: Multiple parallel factors are implicated in the pathogenesis and progression of non-alcoholic fatty liver disease (NAFLD)/non-alcoholic steatohepatitis (NASH). Currently recommended therapies for NASH include vitamin E and pioglitazone, besides dietary and lifestyle changes. Areas covered: This review focuses on the clinical development of several emerging drugs for the treatment of NASH and the impact of these drugs on current treatment standards. Expert opinion: Four drug classes (FXR agonists, CCR2/CCR5 antagonists, ASK1 inhibitors, and PPAR alpha/delta agonists) have moved into phase 3 trials for their investigation as NASH treatments. Results from phase 2 trials of other therapeutic agents with other pharmacological actions are also expected. The importance of combinational therapies with synergistic benefits engaging different targets, is now understood. Furthermore, studies have determined that the Mediterranean diet is beneficial for patients with NAFLD, while the traditional Okinawan diet is also considered useful. In the future, it will be important to establish new biomarkers to assess NAFLD activity, furthermore non-invasive diagnostic methods will promote the development of new drugs for NASH. C1 [Ogawa, Yuji; Yoneda, Masato; Kobayashi, Takashi; Honda, Yasushi; Kessoku, Takaomi; Imajo, Kento; Saito, Satoru; Nakajima, Atsushi] Yokohama City Univ, Grad Sch Med, Dept Gastroenterol & Hepatol, Yokohama, Kanagawa, Japan. C3 Yokohama City University RP Nakajima, A (通讯作者)，Yokohama City Univ, Grad Sch Med, Dept Gastroenterol & Hepatol, Kanazawa Ku, 3-9 Fukuura, Yokohama, Kanagawa 2360004, Japan. EM nakajima-tky@umin.ac.jp RI Kobayashi, Takashi/OON-9747-2025; Imajo, Kento/AAF-5744-2020 OI Kobayashi, Takashi/0000-0002-7240-4851; FU Japan Society for the Promotion of Science KAKENHI [18K07637]; Grants-in-Aid for Scientific Research [18K07637] Funding Source: KAKEN FX The authors were supported by a grant from the Japan Society for the Promotion of Science KAKENHI 18K07637. 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PD JAN 2 PY 2019 VL 20 IS 1 BP 69 EP 82 DI 10.1080/14656566.2018.1543403 PG 14 WC Pharmacology & Pharmacy WE Science Citation Index Expanded (SCI-EXPANDED) SC Pharmacology & Pharmacy GA HF8WC UT WOS:000454521900009 PM 30411635 DA 2026-02-02 ER PT J AU Martinez-Urbistondo, D San Cristobal, R Villares, P Martínez-González, MA Babio, N Corella, D del Val, JL Ordovas, JM Alonso-Gomez, AM Warnberg, J Vioque, J Romaguera, D Lopez-Miranda, J Estruch, R Tinahones, FJ Lapetra, J Serra-Majem, JL Bueno-Cavanillas, A Tur, JA Marcos, A Pinto, X Delgado-Rodriguez, M Matia-Martin, P Vidal, J Vazquez, C Ros, E Vela, MVB Palau, A Masague, M Abete, I Moreno-Rodriguez, A Candela-Garcia, I Konieczna, J Garcia-Rios, A Juarez, OL Martin, P Goday, A Zulet, MA Vaquero-Luna, J Orea, MDS Megias, I Baltasar, E Martinez, JA Daimiel, L AF Martinez-Urbistondo, Diego San Cristobal, RodrigoSan Villares, Paula Martinez-Gonzalez, Miguel Angel Babio, Nancy Corella, Dolores del Val, Jose Luis Ordovas, Jose M. Alonso-Gomez, Angel M. Warnberg, Julia Vioque, Jesus Romaguera, Dora Lopez-Miranda, Jose Estruch, Ramon Tinahones, Francisco J. Lapetra, Jose Serra-Majem, J. Luis Bueno-Cavanillas, Aurora Tur, Josep A. Marcos, Alba Pinto, Xavier Delgado-Rodriguez, Miguel Matia-Martin, Pilar Vidal, Josep Vazquez, Clotilde Ros, Emilio Vela, Maria Vanessa Bullon Palau, Antoni Masague, Marta Abete, Itziar Moreno-Rodriguez, Anai Candela-Garcia, Inma Konieczna, Jadwiga Garcia-Rios, Antonio Juarez, Oscar Lecea Martin, Paco Goday, Albert Zulet, M. Angeles Vaquero-Luna, Jessica Orea, Maria del Carmen Sayon Megias, Isabel Baltasar, Enric Martinez, J. Alfredo Daimiel, Lidia TI Role of NAFLD on the Health Related QoL Response to Lifestyle in Patients With Metabolic Syndrome: The PREDIMED Plus Cohort SO FRONTIERS IN ENDOCRINOLOGY LA English DT Article DE NAFLD; metabolic syndrome; mediterranean diet; physical activity; HRQoL ID QUALITY-OF-LIFE; MEDITERRANEAN DIET AB ObjectiveTo evaluate the effect of Non-alcoholic fatty liver disease (NAFLD) status in the impact of lifestyle over Health-related quality of life (HRQoL) in patients with metabolic syndrome (MetS). MethodsBaseline and 1 year follow up data from the PREDIMED-plus cohort (men and women, 55-75 years old with overweight/obesity and MetS) were studied. Adherence to an energy-restricted Mediterranean Diet (er-MeDiet) and Physical Activity (PA) were assessed with a validated screeners. Hepatic steatosis index (HSI) was implemented to evaluate NAFLD while the SF-36 questionnaire provided HRQoL evaluation. Statistical analyses were performed to evaluate the influence of baseline NAFLD on HRQoL as affected by lifestyle during 1 year of follow up. ResultsData from 5205 patients with mean age of 65 years and a 48% of female participants. Adjusted linear multivariate mixed regression models showed that patients with lower probability of NAFLD (HSI < 36 points) were more responsive to er-MeDiet (beta 0.64 vs beta 0.05 per er-MeDiet adherence point, p< 0.01) and PA (beta 0.05 vs beta 0.01 per MET-h/week, p = 0.001) than those with high probability for NAFLD in terms Physical SF-36 summary in the 1 year follow up. 10 points of er-MeDiet adherence and 50 MET-h/week were thresholds for a beneficial effect of lifestyle on HRQoL physical domain in patients with lower probability of NAFLD. ConclusionThe evaluation of NAFLD by the HSI index in patients with MetS might identify subjects with different prospective sensitivity to lifestyle changes in terms of physical HRQoL (http://www.isrctn.com/ISRCTN89898870). C1 [Martinez-Urbistondo, Diego; Villares, Paula] HM Hosp, Hosp HM Sanchinarro, Internal Med Dept, Madrid, Spain. [San Cristobal, RodrigoSan; Martinez, J. Alfredo] Univ Autonoma Madrid UAM, Ctr Excelencia Invest CEI, Ctr Super Invest Cient CSIC, Cardiometab Nutr Grp,Inst Madrileno Estudios Avanz, Madrid, Spain. [Martinez-Gonzalez, Miguel Angel; Vela, Maria Vanessa Bullon; Juarez, Oscar Lecea; Orea, Maria del Carmen Sayon] Univ Navarra, Dept Prevent Med & Publ Hlth, IdiSNA, Pamplona, Spain. [Martinez-Gonzalez, Miguel Angel; Babio, Nancy; Corella, Dolores; del Val, Jose Luis; Alonso-Gomez, Angel M.; Warnberg, Julia; Romaguera, Dora; Lopez-Miranda, Jose; Estruch, Ramon; Tinahones, Francisco J.; Lapetra, Jose; Serra-Majem, J. Luis; Tur, Josep A.; Pinto, Xavier; Vazquez, Clotilde; Ros, Emilio; Vela, Maria Vanessa Bullon; Palau, Antoni; Masague, Marta; Abete, Itziar; Moreno-Rodriguez, Anai; Konieczna, Jadwiga; Garcia-Rios, Antonio; Juarez, Oscar Lecea; Martin, Paco; Goday, Albert; Zulet, M. Angeles; Vaquero-Luna, Jessica; Orea, Maria del Carmen Sayon; Megias, Isabel; Baltasar, Enric; Martinez, J. Alfredo] Inst Salud Carlos III ISCIII, Consorcio CIBER, MP Fisiopatol Obes & Nutr CIBERObn, Madrid, Spain. [Martinez-Gonzalez, Miguel Angel] Harvard T H Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA. [Babio, Nancy; Palau, Antoni; Martin, Paco; Megias, Isabel] Univ Rovira & Virgili, Dept Bioquim & Biotecnol, Unitat Nutr Humana, Reus, Spain. [Babio, Nancy; Palau, Antoni; Martin, Paco; Megias, Isabel] Hosp Univ San Joan De Reus, Inst Invest Sanitaria Pere Virgili IISPV, Human Nutr Unit, Reus, Spain. [Corella, Dolores] Univ Valencia, Dept Prevent Med, Valencia, Spain. [del Val, Jose Luis; Masague, Marta; Goday, Albert; Baltasar, Enric] Hosp Del Mar Med Res Inst IMIM, Cardiovasc Risk & Nutr Res Grp CARIN, Barcelona, Spain. [Ordovas, Jose M.] Univ Autonoma Madrid UAM, Ctr Excelencia Invest CEI, Ctr Super Invest Cient CSIC, Nutr Genom & Epigen Grp,Inst Madrileno Estudios Av, Madrid, Spain. [Ordovas, Jose M.] Tufts Univ, Nutr & Genom Lab, Jean Mayer united States Dept Agr JM USDA, Human Nutr Res Ctr Aging, Boston, MA USA. [Alonso-Gomez, Angel M.; Moreno-Rodriguez, Anai; Vaquero-Luna, Jessica] Univ Basque Country Univ Pais Vasco Euskal Herriko, Araba Univ Hosp, Bioaraba Hlth Res Inst, Osakidetza Basque Hlth Serv, Vitoria, Spain. [Warnberg, Julia; Bueno-Cavanillas, Aurora; Delgado-Rodriguez, Miguel] Univ Malaga, Sch Hlth Sci, Dept Nursing, Inst Invest Biomed Malaga IBIMA, Malaga, Spain. [Vioque, Jesus; Marcos, Alba] Inst Salud Carlos III, Ctr Invest Biomed Red Epidemiol & Salud Publ CIBER, Madrid, Spain. [Vioque, Jesus] Univ Miguel Hernandez ISABIAL UMH, Inst Invest Sanitaria & Biomed Alicante, Alicante, Spain. [Romaguera, Dora; Konieczna, Jadwiga] Univ Hosp Son Espases HUSE, Hlth Res Inst Balear Isl IdISBa, Res Grp Nutr Epidemiol & Cardiovasc Physiopathol N, Palma De Mallorca, Spain. [Lopez-Miranda, Jose; Garcia-Rios, Antonio] Univ Cordoba, Reina Sofia Univ Hosp, Maimonides Biomed Res Inst Cordoba IMIBIC, Dept Internal Med,Lipids & Atherosclerosis Unit, Cordoba, Spain. [Estruch, Ramon] Univ Barcelona, Hosp Clin, Dept Internal Med, Inst Invest Biomed August Pi & Sunyer IDIBAPS, Barcelona, Spain. [Tinahones, Francisco J.] Univ Malaga, Virgen Victoria Hosp, Dept Endocrinol, Inst Invest Biomed Malaga IBIMA, Malaga, Spain. [Lapetra, Jose] Dist Sanitario Atenc Primaria Sevilla, Dept Family Med, Res Unit, Seville, Spain. [Serra-Majem, J. Luis] Univ Las Palmas Gran Canaria, Inst Univ Invest Biomed & Sanitarias IUIBS, Ctr Hosp Univ Insular Materno Infantil CHUIMI, Res Inst Biomed & Hlth Sci,Canarian Hlth Serv,Prev, Las Palmas Gran Canaria, Spain. [Bueno-Cavanillas, Aurora] Univ Granada, Dept Prevent Med & Publ Hlth, Granada, Spain. [Tur, Josep A.] Univ Balearic Isl, Res Grp Community Nutr & Oxidat Stress, Palma De Mallorca, Spain. [Marcos, Alba] Univ Leon, Inst Biomed IBIOMED, Leon, Spain. [Pinto, Xavier] Hosp Univ Bellvitge, Lipids & Vasc Risk Unit, Internal Med, Barcelona, Spain. [Delgado-Rodriguez, Miguel] Univ Jaen, Ctr Estudios Avanzados Olivar & Aceites Oliva, Dept Ciencias Salud, Jaen, Spain. [Matia-Martin, Pilar] Inst Invest Sanitaria Hosp Clin San Carlos IdISSC, Dept Endocrinol & Nutr, Madrid, Spain. [Vidal, Josep] Inst Salud Carlos III ISCIII, Biomed Res Ctr Diabet & Metab Dis Network CIBERDEM, Madrid, Spain. [Vidal, Josep; Ros, Emilio] Univ Barcelona, Hosp Clin, Endocrinol & Nutr Serv, Inst Invest Biomed August Pi & Sunyer IDIBAPS, Barcelona, Spain. [Vazquez, Clotilde] Univ Autonoma, Hosp Fdn Jimenez Diaz, Dept Endocrinol & Nutr, Inst Invest Biomed IISFJD, Madrid, Spain. [Abete, Itziar; Zulet, M. Angeles; Martinez, J. Alfredo] Univ Navarra, Dept Nutr Food Sci & Physiol, Pamplona, Spain. [Candela-Garcia, Inma] Ctr Salud San Pola, Alicante, Spain. [Goday, Albert] Univ Autonoma Barcelona, Dept Med, Barcelona, Spain. [Daimiel, Lidia] Univ Autonoma Madrid UAM, Ctr Excelencia Invest CEI, Ctr Super Invest Cient CSIC, Nutr Control Epigenome Grp,Precis Nutr & Obes Prog, Madrid, Spain. C3 University of Navarra; Harvard University; Harvard T.H. Chan School of Public Health; Universitat Rovira i Virgili; Universitat Rovira i Virgili; Institut d'Investigacio Sanitaria Pere Virgili (IISPV); University of Valencia; Hospital del Mar Research Institute; Hospital del Mar; United States Department of Agriculture (USDA); Tufts University; Bioaraba Health Research Institute; University Hospital of Araba; Universidad de Malaga; IBIMA Plataforma BIONAND, Instituto de Investigacion Biomedica de Malaga; Instituto de Salud Carlos III; General University Hospital of Alicante; Universidad Miguel Hernandez de Elche; Universitat d'Alacant; Instituto de Investigacion Sanitaria y Biomedica de Alicante (ISABIAL); Institut Investigacio Sanitaria Illes Balears (IdISBa); Hospital Universitari Son Espases; Universidad de Cordoba; University of Barcelona; Hospital Clinic de Barcelona; IDIBAPS; Universidad de Malaga; IBIMA Plataforma BIONAND, Instituto de Investigacion Biomedica de Malaga; Universidad de Las Palmas de Gran Canaria; University of Granada; Universitat de les Illes Balears; Universidad de Leon; University of Barcelona; Institut d'Investigacio Biomedica de Bellvitge (IDIBELL); Bellvitge University Hospital; Universidad de Jaen; University of Barcelona; Hospital Clinic de Barcelona; IDIBAPS; Autonomous University of Madrid; Fundacion Jimenez Diaz; University of Navarra; Autonomous University of Barcelona RP Martinez-Urbistondo, D (通讯作者)，HM Hosp, Hosp HM Sanchinarro, Internal Med Dept, Madrid, Spain. EM Dmurbistondo@gmail.com RI Delgado Rodríguez, Miguel/KCZ-1828-2024; del Val García, José Luis/G-6195-2016; Warnberg, Julia/G-1390-2011; Estruch, Ramon/AAZ-3723-2020; San-Cristobal, Roigo/R-5992-2018; Pintó, Xavier/AGI-4297-2022; Vidal, Josep/MIK-6936-2025; Romaguera, Dora/ABE-7004-2020; Martinez-Gonzalez, Miguel/AAE-7669-2019; Bueno-Cavanillas, Aurora/O-1513-2015; Lopez-Miranda, Jose/Y-8306-2019; Corella, Dolores/L-9888-2014; BABIO SÁNCHEZ, NANCY/AAN-2715-2020; Lapetra, Jose/F-2552-2015; Tinahones, Francisco J/AAB-2882-2020; Tur, Josep/AAE-5748-2020; Vioque, Jesus/A-1066-2008; Daimiel-Ruiz, Lidia/M-7779-2014; Martínez, J./K-8709-2014; Konieczna, Jadwiga/AAB-2817-2020; ALONSO GOMEZ, ANGEL/HLG-2476-2023 OI Delgado Rodríguez, Miguel/0000-0002-3838-2548; del Val García, José Luis/0000-0002-0391-9368; San-Cristobal, Roigo/0000-0001-8054-6553; Lopez-Miranda, Jose/0000-0002-8844-0718; Martínez-Urbistondo, Diego/0000-0002-0530-7349; BABIO SÁNCHEZ, NANCY/0000-0003-3527-5277; Tinahones, Francisco J/0000-0001-6871-4403; Vioque, Jesus/0000-0002-2284-148X; FU CIBER Fisiopatologia de la Obesidad y Nutricion (CIBEROBN); Instituto de Salud Carlos III (ISCIII) through the Fondo de Investigacion para la Salud (FIS); European Regional Development Fund [PI13/00673, PI13/00492, PI13/00272, PI13/01123, PI13/00462, PI13/00233, PI13/02184, PI13/00728, PI13/01090, PI13/01056, PI14/01722, PI14/00636, PI14/00618, PI14/00696, PI14/01206, PI14/01919, PI14/00853, PI14/01374, PI14/00972, PI14/00728, PI14/01471, PI16/00473, PI16/00662, PI16/01873, PI16/01094, PI16/00501, PI16/00533, PI16/00381, PI16/00366, PI16/01522, PI16/01120, PI17/00764, PI17/01183, PI17/00855, PI17/01347, PI17/00525, PI17/01827, PI17/00532, PI17/00215, PI17/01441, PI17/00508, PI17/01732, PI17/00926, PI19/00957, PI19/00386, PI19/00309, PI19/01032, PI19/00576, PI19/00017, PI19/01226, PI19/00781, PI19/01560, PI19/01332, PI20/01802, PI20/00138, PI20/01532, PI20/00456, PI20/00339, PI20/00557, PI20/00886, PI20/01158]; Special Action Project "Implementacion y evaluacion de una intervencion intensiva sobre la actividad fisica Cohorte PREDIMED-Plus"; Recercaixa [2013ACUP00194]; Consejeria de Salud de la Junta de Andalucia [PI0458/2013, PS0358/2016, PI0137/2018]; SEMERGEN grant; Department of Health of the Government of Navarra [61/201]; Fundacio La Marato de TV [201630.10]; European Research Council [340918]; Ministerio de Ciencia e Investigacion [RTI2018-095569-B-I00, PCI2018-093009]; [35/2011]; BBSRC [BB/S020845/1] Funding Source: UKRI FX The present study received funding from coordinated FIS project official Spanish institutions for funding scientific biomedical research, CIBER Fisiopatologia de la Obesidad y Nutricion (CIBEROBN) and Instituto de Salud Carlos III (ISCIII) through the Fondo de Investigacion para la Salud (FIS) which is co-funded by the European Regional Development Fund (including the following projects: PI13/00673, PI13/00492, PI13/00272, PI13/01123, PI13/00462, PI13/00233, PI13/02184, PI13/00728, PI13/01090, PI13/01056, PI14/01722, PI14/00636, PI14/00618, PI14/00696, PI14/01206, PI14/01919, PI14/00853, PI14/01374, PI14/00972, PI14/00728, PI14/01471, PI16/00473, PI16/00662, PI16/01873, PI16/01094, PI16/00501, PI16/00533, PI16/00381, PI16/00366, PI16/01522, PI16/01120, PI17/00764, PI17/01183, PI17/00855, PI17/01347, PI17/00525, PI17/01827, PI17/00532, PI17/00215, PI17/01441, PI17/00508, PI17/01732, PI17/00926, PI19/00957, PI19/00386, PI19/00309, PI19/01032, PI19/00576, PI19/00017, PI19/01226, PI19/00781, PI19/01560, PI19/01332, PI20/01802, PI20/00138, PI20/01532, PI20/00456, PI20/00339, PI20/00557, PI20/00886, PI20/01158), the Special Action Project "Implementacion y evaluacion de una intervencion intensiva sobre la actividad fisica Cohorte PREDIMED-Plus", the Recercaixa (grant number 2013ACUP00194) funding and the grants from the Consejeria de Salud de la Junta de Andalucia (PI0458/2013; PS0358/2016; PI0137/2018), the SEMERGEN grant; Department of Health of the Government of Navarra (61/2015), the Fundacio La Marato de TV (Ref. 201630.10), the coordinated grant supported by the European Research Council (Advanced Research grant 2014-2019; agreement #340918), the grant of support to research groups 35/2011 (Balearic Islands Government; FEDER funds). This study has been carried out thanks to the funds provided by Ministerio de Ciencia e Investigacion through grants from PROYECTOS DE I+D+I "RETOS INVESTIGACION" (RTI2018-095569-B-I00) and "PROGRAMACION CONJUNTA INTERNACIONAL" (PCI2018-093009). 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Endocrinol. PD JUN 29 PY 2022 VL 13 AR 868795 DI 10.3389/fendo.2022.868795 PG 11 WC Endocrinology & Metabolism WE Science Citation Index Expanded (SCI-EXPANDED) SC Endocrinology & Metabolism GA 3N2IZ UT WOS:000835976900001 PM 35846291 OA Green Submitted, Green Published, gold DA 2026-02-02 ER PT J AU Kitade, H Chen, GL Ni, YH Ota, T AF Kitade, Hironori Chen, Guanliang Ni, Yinhua Ota, Tsuguhito TI Nonalcoholic Fatty Liver Disease and Insulin Resistance: New Insights and Potential New Treatments SO NUTRIENTS LA English DT Review DE NAFLD/NASH; macrophage/Kupffer cells; chemokine; insulin resistance; inflammation; fibrosis; antioxidants; astaxanthin; beta-cryptoxanthin ID VITAMIN-E; ADIPOSE-TISSUE; MACROPHAGE PLASTICITY; MEDITERRANEAN DIET; HEPATIC STEATOSIS; OXIDATIVE STRESS; CHEMOATTRACTANT PROTEIN-1; ASTAXANTHIN PREVENTS; PLASMA ADIPONECTIN; BETA-CRYPTOXANTHIN AB Nonalcoholic fatty liver disease (NAFLD) is one of the most common chronic liver disorders worldwide. It is associated with clinical states such as obesity, insulin resistance, and type 2 diabetes, and covers a wide range of liver changes, ranging from simple steatosis to non-alcoholic steatohepatitis (NASH), liver cirrhosis, and hepatocellular carcinoma. Metabolic disorders, such as lipid accumulation, insulin resistance, and inflammation, have been implicated in the pathogenesis of NAFLD, but the underlying mechanisms, including those that drive disease progression, are not fully understood. Both innate and recruited immune cells mediate the development of insulin resistance and NASH. Therefore, modifying the polarization of resident and recruited macrophage/Kupffer cells is expected to lead to new therapeutic strategies in NAFLD. Oxidative stress is also pivotal for the progression of NASH, which has generated interest in carotenoids as potent micronutrient antioxidants in the treatment of NAFLD. In addition to their antioxidative function, carotenoids regulate macrophage/Kupffer cell polarization and thereby prevent NASH progression. In this review, we summarize the molecular mechanisms involved in the pathogenesis of NAFLD, including macrophage/Kupffer cell polarization, and disturbed hepatic function in NAFLD. We also discuss dietary antioxidants, such as beta-cryptoxanthin and astaxanthin, that may be effective in the prevention or treatment of NAFLD. C1 [Kitade, Hironori; Chen, Guanliang; Ni, Yinhua; Ota, Tsuguhito] Kanazawa Univ, Brain Liver Interface Med Res Ctr, Dept Cell Metab & Nutr, Kanazawa, Ishikawa 9208640, Japan. C3 Kanazawa University RP Ota, T (通讯作者)，Kanazawa Univ, Brain Liver Interface Med Res Ctr, Dept Cell Metab & Nutr, Kanazawa, Ishikawa 9208640, Japan. EM hiro.kitacchi@gmail.com; guanliangc@gmail.com; shali0145@gmail.com; tota@staff.kanazawa-u.ac.jp RI ; Yinhua, Ni/H-3079-2015 OI Chen, Guanliang/0000-0001-8790-2506; Yinhua, Ni/0000-0001-7738-5971 FU Ministry of Education, Culture, Sports, Science, Japan [16K18700, 25282017, 16H03035, 15K12698]; Research Project on Development of Agricultural Products and Foods with Health-Promoting Benefits (NARO) from Ministry of Agriculture, Forestry and Fisheries (MAFF) [2013-A-10]; Grants-in-Aid for Scientific Research [16K18700, 16H03035] Funding Source: KAKEN FX This work was supported by the following grants: Grant-in-Aid for Young Scientists (B) (16K18700) (Y.N.), Grant-in-Aid for Scientific Research (B) (25282017, 16H03035) (T.O.), and Challenging Exploratory Research (15K12698) (T.O.) from the Ministry of Education, Culture, Sports, Science, Japan; and Research Project on Development of Agricultural Products and Foods with Health-Promoting Benefits (NARO) (2013-A-10) (T.O.) from the Ministry of Agriculture, Forestry and Fisheries (MAFF). 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Zelber-Sagi, Shira Henry, Linda Gerber, Lynn H. TI Lifestyle interventions in nonalcoholic fatty liver disease SO NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY LA English DT Review ID GLYCATION END-PRODUCTS; MEDITERRANEAN DIET; PHYSICAL-ACTIVITY; GENETIC-VARIATION; WEIGHT-LOSS; CLINICAL CHARACTERISTICS; GLOBAL PREVALENCE; HEPATIC STEATOSIS; BUILT ENVIRONMENT; SOLUBLE RECEPTOR AB Nonalcoholic fatty liver disease (NAFLD) is a dynamic chronic liver disease that develops in close association with metabolic irregularities. Between 2016 and 2019, the global prevalence among adults was reported as 38% and among children and adolescents it was about 10%. NAFLD can be progressive and is associated with increased mortality from cardiovascular disease, extrahepatic cancers and liver complications. Despite these numerous adverse outcomes, no pharmacological treatments currently exist to treat nonalcoholic steatohepatitis, the progressive form of NAFLD. Therefore, the main treatment is the pursuit of a healthy lifestyle for both children and adults, which includes a diet rich in fruits, nuts, seeds, whole grains, fish and chicken and avoiding overconsumption of ultra-processed food, red meat, sugar-sweetened beverages and foods cooked at high heat. Physical activity at a level where one can talk but not sing is also recommended, including leisure-time activities and structured exercise. Avoidance of smoking and alcohol is also recommended. Policy-makers, community and school leaders need to work together to make their environments healthy by developing walkable and safe spaces with food stores stocked with culturally appropriate and healthy food items at affordable prices as well as providing age-appropriate and safe play areas in both schools and neighbourhoods. Nonalcoholic fatty liver disease (NALFD) prevalence, including in children and adolescents, is rising worldwide. This Review offers a comprehensive overview of the lifestyle interventions available for NAFLD, including dietary and physical-activity strategies. C1 [Younossi, Zobair M.; Henry, Linda; Gerber, Lynn H.] Inova Hlth Syst, Betty & Guy Beatty Ctr Integrated Res, Falls Church, VA 22042 USA. [Younossi, Zobair M.] Inova Fairfax Med Campus, Ctr Liver Dis, Dept Med, Falls Church, VA 22042 USA. [Younossi, Zobair M.; Henry, Linda; Gerber, Lynn H.] Inova Hlth Syst, Inova Med, Falls Church, VA 22042 USA. [Zelber-Sagi, Shira] Univ Haifa, Sch Publ Hlth, Haifa, Israel. C3 Inova Health System; Inova Fairfax Hospital; Inova Health System; University of Haifa RP Younossi, ZM (通讯作者)，Inova Hlth Syst, Betty & Guy Beatty Ctr Integrated Res, Falls Church, VA 22042 USA.; Younossi, ZM (通讯作者)，Inova Fairfax Med Campus, Ctr Liver Dis, Dept Med, Falls Church, VA 22042 USA.; Younossi, ZM (通讯作者)，Inova Hlth Syst, Inova Med, Falls Church, VA 22042 USA. 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Rev. Gastroenterol. Hepatol. PD NOV PY 2023 VL 20 IS 11 BP 708 EP 722 DI 10.1038/s41575-023-00800-4 EA JUL 2023 PG 15 WC Gastroenterology & Hepatology WE Science Citation Index Expanded (SCI-EXPANDED) SC Gastroenterology & Hepatology GA U9PU3 UT WOS:001023608300001 PM 37402873 HC Y HP N DA 2026-02-02 ER PT J AU Marusic, M Paic, M Knobloch, M Prso, AML AF Marusic, Marinko Paic, Matej Knobloch, Mia Liberati Prso, Ana-Marija TI NAFLD, Insulin Resistance, and Diabetes Mellitus Type 2 SO CANADIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY LA English DT Review ID NONALCOHOLIC FATTY LIVER; PLACEBO-CONTROLLED TRIAL; VITAMIN-E; GUT MICROBIOTA; MEDITERRANEAN DIET; REDUCES FEATURES; PROTEIN-KINASE; UNITED-STATES; LIFE-STYLE; DISEASE AB Nonalcoholic fatty liver disease is a condition defined by fat accumulation in hepatocytes not promoted by excessive alcohol consumption. It is highly prevalent and is strongly associated with insulin resistance, metabolic syndrome, and diabetes type II. Insulin resistance plays a crucial role in the multifactorial etiopathogenesis of this condition leading to accumulation of free fatty acids in the liver cells, thus causing lipotoxicity, inflammation, and fibrosis. In this review, we will focus on currently known pathogenesis of nonalcoholic fatty liver disease. Numerous investigation strategies are available to establish the diagnosis, from biochemical markers and ultrasound to various molecular and advanced imaging techniques and liver biopsy. Prevention is crucial. However, effective and promising therapies are strongly demanded. C1 [Marusic, Marinko; Paic, Matej; Knobloch, Mia] Univ Hosp Sveti Duh, Dept Haepatogastroenterol, Zagreb, Croatia. [Marusic, Marinko] JJ Strossmayer Univ Osijek, Fac Med, Osijek, Croatia. [Marusic, Marinko] Univ Rijeka, Fac Hlth Studies, Rijeka, Croatia. [Liberati Prso, Ana-Marija] Univ Hosp Sveti Duh, Dept Endocrinol & Diabetol, Zagreb, Croatia. 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PD FEB 17 PY 2021 VL 2021 AR 6613827 DI 10.1155/2021/6613827 PG 9 WC Gastroenterology & Hepatology WE Science Citation Index Expanded (SCI-EXPANDED) SC Gastroenterology & Hepatology GA QR0YW UT WOS:000624944800001 PM 33681089 OA Green Submitted, gold HC Y HP N DA 2026-02-02 ER PT J AU Di Lorenzo, M Pipicelli, L Aurino, L Sozio, C Palmiero, A Palmieri, D Lombardi, M Guida, B Santillo, M Lonardo, MS La Rosa, G Damiano, S AF Di Lorenzo, Mariana Pipicelli, Luca Aurino, Laura Sozio, Concetta Palmiero, Anna Palmieri, Domenico Lombardi, Marta Guida, Bruna Santillo, Mariarosaria Lonardo, Maria Serena La Rosa, Giuliana Damiano, Simona TI Effect of Nutraceutical Supplementation and Mediterranean Hypocaloric Diet on Calculated Steatosis Indices and Inflammation: Clinical and In Vitro Evidences SO MOLECULAR NUTRITION & FOOD RESEARCH LA English DT Article DE inflammation; leucoselect phytosome; NAFLD; nutraceutical supplementation; oxidative stress ID FATTY LIVER-DISEASE; GAMMA-GLUTAMYL-TRANSFERASE; OXIDATIVE STRESS; HEPG2 CELLS; OBESITY; SERUM; RISK; ACID; ASSOCIATIONS; POLICOSANOL AB This study evaluated the effect of a nutraceutical supplementation (NS) and Mediterranean hypocaloric diet (MHD) on hepatic steatosis indices (HSIs), gamma-glutamyl transferase (gamma GT), and lipid profile in adults with hyperlipidemia and nonalcoholic fatty liver disease (NAFLD). In vitro study on HepG2 cells explored potential molecular mechanisms. A retrospective study was conducted on 45 overweight/obese subjects (19 M) prescribed MHD with/without NS. Anthropometric data, biochemical parameters, HSIs, and gamma GT were collected at baseline and after 3 months. In vitro, cells were pretreated with single and mixed NS components and then with tumor necrosis factor alpha (TNF alpha) or fatty acids (FAs). Antioxidant and antiinflammatory activities were evaluated by fluorescence assays and quantitative polymerase chain reaction or enzyme-linked immunosorbent assay; antiapoptotic effects by Western blot. After 3 months, all subjects improved anthropometric and biochemical parameters but only the combined MHD and NS treatment significantly reduced insulin resistance, HSIs, low-density lipoprotein cholesterol, and gamma GT. In vitro, treatment with mixed NS components decreased TNF alpha-/FAs-induced reactive oxygen species. Combined treatment also modulated the inflammatory response by lowering interleukin-6 and interleukin-1 beta, increasing interleukin-10 and pro-caspase 8 expression. These findings suggest that NS, due to its antiinflammatory properties, represents a promising strategy for NAFLD management. C1 [Di Lorenzo, Mariana; Pipicelli, Luca; Aurino, Laura; Sozio, Concetta; Palmiero, Anna; Palmieri, Domenico; Lombardi, Marta; Guida, Bruna; Santillo, Mariarosaria; Lonardo, Maria Serena; La Rosa, Giuliana; Damiano, Simona] Univ Naples Federico II, Dept Clin Med & Surg, Physiol Unit, Naples, Italy. C3 University of Naples Federico II RP Lonardo, MS; La Rosa, G (通讯作者)，Univ Naples Federico II, Dept Clin Med & Surg, Physiol Unit, Naples, Italy. EM mariaserena.lonardo@unina.it; giuliana.larosa@unina.it RI Di+Lorenzo, Mariana/ABA-8353-2020; Sozio, Concetta/AHI-1980-2022; La Rosa, Giuliana/OGQ-0714-2025 OI Aurino, Laura/0000-0002-9060-2595; La Rosa, Giuliana/0000-0001-5704-4408; Pipicelli, Luca/0009-0001-9973-7031 FU Universita degli Studi di Napoli Federico II, as part of the Wiley - CRUI-CARE agreement FX Open access publishing facilitated by Universita degli Studi di Napoli Federico II, as part of the Wiley - CRUI-CARE agreement. 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Nutr. Food Res. PD NOV PY 2025 VL 69 IS 21 AR e70207 DI 10.1002/mnfr.70207 EA SEP 2025 PG 16 WC Food Science & Technology WE Science Citation Index Expanded (SCI-EXPANDED) SC Food Science & Technology GA 9LJ3T UT WOS:001564812800001 PM 40913543 OA Green Submitted, hybrid DA 2026-02-02 ER PT J AU Tsompanaki, E Thanapirom, K Papatheodoridi, M Parikh, P de Lima, YC Tsochatzis, EA AF Tsompanaki, Elena Thanapirom, Kessarin Papatheodoridi, Margarita Parikh, Pathik de Lima, Yasmin Chotai Tsochatzis, Emmanuel A. TI Systematic Review and Meta-analysis: The Role of Diet in the Development of Nonalcoholic Fatty Liver Disease SO CLINICAL GASTROENTEROLOGY AND HEPATOLOGY LA English DT Review DE Carbohydrates; Fatty Acids; Fructose; Metabolic Syndrome; Obesity; Protein ID MEDITERRANEAN DIET; COFFEE CONSUMPTION; METABOLIC SYNDROME; LIFE-STYLE; INSULIN SENSITIVITY; RISK-FACTORS; WEIGHT-LOSS; STEATOHEPATITIS; ASSOCIATION; SEVERITY AB BACKGROUND & AIMS: The association of nonalcoholic fatty liver disease (NAFLD) with dietary factors is well estab-lished but not thoroughly investigated. This systematic review and meta-analysis synthesizes available evidence regarding the effect of nutrition on the presence and severity of NAFLD. METHODS: A literature search was conducted identifying studies published between January 1985 and May 2021. We included studies with a dietary assessment and anthropometry based on validated tools, performed by a qualified dietitian or a trained health professional. We examined dif-ferences between patients with NAFLD and healthy controls as well as patients with NAFLD and nonalcoholic steatohepatitis (NASH). Risk of bias was assessed with the Risk Of Bias In Non-randomised Studies of Interventions (ROBINS-I) tool. RESULTS: There were 60 eligible studies with 100,621 patients. The risk of bias was moderate for the majority of studies (41/60; 68%). According to meta-analyses, total caloric intake was higher in patients with NAFLD compared with controls (mean difference, 78.08; 95% confidence interval, 41.03-115.13). Macronutrient (protein, fat, and carbohydrate) consumption as proportion of total caloric intake and daily intake of fiber, caffeine and vitamins E, A, and C did not signifi- cantly differ between patients with NAFLD and controls. Soft drink consumption had a trend towards association with the presence of NAFLD. However, the odds ratio was 4.4 and the confidence intervals very wide. Finally, there was no significant difference in any comparison between patients with NAFLD and NASH, although the number of patients was relatively small. All meta-analyses had significant heterogeneity. CONCLUSIONS: Overall, despite high heterogeneity among studies, this meta-analysis demonstrated that higher caloric intake is positively associated with NAFLD, whereas diet composition in macronutrients was not associated with the presence or severity of the disease. C1 [Tsompanaki, Elena; Thanapirom, Kessarin; Papatheodoridi, Margarita; Parikh, Pathik; de Lima, Yasmin Chotai; Tsochatzis, Emmanuel A.] Royal Free Hosp, UCL Inst Liver & Digest Hlth, London, England. [Thanapirom, Kessarin] Chulalongkorn Univ, Fac Med, Dept Med, Div Gastroenterol,Liver Fibrosis & Cirrhosis Res U, Bangkok, Thailand. [Thanapirom, Kessarin] King Chulalongkorn Mem Hosp, Thai Red Cross Soc, Bangkok, Thailand. [Tsochatzis, Emmanuel A.] Royal Free Hosp, Sheila Sherlock Liver Unit, London, England. [Tsochatzis, Emmanuel A.] UCL, London, England. C3 University of London; University College London; Royal Free London NHS Foundation Trust; UCL Medical School; Chulalongkorn University; Thai Red Cross Society; Chulalongkorn University; University of London; University College London; Royal Free London NHS Foundation Trust; UCL Medical School; University of London; University College London RP Tsochatzis, EA (通讯作者)，Royal Free Hosp, UCL Inst Liver & Digest Hlth, London, England.; Tsochatzis, EA (通讯作者)，Royal Free Hosp, Sheila Sherlock Liver Unit, London, England.; Tsochatzis, EA (通讯作者)，UCL, London, England. 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Gastroenterol. Hepatol. PD JUN PY 2023 VL 21 IS 6 BP 1462 EP + DI 10.1016/j.cgh.2021.11.026 EA MAY 2023 PG 37 WC Gastroenterology & Hepatology WE Science Citation Index Expanded (SCI-EXPANDED) SC Gastroenterology & Hepatology GA J8LI0 UT WOS:001012079100001 PM 34838723 OA Bronze DA 2026-02-02 ER PT J AU Gu, SX Qiao, YF Liu, SS Yang, SJ Cong, SB Wang, SL Yu, DS Wang, W Chai, XL AF Gu, Shuxiao Qiao, Yanfang Liu, Susu Yang, Shuangjie Cong, Shibo Wang, Sili Yu, Deshuai Wang, Wei Chai, Xinlou TI Frontiers and hotspots of adipose tissue and NAFLD: a bibliometric analysis from 2002 to 2022 SO FRONTIERS IN PHYSIOLOGY LA English DT Article DE non-alcoholic fatty liver disease; adipose tissue; bibliometrics; hotspots; CiteSpace; VOSviewer ID FATTY LIVER-DISEASE; CARDIOVASCULAR-DISEASE; DIABETES-MELLITUS; OBESITY; SEVERITY; STEATOHEPATITIS; INFLAMMATION; DECREASES; ACIDS; BETA AB Background: The annual incidence of non-alcoholic fatty liver disease (NAFLD) continues to rise steadily. In recent years, adipose tissue (AT) has gained recognition as a pivotal contributor to the pathogenesis of NAFLD. Employing bibliometric analysis, we examined literature concerning AT and NAFLD.Methods: Relevant literature on AT in NAFLD from 1980 to 2022 was extracted from the Web of Science Core Collection. These records were visualized using CiteSpace and VOSviewer regarding publications, countries/regions, institutions, authors, journals, references, and keywords.Results: Since 2002, a total of 3,330 papers have been included, exhibiting an annual surge in publications. Notably, the quality of publications is superior in the USA and Europe. Kenneth Cusi stands out as the author with the highest number of publications and H-index. Hepatology is the journal boasting the highest citation and H-index. The University of California System holds the highest centrality among institutions. References specifically delve into physiological processes associated with AT in NAFLD. Currently, lipid metabolism and inflammation constitute the principal research mechanisms in the AT-based regulation of NAFLD, with pertinent keywords including microRNA, T cell, hypoxia, sarcopenia, hepatokine, gut microbiota, and autophagy. The Mediterranean diet is among the most widely recommended dietary approaches for potential NAFLD treatment.Conclusion: This paper represents the inaugural bibliometric study on the effects of AT on NAFLD, offering valuable insights and directions for future research. C1 [Gu, Shuxiao; Qiao, Yanfang; Liu, Susu; Yang, Shuangjie; Cong, Shibo; Wang, Sili; Wang, Wei; Chai, Xinlou] Beijing Univ Chinese Med, Sch Tradit Chinese Med, Beijing, Peoples R China. [Yu, Deshuai] Beijing Univ Chinese Med, Dongzhimen Hosp, Beijing, Peoples R China. C3 Beijing University of Chinese Medicine; Beijing University of Chinese Medicine RP Wang, W; Chai, XL (通讯作者)，Beijing Univ Chinese Med, Sch Tradit Chinese Med, Beijing, Peoples R China. EM wangwei26960@126.com; mmxin3@126.com RI CONG, shibo/HCG-9761-2022 OI CONG, shibo/0000-0002-7214-3233 FU National Science and Technology Major Special Project based on big data research and development of new Chinese medicine drugs [2019ZX09201004-001-021] FX The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This work was supported by the National Science and Technology Major Special Project based on big data research and development of new Chinese medicine drugs (2019ZX09201004-001-021). 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Physiol. PD DEC 21 PY 2023 VL 14 AR 1278952 DI 10.3389/fphys.2023.1278952 PG 16 WC Physiology WE Science Citation Index Expanded (SCI-EXPANDED) SC Physiology GA DZ4I7 UT WOS:001135899300001 PM 38187139 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Soleimani, D Ranjbar, G Rezvani, R Goshayeshi, L Razmpour, F Nematy, M AF Soleimani, Davood Ranjbar, Golnaz Rezvani, Reza Goshayeshi, Ladan Razmpour, Farkhonde Nematy, Mohsen TI Dietary patterns in relation to hepatic fibrosis among patients with nonalcoholic fatty liver disease SO DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY LA English DT Article DE liver diseases; NAFLD; fibrosis; factor analysis; diet; dietary pattern ID TRANSIENT ELASTOGRAPHY; MEDITERRANEAN DIET; INSULIN-RESISTANCE; RISK; STEATOHEPATITIS; CONSUMPTION; OBESITY; REPRODUCIBILITY; HYPERTENSION; METAANALYSIS AB Background: Nonalcoholic fatty liver disease (NAFLD) is a multifactorial disorder that can progress to fibrosis. Several dietary patterns have been associated with histological features of NAFLD. However, little is known about the association between dietary patterns and hepatic fibrosis. Purpose: The current study aimed at identifying the relationship between major dietary patterns and hepatic fibrosis among patients with NAFLD. Subjects and methods: This cross-sectional study included 170 eligible subjects with NAFLD. Diet was evaluated using three 3-day dietary records during a 1-month period. Hepatic fibrosis was diagnosed using Fibroscan. Western, Iranian, and healthy dietary patterns were extracted using factor analysis. Results: After adjustment for other risk factors, adherence to a Western dietary pattern was associated with the higher odds of fibrosis (OR: 4.21; 95% CI: 1.63-8.31), whereas adherence to a healthy dietary pattern was associated with the lower odds of fibrosis (OR: 0.26; 95% CI: 0.10-0.49). Among main food groups, high intake of red meat, hydrogenated fats, and soft drinks was associated with the higher risk of fibrosis, whereas tea and coffee consumption had a protective role in hepatic fibrosis independent of other risk factors. Conclusion: The adherence to a healthy dietary pattern characterized by high intake of low-fat dairies, white meat, nuts, vegetables, fruits, and vegetable oils combined with coffee and tea consumption might be helpful in the nutritional strategies against hepatic fibrosis. C1 [Soleimani, Davood; Ranjbar, Golnaz; Rezvani, Reza; Razmpour, Farkhonde; Nematy, Mohsen] Mashhad Univ Med Sci, Fac Med, Dept Nutr, Mashhad, Iran. [Ranjbar, Golnaz] Univ Hertfordshire, Fac Life & Med Sci, Dept Biol & Environm Sci, Hatfield, Herts, England. [Rezvani, Reza] Univ Laval, Fac Sci Agr & Alimentat, Sch Nutr, Laval, PQ, Canada. [Goshayeshi, Ladan] Mashhad Univ Med Sci, Fac Med, Dept Gastroenterol & Hepatol, Mashhad, Iran. C3 Mashhad University of Medical Sciences; University of Hertfordshire; Laval University; Mashhad University of Medical Sciences RP Nematy, M (通讯作者)，Mashhad Med Sch, Dept Nutr, Azadi Sq, Mashhad 9177948564, Iran. EM NematyM@mums.ac.ir RI Rezvani, Reza/M-7642-2019; goshayeshi, ladan/AAQ-2715-2020; Razmpour, Farkhonde/AAU-6807-2021 OI Rezvani, Reza/0000-0003-3585-9854; Razmpour, Farkhonde/0000-0001-6258-4759; nematy, mohsen/0000-0003-3202-2709 FU Mashhad University of Medical Sciences, Mashhad, Iran FX We would like to appreciate the participants and assistants for their help in this study. All the financial support was provided by Mashhad University of Medical Sciences, Mashhad, Iran. 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Syndr. Obes. PY 2019 VL 12 BP 315 EP 324 DI 10.2147/DMSO.S198744 PG 10 WC Endocrinology & Metabolism WE Science Citation Index Expanded (SCI-EXPANDED) SC Endocrinology & Metabolism GA HP2FS UT WOS:000461484300001 PM 30881075 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Pirozzi, C Lama, A Simeoli, R Paciello, O Pagano, TB Mollica, MP Di Guida, F Russo, R Magliocca, S Canani, RB Raso, GM Calignano, A Meli, R AF Pirozzi, Claudio Lama, Adriano Simeoli, Raffaele Paciello, Orlando Pagano, Teresa Bruna Mollica, Maria Pina Di Guida, Francesca Russo, Roberto Magliocca, Salvatore Canani, Roberto Berni Raso, Giuseppina Mattace Calignano, Antonio Meli, Rosaria TI Hydroxytyrosol prevents metabolic impairment reducing hepatic inflammation and restoring duodenal integrity in a rat model of NAFLD SO JOURNAL OF NUTRITIONAL BIOCHEMISTRY LA English DT Article DE Nonalcoholic fatty liver disease; Olive oil polyphenols; Glucose tolerance; Liver inflammation; Insulin resistance; Duodenal permeability ID VIRGIN OLIVE OIL; HIGH-FAT DIET; ACTIVATED PROTEIN-KINASE; NECROSIS-FACTOR-ALPHA; PPAR-ALPHA; INSULIN-RESISTANCE; PHENOLIC-COMPOUNDS; LIVER-DISEASE; NONALCOHOLIC STEATOHEPATITIS; MEDITERRANEAN DIET AB The potential mechanisms of action of polyphenols in nonalcoholic fatty liver disease (NAFLD) are overlooked. Here, we evaluate the beneficial therapeutic effects of hydroxytyrosol (HT), the major metabolite of the oleuropein, in a nutritional model of insulin resistance (IR) and NAFLD by high-fat diet. Young male rats were divided into three groups receiving (1) standard diet (STD; 10.5% fat), (2) high-fat diet (HFD; 58.0% fat) and (3) HFD + HT (10 mg/kg/day by gavage). After 5 weeks, the oral glucose tolerance test was performed, and at 6th week, blood sample and tissues (liver and duodenum) were collected for following determinations. The HT-treated rats showed a marked reduction in serum AST, ALT and cholesterol and improved glucose tolerance and insulin sensitivity, reducing homeostasis model assessment index. HT significantly corrected the metabolic impairment induced by HFD, increasing hepatic peroxisome proliferator-activated receptor PPAR-a and its downstream-regulated gene fibroblast growth factor 21, the phosphorylation of acetyl-CoA carboxylase and the mRNA carnitine palmitoyltransferase la. HT also reduced liver inflammation and nitrosative/oxidative stress decreasing the nitrosylation of proteins, reactive oxygen species production and lipid peroxidation. Moreover, HT restored intestinal barrier integrity and functions (fluorescein isothiocyanate-dextran permeability and mRNA zona occludens ZO-1). Our data demonstrate the beneficial effect of HT in the prevention of early inflammatory events responsible for the onset of IR and steatosis, reducing hepatic inflammation and nitrosative/oxidative stress and restoring glucose homeostasis and intestinal barrier integrity. (C) 2016 Elsevier Inc. All rights reserved. C1 [Pirozzi, Claudio; Lama, Adriano; Simeoli, Raffaele; Di Guida, Francesca; Russo, Roberto; Magliocca, Salvatore; Raso, Giuseppina Mattace; Calignano, Antonio; Meli, Rosaria] Univ Naples Federico II, Dept Pharm, I-80131 Naples, Italy. [Paciello, Orlando; Pagano, Teresa Bruna] Univ Naples Federico II, Dept Vet Med & Anim Prod, I-80131 Naples, Italy. [Mollica, Maria Pina] Univ Naples Federico II, Dept Biol, I-80131 Naples, Italy. [Canani, Roberto Berni] Univ Naples Federico II, Dept Translat Med Sci, I-80131 Naples, Italy. [Canani, Roberto Berni] Univ Naples Federico II, European Lab Invest Food Induced Dis, I-80131 Naples, Italy. [Canani, Roberto Berni] Univ Naples Federico II, CEINGE Adv Biotechnol, I-80131 Naples, Italy. C3 University of Naples Federico II; University of Naples Federico II; University of Naples Federico II; University of Naples Federico II; University of Naples Federico II; University of Naples Federico II; CEINGE Biotecnologie Avanzate RP Meli, R (通讯作者)，Via D Montesano 49, I-80131 Naples, Italy. EM meli@unina.it RI ; Berni Canani, Roberto/AAC-4810-2022; Simeoli, Raffaele/J-1101-2018; russo, roberto/A-3193-2012; Calignano, Antonio/K-2542-2018; Lama, Adriano/AAC-1964-2020; Pirozzi, Claudio/S-2760-2016 OI Mollica, Maria Pina/0000-0003-2726-7779; Meli, Rosaria/0000-0002-6246-6813; Berni Canani, Roberto/0000-0002-5169-9574; Simeoli, Raffaele/0000-0002-3989-7703; Pirozzi, Claudio/0000-0002-3409-5744; Mattace Raso, Giuseppina/0000-0002-5254-139X FU Italian Ministry of University and Research PRIN [2010JCWWKM-005] FX Preliminary data of this study were supported by a grant from Italian Ministry of University and Research PRIN 2010-2011 - prot. 2010JCWWKM-005. 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Nutr. Biochem. PD APR PY 2016 VL 30 BP 108 EP 115 DI 10.1016/j.jnutbio.2015.12.004 PG 8 WC Biochemistry & Molecular Biology; Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Biochemistry & Molecular Biology; Nutrition & Dietetics GA DJ6TY UT WOS:000374347300012 PM 27012627 DA 2026-02-02 ER PT J AU Meir, AY Keller, M Müller, L Bernhart, SH Tsaban, G Zelicha, H Rinott, E Kaplan, A Gepner, Y Shelef, I Schwarzfuchs, D Ceglarek, U Stadler, P Blüher, M Stumvoll, M Kovacs, P Shai, I AF Yaskolka Meir, Anat Keller, Maria Mueller, Luise Bernhart, Stephan H. Tsaban, Gal Zelicha, Hila Rinott, Ehud Kaplan, Alon Gepner, Yftach Shelef, Ilan Schwarzfuchs, Dan Ceglarek, Uta Stadler, Peter Blueher, Matthias Stumvoll, Michael Kovacs, Peter Shai, Iris TI Effects of lifestyle interventions on epigenetic signatures of liver fat: Central randomized controlled trial SO LIVER INTERNATIONAL LA English DT Article DE Diet; DNA‐ methylation; genetic variation; nonalcoholic fatty liver disease; physical activity ID DNA METHYLATION; GENE-EXPRESSION; POLYPHENOLS; DISEASE; PNPLA3; BLOOD; NAFLD; DIET AB Background and Aims In the CENTRAL trial context, we found diverse liver fat dynamics in response to different dietary interventions. Epigenetic mechanisms may contribute to the intraindividual variation. Moreover, genetic factors are involved in developing nonalcoholic fatty-liver disease (NAFLD), a disease reflected by an increase in intrahepatic fat (IHF). In this exploratory analysis, we primarily aimed to examine the effect of lifestyle interventions on DNA-methylation of NAFLD related genes associated with IHF. Methods For 120 participants from the CENTRAL trial, an 18-month regimen of either low-fat (LF) or Mediterranean-low carbohydrate (MED/LC) diets, with or without physical activity (PA+/PA-), was instructed. Magnetic resonance imaging was used to measure IHF%, which was analysed for association with CpG specific DNA-methylation levels of 41 selected candidate genes. Single-nucleotide polymorphisms known to be associated with NAFLD within the studied genes were genotyped by TaqMan assays. Results At baseline, participants (92% men; body mass index = 30.2 kg/m(2)) had mean IHF of 10.7% (59% NAFLD). Baseline-IHF% was inversely correlated with DNA-methylation at individual CpGs within AC074286.1, CRACR2A, A2MP1, FARP1 (P < .05 for all multivariate models). FARP1 rs9584805 showed association with IHF, with the prevalence of NAFLD and baseline methylation level of the CpG site (cg00071727) associated with IHF%. Following 18-month lifestyle intervention, differential DNA-methylation patterns were observed between diets at cg14335324 annotated to A2MP1 (P = .04, LF vs. MED/LC), and differential DNA-methylation between PA groups within AC074286.1, CRACR2A, and FARP1 CpGs (P < .05 for all, PA-vs. PA+). Conclusions This study suggests epigenetic markers for IHF and potential epigenetic remodeling after long-term lifestyle interventions. C1 [Yaskolka Meir, Anat; Tsaban, Gal; Zelicha, Hila; Rinott, Ehud; Kaplan, Alon; Shai, Iris] Ben Gurion Univ Negev, Fac Hlth Sci, Beer Sheva, Israel. [Keller, Maria; Blueher, Matthias; Stumvoll, Michael] Univ Leipzig, Helmholtz Ctr Munich, Helmholtz Inst Metab Obes & Vasc Res HI MAG, Leipzig, Germany. [Keller, Maria; Blueher, Matthias; Stumvoll, Michael] Univ Hosp Leipzig, Leipzig, Germany. [Keller, Maria; Mueller, Luise; Blueher, Matthias; Stumvoll, Michael; Kovacs, Peter] Univ Leipzig, Med Ctr, Med Dept Endocrinol Nephrol Rheumatol 3, Liebigstr 19-21, D-04103 Leipzig, Germany. [Bernhart, Stephan H.] Univ Leipzig, Interdisciplinary Ctr Bioinformat, Leipzig, Germany. [Bernhart, Stephan H.; Stadler, Peter] Univ Leipzig, Dept Comp Sci, Bioinformat Grp, Leipzig, Germany. [Bernhart, Stephan H.] Univ Leipzig, LIFE Res Ctr Civilizat Dis, Transcriptome Bioinformat, Leipzig, Germany. [Gepner, Yftach] Tel Aviv Univ, Dept Epidemiol & Prevent Med, Sch Publ Hlth, Sackler Fac Med,Sylvan Adams Sports Inst, Tel Aviv, Israel. [Shelef, Ilan; Schwarzfuchs, Dan] Soroka Univ Med Ctr, Beer Sheva, Israel. [Ceglarek, Uta] Univ Leipzig, Med Ctr, Inst Lab Med, Leipzig, Germany. [Stadler, Peter] Univ Leipzig, Competence Ctr Scalable Data Serv & Solut Dresden, German Ctr Integrat Biodivers Res iDiv, Leipzig Res Ctr Civilizat Dis, Leipzig, Germany. [Stadler, Peter] Max Planck Inst Math Sci, Leipzig, Germany. [Stadler, Peter] Fraunhofer Inst Cell Therapy & Immunol, Leipzig, Germany. [Stadler, Peter] Univ Vienna, Dept Theoret Chem, Vienna, Austria. [Stadler, Peter] Univ Copenhagen, Ctr RNA Technol & Hlth, Frederiksberg, Denmark. [Stadler, Peter] Santa Fe Inst, Santa Fe, NM 87501 USA. [Stumvoll, Michael] Deutsch Zentrum Diabet Forsch, Neuherberg, Germany. [Shai, Iris] Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA. C3 Ben-Gurion University of the Negev; Helmholtz Association; Helmholtz-Center Munich - German Research Center for Environmental Health; Leipzig University; Leipzig University; Leipzig University; Leipzig University; Leipzig University; Leipzig University; Tel Aviv University; Sackler Faculty of Medicine; Ben-Gurion University of the Negev; Soroka Medical Center; Leipzig University; German Research Foundation (DFG); German Centre for Integrative Biodiversity Research (iDiv); Leipzig University; Max Planck Society; Fraunhofer Gesellschaft; Fraunhofer Germany; Fraunhofer Cell Therapy & Immunology; University of Vienna; University of Copenhagen; The Santa Fe Institute; Harvard University; Harvard T.H. Chan School of Public Health RP Kovacs, P (通讯作者)，Univ Leipzig, Med Ctr, Med Dept Endocrinol Nephrol Rheumatol 3, Liebigstr 19-21, D-04103 Leipzig, Germany.; Shai, I (通讯作者)，Ben Gurion Univ Negev, Dept Publ Hlth, Fac Hlth Sci, POB 653, IL-84105 Beer Sheva, Israel. EM peter.kovacs@medizin.uni-leipzig.de; irish@bgu.ac.il RI Shai, Iris/HJO-8533-2023; Stumvoll, Michael/ABE-1121-2021; Stadler, Peter F/L-7857-2015; Kovacs, Peter/KCK-1454-2024; Ceglarek, Uta/GOE-5561-2022; Meir, Anat/AAK-7469-2021; Keller, Maria/AAD-4877-2020; Rinott, Ehud/KRO-7063-2024 OI Shai, Iris/0000-0001-9050-4605; Stumvoll, Michael/0000-0001-6225-8240; Zelicha, Hila/0000-0001-6989-2332; , Stephan/0000-0002-5928-9449; Stadler, Peter F/0000-0002-5016-5191; Kovacs, Peter/0000-0002-0290-5423; FU Free State of Saxony; Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) [209933838-SFB 1052]; German Diabetes Association; Deutsches Zentrum fur Diabetesforschung; Israel Science Foundation (ISF), Israel Ministry of Science and Technology [3-13604]; Dr Robert C. and Veronica Atkins Research Foundation FX This work has been supported by the Free State of Saxony and grants from the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation-Projekt nummer 209933838-SFB 1052; B01, B03, B11, Z04), from the German Diabetes Association and Deutsches Zentrum fur Diabetesforschung. The CENTRAL RCT was supported by the Israel Science Foundation (ISF), Israel Ministry of Science and Technology (grant #3-13604), and the Dr Robert C. and Veronica Atkins Research Foundation. The funders were not involved in the study. 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PD SEP PY 2021 VL 41 IS 9 BP 2101 EP 2111 DI 10.1111/liv.14916 EA MAY 2021 PG 11 WC Gastroenterology & Hepatology WE Science Citation Index Expanded (SCI-EXPANDED) SC Gastroenterology & Hepatology GA UA4XT UT WOS:000655743300001 PM 33938135 DA 2026-02-02 ER PT J AU Haghighatdoost, F Salehi-Abargouei, A Surkan, PJ Azadbakht, L AF Haghighatdoost, Fahimeh Salehi-Abargouei, Amin Surkan, Pamela J. Azadbakht, Leila TI The effects of low carbohydrate diets on liver function tests in nonalcoholic fatty liver disease: A systematic review and meta-analysis of clinical trials SO JOURNAL OF RESEARCH IN MEDICAL SCIENCES LA English DT Review DE Alanine transaminase; aspartate aminotransferases; glutamyl aminotransferase; liver fat content; low carbohydrate diet; nonalcoholic fatty liver ID ALANINE AMINOTRANSFERASE LEVELS; INSULIN-RESISTANCE; MEDITERRANEAN DIET; HEPATIC STEATOSIS; RANDOMIZED-TRIAL; OBESE CHILDREN; UNITED-STATES; STEATOHEPATITIS; RESTRICTION; SENSITIVITY AB Background: Although several observational and experimental studies have examined the effects of low carbohydrate diets (LCDs) on nonalcoholic fatty liver disease (NAFLD), there are considerable inconsistencies among studies. We summarized the effect of LCDs on liver function tests, including intrahepatic lipid content (IHLC), alanine transaminase (ALT), aspartate aminotransferases (AST), and gamma-glutamyl transferase (GGT) in patients with NAFLD. Materials and Methods: PubMed, ISI Web of Science, Scopus, and Google Scholar databases were searched for relevant publications until July 2014, resulting in ten relevant papers that were included in meta-analysis. Related articles were found by searching Medical Subject Heading terms of "NAFLD" in combination with " low carbohydrate." For this meta-analysis, we used mean differences and standard errors of liver function biomarkers. Summary effect and corresponding confidence interval (CI) were estimated using random effect models. Heterogeneity between studies was assessed using Cochran's Q-and I-squared tests. Results: Our search led to ten eligible papers that evaluated serum ALT levels (n = 238), nine reported serum AST levels (n = 216), five reported serum GGT concentrations (n = 91), and four assessed IHLC (n = 50). LCD decreased IHLC by -11.53% (95% CI: -18.10, -4.96; I-2 = 83.2%). However, the effect of LCD on liver enzymes was not significant. Mean differences for the effects of LCDs on ALT, AST, and GGT were -4.35 IU/L (95% CI: -12.91, 4.20; I-2 = 87.9%),-1.44 IU/L (95% CI: -4.98, 2.10; I-2 = 61.4%), and -7.85 IU/L (95% CI: -29.65, 13.96; I-2 = 99.4%), respectively. Conclusion: LCD consumption in subjects with NAFLD led to a significant reduction in IHLC, but did not significantly affect the concentration of liver enzymes. C1 [Haghighatdoost, Fahimeh; Azadbakht, Leila] Isfahan Univ Med Sci, Food Secur Res Ctr, Esfahan, Iran. [Haghighatdoost, Fahimeh; Azadbakht, Leila] Isfahan Univ Med Sci, Sch Nutr & Food Sci, Dept Community Nutr, Esfahan, Iran. [Haghighatdoost, Fahimeh] Isfahan Univ Med Sci, Students Res Comm, Dept Community Nutr, Esfahan, Iran. [Salehi-Abargouei, Amin] Shahid Sadoughi Univ Med Sci, Nutr & Food Secur Res Ctr, Yazd, Iran. [Salehi-Abargouei, Amin] Shahid Sadoughi Univ Med Sci, Fac Hlth, Dept Nutr, Yazd, Iran. [Azadbakht, Leila] Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Community Nutr, Tehran, Iran. [Azadbakht, Leila] Univ Tehran Med Sci, Diabet Res Ctr, Endocrinol & Metab Clin Sci Inst, Tehran, Iran. [Surkan, Pamela J.] Johns Hopkins Sch Publ Hlth, Dept Int Hlth, Baltimore, MD USA. C3 Isfahan University of Medical Sciences; Isfahan University of Medical Sciences; Isfahan University of Medical Sciences; Shahid Sadoughi University of Medical Sciences; Shahid Sadoughi University of Medical Sciences; Tehran University of Medical Sciences; Tehran University of Medical Sciences; Johns Hopkins University; Johns Hopkins Bloomberg School of Public Health RP Azadbakht, L (通讯作者)，Isfahan Univ Med Sci, Sch Nutr & Food Sci, Dept Community Nutr, Esfahan, Iran. EM azadbakht@hlth.mui.ac.ir RI ; Haghighatdoost, Fahimeh/AGH-2969-2022; Salehi-Abargouei, Amin/C-9039-2011; Azadbakht, Leila/N-2801-2018 OI Surkan, Pamela/0000-0002-0334-5931; Salehi-Abargouei, Amin/0000-0002-7580-6717; Azadbakht, Leila/0000-0002-5955-6818 FU School of Nutrition and Food Science, Isfahan University of Medical Sciences FX The School of Nutrition and Food Science, Isfahan University of Medical Sciences. 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Res. Med. Sci. PY 2016 VL 21 PG 8 WC Medicine, General & Internal WE Science Citation Index Expanded (SCI-EXPANDED) SC General & Internal Medicine GA DZ4GU UT WOS:000385817500003 PM 27904598 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Aerts, M Rosseel, Z De Waele, E AF Aerts, Maridi Rosseel, Zenzi De Waele, Elisabeth TI The Evolution in Non-Alcoholic Fatty Liver Disease Patients' Profile and the Associated Sustainable Challenges: A Multidisciplinary Perspective SO NUTRIENTS LA English DT Review DE cirrhosis; nutrition; sustainability; waste; NAFLD ID ULTRA-PROCESSED FOODS; SHORT-SLEEP DURATION; MEDICATION ADHERENCE; MEDITERRANEAN DIET; SELF-MANAGEMENT; CIRRHOSIS; QUALITY; EXERCISE; NAFLD; CARE AB The prevalence and incidence of NAFLD is rising due to the obesity pandemic, caused by the widespread availability of ultra-processed foods and the decrease of physical activity. Factors such as socioeconomic status (SES), ethnicity and geographical location are associated with NAFLD, with lower SES correlating with higher incidence, particularly in regions like America or Europe. Beside the quality of food, the quantity also plays a crucial role. The World Health Organization (WHO) recommends a Mediterranean diet with a balanced energy intake. Since no hard medical treatment is available for NAFLD, lifestyle adjustments are key. Patient empowerment by providing relevant information and co-ownership of the therapy will increase the implementation rate and enhance the quality of medical follow-up and medication adherence, as studies report a good adherence to medication among patients who are well-aware of the severity of their disease. Regarding sustainability, patients with NAFLD have a high load of ambulatory follow-up, which, since the COVID-19 pandemic, can be partially provided by teleconsulting. Both patients' lifestyle modifications and healthcare practitioners' therapeutical strategy can decrease the carbon footprint. C1 [Aerts, Maridi] Univ Ziekenhuis Brussel UZB, Dept Gastroenterol & Hepatol, B-1090 Brussels, Belgium. [Rosseel, Zenzi] Univ Ziekenhuis Brussel UZB, Dept Pharm, B-1090 Brussels, Belgium. [Rosseel, Zenzi; De Waele, Elisabeth] Univ Ziekenhuis Brussel UZB, Dept Clin Nutr, B-1090 Brussels, Belgium. [De Waele, Elisabeth] Vrije Univ Brussel VUB, Fac Med & Pharm, B-1090 Brussels, Belgium. C3 University Hospital Brussels; University Hospital Brussels; University Hospital Brussels; Vrije Universiteit Brussel RP Rosseel, Z (通讯作者)，Univ Ziekenhuis Brussel UZB, Dept Pharm, B-1090 Brussels, Belgium.; Rosseel, Z (通讯作者)，Univ Ziekenhuis Brussel UZB, Dept Clin Nutr, B-1090 Brussels, Belgium. 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TI The Effects of Extra Virgin Olive Oil on Alanine Aminotransferase, Aspartate Aminotransferase, and Ultrasonographic Indices of Hepatic Steatosis in Nonalcoholic Fatty Liver Disease Patients Undergoing Low Calorie Diet SO CANADIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY LA English DT Article ID MEDITERRANEAN DIET; WEIGHT-LOSS; NAFLD; ACIDS; PREVALENCE AB Background. Coronary artery disease is the most common cause of death in the patients with nonalcoholic fatty liver disease (NAFLD). Studies have shown that there is a strong relation between the increase in the aminotransferase levels and fat accumulation in the liver with cardiovascular complications, independent of all aspects of the metabolic syndrome. This study aimed to examine the effect of virgin olive oil on alanine aminotransferase (ALT) and aspartate aminotransferase (AST) and the severity of steatosis in the NAFLD patients undergoing a weight-loss diet. Methods. This clinical trial was carried out on 50 patients with nonalcoholic fatty liver (mean age of 45.91 +/- 9.61 years, mean BMI of 29.7 +/- 0.58Kg/m(2)) and the subjects were randomly assigned to the olive oil group (receiving the equivalent of 20% of their total daily energy requirement from olive oil) or the control group (with normal consumption of oil) for 12 weeks. All the patients received a hypocaloric diet during the study. At the beginning and the end of the study, the serum levels of ALT and AST and liver steatosis were measured. Findings. A significant decrease in the level of ALT enzymes was observed in the control group at the end of the study (p = 0.004). In the olive oil group, both enzymes decreased compared to baselinemeasurements (p < 0.01). Therewere significant differences in the ALT andAST levels between the two groups (p < 0.02). The severity of liver steatosis did not change significantly during the study. Conclusion. The consumption of a low calorie diet enriched with olive oil, along with slight weight reduction, reinforces the desired effects of weight loss in improving the levels of the hepatic enzymes. C1 [Shidfar, Farzad; Bahrololumi, Samaneh Sadat] Iran Univ Med Sci, Sch Publ Hlth, Dept Nutr, Tehran, Iran. [Doaei, Saeid] North Khorasan Univ Med Sci, Nat Prod & Med Plants Res Ctr, Bojnurd, Iran. [Doaei, Saeid] North Khorasan Univ Med Sci, Sch Hlth, Dept Publ Hlth, Bojnurd, Iran. [Mohammadzadeh, Assieh] Ahvaz Jundishapur Univ Med Sci, Dept Nutr Sci, Student Res Comm, Ahvaz, Iran. [Gholamalizadeh, Maryam] Shahid Beheshti Univ Med Sci, Canc Res Ctr, Student Res Comm, Tehran, Iran. [Mohammadimanesh, Ali] Hamadan Univ Med Sci, Student Counseling Ctr, Hamadan, Iran. C3 Iran University of Medical Sciences; North Khorasan University of Medical Sciences; North Khorasan University of Medical Sciences; Ahvaz Jundishapur University of Medical Sciences (AJUMS); Shahid Beheshti University Medical Sciences; Hamadan University of Medical Sciences RP Bahrololumi, SS (通讯作者)，Iran Univ Med Sci, Sch Publ Hlth, Dept Nutr, Tehran, Iran. EM sama.ss74@yahoo.com RI ; Doaei, Saeid/X-6425-2018; Doaei, Saeid/X-6425-2018; shidfar, Farzad/H-6651-2018 OI Gholamalizadeh, Maryam/0000-0001-8289-8819; Doaei, Saeid/0000-0002-1337-4963; Doaei, Saeid/0000-0002-2532-7478; shidfar, Farzad/0000-0002-6531-9253 FU Khoramshahr Oil Company FX This paper is derived from the M.S. thesis of Samaneh Sadat Bahrololumi, submitted to Tehran University of Medical Sciences, Tehran, Iran (Code: 15369). This paper was supported by the Khoramshahr Oil Company. The authors would like to thank Javad Salimi, head of the oil factory of Ganjeh, Roudbar, and Aboozar Falahzadeh, head of the oil factory laboratory. 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J. Gastroenterol. Hepatol. PY 2018 VL 2018 AR 1053710 DI 10.1155/2018/1053710 PG 7 WC Gastroenterology & Hepatology WE Science Citation Index Expanded (SCI-EXPANDED) SC Gastroenterology & Hepatology GA GE5MT UT WOS:000431267300001 PM 29850450 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Vachliotis, ID Vasiloglou, MF Kapama, A Matsagkos, D Goulas, A Papaioannidou, P Polyzos, SA AF Vachliotis, Ilias D. Vasiloglou, Maria F. Kapama, Aikaterini Matsagkos, Dimitrios Goulas, Antonis Papaioannidou, Paraskevi Polyzos, Stergios A. TI Association between hepatic steatosis and fibrosis indices and dietary habits, physical activity, and quality of life SO ARAB JOURNAL OF GASTROENTEROLOGY LA English DT Article DE Nonalcoholic fatty liver disease; Fibrosis; Quality of life; Diet; Mediterranean; Exercise ID FATTY LIVER-DISEASE; MEDITERRANEAN DIET; NONALCOHOLIC STEATOHEPATITIS; VALIDATION; ADHERENCE; NAFLD; SCORE AB Background and study aims: This cross-sectional study aimed to evaluate the association between hepatic steatosis and fibrosis indices and adherence to the Mediterranean diet (MD), physical activity (PA), and quality of life (QoL) in individuals unaware of the status of their liver. Patients and methods: Participants were asked to complete three questionnaires validated in Greek, namely: (1) the Chronic Liver Disease Questionnaire (CLDQ) for QoL assessment; (2) the semi -quantitative Food Frequency Questionnaire (FFQ), from which the MedDietScore was calculated; and (3) the International Physical Activity Questionnaire (IPAQ) for PA evaluation. Hepatic steatosis was eval-uated using the Fatty Liver Index (FLI), Hepatic Steatosis Index (HSI), and Lipid Accumulation Product (LAP). Hepatic fibrosis was evaluated using the NAFLD Fibrosis Score (NFS), Fibrosis-4 (FIB-4), and AST -to-platelet ratio index (APRI). Results: This study recruited 200 participants (90% men) aged 36 +/- 6 years. Hepatic steatosis indices were not associated with MedDietScore and QoL. In terms of PA, univariable analysis showed that higher val-ues of hepatic steatosis indices were associated with less intense activity. This association remained sig-nificant only for HSI during multivariable analysis (moderate activity vs. low activity: beta:-2.0, 95% confidence interval (CI):-3.5,-0.37, p = 0.016; and high activity vs. low activity: beta:-3.3, 95% CI:-5.03,-1.60, p < 0.001), after controlling for age, waist circumference, and the presence of metabolic syndrome. When using hepatic fibrosis indices, none of the participants had high probability of advanced hepatic fibrosis or cirrhosis (F3-F4). Consequently, we were unable to extensively evaluate the associa-tion between hepatic fibrosis indices and lifestyle characteristics or QoL. Conclusion: We showed that HSI, but not other steatosis indices, remained robustly associated with PA after adjusting for potential confounders in a population unaware of the presence of fatty liver. (c) 2022 Pan-Arab Association of Gastroenterology. Published by Elsevier B.V. All rights reserved. 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Gastroenterol. PD NOV PY 2022 VL 23 IS 4 BP 277 EP 287 DI 10.1016/j.ajg.2022.05.006 PG 11 WC Gastroenterology & Hepatology WE Science Citation Index Expanded (SCI-EXPANDED) SC Gastroenterology & Hepatology GA 7C4XP UT WOS:000899818100011 PM 35927197 DA 2026-02-02 ER PT J AU Tutunchi, H Saghafi-Asl, M Asghari-Jafarabadi, M Ostadrahimi, A AF Tutunchi, Helda Saghafi-Asl, Maryam Asghari-Jafarabadi, Mohammad Ostadrahimi, Alireza TI Association between Dietary Patterns and Non-alcoholic Fatty Liver Disease: Results from a Case-Control Study SO ARCHIVES OF IRANIAN MEDICINE LA English DT Article DE Adult population; Dietary patterns; Factor analysis; Non-alcoholic fatty liver (NAFLD) ID MEDITERRANEAN DIET; METABOLIC SYNDROME; PREVALENCE; PREVENTION; OBESITY; RISK AB Background: This study aimed to investigate the association between dietary patterns and non-alcoholic fatty liver disease (NAFLD) among Iranian adults. Methods: This case-control study was conducted on 210 subjects. NAFLD diagnosis was made by ultrasound examination. Anthropometric measures, physical activity, fasting serum levels of glucose, alanine aminotransferase (ALT), aspartate aminotransferase, and lipid profile were assessed. A three-day food diary was used to assess dietary intakes of the subjects. Dietary patterns were determined using factor analysis. To determine the relationship between dietary patterns and NAFLD, multivariable-adjusted odds ratio (OR) obtained from the logistic regression analysis was used. Results: Two dietary patterns were extracted as follows: vegetables, legumes, fruits, and low-fat dairy products (VLFD); and sweet, hydrogenated fat, red and processed meat, and soft drink (SHMS) dietary patterns. By taking all possible confounders into account, the VLFD dietary pattern was found to be significantly related to lower odds of NAFLD, while the SHMS dietary pattern was independently related to higher odds of NAFLD (P < 0.05). Among major food groups, high consumption of processed meat, hydrogenated fats, sweets and desserts, and soft drinks was positively related to NAFLD (P < 0.05), whereas vegetable consumption exhibited a protective role against NAFLD (P = 0.01). Conclusion: The VLFD dietary pattern was associated with reduced likelihood of having NAFLD, while the SHMS dietary pattern was associated with higher likelihood. Therefore, the VLFD dietary pattern might be useful in the nutritional strategies for NAFLD patients. Further studies with larger sample sizes and prospective design are warranted. C1 [Tutunchi, Helda] Tabriz Univ Med Sci, Sch Nutr & Food Sci, Dept Clin Nutr, Student Res Comm,Nutr Res Ctr, Tabriz, Iran. [Saghafi-Asl, Maryam; Ostadrahimi, Alireza] Tabriz Univ Med Sci, Sch Nutr & Food Sci, Dept Clin Nutr, Nutr Res Ctr, Tabriz 5166614711, Iran. [Asghari-Jafarabadi, Mohammad] Tabriz Univ Med Sci, Rd Traff Injury Res Ctr, Tabriz, Iran. C3 Tabriz University of Medical Science; Tabriz University of Medical Science; Tabriz University of Medical Science RP Ostadrahimi, A (通讯作者)，Tabriz Univ Med Sci, Sch Nutr & Food Sci, Dept Clin Nutr, Nutr Res Ctr, Tabriz 5166614711, Iran. EM ostadrahimi@tbzmed.ac.ir RI ostaahimi, alireza/G-1569-2017; Asghari Jafarabadi, Mohammmad/A-7478-2017; Tutunchi, Helda/AAC-1573-2022 OI ostaahimi, alireza/0000-0002-1058-1481; Asghari Jafarabadi, Mohammmad/0000-0003-3284-9749; Tutunchi, Helda/0000-0002-4795-1757 FU Nutrition Research Center of Tabriz University of Medical Sciences; Iran National Science Foundation (INSF) FX The study was financially supported by the Nutrition Research Center of Tabriz University of Medical Sciences, and Iran National Science Foundation (INSF). 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Iran. Med. PD JAN PY 2021 VL 24 IS 1 BP 35 EP 42 DI 10.34172/aim.2021.06 PG 8 WC Medicine, General & Internal WE Science Citation Index Expanded (SCI-EXPANDED) SC General & Internal Medicine GA QG2VV UT WOS:000617449000006 PM 33588566 OA hybrid DA 2026-02-02 ER PT J AU Abbate, M Mascaró, CM Montemayor, S Barbería-Latasa, M Casares, M Gómez, C Angullo-Martinez, E Tejada, S Abete, I Zulet, MA Sureda, A Martinez, JA Tur, JA AF Abbate, Manuela Mascaro, Catalina M. Montemayor, Sofia Barberia-Latasa, Maria Casares, Miguel Gomez, Cristina Angullo-Martinez, Escarlata Tejada, Silvia Abete, Itziar Angeles Zulet, Maria Sureda, Antoni Alfredo Martinez, J. Tur, Josep A. TI Energy Expenditure Improved Risk Factors Associated with Renal Function Loss in NAFLD and MetS Patients SO NUTRIENTS LA English DT Article DE glomerular hyperfiltration; albumin-to-creatinine ratio; non-alcoholic fatty liver disease; caloric restriction; increased energy expenditure ID FATTY LIVER-DISEASE; PHYSICAL-ACTIVITY QUESTIONNAIRE; GLOMERULAR HYPERFILTRATION; INSULIN-RESISTANCE; CARDIOVASCULAR-DISEASE; SURFACE-AREA; MICROALBUMINURIA; REDUCTION; GLUCOSE; OBESITY AB To assess the efficacy of three lifestyle interventions on the reduction of liver fat content and metabolic syndrome (MetS), and whether such reductions would influence renal outcomes, we conducted a randomized controlled trial on 128 participants with MetS and non-alcoholic fatty liver disease (NAFLD), as well as available data on estimated glomerular filtration rate (eGFR) and urinary albumin-to-creatine ratio (UACR). Patients were randomized in 1:1:1 ratio to either Conventional Diet, Mediterranean diet (MD)-high meal frequency, and MD-physical activity groups. Each intervention aimed at reducing caloric intake by 25%-30% of baseline intake and increase energy expenditure by 400 kcal/70 kg. Patients attended regular visits and were followed-up for 6 months. Increased albuminuria was present in 13.3% of patients, while 32.8% showed hyperfiltration. UACR reduction was associated with higher levels of UACR at baseline but not with changes in liver fat. eGFR decreased in patients presenting hyperfiltration at baseline and was associated with reduction in liver fat and insulin resistance, as well as with increase in energy expenditure (R-2 = 0.248, p = 0.006). No significant differences were observed between the three treatment groups. In patients with NAFLD and MetS, energy expenditure significantly reduced hepatic fat accumulation and insulin resistance, which reduced glomerular hyperfiltration. Increased albuminuria was reduced, but it was not associated with reduced liver fat. C1 [Abbate, Manuela; Mascaro, Catalina M.; Montemayor, Sofia; Angullo-Martinez, Escarlata; Tejada, Silvia; Sureda, Antoni; Tur, Josep A.] Univ Balearic Isl, Univ Res Inst Hlth Sci Iun, Res Grp Community Nutr & Oxidat Stress, Palma De Mallorca 07122, Spain. [Abbate, Manuela; Mascaro, Catalina M.; Montemayor, Sofia; Angullo-Martinez, Escarlata; Tejada, Silvia; Sureda, Antoni; Tur, Josep A.] Hlth Res Inst Balearic Isl IdISBa, Palma De Mallorca 07120, Spain. [Barberia-Latasa, Maria] Univ Navarra, Dept Prevent Med & Publ Hlth, Pamplona 31008, Spain. [Casares, Miguel] Red Asistencial Juaneda, Radiodiag Serv, Palma De Mallorca 07011, Spain. [Gomez, Cristina] Univ Hosp Son Espases, Clin Anal Serv, Palma De Mallorca 07120, Spain. [Angullo-Martinez, Escarlata] Escola Graduada Primary Hlth Care Ctr, Palma De Mallorca 07002, Spain. [Tejada, Silvia; Abete, Itziar; Angeles Zulet, Maria; Sureda, Antoni; Alfredo Martinez, J.; Tur, Josep A.] Inst Salud Carlos III ISCIII, CIBER Physiopathol Obes & Nutr CIBEROBN, Madrid 28029, Spain. [Abete, Itziar; Angeles Zulet, Maria; Alfredo Martinez, J.] Univ Navarra, Ctr Nutr Res, Dept Nutr Food Sci & Physiol, Pamplona 31008, Spain. [Alfredo Martinez, J.] CEI UAM CSIC, IMDEA Food, Cardiomet Precis Nutr Program, Madrid 28049, Spain. [Tur, Josep A.] Univ Balearic Isl, Res Grp Community Nutr & Oxidat Stress, IDISBA, Guillem Colom Bldg, Palma De Mallorca 07122, Spain. [Tur, Josep A.] CIBEROBN, Guillem Colom Bldg, Palma De Mallorca 07122, Spain. C3 Universitat de les Illes Balears; Institut Investigacio Sanitaria Illes Balears (IdISBa); University of Navarra; Hospital Universitari Son Espases; CIBER - Centro de Investigacion Biomedica en Red; CIBEROBN; University of Navarra; IMDEA Food Institute; Consejo Superior de Investigaciones Cientificas (CSIC); Universitat de les Illes Balears; Institut Investigacio Sanitaria Illes Balears (IdISBa); CIBER - Centro de Investigacion Biomedica en Red; CIBEROBN RP Tur, JA (通讯作者)，Univ Balearic Isl, Univ Res Inst Hlth Sci Iun, Res Grp Community Nutr & Oxidat Stress, Palma De Mallorca 07122, Spain.; Tur, JA (通讯作者)，Hlth Res Inst Balearic Isl IdISBa, Palma De Mallorca 07120, Spain.; Tur, JA (通讯作者)，Inst Salud Carlos III ISCIII, CIBER Physiopathol Obes & Nutr CIBEROBN, Madrid 28029, Spain.; Tur, JA (通讯作者)，Univ Balearic Isl, Res Grp Community Nutr & Oxidat Stress, IDISBA, Guillem Colom Bldg, Palma De Mallorca 07122, Spain.; Tur, JA (通讯作者)，CIBEROBN, Guillem Colom Bldg, Palma De Mallorca 07122, Spain. EM manuela.abbate@uib.es; c.mascaro@uib.es; sofiamf16@gmail.com; mbarberia.3@alumni.unay.es; casaresmiguel@gmail.com; cristina.gomez@ssib.es; eangullo@yahoo.es; silvia.tejada@uib.es; iabetego@unav.es; mazulet@unav.es; antoni.sureda@uib.es; jalfredo.martinez@imdea.org; pep.tur@uib.es RI ; Tejada, Silvia/L-7297-2014; Zulet, M Angeles/H-1317-2017; Tur, Josep/AAE-5748-2020; Sureda, Antoni/N-9588-2019; Martínez, J./K-8709-2014; Abete, Itziar/H-4827-2017; Abbate, Manuela/HCI-8844-2022 OI Barbería, María/0000-0001-5617-4729; Zulet, M Angeles/0000-0002-3926-0892; Tur, Josep/0000-0002-6940-0761; , Antoni/0000-0001-8656-6838; GOMEZ COBO, CRISTINA/0000-0002-9776-4730; Abete, Itziar/0000-0002-6475-5387; Abbate, Manuela/0000-0001-9905-2414 FU Fundacio La Marato TV3 (Spain) [201630.10]; Instituto de Salud Carlos III through the Fondo de Investigacion para la Salud [PI14/00636, PI17/01827]; Instituto de Salud Carlos III through the Fondo de Investigacion para la Salud (CIBEROBN) [CB12/03/30038]; Instituto de Salud Carlos III through the Fondo de Investigacion para la Salud (Proyecto Intramural CIBER) [OBN18PI03]; Health Department of the Government of Navarra [61/2015]; European Regional Development Fund [35/2011, 23/2012]; EU-COST Action [CA16112]; IDISBA Grant (FOLIUM); IDISBA Grant (PRIMUS); IDISBA Grant (SYNERGIA); IDISBA Grant (LIBERI); Spanish Ministry of Education FX Fundacio La Marato TV3 (Spain) project ref. 201630.10. Instituto de Salud Carlos III through the Fondo de Investigacion para la Salud (Projects PI14/00636 and PI17/01827, and CIBEROBN CB12/03/30038, and Proyecto Intramural CIBER OBN18PI03), Health Department of the Government of Navarra (61/2015), and Grant of support to research groups no. 35/2011 and 23/2012 (Balearic Islands Government), which are co-funded by the European Regional Development Fund. Other funding received: EU-COST Action CA16112, and IDISBA Grants (FOLIUM, PRIMUS, SYNERGIA, and LIBERI). Catalina M. Mascaro received an FPU PhD Grant from the Spanish Ministry of Education. The funding sponsors had no role in the design of the study, in the collection, analyses, or interpretation of the data; in the writing of the manuscript, or in the decision to publish the results. 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WOS:000622948900001 PM 33672073 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Gao, VC Long, MT Singh, SR Kim, Y Zhang, XH Rogers, G Jacques, PF Levy, D Ma, JT AF Gao, Vincent Long, Michelle T. Singh, Shridhar R. Kim, Youjin Zhang, Xuehong Rogers, Gail Jacques, Paul F. Levy, Daniel Ma, Jiantao TI A Healthy Diet is Associated with a Lower Risk of Hepatic Fibrosis SO JOURNAL OF NUTRITION LA English DT Article DE DASH score; hepatic fibrosis; hepatic fat; liver fat; nonalcoholic fatty liver disease; vibration-controlled transient elastography; NHANES; Framingham Heart Study ID FATTY LIVER-DISEASE; CORONARY-HEART-DISEASE; MEDITERRANEAN DIET; PHYSICAL-ACTIVITY; DIAGNOSIS; STROKE; COHORT; NAFLD AB Background: Higher diet quality is associated with a lower risk of NAFLD. Objectives: We examined the relationship between diet quality and hepatic fibrosis. Methods: We analyzed cross-sectional associations between 3 a priori diet quality scores-the Dietary Approaches to Stop Hypertension (DASH) score, the Alternative Healthy Eating Index (AHEI), and a modified Mediterranean-style Diet Score (MDS)-and hepatic fat [controlled attenuation parameter (CAP)] and fibrosis [liver stiffness measurement (LSM)] measured by vibration-controlled transient elastography (VCTE) in 2532 Framingham Heart Study (FHS) participants and 3295 participants of the National Health and Nutrition Examination Survey (NHANES). Results: Higher diet quality scores were associated with lower LSM in both FHS and NHANES after adjustment for demographic and lifestyle factors. Additional adjustment for CAP or BMI attenuated the observed associations. Association strength was similar across all 3 diet quality scores. Fixed-effect meta-analysis demonstrated that, under CAP-adjusted models, the LSM decreases associated with 1-SD increase of the DASH, AHEI, and MDS scores were 2% (95% CI: 0.7%, 3.3%; P = 0.002), 2% (95% CI: 0.7%, 3.3%; P = 0.003), and 1.7% (95% CI: 0.7%, 2.6%; P = 0.001), respectively, whereas in the meta-analysis of BMI-adjusted models, LSM reductions associated with 1-SD increase of the DASH, AHEI, and MDS scores were 2.2% (95% CI: -0.1%, 2.2%; P = 0.07), 1.5% (95% CI: 0.3%, 2.7%; P = 0.02), and 0.9 (95% CI: -0.1%, 1.9%; P = 0.07), respectively. Conclusions: We demonstrated associations of higher diet quality with favorable hepatic fat and fibrosis measures. Our data suggest that a healthy diet may reduce the likelihood of obesity and hepatic steatosis as well as the progression of steatosis to fibrosis. C1 [Gao, Vincent] Emory Univ, Emory Coll Arts & Sci, Atlanta, GA USA. [Long, Michelle T.] Boston Univ, Boston Med Ctr, Sect Gastroenterol, Sch Med, Boston, MA USA. [Singh, Shridhar R.] UMass Chan Med Sch, Dept Ophthalmol & Visual Sci, Worcester, MA USA. [Kim, Youjin; Ma, Jiantao] Tufts Univ, Friedman Sch Nutr Sci & Policy, Div Nutr Epidemiol & Data Sci, Boston, MA 02111 USA. [Zhang, Xuehong] Brigham & Womens Hosp, Dept Med, Channing Div Network Med, Boston, MA USA. [Zhang, Xuehong] Harvard Med Sch, Boston, MA USA. [Zhang, Xuehong] Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA. [Rogers, Gail] Jean Mayer USDA Human Nutr Res Ctr Aging, Epidemiol, Boston, MA USA. [Jacques, Paul F.] Jean Mayer USDA Human Nutr Res Ctr Aging, Nutr Epidemiol, Boston, MA USA. [Levy, Daniel] NHLBI, Populat Sci Branch, NIH, Bethesda, MD USA. [Levy, Daniel] Framingham Heart Dis Epidemiol Study, Framingham, MA USA. C3 Emory University; Boston University; Boston Medical Center; University of Massachusetts System; UMass Chan Medical School; University of Massachusetts Worcester; Tufts University; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard University; Harvard Medical School; Harvard University; Harvard T.H. Chan School of Public Health; United States Department of Agriculture (USDA); United States Department of Agriculture (USDA); National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI); Framingham Heart Study RP Ma, JT (通讯作者)，Tufts Univ, Friedman Sch Nutr Sci & Policy, Div Nutr Epidemiol & Data Sci, Boston, MA 02111 USA. EM jiantao.ma@tufts.edu RI Levy, Daniel/ABF-6873-2021; Zhang, Xuehong/E-6219-2012; Long, Michelle/H-3801-2019 OI Levy, Daniel/0000-0003-1843-8724; Singh, Shridhar/0000-0002-1354-4029; Ma, Jiantao/0000-0001-7478-7203; Gao, Vincent/0000-0002-1311-001X; FU NIH [75N92019 D00031, N01-HC-25195]; [HHSN268201500001I]; [K22HL135075]; National Heart Lung and Blood Institute [ZIAHL006001, K22HL135075] Funding Source: NIH RePORTER FX The Framingham Heart Study was supported by NIH contracts (N01-HC-25195, HHSN268201500001I, and 75N92019 D00031). JM was supported by K22HL135075. 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Nutr. PD MAY PY 2023 VL 153 IS 5 BP 1587 EP 1596 DI 10.1016/j.tjnut.2023.03.038 EA MAY 2023 PG 10 WC Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Nutrition & Dietetics GA I7BO3 UT WOS:001004304400001 PM 37023964 OA Green Submitted DA 2026-02-02 ER PT J AU Mobasheri, N Ghahremani, L Abarghooee, EF Hassanzadeh, J AF Mobasheri, Narges Ghahremani, Leila Fallahzadeh Abarghooee, Ebrahim Hassanzadeh, Jafar TI Lifestyle Intervention for Patients with Nonalcoholic Fatty Liver Disease: A Randomized Clinical Trial Based on the Theory of Planned Behavior SO BIOMED RESEARCH INTERNATIONAL LA English DT Article ID PHYSICAL-ACTIVITY; MEDITERRANEAN DIET; EPIDEMIOLOGY; ASSOCIATION; POPULATION; MANAGEMENT; ATTITUDES AB Introduction. Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease, accounting for about 25% and 33% of the world's adult population and Iranians, respectively. There is currently no effective therapeutic agent available for the treatment of NAFLD. However, lifestyle modifications aimed at weight loss have been introduced as a cornerstone of NAFLD management. The aim of the present study was to evaluate the effect of educational intervention on lifestyle and anthropometric indices in patients with NAFLD. Methods. The randomized controlled clinical trial was performed on 87 overweight or obese patients with NAFLD, including intervention (n=42) and control (n=45) groups. The intervention received 8 training sessions based on theory of planned behavior (TPB), while the control groups received nutritional and physical activity recommendations from their internal specialist and nutritionist. Analyses were carried out based on data collected from TPB constructs and anthropometric indices (weight, body mass index (BMI), waist size, and waist-hip ratio (WHR)) at three stages (before intervention and two and 12 weeks after the intervention), as well as data obtained from liver enzymes (alanine aminotransferase (ALT) and aspartate aminotransferase (AST)), and ultrasound-based grading of NAFLD at two stages (before and 12 weeks after the intervention). Results. After the intervention, a significant difference was found between the intervention and control groups, resulting in the increased mean scores of TPB constructs, decreased liver enzymes, and decreased degree of NAFLD ultrasound. In addition, the intervention group experienced more activity and healthy diet as compared with the control group. Anthropometric indices showed only a significant decrease in BMI in the intervention group (p < 0.05). Conclusions. TPB-based training, as compared with traditional training, is a more effective and cost-effective strategy for altering nutritional behavior and physical activity of patients with NAFLD. C1 [Mobasheri, Narges; Ghahremani, Leila] Shiraz Univ Med Sci, Fac Hlth, Dept Hlth Promot & Educ, POB 75541-71536, Shiraz, Iran. [Fallahzadeh Abarghooee, Ebrahim] Shiraz Univ Med Sci, Sch Med, Dept Persian Med, Shiraz, Iran. [Hassanzadeh, Jafar] Shiraz Univ Med Sci, Sch Hlth, Dept Epidemiol, Shiraz, Iran. C3 Shiraz University of Medical Science; Shiraz University of Medical Science; Shiraz University of Medical Science RP Ghahremani, L (通讯作者)，Shiraz Univ Med Sci, Fac Hlth, Dept Hlth Promot & Educ, POB 75541-71536, Shiraz, Iran. EM mobasheri.mn@gmail.com; ghahramanl@sums.ac.ir; fallahzadeh80@gmail.com; jafarabolhasan@yahoo.com RI ghahremani, leila/D-9626-2012; Mobasheri, Narges/MGT-8531-2025; hassanzadeh, jafar/Q-5735-2017 OI Mobasheri, Narges/0000-0002-3098-1810; CR Ajzen I., 2006, Constructing a Theory of Planned Behavior questionnaire, DOI DOI 10.1016/0749-5978(91)90020-T Ajzen I., 2019, ICEK AJZEN THEORY PL Ajzen I., 2020, The handbook of behavior change, P17, DOI [10.1017/9781108677318.002, DOI 10.1017/9781108677318.002] Akhlaghi M, 2020, J DIABETES METAB DIS, V19, P575, DOI 10.1007/s40200-019-00475-2 Albarracin D, 2018, ANNU REV PSYCHOL, V69, P299, DOI 10.1146/annurev-psych-122216-011911 Anania C, 2018, WORLD J GASTROENTERO, V24, P2083, DOI 10.3748/wjg.v24.i19.2083 [Anonymous], 2005, Guidelines for Data Processing and Analysis of the International Physical Activity Questionnaire (IPAQ) Anushiravani Amir, 2019, Middle East J Dig Dis, V11, P189, DOI [10.15171/mejdd.2019.147, 10.15171/mejdd.2019.147, 10.15171/middle%20east%20j%20di.v11i4.2171] Argo CK, 2009, CLIN LIVER DIS, V13, P511, DOI 10.1016/j.cld.2009.07.005 Bellentani S, 2017, LIVER INT, V37, P81, DOI 10.1111/liv.13299 Bullón-Vela V, 2020, NUTRITION, V71, DOI 10.1016/j.nut.2019.110620 Byrne CD, 2015, J HEPATOL, V62, pS47, DOI 10.1016/j.jhep.2014.12.012 Calabrese FM, 2022, NUTRIENTS, V14, DOI 10.3390/nu14091773 Chalasani N, 2018, HEPATOLOGY, V67, P328, DOI [10.1002/hep.29367, 10.1038/s42255-021-00344-4] Chevance G, 2017, PSYCHOL HEALTH MED, V22, P319, DOI 10.1080/13548506.2016.1159705 Choi HI, 2022, BMC PUBLIC HEALTH, V22, DOI 10.1186/s12889-022-13128-6 Close MA, 2018, NUTR FOOD SCI, V48, P365, DOI 10.1108/NFS-06-2017-0123 Conner M., 2010, Handbook of behavioral medicine Cottrell R.R., 2010, HLTH PROMOTION ED RE Gholamnia-Shirvani Z, 2018, WOMEN HEALTH, V58, P834, DOI 10.1080/03630242.2017.1342739 Golovaty I, 2020, J NUTR, V150, P91, DOI 10.1093/jn/nxz212 Hajian-Tilaki K, 2014, DIABETES METAB SYND, V8, P170, DOI 10.1016/j.dsx.2014.04.012 Jeihooni AK, 2022, BMC WOMENS HEALTH, V22, DOI 10.1186/s12905-022-01593-5 Kenneally S, 2017, BMJ OPEN GASTROENTER, V4, DOI 10.1136/bmjgast-2017-000139 Kennedy-Martin T, 2018, J PATIENT-REP OUTCOM, V2, DOI 10.1186/s41687-018-0052-7 Jeihooni AK, 2021, BMC CARDIOVASC DISOR, V21, DOI 10.1186/s12872-021-02399-3 Lazarus JV, 2020, J HEPATOL, V72, P14, DOI 10.1016/j.jhep.2019.08.027 Mahdavi-Roshan M, 2018, MEDITERR J NUTR META, V11, P323, DOI 10.3233/MNM-18205 Mascaró CM, 2022, NUTRIENTS, V14, DOI 10.3390/nu14091813 Mazloomy-Mahmoodabad SS, 2017, ARYA ATHEROSCLER, V13 Michie S, 2013, ANN BEHAV MED, V46, P81, DOI 10.1007/s12160-013-9486-6 MohammadniaMotlagh K, 2022, BMC WOMENS HEALTH, V22, DOI 10.1186/s12905-022-01608-1 NCSS L, 2017, PASS 15 Power Analysis and Sample Size Software Kaysville Parrott MW, 2008, PSYCHOL SPORT EXERC, V9, P511, DOI 10.1016/j.psychsport.2007.07.002 Piercy KL, 2018, JAMA-J AM MED ASSOC, V320, P2020, DOI 10.1001/jama.2018.14854 Saeed N, 2019, NUTRIENTS, V11, DOI 10.3390/nu11123064 Sanaeinasab H, 2020, APPL PSYCHOL-HLTH WE, V12, P101, DOI 10.1111/aphw.12175 Sánchez-Villegas A, 2018, PREVENTION OF CARDIOVASCULAR DISEASE THROUGH THE MEDITERRANEAN DIET, P1, DOI 10.1016/B978-0-12-811259-5.00001-9 Shafieinia Masoud, 2016, Asian J Sports Med, V7, pe31534, DOI [10.5812/asjsm.31534, 10.5812/asjsm.31534] Wasserkampf A, 2014, HEALTH EDUC RES, V29, P941, DOI 10.1093/her/cyu060 Xiao ML, 2020, PUBLIC HEALTH NUTR, V23, P674, DOI 10.1017/S1368980019002568 York LW, 2009, ANNU REV NUTR, V29, P365, DOI 10.1146/annurev-nutr-070208-114232 Younossi Z, 2018, NAT REV GASTRO HEPAT, V15, P11, DOI 10.1038/nrgastro.2017.109 Younossi Z, 2016, GASTROENTEROLOGY, V150, P1778, DOI 10.1053/j.gastro.2016.03.005 Younossi ZM, 2019, TRANSPLANTATION, V103, P22, DOI 10.1097/TP.0000000000002484 NR 45 TC 11 Z9 13 U1 1 U2 11 PU WILEY PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 2314-6133 EI 2314-6141 J9 BIOMED RES INT JI Biomed Res. 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PD SEP 12 PY 2022 VL 2022 AR 3465980 DI 10.1155/2022/3465980 PG 10 WC Biotechnology & Applied Microbiology; Medicine, Research & Experimental WE Science Citation Index Expanded (SCI-EXPANDED) SC Biotechnology & Applied Microbiology; Research & Experimental Medicine GA 5C8BX UT WOS:000864480200014 PM 36132088 OA Green Submitted, hybrid DA 2026-02-02 ER PT J AU Porcu, C Sideri, S Martini, M Cocomazzi, A Galli, A Tarantino, G Balsano, C AF Porcu, Cristiana Sideri, Silvia Martini, Maurizio Cocomazzi, Alessandra Galli, Andrea Tarantino, Giovanni Balsano, Clara TI Oleuropein Induces AMPK-Dependent Autophagy in NAFLD Mice, Regardless of the Gender SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES LA English DT Article DE autophagy; AMPK; mTOR; oleuropein; phenolic compound; nutraceutical; Mediterranean diet; olive oil; liver steatosis; NAFLD ID FATTY LIVER-DISEASE; CELL-DEATH; OLIVE; METABOLISM; MECHANISMS; EXPRESSION; APOPTOSIS; PATHWAYS; TARGET; DRUGS AB Oleuropein (Ole) is one of the most plentiful phenolic compounds with antioxidant, anti-inflammatory, anti-atherogenic, hypoglycemic and hypolipidemic effects. The aim of our study was to establish whether the positive Ole-related effects on liver steatosis could be associated with autophagy. Female and male C57BL/6J mice were fed normal diet (ND) or high-fat diet (HFD) for eight weeks, and Ole was added or not for the following eight weeks. The autophagy-related proteins Akt, mTOR, AMPK, ULK1, Beclin-1, LC3B and p62/Sqstm1 were analyzed. Interestingly, Ole induced a different regulation of the Akt/mTOR pathway in female compared to male mice, but was able to activate the autophagic process in ND and HFD mice through AMPK-dependent phosphorylation of ULK1 at Ser555, regardless of the gender. Our work reveals the ability of Ole to induce, in liver of ND and HFD mice, autophagy independently by gender-specific mTOR activation. We highlight Ole as a novel therapeutic approach to counteract unhealthy diet-related liver steatosis by targeting autophagy. C1 [Porcu, Cristiana; Sideri, Silvia; Balsano, Clara] F Balsano Fdn, Via Giovanni Battista Martini 6, I-00198 Rome, Italy. [Porcu, Cristiana; Sideri, Silvia; Balsano, Clara] Univ Laquila, MESVA Dept, Piazza S Salvatore Tommasi 1, I-67100 Laquila, Italy. [Martini, Maurizio; Cocomazzi, Alessandra] Univ Cattolica Sacro Cuore Rome, IRCCS, Fdn Policlin A Gemelli, Rome, Italy. [Galli, Andrea] Univ Florence, Gastroenterol Unit, Dept Expt & Clin Biomed Sci Mario Serio, I-50139 Florence, Italy. [Tarantino, Giovanni] Univ Naples Federico II, Med Sch Naples, Dept Clin Med & Surg, I-80131 Naples, Italy. C3 University of L'Aquila; Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli; University of Florence; University of Naples Federico II RP Balsano, C (通讯作者)，F Balsano Fdn, Via Giovanni Battista Martini 6, I-00198 Rome, Italy.; Balsano, C (通讯作者)，Univ Laquila, MESVA Dept, Piazza S Salvatore Tommasi 1, I-67100 Laquila, Italy. EM cristiana.porcu@live.it; silviasideri@gmail.com; maurizio.martini@unicatt.it; alessandra.cocomazzi@libero.it; a.galli@dfc.unifi.it; tarantin@unina.it; clara.balsano@cc.univaq.it RI Balsano, Clara/MCY-5404-2025; Galli, Anea/AAC-1623-2019; Giovanni, Tarantino/AAW-2007-2021; Martini, Maurizio/AAB-1564-2019 OI Balsano, Clara/0000-0002-9615-7031; Galli, Anea/0000-0001-5416-6290; Sideri, Silvia/0000-0002-0937-0257; Giovanni, Tarantino/0000-0001-7751-2715; Porcu, Cristiana/0000-0001-7415-7615; Martini, Maurizio/0000-0002-6260-6310 FU Francesco Balsano Foundation FX This research was supported by the Francesco Balsano Foundation. 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TI The Impact of Dietary Patterns and Nutrition in Nonalcoholic Fatty Liver Disease SO GASTROENTEROLOGY CLINICS OF NORTH AMERICA LA English DT Article DE Nonalcoholic fatty liver disease; Diet; Macronutrients; Micronutrients; Nutrition; Dietary recommendations ID MEDITERRANEAN DIET; HEPATIC STEATOSIS; VITAMIN-D; INSULIN-RESISTANCE; DARK CHOCOLATE; DOUBLE-BLIND; LIFE-STYLE; METABOLIC SYNDROME; LOW-CARBOHYDRATE; VEGETARIAN DIET C1 [Kim, Ahyoung; Krishnan, Arunkumar; Hamilton, James P.; Woreta, Tinsay A.] Johns Hopkins Univ, Sch Med, Div Gastroenterol & Hepatol, Baltimore, MD USA. C3 Johns Hopkins University RP Woreta, TA (通讯作者)，600 North Wolfe St,Hal 407, Baltimore, MD 21287 USA. 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Clin. North Am. PD MAR PY 2021 VL 50 IS 1 SI SI BP 217 EP 241 DI 10.1016/j.gtc.2020.10.013 EA JAN 2021 PG 25 WC Gastroenterology & Hepatology WE Science Citation Index Expanded (SCI-EXPANDED) SC Gastroenterology & Hepatology GA QE0VY UT WOS:000615927000017 PM 33518166 DA 2026-02-02 ER PT J AU Pérez-Guisado, J Muñoz-Serrano, A AF Perez-Guisado, Joaquin Munoz-Serrano, Andres TI The Effect of the Spanish Ketogenic Mediterranean Diet on Nonalcoholic Fatty Liver Disease: A Pilot Study SO JOURNAL OF MEDICINAL FOOD LA English DT Article DE ketogenic diet; low carbohydrate diet; metabolic syndrome; nonalcoholic fatty liver disease; protein diet; "Spanish Ketogenic Mediterranean Diet'' ID METABOLIC SYNDROME; WEIGHT-LOSS; INSULIN-RESISTANCE; UNITED-STATES; OBESITY; STEATOHEPATITIS; ASSOCIATION; CARBOHYDRATE; PREVALENCE AB The "Spanish Ketogenic Mediterranean Diet'' (SKMD) has been shown to be an effective and safe way to cure patients suffering from metabolic syndrome (MS). Keeping in mind that nonalcoholic fatty liver disease (NAFLD) is closely associated with MS, the purpose of this study was to evaluate the potential therapeutic properties under free living conditions of the SKMD in patients with MS (following the International Diabetes Federation [IDF] consensus guidelines) and NAFLD (suspected by using a cutoff value of alanine aminotransferase [ALT] levels of >40U/L and confirmed by abdominal ultrasonography) over a 12-week period. A prospective study was carried out in 14 obese men meeting the inclusion criteria and whose body mass index (BMI) and age were 36.58 +/- 0.54 kg/m(2) and 41.18 +/- 2.28 years, respectively. Statistical differences between the parameters studied before and after administration of the SKMD (week 0 and 12) were analyzed by paired Student's t test (continuous variables) and the chi(2) test (discontinuous variables). P < .05 was considered statistically significant. There was an extremely significant (P < .001) improvement in body weight (from 109.79 kg to 95.86 kg), low-density lipoprotein-cholesterol (from 123.43 mg/dL to 100.35 mg/dL), ALT (from 71.92 U/L to 37.07 U/L), aspartate aminotransferase (from 47.71U/L to 29.57 U/L), steatosis degree (complete fatty liver regression was observed in 21.4% of the patients, and an overall reduction was found in 92.86% of the patients), and all the parameters studied associated with the MS: BMI (from 36.99 kg/m(2) to 32.42 kg/m(2)), waist circumference (from 114.01 cm to 98.59 cm), fasting plasma glucose (from 118.57 mg/dL to 90.14 mg/dL), triacylglycerols (from 232.64 mg/dL to 111.21 mg/dL), high-density lipoprotein-cholesterol (HDLc) (from 42.81 mg/dL to 58.71 mg/dL), systolic blood pressure (from 142.86 mm Hg to 125.36 mm Hg), and diastolic blood pressure (from 89.64 mm Hg to 77.86 mm Hg). After the diet all the subjects were free of MS according to the IDF definition, and 100% of them had normal triacylglycerols and HDLc levels, in spite of the fact that 100% of them still had a BMI of >30 kg/m(2). We conclude that the SKMD could be an effective and safe way to treat patients suffering from MS and the associated NAFLD. C1 [Perez-Guisado, Joaquin; Munoz-Serrano, Andres] Univ Cordoba, Dept Genet, E-14071 Cordoba, Spain. C3 Universidad de Cordoba RP Pérez-Guisado, J (通讯作者)，Univ Cordoba, Dept Genet, Edificio Gregorio Mendel,Campus Rabanales, E-14071 Cordoba, Spain. EM pv1peguj@uco.es CR Accurso A, 2008, NUTR METAB, V5, DOI 10.1186/1743-7075-5-9 ANDERSEN T, 1984, INT J OBESITY, V8, P97 Angulo P, 1999, HEPATOLOGY, V30, P1356, DOI 10.1002/hep.510300604 Angulo P, 2002, NEW ENGL J MED, V346, P1221, DOI 10.1038/nrdp.2015.80 [Anonymous], 2005, The IDF consensus worldwide definition of the metabolic syndrome Assy N, 2000, DIGEST DIS SCI, V45, P1929, DOI 10.1023/A:1005661516165 Assy N, 2009, WORLD J GASTROENTERO, V15, P1809, DOI 10.3748/wjg.15.1809 Clark JM, 2003, AM J GASTROENTEROL, V98, P960, DOI [10.1016/S0002-9270(03)00265-X, 10.1111/j.1572-0241.2003.07486.x] García-Monzón C, 2000, J HEPATOL, V33, P716, DOI 10.1016/S0168-8278(00)80301-3 Graif M, 2000, INVEST RADIOL, V35, P319, DOI 10.1097/00004424-200005000-00006 Hamaguchi M, 2007, AM J GASTROENTEROL, V102, P2708, DOI 10.1111/j.1572-0241.2007.01526.x Knobler H, 1999, QJM-MON J ASSOC PHYS, V92, P73, DOI 10.1093/qjmed/92.2.73 Lyznicki JM, 2001, AM FAM PHYSICIAN, V63, P2185 Marceau P, 1999, J CLIN ENDOCR METAB, V84, P1513, DOI 10.1210/jc.84.5.1513 Marchesini G, 1999, AM J MED, V107, P450, DOI 10.1016/S0002-9343(99)00271-5 Pérez-Guisado J, 2008, ARCH LATINOAM NUTR, V58, P126 Pérez-Guisado J, 2011, J MED FOOD, V14, P681, DOI 10.1089/jmf.2010.0137 Pérez-Guisado J, 2008, NUTR J, V7, DOI 10.1186/1475-2891-7-30 Pérez-Guisado J, 2008, ARCH LATINOAM NUTR, V58, P323 PEREZGUISADO J, 2007, INTERNET J NUTR WELL, V4, P2 Ruhl CE, 2003, GASTROENTEROLOGY, V124, P71, DOI 10.1053/gast.2003.50004 Tendler D, 2007, DIGEST DIS SCI, V52, P589, DOI 10.1007/s10620-006-9433-5 Tzima N, 2009, NUTR METAB, V6, DOI 10.1186/1743-7075-6-30 Volek Jeff S, 2005, Nutr Metab (Lond), V2, P31, DOI 10.1186/1743-7075-2-31 Wieckowska A, 2007, HEPATOLOGY, V46, P582, DOI 10.1002/hep.21768 Zhu FS, 2008, WORLD J GASTROENTERO, V14, P6395, DOI 10.3748/wjg.14.6395 NR 26 TC 65 Z9 74 U1 0 U2 15 PU MARY ANN LIEBERT INC PI NEW ROCHELLE PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA SN 1096-620X J9 J MED FOOD JI J. Med. Food PD JUL-AUG PY 2011 VL 14 IS 7-8 BP 677 EP 680 DI 10.1089/jmf.2011.0075 PG 4 WC Chemistry, Medicinal; Food Science & Technology; Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Pharmacology & Pharmacy; Food Science & Technology; Nutrition & Dietetics GA 792TU UT WOS:000292774100001 PM 21688989 DA 2026-02-02 ER PT J AU Fotakis, C Amanatidou, AI Kafyra, M Andreou, V Kalafati, IP Zervou, M Dedoussis, GV AF Fotakis, Charalambos Amanatidou, Athina I. Kafyra, Maria Andreou, Vasiliki Kalafati, Ioanna Panagiota Zervou, Maria Dedoussis, George V. TI Circulatory Metabolite Ratios as Indicators of Lifestyle Risk Factors Based on a Greek NAFLD Case-Control Study SO NUTRIENTS LA English DT Article DE MASLD; serum; NMR metabolomics; lifestyle; obesity; metabolite biomarkers ID FATTY LIVER-DISEASE; BRANCHED-CHAIN; INSULIN-RESISTANCE; OBESE; NUTRITION; QUALITY; HEALTH; IMPACT AB An ensemble of confounding factors, such as an unhealthy diet, obesity, physical inactivity, and smoking, have been linked to a lifestyle that increases one's susceptibility to chronic diseases and early mortality. The circulatory metabolome may provide a rational means of pinpointing the advent of metabolite variations that reflect an adherence to a lifestyle and are associated with the occurrence of chronic diseases. Data related to four major modifiable lifestyle factors, including adherence to the Mediterranean diet (estimated on MedDietScore), body mass index (BMI), smoking, and physical activity level (PAL), were used to create the lifestyle risk score (LS). The LS was further categorized into four groups, where a higher score group indicates a less healthy lifestyle. Drawing on this, we analyzed 223 NMR serum spectra, 89 MASLD patients and 134 controls; these were coupled to chemometrics to identify "key" features and understand the biological processes involved in specific lifestyles. The unsupervised analysis verified that lifestyle was the factor influencing the samples' differentiation, while the supervised analysis highlighted metabolic signatures. Tau he metabolic ratios of alanine/formic acid and leucine/formic acid, with AUROC > 0.8, may constitute discriminant indexes of lifestyle. On these grounds, this research contributed to understanding the impact of lifestyle on the circulatory metabolome and highlighted "prudent lifestyle" biomarkers. C1 [Fotakis, Charalambos; Andreou, Vasiliki; Zervou, Maria] Natl Hellen Res Fdn, Inst Chem Biol, 48 Vas Constantinou Ave, Athens 11635, Greece. [Amanatidou, Athina I.; Kafyra, Maria; Kalafati, Ioanna Panagiota; Dedoussis, George V.] Harokopio Univ Athens, Sch Hlth Sci & Educ, Dept Nutr & Dietet, Athens 17671, Greece. C3 National Hellenic Research Foundation; Harokopio University Athens RP Zervou, M (通讯作者)，Natl Hellen Res Fdn, Inst Chem Biol, 48 Vas Constantinou Ave, Athens 11635, Greece.; Dedoussis, GV (通讯作者)，Harokopio Univ Athens, Sch Hlth Sci & Educ, Dept Nutr & Dietet, Athens 17671, Greece. EM bfotakis@yahoo.com; aamanatid@gmail.com; mariakaf@hua.gr; vicky.x.a@hotmail.com; nkalafati@gmail.com; mzervou@eie.gr; dedousi@hua.gr RI ; Kalafati, Ioanna Panagiota/AAJ-2287-2020; Dedoussis, George/AAN-7252-2021 OI Kafyra, Maria/0009-0005-9665-0829; fotakis, Charalambos/0000-0002-3544-0829; Zervou, Maria/0000-0001-5963-4954; Kalafati, Ioanna Panagiota/0000-0001-5572-7491; Amanatidou, Athina/0000-0002-7303-5664; Dedoussis, George/0000-0002-7798-6221 FU European Union and Greek national funds [MIS 5002550]; Operational Programme "Competitiveness, Entrepreneurship and Innovation" FX We would like to acknowledge the support of this work related to NMR infrastructure by the project "INSPIRED" (MIS 5002550), under the Action "Reinforcement of the Research and Innovation Infrastructure", funded by the Operational Programme "Competitiveness, Entrepreneurship and Innovation" (NSRF 2014-2020). 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Science Citation Index Expanded (SCI-EXPANDED) SC Nutrition & Dietetics GA PA2T3 UT WOS:001211300800001 PM 38674925 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Vilar-Gomez, E Athinarayanan, SJ Adams, RN Hallberg, SJ Bhanpuri, NH McKenzie, AL Campbell, WW McCarter, JP Phinney, SD Volek, JS Chalasani, N AF Vilar-Gomez, Eduardo Athinarayanan, Shaminie J. Adams, Rebecca N. Hallberg, Sarah J. Bhanpuri, Nasir H. McKenzie, Amy L. Campbell, Wayne W. McCarter, James P. Phinney, Stephen D. Volek, Jeff S. Chalasani, Naga TI Post hoc analyses of surrogate markers of non-alcoholic fatty liver disease (NAFLD) and liver fibrosis in patients with type 2 diabetes in a digitally supported continuous care intervention: an open-label, non-randomised controlled study SO BMJ OPEN LA English DT Article ID LIFE-STYLE MODIFICATION; ALANINE AMINOTRANSFERASE LEVELS; LOW-CARBOHYDRATE; KETOGENIC DIET; WEIGHT-LOSS; MEDITERRANEAN DIET; HEPATIC STEATOSIS; CONTROLLED-TRIAL; BODY-WEIGHT; RESTRICTION AB Objective One year of comprehensive continuous care intervention (CCI) through nutritional ketosis improves glycosylated haemoglobin(HbA1c), body weight and liver enzymes among patients with type 2 diabetes (T2D). Here, we report the effect of the CCI on surrogate scores of non-alcoholic fatty liver disease (NAFLD) and liver fibrosis. Methods This was a non-randomised longitudinal study, including adults with T2D who were self-enrolled to the CCI (n=262) or to receive usual care (UC, n=87) during 1 year. An NAFLD liver fat score (N-LFS) >-0.640 defined the presence of fatty liver. An NAFLD fibrosis score (NFS) of >0.675 identified subjects with advanced fibrosis. Changes in N-LFS and NFS at 1 year were the main endpoints. Results At baseline, NAFLD was present in 95% of patients in the CCI and 90% of patients in the UC. At 1 year, weight loss of >= 5% was achieved in 79% of patients in the CCI versus 19% of patients in UC (p<0.001). N-LFS mean score was reduced in the CCI group (-1.95 +/- 0.22, p<0.001), whereas it was not changed in the UC (0.47 +/- 0.41, p=0.26) (CCI vs UC, p<0.001). NFS was reduced in the CCI group (-0.65 +/- 0.06, p<0.001) compared with UC (0.26 +/- 0.11, p=0.02) (p<0.001 between two groups). In the CCI group, the percentage of individuals with a low probability of advanced fibrosis increased from 18% at baseline to 33% at 1 year (p<0.001). Conclusions One year of a digitally supported CCI significantly improved surrogates of NAFLD and advanced fibrosis in patients with T2D. Trial registration number NCT02519309; Results. C1 [Vilar-Gomez, Eduardo; Chalasani, Naga] Indiana Univ Sch Med, Div Gastroenterol & Hepatol, Indianapolis, IN 46202 USA. [Athinarayanan, Shaminie J.; Adams, Rebecca N.; Hallberg, Sarah J.; Bhanpuri, Nasir H.; McKenzie, Amy L.; McCarter, James P.; Phinney, Stephen D.; Volek, Jeff S.] Virta Hlth, San Francisco, CA USA. [Hallberg, Sarah J.] Indiana Univ Hlth Arnett, Lafayette, IN USA. [Campbell, Wayne W.] Purdue Univ, Dept Nutr Sci, W Lafayette, IN 47907 USA. [McCarter, James P.] Washington Univ, Sch Med, Dept Genet, St Louis, MO 63110 USA. [Volek, Jeff S.] Ohio State Univ, Dept Human Sci, Columbus, OH 43210 USA. C3 Indiana University System; Indiana University Bloomington; Indiana University Health; IU Health Arnett Hospital; Purdue University System; Purdue University; Washington University (WUSTL); University System of Ohio; Ohio State University RP Chalasani, N (通讯作者)，Indiana Univ Sch Med, Div Gastroenterol & Hepatol, Indianapolis, IN 46202 USA. EM nchalasa@iu.edu RI ; Athinarayanan, Shaminie/ABH-3703-2020; McKenzie, Amy/I-3706-2014; Vilar, Eduardo/H-8556-2019 OI Campbell, Wayne/0000-0002-7847-7242; Athinarayanan, Shaminie/0000-0001-5427-6748; McKenzie, Amy/0000-0003-4549-5177; McCarter, James/0000-0001-7646-810X FU Virta Health FX Virta Health funded this study. 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In this study, we compared the 1975 Japanese diet, which has been found to have high health benefits, with the 2010 Italian diet, which contributes to the longest life expectancy in Mediterranean countries. Diets were created using one-week menus of the two diets based on FAOSTAT Food Balance Sheets. The diets were prepared, freeze-dried, powdered and fed to mice for 4 weeks to examine their effects on lipid metabolism. In mice fed the Japanese diet, the visceral fat weight was lower, adipocytes were smaller, the liver weight was lower and liver TG tended to be lower than those fed the Italian diet, and little lipid accumulation was observed in hepatocytes of mice fed the Japanese diet. In addition, in mice fed the Japanese diet, the expression levels of genes related to fatty acid synthesis were lower, whereas those of genes related to catabolism of fatty acids and cholesterol were higher than those fed the Italian diet. Therefore, the Japanese diet reduced accumulation of lipids in the white adipose tissue and liver by suppressing fatty acid synthesis and promoting catabolism of fatty acids and cholesterol in the liver, compared to the Italian diet. C1 [Mizowaki, Yui; Sugawara, Saeko; Yamamoto, Kazushi; Sakamoto, Yu; Iwagaki, Yui; Tsuduki, Tsuyoshi] Tohoku Univ, Grad Sch Agr, Lab Food & Biomol Sci, Aoba Ku, 468-1 Aoba, Sendai, Miyagi 9800845, Japan. [Kawakami, Yuki] Okayama Prefectural Univ, Fac Hlth & Welf Sci, 111 Kuboki, Okayama 7191197, Japan. [Igarashi, Miki] RIKEN, Yokohama Branch, Ctr Integrat Med Sci, Lab Metab Homeostasis,Tsurumi Ku, 1-7-22 Suehiro Cho, Yokohama, Kanagawa 2300045, Japan. C3 Tohoku University; Okayama Prefectural University; RIKEN RP Tsuduki, T (通讯作者)，Tohoku Univ, Grad Sch Agr, Lab Food & Biomol Sci, Aoba Ku, 468-1 Aoba, Sendai, Miyagi 9800845, Japan. EM tsudukit@m.tohoku.ac.jp RI Tsuduki, Tsuyoshi/T-2697-2019; Umeda, Miki/HZH-5730-2023 FU Integration research for agriculture and interdisciplinary fields, Ministry of Agriculture, Forestry and Fisheries of Japan; Canon Foundation FX This study was supported by grants from Integration research for agriculture and interdisciplinary fields, Ministry of Agriculture, Forestry and Fisheries of Japan and The Canon Foundation. There are no conflicts of interest. 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Oleo Sci. PD MAY PY 2017 VL 66 IS 5 BP 507 EP 519 DI 10.5650/jos.ess16241 PG 13 WC Chemistry, Applied; Food Science & Technology WE Science Citation Index Expanded (SCI-EXPANDED) SC Chemistry; Food Science & Technology GA ET6QT UT WOS:000400417400010 PM 28458388 OA gold DA 2026-02-02 ER PT J AU Salomone, F Ivancovsky-Wajcman, D Fliss-Isakov, N Webb, M Grosso, G Godos, J Galvano, F Shibolet, O Kariv, R Zelber-Sagi, S AF Salomone, Federico Ivancovsky-Wajcman, Dana Fliss-Isakov, Naomi Webb, Muriel Grosso, Giuseppe Godos, Justyna Galvano, Fabio Shibolet, Oren Kariv, Revital Zelber-Sagi, Shira TI Higher phenolic acid intake independently associates with lower prevalence of insulin resistance and non-alcoholic fatty liver disease SO JHEP REPORTS LA English DT Article DE NAFLD; insulin resistance; fibrosis; diet; phenolic acids; metabolic syndrome ID DIETARY POLYPHENOL INTAKE; INDUCED HEPATIC STEATOSIS; MAJOR FOOD SOURCES; MEDITERRANEAN DIET; HEALTH OUTCOMES; POLISH ARM; RISK; METAANALYSIS; POPULATION; INDEX AB Background & Aims: The inverse association between non-alcoholic fatty liver disease (NAFLD) and diets rich in fruit and vegetables has been demonstrated, but the specific compounds that may be responsible for this association need to be elucidated. The aim of this studywas to test the association between phenolic acid consumption, NAFLD, and insulin resistance (IR). Methods: A cross-sectional cohort of individuals included in a metabolic screening program was studied. Liver steatosis was evaluated by ultrasonography and quantified by the hepatorenal index (HRI); fibrosis was assessed by FibroTest; IR by the sample upper quartile of the homeostatic model assessment score. Dietary intake was measured by a food frequency questionnaire. The phenolic acid content of food was calculated according to Phenol-Explorer. Results: A total of 789 individuals were included (52.6% men, age 58.83 +/- 6.58 years). Higher (above the upper median) phenolic acid intake was inversely associated with the presence of NAFLD (odds ratio [OR] 0.69; 95% CI 0.49-0.98; p = 0.036), higher HRI (OR 0.64; 95% CI 0.45-0.91; p = 0.013) and higher IR (OR 0.61; 95% CI 0.42-0.87; p = 0.007), when adjusted for age, gender, body mass index, and lifestyle factors. Considering specific classes of phenolic acids, higher hydroxybenzoic acid intake was independently associated with lower odds of NAFLD, higher HRI and fibrosis. Higher hydroxycinnamic acid intake was independently associated with lower odds of IR. Conclusion: A higher intake of phenolic acids is associated with a lower prevalence of liver steatosis and IR in a crosssectional study, suggesting a possible protective effect that requires confirmation in prospective studies. (C) 2020 The Author(s). Published by Elsevier B.V. on behalf of European Association for the Study of the Liver (EASL). C1 [Salomone, Federico] Azienda Sanitaria Prov Catania, Div Gastroenterol, Osped Acireale, Catania, Italy. [Ivancovsky-Wajcman, Dana; Zelber-Sagi, Shira] Univ Haifa, Sch Publ Hlth, Haifa, Israel. [Fliss-Isakov, Naomi; Webb, Muriel; Shibolet, Oren; Kariv, Revital; Zelber-Sagi, Shira] Tel Aviv Med Ctr & Sch Med, Dept Gastroenterol, Tel Aviv, Israel. [Webb, Muriel; Shibolet, Oren; Kariv, Revital] Tel Aviv Univ, Sackler Fac Med, Tel Aviv, Israel. [Grosso, Giuseppe; Galvano, Fabio] Univ Catania, Dept Biomed & Biotechnol Sci, Catania, Italy. [Godos, Justyna] Oasi Res Inst, Troina, Italy. C3 University of Haifa; Tel Aviv University; Sackler Faculty of Medicine; Tel Aviv University; Sackler Faculty of Medicine; University of Catania; IRCCS - Oasi Research Institute RP Salomone, F (通讯作者)，Azienda Sanitaria Prov Catania, Via Santa Maria La Grande 5, I-95124 Catania, Italy. EM federicosalomone@rocketmail.com RI Ivancovsky-Wajcman, Dana/HDO-6146-2022; Kariv, Revital/HLW-2074-2023; Grosso, Giuseppe/K-6730-2016; Salomone, Federico/R-6598-2016; Galvano, Fabio/JSL-7451-2023; Godos, Justyna/AAC-1302-2019 OI Salomone, Federico/0000-0001-5264-2935; Galvano, Fabio/0000-0003-0644-0755; Godos, Justyna/0000-0002-5809-5706 FU Research Grants and Fellowships Fund on Food and Nutrition and their Implications on Public Health, The Israeli Ministry of Health FX Research Grants and Fellowships Fund on Food and Nutrition and their Implications on Public Health, The Israeli Ministry of Health. CR Adisakwattana S, 2017, NUTRIENTS, V9, DOI 10.3390/nu9020163 Alam MA, 2016, NUTR METAB, V13, DOI 10.1186/s12986-016-0080-3 American Diabetes Association, 2017, Diabetes Care, V40, pS88, DOI 10.2337/dc17-s012 Annuzzi G, 2014, AM J CLIN NUTR, V99, P463, DOI 10.3945/ajcn.113.073445 [Anonymous], 2019, INT J FOOD SCI NUTR, DOI DOI 10.1080/09637486.2019.1571021 Beáta H, 2014, FREE RADICAL BIO MED, V75, pS33, DOI 10.1016/j.freeradbiomed.2014.10.770 Bozzetto L, 2015, DIABETOLOGIA, V58, P1551, DOI 10.1007/s00125-015-3592-x Buscemi S, 2013, EUR J CLIN NUTR, V67, P1284, DOI 10.1038/ejcn.2013.172 Chang WC, 2015, NUTRIENTS, V7, P9946, DOI 10.3390/nu7125514 Chao J, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0096969 Chiavaroli L, 2019, NUTRIENTS, V11, DOI 10.3390/nu11020338 D'Alessandro A, 2018, INT J FOOD SCI NUTR, V69, P647, DOI 10.1080/09637486.2017.1417978 European Association for the Study of the Liver (EASL), 2016, J Hepatol, V64, P1388, DOI 10.1016/j.jhep.2015.11.004 Godos J., 2017, NFS Journal, V8, P1, DOI [10.1016/j.nfs.2017.06.001, 10.1016/j.nfs.2017.06.001] Godos J, 2017, NUTRIENTS, V9, DOI 10.3390/nu9101069 Godos J, 2017, INT J FOOD SCI NUTR, V68, P750, DOI 10.1080/09637486.2017.1285870 Godos J, 2017, INT J FOOD SCI NUTR, V68, P138, DOI 10.1080/09637486.2016.1221900 Godos J, 2017, INT J FOOD SCI NUTR, V68, P18, DOI 10.1080/09637486.2016.1214239 Grosso G, 2018, EUR J NUTR, V57, P1535, DOI 10.1007/s00394-017-1438-7 Grosso G, 2017, BRIT J NUTR, V118, P60, DOI [10.1017/S0007114517001805, 10.1017/s0007114517001805] Grosso G, 2017, EUR J NUTR, V56, P1409, DOI 10.1007/s00394-016-1187-z Grosso G, 2014, NUTRITION, V30, P1398, DOI 10.1016/j.nut.2014.04.012 Grosso G, 2014, CURR PHARM DESIGN, V20, P5039, DOI 10.2174/1381612819666131206112144 Ham JR, 2016, FOOD FUNCT, V7, P689, DOI 10.1039/c5fo01329a Hsu CC, 2017, ADV NUTR, V8, P253, DOI 10.3945/an.116.013730 Liu WH, 2010, J AGR FOOD CHEM, V58, P10247, DOI 10.1021/jf102379n Ma JT, 2018, GASTROENTEROLOGY, V155, P107, DOI 10.1053/j.gastro.2018.03.038 Ma YJ, 2015, PHARM RES-DORDR, V32, P1200, DOI 10.1007/s11095-014-1526-9 Munteanu M, 2016, ALIMENT PHARM THER, V44, P877, DOI 10.1111/apt.13770 Naowaboot J, 2016, CLIN EXP PHARMACOL P, V43, P242, DOI 10.1111/1440-1681.12514 Nascimento-Souza MA, 2018, EUR J NUTR, V57, P617, DOI 10.1007/s00394-016-1348-0 Panchal SK, 2013, EUR J NUTR, V52, P559, DOI 10.1007/s00394-012-0358-9 Pérez-Jiménez J, 2011, AM J CLIN NUTR, V93, P1220, DOI 10.3945/ajcn.110.007096 Plauth M, 2019, CLIN NUTR, V38, P485, DOI 10.1016/j.clnu.2018.12.022 Poynard T, 2011, BMC GASTROENTEROL, V11, DOI 10.1186/1471-230X-11-39 Rafiei H, 2017, MOL NUTR FOOD RES, V61, DOI 10.1002/mnfr.201600781 Salomone F, 2017, NUTRIENTS, V9, DOI 10.3390/nu9010085 Salomone F, 2016, LIVER INT, V36, P5, DOI 10.1111/liv.12975 Schwingshackl L, 2018, J ACAD NUTR DIET, V118, P74, DOI 10.1016/j.jand.2017.08.024 Shi HT, 2016, CLIN NUTR, V35, P1366, DOI 10.1016/j.clnu.2016.03.002 Taguchi C, 2015, NUTRIENTS, V7, P10269, DOI 10.3390/nu7125530 Tresserra-Rimbau A, 2013, NUTR METAB CARDIOVAS, V23, P953, DOI 10.1016/j.numecd.2012.10.008 Tsao R, 2010, NUTRIENTS, V2, P1231, DOI 10.3390/nu2121231 Webb M, 2009, AM J ROENTGENOL, V192, P909, DOI 10.2214/AJR.07.4016 Wilett W., 1998, NUTR EPIDEMIOLOGY, V2nd Yang F, 2017, FRONT PHARMACOL, V8, DOI 10.3389/fphar.2017.00929 Younossi ZM, 2016, HEPATOLOGY, V64, P73, DOI 10.1002/hep.28431 Zelber-Sagi S, 2018, J HEPATOL, V68, P1239, DOI 10.1016/j.jhep.2018.01.015 Zelber-Sagi S, 2016, THER ADV GASTROENTER, V9, P392, DOI 10.1177/1756283X16638830 Zelber-Sagil S, 2007, J HEPATOL, V47, P711, DOI 10.1016/j.jhep.2007.06.020 NR 50 TC 59 Z9 63 U1 1 U2 12 PU ELSEVIER PI AMSTERDAM PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS EI 2589-5559 J9 JHEP REP JI JHEP Rep. PD APR PY 2020 VL 2 IS 2 AR 100069 DI 10.1016/j.jhepr.2020.100069 PG 7 WC Gastroenterology & Hepatology WE Science Citation Index Expanded (SCI-EXPANDED) SC Gastroenterology & Hepatology GA RZ9QD UT WOS:000648932900003 PM 32195455 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Carrasco, I Olveira, A Lancharro, A Escosa, L Mellado, MJ Busca, C Montes, ML Díez, C Alcolea-Ruiz, S Navarro, ML Sainz, T AF Carrasco, Itziar Olveira, Antonio Lancharro, Angel Escosa, Luis Jose Mellado, Maria Busca, Carmen Luisa Montes, Maria Diez, Cristina Alcolea-Ruiz, Sonia Luisa Navarro, Maria Sainz, Talia TI Prevalence of nonalcoholic fatty liver disease using noninvasive techniques among children, adolescents, and youths living with HIV SO AIDS LA English DT Article DE adolescents; antiretroviral therapy; children; human immunodeficiency virus; nonalcoholic fatty liver disease; transient elastography; ultrasound; vertical transmission ID CONTROLLED ATTENUATION PARAMETER; HEPATIC STEATOSIS; MEDITERRANEAN DIET; INSULIN-RESISTANCE; ULTRASOUND; ELASTOGRAPHY; ASSOCIATION; INFECTION; DIAGNOSIS; FIBROSIS AB Objective: The prevalence of subclinical liver abnormalities is high among people with HIV, but data regarding perinatally HIV-infected children and adolescents (PHIV) are scarce. Noninvasive image techniques offer an opportunity to address nonalcoholic fatty liver disease (NAFLD) in a population in which the scores validated for adults have not been tested. Design: Prospective cross-sectional study including PHIV and uninfected controls. Methods: Noninvasive imaging techniques for the diagnosis of NAFLD and/or fibrosis were performed, and four scores to predict NAFLD were evaluated. Results: Seventy-six participants (59.2% women) with a median of 19 years old (interquartile range: 15.5-25.6) were included, 38 were PHIV and 38 were age and sex-matched controls. All HIV participants were on ART at the moment of inclusion, and 86.8% were virologically suppressed. A total of 11 PHIV and three controls were diagnosed with NAFLD (28.9% vs. 7.9%; P = 0.02) by noninvasive imaging techniques. The performance of scores based on clinical and analytical parameters was very poor. Although nonsignificant, overweight was more common among participants with NAFLD, who had a significantly higher BMI. Differences in HIV-related parameters between the groups were nonsignificant, except for the CD4(+)/CD8(+) T-cells ratio, decreased among PHIV diagnosed with NAFLD (P = 0.04). Conclusions: The prevalence of NAFLD was high (28.9%) among PHIV, and only partially explained by overweight and metabolic syndrome defining factors. The scores based on clinical and analytical parameters did not accurately identify participants at risk. Therefore, liver ultrasound assessment should be considered for the screening of NAFLD among PHIV in routine clinical practice. C1 [Carrasco, Itziar; Luisa Navarro, Maria] Hosp Gen Univ Gregorio Maranon, Serv Pediat, Madrid, Spain. [Carrasco, Itziar; Luisa Navarro, Maria] Inst Invest Sanitaria Gregorio Maranon, Madrid, Spain. [Carrasco, Itziar; Luisa Navarro, Maria] Univ Complutense Madrid, Madrid, Spain. [Carrasco, Itziar; Escosa, Luis; Jose Mellado, Maria; Busca, Carmen; Luisa Montes, Maria; Alcolea-Ruiz, Sonia; Luisa Navarro, Maria; Sainz, Talia] Inst Salud Carlos III, CIBER Enfermedades Infecciosas CIBERInfec, Madrid, Spain. [Olveira, Antonio] Hosp Univ La Paz, Gastroenterol Dept, Madrid, Spain. [Olveira, Antonio; Escosa, Luis; Jose Mellado, Maria; Busca, Carmen; Luisa Montes, Maria; Alcolea-Ruiz, Sonia; Sainz, Talia] Hosp Univ La Paz, La Paz Res Inst IdiPAZ, Madrid, Spain. [Lancharro, Angel] Hosp Gen Univ Gregorio Maranon, Serv Radiol, Madrid, Spain. [Lancharro, Angel] Inst Invest Sanitaria Gregorio Maran On, Madrid, Spain. [Escosa, Luis; Jose Mellado, Maria; Alcolea-Ruiz, Sonia; Sainz, Talia] Hosp Univ La Paz, Serv Pediat Enfermedades Infecciosas & Trop, Madrid, Spain. [Busca, Carmen; Luisa Montes, Maria] Hosp Univ La Paz, Infect Dis & Internal Med Dept, IV Unit, Madrid, Spain. [Diez, Cristina] Hosp Gen Univ Gregorio Maranon, Serv Microbiol Clin & Enfermedades Infecciosas, Madrid, Spain. C3 General University Gregorio Maranon Hospital; Complutense University of Madrid; Instituto de Salud Carlos III; Hospital Universitario La Paz; Hospital Universitario La Paz; General University Gregorio Maranon Hospital; Hospital Universitario La Paz; Hospital Universitario La Paz; General University Gregorio Maranon Hospital RP Carrasco, I (通讯作者)，Hosp Gen Univ Gregorio Maranon, Edificio Materno Infantil,C Doctor Esquerdo 46, Madrid 28007, Spain. EM itziiaarcg@gmail.com RI Escosa-Garcia, Luis/AFZ-2323-2022; Carrasco, Itziar/O-1724-2018; Sainz, Talia/AFL-6140-2022; Alcolea Ruiz, Sonia/T-8252-2017 OI LANCHARRO-ZAPATA, ANGEL M/0000-0001-9439-1951; Alcolea Ruiz, Sonia/0000-0003-1233-1723 FU Spanish Ministry of Science and Innovation - Instituto de Salud Carlos III -Fondos FEDER [PI17/01283]; Spanish Ministry of Science and Innovation - Instituto de Salud Carlos III - Fondos FEDER [JR16/00021, BA21/00022]; Instituto de Salud Carlos III-Spanish Ministry of Science and Innovation-Fondos FEDER [RD16/0025/0019] FX This work has been supported by the Spanish Ministry of Science and Innovation - Instituto de Salud Carlos III -Fondos FEDER (PI17/01283). T.S. has been funded by grants by the Spanish Ministry of Science and Innovation - Instituto de Salud Carlos III - Fondos FEDER (JR16/00021 and BA21/00022). The Spanish AIDS Research Network is supported by Instituto de Salud Carlos III-Spanish Ministry of Science and Innovation-Fondos FEDER (RD16/0025/0019). 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LIPIDS HEALTH DIS, V16, DOI 10.1186/s12944-017-0409-6 NR 70 TC 10 Z9 12 U1 0 U2 5 PU LIPPINCOTT WILLIAMS & WILKINS PI PHILADELPHIA PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA SN 0269-9370 EI 1473-5571 J9 AIDS JI Aids PD MAY 1 PY 2022 VL 36 IS 6 BP 805 EP 814 DI 10.1097/QAD.0000000000003170 PG 10 WC Immunology; Infectious Diseases; Virology WE Science Citation Index Expanded (SCI-EXPANDED) SC Immunology; Infectious Diseases; Virology GA 0Y1PF UT WOS:000790167000006 PM 35013082 DA 2026-02-02 ER PT J AU Abenavoli, L Greco, M Nazionale, I Peta, V Milic, N Accattato, F Foti, D Gulletta, E Luzza, F AF Abenavoli, Ludovico Greco, Marta Nazionale, Immacolata Peta, Valentina Milic, Natasa Accattato, Francesca Foti, Daniela Gulletta, Elio Luzza, Francesco TI Effects of Mediterranean diet supplemented with silybin-vitamin E-phospholipid complex in overweight patients with non-alcoholic fatty liver disease SO EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY LA English DT Article DE antioxidant; BMI; insulin resistance; liver steatosis; metabolism ID METABOLIC SYNDROME; MILK THISTLE; AMERICAN ASSOCIATION; INSULIN-RESISTANCE; PRACTICE GUIDELINE; EPIDEMIOLOGY; MANAGEMENT; SILYMARIN; DIAGNOSIS; STEATOSIS AB Background: Non-alcoholic fatty liver disease is the most common liver disease worldwide. Aim: The aim of this study is to compare the metabolic effects of the Mediterranean diet versus the diet associated with silybin, phosphatidylcholine and vitamin E complex in overweight patients with non-alcoholic fatty liver disease. Methods: Thirty Caucasian overweight patients were randomized into three groups of 10 (Groups A, B and C). A personalized Mediterranean diet was started in Group A and B patients. In association with the diet, Group B patients were given Realsil complex, daily, for 6 months. Group C patients refused any treatment. Results: We showed that the Mediterranean diet alone, or in association with the Realsil complex, led to the significant variation in BMI, waist circumference, total cholesterol and triglycerides. We also observed a statistically significant decrease in homeostasis model assessment technique in Group B patients. C1 [Abenavoli, Ludovico; Greco, Marta; Nazionale, Immacolata; Peta, Valentina; Accattato, Francesca; Foti, Daniela; Gulletta, Elio; Luzza, Francesco] Magna Graecia Univ Catanzaro, Dept Hlth Sci, I-88100 Catanzaro, Italy. [Milic, Natasa] Univ Novi Sad, Dept Pharm, Novi Sad 21000, Serbia. C3 Magna Graecia University of Catanzaro; University of Novi Sad RP Abenavoli, L (通讯作者)，Magna Graecia Univ Catanzaro, Dept Hlth Sci, Viale Europa Germaneto, I-88100 Catanzaro, Italy. 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Gastroenterol. Hepatol. PD APR PY 2015 VL 9 IS 4 BP 519 EP 527 DI 10.1586/17474124.2015.1004312 PG 9 WC Gastroenterology & Hepatology WE Science Citation Index Expanded (SCI-EXPANDED) SC Gastroenterology & Hepatology GA CD7IH UT WOS:000351263500012 PM 25617046 DA 2026-02-02 ER PT J AU Meir, AY Rinott, E Tsaban, G Zelicha, H Kaplan, A Rosen, P Shelef, I Youngster, I Shalev, A Blüher, M Ceglarek, U Stumvoll, M Tuohy, K Diotallevi, C Vrhovsek, U Hu, F Stampfer, M Shai, I AF Meir, Anat Yaskolka Rinott, Ehud Tsaban, Gal Zelicha, Hila Kaplan, Alon Rosen, Philip Shelef, Ilan Youngster, Ilan Shalev, Aryeh Bluher, Matthias Ceglarek, Uta Stumvoll, Michael Tuohy, Kieran Diotallevi, Camilla Vrhovsek, Urska Hu, Frank Stampfer, Meir Shai, Iris TI Effect of green-Mediterranean diet on intrahepatic fat: the DIRECT PLUS randomised controlled trial SO GUT LA English DT Article DE fatty liver; nutrition; magnetic resonance imaging; epidemiology ID MAGNETIC-RESONANCE-SPECTROSCOPY; LIVER-DISEASE; FOOD-FREQUENCY; FOLLOW-UP; POLYPHENOLS; STEATOSIS; MRI; BIOMARKERS; MICROBIOTA AB Objective To examine the effectiveness of green-Mediterranean (MED) diet, further restricted in red/processed meat, and enriched with green plants and polyphenols on non-alcoholic fatty liver disease (NAFLD), reflected by intrahepatic fat (IHF) loss. Design For the DIRECT-PLUS 18-month randomized clinical trial, we assigned 294 participants with abdominal obesity/dyslipidaemia into healthy dietary guidelines (HDG), MED and green-MED weight-loss diet groups, all accompanied by physical activity. Both isocaloric MED groups consumed 28 g/day walnuts (+440 mg/day polyphenols provided). The green-MED group further consumed green tea (3-4 cups/day) and Mankai (a Wolffia globosa aquatic plant strain; 100 g/day frozen cubes) green shake (+1240 mg/day total polyphenols provided). IHF% 18-month changes were quantified continuously by proton magnetic resonance spectroscopy (MRS). Results Participants (age=51 years; 88% men; body mass index=31.3 kg/m(2); median IHF%=6.6%; mean=10.2%; 62% with NAFLD) had 89.8% 18-month retention-rate, and 78% had eligible follow-up MRS. Overall, NAFLD prevalence declined to: 54.8% (HDG), 47.9% (MED) and 31.5% (green-MED), p=0.012 between groups. Despite similar moderate weight-loss in both MED groups, green-MED group achieved almost double IHF% loss (-38.9% proportionally), as compared with MED (-19.6% proportionally; p=0.035 weight loss adjusted) and HDG (-12.2% proportionally; p<0.001). After 18 months, both MED groups had significantly higher total plasma polyphenol levels versus HDG, with higher detection of Naringenin and 2-5-dihydroxybenzoic-acid in green-MED. Greater IHF% loss was independently associated with increased Mankai and walnuts intake, decreased red/processed meat consumption, improved serum folate and adipokines/lipids biomarkers, changes in microbiome composition (beta-diversity) and specific bacteria (p<0.05 for all). Conclusion The new suggested strategy of green-Mediterranean diet, amplified with green plant-based proteins/polyphenols as Mankai, green tea, and walnuts, and restricted in red/processed meat can double IHF loss than other healthy nutritional strategies and reduce NAFLD in half. C1 [Meir, Anat Yaskolka; Rinott, Ehud; Tsaban, Gal; Zelicha, Hila; Kaplan, Alon; Shai, Iris] Ben Gurion Univ Negev, Dept Publ Hlth, IL-84105 Beer Sheva, Southern, Israel. [Tsaban, Gal; Shalev, Aryeh] Soroka Med Ctr, Div Cardiol, Beer Sheva, Israel. [Rosen, Philip; Shelef, Ilan] Soroka Univ, Div Diagnost & Intervent Imaging, Med Ctr, Beer Sheva, Israel. [Youngster, Ilan] Shamir Med Ctr, Pediat Div, Beer Yaagov, Israel. [Youngster, Ilan] Shamir Med Ctr, Ctr Microbiome Res, Beer Yaagov, Israel. [Bluher, Matthias; Stumvoll, Michael] Univ Leipzig, Med Dept 3, Endocrinol Nephrol Rheumatol, Leipzig, Germany. [Ceglarek, Uta] Univ Leipzig, Inst Lab Med, Leipzig, Germany. [Tuohy, Kieran; Diotallevi, Camilla] Fdn Edmund Mach, Res & Innovat Ctr, Food Qual & Nutr, San Michelle Alladige, Italy. [Diotallevi, Camilla; Vrhovsek, Urska] Free Univ Bozen Bolzano, Fac Sci & Technol, Bolzano, Italy. [Hu, Frank; Stampfer, Meir; Shai, Iris] Harvard Univ, Dept Nutr, TH Chan Sch Publ Hlth, Boston, MA USA. [Hu, Frank; Stampfer, Meir] Brigham & Womens Hosp, Channing Div Network Med, Boston, MA USA. [Hu, Frank; Stampfer, Meir] Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA. C3 Ben-Gurion University of the Negev; Ben-Gurion University of the Negev; Soroka Medical Center; Ben-Gurion University of the Negev; Soroka Medical Center; Tel Aviv University; Shamir Medical Center (Assaf Harofeh); Tel Aviv University; Shamir Medical Center (Assaf Harofeh); Leipzig University; Leipzig University; Fondazione Edmund Mach; Free University of Bozen-Bolzano; Harvard University; Harvard T.H. Chan School of Public Health; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard University; Harvard T.H. Chan School of Public Health RP Shai, I (通讯作者)，Ben Gurion Univ Negev, Dept Publ Hlth, IL-84105 Beer Sheva, Southern, Israel. EM irish@bgu.ac.il RI Tuohy, Kieran/G-9142-2011; Stumvoll, Michael/ABE-1121-2021; Youngster, Ilan/AAZ-1225-2020; Shai, Iris/HJO-8533-2023; Meir, Anat/AAK-7469-2021; Rinott, Ehud/KRO-7063-2024; Ceglarek, Uta/GOE-5561-2022; Vrhovsek, Urska/E-9950-2011; Hu, Frank/C-1919-2013 OI Tuohy, Kieran/0000-0001-6882-7192; Stumvoll, Michael/0000-0001-6225-8240; Youngster, Ilan/0000-0001-5233-1213; Zelicha, Hila/0000-0001-6989-2332; Shai, Iris/0000-0001-9050-4605; FU Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) [209933838]; Israel Ministry of Health [87472511]; Israel Ministry of Science and Technology [3-13604]; California Walnuts Commission; Project 'Cabala_diet&health' - European Union [696295]; Kreitman Doctoral Fellowship at Ben-Gurion University of the Negev FX This work was funded by grants from the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation)-Project number 209933838-Collaborative Research CenterCentre SFB1052 'Obesity Mechanisms', to I Shai (SFB-1052/B11); Israel Ministry of Health grant 87472511 (to I Shai); Israel Ministry of Science and Technology grant 3-13604 (to I Shai); California Walnuts Commission (to I Shai) and the Project 'Cabala_diet&health' (http://www.cabalaproject.eu/) which received funding from the European Union's Horizon2020 research and innovation grant agreement No 696295-ERA--Net Cofund ERA--HDHL 'Biomarkers for Nutrition and Health implementing the JPI HDHL objectives' (https://www.healthydietforhealthylife.eu/) supported polyphenol analyses at FEM (to KT). 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It includes a wide spectrum of liver diseases ranging from simple fatty liver to steatohepatitis, which may progress to cirrhosis, liver cancer, and liver mortality. Common metabolic diseases, which are well established cardiovascular risk factors, have been associated to NAFLD and cardiovascular disease is the single most important cause of morbidity and mortality in this patient population. The pathogenesis of NAFLD appears multifactorial and many mechanisms have been proposed as possible causes of fatty liver infiltration. Management of fatty liver has become a major challenge to healthcare systems as the consequence of the increasing rates of obesity worldwide. First-line management focuses on lifestyle modifications. Moderate weight reduction either by dietary restriction or by increased habitual physical activity is safe and highly recommended. Several therapeutic interventions have been proposed. These include insulin sensitizer agents, lipid lowering drugs, antioxidants such as vitamin E and supplementation of vitamin D-3. However, therapeutic strategies have been largely empirical so far, and experimental trials have mostly been carried out in uncontrolled settings with small sample sizes. Metabolic conditions such as diabetes mellitus, obesity, hypertension and hyperlipidemia, should be strongly considered and a multidisciplinary approach should be personalized for individual patients. Treatment of co-morbidities should be regarded as of paramount importance in the management of these patients. The purpose of this review is to examine different approaches for the clinical management of non-alcoholic fatty liver disease. (C) 2014 Baishideng Publishing Group Inc. All rights reserved. C1 [Del Ben, Maria; Polimeni, Licia; Baratta, Francesco; Pastori, Daniele; Loffredo, Lorenzo] Dept Internal Med & Med Special, I-00161 Rome, Italy. 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CA, UNITED STATES SN 1007-9327 EI 2219-2840 J9 WORLD J GASTROENTERO JI World J. Gastroenterol. PD JUL 14 PY 2014 VL 20 IS 26 BP 8341 EP 8350 DI 10.3748/wjg.v20.i26.8341 PG 10 WC Gastroenterology & Hepatology WE Science Citation Index Expanded (SCI-EXPANDED) SC Gastroenterology & Hepatology GA AL8LF UT WOS:000339389500002 PM 25024593 OA Green Submitted DA 2026-02-02 ER PT J AU Quetglas-Llabrés, MM Monserrat-Mesquida, M Bouzas, C García, S Argelich, E Casares, M Ugarriza, L Llompart, I Tur, JA Sureda, A AF Quetglas-Llabres, Maria Magdalena Monserrat-Mesquida, Margalida Bouzas, Cristina Garcia, Silvia Argelich, Emma Casares, Miguel Ugarriza, Lucia Llompart, Isabel Tur, Josep A. Sureda, Antoni TI Impact of Adherence to the Mediterranean Diet on Antioxidant Status and Metabolic Parameters in NAFLD Patients: A 24-Month Lifestyle Intervention Study SO ANTIOXIDANTS LA English DT Article DE non-alcoholic fatty liver disease; intrahepatic fat contents; lifestyle; erythrocytes; antioxidant score ID CARDIOVASCULAR RISK-FACTORS; LIVER-DISEASE PATIENTS; OXIDATIVE STRESS; PATHOGENESIS; GLUTATHIONE; BLOOD; FAT AB Background: The Mediterranean Diet (MedDiet) is recognized as a healthy dietary pattern. Non-alcoholic fatty liver disease (NAFLD) is characterized by the excessive accumulation of fat in the liver. Objectives: To assess the antioxidant status in erythrocytes, plasma, and peripheral blood mononuclear cells (PBMCs) of NAFLD patients following a 24-month lifestyle intervention based on the MedDiet. Adult patients (n = 40; aged 40-60 years) diagnosed with NAFLD by magnetic resonance imaging were divided into two groups based on their adherence to the MedDiet. Consumption was assessed using a validated 143-item semiquantitative Food Frequency Questionnaire. Anthropometrics, biochemistry parameters, intrahepatic fat contents (IFC), antioxidants, and inflammatory biomarkers were measured in plasma and erythrocytes before and after the intervention. Results: After the intervention, body mass index (BMI) and plasma levels of total cholesterol, low-density lipoprotein cholesterol (LDL-chol), triglycerides, malondialdehyde (MDA), and cytokeratin-18 (CK18) decreased, and high-density lipoprotein cholesterol (HDL-chol) increased. Participants with high adherence to MedDiet showed lower IFC, hepatic enzyme (AST, ALT, and GGT), glycemia, oxidase LDL (oxLDL) plasma levels, and erythrocyte MDA levels. Higher antioxidant activity (erythrocyte catalase-CAT, superoxide dismutase-SOD, glutathione peroxidase-GPx, glutathione reductase-GRd, and total glutathione-GSH as well as PBMCs-CAT gene expression) was observed in these patients, along with a reduction of PBMCs reactive oxygen species production and Toll-like receptor 4 (TLR4) expression. Inverse associations were observed between adherence to the MedDiet and BMI, glycemia, AST, IFC, and CK18 plasma levels and oxLDL, CAT, SOD, and GRd activities in erythrocytes. A significant linear regression was observed between adherence to the MedDiet and antioxidant score. Conclusions: Adherence to the MedDiet is associated with improved plasma and PBMC antioxidant and inflammatory biomarker profiles and high antioxidant defences in erythrocytes. C1 [Quetglas-Llabres, Maria Magdalena; Monserrat-Mesquida, Margalida; Bouzas, Cristina; Garcia, Silvia; Argelich, Emma; Ugarriza, Lucia; Llompart, Isabel; Tur, Josep A.; Sureda, Antoni] Univ Balear Isl IUNICS, Res Grp Community Nutr & Oxidat Stress, Palma De Mallorca 07122, Spain. [Quetglas-Llabres, Maria Magdalena; Monserrat-Mesquida, Margalida; Bouzas, Cristina; Garcia, Silvia; Argelich, Emma; Ugarriza, Lucia; Llompart, Isabel; Tur, Josep A.; Sureda, Antoni] Inst Salud Carlos III, CIBEROBN Physiopathol Obes & Nutr, Madrid 28029, Spain. [Quetglas-Llabres, Maria Magdalena; Monserrat-Mesquida, Margalida; Bouzas, Cristina; Garcia, Silvia; Argelich, Emma; Ugarriza, Lucia; Llompart, Isabel; Tur, Josep A.; Sureda, Antoni] Hlth Res Inst Balear Isl IdISBa, Palma De Mallorca 07120, Spain. [Casares, Miguel] Red Asistencial Juaneda, Radiodiag Serv, Palma De Mallorca 07011, Spain. [Ugarriza, Lucia] IBSalut, CS Camp Redo, Palma De Mallorca 07010, Spain. [Llompart, Isabel] Univ Hosp Son Espases, Clin Anal Serv, Palma De Mallorca 07198, Spain. C3 Instituto de Salud Carlos III; CIBER - Centro de Investigacion Biomedica en Red; CIBEROBN; Institut Investigacio Sanitaria Illes Balears (IdISBa); Hospital Universitari Son Espases RP Tur, JA (通讯作者)，Univ Balear Isl IUNICS, Res Grp Community Nutr & Oxidat Stress, Palma De Mallorca 07122, Spain.; Tur, JA (通讯作者)，Inst Salud Carlos III, CIBEROBN Physiopathol Obes & Nutr, Madrid 28029, Spain.; Tur, JA (通讯作者)，Hlth Res Inst Balear Isl IdISBa, Palma De Mallorca 07120, Spain. EM margalida.monserrat@uib.es; isabel.llompart@ssib.es; pep.tur@uib.es; antoni.sureda@uib.es RI Sureda, Antoni/N-9588-2019; Bouzas, Cristina/AAE-2069-2019; Monserrat Mesquida, Margalida/AAB-4773-2019; Tur, Josep/AAE-5748-2020; Quetglas Llabrés, Maria Magdalena/AAA-4412-2019 OI Bouzas Velasco, Cristina/0000-0002-1407-8461; Monserrat Mesquida, Margalida/0000-0002-8856-135X; Tur, Josep/0000-0002-6940-0761; García, Silvia/0000-0003-3534-1588; Quetglas Llabrés, Maria Magdalena/0000-0003-4155-7780; , Antoni/0000-0001-8656-6838 FU Fundaci La Marat TV3 (Spain); CIBEROBN is an initiative of the Instituto de Salud Carlos III, Spain FX The authors especially thank the participants for their enthusiastic collaboration and the personnel for outstanding support and exceptional effort. The authors thank Octavio Barbero from Red Asistencial Juaneda, Palma de Mallorca, Spain, for technical assistance. CIBEROBN is an initiative of the Instituto de Salud Carlos III, Spain. 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Arnal, Carmen Bidooki, Seyed Hesamoddin Sanchez-Marco, Javier Lasheras, Roberto Surra, Joaquin C. Rodriguez-Yoldi, Maria Jesus Martinez-Beamonte, Roberto Osada, Jesus TI Differentially Expressed Genes in Response to a Squalene-Supplemented Diet Are Accurate Discriminants of Porcine Non-Alcoholic Steatohepatitis SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES LA English DT Article DE squalene; virgin olive oil; pigs; murine AML12 cell line; human HEPG2 cell line; transcriptome; hepatic; RNA sequencing; AFP; PPP1R1B; ENPEP ID FATTY LIVER-DISEASE; ACTIVATED RECEPTOR-ALPHA; INSULIN-SECRETION; OXIDATIVE STRESS; LIPID-METABOLISM; PROLIFERATION; PROTEOMICS; TMEM45B; EPIDEMIOLOGY; HEPATOCYTES AB Squalene is the major unsaponifiable component of virgin olive oil, the fat source of the Mediterranean diet. To evaluate its effect on the hepatic transcriptome, RNA sequencing was carried out in two groups of male Large White x Landrace pigs developing nonalcoholic steatohepatitis by feeding them a high fat/cholesterol/fructose and methionine and choline-deficient steatotic diet or the same diet with 0.5% squalene. Hepatic lipids, squalene content, steatosis, activity (ballooning + inflammation), and SAF (steatosis + activity + fibrosis) scores were analyzed. Pigs receiving the latter diet showed hepatic squalene accumulation and twelve significantly differentially expressed hepatic genes (log2 fold change < 1.5 or <1.5) correlating in a gene network. These pigs also had lower hepatic triglycerides and lipid droplet areas and higher cellular ballooning. Glutamyl aminopeptidase (ENPEP) was correlated with triglyceride content, while alpha-fetoprotein (AFP), neutralized E3 ubiquitin protein ligase 3 (NEURL3), 20-50-oligoadenylate synthase-like protein (OASL), and protein phosphatase 1 regulatory inhibitor subunit 1B (PPP1R1B) were correlated with activity reflecting inflammation and ballooning, and NEURL3 with the SAF score. AFP, ENPEP, and PPP1R1B exhibited a remarkably strong discriminant power compared to those pathological parameters in both experimental groups. Moreover, the expression of PPP1R1B, TMEM45B, AFP, and ENPEP followed the same pattern in vitro using human hepatoma (HEPG2) and mouse liver 12 (AML12) cell lines incubated with squalene, indicating a direct effect of squalene on these expressions. These findings suggest that squalene accumulated in the liver is able to modulate gene expression changes that may influence the progression of non-alcoholic steatohepatitis. C1 [Abuobeid, Roubi; Herrera-Marcos, Luis V.; Bidooki, Seyed Hesamoddin; Sanchez-Marco, Javier; Martinez-Beamonte, Roberto; Osada, Jesus] Univ Zaragoza, Fac Vet, Dept Bioquim & Biol Mol & Celular, Inst Invest Sanitaria Aragon, E-50013 Zaragoza, Spain. [Herrera-Marcos, Luis V.; Arnal, Carmen; Bidooki, Seyed Hesamoddin; Surra, Joaquin C.; Rodriguez-Yoldi, Maria Jesus; Martinez-Beamonte, Roberto; Osada, Jesus] Univ Zaragoza, Inst Agroalimentario Aragon, CITA, E-50013 Zaragoza, Spain. [Arnal, Carmen] Univ Zaragoza, Fac Vet, Dept Patol Anim, Inst Invest Sanitaria Aragon, E-50013 Zaragoza, Spain. [Arnal, Carmen; Surra, Joaquin C.; Rodriguez-Yoldi, Maria Jesus; Martinez-Beamonte, Roberto; Osada, Jesus] Inst Salud Carlos III, CIBER Fisiopatol Obes & Nutr, E-28029 Madrid, Spain. [Lasheras, Roberto] Serv Segur Agroalimentaria Direcc Gen Alimentac &, Lab Agroambiental, E-50071 Zaragoza, Spain. [Surra, Joaquin C.] Univ Zaragoza, Dept Prod Anim & Ciencia Alimentos, Escuela Politecn Super Huesca, Inst Invest Sanitaria Aragon, E-22071 Huesca, Spain. [Rodriguez-Yoldi, Maria Jesus] Univ Zaragoza, Fac Vet, Dept Farmacol Fisiol Med Legal & Forense, Inst Invest Sanitaria Aragon, E-50013 Zaragoza, Spain. C3 University of Zaragoza; University of Zaragoza; University of Zaragoza; CIBER - Centro de Investigacion Biomedica en Red; CIBEROBN; Instituto de Salud Carlos III; University of Zaragoza; University of Zaragoza RP Osada, J (通讯作者)，Univ Zaragoza, Fac Vet, Dept Bioquim & Biol Mol & Celular, Inst Invest Sanitaria Aragon, E-50013 Zaragoza, Spain.; Osada, J (通讯作者)，Univ Zaragoza, Inst Agroalimentario Aragon, CITA, E-50013 Zaragoza, Spain.; Osada, J (通讯作者)，Inst Salud Carlos III, CIBER Fisiopatol Obes & Nutr, E-28029 Madrid, Spain. EM josada@unizar.es RI ; Surra, Joaquín/G-1128-2014; Marcos, Luis/AAQ-3645-2020; Martínez Beamonte, Roberto/E-4981-2016; bidooki, seyed hesamoddin/IZE-5229-2023 OI Sánchez-Marco, Javier/0000-0002-9023-741X; AbuObeid, Roubi/0009-0006-1087-8150; Rodríguez Yoldi, María Jesús/0000-0002-3595-7668; Martínez Beamonte, Roberto/0000-0002-8100-5596; bidooki, seyed hesamoddin/0000-0002-5612-5000 FU Ministerio de Ciencia e Innovacion-Fondo Europeo de Desarrollo Regional (MCIN/AEI) [PID2019-104915RB-I00, PID2022-104915RB-I00]; Fondo Social Europeo-Gobierno de Aragon [B16_23R]; CIBER de Fisiopatologia de la Obesidad y Nutricion (CIBEROBN) [CB06/03/1012]; Universities of Zaragoza; Fundacion Cuenca Villoro fellowship; Fondo Social Europeo-Gobierno de Aragon contract FX This research was funded by the Ministerio de Ciencia e Innovacion-Fondo Europeo de Desarrollo Regional (MCIN/AEI/10.13039/501100011033, PID2019-104915RB-I00 and PID2022-104915RB-I00) and Fondo Social Europeo-Gobierno de Aragon (B16_23R). CIBER de Fisiopatologia de la Obesidad y Nutricion (CIBEROBN, CB06/03/1012) is an initiative of ISCIII. S.H.B. was received a joint fellowship from the Universities of Zaragoza and Pau, J.S.-M. was the recipient of a Fundacion Cuenca Villoro fellowship and L.V.H.M. was recipient of a Fondo Social Europeo-Gobierno de Aragon contract. 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PD AUG PY 2023 VL 24 IS 16 AR 12552 DI 10.3390/ijms241612552 PG 20 WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary WE Science Citation Index Expanded (SCI-EXPANDED) SC Biochemistry & Molecular Biology; Chemistry GA Q5BT6 UT WOS:001057678300001 PM 37628732 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Harari, A Frenkel, AL Barshack, I Sagee, A Cohen, H Kamari, Y Harats, D Kfir, MK Shaish, A AF Harari, Ayelet Frenkel, Alicia Leikin Barshack, Iris Sagee, Aviv Cohen, Hofit Kamari, Yehuda Harats, Dror Kfir, Michal Kandel Shaish, Aviv TI Addition of fish oil to atherogenic high fat diet inhibited atherogenesis while olive oil did not, in LDL receptor KO mice SO NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES LA English DT Article DE Atherosclerotic lesion; Nonalcoholic fatty liver disease; LDL receptor knockout mice; Fish oil; Olive oil; High fat diet ID E-DEFICIENT MICE; LIVER-DISEASE; VIRGIN-OLIVE; HEPATIC STEATOSIS; ATHEROSCLEROSIS; ACIDS; DECREASES; DYSLIPIDEMIA; INFLAMMATION; PROTECTION AB Background and aims: Mediterranean diet has been associated with decreased cardiovascular morbidity and mortality. Both fish and olive oil are key components of this diet. Therefore, we compared their effects on nonalcoholic fatty liver disease (NAFLD) and atherogenesis in a mouse model, fed a high fat diet. Methods and results: Forty nine, female LDL receptor knockout (LDLR KO) mice were allocated into 3 groups and fed an atherogenic high fat (HF) diet for 9 weeks. The HF group was fed a high fat diet alone. A HF + OO group was fed a HF diet with added olive oil (60 ml/kg feed), and the third group (HF + FO) was fed a HF diet with added fish oil (60 ml/kg feed). Both additions of fish and olive oil, significantly decreased plasma cholesterol elevation compared to HF diet. Nevertheless, only fish oil addition reduced significantly atherosclerotic lesion area by 51% compared to HF group. Liver levels of eicosapentenoic (EPA) and docosahexaenoic (DHA) acids were several folds higher in HF + FO group than in HF and HF + OO groups. Liver levels of oleic acid were higher in HF + OO compared to the other groups. Moreover, Fish oil addition significantly decreased NAFLD scores related to steatosis and inflammation and lowered the expression of the inflammatory genes interleukin 6 (IL6) and monocyte chemoattractant protein 1 (MCP1). Conclusion: These results suggest that fish oil addition on top of an atherogenic, HF diet, is beneficial, while olive oil is not, in its effect on plaque formation and NAFLD in LDLR KO mice. (C) 2019 The Italian Society of Diabetology, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition, and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved. C1 [Harari, Ayelet; Frenkel, Alicia Leikin; Sagee, Aviv; Cohen, Hofit; Kamari, Yehuda; Harats, Dror; Kfir, Michal Kandel; Shaish, Aviv] Sheba Med Ctr, Bert W Strassburger Lipid Ctr, IL-5265601 Ramat Gan, Israel. [Frenkel, Alicia Leikin; Barshack, Iris; Cohen, Hofit; Kamari, Yehuda; Harats, Dror] Tel Aviv Univ, Sackler Fac Med, Tel Aviv, Israel. [Barshack, Iris] Sheba Med Ctr, Inst Pathol, IL-5265601 Ramat Gan, Israel. [Shaish, Aviv] Achva Acad Coll, Arugot, Israel. C3 Tel Aviv University; Chaim Sheba Medical Center; Tel Aviv University; Sackler Faculty of Medicine; Chaim Sheba Medical Center; Tel Aviv University; Achva Academic College RP Harari, A (通讯作者)，Sheba Med Ctr, Bert W Strassburger Lipid Ctr, IL-5265601 Tel Hashomer, Israel. 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PD APR 12 PY 2020 VL 30 IS 4 BP 709 EP 716 DI 10.1016/j.numecd.2019.12.007 PG 8 WC Cardiac & Cardiovascular Systems; Endocrinology & Metabolism; Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Cardiovascular System & Cardiology; Endocrinology & Metabolism; Nutrition & Dietetics GA KZ9DM UT WOS:000523557700019 PM 32007335 DA 2026-02-02 ER PT J AU Liu, ZN Huang, HK Zeng, Y Chen, YS Xu, CF AF Liu, Zhening Huang, Hangkai Zeng, Yan Chen, Yishu Xu, Chengfu TI Association between ultra-processed foods consumption and risk of non-alcoholic fatty liver disease: a population-based analysis of NHANES 2011-2018 SO BRITISH JOURNAL OF NUTRITION LA English DT Article DE Ultra-processed foods; Fatty liver disease; Insulin resistance; Dietary pattern ID GLYCATION END-PRODUCTS; MEDITERRANEAN DIET; UNITED-STATES; FRUCTOSE; PATTERN AB An increasing number of studies have evaluated the association between ultra-processed foods (UPF) consumption and metabolic disorders. However, the association between UPF intake and non-alcoholic fatty liver disease (NAFLD) remains unclear. In this study, we analysed data from 6545 participants who were recruited in National Health and Nutrition Examination Surveys 2011-2018. UPF were defined in light of the NOVA food classification system and divided into quartiles based on its proportion of total weight intake. Complex logistic regression models were used to assess the association between UPF and NAFLD. Mediation analyses were conducted to reveal underlying mediators. We found that NAFLD patients consumed more UPF than controls (925 center dot 92 +/- 18 center dot 08 v. 812 center dot 70 +/- 14 center dot 32 g/d, P < 0 center dot 001). Dietary intake of UPF (% weight) was negatively related to the Healthy Eating Index-2015 score (Spearman r = -0 center dot 32, P < 0 center dot 001). In the multivariable model, the highest quartile compared with the lowest, the OR (95 % CI) were 1 center dot 83 (1 center dot 33, 2 center dot 53) for NAFLD (OR per 10 % increment: 1 center dot 15; 95 % CI: 1 center dot 09, 1 center dot 22; P for trend < 0 center dot 001) and 1 center dot 52 (1 center dot 12, 2 center dot 07) for insulin resistance (OR per 10 % increment: 1 center dot 11; 95 % CI: 1 center dot 05, 1 center dot 18; P for trend = 0 center dot 002). Mediation analyses revealed that poor diet quality, high saturated fat and refined grain intake partly mediated the association between UPF and NAFLD. In conclusion, high UPF intake was associated with an increased risk of NAFLD in US adults. Further prospective studies are needed to verify these findings. C1 [Liu, Zhening; Huang, Hangkai; Zeng, Yan; Chen, Yishu; Xu, Chengfu] Zhejiang Univ, Affiliated Hosp 1, Dept Gastroenterol, Sch Med, 79 Qingchun Rd, Hangzhou 310003, Peoples R China. C3 Zhejiang University RP Xu, CF (通讯作者)，Zhejiang Univ, Affiliated Hosp 1, Dept Gastroenterol, Sch Med, 79 Qingchun Rd, Hangzhou 310003, Peoples R China. EM xiaofu@zju.edu.cn RI Xu, Chengfu/HTL-9950-2023 OI Xu, Chengfu/0000-0002-6172-1253 FU National Key Research and Development Program of China; National Natural Science Foundation of China [2018YFA0109800]; Key Research and Development Program of Zhejiang Province [82070585]; [2020C03033] FX Acknowledgements We thank members of the National Center for Health Statistics of the Centers for Disease Control and Prevention and the participants who enrolled in the National Health and Nutrition Examination Survey. This work was supported by the National Key Research and Development Program of China (2018YFA0109800), National Natural Science Foundation of China (82070585) and Key Research and Development Program of Zhejiang Province (2020C03033). Z. L.: conceptualisation, formal analysis, software, writing-original draft. H. H.: writing-original draft. Y. Z.: software. Y. C.: data curation. C. X.: project administration, funding acquisition, conceptualisation, supervision. The authors declare no conflicts of interest. 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J. Nutr. PD SEP 28 PY 2023 VL 130 IS 6 BP 996 EP 1004 AR PII S0007114522003956 DI 10.1017/S0007114522003956 PG 9 WC Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Nutrition & Dietetics GA FP0W1 UT WOS:001146936800007 PM 36522692 DA 2026-02-02 ER PT J AU Lee, HJ Yeon, JE Ko, EJ Yoon, EL Suh, SJ Kang, K Kim, HR Kang, SH Yoo, YJ Je, J Lee, BJ Kim, JH Seo, YS Yim, HJ Byun, KS AF Lee, Hyun Jung Yeon, Jong Eun Ko, Eun Jung Yoon, Eileen L. Suh, Sang Jun Kang, Keunhee Kim, Hae Rim Kang, Seoung Hee Yoo, Yang Jae Je, Jihye Lee, Beom Jae Kim, Ji Hoon Seo, Yeon Seok Yim, Hyung Joon Byun, Kwan Soo TI Peroxisome proliferator-activated receptor-delta agonist ameliorated inflammasome activation in nonalcoholic fatty liver disease SO WORLD JOURNAL OF GASTROENTEROLOGY LA English DT Article DE Nonalcoholic fatty liver disease; Nonalcoholic steatohepatitis; Inflammasome; Nucleotide-binding and oligomerization domain-like receptor; Peroxisome proliferator-activated receptors delta ID NLRP3 INFLAMMASOME; INSULIN SENSITIVITY; OVERWEIGHT PATIENTS; GLUCOSE-METABOLISM; MEDITERRANEAN DIET; STEATOHEPATITIS; ACID; OBESITY; EXPRESSION; MICE AB AIM: To evaluate the inflammasome activation and the effect of peroxisome proliferator-activated receptors (PPAR)-delta agonist treatment in nonalcoholic fatty liver disease (NAFLD) models. METHODS: Male C57BL/6J mice were classified according to control or high fat diet (HFD) with or without PPAR-delta agonist (GW) over period of 12 wk [control, HFD, HFD + lipopolysaccharide (LPS), HFD + LPS + GW group]. HepG2 cells were exposed to palmitic acid (PA) and/or LPS in the absence or presence of GW. RESULTS: HFD caused glucose intolerance and hepatic steatosis. In mice fed an HFD with LPS, caspase-1 and interleukin (IL)-1 beta in the liver were significantly increased. Treatment with GW ameliorated the steatosis and inhibited overexpression of pro-inflammatory cytokines. In HepG2 cells, PA and LPS treatment markedly increased mRNA of several nucleotide-binding and oligomerization domain-like receptor family members (NLRP3, NLRP6, and NLRP10), caspase-1 and IL-1 beta. PA and LPS also exaggerated reactive oxygen species production. All of the above effects of PA and LPS were reduced by GW. GW also enhanced the phosphorylation of AMPK-alpha. CONCLUSION: PPAR-delta agonist reduces fatty acid-induced inflammation and steatosis by suppressing inflammasome activation. Targeting the inflammasome by the PPAR-delta agonist may have therapeutic implication for NAFLD. Key words: Nonalcoholic fatty liver disease; Nonalcoholic steatohepatitis; Inflammasome; Nucleotide-binding and oligomerization domain-like receptor; Peroxisome proliferator-activated receptors delta C1 [Lee, Hyun Jung; Yeon, Jong Eun; Ko, Eun Jung; Yoon, Eileen L.; Suh, Sang Jun; Kang, Keunhee; Kim, Hae Rim; Kang, Seoung Hee; Yoo, Yang Jae; Je, Jihye; Lee, Beom Jae; Kim, Ji Hoon; Seo, Yeon Seok; Yim, Hyung Joon; Byun, Kwan Soo] Korea Univ, Coll Med, Dept Internal Med, Seoul 152703, South Korea. C3 Korea University; Korea University Medicine (KU Medicine) RP Yeon, JE (通讯作者)，Korea Univ, Coll Med, Dept Internal Med, 97 Guro Dong Gil,Guro Dong, Seoul 152703, South Korea. 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Gastroenterol. PD DEC 7 PY 2015 VL 21 IS 45 BP 12787 EP 12799 DI 10.3748/wjg.v21.i45.12787 PG 13 WC Gastroenterology & Hepatology WE Science Citation Index Expanded (SCI-EXPANDED) SC Gastroenterology & Hepatology GA CX8PR UT WOS:000365966600006 PM 26668503 OA Green Submitted DA 2026-02-02 ER PT J AU Chu, NHS Chow, E Chan, JCN AF Chu, Natural H. S. Chow, Elaine Chan, Juliana C. N. TI The Therapeutic Potential of the Specific Intestinal Microbiome (SIM) Diet on Metabolic Diseases SO BIOLOGY-BASEL LA English DT Review DE prebiotics; metabolic diseases; fermentable carbohydrates; specific intestinal microbiome; diabetes; NAFLD; obesity; metabolic cardiovascular diseases ID BUTYRATE-PRODUCING BACTERIA; POSTPRANDIAL BLOOD-GLUCOSE; TYPE-2 DIABETES-MELLITUS; INULIN-TYPE FRUCTANS; CHAIN FATTY-ACIDS; GUT-MICROBIOTA; PLASMA TRIACYLGLYCEROL; FRUCTOSE CONSUMPTION; INSULIN SENSITIVITY; LIPID-METABOLISM AB Simple Summary Prebiotics, essential for humans and our gut microbiome, maintain the ecosystem's homeostasis in a mutual relationship with the host and microbiome. As a gut microbiome modulator, poorly absorbed or indigestible carbohydrates interact with the gut microbiome, and its metabolites promote immune health. However, there is limited discussion of a habitual diet in metabolic diseases. Exploring the intricate crosstalk between dietary prebiotics and the specific intestinal microbiome (SIM) is intriguing to gain deeper insights into their therapeutic implications.Abstract Exploring the intricate crosstalk between dietary prebiotics and the specific intestinal microbiome (SIM) is intriguing in explaining the mechanisms of current successful dietary interventions, including the Mediterranean diet and high-fiber diet. This knowledge forms a robust basis for developing a new natural food therapy. The SIM diet can be measured and evaluated to establish a reliable basis for the management of metabolic diseases, such as diabetes, metabolic (dysfunction)-associated fatty liver disease (MAFLD), obesity, and metabolic cardiovascular disease. This review aims to delve into the existing body of research to shed light on the promising developments of possible dietary prebiotics in this field and explore the implications for clinical practice. The exciting part is the crosstalk of diet, microbiota, and gut-organ interactions facilitated by producing short-chain fatty acids, bile acids, and subsequent metabolite production. These metabolic-related microorganisms include Butyricicoccus, Akkermansia, and Phascolarctobacterium. The SIM diet, rather than supplementation, holds the promise of significant health consequences via the prolonged reaction with the gut microbiome. Most importantly, the literature consistently reports no adverse effects, providing a strong foundation for the safety of this dietary therapy. C1 [Chu, Natural H. S.; Chow, Elaine; Chan, Juliana C. N.] Chinese Univ Hong Kong, Prince Wales Hosp, Dept Med & Therapeut, Hong Kong, Peoples R China. [Chan, Juliana C. N.] Chinese Univ Hong Kong, Prince Wales Hosp, Hong Kong Inst Diabet & Obes, Hong Kong, Peoples R China. [Chan, Juliana C. N.] Chinese Univ Hong Kong, Prince Wales Hosp, Li Ka Shing Inst Hlth Sci, Hong Kong, Peoples R China. 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165 TC 5 Z9 5 U1 1 U2 10 PU MDPI PI BASEL PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND EI 2079-7737 J9 BIOLOGY-BASEL JI Biology-Basel PD JUL PY 2024 VL 13 IS 7 AR 498 DI 10.3390/biology13070498 PG 21 WC Biology WE Science Citation Index Expanded (SCI-EXPANDED) SC Life Sciences & Biomedicine - Other Topics GA ZP6B3 UT WOS:001276528000001 PM 39056692 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Vilar, EG Rojo, SS Oliva, SL Martinez, S Lora, AT Martin, IS AF Vilar, Elena Garicano Rojo, Sara Sanz Oliva, Sara Lopez Martinez, Silvia Lora, Ana Terren Martin, Ismael San Mauro TI Effect of MetioNac® in patients with metabolic syndrome who are at risk of metabolic dysfunction associated fatty liver disease: a randomized controlled trial SO NUTRICION HOSPITALARIA LA English DT Article DE Metabolic syndrome; Metabolic associated fatty liver disease; S-adenosyl-L-methionine; N-acetylcysteine; Thioctic acid; Vitamin B6 ID SCREENING TOOLS; OLDER-ADULTS; SHORT-FORM; CLINICAL-OUTCOMES; MALNUTRITION; IDENTIFICATION; VALIDATION; COMMUNITY; DISCHARGE; NUTRITION AB Introduction: metabolic syndrome comprises a combination of diabetes, high blood pressure, and obesity, and metabolic associated fatty liver disease (MAFLD) is associated with it.Objective: to evaluate the effect of supplementation with S-adenosyl-L-methionine + N-acetylcysteine + thioctic acid + vitamin B6 (MetioNac (R)) for 3 months on lipidic and biochemical parameters in subjects with metabolic syndrome and at risk of MAFLD. The reduction in body weight and the oxidative stress markers malondialdehyde (MDA) and superoxide dismutase (SOD) were also evaluated.Methods: patients with metabolic syndrome, at risk of MAFLD (FIB-4 < 1.30), and with an indication for weight reduction were recruited (n = 15). Control group followed a semipersonalized Mediterranean diet (MD) for weight reduction, according to the recommendations of the Spanish Society for the Study of Obesity (SEEDO). Experimental group, in addition to the MD, took three capsules of MetioNac (R) supplement per day.Results: compared with the control group, subjects taking MetioNac (R) showed significant (p < 0.05) reductions in the levels of TG and VLDL-c, as well as in total cholesterol, LDL-c, and glucose levels. They also showed increased levels of HDL-c. Levels of AST and ALT decreased after the intervention with MetioNac (R), but this decrease did not reach statistical significance. Weight loss was observed in both groups.Conclusion: supplementation with MetioNac (R) may be protective against hyperlipidemia, insulin resistance, and overweight among metabolic syndrome patients. Further studies on this issue are needed in a larger population. C1 [Vilar, Elena Garicano; Rojo, Sara Sanz; Oliva, Sara Lopez; Lora, Ana Terren; Martin, Ismael San Mauro] Res Ctr Nutr & Hlth, CINUSA Grp, Paseo Habana 43, Madrid 28036, Spain. [Martinez, Silvia] Margan Biotech, Ajalvir, Madrid, Spain. RP Martin, IS (通讯作者)，Res Ctr Nutr & Hlth, CINUSA Grp, Paseo Habana 43, Madrid 28036, Spain. EM info@grupocinusa.es RI ; González-Martínez, Silvia/ABA-6150-2021 OI Sanz Rojo, Sara/0000-0003-4737-5857; CR Administracao Central do Sistema de Sat:de (ACSS). 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PD JUL-AUG PY 2023 VL 40 IS 4 BP 755 EP 762 DI 10.20960/nh.04635 PG 8 WC Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Nutrition & Dietetics GA X6SO7 UT WOS:001099729300011 PM 37409712 OA gold DA 2026-02-02 ER PT J AU Reginato, E Pippi, R Aiello, C Tomaro, ES Ranucci, C Buratta, L Bini, V Marchesini, G De Feo, P Fanelli, C AF Reginato, Elisa Pippi, Roberto Aiello, Cristina Tomaro, Emilia Sbroma Ranucci, Claudia Buratta, Livia Bini, Vittorio Marchesini, Giulio De Feo, Pierpaolo Fanelli, Carmine TI Effect of Short Term Intensive Lifestyle Intervention on Hepatic Steatosis Indexes in Adults with Obesity and/or Type 2 Diabetes SO JOURNAL OF CLINICAL MEDICINE LA English DT Article DE Non-alcoholic fatty liver disease; obesity; type 2 diabetes mellitus; lifestyle; exercise ID FATTY LIVER-DISEASE; CARDIOVASCULAR-DISEASE; ASSOCIATION AB Background: Non-alcoholic fatty liver disease (NAFLD) has an estimated prevalence of 20-30% in the general population and even higher in individuals with metabolic risk factors. The aim of this study was to evaluate the effect of a lifestyle intervention program on surrogate markers of hepatic steatosis in obesity and/or type 2 diabetes patients, enrolled in the C.U.R.I.A.Mo. (Centro Universitario di Ricerca Interdipartimentale Attivita Motoria) trial. Methods: 102 subjects (56 females and 46 males, aged between 23 and 78) with type 2 diabetes, obesity or a BMI of at least 25 kg/m(2) with comorbidities, participated in the intensive phase of a multidisciplinary lifestyle intervention program at the Healthy Lifestyle Institute of the University of Perugia (C.U.R.I.A.Mo.). Six indices related to NAFLD (Visceral Adiposity Index, Fatty Liver index, Non-Alcoholic Fatty Liver Disease liver fat score and liver fat equation, hepatic steatosis index and TyG index) were calculated before and after a three-month multidisciplinary lifestyle intervention. Results: The intervention improved the anthropometric and clinical parameters in the total population, the obese and/or diabetics. Data showed a significant weight loss, a reduced waist circumference, triglycerides, and an improvement in Mediterranean diet adherence. Hepatic steatosis indices were significantly reduced in the total population and in different subgroups (males, females, obesity and diabetes). C1 [Reginato, Elisa; Pippi, Roberto; Aiello, Cristina; Tomaro, Emilia Sbroma; Ranucci, Claudia; Buratta, Livia; De Feo, Pierpaolo; Fanelli, Carmine] Univ Perugia, Ctr Univ Ric Interdipartimentale Attivita Motoria, CURIAMo, Hlth Lifestyle Inst, Via G Bambagioni 19, I-06126 Perugia, Italy. [Bini, Vittorio] Univ Perugia, Dept Med, I-06126 Perugia, Italy. [Marchesini, Giulio] Alma Mater Univ Bologna, Unit Metab Dis & Clin Dietet, I-40126 Bologna, Italy. C3 University of Perugia; University of Perugia; University of Bologna RP Fanelli, C (通讯作者)，Univ Perugia, Ctr Univ Ric Interdipartimentale Attivita Motoria, CURIAMo, Hlth Lifestyle Inst, Via G Bambagioni 19, I-06126 Perugia, Italy. EM elisa.reginato@gmail.com; robertopippi@gmail.com; cristina.aiello@hotmail.com; emilia.sbroma@virgilio.it; claudiaranucci.diet@gmail.com; liviaburatta@hotmail.it; vittorio.bini@unipg.it; giulio.marchesini@unibo.it; pierpaolodefeo@gmail.com; carmine.fanelli@unipg.it RI Pippi, Roberto/N-9300-2014; Bini, Vittorio/AAA-1104-2019; buratta, livia/AAA-2266-2021; De Feo, Pierpaolo/G-4335-2012 OI Pippi, Roberto/0000-0002-0429-4996; FANELLI, Carmine Giuseppe/0000-0003-4063-158X; Marchesini, Giulio/0000-0003-2407-9860; Bini, Vittorio/0000-0001-8404-2918; FU Department of Health of the Umbria Region (Italy) FX The CURIAMO project is supported by a grant from the Department of Health of the Umbria Region (Italy). 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PD JUN PY 2019 VL 8 IS 6 AR 851 DI 10.3390/jcm8060851 PG 9 WC Medicine, General & Internal WE Science Citation Index Expanded (SCI-EXPANDED) SC General & Internal Medicine GA II7CG UT WOS:000475349300095 PM 31207986 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Dinu, M Whittaker, A Pagliai, G Giangrandi, I Colombini, B Gori, AM Fiorillo, C Becatti, M Casini, A Benedettelli, S Sofi, F AF Dinu, Monica Whittaker, Anne Pagliai, Giuditta Giangrandi, Ilaria Colombini, Barbara Gori, Anna Maria Fiorillo, Claudia Becatti, Matteo Casini, Alessandro Benedettelli, Stefano Sofi, Francesco TI A Khorasan Wheat-Based Replacement Diet Improves Risk Profile of Patients With Nonalcoholic Fatty Liver Disease (NAFLD): A Randomized Clinical Trial SO JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION LA English DT Article DE NAFLD; khorasan; ancient grain; risk factors; steatosis ID MEDITERRANEAN DIET; HEPATIC STEATOSIS; CROSSOVER TRIAL; PATHOGENESIS AB Objective: KAMUT khorasan is an ancient grain with widely acclaimed health benefits. The aim of this study was to investigate the effects of a replacement diet with ancient khorasan wheat products in patients with NAFLD, in comparison to a similar replacement diet with control products made from organic semi-whole-grain modern wheat.Methods: Forty NAFLD patients (12M/28F; age 55.2 10.4years) with mild to moderate liver steatosis were included. The experimental design was a randomized, double-blind, parallel-arm study with 20 participants assigned to consume either KAMUT khorasan or control wheat products (pasta, bread, crackers, biscuits) over a 3-month period. Anthropometric measurements, blood analyses, and ultrasonography examination were performed at both the beginning and end of each dietary intervention.Results: After the implementation of a general linear model for repeated measurements adjusted for baseline demographic details, risk factors, and medication, alanine aminotransferase (ALT) was significantly reduced by 12%, aspartate aminotransferase (AST) by 14%, alkaline phosphatase (ALP) by 8%, and cholesterol by 6% only in the khorasan group (p < 0.05 for all). Similarly, significant reductions in circulating proinflammatory tumor necrosis factor-alpha by 50%, interleukin l-receptor antagonist-alpha by 37%, interleukin-8 by 24%, and interferon gamma by 24% were evident only in participants who consumed the khorasan products (p < 0.05 for all). Finally, significant improvements in the liver steatosis grading, Doppler perfusion index values, and reactive oxygen species (ROS) production were evident after consumption of both the khorasan and control products.Conclusions: This study suggests that a short-term replacement diet with ancient KAMUT khorasan products is most effective in reducing metabolic risk factors and ameliorating the liver profile in patients with NAFLD. C1 [Dinu, Monica; Pagliai, Giuditta; Giangrandi, Ilaria; Colombini, Barbara; Gori, Anna Maria; Casini, Alessandro; Sofi, Francesco] Univ Florence, Sch Human Hlth Sci, Dept Expt & Clin Med, Florence, Italy. [Whittaker, Anne; Benedettelli, Stefano] Univ Florence, Dept Agrifood Prod & Environm Sci, Florence, Italy. [Gori, Anna Maria] Careggi Univ Hosp, Unit Atherothrombot Dis, Florence, Italy. [Fiorillo, Claudia; Becatti, Matteo] Univ Florence, Dept Clin & Expt Biomed Sci, Florence, Italy. [Casini, Alessandro; Sofi, Francesco] Careggi Univ Hosp, Unit Clin Nutr, Florence, Italy. [Sofi, Francesco] Don Carlo Gnocchi Fdn Italy, Onlus IRCCS, Florence, Italy. C3 University of Florence; University of Florence; University of Florence; Azienda Ospedaliero Universitaria Careggi; University of Florence; University of Florence; Azienda Ospedaliero Universitaria Careggi; IRCCS Fondazione Don Carlo Gnocchi Onlus RP Dinu, M (通讯作者)，Univ Florence, Dept Expt & Clin Med, Largo Brambilla 3, I-50134 Florence, Italy. EM mdinu@unifi.it RI Becatti, Matteo/K-9599-2016; Pagliai, Giuditta/K-9592-2016; Sofi, Francesco/J-3941-2016; Dinu, Monica/I-4864-2017; COLOMBINI, Barbara/AAG-3272-2020; Benedettelli, Stefano/M-9760-2015 OI Becatti, Matteo/0000-0002-2593-5908; GIANGRANDI, ILARIA/0000-0001-9230-595X; Sofi, Francesco/0000-0001-7113-7424; Dinu, Monica/0000-0003-1687-2527; COLOMBINI, Barbara/0000-0003-1397-9791; CR Becatti M, 2014, ARTERIOSCL THROM VAS, V34, P1355, DOI 10.1161/ATVBAHA.114.303785 Buzzetti E, 2016, METABOLISM, V65, P1038, DOI 10.1016/j.metabol.2015.12.012 Byrne CD, 2015, J HEPATOL, V62, pS47, DOI 10.1016/j.jhep.2014.12.012 Capanni M, 2006, ALIMENT PHARM THER, V23, P1143, DOI 10.1111/j.1365-2036.2006.02885.x Dinelli G, 2009, J CHROMATOGR A, V1216, P7229, DOI 10.1016/j.chroma.2009.08.041 Kakkos SK, 2000, SCAND J GASTROENTERO, V35, P976, DOI 10.1080/003655200750023066 Obika M, 2012, EXP DIABETES RES, DOI 10.1155/2012/145754 Oliveira CP, 2016, J DIABETES RES, V2016, DOI 10.1155/2016/4597246 Polimeni L, 2015, WORLD J HEPATOL, V7, P1325, DOI 10.4254/wjh.v7.i10.1325 Ross AB, 2013, INT J ENDOCRINOL, V2013, DOI 10.1155/2013/585876 Ryan MC, 2013, J HEPATOL, V59, P138, DOI 10.1016/j.jhep.2013.02.012 Sofi F, 2013, EUR J CLIN NUTR, V67, P190, DOI 10.1038/ejcn.2012.206 Sofi F, 2014, BR J NUTR, V13, P1 Sofi F, 2017, INT J FOOD SCI NUTR, V68, P757, DOI 10.1080/09637486.2017.1287884 Sofi F, 2010, J MED FOOD, V13, P615, DOI 10.1089/jmf.2009.0092 Stojsavljevic S, 2014, WORLD J GASTROENTERO, V20, P18070, DOI 10.3748/wjg.v20.i48.18070 Whittaker A, 2017, EUR J NUTR, V56, P1191, DOI 10.1007/s00394-016-1168-2 Whittaker A, 2015, NUTRIENTS, V7, P3401, DOI 10.3390/nu7053401 NR 18 TC 18 Z9 20 U1 0 U2 6 PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD PI ABINGDON PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 0731-5724 EI 1541-1087 J9 J AM COLL NUTR JI J. Am. Coll. Nutr. PY 2018 VL 37 IS 6 BP 508 EP 514 DI 10.1080/07315724.2018.1445047 PG 7 WC Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Nutrition & Dietetics GA GO3MI UT WOS:000439894700008 PM 29652567 OA Green Submitted, Bronze DA 2026-02-02 ER PT J AU Zhang, YF Qiao, WN Zhuang, JH Feng, HX Zhang, ZL Zhang, Y AF Zhang, Yi-Feng Qiao, Wanning Zhuang, Jinhong Feng, Hanxiao Zhang, Zhilan Zhang, Yang TI Association of ultra-processed food intake with severe non-alcoholic fatty liver disease: a prospective study of 143073 UK Biobank participants SO JOURNAL OF NUTRITION HEALTH & AGING LA English DT Article DE Ultra-processed food; Non-alcoholic fatty liver disease; Cohort; Dietary intake ID MEDITERRANEAN DIET; NAFLD; STEATOHEPATITIS; MANAGEMENT; MICROBIOTA; ADHERENCE; NUTRITION; RISK AB Background: Previous studies indicate a link between non-alcoholic fatty liver disease (NAFLD) and unhealthy dietary patterns or nutrient intake. However, it remains unclear whether ultra-processed foods (UPF) contribute to an increased risk of NAFLD. This study aimed to explore how ultra-processed food consumption correlates with severe NAFLD using the UK Biobank data. Methods: This prospective cohort study included 143,073 participants from the UK Biobank. UPF consumption levels were determined using the NOVA classification and quantified from 24-h dietary recall data. The association between UPF consumption and severe NAFLD (hospitalization or death) was initially examined using Cox proportional hazards models with intake quartiles. Nonlinear associations were investigated using penalized cubic splines fitted in the Cox proportional hazards models. Adjustments were made for general characteristics, sociodemographic factors, body mass index (BMI), and lifestyle. Results: Throughout the median follow-up period of 10.5 years, 1,445 participants developed severe NAFLD. The adjusted models indicated a significant increase in severe NAFLD risk in higher UPF intake groups compared to the lowest quartile (HR: 1.26 [95% CI: 1.11-1.43]). Subgroup analysis revealed that individuals with a BMI of 25 or higher were at greater risk in the highest quartile of UPF consumption. Sensitivity analyses yielded results consistent with these findings. Conclusion: Higher consumption of UPF is associated with an increased risk of severe NAFLD. Reducing the intake of UPF can be a potential approach to lower the risk of NAFLD. (c) 2024 The Author(s). Published by Elsevier Masson SAS on behalf of SERDI Publisher. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). C1 [Zhang, Yi-Feng; Qiao, Wanning; Zhuang, Jinhong; Feng, Hanxiao; Zhang, Zhilan; Zhang, Yang] Sun Yat Sen Univ, Sch Publ Hlth Shenzhen, Shenzhen, Guangdong, Peoples R China. [Zhang, Yang] Sun Yat Sen Univ, Affiliated Hosp 3, Guangdong Prov Key Lab Diabetol, Guangzhou Key Lab Mechanist & Translat Obes Res, Guangzhou, Guangdong, Peoples R China. C3 Sun Yat Sen University; Sun Yat Sen University RP Zhang, Y (通讯作者)，Sun Yat Sen Univ, Sch Publ Hlth Shenzhen, Shenzhen, Guangdong, Peoples R China.; Zhang, Y (通讯作者)，Sun Yat Sen Univ, Affiliated Hosp 3, Guangdong Prov Key Lab Diabetol, Guangzhou Key Lab Mechanist & Translat Obes Res, Guangzhou, Guangdong, Peoples R China. EM zhangy2293@mail.sysu.edu.cn RI Zhang, Yifeng/LKL-0354-2024; Zhang, Yang/ABM-7844-2022; Feng, Hanxiao/LYO-5831-2024 OI Zhang, Yifeng/0009-0008-3752-260X; Zhang, Yang/0000-0002-3636-4856; FU National Natural Science Foundation of China [82000462, 82170883] FX This work was supported by the National Natural Science Foundation of China (82000462 and 82170883) (Yang Zhang) . 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Nutr. Health Aging PD OCT PY 2024 VL 28 IS 10 AR 100352 DI 10.1016/j.jnha.2024.100352 EA SEP 2024 PG 7 WC Geriatrics & Gerontology; Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Geriatrics & Gerontology; Nutrition & Dietetics GA I1W0B UT WOS:001328216200001 PM 39340900 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Zhao, Y Wang, Y Chen, L Chen, HM Tang, YH He, YF Yao, P AF Zhao, Ying Wang, Yu Chen, Li Chen, Huimin Tang, Yuhan He, Yuefeng Yao, Ping TI Accelerated Biological Aging, Genetic Susceptibility, and Non-Alcoholic Fatty Liver Disease: Two Prospective Cohort Studies SO NUTRIENTS LA English DT Article DE biological aging; KDMAge; PhenoAge; non-alcoholic fatty liver disease; polygenic risk score; genetic susceptibility ID LEUKOCYTE TELOMERE LENGTH; MEDITERRANEAN DIET; RISK; AGE; INDIVIDUALS; ASSOCIATION; PREVALENCE; MANAGEMENT; METFORMIN AB Background: Biological aging is considered a vital risk factor for age-related diseases, but its role in non-alcoholic fatty liver disease (NAFLD) remains uncertain. This study aimed to evaluate the associations of biological aging with NAFLD and the modified effect of genetic susceptibility. Methods: This study included 329,040 participants from the UK Biobank and 6783 participants from the Dongfeng-Tongji Cohort in China. We calculated the chronological age-adjusted biological age as a surrogate measure for biological aging. Accelerated aging was defined as biological age that exceeded chronological age. The association between biological aging and the risk of NAFLD was assessed in the two cohorts. Polygenic risk scores (PRSs) were used to determine genetic susceptibility for NAFLD in the UK Biobank and further analyze the interaction with biological aging. Results: In the UK Biobank, one year older in age-adjusted biological age increased prevalent NAFLD risk by 6%. The hazard ratios (HRs) and 95% confidence intervals (95% CIs) of NAFLD by accelerated aging were 1.35 (1.17, 1.56) and 1.69 (1.54, 1.85) compared to non-aging. In the Dongfeng-Tongji Cohort, biological aging was prospectively associated with NAFLD (accelerated aging: odds ratio (OR) (95% CI) = 1.18 (1.03, 1.36)). In the UK Biobank, high genetic risk was significantly associated with higher NAFLD risk compared to low genetic risk (HRs (95% CIs) = 1.65 (1.40, 1.95)). Analyses of joint effects showed that participants with high PRS and accelerated aging had the highest risk of NAFLD [2.66 (2.98, 3.57) and 2.06 (2.36, 3.96)]. However, biological aging was prospectively associated with NAFLD among participants regardless of genetic risk. There was no significant interaction between genetic risk and biological aging. Conclusions: Accelerated biological aging was associated with a higher risk of NAFLD independent of genetic susceptibility. Identifying populations with accelerated biological aging by the use of surrogate measures and timely intervention may be beneficial for the prevention of NAFLD. C1 [Zhao, Ying; He, Yuefeng] Kunming Med Univ, Sch Publ Hlth, Kunming 650500, Peoples R China. [Zhao, Ying; Wang, Yu; Chen, Huimin; Tang, Yuhan; Yao, Ping] Huazhong Univ Sci & Technol, Key Lab Environm & Hlth Wuhan, State Key Lab Environm Hlth Incubat, Minist Educ,Minist Environm Protect,Dept Nutr & Fo, Wuhan 430030, Peoples R China. [Zhao, Ying; Wang, Yu; Chen, Huimin; Tang, Yuhan; Yao, Ping] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, MOE Key Lab Environm & Hlth, Wuhan 430030, Peoples R China. [Chen, Li] Chinese Acad Agr Sci, Hubei Key Lab Lipid Chem & Nutr, Oil Crops & Lipids Proc Technol Natl & Local Joint, Minist Agr,Oil Crops Res Inst, Wuhan 430062, Peoples R China. [Chen, Li] Chinese Acad Agr Sci, Oil Crops Res Inst, Key Lab Oilseeds Proc, Wuhan 430062, Peoples R China. C3 Kunming Medical University; Huazhong University of Science & Technology; Huazhong University of Science & Technology; Chinese Academy of Agricultural Sciences; Oil Crops Research Institute, CAAS; Chinese Academy of Agricultural Sciences; Oil Crops Research Institute, CAAS RP He, YF (通讯作者)，Kunming Med Univ, Sch Publ Hlth, Kunming 650500, Peoples R China.; Yao, P (通讯作者)，Huazhong Univ Sci & Technol, Key Lab Environm & Hlth Wuhan, State Key Lab Environm Hlth Incubat, Minist Educ,Minist Environm Protect,Dept Nutr & Fo, Wuhan 430030, Peoples R China.; Yao, P (通讯作者)，Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, MOE Key Lab Environm & Hlth, Wuhan 430030, Peoples R China. EM zhaoying1@kmmu.edu.cn; wy128137@163.com; chenli05@caas.cn; d202081547@hust.edu.cn; 2015220157@hust.edu.cn; heyuefeng@kmmu.edu.cn; yaoping@mails.tjmu.edu.cn OI Yao, Ping/0000-0002-0192-9546 FU The National Natural Science Foundation of China [81973044]; National Natural Science Foundation of China FX The study was supported by the National Natural Science Foundation of China (No. 81973044). 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There is strong evidence that dyslipidemia and other cardio-metabolic disorders are highly prevalent in patients with NAFLD. This trial aimed at examining the effect of sesame oil (SO) in the context of a weight loss program on lipid profile, blood pressure, and anthropometric indices in women with NAFLD. Methods: This randomized, double-blind, controlled trial was carried out on 60 women with NAFLD. Subjects were randomly assigned to the SO group (n = 30) and sunflower oil (SFO) group (n = 30), each person consuming 30 g of oil per day for 12 weeks. All the participants received a hypocaloric diet (- 500 kcal/day) during the study. Lipid profile, blood pressure, and anthropometric indices were assessed at pre- and post-intervention phases. Results: In total, 53 participants completed the study. Following 12 weeks of intervention, anthropometric indices (p < 0.001) and systolic blood pressure (SBP) (p < 0.05) were significantly decreased in both groups and diastolic blood pressure (DBP) was significantly decreased in So group (p = 0.03). There was no significant change in lipid profile in both groups (p > 0.05). After adjusting for confounders, DBP (p = 0.031) and total cholesterol (TC) divided by high-density lipoprotein cholesterol (HDL-C) (p = 0.039) in the SO group were significantly reduced compared to the SFO group (p < 0.05). Conclusions: The present clinical trial revealed that SO and SFO may not differently affect anthropometric indices, SBP, and lipid profile except for TC/HDL-C. In addition, SO may be effective in improvement of DBP and TC/HDL-C compared to the SFO group. C1 [Vahedi, Hamid] Shahroud Univ Med Sci, Sch Med, Dept Gastroenterol, Shahroud, Iran. [Atefi, Masoumeh] Isfahan Univ Med Sci, Sch Nutr & Food Sci, Dept Clin Nutr, Esfahan, Iran. [Entezari, Mohammad Hassan] Isfahan Univ Med Sci, Food Secur Res Ctr, Esfahan, Iran. [Entezari, Mohammad Hassan] Isfahan Univ Med Sci, Sch Nutr & Food Sci, Dept Clin Nutr, Esfahan, Iran. [Hassanzadeh, Akbar] Isfahan Univ Med Sci, Sch Hlth, Dept Epidemiol & Biostat, Esfahan, Iran. C3 Shahroud University Medical Sciences; Isfahan University of Medical Sciences; Isfahan University of Medical Sciences; Isfahan University of Medical Sciences; Isfahan University of Medical Sciences RP Entezari, MH (通讯作者)，Isfahan Univ Med Sci, Food Secur Res Ctr, Esfahan, Iran.; Entezari, MH (通讯作者)，Isfahan Univ Med Sci, Sch Nutr & Food Sci, Dept Clin Nutr, Esfahan, Iran. EM entezari@hlth.mui.ac.ir RI Atefi, Masoumeh/AAE-1965-2022; entezari, mohammadhassan/V-6033-2017; Vahedi, Hamid/AIE-3270-2022; Hassanzadeh, Akbar/V-5970-2017 OI Atefi, Masoumeh/0000-0003-3984-166X; FU Isfahan University of Medical Sciences [399632] FX This work was supported by the Isfahan University of Medical Sciences under grant number 399632. 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JOURNAL OF GASTROENTEROLOGY LA English DT Article DE Hepatic steatosis; Non-alcoholic fatty liver disease; Omega-3 polyunsaturated fatty acids; Animal models ID ACTIVATED-RECEPTOR-ALPHA; ELEMENT-BINDING PROTEIN-1; AMELIORATE HEPATIC STEATOSIS; OXIDATIVE STRESS; INSULIN-RESISTANCE; GENE-EXPRESSION; ACID REGULATION; MURINE MODEL; MOLECULAR-MECHANISMS; METABOLIC SYNDROME AB Non-alcoholic fatty liver disease (NAFLD) has been recognized as a major health burden. It is the most important cause of chronic liver disease and a major independent cardiovascular risk factor. Lacking a definite treatment for NAFLD, a specific diet and an increase in physical activity represent the most commonly used therapeutic approaches. In this review, major literature data about the use of omega-3 polyunsaturated fatty acids (n-3 PUFAs) as a potential treatment of NAFLD have been described. n-3 PUFAs, besides having a beneficial impact on most of the cardio-metabolic risk factors (hypertension, hyperlipidemia, endothelial dysfunction and atherosclerosis) by regulating gene transcription factors [i.e., peroxisome proliferator-activated receptor (PPAR) alpha, PPAR gamma, sterol regulatory element-binding protein-1, carbohydrate responsive element-binding protein], impacts both lipid metabolism and on insulin sensitivity. In addition to an enhancement of hepatic beta oxidation and a decrease of the endogenous lipid production, n-3 PUFAs are able to determine a significant reduction of the expression of pro-inflammatory molecules (tumor necrosis factor-alpha and interleukin-6) and of oxygen reactive species. Further strengthening the results of the in vitro studies, both animal models and human intervention trials, showed a beneficial effect of n-3 PUFAs on the severity of NAFLD as expressed by laboratory parameters and imaging measurements. Despite available results provided encouraging data about the efficacy of n-3 PUFAs as a treatment of NAFLD in humans, well-designed randomized controlled trials of adequate size and duration, with histological endpoints, are needed to assess the long-term safety and efficacy of PUFA, as well as other therapies, for the treatment of NAFLD and non-alcoholic steatohepatitis patients. It is worthwhile to consider that n-3 PUFAs cannot be synthesized by the human body and must be derived from exogenous sources (fish oil, flaxseeds, olive oil) which are typical foods of the Mediterranean diet, known for its beneficial effects in preventing obesity, diabetes and, in turn, cardiovascular events. According to these data, it is important to consider that most of the beneficial effects of n-3 PUFAs can also be obtained by an equilibrate nutrition program. (C) 2012 Baishideng. All rights reserved. C1 [Di Minno, Matteo Nicola Dario; Russolillo, Anna; Lupoli, Roberta; Ambrosino, Pasquale; Di Minno, Alessandro; Tarantino, Giovanni] Univ Naples Federico II, Dept Clin & Expt Med, Reg Reference Ctr Coagulat Disorders, I-80131 Naples, Italy. C3 University of Naples Federico II RP Di Minno, MND (通讯作者)，Univ Naples Federico II, Dept Clin & Expt Med, Reg Reference Ctr Coagulat Disorders, Via S Pansini 5, I-80131 Naples, Italy. 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Gastroenterol. PD NOV 7 PY 2012 VL 18 IS 41 BP 5839 EP 5847 DI 10.3748/wjg.v18.i41.5839 PG 9 WC Gastroenterology & Hepatology WE Science Citation Index Expanded (SCI-EXPANDED) SC Gastroenterology & Hepatology GA 038SU UT WOS:000311195200002 PM 23139599 OA Green Submitted, hybrid DA 2026-02-02 ER PT J AU Papamiltiadous, ES Roberts, SK Nicoll, AJ Ryan, MC Itsiopoulos, C Salim, A Tierney, AC AF Papamiltiadous, Elena S. Roberts, Stuart K. Nicoll, Amanda J. Ryan, Marno C. Itsiopoulos, Catherine Salim, Agus Tierney, Audrey C. TI A randomised controlled trial of a Mediterranean Dietary Intervention for Adults with Non Alcoholic Fatty Liver Disease (MEDINA): study protocol SO BMC GASTROENTEROLOGY LA English DT Article DE Non-alcoholic fatty liver disease; Mediterranean diet; Fatty liver; Insulin resistance ID WEIGHT-LOSS; METABOLIC SYNDROME; PREVALENCE; STEATOSIS; MARKERS AB Background: Non-alcoholic fatty liver disease, the most prevalent liver disease in developed countries, remains difficult to manage with no proven safe and effective pharmacotherapy available. While weight reduction is the most commonly practiced treatment strategy, this is difficult to both achieve and/or maintain in the majority. Furthermore evidence-based dietary recommendations to guide the nutritional management of these patients are lacking. Using a randomised controlled trial design, this study compares the effectiveness of the Mediterranean diet to a standard low fat diet in terms of differences in insulin sensitivity, hepatic steatosis and metabolic outcomes in participants with non-alcoholic fatty liver disease. Methods: Ninety four eligible patients who have non-alcoholic fatty liver disease and who are insulin resistant, will be randomised into either a Mediterranean or low fat diet group for a 3 month intervention period. Insulin sensitivity will be measured on peripheral blood using Homeostatic Model Assessment and liver fat content quantified using Magnetic Resonance Spectroscopy. Both arms will consist of three face to face and three telephone call follow up consultations delivered by an Accredited Practicing Dietitian. The intervention arm focuses on recommendations from the traditional Mediterranean diet which have been tailored for use in the Australian population The standard arm uses the Australian Guide to Healthy Eating and the Australian National Heart Foundation dietary guidelines. Study recruitment will take place at four major metropolitan hospitals in Melbourne, Australia. Data collection will occur at all face to face reviews including baseline, 6, and 12 weeks. A follow up assessment to measure sustainability will take place at 6 and 12 months. The primary end point is improved insulin sensitivity scores at the 12 week time point. Discussion: This trial aims to demonstrate in a large cohort of participants with NALFD that a Mediterranean diet independent of weight loss can result in significant benefits in liver fat and insulin sensitivity and that these changes are sustained at 12 months. These metabolic changes would potentially lead to reductions in the risk of chronic liver disease, heart disease, type 2 diabetes and liver cancer. C1 [Papamiltiadous, Elena S.; Itsiopoulos, Catherine; Tierney, Audrey C.] La Trobe Univ, Nutr & Sports, Dept Rehabil, Kingsbury Dr, Bundoora, Vic, Australia. [Roberts, Stuart K.] Alfred Hosp, Dept Gastroenterol, Commercial Rd, Prahran, Vic 3181, Australia. [Nicoll, Amanda J.] Dept Gastroenterol, 8 Arnold St, Box Hill, Vic, Australia. [Ryan, Marno C.] St Vincents Hosp, Dept Gastroenterol, Fitzroy, Vic 3065, Australia. [Salim, Agus] La Trobe Univ, Dept Math & Stat, Kingsbury Dr, Bundoora, Vic, Australia. [Tierney, Audrey C.] Alfred Hosp, Dept Nutr, Commercial Rd, Prahran, Vic 3181, Australia. C3 La Trobe University; Florey Institute of Neuroscience & Mental Health; Howard Florey Institute Affiliates; NSW Health; St Vincents Hospital Sydney; St Vincent's Health; St Vincent's Hospital Melbourne; La Trobe University; Florey Institute of Neuroscience & Mental Health; Howard Florey Institute Affiliates RP Papamiltiadous, ES (通讯作者)，La Trobe Univ, Nutr & Sports, Dept Rehabil, Kingsbury Dr, Bundoora, Vic, Australia. EM E.Papamiltiadous@latrobe.edu.au RI Tierney, Auey/AAB-7068-2022; Salim, Agus/P-1407-2014 OI Tierney, Auey/0000-0001-8562-2877; Salim, Agus/0000-0003-3999-7701; Roberts, Stuart/0000-0002-9015-7997; Nicoll, Amanda/0000-0002-1855-2757; Itsiopoulos, Catherine/0000-0003-1397-4149 FU La Trobe University Research Focus Area Game Changing Grant FX Cobram Estate, The Almond Board of Australia, Jalna, Simplot Heinz and Carman's for supplying food for the intervention participants. This study is partially funded by a La Trobe University Research Focus Area Game Changing Grant. 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PD FEB 2 PY 2016 VL 16 AR 14 DI 10.1186/s12876-016-0426-3 PG 7 WC Gastroenterology & Hepatology WE Science Citation Index Expanded (SCI-EXPANDED) SC Gastroenterology & Hepatology GA DC2MO UT WOS:000369051000001 PM 26831892 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Radu, F Potcovaru, CG Salmen, T Filip, PV Pop, C Fierbinteanu-Braticievici, C AF Radu, Fabiana Potcovaru, Claudia-Gabriela Salmen, Teodor Filip, Petruta Violeta Pop, Corina Fierbinteanu-Braticievici, Carmen TI The Link between NAFLD and Metabolic Syndrome SO DIAGNOSTICS LA English DT Review DE metabolic syndrome; insulin resistance; NAFLD; early diagnosis; hepatocellular carcinoma ID FATTY LIVER-DISEASE; MAGNETIC-RESONANCE ELASTOGRAPHY; RADIATION FORCE IMPULSE; NONALCOHOLIC STEATOHEPATITIS; HEPATIC STEATOSIS; ADVANCED FIBROSIS; TRANSIENT ELASTOGRAPHY; CARDIOVASCULAR-DISEASE; NONINVASIVE ASSESSMENT; DIAGNOSIS AB Metabolic syndrome (MetS) is characterized by an association of cardiovascular and diabetes mellitus type 2 risk factors. Although the definition of MetS slightly differs depending on the society that described it, its central diagnostic criteria include impaired fasting glucose, low HDL-cholesterol, elevated triglycerides levels and high blood pressure. Insulin resistance (IR) is believed to be the main cause of MetS and is connected to the level of visceral or intra-abdominal adipose tissue, which could be assessed either by calculating body mass index or by measuring waist circumference. Most recent studies revealed that IR may also be present in non-obese patients, and considered visceral adiposity to be the main effector of MetS' pathology. Visceral adiposity is strongly linked with hepatic fatty infiltration also known as non-alcoholic fatty liver disease (NAFLD), therefore, the level of fatty acids in the hepatic parenchyma is indirectly linked with MetS, being both a cause and a consequence of this syndrome. Taking into consideration the present pandemic of obesity and its tendency to drift towards a progressively earlier onset due to the Western lifestyle, it leads to an increased NAFLD incidence. Novel therapeutic resources are lifestyle intervention with physical activity, Mediterranean diet, or therapeutic surgical respective metabolic and bariatric surgery or drugs such as SGLT-2i, GLP-1 Ra or vitamin E. NAFLD early diagnosis is important due to its easily available diagnostic tools such as non-invasive tools: clinical and laboratory variables (serum biomarkers): AST to platelet ratio index, fibrosis-4, NAFLD Fibrosis Score, BARD Score, fibro test, enhanced liver fibrosis; imaging-based biomarkers: Controlled attenuation parameter, magnetic resonance imaging proton-density fat fraction, transient elastography (TE) or vibration controlled TE, acoustic radiation force impulse imaging, shear wave elastography, magnetic resonance elastography; and the possibility to prevent its complications, respectively, fibrosis, hepato-cellular carcinoma or liver cirrhosis which can develop into end-stage liver disease. C1 [Radu, Fabiana; Potcovaru, Claudia-Gabriela; Salmen, Teodor] Carol Davila Univ Med & Pharm, Doctoral Sch, Bucharest 050474, Romania. [Filip, Petruta Violeta; Pop, Corina] Clin Emergency Univ Hosp, Dept Gastroenterol & Internal Med, Bucharest 050098, Romania. 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Younossi ZM, 2018, HEPATOLOGY, V68, P349, DOI 10.1002/hep.29721 Zatloukal K, 2007, EXP CELL RES, V313, P2033, DOI 10.1016/j.yexcr.2007.04.024 NR 81 TC 62 Z9 71 U1 2 U2 28 PU MDPI PI BASEL PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND EI 2075-4418 J9 DIAGNOSTICS JI Diagnostics PD FEB PY 2023 VL 13 IS 4 AR 614 DI 10.3390/diagnostics13040614 PG 13 WC Medicine, General & Internal WE Science Citation Index Expanded (SCI-EXPANDED) SC General & Internal Medicine GA 9Q5CY UT WOS:000944983100001 PM 36832102 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Konieczna, J Fiol, M Colom, A Martínez-González, MA Salas-Salvadó, J Corella, D Soria-Florido, MT Martínez, JA Alonso-Gómez, AM Wärnberg, J Vioque, J López-Miranda, J Estruch, R Bernal-López, MR Lapetra, J Serra-Majem, L Bueno-Cavanillas, A Tur, JA Sánchez, VM Pintó, X Gaforio, JJ Matía-Martín, P Vidal, J Vázquez, C Daimiel, L Ros, E Bes-Rastrollo, M Pascual, M Sorli, JV Goday, A Zulet, MA Moreno-Rodriguez, A González, FJC Valls-Enguix, R Janer, JM Garcia-Rios, A Casas, R Gomez-Perez, AM Santos-Lozano, JM Basterra-Gortari, FJ Martínez, MA Ortega-Azorin, C Bayó, J Abete, I Salaverria-Lete, I Ruiz-Canela, M Babio, N Carres, L Romaguera, D AF Konieczna, Jadwiga Fiol, Miguel Colom, Antoni Angel Martinez-Gonzalez, Miguel Salas-Salvado, Jordi Corella, Dolores Trinidad Soria-Florido, Maria Alfredo Martinez, J. Alonso-Gomez, Angel M. Warnberg, Julia Vioque, Jesus Lopez-Miranda, Jose Estruch, Ramon Rosa Bernal-Lopez, M. Lapetra, Jose Serra-Majem, Lluis Bueno-Cavanillas, Aurora Tur, Josep A. Martin Sanchez, Vicente Pinto, Xavier Gaforio, Jose J. Matia-Martin, Pilar Vidal, Josep Vazquez, Clotilde Daimiel, Lidia Ros, Emilio Bes-Rastrollo, Maira Pascual, Maria Sorli, Jose, V Goday, Albert Angeles Zulet, Maria Moreno-Rodriguez, Anai Carmona Gonzalez, Francisco Jesus Valls-Enguix, Rafael Janer, Juana M. Garcia-Rios, Antonio Casas, Rosa Gomez-Perez, Ana M. Manuel Santos-Lozano, Jose Javier Basterra-Gortari, F. Angeles Martinez, Maria Ortega-Azorin, Carolina Bayo, Joan Abete, Itziar Salaverria-Lete, Itziar Ruiz-Canela, Miguel Babio, Nancy Carres, Lourdes Romaguera, Dora TI Does Consumption of Ultra-Processed Foods Matter for Liver Health? Prospective Analysis among Older Adults with Metabolic Syndrome SO NUTRIENTS LA English DT Article DE ultra-processed foods; liver health markers; fatty liver index; hepatic steatosis index; metabolic syndrome ID MEDITERRANEAN DIET ADHERENCE; PHYSICAL-ACTIVITY; GLYCEMIC INDEX; DISEASE; RISK; QUESTIONNAIRE; VALIDATION; NUTRITION; LOAD AB Non-alcoholic fatty liver disease (NAFLD) includes a spectrum of liver alterations that can result in severe disease and even death. Consumption of ultra-processed foods (UPF) has been associated with obesity and related comorbidities. However, the link between UPF and NAFLD has not been sufficiently assessed. We aimed to investigate the prospective association between UPF consumption and liver health biomarkers. Methods: We followed for 1 year 5867 older participants with overweight/obesity and metabolic syndrome (MetS) from the PREDIMED-Plus trial. A validated 143-item semi-quantitative food frequency questionnaire was used to evaluate consumption of UPF at baseline, 6, and 12 months. The degree of processing for foods and beverages (g/day) was established according to the NOVA classification system. The non-invasive fatty liver index (FLI) and hepatic steatosis index (HSI) were used to evaluate liver health at three points in time. The associations between changes in UPF consumption (percentage of total daily dietary intake (g)) and liver biomarkers were assessed using mixed-effects linear models with repeated measurements. Results: In this cohort, UPF consumption at baseline was 8.19% (SD 6.95%) of total daily dietary intake in grams. In multivariable models, each 10% daily increment in UPF consumption in 1 year was associated with significantly greater FLI (beta 1.60 points, 95% CI 1.24;1.96 points) and HSI (0.43, 0.29; 0.57) scores (all p-values < 0.001). These associations persisted statistically significant after adjusting for potential dietary confounders and NAFLD risk factors. Conclusions: A higher UPF consumption was associated with higher levels of NAFLD-related biomarkers in older adults with overweight/obesity and MetS. C1 [Konieczna, Jadwiga; Fiol, Miguel; Colom, Antoni; Romaguera, Dora] Univ Hosp Son Espases HUSE, Hlth Res Inst Balearic Isl IdISBa, Res Grp Nutr Epidemiol & Cardiovasc Physiopathol, Palma De Mallorca 07120, Spain. [Konieczna, Jadwiga; Fiol, Miguel; Colom, Antoni; Angel Martinez-Gonzalez, Miguel; Salas-Salvado, Jordi; Corella, Dolores; Trinidad Soria-Florido, Maria; Alfredo Martinez, J.; Lopez-Miranda, Jose; Estruch, Ramon; Pinto, Xavier; Pascual, Maria; Sorli, Jose, V; Moreno-Rodriguez, Anai; Gomez-Perez, Ana M.; Manuel Santos-Lozano, Jose; Angeles Martinez, Maria; Ortega-Azorin, Carolina; Ruiz-Canela, Miguel; Babio, Nancy; Romaguera, Dora] Inst Hlth Carlos III, Ctr Invest Biomed Red Fisiopatol Obesidad & Nutr, Madrid 28029, Spain. [Angel Martinez-Gonzalez, Miguel; Bes-Rastrollo, Maira; Javier Basterra-Gortari, F.; Ruiz-Canela, Miguel] Univ Navarra, Dept Prevent Med & Publ Hlth, IDISNA, Pamplona 31008, Spain. [Angel Martinez-Gonzalez, Miguel] Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA. [Salas-Salvado, Jordi; Pascual, Maria; Angeles Martinez, Maria; Babio, Nancy] Univ Rovira & Virgili, Dept Bioquim & Biotecnol, Unitat Nutr, Reus 43201, Spain. [Salas-Salvado, Jordi; Pascual, Maria; Angeles Martinez, Maria; Babio, Nancy] Univ Hosp St Joan Reus, Nutr Unit, Reus 43204, Spain. [Salas-Salvado, Jordi; Pascual, Maria; Angeles Martinez, Maria; Babio, Nancy] Inst Invest Sanitaria Pere Virgili IISPV, Reus 43204, Spain. [Corella, Dolores; Sorli, Jose, V; Ortega-Azorin, Carolina] Univ Valencia, Dept Prevent Med, Valencia 46010, Spain. [Trinidad Soria-Florido, Maria; Goday, Albert] Inst Hosp del Mar Invest Med Municipal Invest Med, Unit Cardiovasc Risk & Nutr, Barcelona 08003, Spain. [Angeles Zulet, Maria; Abete, Itziar] Univ Navarra, Dept Nutr Food Sci & Physiol, IDISNA, Pamplona 31008, Spain. [Alfredo Martinez, J.] CEI UAM CSIC, IMDEA Food, Precis Nutr & Cardiometab Hlth Program, Madrid 28049, Spain. [Alonso-Gomez, Angel M.; Salaverria-Lete, Itziar] Univ Basque Country UPV EHU, Araba Univ Hosp,Cardiovasc Resp & Metab Area, Bioaraba Hlth Res Inst, Osakidetza Basque Hlth Serv, Vitoria 01009, Spain. [Warnberg, Julia] Univ Malaga, Inst Biomed Res Malaga IBIMA, Dept Nursing, Malaga 29016, Spain. [Vioque, Jesus; Gaforio, Jose J.] Inst Salud Carlos III, CIBER Epidemiol & Salud Publ CIBERESP, Madrid 28029, Spain. [Vioque, Jesus] Alicante Inst Hlth & Biomed Res ISABIAL UMH, Alicante 03010, Spain. [Lopez-Miranda, Jose; Garcia-Rios, Antonio] Univ Cordoba, Reina Sofia Univ Hosp, Maimonides Biomed Res Inst Cordoba IMIBIC, Dept Internal Med, Cordoba 14004, Spain. [Estruch, Ramon; Casas, Rosa] Univ Barcelona, Hosp Clin, Inst Invest Biomed August Pi Sunyer IDIBAPS, Dept Internal Med, Barcelona 08007, Spain. [Rosa Bernal-Lopez, M.] Univ Malga, Reg Univ Hosp Malaga, Inst Invest Biomed Malaga IBIMA, Dept Internal Med, Malaga 29009, Spain. [Lapetra, Jose; Manuel Santos-Lozano, Jose] Dist Sanitario Atenc Primaria Sevilla, Res Unit, Dept Family Med, Seville 41013, Spain. [Serra-Majem, Lluis] Univ Las Palmas Gran Canaria, Res Inst Biomed & Hlth Sci IUIBS, Las Palmas Gran Canaria 35001, Spain. [Serra-Majem, Lluis] Ctr Hosp Univ Insular Materno Infantil CHUIMI, Canarian Hlth Serv, Las Palmas Gran Canaria 35001, Spain. [Bueno-Cavanillas, Aurora] Univ Granada, Dept Prevent Med & Publ Hlth, Granada 18011, Spain. [Tur, Josep A.] Univ Balearic Isl, Res Grp Community Nutr & Oxidat Stress, Palma De Mallorca 07122, Spain. [Martin Sanchez, Vicente] Univ Leon, Inst Biomed IBIOMED, Leon 24071, Spain. [Pinto, Xavier] Hosp Univ Bellvitge Idibell UB, Lipids & Vasc Risk Unit, Internal Med, Barcelona 08907, Spain. [Gaforio, Jose J.] Univ Jaen, Ctr Estudios Avanzados Olivar & Aceites de Oliva, Dept Ciencias Salud, Jaen 23071, Spain. [Matia-Martin, Pilar] Inst Invest Sanitaria Hosp Clin San Carlos IdISSC, Dept Endocrinol & Nutr, Madrid 28040, Spain. [Vidal, Josep] Inst Salud Carlos III ISCIII, CIBER Diabet & Enfermedades Metab CIBERDEM, Madrid 28029, Spain. [Vidal, Josep] Univ Barcelona, Hosp Clin, Inst Invest Biomed August Pi Sunyer IDIBAPS, Dept Endocrinol, Barcelona 08007, Spain. [Vazquez, Clotilde] Univ Autonoma, Hosp Fdn Jimenez Diaz, Inst Invest Biomed IISFJD, Dept Endocrinol & Nutr, Madrid 28040, Spain. [Daimiel, Lidia] CEI UAM CSIC, IMDEA Food, Precis Nutr & Obes Program, Nutr Control Epigenome Grp, Madrid 28049, Spain. [Ros, Emilio] Hosp Clin Barcelona, Dept Endocrinol & Nutr, IDIBAPS, Lipid Clin, Barcelona 08036, Spain. [Goday, Albert] Univ Autonoma Barcelona, Dept Med, Barcelona 08193, Spain. [Carmona Gonzalez, Francisco Jesus] Serv Andaluz Salud, Dist Atenc Primaria Costa del Sol, Unidad Gest Clin Torrequebrada, Benalmadena 29640, Spain. [Valls-Enguix, Rafael] Raval Hlth Care Ctr, Elche 03203, Spain. [Janer, Juana M.] Gerencia Atencio Primaria Mallorca, UBS Son Sardina, Ctr Salud Camp Redo, Palma De Mallorca 07010, Spain. [Gomez-Perez, Ana M.] Univ Malaga, Virgen de la Victoria Hosp, Inst Invest Biomed Malaga IBIMA, Dept Endocrinol, Malaga 29071, Spain. [Javier Basterra-Gortari, F.] Complejo Hosp Navarra, Serv Navarro Salud, Serv Endocrinol, Pamplona 31003, Spain. [Bayo, Joan] Inst Catala Salut, Cap El Clot, Barcelona 08018, Spain. [Carres, Lourdes] Inst Catala Salut, Atenc Primaria St Marti, Barcelona 08020, Spain. C3 Hospital Universitari Son Espases; Institut Investigacio Sanitaria Illes Balears (IdISBa); CIBER - Centro de Investigacion Biomedica en Red; CIBEROBN; University of Navarra; Harvard University; Harvard T.H. Chan School of Public Health; Universitat Rovira i Virgili; Universitat Rovira i Virgili; Institut d'Investigacio Sanitaria Pere Virgili (IISPV); University of Valencia; University of Navarra; IMDEA Food Institute; Consejo Superior de Investigaciones Cientificas (CSIC); University of Basque Country; Bioaraba Health Research Institute; University Hospital of Araba; Universidad de Malaga; IBIMA Plataforma BIONAND, Instituto de Investigacion Biomedica de Malaga; Instituto de Salud Carlos III; CIBER - Centro de Investigacion Biomedica en Red; CIBERESP; Universidad de Cordoba; University of Barcelona; Hospital Clinic de Barcelona; IDIBAPS; IBIMA Plataforma BIONAND, Instituto de Investigacion Biomedica de Malaga; Universidad de Malaga; Universidad de Las Palmas de Gran Canaria; University of Granada; Universitat de les Illes Balears; Universidad de Leon; Institut d'Investigacio Biomedica de Bellvitge (IDIBELL); Bellvitge University Hospital; Universidad de Jaen; CIBER - Centro de Investigacion Biomedica en Red; CIBERDEM; University of Barcelona; Hospital Clinic de Barcelona; IDIBAPS; Fundacion Jimenez Diaz; Autonomous University of Madrid; IMDEA Food Institute; Consejo Superior de Investigaciones Cientificas (CSIC); University of Barcelona; Hospital Clinic de Barcelona; IDIBAPS; Autonomous University of Barcelona; IBIMA Plataforma BIONAND, Instituto de Investigacion Biomedica de Malaga; Universidad de Malaga; Servicio Navarro de Salud - Osasunbidea; Institut Catala de la Salut (ICS); Institut Catala de la Salut (ICS) RP Konieczna, J (通讯作者)，Univ Hosp Son Espases HUSE, Hlth Res Inst Balearic Isl IdISBa, Res Grp Nutr Epidemiol & Cardiovasc Physiopathol, Palma De Mallorca 07120, Spain.; Konieczna, J (通讯作者)，Inst Hlth Carlos III, Ctr Invest Biomed Red Fisiopatol Obesidad & Nutr, Madrid 28029, Spain. EM jadwiga.konieczna@ssib.es RI Tur, Josep/AAE-5748-2020; BABIO SÁNCHEZ, NANCY/AAN-2715-2020; BES-RASTROLLO, MAIRA/AAE-7669-2019; Daimiel-Ruiz, Lidia Ángeles/M-7779-2014; Alonso Gomez, Angel María/HLG-2476-2023; Colom Fernández, Antoni/JHU-4849-2023; Salas-Salvadó, Jordi/C-7229-2017; Ruiz-Canela, Miguel/JYP-1794-2024; Casas, Rosa/ABD-1915-2020; Warnberg, Julia/G-1390-2011; Sorlí, José V/L-8758-2014; Pintó Sala, Xavier/AGI-4297-2022; Bueno Cavanillas, Aurora/O-1513-2015; BES-RASTROLLO, MAIRA/A-1329-2009; Vioque, Jesus/A-1066-2008; Martin, Vicente/A-1597-2008; Zulet, M Angeles/H-1317-2017; Romaguera, Dora/ABE-7004-2020; Corella, Dolores/L-9888-2014; Lopez-Miranda, Jose/Y-8306-2019; Estruch, Ramon/AAZ-3723-2020; Vidal, Josep/MIK-6936-2025; Konieczna, Jadwiga/AAB-2817-2020; Martínez, María Ángeles/ABH-6345-2020; Lapetra, Jose/F-2552-2015; Bernal-Lopez, M/N-3564-2016; SORIA FLORIDO, MARIA TRINIDAD/ABA-2522-2020; Abete, Itziar/H-4827-2017; Martinez-Gonzalez, Miguel A/AAE-7669-2019 OI Tur, Josep/0000-0002-6940-0761; BABIO SÁNCHEZ, NANCY/0000-0003-3527-5277; BES-RASTROLLO, MAIRA/0000-0002-9139-4206; Daimiel-Ruiz, Lidia Ángeles/0000-0001-9898-6629; Alonso Gomez, Angel María/0000-0003-2945-7509; Colom Fernández, Antoni/0000-0001-5041-0778; Martínez Rodríguez, María Ángeles/0000-0001-8595-3772; Salas-Salvadó, Jordi/0000-0003-2700-7459; Ruiz-Canela, Miguel/0000-0002-7684-2787; Gaforio, Jose J/0000-0003-2996-9301; Casas, Rosa/0000-0002-0211-9166; Warnberg, Julia/0000-0002-8408-316X; Sorlí, José V/0000-0002-0130-2006; Pintó Sala, Xavier/0000-0002-2216-2444; Gómez Pérez, Ana María/0000-0002-2874-5894; Bueno Cavanillas, Aurora/0000-0002-0649-3016; CAROLINA, ORTEGA-AZORÍN/0000-0001-6719-9358; BES-RASTROLLO, MAIRA/0000-0002-9139-4206; Vioque, Jesus/0000-0002-2284-148X; Martin, Vicente/0000-0003-0552-2804; Janer Llobera, Juana Maria/0000-0003-3538-5329; Zulet, M Angeles/0000-0002-3926-0892; Romaguera, Dora/0000-0002-5762-8558; Corella, Dolores/0000-0002-2366-4104; Lopez-Miranda, Jose/0000-0002-8844-0718; Estruch, Ramon/0000-0003-1260-4445; Serra-Majem, Lluis/0000-0002-9658-9061; SORIA FLORIDO, MARIA TRINIDAD/0000-0002-5625-9033; Abete, Itziar/0000-0002-6475-5387; Martinez-Gonzalez, Miguel A/0000-0002-3917-9808 FU European Research Council [340918]; Spanish National Health Institute of Health Carlos III (ISCIII), through CIBEROBN; European Regional Development Fund [PI13/00673, PI13/00492, PI13/00272, PI13/01123, PI13/00462, PI13/00233, PI13/02184, PI13/00728, PI13/01090, PI13/01056, PI14/01722, PI14/00636, PI14/00618, PI14/00696, PI14/01206]; Especial Action Project entitled: Implementacion y evaluacion de una intervencion intensiva sobre la actividad fisica Cohorte PREDIMED-Plus grant; Recercaixa [2013ACUP00194]; Consejeria de Salud de la Junta de Andalucia [PI0458/2013, PS0358/2016, PI0137/2018, RH-0024-2021]; Generalitat Valenciana [PROMETEO/2017/017]; SEMERGEN grant; Spanish Ministry of Economy, Industry and Competitiveness [IJC2019-042420-I]; European Social Funds; Spanish National Health Institute of Health Carlos III (ISCIII) [CPII20/00014]; ICREA; The European Regional Development Fund [PI17/00855, PI17/01347, PI17/00525, PI17/01827, PI17/00532, PI17/00215, PI17/01441, PI17/00508, PI17/01732, PI17/00926, PI19/00957, PI19/00386, PI19/00309, PI19/01032, PI19/00576]; 'European Regional Development Fund' [PI19/00017, PI19/01226, PI19/00781, PI19/01560, PI19/01332, PI20/01802, PI20/00138, PI20/01532, PI20/00456, PI20/00339, PI20/00557, PI20/00886, PI20/01158, PI21/00465]; "Fondo de Investigacion para la Salud" (FIS); "European Regional Development Fund" [PI14/01919, PI14/00853, PI14/01374, PI14/00972, PI14/00728, PI14/01471, PI16/00473, PI16/00662, PI16/01873, PI16/01094, PI16/00501, PI16/00533, PI16/00381, PI16/00366, PI16/01522, PI16/01120, PI17/00764, PI17/01183] FX This work was supported by the European Research Council (Advanced Research Grant 2014-2019; agreement #340918) granted to MAM-G and the Spanish National Health Institute of Health Carlos III (ISCIII), through CIBEROBN and "Fondo de Investigacion para la Salud" (FIS), which is co-funded by the European Regional Development Fund (six coordinated FIS projects led by JS-S and JVi, including the following projects: PI13/00673, PI13/00492, PI13/00272, PI13/01123, PI13/00462, PI13/00233, PI13/02184, PI13/00728, PI13/01090, PI13/01056, PI14/01722, PI14/00636, PI14/00618, PI14/00696, PI14/01206, PI14/01919, PI14/00853, PI14/01374, PI14/00972, PI14/00728, PI14/01471, PI16/00473, PI16/00662, PI16/01873, PI16/01094, PI16/00501, PI16/00533, PI16/00381, PI16/00366, PI16/01522, PI16/01120, PI17/00764, PI17/01183, PI17/00855, PI17/01347, PI17/00525, PI17/01827, PI17/00532, PI17/00215, PI17/01441, PI17/00508, PI17/01732, PI17/00926, PI19/00957, PI19/00386, PI19/00309, PI19/01032, PI19/00576, PI19/00017, PI19/01226, PI19/00781, PI19/01560, PI19/01332, PI20/01802, PI20/00138, PI20/01532, PI20/00456, PI20/00339, PI20/00557, PI20/00886, PI20/01158, PI21/00465); the Especial Action Project entitled: Implementacion y evaluacion de una intervencion intensiva sobre la actividad fisica Cohorte PREDIMED-Plus grant to JS-S; the Recercaixa (number 2013ACUP00194) grant to JS-S; grants from the Consejeria de Salud de la Junta de Andalucia (PI0458/2013, PS0358/2016, PI0137/2018, RH-0024-2021); the PROMETEO/2017/017 grant from the Generalitat Valenciana; and the SEMERGEN grant; Juan de la Cierva-Incorporacion research grant (IJC2019-042420-I) of the Spanish Ministry of Economy, Industry and Competitiveness and European Social Funds to JK; Miguel Servet Tipo 2 research grant (CPII20/00014) of the Spanish National Health Institute of Health Carlos III (ISCIII) to MRBL This work was also partially supported by ICREA under the ICREA Academia programme. None of the funding sources took part in the design, collection, analysis, interpretation of the data, or writing the report, or in the decision to submit the manuscript for publication. 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Nutrients PD OCT PY 2022 VL 14 IS 19 AR 4142 DI 10.3390/nu14194142 PG 21 WC Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Nutrition & Dietetics GA 5G8JQ UT WOS:000867238800001 PM 36235794 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Mirizzi, A Franco, I Leone, CM Bonfiglio, C Cozzolongo, R Notarnicola, M Giannuzzi, V Tutino, V De Nunzio, V Bruno, I Buongiorno, C Campanella, A Deflorio, V Pascale, A Procino, F Sorino, P Osella, AR AF Mirizzi, Antonella Franco, Isabella Leone, Carla Maria Bonfiglio, Caterina Cozzolongo, Raffaele Notarnicola, Maria Giannuzzi, Vito Tutino, Valeria De Nunzio, Valentina Bruno, Irene Buongiorno, Claudia Campanella, Angelo Deflorio, Valentina Pascale, Annamaria Procino, Filippo Sorino, Paolo Osella, Alberto Ruben TI Effects of Some Food Components on Non-Alcoholic Fatty Liver Disease Severity: Results from a Cross-Sectional Study SO NUTRIENTS LA English DT Article DE NAFLD severity; foods groups components; Food Frequency Questionnaire ID CONTROLLED ATTENUATION PARAMETER; INTESTINAL MICROBIOTA; MILK; DIET; FIBROSCAN(R); POPULATION; STEATOSIS; RESIDUES; FIBROSIS; SATIETY AB Background: The high prevalence of non-alcoholic fatty liver disease (NAFLD) observed in Western countries is due to the concurrent epidemics of overweight/obesity and associated metabolic complications, both recognized risk factors. A Western dietary pattern has been associated with weight gain and obesity, and more recently with NAFLD. Methods: This is a baseline cross-sectional analysis of 136 subjects (79 males) enrolled consecutively in the NUTRIATT (NUTRItion and Ac-TiviTy) study. Study subjects had moderate or severe NAFLD diagnosed by using Fibroscan-CAP. Food Frequency Questionnaire was used to obtain information about food intake. Statistical analysis included descriptive statistics and a multivariable logistic regression model. Results: The mean age was 49.58 (+/- 10.18) with a mean BMI of 33.41 (+/- 4.74). A significant inverse relationship was revealed between winter ice-cream intake and NAFLD severity (O.R. 0.65, 95% C.I. 0.95-0.99); chickpeas intake and NAFLD severity (O.R. 0.57, 95% C.I. 0.34-0.97), and not industrial aged-cheeses type (O.R. 0.85, 95% C.I. 0.74-0.98). A statistically significant positive association also emerged between rabbit meat (O.R. 1.23, 95% C.I. 1.01-1.49), industrial type aged cheeses (O.R. 1.17, 95% C.I. 1.01-1.35), milk-based desserts (no winter ice cream) (O.R. 1.11, 95% C.I. 1.01-1.21), fats (O.R. 1.12, 95% C.I. 1.01-1.25), and NAFLD severity. Conclusion: The fresh foods from non-intensive farming and high legume intake that characterize the Mediterranean diet would seem to be beneficial for patients with NAFLD. C1 [Mirizzi, Antonella; Franco, Isabella; Leone, Carla Maria; Bonfiglio, Caterina; Bruno, Irene; Buongiorno, Claudia; Campanella, Angelo; Deflorio, Valentina; Pascale, Annamaria; Procino, Filippo; Sorino, Paolo; Osella, Alberto Ruben] S de Bellis Res Hosp, Natl Inst Gastroenterol, Lab Epidemiol & Biostat, Via Turi 27, I-70013 Castellana Grotte, Italy. [Cozzolongo, Raffaele; Giannuzzi, Vito] S de Bellis Res Hosp, Natl Inst Gastroenterol, Clin Gastroenterol Unit, Via Turi 27, I-70013 Castellana Grotte, Italy. [Notarnicola, Maria; Tutino, Valeria; De Nunzio, Valentina] S de Bellis Res Hosp, Natl Inst Gastroenterol, Lab Nutr Biochem, Via Turi 27, I-70013 Castellana Grotte, Italy. RP Osella, AR (通讯作者)，S de Bellis Res Hosp, Natl Inst Gastroenterol, Lab Epidemiol & Biostat, Via Turi 27, I-70013 Castellana Grotte, Italy. EM antonella.mirizzi@irccsdebellis.it; isabella.franco@irccsdebellis.it; carlaleone@interfree.it; catia.bonfiglio@irccsdebellis.it; raffaele.cozzolongo@irccsdebellis.it; maria.notarnicola@irccsdebellis.it; vito.giannuzzi@irccsdebellis.it; valeria.tutino@irccsdebellis.it; valentinadx@hotmail.it; irenebrunodiet@gmail.com; buongiorno.claudia@gmail.com; angelocampanella7@gmail.com; valentinadeflorio@yahoo.it; annamariapsc@hotmail.com; filippo.procino@irccsdebellis.it; paolosorino96@libero.it; arosella@irccsdebellis.it RI ; Osella, Alberto/M-6888-2014; Sorino, Paolo/JFS-3040-2023; cozzolongo, raffaele/ABH-5696-2020 OI Campanella, Angelo/0000-0002-5044-4625; Mirizzi, Antonella/0000-0003-1262-0015; , Irene/0000-0001-7051-1058; Buongiorno, Claudia/0000-0003-2689-1086; Procino, Filippo/0000-0003-2740-2547; FRANCO, ISABELLA/0000-0002-3697-0127; Osella, Alberto/0000-0003-4232-8760; Bonfiglio, Caterina/0000-0002-8650-348X; Sorino, Paolo/0000-0002-9081-2648; Leone, Carla Maria/0000-0003-0465-3781; cozzolongo, raffaele/0000-0002-8343-5864 FU Italian Ministry of Health [RC2015] FX This work was funded by a grant from the Italian Ministry of Health RC2015. 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J. J. Baumgardner, J. N. Marecki, J. C. Hennings, L. Wu, X. Shankar, K. Cleves, M. A. Gomez-Acevedo, H. Badger, T. M. TI Dietary fat source alters hepatic gene expression profile and determines the type of liver pathology in rats overfed via total enteral nutrition SO PHYSIOLOGICAL GENOMICS LA English DT Article DE nonalcoholic steatohepatitis; fatty acid; lipid peroxidation; SREBP-1c; ChREBP ID POLYUNSATURATED FAT; LIPID-PEROXIDATION; BINDING-PROTEIN; ACIDS; DISEASE; STEATOHEPATITIS; ETHANOL; MODEL; METABOLISM; OBESITY AB Ronis MJJ, Baumgardner JN, Marecki JC, Hennings L, Wu X, Shankar K, Cleves MA, Gomez-Acevedo H, Badger TM. Dietary fat source alters hepatic gene expression profile and determines the type of liver pathology in rats overfed via total enteral nutrition. Physiol Genomics 44: 1073-1089, 2012. First published September 18, 2012; doi:10.1152/physiolgenomics.00069.2012.-To determine if dietary fat composition affects the progression of nonalcoholic fatty liver disease (NAFLD), we overfed male Sprague-Dawley rats low (5%) or high (70%) fat diets with different fat sources: olive oil (OO), corn oil (CO), or echium oil (EO), with total enteral nutrition (TEN) for 21 days. Overfeeding of the 5% CO or 5% EO diets resulted in less steatosis than 5% OO (P < 0.05). Affymetrix array analysis revealed significant differences in hepatic gene expression signatures associated with greater fatty acid synthesis, ChREBP, and SREBP-1c signaling and increased fatty acid transport (P < 0.05) in the 5% OO compared with 5% CO group. The OO groups had macrosteatosis, but no evidence of oxidative stress or necrosis. The 70% CO and 70% EO groups had a mixture of micro- and macrosteatosis or only microsteatosis, respectively; increased oxidative stress; and increased necrotic injury relative to their respective 5% groups (P < 0.05). Oxidative stress and necrosis correlated with increasing peroxidizability of the accumulated triglycerides. Affymetrix array analysis comparing the 70% OO and 70% CO groups revealed increased antioxidant pathways and lower expression of genes linked to inflammation and fibrosis in the 70% OO group. A second study in which 70% OO diet was overfed for 50 days produced no evidence of progression of injury beyond simple steatosis. These data suggest that dietary fat type strongly influences the progression of NAFLD and that a Mediterranean diet high in olive oil may reduce the risk of NAFLD progressing to nonalcoholic steatohepatitis. C1 [Ronis, M. J. J.; Baumgardner, J. N.; Marecki, J. C.; Wu, X.; Shankar, K.; Cleves, M. A.; Gomez-Acevedo, H.; Badger, T. M.] Univ Arkansas Med Sci, Arkansas Childrens Nutr Ctr, Little Rock, AR 72202 USA. [Ronis, M. J. J.; Baumgardner, J. N.] Univ Arkansas Med Sci, Dept Pharmacol & Toxicol, Little Rock, AR 72202 USA. [Ronis, M. J. J.; Marecki, J. C.; Wu, X.; Shankar, K.; Cleves, M. A.; Gomez-Acevedo, H.; Badger, T. M.] Univ Arkansas Med Sci, Dept Pediat, Little Rock, AR 72202 USA. [Hennings, L.] Univ Arkansas Med Sci, Dept Pathol, Little Rock, AR 72202 USA. [Badger, T. M.] Univ Arkansas Med Sci, Dept Physiol & Biophys, Little Rock, AR 72202 USA. C3 University of Arkansas System; University of Arkansas Medical Sciences; University of Arkansas System; University of Arkansas Medical Sciences; University of Arkansas System; University of Arkansas Medical Sciences; University of Arkansas System; University of Arkansas Medical Sciences; University of Arkansas System; University of Arkansas Medical Sciences RP Ronis, MJJ (通讯作者)，Univ Arkansas Med Sci, Arkansas Childrens Nutr Ctr, 15 Childrens Way, Little Rock, AR 72202 USA. EM RonisMartinJ@uams.edu RI ; Gomez-Acevedo, Horacio/AAR-8783-2021 OI Shankar, Kartik/0000-0002-7964-9026; FU ACNC-USDA-ARS CRIS [6251-51000-005-004S] FX This research was supported in part by ACNC-USDA-ARS CRIS 6251-51000-005-004S. Website: http://ars.usda.gov. "The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript". 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Genomics PD NOV PY 2012 VL 44 IS 22 BP 1073 EP 1089 DI 10.1152/physiolgenomics.00069.2012 PG 17 WC Cell Biology; Genetics & Heredity; Physiology WE Science Citation Index Expanded (SCI-EXPANDED) SC Cell Biology; Genetics & Heredity; Physiology GA 039GI UT WOS:000311232200001 PM 22991207 DA 2026-02-02 ER PT J AU Lewis, MY Yonemori, K Ross, A Wilkens, LR Shepherd, J Cassel, K Stenger, A Rettenmeier, C Lim, U Boushey, C Le Marchand, L AF Lewis, Michelle Y. Yonemori, Kim Ross, Alison Wilkens, Lynne R. Shepherd, John Cassel, Kevin Stenger, Andrew Rettenmeier, Christoph Lim, Unhee Boushey, Carol Le Marchand, Loic TI Effect of Intermittent vs. Continuous Energy Restriction on Visceral Fat: Protocol for The Healthy Diet and Lifestyle Study 2 (HDLS2) SO NUTRIENTS LA English DT Article DE obesity; intermittent energy restriction (IER); daily energy restriction; Mediterranean diet (MED); visceral adipose tissue (VAT); metabolic health; randomized control trial (RCT); body composition; dietary behavioral intervention; metabolic dysfunction-associated fatty liver disease (MAFLD) ID WEIGHT-LOSS; MEDITERRANEAN DIET; BODY-COMPOSITION; GLYCEMIC CONTROL; OVERWEIGHT; WOMEN; OBESE; INTERVENTION; IMPROVEMENT; EXPRESSION AB Obesity in the United States and Western countries represents a major health challenge associated with an increased risk of metabolic diseases, including cardiovascular disease, hypertension, diabetes, and certain cancers. Our past work revealed a more pronounced obesity-cancer link in certain ethnic groups, motivating us to develop a tailored dietary intervention called the Healthy Diet and Lifestyle 2 (HDLS2). The study protocol is described herein for this randomized six-month trial examining the effects of intermittent energy restriction (5:2 Diet) plus the Mediterranean dietary pattern (IER + MED) on visceral adipose tissue (VAT), liver fat, and metabolic biomarkers, compared to a standard MED with daily energy restriction (DER + MED), in a diverse participant group. Using MRI and DXA scans for body composition analysis, as well as metabolic profiling, this research aims to contribute to nutritional guidelines and strategies for visceral obesity reduction. The potential benefits of IER + MED, particularly regarding VAT reduction and metabolic health improvement, could be pivotal in mitigating the obesity epidemic and its metabolic sequelae. The ongoing study will provide essential insights into the efficacy of these energy restriction approaches across varied racial/ethnic backgrounds, addressing an urgent need in nutrition and metabolic health research. Registered Trial, National Institutes of Health, ClinicalTrials.gov (NCT05132686). C1 [Lewis, Michelle Y.; Yonemori, Kim; Ross, Alison; Wilkens, Lynne R.; Shepherd, John; Cassel, Kevin; Lim, Unhee; Boushey, Carol; Le Marchand, Loic] Univ Hawaii, Canc Ctr, Populat Sci Pacific Program, Honolulu, HI 96813 USA. [Stenger, Andrew; Rettenmeier, Christoph] Univ Hawaii, John A Burns Sch Med, MRI Res Ctr, Honolulu, HI 96813 USA. C3 University of Hawaii System; Cancer Research Center of Hawaii; University of Hawaii System RP Le Marchand, L (通讯作者)，Univ Hawaii, Canc Ctr, Populat Sci Pacific Program, Honolulu, HI 96813 USA. EM loic@cc.hawaii.edu RI Lim, Unhee/AEA-8591-2022 OI Lim, Unhee/0000-0001-6221-7190; Wilkens, Lynne/0000-0001-8408-4536; , Kevin/0000-0001-6167-9959; Le Marchand, Loic/0000-0001-5013-980X; Boushey, Carol/0000-0001-7517-787X FU US National Cancer Institute; Image Processing Laboratory (VIPER) at Purdue University FX Our team extends heartfelt appreciation to the Nutrition Support Shared Resource at the University of Hawaii Cancer Center, particularly to Jean Ishida and Keala Swafford, for their invaluable assistance with the development of dietary materials, intervention initiatives, and data entry efforts. We are grateful for the expertise provided by the Biostatistics Shared Resource, which aided in data management and analysis and the creation of the randomization protocol. Special thanks to Jenna Tsuzaki, Victoria Mak, Amaya Cheng, and Kylie Uyeda for their diligent work in clinic measurement coordination and collection. Our gratitude also extends to LaVonne Takaezu, Kellie Fujimoto, and Naomi Hee for managing eligibility screenings and organizing study visits efficiently. The efforts of Wileen Mau, Thad Park, and Shelle Santoki in phlebotomy, biospecimen collection, and processing have been instrumental. We are thankful for the support provided by Shirleen Saiki and Jamie Ishii in various study activities. Our work has greatly benefited from the contributions of En Liu, Valerie Saiki, and the team at John Shepherd's Lab in conducting study measurements. The Video and Image Processing Laboratory (VIPER) at Purdue University, led by Edward Delp, deserves our acknowledgment for allowing the use of the mobile food record (mFR (TM)) and for their technical support. Lastly, we recognize Michelle Harvie (Manchester Biomedical Research Centre, UK) for her support. 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quality and mortality in the non-alcoholic fatty liver disease and advanced fibrosis populations: NHANES 2005-2018 SO FRONTIERS IN NUTRITION LA English DT Article DE dietary quality indexes; mortality; NAFLD; advanced fibrosis; NHANES ID SIMPLE NONINVASIVE INDEX; INFLAMMATORY INDEX; CARDIOVASCULAR-DISEASE; MEDITERRANEAN DIET; FRUCTOSE CONSUMPTION; INSULIN-RESISTANCE; PHYSICAL-ACTIVITY; HEART-DISEASE; CANCER RISK; WEIGHT-LOSS AB Background Nonalcoholic fatty liver disease (NAFLD) has emerged as a significant global health concern, with advanced fibrosis increasing mortality risks. Despite the abundance of dietary guidelines for managing NAFLD, the precise impact of diet quality on mortality among individuals with advanced fibrosis remains elusive. This study aims to explore the influence of five dietary quality indexes on mortality among NAFLD patients and advanced fibrosis patients.Methods This study utilized data from the National Health and Nutrition Examination Survey (NHANES) spanning from 2005 to 2018 to assess dietary quality based on the Alternate Mediterranean Diet (aMED), Healthy Eating Index-2020 (HEI-2020), Dietary Approach to Stop Hypertension (DASH), Alternate Healthy Eating Index (AHEI), and Dietary Inflammatory Index (DII). Weighted Cox proportional hazard regression models along with restricted cubic splines and subgroup analyses were employed in this study.Results The analysis encompassed 3,634 NAFLD patients. After a median follow-up of 89 months, it was found that higher scores on the aMED (HR 0.814, 95% CI 0.681-0.972), HEI-2020 (HR 0.984, 95% CI 0.972-0.997), DASH (HR 0.930, 95% CI 0.883-0.979), and AHEI (HR 0.980, 95% CI 0.966-0.995) were associated with lower mortality risks, while DII scores (HR 1.280, 95% CI 1.098-1.493) indicated an increased risk of mortality. Additionally, a nonlinear relationship was identified solely between AHEI scores and all-cause mortality in NAFLD patients. Notably, among patients with advanced fibrosis, HEI-2020 as a categorical variable (T3: HR 0.519, 95% CI 0.280-0.964), DASH as a continuous variable (continuous: HR 0.921, 95% CI 0.849-0.999), AHEI (continuous: HR 0.971, 95% CI 0.945-0.997; T2: HR 0.545, 95% CI 0.310-0.960; T3: HR 0.444, 95% CI 0.245-0.804), and DII (continuous: HR 1.311, 95% CI 1.121-1.534; T3: HR 2.772, 95% CI 1.477-5.202) exhibited significant associations with all-cause mortality. Subgroup analyses revealed an interaction between AHEI scores and sex among NAFLD patients, where higher AHEI scores correlated with lower all-cause mortality in females, but no such association was observed in males. For other dietary quality, subgroup analyses indicated that their relationships with mortality were robust.Conclusion Our study suggests that a high-quality diet could potentially mitigate mortality risk in both NAFLD and advanced fibrosis patients. C1 [Huang, Xingyong; Zhang, Xiaoyue; Hao, Xuanyu; Wang, Tingting; Wu, Peng; Shen, Lufan; Yang, Yuanyuan; Zhang, Kai] China Med Univ, Endoscop Ctr, Dept Gastroenterol, Shengjing Hosp, Shenyang, Peoples R China. [Wan, Wenyu] China Med Univ, Dept Dermatol, Key Lab Immunodermatol, Minist Educ,Hosp 1, Shenyang, Peoples R China. [Wan, Wenyu] China Med Univ, Key Lab Immunodermatol, Natl Hlth Commiss Peoples Republ China, Hosp 1, Shenyang, Peoples R China. [Wan, Wenyu] China Med Univ, Natl & Local Joint Engn Res Ctr Immunodermatol The, Hosp 1, Shenyang, Peoples R China. C3 China Medical University; China Medical University; China Medical University; China Medical University RP Zhang, K (通讯作者)，China Med Univ, Endoscop Ctr, Dept Gastroenterol, Shengjing Hosp, Shenyang, Peoples R China.; Wan, WY (通讯作者)，China Med Univ, Dept Dermatol, Key Lab Immunodermatol, Minist Educ,Hosp 1, Shenyang, Peoples R China.; Wan, WY (通讯作者)，China Med Univ, Key Lab Immunodermatol, Natl Hlth Commiss Peoples Republ China, Hosp 1, Shenyang, Peoples R China.; Wan, WY (通讯作者)，China Med Univ, Natl & Local Joint Engn Res Ctr Immunodermatol The, Hosp 1, Shenyang, Peoples R China. EM wwan111@outlook.com; zhangkaidoctor@163.com RI Wang, Tingting/AFJ-3169-2022 FU Scientific Research Fund of Liaoning Province Education Department [JYTQN 2023025]; Young and middle aged science and technology innovation talent Program [RC220482]; The 345 Talent Project FX The author(s) declare that financial support was received for the research, authorship, and/or publication of this article. This work was supported by the Scientific Research Fund of Liaoning Province Education Department (Grant No. JYTQN 2023025), Young and middle aged science and technology innovation talent Program (Grant No. RC220482), and 345 Talent Project. 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Nutr. PD JAN 23 PY 2025 VL 12 AR 1507342 DI 10.3389/fnut.2025.1507342 PG 15 WC Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Nutrition & Dietetics GA U7N8P UT WOS:001413623700001 PM 39917744 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Li, SD Duan, F Li, SL Lu, BP AF Li, Shudi Duan, Fei Li, Suling Lu, Baoping TI Administration of silymarin in NAFLD/NASH: A systematic review and meta-analysis SO ANNALS OF HEPATOLOGY LA English DT Review DE NAFLD; Energy metabolism; Liver injury; Liver histological changes; Anthropometric parameters ID FATTY LIVER-DISEASE; INSULIN-RESISTANCE; NONALCOHOLIC STEATOHEPATITIS; MEDITERRANEAN DIET; METABOLIC SYNDROME; DIABETES-MELLITUS; GLYCEMIC INDEXES; LONG-TERM; EFFICACY; SILIBININ AB Introduction and Objectives: Nonalcoholic fatty liver disease (NAFLD) is a chronic liver disease with a high prevalence worldwide and poses serious harm to human health. There is growing evidence suggesting that the administration of specific supplements or nutrients may slow NAFLD progression. Silymarin is a hepatoprotective extract of milk thistle, but its efficacy in NAFLD remains unclear. Materials and Methods: Relevant studies were searched in PubMed, Embase, the Cochrane Library, Web of Science, clinicaltrails.gov, and China National Knowledge Infrastructure and were screened according to the eligibility criteria. Data were analyzed using Revman 5.3. Continuous values and dichotomous values were pooled using the standard mean difference (SMD) and odds ratio (OR). Heterogeneity was evaluated using the Cochran's Q test (I2 statistic). A P<0.05 was considered statistically significant. Results: A total of 26 randomized controlled trials involving 2,375 patients were included in this study. Administration of silymarin significantly reduced the levels of TC (SMD[95%CI]=-0.85[-1.23, -0.47]), TG (SMD [95%CI]=-0.62[-1.14, -0.10]), LDL-C (SMD[95%CI]=-0.81[-1.31, -0.31]), FI (SMD[95%CI]=-0.59[-0.91, -0.28]) and HOMA -IR (SMD[95%CI]=-0.37[-0.77, 0.04]), and increased the level of HDL-C (SMD[95%CI]=0.46[0.03, 0.89]). In addition, silymarin attenuated liver injury as indicated by the decreased levels of ALT (SMD[95%CI] =-12.39[-19.69, -5.08]) and AST (SMD[95% CI]=-10.97[-15.51, -6.43]). The levels of fatty liver index (SMD [95%CI]=-6.64[-10.59, -2.69]) and fatty liver score (SMD[95%CI]=-0.51[-0.69, -0.33]) were also decreased. Liver histology of the intervention group revealed significantly improved hepatic steatosis (OR[95%CI]=3.25 [1.80, 5.87]). Conclusions: Silymarin can regulate energy metabolism, attenuate liver damage, and improve liver histology in NAFLD patients. However, the effects of silymarin will need to be confirmed by further research. (c) 2023 Fundaci & oacute;n Cl & iacute;nica M & eacute;dica Sur, A.C. Published by Elsevier Espa & ntilde;a, S.L.U. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/) C1 [Li, Shudi] Henan Univ Chinese Med, Clin Med Coll 2, Zhengzhou 450000, Peoples R China. [Duan, Fei; Li, Suling] Henan Univ TCM Zhengzhou, Affiliated Hosp 1, Zhengzhou 450000, Peoples R China. [Lu, Baoping] Henan Univ Chinese Med, Zhengzhou 450046, Peoples R China. C3 Henan University of Traditional Chinese Medicine; Henan University of Traditional Chinese Medicine RP Lu, BP (通讯作者)，Henan Univ Chinese Med, Zhengzhou 450046, Peoples R China. EM lbp1921@sohu.com FU National famous traditional Chinese medicine Maudxi inheritance studio construction project (China Medical Office teaching Letter) [[2018] 119]; Henan Province Chinese medicine scientific research special topic [2022ZY1167]; National Clinical Research Base of Traditional Chinese Medicine, Henan Provincial Health Commission [2021 JDZX2014] FX This study was supported by National famous traditional Chinese medicine Maudxi inheritance studio construction project (China Medical Office teaching Letter [2018] 119) , Henan Province Chinese medicine scientific research special topic (2022ZY1167) , National Clinical Research Base of Traditional Chinese Medicine, Henan Provincial Health Commission (2021 JDZX2014) . The fund was not involved in any study design, data collection, analysis and interpretation, report writing, and article submission for publication. 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Hepatol. PD MAR-APR PY 2024 VL 29 IS 2 AR 101174 DI 10.1016/j.aohep.2023.101174 EA FEB 2024 PG 12 WC Gastroenterology & Hepatology WE Science Citation Index Expanded (SCI-EXPANDED) SC Gastroenterology & Hepatology GA JD0X2 UT WOS:001171112800001 PM 38579127 OA gold DA 2026-02-02 ER PT J AU Naghizadeh, MM Osati, S Homayounfar, R Masoudi-Nejad, A AF Naghizadeh, Mohammad Mehdi Osati, Saeed Homayounfar, Reza Masoudi-Nejad, Ali TI Food co-consumption network as a new approach to dietary pattern in non-alcoholic fatty liver disease SO SCIENTIFIC REPORTS LA English DT Article ID SOFT DRINK CONSUMPTION; MEDITERRANEAN DIET; RISK; ASSOCIATION; PREVALENCE; OBESITY; STEATOSIS; FIBROSIS; VALIDITY; TEHRAN AB Dietary patterns strongly correlate with non-alcoholic fatty liver disease (NAFLD), which is a leading cause of chronic liver disease in developed societies. In this study, we introduce a new definition, the co-consumption network (CCN), which depicts the common consumption patterns of food groups through network analysis. We then examine the relationship between dietary patterns and NAFLD by analyzing this network. We selected 1500 individuals living in Tehran, Iran, cross-sectionally. They completed a food frequency questionnaire and underwent scanning via the FibroScan for liver stiffness, using the CAP score. The food items were categorized into 40 food groups. We reconstructed the CCN using the Spearman correlation-based connection. We then created healthy and unhealthy clusters using the label propagation algorithm. Participants were assigned to two clusters using the hypergeometric distribution. Finally, we classified participants into two healthy NAFLD networks, and reconstructed the gender and disease differential CCNs. We found that the sweet food group was the hub of the proposed CCN, with the largest cliques of size 5 associated with the unhealthy cluster. The unhealthy module members had a significantly higher CAP score (253.7 +/- 47.8) compared to the healthy module members (218.0 +/- 46.4) (P < 0.001). The disease differential CCN showed that in the case of NAFLD, processed meat had been co-consumed with mayonnaise and soft drinks, in contrast to the healthy participants, who had co-consumed fruits with green leafy and yellow vegetables. The CCN is a powerful method for presenting food groups, their consumption quantity, and their interactions efficiently. Moreover, it facilitates the examination of the relationship between dietary patterns and NAFLD. C1 [Naghizadeh, Mohammad Mehdi; Masoudi-Nejad, Ali] Univ Tehran, Inst Biochem & Biophys, Lab Syst Biol & Bioinformat LBB, Tehran, Iran. [Naghizadeh, Mohammad Mehdi] Fasa Univ Med Sci, Noncommunicable Dis Res Ctr, Fasa, Iran. 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GERMANY SN 2045-2322 J9 SCI REP-UK JI Sci Rep PD NOV 24 PY 2023 VL 13 IS 1 AR 20703 DI 10.1038/s41598-023-47752-y PG 12 WC Multidisciplinary Sciences WE Science Citation Index Expanded (SCI-EXPANDED) SC Science & Technology - Other Topics GA EA1I4 UT WOS:001136085000028 PM 38001137 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Petroni, ML Brodosi, L Marchignoli, F Musio, A Marchesini, G AF Petroni, Maria L. Brodosi, Lucia Marchignoli, Francesca Musio, Alessandra Marchesini, Giulio TI Moderate Alcohol Intake in Non-Alcoholic Fatty Liver Disease: To Drink or Not to Drink? SO NUTRIENTS LA English DT Review DE drinking pattern; safe alcohol intake; cardiovascular system; liver disease ID HEPATITIS-C VIRUS; METABOLIC SYNDROME; RISK-FACTORS; MEDITERRANEAN DIET; BREAST-CANCER; HEPATOCELLULAR-CARCINOMA; DECREASED PREVALENCE; INSULIN SENSITIVITY; GENERAL-POPULATION; WEIGHT-GAIN AB Nonalcoholic fatty liver disease (NAFLD) is defined by hepatic steatosis in the presence of alcohol intake within safe limits, defined by guidelines of scientific associations (usually 20 g or 2 units/day in women, 30 g or 3 units in men). The diagnosis is usually followed by medical counseling of total abstinence, in order to prevent disease progression. This policy has been challenged by epidemiological studies, suggesting that the risk of liver disease and disease progression is lower in modest drinkers than in total abstainers. We revised the literature on the effects of modest alcohol intake on disease burden. Epidemiological data may suffer from several potential biases (recall bias for retrospective analyses, difficulties in the calculation of g/day), limiting their validity. Prospective data suggest that NAFLD patients with regular alcohol intake, although within the safe thresholds, are at higher risk of liver disease progression, including hepatocellular carcinoma; a detrimental effect of modest alcohol drinking is similarly observed in liver disease of viral etiology. Alcohol intake is also a risk factor for extrahepatic cancers, particularly breast, oral, and pharyngeal cancers, with gender difference and no floor effect, which outweigh the possible beneficial effects on cardiovascular system, also derived from retrospective studies. Finally, the negative effects of the calorie content of alcohol on dietary restriction and weight loss, the pivotal intervention to reduce NAFLD burden, should be considered. In summary, the policy of counseling NAFLD patients for alcohol abstinence should be maintained. C1 [Petroni, Maria L.; Brodosi, Lucia; Marchignoli, Francesca; Musio, Alessandra; Marchesini, Giulio] Alma Mater Univ St Orsola Malpighi Hosp, Dept Med & Surg Sci, Via Massarenti 9, I-40135 Bologna, Italy. RP Petroni, ML; Marchesini, G (通讯作者)，Alma Mater Univ St Orsola Malpighi Hosp, Dept Med & Surg Sci, Via Massarenti 9, I-40135 Bologna, Italy. 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Magenes, Vittoria Carlotta Vandoni, Matteo Berardo, Clarissa Marin, Luca Bianchi, Alice Cordaro, Erika Silvestro, Giustino Simone Silvestri, Dario Pellino, Vittoria Carnevale Cereda, Cristina Zuccotti, Gianvincenzo TI Benefits of Physical Exercise as Approach to Prevention and Reversion of Non-Alcoholic Fatty Liver Disease in Children and Adolescents with Obesity SO CHILDREN-BASEL LA English DT Review DE steatosis; obesity; pediatrics; exercise; physical activity; prevention ID LIFE-STYLE INTERVENTION; BODY-MASS INDEX; INSULIN SENSITIVITY; AEROBIC EXERCISE; PEDIATRIC GASTROENTEROLOGY; ALANINE AMINOTRANSFERASE; RESISTANCE EXERCISE; MEDITERRANEAN DIET; HEPATIC STEATOSIS; METABOLIC PROFILE AB Non-alcoholic fatty liver disease (NAFLD) is an important health concern during childhood; indeed, it is the most frequent cause of chronic liver diseases in obese children. No valid pharmacological therapies for children affected by this condition are available, and the recommended treatment is lifestyle modification, usually including nutrition and exercise interventions. In this narrative review, we summarized up-to-date information on the benefits of physical exercise on NAFLD in children and adolescents with obesity. The role of exercise as non-pharmacological treatment was emphasized in order to provide recent advances on this topic for clinicians not deeply involved in the field. Several studies on obese children and adults confirm the positive role of physical activity (PA) in the treatment of NAFLD, but to date, there are no pediatric randomized clinical trials on exercise versus usual care. Among the pathogenic mechanisms involved in the PA effects on NAFLD, the main players seem to be insulin resistance and related inflammation, oxidative stress, and gut dysbiosis, but further evaluations are necessary to deeply understand whether these factors are correlated and how they synergistically act. Thus, a deeper research on this theme is needed, and it would be extremely interesting. C1 [Calcaterra, Valeria; Cordaro, Erika] Univ Pavia, Dept Internal Med, I-27100 Pavia, Italy. [Calcaterra, Valeria; Magenes, Vittoria Carlotta; Bianchi, Alice; Silvestro, Giustino Simone; Zuccotti, Gianvincenzo] Vittore Buzzi Childrens Hosp, Pediat Dept, I-20154 Milan, Italy. [Vandoni, Matteo; Pellino, Vittoria Carnevale] Univ Pavia, Dept Publ Hlth Expt Med & Forens Sci, Lab Adapted Motor Act LAMA, I-27100 Pavia, Italy. [Berardo, Clarissa; Zuccotti, Gianvincenzo] Univ Milan, Dept Biomed & Clin Sci, I-20157 Milan, Italy. [Marin, Luca; Silvestri, Dario] Asomi Coll Sci, Res Dept LJA 2021, Marsa 2080, Malta. [Marin, Luca] Citta Pavia Hosp, Dept Rehabil, I-27100 Pavia, Italy. [Pellino, Vittoria Carnevale] Univ Tor Vergata Rome, Dept Ind Engn, I-00133 Rome, Italy. [Cereda, Cristina] V Buzzi Childrens Hosp, Neonatal Screening & Metab Disorders Unit, I-20154 Milan, Italy. C3 University of Pavia; University of Pavia; University of Milan; University of Rome Tor Vergata RP Marin, L (通讯作者)，Asomi Coll Sci, Res Dept LJA 2021, Marsa 2080, Malta.; Marin, L (通讯作者)，Citta Pavia Hosp, Dept Rehabil, I-27100 Pavia, Italy. 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Xin Wang, Ao Hu, Junfang LI, Li Liu, Yan TI Inhibition of neuropilin-1 improves non-alcoholic fatty liver disease in high-fat-diet induced obese mouse SO MINERVA ENDOCRINOLOGY LA English DT Article DE KEY woRDs; Neuropilin-1; Non-alcoholic fatty liver disease; Obesity; Inflammation; Phosphatidylinositol 3-kinase; TOR serine-threonine kinases ID HEPATOCELLULAR-CARCINOMA; MEDITERRANEAN DIET; CELLS; RECEPTOR; GROWTH; PATHOGENESIS; METASTASIS; STEATOSIS; APOPTOSIS; INVASION AB BACKGROUND: Research findings indicate that neuropilin-1 plays a critical role in lipid metabolism and obesity-associated insulin resistance; on such a basis, the aim of this study was to explore the effects and working mechanism of neuropilin-1 inhibition on the non-alcoholic fatty liver (NAFLD) disease in high-fat-diet (HFD) induced obese mice. METHODS: Firstly, the pcDNA3.1-NRP-1 recombinant plasmid containing neuropilin-1 (NRP1) gene and NRP1 RNA in-terference plasmid shRNA-NRP1 were successfully constructed. A total of 36 C57BL/6 mice were randomly assigned to 6 groups, blank group, control group, pcDNA3.1 injection group, pcDNA3.1-NRP-1 injection group, pGenesil-1.1 injection group and shRNA-NRP1 injection group. Expression of phospho-PI3K, phospho-AKT, phospho-mTOR and neuropilin-1 in liver was measured as well as body and liver weight, blood glucose, serum transaminases and lipid levels of the mice. RESULTS: The weight and liver mass of HFD fed mice injected with pcDNA3.1-NRP-1 were significantly higher than those from the control group, but their body weight and liver mass decreased significantly after shRNA-NRP1 injection. The results also showed that neuropilin-1 expression can significantly influence the severity of hepatic steatosis in HFD fed mice, decreased serum FPG, LDL, AST, ALT levels and the expression of tumor necrosis factor-a (TNF-a), interleukin-1p (IL -1p), and IL-6 mRNA. In addition, the Neuropilin-1 expression will also influence the p-PI3K, p-AKT and p-mTOR in mice. CONCLUSIONS: This study concluded that the inhibition of neuropilin-1 could improve NAFLD disease by decreas-ing body weight and reduce inflammation in HFD induced obese mice by modulating the PI3K/AKT/mTOR signaling pathway. C1 [Zhou, Jian; Wang, Ao] Wuhan Univ Sci & Technol, Puren Hosp, Dept Infect Dis, Wuhan, Peoples R China. [Xu, Sian; Zhu, Yue; LI, Xin; Liu, Yan] Wuhan Univ Sci & Technol, Puren Hosp, Biol Cell Therapy Res Ctr, Wuhan, Peoples R China. [Hu, Junfang] Wuhan Univ Sci & Technol, Puren Hosp, Dept Pharm, Wuhan, Peoples R China. [LI, Li] Wuhan Univ Sci & Technol, Puren Hosp, Dept Pathol, Wuhan, Peoples R China. [Liu, Yan] Wuhan Univ Sci & Technol, Puren Hosp, Biol Cell Therapy Res Ctr, Benxi Rd 1, Wuhan 430081, Peoples R China. C3 Wuhan University of Science & Technology; Wuhan University of Science & Technology; Wuhan University of Science & Technology; Wuhan University of Science & Technology; Wuhan University of Science & Technology RP Liu, Y (通讯作者)，Wuhan Univ Sci & Technol, Puren Hosp, Biol Cell Therapy Res Ctr, Benxi Rd 1, Wuhan 430081, Peoples R China. 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PD JUN PY 2023 VL 48 IS 2 BP 194 EP 205 DI 10.23736/S2724-6507.22.03895-7 PG 12 WC Endocrinology & Metabolism WE Science Citation Index Expanded (SCI-EXPANDED) SC Endocrinology & Metabolism GA H9VP4 UT WOS:000999358800008 PM 36285747 OA hybrid DA 2026-02-02 ER PT J AU Bacil, GP Romualdo, GR Rodrigues, J Barbisan, LF AF Bacil, Gabriel P. Romualdo, Guilherme R. Rodrigues, Josias Barbisan, Luis F. TI Indole-3-carbinol and chlorogenic acid combination modulates gut microbiome and attenuates nonalcoholic steatohepatitis in a murine model SO FOOD RESEARCH INTERNATIONAL LA English DT Article DE Nonalcoholic fatty liver disease; Nonalcoholic steatohepatitis; Brassicaceae vegetables; Chlorogenic acid; indole-3-carbinol ID HEPATIC STELLATE CELLS; FATTY LIVER-DISEASE; MEDITERRANEAN DIET; PHENOLIC-COMPOUNDS; IN-VIVO; STEATOSIS; SEVERITY; APOPTOSIS; PROTECTS; PATHWAY AB Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide, affecting almost 32% of the population and ranging from simple steatosis to nonalcoholic steatohepatitis (NASH). Recent findings indicate that the fast-growing prevalence of NAFLD might be linked to adherence to a Westernized diet (WD), mostly composed of fat/sugar-enriched foods. The WD has been reportedly targeted as a potential driver of gut liver axis unbalance, suggesting a major role in NASH. On the other hand, bioactive food compounds feature as a potential chemopreventive strategy against NASH, due to their beneficial effects (i.e, anti-inflammatory/oxidant activity and modulation of gut microbiome). Brassicaceae vegetables are known for their high amount of isothiocyanates and polyphenols, as indole-3-carbinol (I3C) and chlorogenic acid (CGA). Thus, we sought to assess the effects of human relevant doses of I3C and CGA isolated or in combination (5/125 mg/Kg of body weight, respectively) on a diet/chemical-induced murine model of NASH. I3C + CGA oral treatment diminished NAFLD activity score (NAS) (p < 0.0001), as well as alleviated the hepatic lipid (p = 0.0011) accumulation, prevented hepatic stellate cell (HSC) activation (p < 0.0001), and subsequent fibrosis (p < 0.0001). The combination also reduced the number of both hepatic CD68-positive macrophages (p < 0.0001) and cleaved caspase-3 hepatocytes (p < 0.0001) and diminished the malondialdehyde levels (p = 0.0155). Additionally, the combination of I3C + CGA restored the relative abundance of Alistipes (p = 0.0299), Allobaculum (p = 0.0014), Bacteroides (p = 0.0046), and Odoribacter (p = 0.0030) bacteria genera on the gut microbiome. Taken together, these findings show that the combination of I3C + CGA at populational-relevant ingestion, rather than the I3C or CGA alone, was able to modulate gut microbiome and attenuate NASH in this hybrid model mouse. C1 [Bacil, Gabriel P.] Sao Paulo State Univ UNESP, Botucatu Med Sch, Dept Pathol, Botucatu, SP, Brazil. [Romualdo, Guilherme R.; Barbisan, Luis F.] Sao Paulo State Univ UNESP, Botucatu Med Sch, Expt Res Unit UNIPEX, Multimodel Drug Screening Platform Lab Chem induce, Botucatu, SP, Brazil. [Romualdo, Guilherme R.; Barbisan, Luis F.] Sao Paulo State Univ UNESP, Biosci Inst, Dept Struct & Funct Biol, Lab Chem Induced & Expt Carcinogenesis LCQE, Botucatu, SP, Brazil. [Rodrigues, Josias] Sao Paulo State Univ UNESP, Biosci Inst, Dept Chem & Biol Sci, Lab Microbiome & Bacterian Genom LMGB, Botucatu, Brazil. [Barbisan, Luis F.] Dept Struct & Funct Biol, St Prof Dr Antonio Celso Wagner Zanin 250, BR-18618689 Botucatu, SP, Brazil. C3 Universidade Estadual Paulista; Universidade Estadual Paulista; Universidade Estadual Paulista; Universidade Estadual Paulista RP Barbisan, LF (通讯作者)，Dept Struct & Funct Biol, St Prof Dr Antonio Celso Wagner Zanin 250, BR-18618689 Botucatu, SP, Brazil. EM luis.barbisan@unesp.br RI Barbisan, Luis/AAX-8402-2021; Prata Bacil, Gabriel/AFT-5724-2022; Ribeiro Romualdo, Guilherme/AAB-4306-2020; Roigues, Josias/C-6109-2012 OI Prata Bacil, Gabriel/0000-0003-3840-7749; Ribeiro Romualdo, Guilherme/0000-0001-5320-8380; Roigues, Josias/0000-0001-8480-672X FU Sao Paulo Research Foundation (FAPESP) [2020/01944-6]; Coordination of Superior Level Staff Improvement (CAPES) [88887.481152/2020-00]; FAPESP [2020/01078-7, 2020/00377-0, 2018/16972-5]; Vinnova [2020-00377, 2020-01944] Funding Source: Vinnova FX Gabriel P. Bacil was a recipient of financial support funded by Sao Paulo Research Foundation (FAPESP) (#2020/01944-6) and Coordination of Superior Level Staff Improvement (CAPES) (88887.481152/2020-00) . Guilherme R. Romualdo received financial support from FAPESP (#2020/00377-0) . Josias Rodrigues received financial support from FAPESP (2018/16972-5) . Luis Fernando Barbisan received a grant from FAPESP (#2020/01078-7) . 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Int. PD DEC PY 2023 VL 174 AR 113513 DI 10.1016/j.foodres.2023.113513 EA OCT 2023 PN 1 PG 11 WC Food Science & Technology WE Science Citation Index Expanded (SCI-EXPANDED) SC Food Science & Technology GA W5OB5 UT WOS:001092107700001 PM 37986509 DA 2026-02-02 ER PT J AU Catalano, D Trovato, GM Martines, GF Pirri, C Trovato, FM AF Catalano, Daniela Trovato, Guglielmo M. Martines, Giuseppe Fabio Pirri, Clara Trovato, Francesca M. TI Renal function and severity of bright liver. Relationship with insulin resistance, intrarenal resistive index, and glomerular filtration rate SO HEPATOLOGY INTERNATIONAL LA English DT Article DE Bright liver; NAFLD; Renal resistive index; Obesity; Glomerular filtration rate; Insulin resistance ID CHRONIC KIDNEY-DISEASE; OBESITY; RISK; HYPERFILTRATION; HEMODYNAMICS; ASSOCIATION; VARIABILITY; OVERWEIGHT AB Aims Relationships of renal function and liver disease are described in acute and chronic liver failure. The aim of the study is to investigate which relationship, if any, is present between severity of non-alcoholic fatty liver disease (NAFLD), assessed by bright liver score (BLS) versus mild-moderate renal insufficiency assessed by glomerular filtration rate (GFR) and by ultrasound intra-renal arterial resistive index (RRI). Moreover, which difference, if any, can be found in NAFLD patients with normal versus increased transaminases. Patients The study enrolled 323 NAFLD and 176 non-NAFLD consecutive patients, comparable for age, gender distribution, GFR, and RRI referred to a university clinical day hospital after an ultrasound diagnosis of bright liver, for clinical-nutritional counselling. Personalized computerized mediterranean diet, physical activity increase, and smoking withdrawal integrated counselling were provided. Results In NAFLD patients, homoeostasis model (HOMA) has a significant correlation with BLS. According to the severity of BLS, grade II-III versus grade I patients have significantly higher values of HOMA, body mass index (BMI), triglycerides, and longitudinal right liver length. By odds ratio, more severe BLS, increased HOMA, and transaminases are associated with lower GFR. Increased transaminases are associated with higher grades of BLS, HOMA, and BMI. By multiple linear regression waist-to-hip ratio, RRI, and BLS, as significant independent factors (p < 0.0001), explain significantly variance to GFR. This is not observed in normal control group, in which only RRI is a factor explaining GFR. Conclusion Greater RRI, abdominal obesity, and greater BLS account for a lower GFR in NAFLD patients suggesting the hypothesis that inter-related factors can be operating early in the natural history of obesity-related kidney and liver disease. 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Int. PD SEP PY 2011 VL 5 IS 3 BP 822 EP 829 DI 10.1007/s12072-011-9254-2 PG 8 WC Gastroenterology & Hepatology WE Science Citation Index Expanded (SCI-EXPANDED) SC Gastroenterology & Hepatology GA 814PG UT WOS:000294468600010 PM 21484130 DA 2026-02-02 ER PT J AU Garcêz, LS Avelar, CR Fonseca, NSS Costa, PRF Lyra, AC Cunha, CM Jesus, RP Oliveira, LPM AF Garcez, Lais S. Avelar, Camila R. Fonseca, Nedja S. S. Costa, Priscila R. F. Lyra, Andre C. Cunha, Carla M. Jesus, Rosangela P. Oliveira, Lucivalda P. M. TI Effect of dietary carbohydrate and lipid modification on clinical and anthropometric parameters in nonalcoholic fatty liver disease: a systematic review and meta-analysis SO NUTRITION REVIEWS LA English DT Review DE diet; dietary intervention; nonalcoholic fatty liver disease; nonalcoholic steatohepatitis ID PHYSICAL-ACTIVITY; HEPATIC FAT; WEIGHT-LOSS; MEDITERRANEAN DIET; OBESE WOMEN; OLIVE OIL; EXERCISE; STEATOHEPATITIS; INTERVENTIONS; EPIDEMIOLOGY AB Context: Nonalcoholic fatty liver disease (NAFLD) is estimated to affect approximately 25% of the adult population, making it one of the most common chronic liver diseases worldwide and a major public health problem. Still, there is no consensus on the most appropriate nutritional intervention for disease treatment. Objective: To systematize and synthesize the results of randomized controlled trials that have evaluated the effect of dietary interventions with different, quantitative, macronutrient compositions on hepatic steatosis attenuation, serum levels of alanine aminotransferase, aspartate aminotransferase, lipid profile, glucose metabolism markers, and anthropometric parameters of adults and the elderly (age >= 60 years) with NAFLD. Data Sources: MEDLINE databases via PubMed, Embase, Science Direct, LILACS, Web of Science, ClinicalTrials.gov, and Cochrane Library were searched. Randomized controlled trials that compared interventions as diets with values <= 45% or 20% of the total daily energy intake from carbohydrates or lipids, respectively, compared with dietary reference intakes, were included. Data Extraction: Risk of bias was assessed through the Cochrane Collaboration tool. The meta-analysis was only performed to evaluate the effect of carbohydrate-modified diets on the outcome variables. The number of participants and mean values and respective standard deviations of the outcome variables were extracted and used to calculate weighted mean differences and their respective 95% CIs. Results: The search strategy resulted in 21146 studies, of which 10 were retained for qualitative analysis and 6 were included in the meta-analysis. From the analysis of 10 studies were identified 8 articles in which low-calorie diets were evaluated and 3 interventions that used an isocaloric diet. Only 3 studies were classified as having low risk of bias. Conclusion: The observed effects on hepatic steatosis, serum alanine aminotransferase and aspartate aminotransferase levels, parameters of lipid and glucose metabolism, and anthropometric variables were mostly related to a hypocaloric diet. The use of reduced macronutrient interventions had no efficacy. C1 [Garcez, Lais S.; Avelar, Camila R.; Costa, Priscila R. F.; Cunha, Carla M.; Jesus, Rosangela P.; Oliveira, Lucivalda P. M.] Univ Fed Bahia, Food Nutr & Hlth Postgrad Programme, Salvador, BA, Brazil. [Fonseca, Nedja S. S.] Univ Fed Bahia, Sci Nutr Dept, Salvador, BA, Brazil. [Lyra, Andre C.] Univ Fed Bahia, Prof Edgard Santos Univ Hosp, Gastrohepatol Serv, Salvador, BA, Brazil. C3 Universidade Federal da Bahia; Universidade Federal da Bahia; Universidade Federal da Bahia RP Garcêz, LS (通讯作者)，Univ Fed Bahia, Food Nutr & Hlth Postgrad Programme, Salvador, BA, Brazil. 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Rev. PD DEC PY 2021 VL 79 IS 12 BP 1321 EP 1337 DI 10.1093/nutrit/nuaa146 EA JAN 2021 PG 17 WC Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Nutrition & Dietetics GA XL8IL UT WOS:000728384800003 PM 33515021 DA 2026-02-02 ER PT J AU Cantero, I Abete, I Babio, N Arós, F Corella, D Estruch, R Fitó, M Hebert, JR Martínez-González, MA Pintó, X Portillo, MP Ruiz-Canela, M Shivappa, N Wärnberg, J Gómez-Gracia, E Tur, JA Salas-Salvadó, J Zulet, MA Martínez, JA AF Cantero, Irene Abete, Itziar Babio, Nancy Aros, Fernando Corella, Dolores Estruch, Ramon Fito, Montse Hebert, James R. Angel Martinez-Gonzalez, M. Pinto, Xavier Puy Portillo, M. Ruiz-Canela, Miguel Shivappa, Nitin Warnberg, Julia Gomez-Gracia, Enrique Tur, J. Antoni Salas-Salvado, Jordi Angeles Zulet, M. Alfredo Martinez, J. TI Dietary Inflammatory Index and liver status in subjects with different adiposity levels within the PREDIMED trial SO CLINICAL NUTRITION LA English DT Article DE Liver; Diet; Inflammation; NAFLD; Obesity ID FATTY LIVER; CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; HEPATOCELLULAR-CARCINOMA; SYSTEMIC INFLAMMATION; ASSOCIATION; RISK; QUESTIONNAIRE; CONSUMPTION; POPULATION AB Background & aims: To assess the possible association between a validated Dietary Inflammatory Index (DII) and specific dietary components with suitable non-invasive markers of liver status in overweight and obese subjects within the PREDIMED study. Methods: A cross-sectional study encompassing 794 randomized overweight and obese participants (mean +/- SD age: 67.0 +/- 5.0 y, 55% females) from the PREDIMED (PREvencion con Dleta MEDiterranea) trial was conducted. DII is a validated tool evaluating the effect of diet on six inflammatory biomarkers (IL-1b, IL-4, IL-6, IL-10, TNF-alpha and C-reactive protein). Furthermore, a validated 137-item food-frequency-questionnaire was used to obtain the information about the food intake. In addition, anthropometric measurements and several non-invasive markers of liver status were assessed and the Fatty Liver Index (FLI) score was calculated. Results: A higher DII and lower adherence to Mediterranean diet (MeDiet) were associated with a higher degree of liver damage (FLI > 60) in obese as compared to overweight participants. Furthermore, the DII score was positively associated with relevant non-invasive liver markers (ALT, AST, GGT and FLI) and directly affected FLI values. Interestingly, a positive correlation was observed between liver damage (>50th percentile FLI) and nutrients and foods linked to a pro-inflammatory dietary pattern. Conclusions: This study reinforced the concept that obesity is associated with liver damage and revealed that the consumption of a pro-inflammatory dietary pattern might contribute to obesity and fatty liver disease features. These data suggest that a well-designed precision diet including putative anti-inflammatory components could specifically prevent and ameliorate non-alcoholic fatty liver manifestations in addition to obesity. (C) 2017 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved. C1 [Cantero, Irene; Abete, Itziar] Univ Navarra, Ctr Nutr Res CIN, Dept Nutr Food Sci & Physiol, Pamplona, Spain. [Angeles Zulet, M.; Alfredo Martinez, J.] Navarra Inst Hlth Res IdiSNA, Ctr Nutr Res CIN, Dept Nutr Food Sci & Physiol, Pamplona, Spain. [Babio, Nancy; Aros, Fernando; Corella, Dolores; Estruch, Ramon; Fito, Montse; Angel Martinez-Gonzalez, M.; Pinto, Xavier; Puy Portillo, M.; Ruiz-Canela, Miguel; Warnberg, Julia; Tur, J. Antoni; Salas-Salvado, Jordi; Angeles Zulet, M.; Alfredo Martinez, J.] Inst Hlth Carlos III, Ctr Biomed Res Physiopathol Obes & Nutr CIBEROBN, Madrid, Spain. [Babio, Nancy; Salas-Salvado, Jordi] Univ Rovira & Virgili, Inst Invest Sanitaria Pere Virgili, Hosp Univ St Joan, Human Nutr Dept, Tarragona, Spain. [Aros, Fernando; Puy Portillo, M.] Univ Hosp Araba, Dept Cardiol, Vitoria, Spain. [Corella, Dolores] Univ Valencia, Dept Prevent Med, Valencia, Spain. [Estruch, Ramon] Univ Barcelona, Hosp Clin, Inst Invest Biomed August Pi I Sunyer, Dept Internal Med, Barcelona, Spain. [Fito, Montse] Inst Recerca Hosp del Mar, Cardiovasc & Nutr Res Grp, Barcelona, Spain. [Hebert, James R.; Shivappa, Nitin] Univ South Carolina, Canc Prevent & Control Program, Columbia, SC 29208 USA. [Angel Martinez-Gonzalez, M.; Ruiz-Canela, Miguel] Univ Navarra, Navarra Inst Hlth Res, Dept Med Prevent & Salud Publ, Pamplona, Spain. [Pinto, Xavier] Hosp Univ Bellvitge IDIBELL UB, Internal Med, Lipids & Vasc Risk Unit, Lhospitalet De Llobregat, Spain. [Warnberg, Julia; Gomez-Gracia, Enrique] Univ Malaga, Dept Prevent Med, Malaga, Spain. [Tur, J. Antoni] Univ Illes Balears, Res Grp Community Nutr & Oxidat Stress, Palma De Mallorca, Spain. C3 University of Navarra; University of Navarra; CIBER - Centro de Investigacion Biomedica en Red; CIBEROBN; Universitat Rovira i Virgili; Institut d'Investigacio Sanitaria Pere Virgili (IISPV); University Hospital of Araba; University of Valencia; University of Barcelona; Hospital Clinic de Barcelona; IDIBAPS; Hospital del Mar Research Institute; Hospital del Mar; University of South Carolina System; University of South Carolina Columbia; University of Navarra; Institut d'Investigacio Biomedica de Bellvitge (IDIBELL); Bellvitge University Hospital; Universidad de Malaga; Universitat de les Illes Balears RP Zulet, MA (通讯作者)，Univ Navarra, Dept Nutr Food Sci & Physiol, Ctr Nutr Res, Irunlarrea 1, Pamplona 31008, Spain. EM mazulet@unav.es RI PORTILLO BAQUEDANO, MARIA PUY/ABH-2374-2020; Ruiz-Canela, Miguel/JYP-1794-2024; Salas-Salvadó, Jordi/C-7229-2017; Pintó Sala, Xavier/AGI-4297-2022; Martinez-Gonzalez, Miguel/AAE-7669-2019; Estruch, Ramon/AAZ-3723-2020; Corella, Dolores/L-9888-2014; Hebert, James/IUO-5628-2023; Zulet, M./H-1317-2017; Shivappa, Nitin/X-2215-2018; BABIO SÁNCHEZ, NANCY/AAN-2715-2020; Warnberg, Julia/G-1390-2011; Tur, Josep/AAE-5748-2020; Fitó Colomer, Montse/C-1822-2012 OI PORTILLO BAQUEDANO, MARIA PUY/0000-0003-2290-592X; Ruiz-Canela, Miguel/0000-0002-7684-2787; Salas-Salvadó, Jordi/0000-0003-2700-7459; Pintó Sala, Xavier/0000-0002-2216-2444; BABIO SÁNCHEZ, NANCY/0000-0003-3527-5277; Warnberg, Julia/0000-0002-8408-316X; Gómez Gracia, Enrique/0000-0002-1281-5798; Fitó Colomer, Montse/0000-0002-1817-483X FU Instituto de Salud Carlos III (ISCIII) [RETIC G03/140]; CIBERobn; RETIC [RD 06/0045]; Centre for Nutrition Research of the University of Navarra FX The PREDIMED trial was supported by the Instituto de Salud Carlos III (ISCIII): RETIC G03/140 (to R. E.), CIBERobn and RETIC RD 06/0045 (to M. A. M. -G.). ICG holds a grant from the Centre for Nutrition Research of the University of Navarra. 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Nutr. PD OCT PY 2018 VL 37 IS 5 BP 1736 EP 1743 DI 10.1016/j.clnu.2017.06.027 PG 8 WC Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Nutrition & Dietetics GA GX2VR UT WOS:000447578700041 PM 28734553 OA Green Submitted DA 2026-02-02 ER PT J AU Mirabelli, M Chiefari, E Arcidiacono, B Corigliano, DM Brunetti, FS Maggisano, V Russo, D Foti, DP Brunetti, A AF Mirabelli, Maria Chiefari, Eusebio Arcidiacono, Biagio Corigliano, Domenica Maria Brunetti, Francesco Saverio Maggisano, Valentina Russo, Diego Foti, Daniela Patrizia Brunetti, Antonio TI Mediterranean Diet Nutrients to Turn the Tide against Insulin Resistance and Related Diseases SO NUTRIENTS LA English DT Review DE Mediterranean diet; insulin resistance; nutraceuticals; extra-virgin olive oil; HMGA1 ID FATTY LIVER-DISEASE; POLYCYSTIC-OVARY-SYNDROME; CORONARY-HEART-DISEASE; VIRGIN OLIVE OIL; TYPE-2 DIABETES-MELLITUS; ACTIVATED RECEPTOR-GAMMA; LOW-DENSITY-LIPOPROTEIN; BREAST-CANCER RISK; SUPPLEMENTATION IMPROVES MEMORY; HIGH-CARDIOVASCULAR-RISK AB Insulin resistance (IR), defined as an attenuated biological response to circulating insulin, is a fundamental defect in obesity and type 2 diabetes (T2D), and is also linked to a wide spectrum of pathological conditions, such as non-alcoholic fatty liver disease (NAFLD), cognitive impairment, endothelial dysfunction, chronic kidney disease (CKD), polycystic ovary syndrome (PCOS), and some endocrine tumors, including breast cancer. In obesity, the unbalanced production of pro- and anti-inflammatory adipocytokines can lead to the development of IR and its related metabolic complications, which are potentially reversible through weight-loss programs. The Mediterranean diet (MedDiet), characterized by high consumption of extra-virgin olive oil (EVOO), nuts, red wine, vegetables and other polyphenol-rich elements, has proved to be associated with greater improvement of IR in obese individuals, when compared to other nutritional interventions. Also, recent studies in either experimental animal models or in humans, have shown encouraging results for insulin-sensitizing nutritional supplements derived from MedDiet food sources in the modulation of pathognomonic traits of certain IR-related conditions, including polyunsaturated fatty acids from olive oil and seeds, anthocyanins from purple vegetables and fruits, resveratrol from grapes, and the EVOO-derived, oleacein. Although the pharmacological properties and clinical uses of these functional nutrients are still under investigation, the molecular mechanism(s) underlying the metabolic benefits appear to be compound-specific and, in some cases, point to a role in gene expression through an involvement of the nuclear high-mobility group A1 (HMGA1) protein. C1 [Mirabelli, Maria; Chiefari, Eusebio; Arcidiacono, Biagio; Corigliano, Domenica Maria; Brunetti, Francesco Saverio; Maggisano, Valentina; Russo, Diego; Foti, Daniela Patrizia; Brunetti, Antonio] Magna Graecia Univ Catanzaro, Dept Hlth Sci, I-88100 Catanzaro, Italy. C3 Magna Graecia University of Catanzaro RP Brunetti, A (通讯作者)，Magna Graecia Univ Catanzaro, Dept Hlth Sci, I-88100 Catanzaro, Italy. EM maria.mirabelli@unicz.it; echiefari@gmail.com; arcidiacono@unicz.it; domenicacorigliano@gmail.com; francescosaverio.brunetti@studenti.unicz.it; vmaggisano@unicz.it; d.russo@unicz.it; foti@unicz.it; brunetti@unicz.it RI Chiefari, Eusebio/Y-2558-2019; Mirabelli, Maria/AAO-4757-2021; Brunetti, Antonio/K-7756-2016; Foti, Daniela/K-8038-2016 OI Chiefari, Eusebio/0000-0001-5329-3124; Mirabelli, Maria/0000-0002-6427-7186; Russo, Diego/0000-0001-7559-1595; Brunetti, Antonio/0000-0003-1533-8779; Foti, Daniela/0000-0002-9536-5736 FU European Commission; FESR FSE 2014-2020; Regione Calabria FX This publication is co-financed with the support of the European Commission, FESR FSE 2014-2020 and Regione Calabria. The European Commission and Regione Calabria's supports for the production of this publication do not constitute an endorsement of the contents, which reflect the views only of the authors, and cannot be held responsible for any use which may be made of the information contained therein. 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ADVANCED FIBROSIS; GUT MICROBIOME; METABOLITES; ACCUMULATION; FRACTION; LIGNANS; NAFLD AB Background: Non-alcoholic fatty liver disease (NAFLD) has become a growing public health problem worldwide, and dietary interventions have important potential in the prevention and treatment of NAFLD. Moreover, previous animal studies have shown that flaxseed has a good improvement effect in animal NAFLD models. Objectives: Assess whether flaxseed powder could improve the liver lipid content in patients with NAFLD. Methods: In this 12-week randomized controlled clinical trial, 50 patients were randomly assigned to the flaxseed group (n = 25) and the control group (n = 25). The flaxseed group received 30 g d(-1) flaxseed powder orally before lunch or dinner along with health education, while the control group received only health education. The primary outcome was the intrahepatic lipid content assessed by the proton density fat fraction estimated by magnetic resonance imaging, and secondary outcomes were body composition measurements, liver function, and glucolipid metabolism. Results: Patients in the flaxseed group showed significantly lower liver fat content, body fat percentage, obesity index, visceral fat area, serum total bilirubin (TBIL), direct bilirubin (DBIL), indirect bilirubin (IBIL), aspartate aminotransferase (AST), total cholesterol (TC), and triglyceride (TG) levels after a 12-week intervention compared to pre-intervention levels, while serum apolipoprotein A1 (Apo A1) and high-density lipoprotein cholesterol (HDL-C) levels were significantly increased, with all differences being statistically significant (P < 0.05). Analysis of the gut microbiota showed that, at the phylum level, flaxseed intervention significantly increased the abundance of Bacteroides and Actinobacteria, while decreasing the ratio of Firmicutes to Bacteroidetes. At the genus level, the relative abundance of Clostridium_sensu_stricto_1, Parasutterella, Lachnospiraceae_NK4A136_group, Eubacterium_xylanophilum_group, and Bifidobacterium in the gut microbiota of the flaxseed group was significantly higher than that of the control group (P < 0.05), whereas the relative abundance of Coriobacteriaceae_UCG-002 was significantly lower than that of the control group (P < 0.05). Conclusions: Flaxseed powder intervention for 12 weeks had the effect of improving liver lipid deposition, liver function, body composition indicators, and lipid metabolism in patients with NAFLD. It also regulated the gut microbiota in NAFLD patients, increasing the abundance of beneficial bacteria while reducing harmful bacteria. This suggested that flaxseed is one of the natural and effective foods for improving NAFLD. C1 [Tian, Yanyan; Zhou, Yuhao; Liao, Wang; Xia, Jiayue; Sun, Guiju; Yang, Ligang] Southeast Univ, Key Lab Environm Med & Engn Minist Educ, Nanjing 210009, Peoples R China. [Tian, Yanyan; Zhou, Yuhao; Liao, Wang; Xia, Jiayue; Sun, Guiju; Yang, Ligang] Southeast Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Nanjing 210009, Peoples R China. [Hu, Qiaosheng; Zhao, Qing; Zhang, Rui; Li, Lihua] Nanjing Med Univ, Lianshui Peoples Hosp Affiliated, Kangda Coll, Huaian 223400, Jiangsu, Peoples R China. C3 Southeast University - China; Southeast University - China; Nanjing Medical University RP Sun, GJ; Yang, LG (通讯作者)，Southeast Univ, Key Lab Environm Med & Engn Minist Educ, Nanjing 210009, Peoples R China.; Sun, GJ; Yang, LG (通讯作者)，Southeast Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Nanjing 210009, Peoples R China.; Li, LH (通讯作者)，Nanjing Med Univ, Lianshui Peoples Hosp Affiliated, Kangda Coll, Huaian 223400, Jiangsu, Peoples R China. EM gjsun@seu.edu.cn; yangligang2012@163.com; lihua200121@126.com RI Zhou, Yuhao/AAH-4245-2019; li, lihua/MTD-8071-2025 OI JiaYue, Xia/0000-0002-0740-6877 FU National Natural Science Foundation of China [82073551]; National Natural Science Foundation of China [HABL202261]; Huai'an Natural Science Research Plan (Joint Special Project) Health Research Project; People's Hospital of Lianshui County, Huai'an City, Jiangsu Province, China FX This work was supported by the National Natural Science Foundation of China under Grant [82073551] and the Huai'an Natural Science Research Plan (Joint Special Project) Health Research Project [HABL202261]. We appreciate the valuable suggestions and assistance provided by the People's Hospital of Lianshui County, Huai'an City, Jiangsu Province, China, for this experiment. 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PD FEB 17 PY 2025 VL 16 IS 4 BP 1389 EP 1406 DI 10.1039/d4fo05847j EA JAN 2025 PG 18 WC Biochemistry & Molecular Biology; Food Science & Technology WE Science Citation Index Expanded (SCI-EXPANDED) SC Biochemistry & Molecular Biology; Food Science & Technology GA X2C9Y UT WOS:001410262100001 PM 39878023 OA hybrid DA 2026-02-02 ER PT J AU Shah, RA Alkhouri, N Kowdley, K AF Shah, Raj A. Alkhouri, Naim Kowdley, Kris, V TI Emerging drugs for the treatment of non-alcoholic steatohepatitis: a focused review of farnesoid X receptor agonists SO EXPERT OPINION ON EMERGING DRUGS LA English DT Review DE Farnesoid x receptor; obeticholic acid; NAFLD; NASH ID FATTY LIVER-DISEASE; VITAMIN-E SUPPLEMENTATION; WEIGHT-LOSS; CARDIOVASCULAR-DISEASE; PRACTICE GUIDELINES; MEDITERRANEAN DIET; OBETICHOLIC ACID; NUCLEAR RECEPTOR; GUT MICROBIOTA; BILE-ACIDS AB Introduction The discovery of the farnesoid X receptor and its role in bile and lipid homeostasis has led to the investigation of FXR agonists as a therapy in cholestatic disorders and in NAFLD. With increasing prevalence of obesity and metabolic syndrome, NAFLD has grown to become the most prevalent chronic liver disease, present in a quarter of the worldwide population. FXR agonists represent a promising avenue for this burgeoning disease with few options for pharmacologic therapy. Areas covered A brief overview of the epidemiology of NAFLD/NASH and a review of current evidence on available treatments is provided. For FXR agonists, a review is performed of mechanisms of action, efficacy, and adverse effects. Finally, hurdles to widespread adoption of this drug class in treatment of NASH are described. Prospective clinical trials were reviewed on the US National Library of Medicine database at clinicaltrials.gov, along with a literature search of meta-analyses, reviews, and original research. Expert opinion FXR agonists show promise for treating NASH with positive effects on several surrogate markers of disease including liver fibrosis on biopsy, fat reduction on MRI, and decrease in liver enzymes. However, their long-term tolerability, safety, and efficacy on liver-related outcomes need to be established. C1 [Shah, Raj A.; Kowdley, Kris, V] Liver Inst Northwest, Seattle, WA 98105 USA. [Alkhouri, Naim] Texas Liver Inst, San Antonio, TX USA. RP Kowdley, K (通讯作者)，Liver Inst Northwest, Seattle, WA 98105 USA. 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Drugs PD JUL 2 PY 2020 VL 25 IS 3 BP 251 EP 260 DI 10.1080/14728214.2020.1796968 EA AUG 2020 PG 10 WC Pharmacology & Pharmacy WE Science Citation Index Expanded (SCI-EXPANDED) SC Pharmacology & Pharmacy GA NR5TP UT WOS:000558495300001 PM 32686578 DA 2026-02-02 ER PT J AU Aktary, ML Eller, LK Nicolucci, AC Reimer, RA AF Aktary, Michelle L. Eller, Lindsay K. Nicolucci, Alissa C. Reimer, Raylene A. TI Cross-sectional analysis of the health profile and dietary intake of a sample of Canadian adults diagnosed with non-alcoholic fatty liver disease SO FOOD & NUTRITION RESEARCH LA English DT Article DE nutrients; NAFLD; steatosis; energy intake; micronutrients; obesity; metabolic syndrome ID LIFE-STYLE; CARDIOVASCULAR-DISEASE; NUTRITIONAL MANAGEMENT; MEDITERRANEAN DIET; INSULIN-RESISTANCE; METABOLIC SYNDROME; RISK-FACTORS; VITAMIN-E; FRUCTOSE; CALCIUM AB Background: Dietary intake is an important factor in the development and management of non-alcoholic fatty liver disease (NAFLD); however, optimal dietary composition remains unclear. Moreover, there is minimal evidence on the relationship between dietary intake and markers of liver health in Canadian adults diagnosed with NAFLD. Objective: The aim of this study is to characterize the dietary intake of a sample of Canadian adults diagnosed with NAFLD and examine the correlations with markers of liver health. Design: Forty-two adults recruited from the community and hepatology clinics in Calgary, Canada from 2016 to 2019 completed a 3-day food record. Anthropometrics, blood biomarkers, liver stiffness (FibroScan), and liver fat (magnetic resonance imaging) were measured. Nutrient intake was compared with the data from the 2004 and 2015 Canadian Community Health Surveys. Relationships were assessed using Pearson's correlation and regression analysis. Results: Relative to Canadian dietary recommendations, participants consumed lower magnesium, fiber, calcium, vitamin D, and vitamin F, and higher cholesterol, saturated fat, total fat, fructose, iron, vitamin B12, selenium, phosphorus, and sodium. Compared with the national average, participants consumed more energy, fiber, sodium, total fat, and saturated fat. Systolic blood pressure (P = 0.012), serum alpha-2 macroglobulin (P = 0.008), carbohydrate (P = 0.022), total fat (P = 0.029), and saturated fat intakes (P = 0.029) were associated with FibroScan scores. Liver fat was correlated with serum triglycerides (P < 0.001), trunk fat (P = 0.029), added sugar (P = 0.042), phosphorus (P = 0.017), and magnesium intake (P = 0.013). In females, selenium intake was associated with liver fat (P = 0.015) and FibroScan score (P = 0.05), while in males, liver fat was associated with trunk fat (P = 0.004), body weight (P = 0.004), high-density lipoprotein (P < 0.001), and fructose intake (P = 0.037). Regression analysis showed that increasing magnesium intake corresponds to a decrease in liver fat. Conclusion: Despite the higher energy intake of participants, overall nutrient intake is low, suggesting lower diet quality. Associations between select micronutrients and liver health markers warrant further investigation. C1 [Aktary, Michelle L.; Eller, Lindsay K.; Nicolucci, Alissa C.; Reimer, Raylene A.] Univ Calgary, Fac Kinesiol, Calgary, AB, Canada. [Reimer, Raylene A.] Univ Calgary, Dept Biochem & Mol Biol, Cumming Sch Med, Calgary, AB, Canada. C3 University of Calgary; University of Calgary RP Reimer, RA (通讯作者)，Fac Kinesiol, 2500 Univ Dr NW, Calgary, AB, Canada. EM reimer@ucalgary.ca OI Reimer, Raylene/0000-0001-5088-7947 FU Canadian Institutes for Health Research [MOP-136889] FX The authors declare no potential conflicts of interest. This work is funded by a grant held by RAR from the Canadian Institutes for Health Research (MOP-136889). 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Res. PD SEP 18 PY 2020 VL 64 AR 4548 DI 10.29219/fnr.v64.4548 PG 14 WC Food Science & Technology; Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Food Science & Technology; Nutrition & Dietetics GA NS2SE UT WOS:000572116500001 PM 33061886 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Lonardo, A Ballestri, S Targher, G Loria, P AF Lonardo, Amedeo Ballestri, Stefano Targher, Giovanni Loria, Paola TI Diagnosis and management of cardiovascular risk in nonalcoholic fatty liver disease SO EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY LA English DT Review DE cardiovascular risk; Framingham risk score; HCC; metformin; NASH; statins; steatosis ID RENIN-ANGIOTENSIN SYSTEM; TYPE-2 DIABETES-MELLITUS; CORONARY-HEART-DISEASE; TERM-FOLLOW-UP; INTRAGASTRIC BALLOON; HEPATOCELLULAR-CARCINOMA; BARIATRIC SURGERY; MEDITERRANEAN DIET; PEPTIDE-1 RECEPTOR; HEPATIC STEATOSIS AB Nonalcoholic fatty liver disease (NAFLD) is increasingly recognized as an important cardiovascular risk (CVR) factor. This is a narrative clinical review aimed at answering how diagnosis and management of CVR should be conducted in the individual patient with NAFLD. To this end, the authors performed an extensive search of the existing literature on PubMed (1993-2014) using pertinent keywords. To date, CVR among patients with NAFLD might be assessed with the Framingham risk score equation or other risk calculators, to be adapted to the true CVR in the specific population being assessed; however, the use of these CVR calculators needs to be validated by future studies in larger cohorts of NAFLD patients of various ethnic backgrounds in order to substantiate their clinical relevance as a foundation for the primary prevention of cardiovascular diseases in this group of patients. Early and aggressive drug treatment of CVR should be started in NAFLD patients with a history of cardiovascular events, established diabetes or who are at high (calculated) CVR. Whether such an aggressive pharmacological approach is also justified in patients with NAFLD, who are at intermediate or low CVR, remains debatable. Currently, there are no clinical trials showing that the treatment of NAFLD per se (either associated or unassociated with traditional CVR factors) will result in decreased risk of cardiovascular events. Accordingly, drug treatment should be better individualized, aiming at correcting all the coexisting cardio-metabolic risk factors of the individual patient with NAFLD. To this end, an overview of the lifestyle interventions and the available drugs is offered, emphasis being conveyed to statins and metformin, which promise to cover worrying complications of NAFLD such as the risk of developing hepatocellular carcinoma. C1 [Lonardo, Amedeo; Ballestri, Stefano; Loria, Paola] Pavullo Hosp, Div Internal Med, Dept Med, I-41026 Pavullo nel Frignano, Italy. [Targher, Giovanni] Univ Verona, Dept Med, Div Endocrinol Diabet & Metab, I-37126 Verona, Italy. [Targher, Giovanni] Azienda Osped Univ Integrata, I-37126 Verona, Italy. C3 University of Verona; University of Verona; Azienda Ospedaliera Universitaria Integrata Verona RP Lonardo, A (通讯作者)，Pavullo Hosp, Div Internal Med, Dept Med, I-41026 Pavullo nel Frignano, Italy. 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Gastroenterol. Hepatol. PD MAY PY 2015 VL 9 IS 5 BP 629 EP 650 DI 10.1586/17474124.2015.965143 PG 22 WC Gastroenterology & Hepatology WE Science Citation Index Expanded (SCI-EXPANDED) SC Gastroenterology & Hepatology GA CG8QH UT WOS:000353574200009 PM 25327387 DA 2026-02-02 ER PT J AU Bordignon, F Tomás-Vidal, A Trocino, A Sorribes, MMC Jover-Cerdá, M Martínez-Llorens, S AF Bordignon, Francesco Tomas-Vidal, Ana Trocino, Angela Sorribes, Maria C. Milian Jover-Cerda, Miguel Martinez-Llorens, Silvia TI Fatty Acid Signatures in Different Tissues of Mediterranean Yellowtail, Seriola dumerili (Risso, 1810), Fed Diets Containing Different Levels of Vegetable and Fish Oils SO ANIMALS LA English DT Article DE brain; muscle; liver; greater amberjack; EPA; DHA ID SALMON SALMO-SALAR; DOCOSAHEXAENOIC ACID; GROWTH-PERFORMANCE; TOTAL REPLACEMENT; LIPID-COMPOSITION; ARACHIDONIC-ACID; RAPESEED OIL; MARINE FISH; FRESH-WATER; PROSTAGLANDIN PRODUCTION AB Simple Summary Most of the studies performed to date mainly investigated on the effects of dietary substitution of fish oil with vegetable oils on growth and fatty acid composition of edible muscle tissues. On the other hand, a few assessed how dietary lipids are retained in other tissues, such as brain, liver, and adipose tissue, which would provide further insights into the fatty acid requirements of new farmed marine fish species such as Seriola dumerili. Thus, this study evaluated how the replacement of fish oil with different proportions of vegetable oils in diets affects the tissue-specific fatty acid composition (also known as signature) of brain, muscle, liver, and visceral fat of S. dumerili. The fatty acid composition of the diet had a strong effect on the fatty acid signature of muscle, liver, and visceral fat, whereas the brain signature was less sensitive to dietary changes. These new insights contribute to identify the essential fatty acids requirements of Mediterranean yellowtail and to define the conditions under which the physiological functions in these fish are preserved when they are fed diets with low fish oil levels to guarantee the sustainability of their production and welfare. The study aimed to evaluate how replacing different proportions of fish oil (FO) with vegetable oils (VO) in the diet of Mediterranean yellowtail, Seriola dumerili (Risso, 1810), affects the fatty acids (FA) signature, i.e.; overall FA profile, in different tissues. A total of 225 Mediterranean yellowtail juveniles (initial live weight: 176 +/- 3.62 g) were fed for 109 days with one of three diets: A control diet (FO 100), with FO as the only lipid source, or diets with 75% and 100% of FO replaced with a VO mixture. At the end of the feeding trial, the brains, muscles, livers, and visceral fat were sampled in four fish per tank (12 per treatment), and their fat were extracted and used for FA analysis. The FA signatures of red and white muscle, liver, and visceral fat tissues changed when the dietary FA source changed, whereas FA signatures in the brain were rather robust to such dietary changes. These new insights might help evaluate whether key physiological functions are preserved when fish are fed diets with low FO levels, as well as define the dietary FA requirements of Mediterranean yellowtail to improve the sustainability of the production and welfare of the fish. C1 [Bordignon, Francesco; Trocino, Angela] Univ Padua, Dept Comparat Biomed & Food Sci BCA, Viale Univ 16, I-35020 Legnaro, Italy. [Tomas-Vidal, Ana; Sorribes, Maria C. Milian; Jover-Cerda, Miguel; Martinez-Llorens, Silvia] Univ Politecn Valencia, Grp Aquaculture & Biodivers, Inst Anim Sci & Technol, Camino Vera 14, Valencia 46071, Spain. C3 University of Padua; Universitat Politecnica de Valencia RP Trocino, A (通讯作者)，Univ Padua, Dept Comparat Biomed & Food Sci BCA, Viale Univ 16, I-35020 Legnaro, Italy. EM francesco.bordignon.3@phd.unipd.it; atomasv@dca.upv.es; angela.trocino@unipd.it; mamisor@etsia.upv.es; mjover@dca.upv.es; silmarll@dca.upv.es RI jover, miguel/L-9558-2014; VIDAL, ANA/L-8254-2014; Bordignon, Francesco/HOH-8526-2023 OI Milián-Sorribes, Maria Consolación/0000-0002-8555-4939; Trocino, Angela/0000-0001-9045-6156; Bordignon, Francesco/0000-0002-5377-8698; MARTÍNEZ LLORENS, SILVIA/0000-0002-9824-3267 FU ECCEAQUA project (MIUR) [CUP: C26C18000030004] FX The Ph.D. grant held by Francesco Bordignon is funded by the ECCEAQUA project (MIUR; CUP: C26C18000030004). 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KW7IE UT WOS:000521356600153 PM 31991644 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Lama, A Pirozzi, C Mollica, MP Trinchese, G Di Guida, F Cavaliere, G Calignano, A Raso, GM Canani, RB Meli, R AF Lama, Adriano Pirozzi, Claudio Mollica, Maria Pia Trinchese, Giovanna Di Guida, Francesca Cavaliere, Gina Calignano, Antonio Raso, Giuseppina Mattace Canani, Roberto Berni Meli, Rosaria TI Polyphenol-rich virgin olive oil reduces insulin resistance and liver inflammation and improves mitochondrial dysfunction in high-fat diet fed rats SO MOLECULAR NUTRITION & FOOD RESEARCH LA English DT Article DE Inflammation; Mediterranean diet; Mitochondrial and hepatic oxidative stress; Nonalcoholic Fatty liver disease; Olive oil polyphenols ID RANDOMIZED CONTROLLED-TRIAL; MEDITERRANEAN DIET; OXIDATIVE STRESS; LIPID-METABOLISM; HEPATIC STEATOSIS; FED MICE; DISEASE; PATHOGENESIS; MODULATION; EXPRESSION AB Scope: Virgin olive oil is an essential component of the Mediterranean diet. Its antioxidant and anti-inflammatory properties are mainly linked to phenolic contents. This study aims to evaluate the beneficial effects of a polyphenol-rich virgin olive oil (HPCOO) or olive oil without polyphenols (WPOO) in rats fed high-fat diet (HFD). Methods and results: Male Sprague-Dawley rats were divided into four groups based on the different types of diet: (I) standard diet (STD); (II) HFD; (III) HFD containing WPOO, and (IV) HFD containing HPCOO. HPCOO and WPOO induced a significant improvement of HFD-induced impaired glucose homeostasis (by hyperglycemia, altered oral glucose tolerance, and HOMA-IR) and inflammatory status modulating pro-and anti-inflammatory cytokines (TNF-alpha, IL-1, and IL-10) and adipokines. Moreover, HPCOO and less extensively WPOO, limited HFD-induced liver oxidative and nitrosative stress and increased hepatic fatty acid oxidation. To study mitochondrial performance, oxidative capacity and energy efficiency were also evaluated in isolated liver mitochondria. HPCOO, but not WPOO, reduced H2O2 release and aconitase activity by decreasing degree of coupling, which plays a major role in the control of mitochondrial reactive oxygen species emission. Conclusion: HPCOO limits HFD-induced insulin resistance, inflammation, and hepatic oxidative stress, preventing nonalcoholic fatty liver disease progression. C1 [Lama, Adriano; Pirozzi, Claudio; Di Guida, Francesca; Calignano, Antonio; Raso, Giuseppina Mattace; Meli, Rosaria] Univ Naples Federico II, Dept Pharm, Naples, Italy. [Mollica, Maria Pia; Trinchese, Giovanna; Cavaliere, Gina] Univ Naples Federico II, Dept Biol, Naples, Italy. [Canani, Roberto Berni] Univ Naples Federico II, Dept Translat Med Sci, Naples, Italy. [Canani, Roberto Berni] Univ Naples Federico II, European Lab Invest Food Induced Dis, Naples, Italy. [Canani, Roberto Berni] Univ Naples Federico II, CEINGE Adv Biotechnol, Naples, Italy. C3 University of Naples Federico II; University of Naples Federico II; University of Naples Federico II; University of Naples Federico II; CEINGE Biotecnologie Avanzate; University of Naples Federico II RP Meli, R (通讯作者)，Univ Naples Federico II, Dept Pharm, Naples, Italy. EM meli@unina.it RI TRINCHESE, Giovanna/AAC-5995-2022; Berni Canani, Roberto/AAC-4810-2022; Calignano, Antonio/K-2542-2018; Pirozzi, Claudio/S-2760-2016; Lama, Adriano/AAC-1964-2020 OI TRINCHESE, Giovanna/0000-0002-4096-6876; Mattace Raso, Giuseppina/0000-0002-5254-139X; Mollica, Maria Pina/0000-0003-2726-7779; Berni Canani, Roberto/0000-0002-5169-9574; Meli, Rosaria/0000-0002-6246-6813; Pirozzi, Claudio/0000-0002-3409-5744; FU Italian Ministry of University and Research (MIUR) [2010JCWWKM-005] FX This study was supported by a grant from Italian Ministry of University and Research (MIUR) PRIN 2010-2011-prot. 2010JCWWKM-005, without any financial or other contractual agreements that may cause conflict of interest. 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Nutr. Food Res. PD MAR PY 2017 VL 61 IS 3 AR 1600418 DI 10.1002/mnfr.201600418 PG 12 WC Food Science & Technology WE Science Citation Index Expanded (SCI-EXPANDED) SC Food Science & Technology GA EQ5BD UT WOS:000398095000003 PM 27794174 DA 2026-02-02 ER PT J AU Mayr, HL Kostjasyn, SP Campbell, KL Palmer, M Hickman, IJ AF Mayr, Hannah L. Kostjasyn, Sarah P. Campbell, Katrina L. Palmer, Michelle Hickman, Ingrid J. TI Investigating Whether the Mediterranean Dietary Pattern Is Integrated in Routine Dietetic Practice for Management of Chronic Conditions: A National Survey of Dietitians SO NUTRIENTS LA English DT Article DE Mediterranean diet; chronic disease; online survey; dietitian; barriers and facilitators; health services research ID TYPE-2 DIABETES-MELLITUS; CARDIOVASCULAR-DISEASE; ENDOTHELIAL FUNCTION; HEPATIC STEATOSIS; INTERVENTION; STATEMENT; UPDATE; ADULTS; CARE AB Evidence supports recommending the Mediterranean dietary pattern (MDP) in the management of cardiovascular disease (CVD), type 2 diabetes (T2D), non-alcoholic fatty liver disease (NAFLD) and solid organ transplant (SOT). However, the evidence-practice gap is unclear within non-Mediterranean countries. We investigated integration of MDP in Australian dietetic practice, and barriers and enablers to MDP implementation for chronic disease management. Dietitians managing CVD, T2D, NAFLD and/or SOT patients (n = 182, 97% female) completed an online survey in November 2019. Fewer than 50% of participants counsel patients with CVD (48%), T2D (26%), NAFLD (31%) and SOT (0-33%) on MDP in majority of their practice. MDP principles always recommended by >50% of participants were promoting vegetables and fruit and limiting processed foods and sugary drinks. Principles recommended sometimes, rarely or never by >50% of participants included limiting red meat and including tomatoes, onion/garlic and liberal extra virgin olive oil. Barriers to counselling on MDP included consultation time and competing priorities. Access to evidence, professional development and education resources were identified enablers. An evidence-practice gap in Australian dietetic practice exists with <50% of participants routinely counselling relevant patient groups on MDP. Strategies to support dietitians to counsel complex patients on MDP within limited consultations are needed. C1 [Mayr, Hannah L.; Campbell, Katrina L.; Hickman, Ingrid J.] Princess Alexandra Hosp, Nutr & Dietet Dept, Brisbane, Qld 4102, Australia. [Mayr, Hannah L.; Kostjasyn, Sarah P.; Campbell, Katrina L.] Bond Univ, Fac Hlth Sci & Med, Nutr & Dietet Res Grp, Gold Coast, Qld 4226, Australia. [Mayr, Hannah L.] La Trobe Univ, Sch Allied Hlth Human Serv & Sport, Melbourne, Vic 3086, Australia. [Mayr, Hannah L.; Campbell, Katrina L.; Hickman, Ingrid J.] Univ Queensland, Fac Med, Brisbane, Qld 4072, Australia. [Palmer, Michelle] Logan Hosp, Nutr & Dietet Dept, Meadowbrook, Qld 4131, Australia. C3 Princess Alexandra Hospital; Bond University; La Trobe University; University of Queensland; Logan Hospital RP Mayr, HL (通讯作者)，Princess Alexandra Hosp, Nutr & Dietet Dept, Brisbane, Qld 4102, Australia.; Mayr, HL (通讯作者)，Bond Univ, Fac Hlth Sci & Med, Nutr & Dietet Res Grp, Gold Coast, Qld 4226, Australia.; Mayr, HL (通讯作者)，La Trobe Univ, Sch Allied Hlth Human Serv & Sport, Melbourne, Vic 3086, Australia.; Mayr, HL (通讯作者)，Univ Queensland, Fac Med, Brisbane, Qld 4072, Australia. EM hmayr@bond.edu.au; sarahkostjasyn@hotmail.com; katrina.campbell@health.qld.gov.au; michelle.palmer@health.qld.gov.au; i.hickman@uq.edu.au RI Campbell, Katrina/A-2290-2013; Hickman, Ingrid J/P-8364-2016 OI Mayr, Hannah L/0000-0001-7356-653X; Palmer, Michelle/0000-0002-6528-760X; Hickman, Ingrid J/0000-0003-3205-9165 FU Metro South Health's Study, Education and Research Trust Account (SERTA) Early Career Research Grant FX H.L.M. was supported by a Metro South Health's Study, Education and Research Trust Account (SERTA) Early Career Research Grant. 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Perng, Wei Sauder, Katherine A. Shapiro, Allison L. B. Starling, Anne P. Friedman, Chloe Felix, Janine F. Kuepers, Leanne K. Moore, Brianna F. Hebert, James R. Shivappa, Nitin Scherzinger, Ann Sundaram, Shikha S. Shankar, Kartik Dabelea, Dana TI Maternal Diet Quality During Pregnancy and Offspring Hepatic Fat in Early Childhood: The Healthy Start Study SO JOURNAL OF NUTRITION LA English DT Article DE developmental origins; diet quality; maternal-child health; fatty liver; pediatrics ID EPISODICALLY CONSUMED FOODS; INSULIN-RESISTANCE; NEONATAL ADIPOSITY; MEDITERRANEAN DIET; MEASUREMENT ERROR; BODY-COMPOSITION; LIVER-DISEASE; GLYCEMIC-LOAD; FETAL-GROWTH; RISK AB Background: Overnutrition in utero may increase offspring risk of nonalcoholic fatty liver disease (NAFLD), but the specific contribution of maternal diet quality during pregnancy to this association remains understudied in humans.Objectives: This study aimed to examine the associations of maternal diet quality during pregnancy with offspring hepatic fat in early childhood (median: 5 y old, range: 4-8 y old).Methods: Data were from 278 mother-child pairs in the longitudinal, Colorado-based Healthy Start Study. Multiple 24-h recalls were collected from mothers during pregnancy on a monthly basis (median: 3 recalls, range: 1-8 recalls starting after enrollment), and used to estimate maternal usual nutrient intakes and dietary pattern scores [Healthy Eating Index-2010 (HEI-2010), Dietary Inflammatory Index (DII), and Relative Mediterranean Diet Score (rMED)]. Offspring hepatic fat was measured in early childhood by MRI. Associations of maternal dietary predictors during pregnancy with offspring log-transformed hepatic fat were assessed using linear regression models adjusted for offspring demographics, maternal/perinatal confounders, and maternal total energy intake.Results: Higher maternal fiber intake and rMED scores during pregnancy were associated with lower offspring hepatic fat in early childhood in fully adjusted models [Back-transformed beta (95% CI): 0.82 (0.72, 0.94) per 5 g/1000 kcal fiber; 0.93 (0.88, 0.99) per 1 SD for rMED]. In contrast, higher maternal total sugar and added sugar intakes, and DII scores were associated with higher offspring hepatic fat [Back -transformed beta (95% CI): 1.18 (1.05, 1.32) per 5% kcal/d added sugar; 1.08 (0.99, 1.18) per 1 SD for DII]. Analyses of dietary pattern subcomponents also revealed that lower maternal intakes of green vegetables and legumes and higher intake of "empty calories" were associated with higher offspring hepatic fat in early childhood.Conclusions: Poorer maternal diet quality during pregnancy was associated with greater offspring susceptibility to hepatic fat in early childhood. Our findings provide insights into potential perinatal targets for the primordial prevention of pediatric NAFLD. C1 [Cohen, Catherine C.; Perng, Wei; Sauder, Katherine A.; Shapiro, Allison L. B.; Starling, Anne P.; Friedman, Chloe; Moore, Brianna F.; Scherzinger, Ann; Shankar, Kartik; Dabelea, Dana] Univ Colorado, Lifecourse Epidemiol Adipos & Diabet Ctr, Colorado Sch Publ Hlth, Anschutz Med Campus, Aurora, CO 80045 USA. [Cohen, Catherine C.; Sauder, Katherine A.; Shapiro, Allison L. B.; Sundaram, Shikha S.; Shankar, Kartik; Dabelea, Dana] Univ Colorado, Dept Pediat, Sch Med, Anschutz Med Campus, Aurora, CO 80045 USA. [Perng, Wei; Starling, Anne P.; Friedman, Chloe; Moore, Brianna F.; Dabelea, Dana] Univ Colorado, Colorado Sch Publ Hlth, Dept Epidemiol, Anschutz Med Campus, Aurora, CO USA. [Perng, Wei] Univ Michigan, Sch Publ Hlth, Dept Nutr Sci, Ann Arbor, MI USA. [Starling, Anne P.] Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Epidemiol, Chapel Hill, NC USA. [Felix, Janine F.; Kuepers, Leanne K.] Univ Med Ctr Rotterdam, Generat Study Grp R, Erasmus MC, Rotterdam, Netherlands. [Felix, Janine F.; Kuepers, Leanne K.] Univ Med Ctr Rotterdam, Dept Paediat, Erasmus MC, Rotterdam, Netherlands. [Hebert, James R.; Shivappa, Nitin] Univ South Carolina, Arnold Sch Publ Hlth, Dept Epidemiol & Biostat, Canc Prevent & Control Program, Columbia, SC USA. [Shivappa, Nitin] Connecting Hlth Innovat LLC, Dept Nutr, Columbia, SC USA. [Scherzinger, Ann] Univ Colorado, Dept Radiol, Sch Med, Anschutz Med Campus, Aurora, CO USA. C3 Colorado School of Public Health; University of Colorado System; University of Colorado Anschutz Medical Campus; University of Colorado System; University of Colorado Anschutz Medical Campus; Colorado School of Public Health; University of Colorado System; University of Colorado Anschutz Medical Campus; University of Michigan System; University of Michigan; University of North Carolina; University of North Carolina Chapel Hill; Erasmus University Rotterdam; Erasmus MC; Erasmus University Rotterdam; Erasmus MC; University of South Carolina System; University of South Carolina Columbia; Connecting Health Innovations LLC; University of Colorado System; University of Colorado Anschutz Medical Campus RP Cohen, CC (通讯作者)，Univ Colorado, Lifecourse Epidemiol Adipos & Diabet Ctr, Colorado Sch Publ Hlth, Anschutz Med Campus, Aurora, CO 80045 USA.; Cohen, CC (通讯作者)，Univ Colorado, Dept Pediat, Sch Med, Anschutz Med Campus, Aurora, CO 80045 USA. EM catherine.cohen@cuanschutz.edu RI Moore, Brianna/AAZ-1342-2020; Shivappa, Nitin/X-2215-2018; Hebert, James/IUO-5628-2023; Cohen, Catherine/AAA-6623-2021 OI Moore, Brianna/0000-0002-1084-3349; Cohen, Catherine/0000-0002-8402-0118; Shankar, Kartik/0000-0002-7964-9026; FU National Institute of Diabetes, Digestive, and Kidney Disease (NIDDK) [R01-DK076648]; National Insistutes of Health (NIH) Office of The Director grant [UH3-OD023248]; National Center for Advancing Translational Sciences (NCATS) [UL1-TR002535]; NIDDK [T32-DK07658, F32-DK131757, P30-DK056350]; NCATS [KL2-TR002534]; NIH [P30DK048520, R01DK121497, R01ES032176]; European Union [874739]; European Joint Programming Initiative "A Healthy Diet for a Healthy Life" (JPI HDHL, NutriPROGRAM project, ZonMw The Netherlands) [529051022]; PREcisE project ZonMw The Netherlands [529051023]; National Institute of Diabetes and Digestive and Kidney Diseases [F32DK131757, P30DK048520, T32DK007658] Funding Source: NIH RePORTER; NIH Office of the Director [UH3OD023248] Funding Source: NIH RePORTER FX The Healthy Start Study was supported by National Institute of Diabetes, Digestive, and Kidney Disease (NIDDK) grant no. R01-DK076648 and National Insistutes of Health (NIH) Office of The Director grant no. UH3-OD023248 to DD. This work was also supported by National Center for Advancing Translational Sciences (NCATS) grant no. UL1-TR002535 to the Colorado Clinical Translational Sciences Institute and NIDDK grant no. P30-DK056350 to the University of North Carolina Nutrition Obesity Research Center. CCC was supported by NIDDK grant no. T32-DK07658 and F32-DK131757. WP was supported by NCATS grant no. KL2-TR002534. KS is supported in part by grants from the NIH (P30DK048520, R01DK121497, and R01ES032176) . The work of JFF and LKK is supported by the European Union's Horizon 2020 research and innovation program (874739, Lon-gITools) and the European Joint Programming Initiative "A Healthy Diet for a Healthy Life" (JPI HDHL, NutriPROGRAM project, ZonMw The Netherlands no. 529051022 and PREcisE project ZonMw The Netherlands no. 529051023) . Contents are the authors' sole responsibility and do not necessarily represent official NIH views. 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PD APR PY 2023 VL 153 IS 4 BP 1122 EP 1132 DI 10.1016/j.tjnut.2023.01.039 EA APR 2023 PG 11 WC Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Nutrition & Dietetics GA F8RL3 UT WOS:000984963600001 PM 36796482 OA Green Submitted DA 2026-02-02 ER PT J AU Ferri, S Stefanini, B Minguzzi, M Leoni, S Capelli, R Secomandi, A Chen, RS Abbati, C Santangeli, E Mattarozzi, K Fabio, P AF Ferri, Silvia Stefanini, Bernardo Minguzzi, Marta Leoni, Simona Capelli, Roberta Secomandi, Alice Chen, Rusi Abbati, Chiara Santangeli, Ernestina Mattarozzi, Katia Fabio, Piscaglia TI Effects of COVID-19 Pandemic on Metabolic Status and Psychological Correlates of a Cohort of Italian NAFLD Outpatients SO NUTRIENTS LA English DT Article DE NAFLD; COVID-19; metabolic syndrome; psychological distress; behavioral approach ID FATTY LIVER-DISEASE; PHYSICAL-ACTIVITY; MEDITERRANEAN DIET; DEPRESSION; ANXIETY AB Simple Summary One out of four patients with NAFLD and metabolic syndrome is also affected by psychological distress. In this study, we evaluated the impact of a stressful contingency such as the COVID-19 lockdown on a cohort of Italian patients affected by NAFLD. Our data confirmed the association between psychological distress and NAFLD. They also showed how psychological suffering was associated with a worse efficacy of the behavioral therapeutic approach in patients with NAFLD. Non-alcoholic fatty liver disease (NAFLD) is a potentially progressive condition characterized by the presence of fat in more than 5% of hepatocytes, representing the hepatic expression of metabolic syndrome (MetS). A reduction of at least 5-7% in initial body weight improves the metabolic profile underlying NAFLD. The aim of our study was to evaluate the effects of the COVID-19 lockdown on a cohort of non-advanced NAFLD Italian outpatients. We identified 43 patients with 3 available time point visits in our center: first visit (T0) when behavioral indications aimed at controlling MetS were provided, a pre-COVID visit (T1) and a post-COVID visit (T2). During the lockdown, an online compilation of validated psychological tests (SRQ-20, EQ5D, SF-12 and STAI) and a specifically formulated questionnaire for NAFLD was presented to our cohort and completed by 14 consenting patients. Patients who had lost more than 5% of the initial weight at T1 (9 subjects, 21%) maintained the results even at T2, with an overall reduction in BMI and liver stiffness; patients who had not lost the desired weight at T1 (34 subjects, 79%) displayed a further increase in BMI and visceral adiposity at T2. Of interest is that patients in the latter group reported signs of psychological suffering. Our data demonstrated that the setting of good counseling was effective in controlling the metabolic disorder underlying NAFLD in our cohort of outpatients. Given the need for patients to play an active role in the behavioral therapy for NAFLD, we advocate that a multidisciplinary approach be adopted, including a psychological support to obtain the best results over time. C1 [Ferri, Silvia; Leoni, Simona; Fabio, Piscaglia] IRCCS Azienda Osped Univ Bologna, Div Internal Med Hepatobiliary & Immunoallerg Dis, I-40138 Bologna, Italy. [Stefanini, Bernardo; Minguzzi, Marta; Capelli, Roberta; Secomandi, Alice; Chen, Rusi; Abbati, Chiara; Santangeli, Ernestina; Mattarozzi, Katia; Fabio, Piscaglia] Univ Bologna, Dept Med & Surg Sci, I-40126 Bologna, Italy. C3 IRCCS Azienda Ospedaliero-Universitaria di Bologna; University of Bologna RP Fabio, P (通讯作者)，IRCCS Azienda Osped Univ Bologna, Div Internal Med Hepatobiliary & Immunoallerg Dis, I-40138 Bologna, Italy.; Fabio, P (通讯作者)，Univ Bologna, Dept Med & Surg Sci, I-40126 Bologna, Italy. EM fabio.piscaglia@unibo.it RI Stefanini, Bernardo/GWQ-5807-2022; Capelli, Roberta/KIG-6973-2024 OI Stefanini, Bernardo/0000-0003-3800-5678; Minguzzi, Marta/0009-0008-7976-3217 CR Beusenberg M., A user's guide to the self reporting questionnaire (SRQ Brooks R., 2003, MEASUREMENT VALUATIO, DOI [10.1007/978-94-017-0233-1, DOI 10.1007/978-94-017-0233-1] Cortez-Pinto H, 1999, JAMA-J AM MED ASSOC, V282, P1659, DOI 10.1001/jama.282.17.1659 Borges VFDE, 2013, J CLIN ULTRASOUND, V41, P18, DOI 10.1002/jcu.21994 Di Renzo L, 2020, NUTRIENTS, V12, DOI 10.3390/nu12072152 European Association for the Study of the Liver (EASL), 2016, J Hepatol, V64, P1388, DOI 10.1016/j.jhep.2015.11.004 Ferri S, 2022, NUTRIENTS, V14, DOI 10.3390/nu14122493 Fuller BE, 2011, GEN HOSP PSYCHIAT, V33, P232, DOI 10.1016/j.genhosppsych.2011.03.006 Gazzetta Ufficiale, About us Haigh L, 2022, CLIN NUTR, V41, P1913, DOI 10.1016/j.clnu.2022.06.037 Hallsworth K, 2015, FRONTLINE GASTROENTE, V6, P44, DOI 10.1136/flgastro-2014-100432 Ivancovsky-Wajcman D, 2019, DIGEST LIVER DIS, V51, P1698, DOI 10.1016/j.dld.2019.06.005 Jontez NB, 2021, NUTRIENTS, V13, DOI 10.3390/nu13041082 Katsagoni CN, 2017, METABOLISM, V68, P119, DOI 10.1016/j.metabol.2016.12.006 Khan Moien Ab, 2022, Br J Nutr, V127, P298, DOI 10.1017/S0007114521000921 Kiani Aysha Karim, 2022, J Prev Med Hyg, V63, pE36, DOI 10.15167/2421-4248/jpmh2022.63.2S3.2745 Kolokotroni O, 2021, BMC PUBLIC HEALTH, V21, DOI 10.1186/s12889-021-10863-0 Marx W, 2017, P NUTR SOC, V76, P427, DOI 10.1017/S0029665117002026 Mulazzani L, 2019, J HEPATOL, V70, P545, DOI 10.1016/j.jhep.2018.10.012 Oh S, 2015, HEPATOLOGY, V61, P1205, DOI 10.1002/hep.27544 researchgate, Medical Request Form (MN MQ03) Romero-Gómez M, 2017, J HEPATOL, V67, P829, DOI 10.1016/j.jhep.2017.05.016 Ryan MC, 2013, J HEPATOL, V59, P138, DOI 10.1016/j.jhep.2013.02.012 Ryu S, 2015, J HEPATOL, V63, P1229, DOI 10.1016/j.jhep.2015.07.010 Sberna AL, 2018, DIABETIC MED, V35, P368, DOI 10.1111/dme.13565 Shanmugam H, 2021, EUR J CLIN INVEST, V51, DOI 10.1111/eci.13597 Smaga I, 2015, PHARMACOL REP, V67, P569, DOI 10.1016/j.pharep.2014.12.015 Soto-Angona O, 2020, BMC MED, V18, DOI 10.1186/s12916-020-01713-8 Stewart KE, 2015, LIVER INT, V35, P936, DOI 10.1111/liv.12483 Vilar-Gomez E, 2015, GASTROENTEROLOGY, V149, P367, DOI 10.1053/j.gastro.2015.04.005 Ware JE, 1996, MED CARE, V34, P220, DOI 10.1097/00005650-199603000-00003 Wong VWS, 2018, J HEPATOL, V69, P1349, DOI 10.1016/j.jhep.2018.08.011 Youssef NA, 2013, LIVER INT, V33, P1062, DOI 10.1111/liv.12165 NR 33 TC 1 Z9 1 U1 0 U2 1 PU MDPI PI BASEL PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND EI 2072-6643 J9 NUTRIENTS JI Nutrients PD MAR PY 2023 VL 15 IS 6 AR 1445 DI 10.3390/nu15061445 PG 14 WC Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Nutrition & Dietetics GA A8UO7 UT WOS:000957816400001 PM 36986175 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Blanco-Rojo, R Alcala-Diaz, JF Wopereis, S Perez-Martinez, P Quintana-Navarro, GM Marin, C Ordovas, JM van Ommen, B Perez-Jimenez, F Delgado-Lista, J Lopez-Miranda, J AF Blanco-Rojo, Ruth Alcala-Diaz, Juan F. Wopereis, Suzan Perez-Martinez, Pablo Quintana-Navarro, Gracia M. Marin, Carmen Ordovas, Jose M. van Ommen, Ben Perez-Jimenez, Francisco Delgado-Lista, Javier Lopez-Miranda, Jose TI The insulin resistance phenotype (muscle or liver) interacts with the type of diet to determine changes in disposition index after 2 years of intervention: the CORDIOPREV-DIAB randomised clinical trial SO DIABETOLOGIA LA English DT Article DE Beta cell function; Dietary intervention; Insulin resistance; Low-fat diet; Mediterranean diet ID LIFE-STYLE INTERVENTION; MEDITERRANEAN DIET; GLUCOSE-TOLERANCE; SKELETAL-MUSCLE; PREVENTION; SENSITIVITY; HEALTH; RISK; METABOLISM; REDUCTION AB Aims/hypothesis The aim of the study was to determine whether basal insulin resistance (IR) phenotype (muscle and/or liver) determines the effect of long-term consumption of a Mediterranean diet or a low-fat diet on tissue-specific IR and beta cell function. Methods The study was performed in 642 patients included in The effect of an olive oil rich Mediterranean diet on type 2 diabetes mellitus risk and incidence study (CORDIOPREV-DIAB). A total of 327 patients were randomised to a Mediterranean diet (35% fat; 22% from monounsaturated fatty acids) and 315 to a low-fat diet (<28% fat). At baseline, the patients were classified into four phenotypes according to the type of IR: (1) no IR; (2) muscle IR; (3) liver IR; (4) muscle + liver IR. The hepatic insulin resistance index (HIRI), muscular insulin sensitivity index (MISI) and disposition index were analysed at baseline and after 2 years of follow-up. Results At baseline, 322 patients presented no IR, 106 presented muscle IR, 109 presented liver IR, and 105 presented muscle + liver IR. With both dietary interventions, HIRI decreased in all patients (p < 0.001) and MISI increased in muscle IR and muscle + liver IR patients (p < 0.01). Long-term intake of the Mediterranean diet increased the disposition index and insulinogenic index in the muscle IR patients (p = 0.042 and p = 0.044, respectively) and the disposition index in the muscle + liver IR patients (p = 0.048), whereas the low-fat diet increased the disposition index in the liver IR patients (p = 0.017). Conclusions/interpretation Although both diets improve insulin sensitivity, there are differences based on basal IR phenotypes. Moreover, according to insulinogenic and disposition index data, a low-fat diet might be more beneficial to patients with liver IR, whereas patients with muscle IR and muscle + liver IR might benefit more from a Mediterranean diet. C1 [Blanco-Rojo, Ruth; Alcala-Diaz, Juan F.; Perez-Martinez, Pablo; Quintana-Navarro, Gracia M.; Marin, Carmen; Perez-Jimenez, Francisco; Delgado-Lista, Javier; Lopez-Miranda, Jose] Reina Sofia Univ Hosp, Lipids & Atherosclerosis Res Unit, Cordoba 14004, Spain. [Blanco-Rojo, Ruth; Alcala-Diaz, Juan F.; Perez-Martinez, Pablo; Quintana-Navarro, Gracia M.; Marin, Carmen; Perez-Jimenez, Francisco; Delgado-Lista, Javier; Lopez-Miranda, Jose] Maimonides Inst Biomed Res Cordoba IMIBIC, Nutrigen & Metab Syndrome, Cordoba, Spain. [Blanco-Rojo, Ruth; Alcala-Diaz, Juan F.; Perez-Martinez, Pablo; Quintana-Navarro, Gracia M.; Marin, Carmen; Perez-Jimenez, Francisco; Delgado-Lista, Javier; Lopez-Miranda, Jose] Univ Cordoba, Dept Med, Cordoba, Spain. [Blanco-Rojo, Ruth; Alcala-Diaz, Juan F.; Perez-Martinez, Pablo; Quintana-Navarro, Gracia M.; Marin, Carmen; Perez-Jimenez, Francisco; Delgado-Lista, Javier; Lopez-Miranda, Jose] CIBER Fisiopatol Obesidad & Nutr CIBEROBN, Barcelona, Spain. [Wopereis, Suzan; van Ommen, Ben] TNO, NL-3700 AJ Zeist, Netherlands. [Ordovas, Jose M.] Tufts Univ, Jean Mayer US Dept Agr, Human Nutr Res Ctr Aging, Nutr & Genom Lab, Boston, MA 02111 USA. [Ordovas, Jose M.] IMDEA Food Inst, Madrid, Spain. C3 Hospital Universitario Reina Sofia - Cordoba; Universidad de Cordoba; CIBER - Centro de Investigacion Biomedica en Red; CIBEROBN; Netherlands Organization Applied Science Research; Tufts University; United States Department of Agriculture (USDA); IMDEA Food Institute RP Lopez-Miranda, J (通讯作者)，Reina Sofia Univ Hosp, Lipids & Atherosclerosis Res Unit, Avda Menendez Pidal S-N, Cordoba 14004, Spain. EM jlopezmir@uco.es RI Jimenez, Francisco/AAJ-9559-2021; Lopez-Miranda, Jose/Y-8306-2019; Pérez Martínez, Pablo/AEL-6176-2022; Alcala-Diaz, Juan Francisco/Q-4455-2019; Delgado-Lista, Javier/KAM-7412-2024 OI Lopez-Miranda, Jose/0000-0002-8844-0718; Pérez Martínez, Pablo/0000-0001-7716-8117; Alcala-Diaz, Juan Francisco/0000-0002-4572-3611; QUINTANA-NAVARRO, GRACIA MARIA/0000-0003-4413-4062; FU Ministerio de Economia y Competitividad [AGL2012/39615]; Ministerio de Ciencia e Innovacion [PIE14/00005, PI13/00023]; European Commission (NUTRITECH European Integrated Project) [289511]; ISCIII; Instituto de Salud Carlos III research contract (Programa Rio-Hortega) FX The study was supported by the Ministerio de Economia y Competitividad (AGL2012/39615) and by the Ministerio de Ciencia e Innovacion (PIE14/00005 and PI13/00023) The present study was supported by the Ministerio de Economia y Competitividad (AGL2012/39615 to JL-M) and by the Ministerio de Ciencia e Innovacion (PIE14/00005 to JL-M and PI13/00023 to JD-L). It was also partly supported by a research grant from the European Commission (NUTRITECH European Integrated Project-289511). RB-R is supported by an ISCIII postdoctoral research contract (Sara Borrell) and JFA-D is supported by an Instituto de Salud Carlos III research contract (Programa Rio-Hortega). 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Olive oil rich diet decrease accumulation of triglyceride in the liver, improved postprandial triglyceride levels, improve glucose and GLP-1 response in insulin resistant subjects, and up regulate GLUT-2 expression in the liver. The exact molecular mechanism is unknown but, decreasing NFkB activation, decreasing LDL oxidation and improving insulin resistance by less production of inflammatory cytokines (TNF-a, IL-6) and improvement of kinases JNK-mediated phosphorylation of IRS-1 are the principle mechanisms. The beneficial effect of the Mediterranean diet derived from monounsaturated fatty acids (MUFA), mainly from olive oil. In this review we document lipotoxicity in obesity and the benefit of olive oil. C1 [Elias, Saad; Wisam, Sbeit; Luai, Arraf; Massad, Barhoum; Nimer, Assy] Bar Ilan Univ, Fac Med, A Galilee Med Ctr, Dept Internal Med, Safed, Israel. C3 Bar Ilan University RP Nimer, A (通讯作者)，Bar Ilan Univ, Fac Med, A Galilee Med Ctr, Dept Internal Med, Safed, Israel. 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10.1074/jbc.M200958200 NR 83 TC 8 Z9 10 U1 0 U2 5 PU SPRINGER INTERNATIONAL PUBLISHING AG PI CHAM PA GEWERBESTRASSE 11, CHAM, CH-6330, SWITZERLAND SN 0065-2598 EI 2214-8019 BN 978-3-319-48382-5; 978-3-319-48380-1 J9 ADV EXP MED BIOL JI Adv.Exp.Med.Biol. PY 2017 VL 960 BP 607 EP 617 DI 10.1007/978-3-319-48382-5_26 D2 10.1007/978-3-319-48382-5 PG 11 WC Endocrinology & Metabolism; Medicine, Research & Experimental; Physiology WE Book Citation Index– Science (BKCI-S); Science Citation Index Expanded (SCI-EXPANDED) SC Endocrinology & Metabolism; Research & Experimental Medicine; Physiology GA BS6WL UT WOS:000753914500027 PM 28585218 DA 2026-02-02 ER PT J AU Aron-Wisnewsky, J Warmbrunn, M Nieuwdorp, M Clément, K AF Aron-Wisnewsky, Judith Warmbrunn, Moritz, V Nieuwdorp, Max Clement, Karine TI Nonalcoholic Fatty Liver Disease: Modulating Gut Microbiota to Improve Severity? SO GASTROENTEROLOGY LA English DT Article ID INTERNATIONAL SCIENTIFIC ASSOCIATION; TIGHT JUNCTION PERMEABILITY; INTESTINAL MICROBIOTA; MEDITERRANEAN DIET; FECAL MICROBIOTA; OBESE-PATIENTS; DOUBLE-BLIND; WHOLE-GRAIN; WEIGHT-LOSS; AKKERMANSIA-MUCINIPHILA C1 [Aron-Wisnewsky, Judith; Clement, Karine] Sorbonne Univ, Nutri Res Unit, UMRS U1269, INSERM, 46-83 Blvd Hop, F-75003 Paris, France. [Aron-Wisnewsky, Judith; Clement, Karine] Hop La Pitie Salpetriere, AP HP, Ctr Rech Nutr Humaine Ile de France, Nutr Dept, Paris, France. [Aron-Wisnewsky, Judith; Warmbrunn, Moritz, V; Nieuwdorp, Max] Univ Amsterdam, Dept Vasc Med, Med Ctr, Amsterdam, Netherlands. [Nieuwdorp, Max] Free Univ Amsterdam, Univ Amsterdam, Dept Internal Med, Med Ctr, Amsterdam, Netherlands. C3 Institut National de la Sante et de la Recherche Medicale (Inserm); Sorbonne Universite; Sorbonne Universite; Assistance Publique Hopitaux Paris (APHP); Hopital Universitaire Pitie-Salpetriere - APHP; University of Amsterdam; Vrije Universiteit Amsterdam; University of Amsterdam RP Aron-Wisnewsky, J; Clément, K (通讯作者)，Sorbonne Univ, Nutri Res Unit, UMRS U1269, INSERM, 46-83 Blvd Hop, F-75003 Paris, France. EM judith.aron-wisnewsky@psl.aphp.fr; karine.clement@psl.aphp.fr RI ; ARON-WISNEWSKY, judith/AAH-7608-2020; Clément, karine/R-1120-2017 OI Warmbrunn, Moritz Valerian/0000-0003-3548-6728; FU EU LITMUS; Le Ducq consortium [17CVD01]; JPIHDHL (Joint Programming Initiative-A Healthy Diet for a Healthy Life) MICRODIET consortium grant; Bettencourt Shueller foundation; ZonMw-Vidi grant 2013 [016.146.327]; CVON [CVON 2O18.27] FX Supported by EU LITMUS (Liver Investigation: Testing Marker Utility in Steatohepatitis) grant (to M.N. and K.C.). The authors were additionally supported by Le Ducq consortium grant 17CVD01 to M.N. and K.C., JPIHDHL (Joint Programming Initiative-A Healthy Diet for a Healthy Life) MICRODIET consortium grant to M.N. and K.C. J.A.W. received a grant from Bettencourt Shueller foundation. Finally, M. Nieuwdorp is supported by a personal ZonMw-Vidi grant 2013 (016.146.327), M.W. is supported by a CVON grant (CVON 2O18.27). CR Agheli N, 1998, J NUTR, V128, P1283, DOI 10.1093/jn/128.8.1283 Alisi A, 2014, ALIMENT PHARM THER, V39, P1276, DOI 10.1111/apt.12758 Aller R, 2011, EUR REV MED PHARMACO, V15, P1090 Allin KH, 2018, DIABETOLOGIA, V61, P810, DOI 10.1007/s00125-018-4550-1 Anh SB, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-42059-3 Anjani K, 2015, J HEPATOL, V62, P905, DOI 10.1016/j.jhep.2014.11.002 [Anonymous], 2019, CLIN GASTROENTEROL H [Anonymous], SCI REP [Anonymous], 2019, FRONT MICROBIOL, DOI DOI 10.3389/fmicb.2019.01047 [Anonymous], perspective. Microbiol. Spectr. 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19103-2899 USA SN 0016-5085 EI 1528-0012 J9 GASTROENTEROLOGY JI Gastroenterology PD MAY PY 2020 VL 158 IS 7 SI SI BP 1881 EP 1898 PG 18 WC Gastroenterology & Hepatology WE Science Citation Index Expanded (SCI-EXPANDED) SC Gastroenterology & Hepatology GA LP0OT UT WOS:000534022200004 PM 32044317 HC Y HP N DA 2026-02-02 ER PT J AU Sá, C Oliveira, AR Machado, C Azevedo, M Pereira-Wilson, C AF Sa, Carla Oliveira, Ana Rita Machado, Catia Azevedo, Marisa Pereira-Wilson, Cristina TI Effects on Liver Lipid Metabolism of the Naturally Occurring Dietary Flavone Luteolin-7-glucoside SO EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE LA English DT Article ID NONALCOHOLIC FATTY LIVER; INSULIN-RESISTANCE; URSOLIC ACID; HEPG2 CELLS; DISEASE; LUTEOLIN; ACTIVATION; MECHANISM; INCREASE; HABITS AB Disruptions in whole-body lipid metabolism can lead to the onset of several pathologies such as nonalcoholic fatty liver disease (NAFLD) and cardiovascular diseases (CVDs). The present study aimed at elucidating the molecular mechanisms behind the lipid-lowering effects of the flavone luteolin-7-glucoside (L7G) which we previously showed to improve plasma lipid profile in rats. L7G is abundant in plant foods of Mediterranean diet such as aromatic plants used as herbs. Results show that dietary supplementation with L7G for one week induced the expression of peroxisome proliferator-activated receptor-alpha (PPAR-alpha) and of its target gene carnitine palmitoyl transferase 1 (CPT-1) in rat liver. L7G showed a tendency to decrease the hepatic expression of sterol regulatory element-binding protein-1 (SREBP-1), without affecting fatty acid synthase (FAS) protein levels. Although SREBP-2 and LDLr mRNA levels did not change, the expression of HMG CoA reductase (HMGCR) was significantly repressed by L7G. L7G also inhibited this enzyme's in vitro activity in a dose dependent manner, but only at high and not physiologically relevant concentrations. These results add new evidence that the flavone luteolin-7-glucoside may help in preventing metabolic diseases and clarify the mechanisms underlying the beneficial health effects of diets rich in fruits and vegetables. C1 [Sa, Carla; Oliveira, Ana Rita; Machado, Catia; Azevedo, Marisa; Pereira-Wilson, Cristina] Univ Minho, Sch Sci, Dept Biol, P-4710057 Braga, Portugal. [Oliveira, Ana Rita; Machado, Catia; Pereira-Wilson, Cristina] Univ Minho, Dept Biol, Sch Sci, Ctr Res & Technol Agroenvironm & Biol Sci CITAB, P-4710057 Braga, Portugal. C3 Universidade do Minho; Universidade do Minho RP Pereira-Wilson, C (通讯作者)，Univ Minho, Sch Sci, Dept Biol, P-4710057 Braga, Portugal. EM cpereira.bio.uminho@gmail.com RI Sá, Carla/I-6640-2013; Pereira-Wilson, Cristina/F-1967-2013; Machado, Cátia/ITT-1617-2023; Oliveira, Ana Rita/AAI-4046-2020 OI Sá, Carla/0000-0002-4833-6211; Pereira-Wilson, Cristina/0000-0002-3714-8258; Machado, Cátia/0000-0003-4490-141X; Oliveira, Ana Rita/0000-0001-7828-4152 FU Portuguese Foundation for Science and Technology (FCT) [PEst-OE/AGR/UI4033/2014]; Portuguese Foundation for Science and Technology [SFRH/BD/42566/2007]; Fundação para a Ciência e a Tecnologia [SFRH/BD/42566/2007, PEst-OE/AGR/UI4033/2014] Funding Source: FCT FX This work is supported by national funds by Portuguese Foundation for Science and Technology (FCT), under Project PEst-OE/AGR/UI4033/2014. CS was supported by the Portuguese Foundation for Science and Technology, through Grant SFRH/BD/42566/2007. 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Med. PY 2015 VL 2015 AR 647832 DI 10.1155/2015/647832 PG 9 WC Integrative & Complementary Medicine WE Science Citation Index Expanded (SCI-EXPANDED) SC Integrative & Complementary Medicine GA CL3CO UT WOS:000356827200001 PM 26113868 OA Green Submitted, hybrid DA 2026-02-02 ER PT J AU Cano-Lallave, L Ruiz-Tovar, J Martin-de-Bernardo, L Martinez-Oribe, M Rodriguez-Obispo, C Carrascosa-Corrochano, S Martín-Nieto, A Baeza, I Gonzalez-Ramos, M Benito, M Olazabal, I AF Cano-Lallave, Laura Ruiz-Tovar, Jaime Martin-de-Bernardo, Lucia Martinez-Oribe, Malena Rodriguez-Obispo, Cristina Carrascosa-Corrochano, Sara Martin-Nieto, Ana Baeza, Isabel Gonzalez-Ramos, Marta Benito, Marta Olazabal, Isabel TI Influence of Adherence to the Mediterranean Diet and Level of Physical Activity with Liver Steatosis in People Aged > 50 Years and with a BMI > 25 kg/m2: Association with Biochemical Markers SO NUTRIENTS LA English DT Article DE hepatic steatosis; non-alcoholic fatty liver disease; NAFLD; cardiovascular risk factors; biochemical markers; Mediterranean diet; adherence; physical activity; obesity ID HEPATIC STEATOSIS; DISEASE; INDIVIDUALS AB Background: The main objective of this study is to determine the accuracy of different biochemical markers of hepatic steatosis and to correlate liver steatosis with adherence to the Mediterranean diet and level of physical activity. Methods: A cross-sectional study was carried out, including subjects over 50 years of age, with a BMI > 25 kg/m(2), but excluding any patient with documented hepatic pathology other than hepatic steatosis. Participants were divided into two groups: patients with hepatic steatosis diagnosed by ultrasound (SG) and a control group of individuals without hepatic steatosis (CG). The level of physical activity was recorded by the IPAQ-SF questionnaire and the adherence to the Mediterranean diet was recorded using the PREDIMED questionnaire. Biochemical markers analyzed included the Hepatic steatosis index (HSI), AST-to-Platelet ratio (APRI) and Fibrosis-4 (FIB-4). Results: A total of 116 patients were included, 71 belonging to the SG and 45 to the CG. A total of 58.6% of the patients showed low adherence to the Mediterranean diet, 35.4% moderate adherence and 6% high adherence. The median estimated physical activity was 495 METS, with most participants reporting light activity. In the SG, significantly higher HSI values were observed (p < 0.001). A cut-off point of a HSI of 40 was established, with a sensitivity of 73.2% and a specificity of 65.8%. Significantly higher FIB-4 values (p = 0.039) were also observed in the SG. A cut-off point of FIB-4 was set at 0.27, with a sensitivity of 69% and a specificity of 57.9%. Patients in the SG showed lower scores in the PREDIMED. Patients in the SG tended to show lower METS scores. However, the higher number of patients with intense activity in the CG group stands out (p = 0.008). Conclusions: The HSI and FIB-4 showed a significant correlation with liver steatosis. Hepatic steatosis is associated with low adherence to the Mediterranean diet and patients with hepatic steatosis tended to have lower METS scores. C1 [Cano-Lallave, Laura] Alfonso X Univ, Sch Med, Dept Hlth Sci, Madrid 28691, Spain. [Ruiz-Tovar, Jaime; Martin-Nieto, Ana; Baeza, Isabel; Gonzalez-Ramos, Marta; Benito, Marta] San Juan Dios Fdn, Madrid 28015, Spain. [Ruiz-Tovar, Jaime; Martin-Nieto, Ana; Baeza, Isabel; Gonzalez-Ramos, Marta; Benito, Marta] Comillas Pontifical Univ, San Juan Dios Sch Nursing & Phys Therapy, Hlth Sci Dept, Madrid 28015, Spain. [Martin-de-Bernardo, Lucia; Martinez-Oribe, Malena; Rodriguez-Obispo, Cristina; Carrascosa-Corrochano, Sara; Olazabal, Isabel] Univ Alfonso X Sabio, Dept Human Nutr, Av Univ 1, Madrid 28691, Spain. C3 Comillas Pontifical University; Universidad Alfonso X el Sabio (UAX) RP Ruiz-Tovar, J (通讯作者)，San Juan Dios Fdn, Madrid 28015, Spain.; Ruiz-Tovar, J (通讯作者)，Comillas Pontifical Univ, San Juan Dios Sch Nursing & Phys Therapy, Hlth Sci Dept, Madrid 28015, Spain. EM lcanolal@uax.es; jruiztovar@euef.comillas.edu; lmartind@myuax.com; morivmar@myuax.com; cobisrod@myuax.com; scarrcor@myuax.com; amartinn@comillas.edu; ibaeza@comillas.edu; mogonzalezr@comillas.edu; mbenitom@comillas.edu; iolazola@uax.es RI ; Olazabal, Isabel/NJR-3698-2025; Benito Miguel, Marta/O-8776-2014 OI Gonzalez-Ramos, Marta/0000-0003-2717-4417; Olazabal, Isabel/0000-0002-6579-0328; RUIZ-TOVAR, JAIME/0000-0002-8505-2605; Benito Miguel, Marta/0000-0002-2023-1063; Rodríguez, Cristina/0009-0003-6562-3743 CR Abdelmalek M.F., 2018, Harrison Principios De Medicina Interna, VVolume 2, P2401 Berzigotti A, 2021, J HEPATOL, V75, P659, DOI 10.1016/j.jhep.2021.05.025 Carnevale R, 2018, BRIT J CLIN PHARMACO, V84, P1566, DOI 10.1111/bcp.13589 Costarelli V, 2013, QUAL LIFE RES, V22, P951, DOI 10.1007/s11136-012-0219-2 Dernini S, 2017, PUBLIC HEALTH NUTR, V20, P1322, DOI 10.1017/S1368980016003177 Enciso LC, 2024, NUTRIENTS, V16, DOI 10.3390/nu16091308 Estruch R, 2018, NEW ENGL J MED, V378, DOI [10.1056/NEJMoa1200303, 10.1056/NEJMoa1800389, 10.1056/nejmoa1800389] Flier J.S., 2018, Harrison Principios De Medicina Interna, V20th, P2837 Garca-Gmez-Heras S., 2019, Liver Steatosis and Bariatric Surgery, P314 García-Gavilán JF, 2024, AM J CLIN NUTR, V119, P1143, DOI 10.1016/j.ajcnut.2024.02.021 García-Gavilán J, 2022, MOL NUTR FOOD RES, V66, DOI 10.1002/mnfr.202200145 Godos J, 2017, INT J FOOD SCI NUTR, V68, P18, DOI 10.1080/09637486.2016.1214239 Graffigna Mabel, 2017, Rev. argent. endocrinol. metab., V54, P37, DOI 10.1016/j.raem.2016.12.001 Hallsworth M, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0137306 Liu YY, 2024, SCI REP-UK, V14, DOI 10.1038/s41598-024-62677-w Lonardo A, 2017, WORLD J GASTROENTERO, V23, P6571, DOI 10.3748/wjg.v23.i36.6571 Lydakis C, 2012, EUR J PEDIATR, V171, P1373, DOI 10.1007/s00431-012-1735-3 Mamplekou E, 2010, J NUTR HEALTH AGING, V14, P449 Markovic AK, 2019, MOLECULES, V24, DOI 10.3390/molecules24102001 Mente A, 2009, ARCH INTERN MED, V169, P659, DOI 10.1001/archinternmed.2009.38 Misciagna G, 2017, J NUTR HEALTH AGING, V21, P404, DOI 10.1007/s12603-016-0809-8 oarc, UCLA Statistical Methods and Data Analytics Arab JP, 2018, ANN HEPATOL, V17, P899, DOI 10.5604/01.3001.0012.7188 Ruiz-Tovar J, 2019, SURG OBES RELAT DIS, V15, P1447, DOI 10.1016/j.soard.2019.05.004 Ryan MC, 2013, J HEPATOL, V59, P138, DOI 10.1016/j.jhep.2013.02.012 Saavedra Y, 2022, GASTROENT HEPAT-BARC, V45, P350, DOI 10.1016/j.gastrohep.2021.06.006 Sánchez-Villegas A, 2002, EUR J NUTR, V41, P249, DOI 10.1007/s00394-002-0382-2 Sofi F, 2008, BMJ-BRIT MED J, V337, DOI 10.1136/bmj.a1344 Teixeira Beatriz, 2024, Science of The Total Environment, V945, P174051, DOI [10.1016/j.scitotenv.2024.174051, 10.1016/j.scitotenv.2024.174051] Tosti V, 2018, J GERONTOL A-BIOL, V73, P318, DOI 10.1093/gerona/glx227 Velasco N, 2014, CURR OPIN CLIN NUTR, V17, P453, DOI 10.1097/MCO.0000000000000071 Wilhelm RA, 2024, PSYCHOL SPORT EXERC, V74, DOI 10.1016/j.psychsport.2024.102679 Willett Walter C., 1995, American Journal of Clinical Nutrition, V61, p1402S, DOI 10.1093/ajcn/61.6.1402S Wu L, 2017, BIOCHEMISTRY-US, V56, P5035, DOI 10.1021/acs.biochem.7b00199 Zapata I, 2022, INT J ENV RES PUB HE, V19, DOI 10.3390/ijerph192013213 Zubiaga Toro Lorea, 2014, Nutr. Hosp., V30, P281, DOI 10.3305/nh.2014.30.2.7581 NR 36 TC 3 Z9 3 U1 0 U2 1 PU MDPI PI BASEL PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND EI 2072-6643 J9 NUTRIENTS JI Nutrients PD JUL PY 2024 VL 16 IS 13 AR 1996 DI 10.3390/nu16131996 PG 13 WC Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Nutrition & Dietetics GA YR3O7 UT WOS:001270172800001 PM 38999744 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Musolino, V Macrì, R Cardamone, A Serra, M Coppoletta, AR Tucci, L Maiuolo, J Lupia, C Scarano, F Carresi, C Nucera, S Bava, I Marrelli, M Palma, E Gliozzi, M Mollace, V AF Musolino, Vincenzo Macri, Roberta Cardamone, Antonio Serra, Maria Coppoletta, Anna Rita Tucci, Luigi Maiuolo, Jessica Lupia, Carmine Scarano, Federica Carresi, Cristina Nucera, Saverio Bava, Irene Marrelli, Mariangela Palma, Ernesto Gliozzi, Micaela Mollace, Vincenzo TI Nocellara Del Belice (Olea europaea L. Cultivar): Leaf Extract Concentrated in Phenolic Compounds and Its Anti-Inflammatory and Radical Scavenging Activity SO PLANTS-BASEL LA English DT Article DE oleaceae; Olea europaea L; waste by-product; leaf extract; polyphenolic compounds; oleuropein; luteolin-7-O-glucoside; electron paramagnetic resonance (EPR); non-alcoholic fatty liver disease; metabolic associated fatty liver disease (NAFLD; MAFLD); antioxidant anti-inflammatory activity ID ULTRASOUND-ASSISTED EXTRACTION; HIGH-FAT DIET; OLIVE LEAVES; ANTIOXIDANT ACTIVITY; HEPATIC STEATOSIS; RAT HEPATOCYTES; BY-PRODUCTS; OLEUROPEIN; OPTIMIZATION; PURIFICATION AB Olea europaea L. is a plant belonging to the Oleaceae family, widely grown around the Mediterranean Basin and its leaves are a source of phenolic compounds with antioxidant and anti-inflammatory capacity. Among these, oleuropein and luteolin-7-O-glucoside represent two major polyphenolic compounds in olive-leaf extract. Herein, a polystyrene resin was used to recover the polyphenolic fraction from the acetone-water leaf extract from Nocellara del Belice cultivar, which showed the higher level of analysed bioactive compounds, compared to Carolea cultivar. The antioxidant activity of the extract concentrated in phenolic compounds (OLECp) was evaluated through a classical assay and electron paramagnetic resonance (EPR) for DPPH and hydroxyl radicals scavenging. Thus, the anti-inflammatory activity and the potential beneficial effects in reducing lipid accumulation in an in vitro model of NAFLD using McA-RH7777 cells exposed to oleic acid (OA) were evaluated. Nile Red and Oil Red O have been used to stain the lipid accumulation, while the inflammatory status was assessed by Cytokines Bioplex Assay. OLECp (TPC: 92.93 +/- 9.35 mg GAE/g, TFC: 728.12 +/- 16.04 mg RE/g; 1 g of extract contains 315.250 mg of oleuropein and 17.44 mg of luteolin-7-O-glucoside) exerted a good radical scavenging capability (IC50: 2.30 +/- 0.18 mg/mL) with a neutralizing power against DPPH and hydroxyl radicals, as confirmed by the decreased signal area of the EPR spectra. Moreover, OLECp at concentration of 25, 50 and 100 mu g/mL counteracted the intracellular inflammatory status, as result of decreased intracellular lipid content. Our results highlighted the multiple properties and applications of an O. europaea extract concentrated in polyphenols, and the possibility to formulate novel nutraceuticals with antioxidant properties, destined to ameliorate human health. C1 [Musolino, Vincenzo; Macri, Roberta; Maiuolo, Jessica] Magna Graecia Univ Catanzaro, Inst Res Food Safety & Hlth IRC FSH, Dept Hlth Sci, Lab Pharmaceut Biol, I-88100 Catanzaro, Italy. [Musolino, Vincenzo; Macri, Roberta; Cardamone, Antonio; Serra, Maria; Coppoletta, Anna Rita; Tucci, Luigi; Maiuolo, Jessica; Lupia, Carmine; Scarano, Federica; Carresi, Cristina; Nucera, Saverio; Bava, Irene; Palma, Ernesto; Gliozzi, Micaela; Mollace, Vincenzo] Magna Graecia Univ Catanzaro, Inst Res Food Safety & Hlth IRC FSH, Dept Hlth Sci, I-88100 Catanzaro, Italy. [Marrelli, Mariangela] Univ Calabria, Dept Pharm Hlth & Nutr Sci, I-87036 Arcavacata Di Rende, Italy. C3 Magna Graecia University of Catanzaro; Magna Graecia University of Catanzaro; University of Calabria RP Musolino, V (通讯作者)，Magna Graecia Univ Catanzaro, Inst Res Food Safety & Hlth IRC FSH, Dept Hlth Sci, Lab Pharmaceut Biol, I-88100 Catanzaro, Italy.; Musolino, V (通讯作者)，Magna Graecia Univ Catanzaro, Inst Res Food Safety & Hlth IRC FSH, Dept Hlth Sci, I-88100 Catanzaro, Italy. EM v.musolino@unicz.it RI Musolino, Vincenzo/AAC-6429-2022; Gliozzi, Micaela/D-4405-2015; Maiuolo, Jessica/AAU-2482-2020; nucera, saverio/AAC-6570-2022; Coppoletta, Anna Rita/LSK-7367-2024; Cardamone, Antonio/HGA-5612-2022; serra, maria/LSJ-0107-2024; MACRI', Roberta/IQR-9234-2023; carresi, cristina/AAC-6354-2022; PALMA, Ernesto/KRP-9299-2024; SCARANO, FEDERICA/HNC-2414-2023 OI , Luigi/0000-0002-2470-8674; Coppoletta, Anna Rita/0009-0000-5576-1139; Cardamone, Antonio/0000-0002-9091-1806; serra, maria/0009-0005-7736-2207; MACRI', Roberta/0000-0002-2345-6751; carresi, cristina/0000-0002-3509-5930; PALMA, Ernesto/0000-0003-4199-207X; Marrelli, Mariangela/0000-0002-3741-4261; SCARANO, FEDERICA/0000-0002-9838-9469 CR Abaza L, 2015, ANTIOXIDANTS, V4, P682, DOI 10.3390/antiox4040682 Acar-Tek N, 2020, ANN NUTR METAB, V76, P10, DOI 10.1159/000505508 Ahamad J, 2019, PHYTOTHER RES, V33, P3112, DOI 10.1002/ptr.6511 Akar Z, 2017, J ENZYM INHIB MED CH, V32, P640, DOI 10.1080/14756366.2017.1284068 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10.1186/s13020-018-0177-x Zhang YW, 2021, AM J PHYSIOL-GASTR L, V320, pG531, DOI 10.1152/ajpgi.00342.2020 NR 113 TC 19 Z9 20 U1 6 U2 24 PU MDPI PI BASEL PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND SN 2223-7747 J9 PLANTS-BASEL JI Plants-Basel PD JAN PY 2023 VL 12 IS 1 AR 27 DI 10.3390/plants12010027 PG 23 WC Plant Sciences WE Science Citation Index Expanded (SCI-EXPANDED) SC Plant Sciences GA 7P3TR UT WOS:000908632600001 PM 36616158 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Zelber-Sagi, S Ivancovsky-Wajcman, D Isakov, NF Webb, M Orenstein, D Shibolet, O Kariv, R AF Zelber-Sagi, Shira Ivancovsky-Wajcman, Dana Isakov, Naomi Fliss Webb, Muriel Orenstein, Dana Shibolet, Oren Kariv, Revital TI High red and processed meat consumption is associated with non-alcoholic fatty liver disease and insulin resistance SO JOURNAL OF HEPATOLOGY LA English DT Article DE Fatty liver; Red meat; Processed meat; Diet; Insulin resistance; Heterocyclic amines ID GLYCATION END-PRODUCTS; HETEROCYCLIC AMINES; MEDITERRANEAN DIET; DIABETES-MELLITUS; RISK-FACTORS; FOLLOW-UP; HEALTH; INFLAMMATION; POPULATION; STEATOSIS AB Background & Aims: High red and processed meat consumption is related to type 2 diabetes. In addition, cooking meat at high temperatures for a long duration forms heterocyclic amines (HCAs), which are related to oxidative stress. However, the association between meat consumption and non-alcoholic fatty liver disease (NAFLD) is yet to be thoroughly tested. Therefore, we aimed to test the association of meat type and cooking method with NAFLD and insulin resistance (IR). Methods: This was a cross-sectional study in individuals who were 40-70 years old and underwent screening colonoscopy between 2013 and 2015 in a single center in Israel. NAFLD and IR were evaluated by ultrasonography and homeostasis model assessment. Meat type and cooking method were measured by a food frequency questionnaire (FFQ) and a detailed meat questionnaire. Unhealthy cooking methods were considered as frying and grilling to a level of well done and very well done. Dietary HCA intake was calculated. Results: A total of 789 individuals had a valid FFQ and 357 had a valid meat questionnaire. High consumption of total meat (portions/day above the median) (odds ratio [OR] 1.49; 95% CI 1.05-2.13; p = 0.028; OR 1.63; 1.12-2.37; p = 0.011), red and/ or processed meat (OR 1.47; 95% CI 1.04-2.09; p = 0.031; OR 1.55; 1.07-2.23; p = 0.020) was independently associated with higher odds of NAFLD and IR, respectively, when adjusted for: body mass index, physical activity, smoking, alcohol, energy, saturated fat and cholesterol intake. High intake of meat cooked using unhealthy methods (OR 1.92; 95% CI 1.12-3.30; p = 0.018) and HCAs (OR 2.22; 95% CI 1.28-3.86; p = 0.005) were independently associated with higher odds of IR. Conclusion: High consumption of red and/or processed meat is associated with both NAFLD and IR. High HCA intake is associated with IR. If confirmed in prospective studies, limiting the consumption of unhealthy meat types and improving preparation methods may be considered as part of NAFLD lifestyle treatment. Lay summary: High red and processed meat consumption is related to several diseases. In addition, cooking meat at high temperatures for a long duration forms heterocyclic amines, which have harmful health effects. Non-alcoholic fatty liver disease is a significant public health burden and its formation is strongly related to insulin resistance. In this study, both were found to be more frequent in people who consume relatively high quantities of red and processed meat. In addition, a high intake of heterocyclic amines was associated with insulin resistance. (C) 2018 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved. C1 [Zelber-Sagi, Shira; Isakov, Naomi Fliss; Webb, Muriel; Shibolet, Oren; Kariv, Revital] Tel Aviv Med Ctr & Sch Med, Dept Gastroenterol, IL-6423906 Tel Aviv, Israel. [Zelber-Sagi, Shira; Ivancovsky-Wajcman, Dana; Orenstein, Dana] Univ Haifa, Sch Publ Hlth, IL-3498838 Haifa, Israel. [Webb, Muriel; Shibolet, Oren; Kariv, Revital] Tel Aviv Univ, Sackler Fac Med, IL-6997801 Tel Aviv, Israel. C3 Tel Aviv University; Sackler Faculty of Medicine; University of Haifa; Tel Aviv University; Sackler Faculty of Medicine RP Zelber-Sagi, S (通讯作者)，Tel Aviv Med Ctr & Sch Med, Dept Gastroenterol, Liver Unit, IL-6423906 Tel Aviv, Israel. EM zelbersagi@bezeqint.net RI Kariv, Revital/HLW-2074-2023; Ivancovsky-Wajcman, Dana/HDO-6146-2022 FU Research Grants and Fellowships Fund on Food and Nutrition; Israeli Ministry of Health FX Research Grants and Fellowships Fund on Food and Nutrition and their Implications on Public Health, The Israeli Ministry of Health. 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Hepatol. PD JUN PY 2018 VL 68 IS 6 BP 1239 EP 1246 DI 10.1016/j.jhep.2018.01.015 PG 8 WC Gastroenterology & Hepatology WE Science Citation Index Expanded (SCI-EXPANDED) SC Gastroenterology & Hepatology GA GG2AD UT WOS:000432491000016 PM 29571924 HC Y HP N DA 2026-02-02 ER PT J AU Vergani, L Vecchione, G Baldini, F Grasselli, E Voci, A Portincasa, P Ferrari, PF Aliakbarian, B Casazza, AA Perego, P AF Vergani, Laura Vecchione, Giulia Baldini, Francesca Grasselli, Elena Voci, Adriana Portincasa, Piero Ferrari, Pier Francesco Aliakbarian, Bahar Casazza, Alessandro A. Perego, Patrizia TI Polyphenolic extract attenuates fatty acid-induced steatosis and oxidative stress in hepatic and endothelial cells SO EUROPEAN JOURNAL OF NUTRITION LA English DT Article DE Non-alcoholic fatty liver disease; Atherosclerosis; Olive pomace; Phenolic compound; Oxidative stress ID OLIVE OIL; LIVER-DISEASE; NITRIC-OXIDE; CARDIOVASCULAR-DISEASE; DENSITY-LIPOPROTEIN; MEDITERRANEAN DIET; GENE-EXPRESSION; HEPATOCYTES; ANTIOXIDANT; ACTIVATION AB Phenolic compounds (PC) of virgin olive oil exert several biochemical and pharmacological beneficial effects. Some dietary PC seem to prevent/improve obesity and metabolic-related disorders such as non-alcoholic fatty liver disease (NAFLD). We investigated the possible effects of PC extracted from olive pomace (PEOP) and of the main single molecules present in the extract (tyrosol, apigenin, oleuropein, p-coumaric and caffeic acid) in protecting hepatocytes and endothelial cells against triglyceride accumulation and oxidative stress. Rat hepatoma and human endothelial cells were exposed to a mixture of oleate/palmitate to mimic the condition of NAFLD and atherosclerosis, respectively. Then, cells were incubated for 24 h in the absence or in the presence of PC or PEOP. Different parameters were evaluated, such as lipid accumulation and oxidative stress-related markers. In hepatic cells, expression of peroxisome proliferator-activated receptors (PPARs) and of stearoyl-CoA desaturase 1 (SCD-1) were assessed as index of lipid metabolism. In endothelial cells, expression of intercellular adhesion molecule-1 (ICAM-1), activation of nuclear factor kappa-B (NF-kB), release of nitric oxide (NO), and wound-healing rate were assessed as index of inflammation. PEOP extract ameliorated hepatic lipid accumulation and lipid-dependent oxidative imbalance thus showing potential applications as therapeutic agent tuning down hepatosteatosis and atherosclerosis. C1 [Vergani, Laura; Vecchione, Giulia; Baldini, Francesca; Grasselli, Elena; Voci, Adriana] Univ Genoa, Dept Earth Environm & Life Sci, Corso Europa 26, I-16132 Genoa, Italy. [Portincasa, Piero] Univ Bari, Dept Biomed Sci & Human Oncol, Bari, Italy. [Ferrari, Pier Francesco; Aliakbarian, Bahar; Casazza, Alessandro A.; Perego, Patrizia] Univ Genoa, Dept Civil Chem & Environm Engn, Genoa, Italy. C3 University of Genoa; Universita degli Studi di Bari Aldo Moro; University of Genoa RP Vergani, L (通讯作者)，Univ Genoa, Dept Earth Environm & Life Sci, Corso Europa 26, I-16132 Genoa, Italy. EM laura.vergani@unige.it RI Baldini, Francesca/AAQ-3685-2020; Ferrari, Pier/AAC-1278-2019; portincasa, piero/J-7245-2018; Casazza, Alessandro/JAC-6599-2023; Voci, Alberto/M-9733-2019; Grasselli, Elena/H-4304-2013 OI Baldini, Francesca/0000-0002-6284-436X; Perego, Patrizia/0000-0001-5904-2940; Grasselli, Elena/0000-0003-4439-4059 FU MIUR-COFIN [20089SRS2X_002]; Compagnia San Paolo Torino [2009.1824-1067/IT/pv]; University of Genova [2015]; European Joint Programming Initiative "A Healthy Diet for a Healthy Life (JPI HDHL)-National Project Wellness, Nutrition, Sport and Exercise prevention (WISE) 2013-16" FX This research was supported by grants from MIUR-COFIN (Prot. 20089SRS2X_002), Compagnia San Paolo Torino (Prat. No. 2009.1824-1067/IT/pv), University of Genova (no. 2015), European Joint Programming Initiative "A Healthy Diet for a Healthy Life (JPI HDHL)-National Project Wellness, Nutrition, Sport and Exercise prevention (WISE) 2013-16 (PP). 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J. Nutr. PD AUG PY 2018 VL 57 IS 5 BP 1793 EP 1805 DI 10.1007/s00394-017-1464-5 PG 13 WC Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Nutrition & Dietetics GA GN3SL UT WOS:000438928300008 PM 28526925 OA Green Submitted DA 2026-02-02 ER PT J AU Wang, C Shang, YY Kanaan, G Chai, L Li, H Qi, XS AF Wang, Caie Shang, Yiyang Kanaan, Ghid Chai, Lu Li, Hui Qi, Xingshun TI Silymarin for adults with metabolic dysfunction-associated steatotic liver disease SO COCHRANE DATABASE OF SYSTEMATIC REVIEWS LA English DT Review ID NONALCOHOLIC FATTY LIVER; TRIAL SEQUENTIAL-ANALYSIS; E-PHOSPHOLIPID COMPLEX; VITAMIN-E; OVERWEIGHT PATIENTS; MEDITERRANEAN DIET; DOUBLE-BLIND; STEATOHEPATITIS; METAANALYSIS; MANAGEMENT AB Rationale Metabolic dysfunction-associated steatotic liver disease (MASLD) is a major public health challenge, with approximately 32.4% of adults globally diagnosed with the condition and a steadily increasing prevalence. Currently, no specific medicines are approved to manage MASLD effectively. Silymarin, a common herbal agent with antioxidant, anti-inflammatory, and antifibrotic properties, presents potential therapeutic benefits for MASLD in both its monotherapy and complex forms (complexation with solubilising agents, such as vitamin E, phosphatidyl choline, etc.). Objectives To evaluate the benefits and harms of silymarin monotherapy and silymarin complex in adults with MASLD. Search methods We searched CENTRAL, MEDLINE, Embase, LILACS, Web of Science, three Chinese regional bibliographic databases, and two trial registries; we also performed reference checking and contacted trial authors for relevant studies (search date: 15 May 2024). Eligibility criteria We included randomised clinical trials comparing silymarin monotherapy or silymarin complex versus no intervention, placebo, or other interventions in adults with MASLD. We excluded quasi-randomised and observational studies. There were no restrictions on the publication language, date, or status. Outcomes Critical outcomes were the proportion of people with serious adverse events, all-cause mortality, and quality of life. Some of the most important outcomes were liver enzymes (i.e. alanine transaminase (ALT), aspartate aminotransferase (AST), and gamma glutamyl transpeptidase (GGT)), and the proportion of people with adverse events considered non-serious. We analysed these outcomes at the end of treatment and during maximal follow-up. Risk of bias We assessed the risk of bias using the RoB 2 tool. Synthesis methods We conducted meta-analyses of available data at maximal follow-up, using the random-effects model as our primary analysis. We calculated risk ratio (RR) for dichotomous data and mean difference (MD) for continuous data, both with 95% confidence intervals (CI). For rare events, we used the Peto odds ratio (OR) and 95% CI. When meta-analysis was not feasible, we synthesised the data narratively. We used GRADE to assess the certainty of evidence for prespecified outcomes. Included studies We included 17 RCTs with 2069 participants having MASLD (78 participants were diagnosed with MASLD, 423 with metabolic-associated steatohepatitis (MASH), and the diagnosis of 1568 participants was not classified). Four trials were multicentre and 13 were single-centre trials. Twelve trials were conducted in Asia, four in Europe, and one in North America. Silymarin monotherapy (nine trials) and silymarin complex (eight trials) were compared with no intervention, placebo, or other interventions. The number of participants ranged from 36 to 494 (median: 90). Participants' mean age was 43.2 years with a mean proportion of males of 55.6% in the trials reporting on this. The follow-up ranged from four weeks to 48 weeks. Synthesis of results The evidence suggests that silymarin monotherapy versus no intervention or placebo may result in little to no difference in serious adverse events (Peto OR 1.55, 95% CI 0.26 to 9.28; 4 trials, 304 participants; low-certainty evidence). The evidence is very uncertain about the eJect of silymarin monotherapy versus no intervention or placebo on non-serious adverse events (RR 1.29, 95% CI 0.88 to 1.89; 4 trials, 282 participants; very low-certainty evidence). Silymarin monotherapy versus no intervention or placebo may decrease ALT (MD -7.21 U/ L, 95% CI -10.62 to -3.80; 6 trials, 409 participants; very low-certainty evidence) and GGT (MD -8.30 U/L, 95% CI -12.43 to -4.17; 1 trial, 45 participants; very low-certainty evidence), but the evidence is very uncertain. We did not perform a meta-analysis for AST due to considerable heterogeneity (I-2 = 77%). The evidence is very uncertain about the eJect of silymarin monotherapy versus other interventions on serious adverse events (Peto OR not estimable, no events observed; 1 trial, 45 participants; very low-certainty evidence), non-serious adverse events (RR 0.67, 95% CI 0.08 to 5.88; 1 trial, 45 participants; very low-certainty evidence), ALT (MD -0.89 U/L, 95% CI -3.78 to 2.00; 2 trials, 111 participants; very lowcertainty evidence), AST (MD 0.09 U/L, 95% CI -3.94 to 4.12; 2 trials, 111 participants; very low-certainty evidence), and GGT (MD 2.79 U/L, 95% CI -1.04 to 6.62; 1 trial, 45 participants; very low-certainty evidence). The evidence is very uncertain about the eJect of silymarin complex versus no intervention or placebo on serious adverse events (Peto OR not estimable, no events observed; 2 trials, 179 participants; very low-certainty evidence), ALT (MD -1.10 U/L, 95% CI -8.12 to 5.92; 4 trials, 309 participants; very low-certainty evidence), AST (MD 0.84 U/L, 95% CI -1.03 to 2.71; 4 trials, 309 participants; very low-certainty evidence), GGT (MD -1.21 U/L, 95% CI -6.76 to 4.35; 3 trials, 249 participants; very low-certainty evidence), and non-serious adverse events (RR 0.73, 95% CI 0.42 to 1.27; 2 trials, 157 participants; very low-certainty evidence). Silymarin complex versus other interventions probably results in little to no diJerence in serious adverse events (Peto OR not estimable, no events observed; 3 trials, 920 participants; moderate-certainty evidence). The evidence suggests that silymarin complex may result in little to no difference in GGT (MD 11.60 U/L, 95% CI -12.11 to 35.31; 1 trial, 126 participants; low-certainty evidence). We did not perform meta-analyses for ALT, AST, and non-serious adverse events due to considerable heterogeneity (I-2 = 77%, I-2 = 82%, and I-2 = 90%, respectively). None of the trials included in the comparisons reported all-cause mortality and quality of life. Authors' conclusions The benefits and harms of silymarin in adults with MASLD are unclear. Although one trial reported the occurrence of serious adverse events, none were deemed to be related to the study drugs. When compared with no intervention or placebo, silymarin monotherapy, rather than silymarin complex, may decrease liver enzymes. However, neither silymarin monotherapy nor silymarin complex showed a reduction in liver enzyme levels compared with other interventions. The certainty of evidence for these findings varied from low to very low due to insuJicient power, serious risk of bias, and moderate-to-substantial heterogeneity across studies. Well-designed clinical trials that consider people-related important clinical outcomes, such as all-cause mortality and quality of life, are needed. C1 [Wang, Caie; Shang, Yiyang; Chai, Lu; Li, Hui; Qi, Xingshun] Gen Hosp Northern Theater Command, Dept Gastroenterol, Shenyang, Peoples R China. [Wang, Caie; Shang, Yiyang; Chai, Lu; Li, Hui; Qi, Xingshun] Shenyang Pharmaceut Univ, Dept Life Sci & Biopharmaceut, Shenyang, Peoples R China. C3 Shenyang Pharmaceutical University RP Qi, XS (通讯作者)，Gen Hosp Northern Theater Command, Dept Gastroenterol, Shenyang, Peoples R China.; Qi, XS (通讯作者)，Shenyang Pharmaceut Univ, Dept Life Sci & Biopharmaceut, Shenyang, Peoples R China. 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PY 2025 IS 6 AR CD015524 DI 10.1002/14651858.CD015524.pub2 PG 55 WC Medicine, General & Internal WE Science Citation Index Expanded (SCI-EXPANDED) SC General & Internal Medicine GA 7AW4L UT WOS:001566657100001 PM 40552569 OA Green Accepted DA 2026-02-02 ER PT J AU Fogacci, F Rizzoli, E Giovannini, M Bove, M D'Addato, S Borghi, C Cicero, AFG AF Fogacci, Federica Rizzoli, Elisabetta Giovannini, Marina Bove, Marilisa D'Addato, Sergio Borghi, Claudio Cicero, Arrigo F. G. TI Effect of Dietary Supplementation with Eufortyn® Colesterolo Plus on Serum Lipids, Endothelial Reactivity, Indexes of Non-Alcoholic Fatty Liver Disease and Systemic Inflammation in Healthy Subjects with Polygenic Hypercholesterolemia: The ANEMONE Study SO NUTRIENTS LA English DT Article DE dietary supplement; nutraceutical compound; cholesterol; artichoke; bergamot ID NITRIC-OXIDE; ARTICHOKE; ARTERY; RISK AB We aimed to evaluate if dietary supplementation with a nutraceutical compound (Eufortyn (R) Colesterolo Plus) containing standardized bergamot polyphenolic fraction phytosome (Vazguard (R)), artichoke extract (Pycrinil (R)), artichoke dry extract. (Cynara scolymus L.), Q10 phytosome(Ubiqosome (R)) and zinc, could positively affect serum lipids concentration, systemic inflammation and indexes of non-alcoholic fatty liver disease (NAFLD) in 60 healthy subjects with polygenic hypercholesterolemia. Participants were adhering to a low-fat, low-sodium Mediterranean diet for a month before being randomly allocated to 8-week treatment with 1 pill each day of either Eufortyn (R) Colesterolo Plus or placebo. Dietary supplementation with Eufortyn (R) Colesterolo Plus was associated with significant improvement in total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), non-high-density lipoprotein cholesterol (non-HDL-C), high-sensitivity C-reactive protein (hs-CRP) and endothelial reactivity (ER) in comparison with baseline, and with significant reductions in waist circumference, TC, LDL-C, LDL-C/HDL-C, lipid accumulation product and fatty liver index compared to placebo. The study shows that dietary supplementation with standardized bergamot polyphenolic fraction phytosome, artichoke extracts, Q10 phytosome and zinc safely exerts significant improvements in serum lipids, systemic inflammation, indexes of NAFLD and endothelial reactivity in healthy subjects with moderate hypercholesterolemia. C1 [Fogacci, Federica; Rizzoli, Elisabetta; Giovannini, Marina; Bove, Marilisa; D'Addato, Sergio; Borghi, Claudio; Cicero, Arrigo F. G.] St Orsola Malpighi Univ Hosp, Hypertens & Cardiovasc Risk Res Ctr, Med & Surg Sci Dept, I-40138 Bologna, Italy. [Fogacci, Federica; Rizzoli, Elisabetta; Giovannini, Marina; Bove, Marilisa; D'Addato, Sergio; Borghi, Claudio; Cicero, Arrigo F. G.] IRCCS Policlin S Orsola Malpighi Bologna, I-40138 Bologna, Italy. [Fogacci, Federica; Cicero, Arrigo F. G.] Italian Nutraceut Soc SINut, I-40138 Bologna, Italy. C3 IRCCS Azienda Ospedaliero-Universitaria di Bologna RP Cicero, AFG (通讯作者)，St Orsola Malpighi Univ Hosp, Hypertens & Cardiovasc Risk Res Ctr, Med & Surg Sci Dept, I-40138 Bologna, Italy.; Cicero, AFG (通讯作者)，IRCCS Policlin S Orsola Malpighi Bologna, I-40138 Bologna, Italy.; Cicero, AFG (通讯作者)，Italian Nutraceut Soc SINut, I-40138 Bologna, Italy. EM federicafogacci@gmail.com; elisabetta.rizzoli@unibo.it; marina.giovannini3@unibo.it; marilisa.bove@aosp.bo.it; sergio.daddato@unibo.it; claudio.borghi@unibo.it; arrigo.cicero@unibo.it RI Giovannini, Marina/ITV-5674-2023; BORGHI, CLAUDIO/K-2032-2016; rizzoli, Elisabetta/HLQ-5757-2023; Fogacci, Federica/R-5931-2016; Cicero, Arrigo Francesco Giuseppe/H-8244-2019 OI D'ADDATO, Sergio/0000-0001-6631-4342; BORGHI, CLAUDIO/0000-0001-8039-8781; rizzoli, Elisabetta/0000-0002-6607-8009; Fogacci, Federica/0000-0001-7853-0042; Cicero, Arrigo Francesco Giuseppe/0000-0002-4367-3884 FU Scharper S.p.A. (Milano, MI, Italy) FX Products were manufactured and provided by Scharper S.p.A. (Milano, MI, Italy), who also fully funded the study. 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Its expression is influenced by numerous factors such as age, sex, body weight and adipose tissue content. However, dietary factors, i.e., diet structure and the percentage of individual nutrients and products, are very important modulators. Beneficial dietary habits are the Mediterranean diet, DASH diet, diet based on plant products and diet with reduced energy value. Moreover, the share of individual products and nutrients which increase the concentration of adiponectin is worth noting. This group may include monounsaturated fatty acids, polyunsaturated omega-3 fatty acids, dietary fiber, polyphenols, alcohol and milk products. Conversely, dietary ingredients which have a negative effect on the concentration of adiponectin are typical components of the Western diet: saturated fatty acids, trans fatty acids, monosaccharides and disaccharides, and red meat. Furthermore, a diet characterized by a high glycemic index such as a high-carbohydrate low-fat diet also seems to be unfavorable. Due to the fact that available knowledge should be systematized, this study aimed to summarize the most recent research on the influence of dietary factors on the concentration of adiponectin. C1 [Janiszewska, Justyna; Ostrowska, Joanna; Szostak-Wegierek, Dorota] Med Univ Warsaw, Fac Hlth Sci, Dept Clin Dietet, Ciolka Str 27, PL-01445 Warsaw, Poland. C3 Medical University of Warsaw RP Ostrowska, J (通讯作者)，Med Univ Warsaw, Fac Hlth Sci, Dept Clin Dietet, Ciolka Str 27, PL-01445 Warsaw, Poland. 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Moschonis, G Tierney, AC Itsiopoulos, C AF George, Elena S. Kucianski, Teagan Mayr, Hannah L. Moschonis, George Tierney, Audrey C. Itsiopoulos, Catherine TI A Mediterranean Diet Model in Australia: Strategies for Translating the Traditional Mediterranean Diet into a Multicultural Setting SO NUTRIENTS LA English DT Article DE Mediterranean diet; dietary intervention; diet; nutrition; translation; non-alcoholic fatty liver disease; cardiovascular disease ID CORONARY-HEART-DISEASE; HEALTH-BENEFITS; OLIVE OIL; CARDIOVASCULAR-DISEASE; OXIDATIVE STRESS; BLOOD-PRESSURE; WHOLE GRAINS; FATTY-ACIDS; RED WINE; CONSUMPTION AB Substantial evidence supports the effect of the Mediterranean Diet (MD) for managing chronic diseases, although trials have been primarily conducted in Mediterranean populations. The efficacy and feasibility of the Mediterranean dietary pattern for the management of chronic diseases has not been extensively evaluated in non-Mediterranean settings. This paper aims to describe the development of a MD model that complies with principles of the traditional MD applied in a multiethnic context. Optimal macronutrient and food-based composition was defined, and a two-week menu was devised incorporating traditional ingredients with evidence based on improvements in chronic disease management. Strategies were developed for the implementation of the diet model in a multiethnic population. Consistent with the principles of a traditional MD, the MD model was plant-based and high in dietary fat, predominantly monounsaturated fatty acids from extra virgin olive oil. Fruits, vegetables and wholegrains were a mainstay, and moderate amounts of nuts and seeds, fish, dairy and red wine were recommended. The diet encompassed key features of the MD including cuisine, biodiversity and sustainability. The MD model preserved traditional dietary components likely to elicit health benefits for individuals with chronic diseases, even with the adaptation to an Australian multiethnic population. C1 [George, Elena S.; Kucianski, Teagan; Mayr, Hannah L.; Moschonis, George; Tierney, Audrey C.; Itsiopoulos, Catherine] La Trobe Univ, Dept Rehabil Nutr & Sport, Hlth Sci 3,Kingsbury Dr, Bundoora, Vic 3086, Australia. [George, Elena S.] Deakin Univ, Sch Exercise & Nutr Sci, Bldg J,221 Burwood Hwy, Burwood, Vic 3125, Australia. [Tierney, Audrey C.] Univ Limerick, Sch Allied Hlth, Limerick V94 T9PX, Ireland. C3 La Trobe University; Deakin University; University of Limerick RP George, ES (通讯作者)，La Trobe Univ, Dept Rehabil Nutr & Sport, Hlth Sci 3,Kingsbury Dr, Bundoora, Vic 3086, Australia.; George, ES (通讯作者)，Deakin Univ, Sch Exercise & Nutr Sci, Bldg J,221 Burwood Hwy, Burwood, Vic 3125, Australia. EM Elena.George@deakin.edu.au; T.Kucianski@latrobe.edu.au; H.Mayr@latrobe.edu.au; G.Moschonis@latrobe.edu.au; A.Tierney@latrobe.edu.au; C.Itsiopoulos@latrobe.edu.au RI Tierney, Auey/AAB-7068-2022; George, Elena/J-3357-2019; Moschonis, George/AAM-9616-2021 OI Tierney, Auey/0000-0001-8562-2877; Mayr, Hannah L/0000-0001-7356-653X; George, Elena/0000-0002-1385-2371; Moschonis, George/0000-0003-3009-6675 FU Australian Government Research Training Program Scholarship FX This work was supported by an Australian Government Research Training Program Scholarship (ESG). 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The aim of this study is to evaluate the impact of current and lifelong alcohol consumption in patients with NAFLD. From 2015 to 2020, we enrolled 276 consecutive patients fulfilling criteria of NAFLD (alcohol consumption up to 140 g/week for women and 210 g/week for men). According to their current alcohol intake per week, patients were divided in: abstainers, very low consumers (C1: <70 g/week) and moderate consumers (C2). We created a new tool, called LACU (Lifetime Alcohol Consuming Unit) to estimate the alcohol exposure across lifetime: 1 LACU was defined as 7 alcohol units per week for 1 drinking year. Patients were divided into lifelong abstainers and consumers and the latter furtherly divided into quartiles: Q1-Q4. Stratification according to alcohol intake, both current and cumulative as estimated by LACU, showed that very low consumers (C1 and Q1-Q3) displayed lower frequency of cirrhosis and hepatocellular carcinoma compared to abstainers and moderate consumers (C2 and Q4). We can speculate that up to one glass of wine daily in the context of a Mediterranean diet may be a long-term useful approach in selected NAFLD patients. C1 [Ferri, Silvia; Stefanini, Bernardo; Mulazzani, Lorenzo; Alvisi, Margherita; Tovoli, Francesco; Leoni, Simona; Muratori, Luca; Granito, Alessandro; Piscaglia, Fabio] IRCCS Azienda Osped Univ Bologna, Div Internal Med Hepatobiliary & Immunoallerg Dis, I-40138 Bologna, Italy. [Stefanini, Bernardo; Mulazzani, Lorenzo; Alvisi, Margherita; Tovoli, Francesco; Muratori, Luca; Lotti, Tommaso; Granito, Alessandro; Bolondi, Luigi; Piscaglia, Fabio] Univ Bologna, Dept Med & Surg Sci, I-40126 Bologna, Italy. C3 IRCCS Azienda Ospedaliero-Universitaria di Bologna; University of Bologna RP Ferri, S (通讯作者)，IRCCS Azienda Osped Univ Bologna, Div Internal Med Hepatobiliary & Immunoallerg Dis, I-40138 Bologna, Italy. EM silvia.ferri@aosp.bo.it; bernardo.stefanini@studio.unibo.it; lorenzo.mulazzani2@studio.unibo.it; margherita.alvisi@studio.unibo.it; francesco.tovoli2@unibo.it; simona.leoni@aosp.bo.it; luca.muratori@studio.unibo.it; lottitommaso.med@gmail.com; alessandro.granito@unibo.it; luigi.bolondi@unibo.it; fabio.piscaglia@unibo.it RI ; TOVOLI, FRANCESCO/K-9027-2016; Piscaglia, Fabio/AAC-6899-2022; Granito, Alessano/G-9563-2013; Stefanini, Bernardo/GWQ-5807-2022; Lotti, Tommaso/R-3743-2016 OI Mulazzani, Lorenzo/0000-0003-3093-8289; Ferri, Silvia/0000-0002-6033-8594; TOVOLI, FRANCESCO/0000-0002-8350-1155; Piscaglia, Fabio/0000-0001-8264-1845; Granito, Alessano/0000-0002-0637-739X; Stefanini, Bernardo/0000-0003-3800-5678; CR Abdel-Rahman Omar, 2017, J Evid Based Med, V10, P245, DOI 10.1111/jebm.12270 Åberg F, 2018, HEPATOLOGY, V67, P2141, DOI 10.1002/hep.29631 Aberg F, 2020, HEPATOLOGY, V71, P835, DOI 10.1002/hep.30864 Ajmera VH, 2017, HEPATOLOGY, V65, P2090, DOI 10.1002/hep.29055 Angulo P, 2007, HEPATOLOGY, V45, P846, DOI 10.1002/hep.21496 Ascha MS, 2010, HEPATOLOGY, V51, P1972, DOI 10.1002/hep.23527 Becker U, 2002, HEPATOLOGY, V35, P868, DOI 10.1053/jhep.2002.32101 Bradley KA, 1998, J GEN INTERN MED, V13, P379, DOI 10.1046/j.1525-1497.1998.00118.x Chalasani N, 2018, HEPATOLOGY, V67, P328, DOI [10.1002/hep.29367, 10.1038/s42255-021-00344-4] Dallio M, 2021, INT J MOL SCI, V22, DOI 10.3390/ijms22010436 Davies MJ, 2002, JAMA-J AM MED ASSOC, V287, P2559, DOI 10.1001/jama.287.19.2559 Hagström H, 2017, SCAND J GASTROENTERO, V52, P159, DOI 10.1080/00365521.2016.1239759 Hayashi PH, 2004, AM J GASTROENTEROL, V99, P76, DOI 10.1046/j.1572-0241.2003.04013.x Herrmann E, 2018, HEPATOLOGY, V67, P260, DOI 10.1002/hep.29179 Holst C, 2017, DIABETOLOGIA, V60, P1941, DOI 10.1007/s00125-017-4359-3 Huang YJ, 2020, APPL PHYSIOL NUTR ME, V45, P227, DOI 10.1139/apnm-2019-0057 Imhof A, 2001, LANCET, V357, P763, DOI 10.1016/S0140-6736(00)04170-2 Izzo C, 2021, NUTRIENTS, V13, DOI 10.3390/nu13030933 Jarvis H, 2022, BMJ OPEN, V12, DOI 10.1136/bmjopen-2021-049767 Koppes LLJ, 2005, DIABETES CARE, V28, P719, DOI 10.2337/diacare.28.3.719 Kwon HK, 2014, LIVER INT, V34, P129, DOI 10.1111/liv.12230 Leoni S, 2018, WORLD J GASTROENTERO, V24, P3361, DOI 10.3748/wjg.v24.i30.3361 Li WQ, 2014, HEPATOLOGY, V60, P588, DOI 10.1002/hep.27160 Lonardo A, 2017, DIGEST LIVER DIS, V49, P471, DOI 10.1016/j.dld.2017.01.147 Loomba R, 2013, AM J EPIDEMIOL, V177, P333, DOI 10.1093/aje/kws252 Marchesini G, 2016, J HEPATOL, V64, P1388, DOI 10.1016/j.jhep.2015.11.004 Mitchell T, 2018, AM J GASTROENTEROL, V113, P1484, DOI 10.1038/s41395-018-0133-5 National Institute for Health and Care Excellence, NONALCOHOLIC FATTY L Petroni ML, 2019, NUTRIENTS, V11, DOI 10.3390/nu11123048 Ponziani FR, 2019, HEPATOLOGY, V69, P107, DOI 10.1002/hep.30036 Ronksley PE, 2011, BMJ-BRIT MED J, V342, DOI 10.1136/bmj.d671 Shabalala SC, 2020, BIOMED PHARMACOTHER, V131, DOI 10.1016/j.biopha.2020.110785 Sterling RK, 2006, HEPATOLOGY, V43, P1317, DOI 10.1002/hep.21178 Tovoli F, 2020, CURR PHARM DESIGN, V26, P3909, DOI 10.2174/1381612826666200429093648 Turati F, 2013, BRIT J CANCER, V108, P222, DOI 10.1038/bjc.2012.492 Wong VWS, 2018, J GASTROEN HEPATOL, V33, P70, DOI 10.1111/jgh.13857 Wood AM, 2018, LANCET, V391, P1513, DOI 10.1016/S0140-6736(18)30134-X Yi SW, 2018, CANCER-AM CANCER SOC, V124, P2748, DOI 10.1002/cncr.31406 Younossi ZM, 2015, HEPATOLOGY, V62, P1723, DOI 10.1002/hep.28123 NR 39 TC 8 Z9 11 U1 0 U2 4 PU MDPI PI BASEL PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND EI 2072-6643 J9 NUTRIENTS JI Nutrients PD JUN PY 2022 VL 14 IS 12 AR 2493 DI 10.3390/nu14122493 PG 17 WC Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Nutrition & Dietetics GA 2N1TO UT WOS:000818170700001 PM 35745223 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Esposito, K Giugliano, D AF Esposito, Katherine Giugliano, Dario TI Mediterranean Diet and the Metabolic Syndrome: The End of the Beginning SO METABOLIC SYNDROME AND RELATED DISORDERS LA English DT Review ID FATTY LIVER-DISEASE; ALANINE AMINOTRANSFERASE LEVELS; INSULIN-RESISTANT SUBJECTS; CARDIOVASCULAR RISK; RANDOMIZED-TRIAL; RICH DIET; CARBOHYDRATE; RESTRICTION; ADHERENCE; ADULTS AB The metabolic syndrome is now both a public health and a clinical problem. The most recent estimates from the National Health and Nutrition Examination Survey (NHANES) 2003-2006 reported that approximately 34% of adults in the United States have the metabolic syndrome. The relationship between adherence to a Mediterranean diet and the prevalence of metabolic syndrome has been explored in cross-sectional studies with discordant results. Two prospective studies with a follow up of 6 and 7.5 years show that subjects with the highest adherence to a Mediterranean diet had lower cumulative incidence of metabolic syndrome than those with the lowest adherence. Two interventional trials document a positive effect of a Mediterranean diet on reversal of metabolic syndrome. The Mediterranean diet may be also useful to ameliorate liver function tests in obese patients with insulin resistance and diabetes. There is no consensus as to what diet is the optimal one for patients who have the metabolic syndrome. A Mediterranean diet that is moderately lower in carbohydrate (45%), and moderately higher in fat (35-40%), with less than 10% of saturated fat, may be beneficial for ameliorating features of the metabolic syndrome, including effects on insulin sensitivity, blood lipids, and liver function. C1 [Esposito, Katherine] Univ Naples 2, Div Metab Dis, Dept Geriatr & Metab Dis, I-80138 Naples, Italy. C3 Universita della Campania Vanvitelli RP Esposito, K (通讯作者)，Univ Naples 2, Div Metab Dis, Dept Geriatr & Metab Dis, Piazza Miraglia, I-80138 Naples, Italy. 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PD JUN PY 2010 VL 8 IS 3 BP 197 EP 200 DI 10.1089/met.2009.0095 PG 4 WC Medicine, Research & Experimental WE Science Citation Index Expanded (SCI-EXPANDED) SC Research & Experimental Medicine GA 605BK UT WOS:000278322100002 PM 20158447 DA 2026-02-02 ER PT J AU Li, D Li, YJ Yang, SJ Lu, J Jin, X Wu, M AF Li, Dan Li, Yujuan Yang, Shengjie Lu, Jing Jin, Xiao Wu, Min TI Diet-gut microbiota-epigenetics in metabolic diseases: From mechanisms to therapeutics SO BIOMEDICINE & PHARMACOTHERAPY LA English DT Review DE Diet; Epigenetics; Gut microbiota; Microbiota-derived metabolites; Metabolic diseases ID HIGH-FAT-DIET; RANDOMIZED DOUBLE-BLIND; DNA METHYLATION; FIBER SUPPLEMENTATION; HISTONE MODIFICATIONS; MEDITERRANEAN DIET; INSULIN-RESISTANCE; BODY-COMPOSITION; IMPACT; ASSOCIATIONS AB The prevalence of metabolic diseases, including obesity, dyslipidemia, type 2 diabetes mellitus (T2DM), and nonalcoholic fatty liver disease (NAFLD), is a severe burden in human society owing to the ensuing high morbidity and mortality. Various factors linked to metabolic disorders, particularly environmental factors (such as diet and gut microbiota) and epigenetic modifications, contribute to the progression of metabolic diseases. Dietary components and habits regulate alterations in gut microbiota; in turn, microbiota-derived metabolites, such as short-chain fatty acids (SCFAs), are influenced by diet. Interestingly, diet-derived microbial metabolites appear to produce substrates and enzymatic regulators for epigenetic modifications (such as DNA methylation, histone modifications, and non-coding RNA expression). Epigenetic changes mediated by microbial metabolites participate in metabolic disorders via alterations in intestinal permeability, immune responses, inflammatory reactions, and insulin resistance. In addition, microbial metabolites can trigger inflammatory immune responses and microbiota dysbiosis by directly binding to G-protein-coupled receptors (GPCRs). 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Pharmacother. PD SEP PY 2022 VL 153 AR 113290 DI 10.1016/j.biopha.2022.113290 PG 15 WC Medicine, Research & Experimental; Pharmacology & Pharmacy WE Science Citation Index Expanded (SCI-EXPANDED) SC Research & Experimental Medicine; Pharmacology & Pharmacy GA 2J6UL UT WOS:000815789100009 PM 35724509 OA Green Submitted, gold HC Y HP N DA 2026-02-02 ER PT J AU Freer, CL George, ES Tan, SY Abbott, G Daly, RM AF Freer, Christine L. George, Elena S. Tan, Sze-Yen Abbott, Gavin Daly, Robin M. TI Delivery of a telehealth supported home exercise program with dietary advice to increase plant-based protein intake in people with non-alcoholic fatty liver disease: a 12-week randomised controlled feasibility trial SO BRITISH JOURNAL OF NUTRITION LA English DT Article DE Non-alcoholic fatty liver disease; Plant-based protein; Resistance exercise; Telehealth ID WEIGHT-LOSS; MEDITERRANEAN DIET; PHYSICAL-ACTIVITY; OVERWEIGHT; ADHERENCE; MARKERS; OBESITY; WHEY AB This study evaluated the feasibility and safety of a telehealth delivered exercise plus plant-based protein diet in adults with non-alcoholic fatty liver disease (NAFLD). This was a 12-week, randomised controlled feasibility trial including twenty-eight adults aged > 45 years with NAFLD randomised to a home muscle strengthening program (3 d/week) with increased protein intake (target similar to 12-15 g/kg/d) from predominately plant-based sources and behavioural change support (3-4 text messages/week) (Pro-Ex n 14) or usual care (UC, n 14). Feasibility was assessed via retention (<= 10 % attrition), adherence (exercise >= 66 %; recommended daily protein serves >= 80 %) and safety (adverse events). Secondary outcomes included macronutrient intake (3 x 24-h records), weight, moderate-to-vigorous physical activity (MVPA) and 30 s sit-to-stand (STS) performance. Study retention was 89 %. Mean exercise adherence (Pro-Ex) was 52 % with one adverse event from 241 sessions. In Pro-Ex, mean daily plant protein serves increased (09 to 14/d) and animal protein decreased (15 to 12/d) after 12-weeks, but overall adherence (serves/day) was 32[RD1] % (plant) and 42 % (animal). Relative to UC, Pro-Ex experienced a mean 27 (95 % CI: 09, 44) increase in 30 s STS number, 46-minute (95 % CI: -153, 245) increase in MVPA, 17 kg (95 % CI: -35, 02) decrease in weight, 352 g (95 % CI: 110, 593) increase in protein. In adults with NAFLD a telehealth home exercise and dietary intervention was safe and improved habitual plant and animal protein intake, but overall adherence was modest suggesting more intensive healthcare support may be required. C1 [Freer, Christine L.; George, Elena S.; Tan, Sze-Yen; Abbott, Gavin; Daly, Robin M.] Deakin Univ, Inst Phys Act & Nutr, Geelong, Australia. C3 Deakin University RP Freer, CL (通讯作者)，Deakin Univ, Inst Phys Act & Nutr, Geelong, Australia. EM cfree@deakin.edu.au RI George, Elena/J-3357-2019; Tan, Sze-Yen/H-5796-2019; Daly, Robin/AAN-2353-2020 OI Freer, CHRISTINE/0000-0003-2026-9931; Tan, Sze-Yen/0000-0002-9607-202X; FU Deakin University Higher Degree by Research Scholarship [DUPR 0000018830] FX C. L. F. was supported by a Deakin University Higher Degree by Research Scholarship (DUPR 0000018830). Deakin University had no role in the design, analysis or writing of the article. 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PD MAY 28 PY 2024 VL 131 IS 10 BP 1709 EP 1719 DI 10.1017/S0007114524000242 EA JAN 2024 PG 11 WC Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Nutrition & Dietetics GA XP9J5 UT WOS:001161892600001 PM 38268105 OA Green Submitted, hybrid DA 2026-02-02 ER PT J AU Sartorio, A Dal Pont, C Romano, S AF Sartorio, Andrea Dal Pont, Chiara Romano, Simone TI Standard and New Echocardio Techniques, Such as Global Longitudinal Strain, to Monitor the Impact of Diets on Cardiovascular Diseases and Heart Function SO NUTRIENTS LA English DT Review DE diet; echocardiography; cardiovascular disease; global longitudinal strain; hypertension; cardiovascular prevention; MASLD ID NONALCOHOLIC FATTY LIVER; LEFT-VENTRICULAR FUNCTION; MILD COGNITIVE IMPAIRMENT; VASCULAR RISK-FACTORS; MEDITERRANEAN DIET; TRACKING ECHOCARDIOGRAPHY; 2-DIMENSIONAL STRAIN; DIASTOLIC FUNCTION; INORGANIC NITRATE; MYOCARDIAL STRAIN AB "The Seven Countries Study", published in 1984, was the first study to find a correlation between diet and mortality related to cardiovascular diseases (CVDs). Since then, many investigations have addressed the relationship between type of diet, or specific nutrients, and CVDs. Based on these findings, some traditional dietary models, such as the Mediterranean or Nordic diet, are recommended to prevent CVDs. Meanwhile, new diets have been proposed for optimal nutrition therapy, for example, the Dietary Approaches to Stop Hypertension (DASH) and the Mediterranean-DASH Intervention Diet for Neurodegenerative Delay (MIND). The main outcomes evaluated after implementing these dietary models are as follows: CVD-related death; the development of specific CVDs, such as myocardial infarction and hypertension; or biochemical parameters related to CVDs, i.e., non-HDL cholesterol, C-reactive protein (CPR) and homocysteine. However, the early impact of diet on heart functionality is less evaluated. Recently, the echographic measurement of left ventricle (LV) deformation by global longitudinal strain (GLS) has been introduced as a novel marker of clinical and subclinical cardiac dysfunction. This technology allows a subclinical evaluation of heart functionality since, differently from the traditional evaluation of left ventricle ejection fraction (LVEF), it is capable of detecting early myocardial dysfunction. In this review, we analyzed the available studies that correlate dietetic regimens to cardiovascular diseases, focusing on the relevance of LV strain to detect subclinical myocardial alteration related to diet. Evidence is presented that DASH and MIND can have a positive impact on heart functionality and that myocardial strain is useful for early detection of diet-related changes in cardiac function. C1 [Sartorio, Andrea; Dal Pont, Chiara; Romano, Simone] Univ Verona, Dept Internal Med, Div Internal Med C, I-37134 Verona, Italy. 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Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND EI 2072-6643 J9 NUTRIENTS JI Nutrients PD MAY PY 2024 VL 16 IS 10 AR 1471 DI 10.3390/nu16101471 PG 12 WC Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Nutrition & Dietetics GA RY5B0 UT WOS:001231219800001 PM 38794710 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Roman, JH Patel, S AF Roman, Jose Hernandez Patel, Samarth TI Why Do Lifestyle Recommendations Fail in Most Patients with Nonalcoholic Fatty Liver Disease? SO GASTROENTEROLOGY CLINICS OF NORTH AMERICA LA English DT Article DE Nonalcoholic steatohepatitis; Weight loss; Diet; Lifestyle intervention ID WEIGHT-LOSS PROGRAM; PHYSICAL-ACTIVITY; MEDITERRANEAN DIET; LOW-CARBOHYDRATE; OBESE-PATIENTS; EXERCISE; INTERVENTION; FOOD; ADULTS; AMINOTRANSFERASE AB Nonalcoholic fatty liver disease has been recognized as a major health burden. The efficacy and safety profile of pharmacotherapy in the treatment of nonalcoholic fatty liver disease remains uncertain; therefore, lifestyle modification is the first line of treatment. Based on available data, patients should optimally achieve at least a 5% to 10% weight reduction for histologic improvement. There is no clear consensus on the optimal diet or exercise regimen. Sustainability of any intervention is key to success; however, compliance has been a major issue in clinical trials. This finding underscores the importance of multidisciplinary strategies to achieve targeted weigh loss. 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Clin. North Am. PD MAR PY 2020 VL 49 IS 1 BP 95 EP + DI 10.1016/j.gtc.2019.10.001 PG 11 WC Gastroenterology & Hepatology WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI) SC Gastroenterology & Hepatology GA KM6MF UT WOS:000514251500008 PM 32033766 DA 2026-02-02 ER PT J AU Hodson, L Rosqvist, F Parry, SA AF Hodson, Leanne Rosqvist, Fredrik Parry, Sion A. TI The influence of dietary fatty acids on liver fat content and metabolism SO PROCEEDINGS OF THE NUTRITION SOCIETY LA English DT Article; Proceedings Paper CT Winter Meeting of the Nutrition-Society / Conference on Optimal Diet and Lifestyle Strategies for the Management of Cardio-Metabolic Risk / Symposium 2 on Impact of Dietary Fatty Acids on Key Metabolic Tissues (Fat Depots and Muscle) CY DEC 04-05, 2018 CL Royal Soc Med, London, ENGLAND SP Nutr Soc HO Royal Soc Med DE Liver fat; Dietary; SFA; PUFA ID DE-NOVO LIPOGENESIS; HEPATIC INSULIN SENSITIVITY; RANDOMIZED CONTROLLED-TRIAL; MEDITERRANEAN DIET; RESONANCE SPECTROSCOPY; DOCOSAHEXAENOIC ACID; SUBSTRATE OXIDATION; RACIAL-DIFFERENCES; ADIPOSE-TISSUE; OLIVE OIL AB Non-alcoholic fatty liver disease encompasses a spectrum of conditions from hepatic steatosis through to cirrhosis; obesity is a known risk factor. The liver plays a major role in regulating fatty acid metabolism and perturbations in intrahepatic processes have potential to impact on metabolic health. It remains unclear why intra-hepatocellular fat starts to accumulate, but it likely involves an imbalance between fatty acid delivery to the liver, fatty acid synthesis and oxidation within the liver and TAG export from the liver. As man spends the majority of the day in a postprandial rather than postabsorptive state, dietary fatty acid intake should be taken into consideration when investigating why intra-hepatic fat starts to accumulate. This review will discuss the impact of the quantity and quality of dietary fatty acids on liver fat accumulation and metabolism, along with some of the potential mechanisms involved. Studies investigating the role of dietary fat in liver fat accumulation, although surprisingly limited, have clearly demonstrated that it is total energy intake, rather than fat intake per se, that is a key mediator of liver fat content; hyperenergetic diets increase liver fat whilst hypoenergetic diets decrease liver fat content irrespective of total fat content. Moreover, there is now, albeit limited evidence emerging to suggest the composition of dietary fat may also play a role in liver fat accumulation, with diets enriched in saturated fat appearing to increase liver fat content to a greater extent when compared with diets enriched in unsaturated fats. C1 [Hodson, Leanne; Rosqvist, Fredrik; Parry, Sion A.] Univ Oxford, Churchill Hosp, Oxford Ctr Diabet Endocrinol & Metab, Oxford OX3 7LE, England. [Rosqvist, Fredrik] Uppsala Univ, Dept Publ Hlth & Caring Sci, Clin Nutr & Metab, Uppsala, Sweden. C3 University of Oxford; Uppsala University RP Hodson, L (通讯作者)，Univ Oxford, Churchill Hosp, Oxford Ctr Diabet Endocrinol & Metab, Oxford OX3 7LE, England. EM leanne.hodson@ocdem.ox.ac RI ; Parry, Sion/AAT-1625-2020; Rosqvist, Fredrik/K-8975-2019 OI Hodson, Leanne/0000-0002-2648-6526; Parry, Sion/0000-0002-9037-1619; FU Henning and Johan Throne-Holsts Foundation; Swedish Society for Medical Research; Swedish Society of Medicine; The Foundation Blanceflor; BBSRC [BB/N005600/1] Funding Source: UKRI; Biotechnology and Biological Sciences Research Council [BBS/E/F/000PR10347] Funding Source: researchfish; British Heart Foundation [FS/15/56/31645] Funding Source: researchfish FX L. H. is a British Heart Foundation Senior Research Fellow in Basic Science. F. R. is supported by Henning and Johan Throne-Holsts Foundation, Swedish Society for Medical Research, Swedish Society of Medicine and The Foundation Blanceflor. 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Nutr. Soc. PD FEB PY 2020 VL 79 IS 1 BP 30 EP 41 AR PII S0029665119000569 DI 10.1017/S0029665119000569 PG 12 WC Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S) SC Nutrition & Dietetics GA KG1VO UT WOS:000509729300005 PM 30942685 OA Green Submitted, Bronze DA 2026-02-02 ER PT J AU Tur, K AF Tur, Kagan TI YouTube as a Source of Information for Dietary Guidance and Advisory Content in the Management of Non-Alcoholic Fatty Liver Disease SO HEALTHCARE LA English DT Article DE fatty liver disease; YouTube; dietary advice; nutrition; online health information ID HEALTH INFORMATION; WEIGHT-LOSS; QUALITY; VIDEOS; NAFLD AB Background/Objectives: Fatty liver disease (FLD), particularly non-alcoholic fatty liver disease (NAFLD), is a growing global health concern that underscores the need for effective dietary management strategies. With over 25% of patients seeking dietary advice through platforms like YouTube, the quality and reliability of this information remain critical. However, the disparity in educational value and engagement metrics between professional and non-professional content remains underexplored. This study evaluates YouTube's role in disseminating dietary advice for FLD management, focusing on content reliability, engagement metrics, and the educational value of videos. Methods: This cross-sectional study systematically analyzed 183 YouTube videos on FLD and dietary advice. Videos were selected based on relevance, English language, and non-promotional content. Scoring systems, including DISCERN, Global Quality Score (GQS), and the Video Information and Quality Index (VIQI), were employed to assess reliability, quality, and educational value. Engagement metrics such as views, likes, dislikes, and interaction rates were analyzed across uploader categories, including healthcare professionals, patients, and undefined sources. Results: Videos uploaded by healthcare professionals demonstrated significantly higher DISCERN scores (4.2 +/- 0.8) and GQS ratings (4.1 +/- 0.6) compared to patient-generated content (DISCERN: 2.8 +/- 0.9; GQS: 3.0 +/- 0.7). However, patient-generated videos achieved higher engagement rates, with median views reaching 340,000 (IQR: 15,000-1,000,000) compared to 450,050 (IQR: 23,000-1,800,000) for professional videos. Nutritional recommendations spanned diverse approaches, including low-carb diets, Mediterranean diets, and guidance to avoid processed foods and sugars. A significant proportion of videos lacked evidence-based content, particularly among non-professional uploads. Conclusions: YouTube represents a widely accessed but inconsistent source of dietary advice for FLD. While healthcare professional videos exhibit higher reliability and educational value, patient-generated content achieves broader engagement, revealing a critical gap in trusted, accessible dietary guidance. These findings highlight the need for clinicians and content creators to collaborate in curating and disseminating evidence-based content, ensuring patients receive accurate, actionable advice for managing FLD. C1 [Tur, Kagan] Ahi Evran Univ, Fac Med, Internal Med Dept, TR-40200 Kirsehir, Turkiye. C3 Kirsehir Ahi Evran University RP Tur, K (通讯作者)，Ahi Evran Univ, Fac Med, Internal Med Dept, TR-40200 Kirsehir, Turkiye. EM kaantur542@gmail.com RI Tur, Kağan/IAQ-4145-2023 OI Tur, Kağan/0000-0001-5989-2099 CR Abenavoli L, 2014, WORLD J GASTROENTERO, V20, P16831, DOI 10.3748/wjg.v20.i45.16831 Albayrak E, 2023, ANGLE ORTHOD, V93, P409, DOI 10.2319/042522-315.1 Alferink L.J., 2018, J. 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Several studies relate weight loss in obese patients to improved anthropometric measurements and cardiometabolic risk. The objective of our study was to evaluate anthropometric changes, analytical parameters, insulin resistance, fatty liver, and metabolic scales, after a personalized weight loss program, through dietary advice to increase adherence to the Mediterranean diet and a motivational booster via mobile SMS messaging. Methods: Intervention study on a sample of 1964 workers, in which different anthropometric parameters were evaluated before and after dietary intervention: the metabolic score of insulin resistance; non-alcoholic fatty liver disease using different scales; metabolic syndrome; atherogenic dyslipidemia; and the cardiometabolic index. A descriptive analysis of the categorical variables was performed, by calculating the frequency and distribution of the responses for each one. For quantitative variables, the mean and standard deviation were calculated, since they followed a normal distribution. Bivariate association analysis was performed by applying the chi-squared test (corrected by Fisher's exact statistic when conditions required it) and Student's t-test for independent samples (for comparison of means). Results: The population subjected to the Mediterranean diet improved in all the variables evaluated at 12 months of follow-up and compliance with the diet. Conclusions: Dietary advice on a Mediterranean diet and its reinforcement with reminder messages through the use of mobile phones may be useful to improve the parameters evaluated in this study and reduce the cardiometabolic risk of patients. C1 [Ignacio Ramirez-Manent, Jose] Univ Balearic Isl, Fac Med, Palma De Mallorca 07009, Spain. [Ignacio Ramirez-Manent, Jose; Arturo Lopez-Gonzalez, Angel] Balearic Isl Hlth Res Inst Fdn, IDISBA, Palma De Mallorca 07004, Spain. [Ignacio Ramirez-Manent, Jose] Balearic Isl Hlth Serv, Gen Practitioner Dept, Palma De Mallorca 07003, Spain. [Ignacio Ramirez-Manent, Jose; Tomas-Gil, Pilar; Marti-Lliteras, Pau; Coll Villalonga, Josep Lluis; Martinez-Almoyna Rifa, Emilio; Arturo Lopez-Gonzalez, Angel] Invest Grp ADEMA SALUD IUNICS, Palma De Mallorca 07003, Spain. [Arturo Lopez-Gonzalez, Angel] Univ Sch ADEMA, Fac Dent, Palma De Mallorca 07009, Spain. C3 Universitat de les Illes Balears; Institut Investigacio Sanitaria Illes Balears (IdISBa) RP Tomás-Gil, P (通讯作者)，Invest Grp ADEMA SALUD IUNICS, Palma De Mallorca 07003, Spain. 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English DT Article ID DIETARY ANTIOXIDANTS; MEDITERRANEAN DIET; COLORECTAL ADENOMA; PROSTATE-CANCER; UNITED-STATES; VITAMIN-C; RISK; STRESS; SMOKING; ASSOCIATION AB Evidence has also shown that oxidative stress and systemic inflammation, or in other words, disruption of the oxidant and antioxidant balance, can play an important role in the initiation or progression of NAFLD. The purpose of this study was to investigate the associations between the oxidative balance scores (OBS) and the risk of NAFLD. 552 healthy and 340 patients adult over the age of 18 with NAFLD participated in this case-control research. A validated 168-item quantitative food frequency questionnaire (FFQ) and indicators of physical activity, obesity, and smoking status were used to assess OBS score. The connection between OBS and NAFLD was discovered using binary logistic regression. The mean (+/- SD) age and (body mass index) BMI of the study population was 40.22 +/- 9.79 years and 29.06 +/- 3.92 kg/m(2), respectively. The mean +/- SD of OBS was 41.48 +/- 5.23. After adjustment for potential confounders, higher scores of adherence to the OBS conferred a protection for the presence of NAFLD (odds ratio [OR]: 0.29; 95% confidence interval [CI]: 0.15-0.49; P for trend < 0.001). The findings of the present study indicate an approximately 80% reduction in the odds of developing NAFLD with higher OBS adherence in the overall population. However, prospective studies are needed to further investigate this association. C1 [Sohouli, Mohammad Hassan] Shahid Beheshti Univ Med Sci, Fac Nutr & Food Technol, Dept Clin Nutr & Dietet, Student Res Comm, Tehran, Iran. [Rohani, Pejman] Univ Tehran Med Sci, Childrens Med Ctr, Pediat Ctr Excellence, Pediat Gastroenterol & Hepatol Res Ctr, Tehran, Iran. [Hosseinzadeh, Mahdieh] Shahid Sadoughi Univ Med Sci, Sch Publ Hlth, Dept Nutr, Yazd, Iran. [Hekmatdoost, Azita] Shahid Beheshti Univ Med Sci, Natl Nutr & Food Technol Res Inst, Fac Nutr & Food Technol, Dept Clin Nutr & Dietet, 7 West Arghavan St Farahzadi Blvd POB 193954741, Tehran 1981619573, Iran. C3 Shahid Beheshti University Medical Sciences; Tehran University of Medical Sciences; Shahid Sadoughi University of Medical Sciences; Shahid Beheshti University Medical Sciences RP Hekmatdoost, A (通讯作者)，Shahid Beheshti Univ Med Sci, Natl Nutr & Food Technol Res Inst, Fac Nutr & Food Technol, Dept Clin Nutr & Dietet, 7 West Arghavan St Farahzadi Blvd POB 193954741, Tehran 1981619573, Iran. EM a_hekmat2000@yahoo.com RI hosseinzadeh, mahdieh/R-3531-2019; Rohani, Pejman/Q-3873-2019; Hekmatdoost, Azita/AGM-6497-2022 FU Student Research Committee of Shahid Beheshti University of Medical Sciences; Shahid Beheshti University of Medical Sciences FX We thank the Student Research Committee and the Research & Technology Chancellor of Shahid Beheshti University of Medical Sciences for their financial support of this study. 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Flavonoids, a class of polyphenolic compounds mainly contained in natural sources and in the foods of the Mediterranean diet, have emerged as potential candidates for liver protection due to their anti-inflammatory, antioxidant, and anti-fibrotic properties. Baicalein, derived from Scutellaria baicalensis, exhibits hepatoprotective effects by attenuating oxidative stress, inhibiting fibrogenesis, and modulating lipid metabolism. Galangin, a flavonoid derived from Alpinia officinarum, has demonstrated anti-inflammatory and anti-fibrotic properties, while isorhamnetin, a methylated flavonoid found in various fruits and herbs, has been shown to possess hepatoprotective qualities, as it reduces oxidative stress and mitigates inflammation in CLDs. This narrative review highlights the preventive and therapeutic potential of these three flavonoids, emphasizing their role as promising agents for managing CLDs and guiding future research. C1 [Scarlata, Giuseppe Guido Maria; Lopez, Ivo; Gambardella, Maria Luisa; Abenavoli, Ludovico] Magna Graecia Univ Catanzaro, Dept Hlth Sci, I-88100 Catanzaro, Italy. [Milanovic, Maja; Milic, Natasa] Univ Novi Sad, Fac Med Novi Sad, Dept Pharm, Hajduk Veljkova 3, Novi Sad 21000, Serbia. C3 Magna Graecia University of Catanzaro; University of Novi Sad RP Abenavoli, L (通讯作者)，Magna Graecia Univ Catanzaro, Dept Hlth Sci, I-88100 Catanzaro, Italy. EM giuseppeguidomaria.scarlata@unicz.it; ivo.lopez@studenti.unicz.it; marialuisa.gambardella@studenti.unicz.it; maja.milanovic@mf.uns.ac.rs; natasa.milic@mf.uns.ac.rs; l.abenavoli@unicz.it RI Milanović, Maja/JXN-5115-2024; MONTEBIANCO ABENAVOLI, Ludovico/J-4394-2019; Scarlata, Giuseppe Guido Maria/IQV-1440-2023 OI Milanović, Maja/0000-0003-4082-5480; MONTEBIANCO ABENAVOLI, Ludovico/0000-0002-5922-1524; Milić, Nataša/0000-0002-8595-6065; Scarlata, Giuseppe Guido Maria/0000-0002-7084-8264 CR Abenavoli L, 2023, BIOMEDICINES, V11, DOI 10.3390/biomedicines11071792 Alghamdi SS, 2022, PLANTS-BASEL, V11, DOI 10.3390/plants11040549 Athanasopoulou F, 2023, NANOMEDICINE-UK, V18, DOI 10.2217/nnm-2022-0261 Bacanli M., 2018, Polyphenols: Prevention and Treatment of Human Disease, P433 Banjarnahor SDS, 2014, MED J INDONES, V23, P239, DOI 10.13181/mji.v23i4.1015 Bogoyavlenskiy A, 2023, ACS OMEGA, V8, P48499, DOI 10.1021/acsomega.3c08407 Capasso R, 2003, LIFE SCI, V72, P2993, DOI 10.1016/S0024-3205(03)00232-7 Chien ST, 2015, CANCER CELL INT, V15, DOI 10.1186/s12935-015-0168-2 Chowdhury S, 2021, SPECTROCHIM ACTA A, V246, DOI 10.1016/j.saa.2020.119008 Del Bo' C, 2023, NUTRIENTS, V15, DOI 10.3390/nu15102250 Devarbhavi H, 2023, J HEPATOL, V79, P516, DOI 10.1016/j.jhep.2023.03.017 Du Toit K, 2009, S AFR J SCI, V105, P470 Duan DZ, 2024, J FUNCT FOODS, V122, DOI 10.1016/j.jff.2024.106506 Eumkeb G, 2010, PHYTOMEDICINE, V18, P40, DOI 10.1016/j.phymed.2010.09.003 Ganbold M, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-52736-y Gao YX, 2023, PHYTOTHER RES, V37, P2405, DOI 10.1002/ptr.7762 Gong G, 2020, BIOMED PHARMACOTHER, V128, DOI 10.1016/j.biopha.2020.110301 Guan XL, 2023, BMC COMPLEMENT MED, V23, DOI 10.1186/s12906-023-03903-2 Guo HX, 2009, ACTA PHARMACOL SIN, V30, P1505, DOI 10.1038/aps.2009.150 Hasnat H, 2024, HELIYON, V10, DOI 10.1016/j.heliyon.2024.e27533 Heo MY, 2001, MUTAT RES-REV MUTAT, V488, P135, DOI 10.1016/S1383-5742(01)00054-0 Hu QC, 2021, PHARMACOL RES, V165, DOI 10.1016/j.phrs.2021.105444 Huang T, 2019, EUR J DRUG METAB PH, V44, P159, DOI 10.1007/s13318-018-0509-3 La XQ, 2024, FOODS, V13, DOI 10.3390/foods13193076 Li P, 2022, FRONT PHARMACOL, V13, DOI 10.3389/fphar.2022.925349 Li S, 2018, OXID MED CELL LONGEV, V2018, DOI 10.1155/2018/8394818 Liu N, 2019, MEDIAT INFLAMM, V2019, DOI 10.1155/2019/6175091 Liu SJ, 2023, FRONT MICROBIOL, V13, DOI 10.3389/fmicb.2022.1051100 Liu WJ, 2025, PHYTOTHER RES, V39, P1663, DOI 10.1002/ptr.8010 Miryan M, 2023, FRONT NUTR, V10, DOI 10.3389/fnut.2023.1062008 Munjal K, 2024, DRUG TARGET INSIGHT, V18, P30, DOI 10.33393/dti.2024.2707 Niu CG, 2024, MED ONCOL, V41, DOI 10.1007/s12032-024-02353-1 Paravati MR, 2024, HEPATOMA RES, V10, DOI 10.20517/2394-5079.2024.86 Paravati MR, 2024, NUTRIENTS, V16, DOI 10.3390/nu16081226 Park BB, 2019, SCI REP-UK, V9, DOI 10.1038/s41598-019-44853-5 Procopio AC, 2024, HEPATOMA RES, V10, DOI 10.20517/2394-5079.2023.128 Rana A, 2022, J FOOD BIOCHEM, V46, DOI 10.1111/jfbc.14264 Rauter AP, 2018, PURE APPL CHEM, V90, P1429, DOI 10.1515/pac-2013-0919 Ray G, 2022, WORLD J GASTROENTERO, V28, P5818, DOI 10.3748/wjg.v28.i40.5818 Shen KZ, 2017, OXID MED CELL LONGEV, V2017, DOI 10.1155/2017/6169128 Shi HL, 2022, EUR J PHARMACOL, V934, DOI 10.1016/j.ejphar.2022.175270 Si WJ, 2021, NUTRIENTS, V13, DOI 10.3390/nu13113953 Soltani S, 2019, ADV NUTR, V10, P1029, DOI 10.1093/advances/nmz041 Stojic J, 2023, DIAGNOSTICS, V13, DOI 10.3390/diagnostics13182960 Sun WL, 2020, FOOD FUNCT, V11, P711, DOI [10.1039/C9FO02237F, 10.1039/c9fo02237f] Tang YH, 2006, BIOMED CHROMATOGR, V20, P1116, DOI 10.1002/bmc.655 Tanwar S, 2020, WORLD J GASTROENTERO, V26, P109, DOI 10.3748/wjg.v26.i2.109 Wang DB, 2023, PHYTOTHER RES, V37, P5700, DOI 10.1002/ptr.8013 Wang H, 2023, NUTRIENTS, V15, DOI 10.3390/nu15081947 Wang XH, 2013, ENVIRON TOXICOL PHAR, V36, P288, DOI 10.1016/j.etap.2013.04.004 Williams RJ, 2004, FREE RADICAL BIO MED, V36, P838, DOI 10.1016/j.freeradbiomed.2004.01.001 Wu XJ, 2018, INT J MOL MED, V41, P1992, DOI 10.3892/ijmm.2018.3427 Xie Y, 2014, FITOTERAPIA, V93, P216, DOI 10.1016/j.fitote.2014.01.013 Xiong YG, 2020, BIOL PHARM BULL, V43, P1634, DOI 10.1248/bpb.b20-00258 Yang JH, 2016, EUR J PHARMACOL, V783, P92, DOI 10.1016/j.ejphar.2016.04.042 Zhang JY, 2015, J CHROMATOGR B, V985, P91, DOI 10.1016/j.jchromb.2015.01.018 Zhang L, 2007, EUR J PHARM SCI, V31, P221, DOI 10.1016/j.ejps.2007.04.001 Zhang XX, 2020, DRUG DES DEV THER, V14, P3393, DOI 10.2147/DDDT.S258187 Zheng Y, 2024, PHARMACOL RES, V208, DOI 10.1016/j.phrs.2024.107381 NR 59 TC 5 Z9 6 U1 1 U2 6 PU MDPI PI BASEL PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND EI 1420-3049 J9 MOLECULES JI Molecules PD MAR 11 PY 2025 VL 30 IS 6 AR 1253 DI 10.3390/molecules30061253 PG 14 WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary WE Science Citation Index Expanded (SCI-EXPANDED) SC Biochemistry & Molecular Biology; Chemistry GA 0PG6Q UT WOS:001452768100001 PM 40142029 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Bavaro, DF Laghetti, P Poliseno, M De Gennaro, N Di Gennaro, F Saracino, A AF Bavaro, Davide Fiore Laghetti, Paola Poliseno, Mariacristina De Gennaro, Nicolo Di Gennaro, Francesco Saracino, Annalisa TI A Step Closer to the "Fourth 90": A Practical Narrative Review of Diagnosis and Management of Nutritional Issues of People Living with HIV SO DIAGNOSTICS LA English DT Review DE HIV; diabetes; cardiovascular disease; chronic kidney disease; liver disease; NASH; NAFLD; diagnosis; nutrition; nutrition management; PLWH ID HUMAN-IMMUNODEFICIENCY-VIRUS; FATTY LIVER-DISEASE; CHRONIC KIDNEY-DISEASE; ANTIRETROVIRAL THERAPY; CARDIOVASCULAR-DISEASE; INSULIN-RESISTANCE; IMMUNE ACTIVATION; INFECTED PATIENTS; MICROBIAL TRANSLOCATION; HEPATIC-ENCEPHALOPATHY AB The quality of life of people living with HIV (PLWH) has remarkably increased thanks to the introduction of combined antiretroviral therapy. Still, PLWH are exposed to an increased risk of cardiovascular diseases, diabetes, chronic kidney disease, and liver disease. Hence, the purpose of this review is to summarize the current knowledge about diagnosis and nutritional management with specific indication of macro and micronutrients intake for the main comorbidities of PLWH. In fact, a prompt diagnosis and management of lifestyle behaviors are fundamental steps to reach the "fourth 90 ". To achieve an early diagnosis of these comorbidities, clinicians have at their disposal algorithms such as the Framingham Score to assess cardiovascular risk; transient elastography and liver biopsy to detect NAFLD and NASH; and markers such as the oral glucose tolerance test and GFR to identify glucose impairment and renal failure, respectively. Furthermore, maintenance of ideal body weight is the goal for reducing cardiovascular risk and to improve diabetes, steatosis and fibrosis; while Mediterranean and low-carbohydrate diets are the dietetic approaches proposed for cardioprotective effects and for glycemic control, respectively. Conversely, diet management of chronic kidney disease requires different nutritional assessment, especially regarding protein intake, according to disease stage and eventually concomitant diabetes. C1 [Bavaro, Davide Fiore; Laghetti, Paola; De Gennaro, Nicolo; Di Gennaro, Francesco; Saracino, Annalisa] Univ Bari, Univ Hosp Policlin, Clin Infect Dis, I-70124 Bari, Italy. [Poliseno, Mariacristina] Policlin Riuniti, Infect Dis Unit, I-710121 Foggia, Italy. C3 Universita degli Studi di Bari Aldo Moro RP Bavaro, DF (通讯作者)，Univ Bari, Univ Hosp Policlin, Clin Infect Dis, I-70124 Bari, Italy. EM davidebavaro@gmail.com; paola.laghetti1991@libero.it; polisenomc@gmail.com; nico84degennaro@gmail.com; cicciodigennaro@yahoo.it; annalisa.saracino@uniba.it RI ; Poliseno, Mariacristina/HDN-8717-2022; Bavaro, Davide Fiore/HDO-7050-2022; Saracino, Annalisa/I-4102-2012 OI Di Gennaro, Francesco/0000-0003-3453-5647; Poliseno, Mariacristina/0000-0002-9896-489X; Laghetti, Paola/0000-0002-9026-4733; Bavaro, Davide Fiore/0000-0002-4833-7118; FU Gilead Sciences, Inc. FX This research was funded by unconditional research grant by Gilead Sciences, Inc [HIV Fellowship Gilead 2019, Italy]. 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(SCI-EXPANDED) SC General & Internal Medicine GA XL2ZN UT WOS:000728017400001 PM 34829394 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Herrera-Marcos, LV Martínez-Beamonte, R Arnal, C Barranquero, C Puente-Lanzarote, JJ Herrero-Continente, T Lou-Bonafonte, JM Gonzalo-Romeo, G Mocciaro, G Jenkins, B Surra, JC Rodríguez-Yoldi, MJ Burillo, JC Lasheras, R García-Gil, A Güemes, A Koulman, A Osada, J AF Herrera-Marcos, Luis, V Martinez-Beamonte, Roberto Arnal, Carmen Barranquero, Cristina Puente-Lanzarote, Juan J. Herrero-Continente, Tania Lou-Bonafonte, Jose M. Gonzalo-Romeo, Gonzalo Mocciaro, Gabriele Jenkins, Benjamin Surra, Joaquin C. Rodriguez-Yoldi, Maria J. Burillo, Juan Carlos Lasheras, Roberto Garcia-Gil, Agustin Guemes, Antonio Koulman, Albert Osada, Jesus TI Dietary squalene supplementation decreases triglyceride species and modifies phospholipid lipidomic profile in the liver of a porcine model of non-alcoholic steatohepatitis SO JOURNAL OF NUTRITIONAL BIOCHEMISTRY LA English DT Article DE Squalene; Swine; NASH; Lipidomic; Cardiolipin; Triglyceride; IL-12p40; Ceramide ID GENE-EXPRESSION ANALYSES; HEPATIC STEATOSIS; ANIMAL-MODEL; HIGH-FAT; MICE; PROTEOMICS; SIGNATURES AB Squalene is a key minor component of virgin olive oil, the main source of fat in the Mediterranean diet, and had shown to improve the liver metabolism in rabbits and mice. The present research was carried out to find out whether this effect was conserved in a porcine model of hepatic steatohepatitis and to search for the lipidomic changes involved. The current study revealed that a 0.5% squalene supplementation to a steatotic diet for a month led to hepatic accumulation of squalene and decreased triglyceride content as well as area of hepatic lipid droplets without influencing cholesterol content or fiber areas. However, ballooning score was increased and associated with the hepatic squalene content. Of forty hepatic transcripts related to lipid metabolism and hepatic steatosis, only citrate synthase and a non-coding RNA showed decreased expressions. The hepatic lipidome, assessed by liquid chromatography-mass spectrometry in a platform able to analyze 467 lipids, revealed that squalene supplementation increased ceramide, Cer(36:2), and phosphatidylcholine (PC[32:01, PC[33:01 and PC[34:01) species and decreased cardiolipin, CL(69:5), and triglyceride (TG[54:21, TG[55:01 and TG[55:21) species. Plasma levels of interleukin 12p40 increased in pigs receiving the squalene diet. The latter also modified plasma lipidome by increasing TG(58:12) and decreasing non-esterified fatty acid (FA 14:0, FA 16:1 and FA 18:0) species without changes in total NEFA levels. Together this shows that squalene-induced changes in hepatic and plasma lipidomic profiles, non-coding RNA and anti-inflammatory interleukin are suggestive of an alleviation of the disease despite the increase in the ballooning score. (c) 2022 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license ( http://creativecommons.org/licenses/by-nc-nd/4.0/ ) C1 [Herrera-Marcos, Luis, V; Martinez-Beamonte, Roberto; Barranquero, Cristina; Herrero-Continente, Tania; Osada, Jesus] Univ Zaragoza, Inst Invest Sanitaria Aragon, Fac Vet, Dept Bioquim & Biol Mol & Celular, Zaragoza, Spain. [Herrera-Marcos, Luis, V; Martinez-Beamonte, Roberto; Arnal, Carmen; Barranquero, Cristina; Lou-Bonafonte, Jose M.; Surra, Joaquin C.; Rodriguez-Yoldi, Maria J.; Osada, Jesus] Univ Zaragoza, Inst Agroalimentario Aragon, CITA, Zaragoza, Spain. [Arnal, Carmen] Univ Zaragoza, Inst Invest Sanitaria Aragon, Fac Vet, Dept Patol Anim, Zaragoza, Spain. [Puente-Lanzarote, Juan J.] Hosp Clin Univ Lozano Blesa, Serv Bioquim Clin, Zaragoza, Spain. [Lou-Bonafonte, Jose M.; Rodriguez-Yoldi, Maria J.] Univ Zaragoza, Inst Invest Sanitaria Aragon, Dept Farmacol Fisiol Med Legal & Forense, Zaragoza, Spain. [Gonzalo-Romeo, Gonzalo] Univ Zaragoza, Div Expt Anim, Serv Gen Apoyo Invest, Zaragoza, Spain. [Mocciaro, Gabriele; Jenkins, Benjamin; Koulman, Albert] Univ Cambridge, NIHR BRC Core Metabol & Lipid Lab, Addenbrookes Hosp, Cambridge, England. [Surra, Joaquin C.] Univ Zaragoza, Inst Invest Sanitaria Aragon, Escuela Politecn Super Huesca, Dept Prod Anim & Ciencia Alimentos, Zaragoza, Huesca, Spain. [Burillo, Juan Carlos; Lasheras, Roberto] Serv Seguridad Agroalimentaria, Lab Agroambiental, Direct Gen Alimentat & Fomento Agroalimentario, Zaragoza, Spain. [Garcia-Gil, Agustin; Guemes, Antonio] Univ Zaragoza, Inst Invest Sanitaria Aragon, Fac Med, Dept Cirugia, Zaragoza, Spain. [Martinez-Beamonte, Roberto; Arnal, Carmen; Barranquero, Cristina; Lou-Bonafonte, Jose M.; Surra, Joaquin C.; Rodriguez-Yoldi, Maria J.; Osada, Jesus] Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr, Madrid, Spain. C3 University of Zaragoza; University of Zaragoza; University of Zaragoza; Lozano Blesa University Clinical Hospital; University of Zaragoza; University of Zaragoza; University of Cambridge; Cambridge University Hospitals NHS Foundation Trust; Addenbrooke's Hospital; University of Zaragoza; University of Zaragoza; Instituto de Salud Carlos III; CIBER - Centro de Investigacion Biomedica en Red; CIBEROBN RP Osada, J (通讯作者)，Univ Zaragoza, Dept Biochem & Mol Biol, Vet Sch, Miguel Servet 177, E-50013 Zaragoza, Spain. EM josada@unizar.es RI Surra, Joaquín/G-1128-2014; Martinez-Beamonte, Roberto/E-4981-2016; Lou Bonafonte, José Manuel/E-8282-2014; Mocciaro, Gabriele/JGE-4248-2023; BARRANQUERO CORTES, CRISTINA/LSM-4589-2024; Koulman, Albert/B-2967-2009; Marcos, Luis/AAQ-3645-2020 OI , Gonzalo Gonzalo/0009-0008-6478-7857; Lou Bonafonte, José Manuel/0000-0001-9578-6525; Mocciaro, Gabriele/0000-0001-5392-0909; BARRANQUERO CORTES, CRISTINA/0000-0002-8442-8041; FU Ministerio de Economia y Competitividad-Fondo Europeo de Desarrollo Regional [SAF2016-75441-R]; Ministerio de Ciencia e Innovacion (MCIN/AEI) [PID2019-104915RB-I00]; ERDF A way of making Europe; European Union; Fondo Social Europeo-Gobierno de Aragon [B16_20R]; CIBER de Fi-siopatologia de la Obesidad y Nutricion (CIBEROBN) [CB06/03/1012]; Fondo Social Europeo-Gobierno de Aragon contract; BBSRC [BB/M027252/2] Funding Source: UKRI; Biotechnology and Biological Sciences Research Council [BB/M027252/2] Funding Source: researchfish FX We thank the University of Zaragoza Veterinary Hospital for their anesthesia support, the Servicio General de Apoyo a la Investi-gacion, Division of Experimentacion Animal, Universidad de Zaragoza for their help in maintaining the animals and Larisa Richardson for her lab support. This research was funded by grants from the Ministerio de Economia y Competitividad-Fondo Europeo de De-sarrollo Regional (SAF2016-75441-R), Ministerio de Ciencia e Inno-vacion (MCIN/AEI/10.13039/501100011033, PID2019-104915RB-I00), "ERDF A way of making Europe", by the European Union and the Fondo Social Europeo-Gobierno de Aragon (B16_20R). CIBER de Fi-siopatologia de la Obesidad y Nutricion (CIBEROBN, CB06/03/1012) is an initiative of ISCIII. L.V.H.M. was recipient of a Fondo Social Europeo-Gobierno de Aragon contract. 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Nutr. Biochem. PD FEB PY 2023 VL 112 AR 109207 DI 10.1016/j.jnutbio.2022.109207 EA DEC 2022 PG 12 WC Biochemistry & Molecular Biology; Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Biochemistry & Molecular Biology; Nutrition & Dietetics GA 7K4MY UT WOS:000905259900008 PM 36402249 OA Green Submitted, hybrid DA 2026-02-02 ER PT J AU Derakhshandeh-Rishehri, SM Heidari-Beni, M Eftekhari, MH AF Derakhshandeh-Rishehri, S. M. Heidari-Beni, M. Eftekhari, M. H. TI THE EFFECTS OF REALSIL (SILYBIN-PHOSPHOLIPID-VITAMIN E COMPLEX) ON LIVER ENZYMES IN PATIENTS WITH NON-ALCOHOLIC FATTY LIVER DISEASE (NAFLD) OR NON-ALCOHOLIC STEATO-HEPATITIS (NASH): A SYSTEMATIC REVIEW AND META-ANALYSIS OF RCTS SO ACTA ENDOCRINOLOGICA-BUCHAREST LA English DT Review DE vitamin E; Silybin; Alanine Transaminase; Aspartate Aminotransferases; gamma-Glutamyltransferase ID ALANINE AMINOTRANSFERASE LEVELS; MEDITERRANEAN DIET; EPIDEMIOLOGY; SILYMARIN; CHILDREN; OBESE AB Background. The aim of the present study was to systematically review the effects of Realsil (silybin-phospholipid-vitamin E complex) on liver enzymes in patients with NAFLD or NASH. Methods. We searched Web of Science, MEDLINE, Google Scholar, Cochrane Library, Science Direct, ProQuest, Scopus, and 1868 articles were found up to December 2018. Four studies that examined the effect of Realsil intake on liver enzymes among NAFLD or NASH patients were included. Exclusion criteria include - animal studies, studies with the design other than clinical trials, studies on non-adult individuals, studies that assess the effect of vitamin E, silybin, or phospholipid solely, studies that examined the effect of Realsil on other outcomes, or studies with insufficient data. Results. The analysis demonstrated that Realsil intake led to a significant decrease in Gamma-Glutamyl Transpeptidase (GGT) levels (standardized mean difference (SMD) =-0.37; 95% confidence interval (CI]): -0.68 to -0.06). Realsil intake non-significantly decrease alanine transaminase (ALT) levels (SMD=-1.02 U/L; 95% CI: -2.23 to 0.20) and non-significantly increase aspartate aminotransferase (AST) levels (SMD = 0.17 U/L; 95% CI: -0.26-0.61). Conclusion. Realsil intake was associated with a significantly decreased circulating GGT level without any significant effect on AST and ALT levels. C1 [Derakhshandeh-Rishehri, S. M.; Eftekhari, M. H.] Shiraz Univ Med Sci, Shiraz, Fars, Iran. [Heidari-Beni, M.] Isfahan Univ Med Sci, Child Growth & Dev Res Ctr, Res Inst Primordial Prevent Noncommunicable Dis, Esfahan, Iran. C3 Shiraz University of Medical Science; Isfahan University of Medical Sciences RP Eftekhari, MH (通讯作者)，Shiraz Univ Med Sci, Sch Nutr & Food Sci, Dept Clin Nutr, Shiraz 7134814336, Iran. EM h_eftekhari@yahoo.com RI Heidari-Beni, Motahar/I-2972-2018; Derakhshandeh-Rishehri, Seyedeh-Masomeh/G-7421-2017 OI Heidari-Beni, Motahar/0000-0001-5543-5536; Derakhshandeh-Rishehri, Seyedeh-Masomeh/0000-0002-3936-1490 CR Abenavoli L, 2015, EXPERT REV GASTROENT, V9, P519, DOI 10.1586/17474124.2015.1004312 Adams LA, 2003, AM J GASTROENTEROL, V98, P2348, DOI 10.1016/j.amjgastroenterol.2003.08.001 Aller R, 2015, EUR REV MED PHARMACO, V19, P3118 Aller R, 2018, REV ESP ENFERM DIG, V110, P634, DOI 10.17235/reed.2018.5602/2018 Argo CK, 2009, CLIN LIVER DIS, V13, P511, DOI 10.1016/j.cld.2009.07.005 Bedogni G, 2007, HEPATOLOGY, V46, P1387, DOI 10.1002/hep.21827 Bellentani S, 2010, DIGEST DIS, V28, P155, DOI 10.1159/000282080 Cacciapuoti F, 2013, WORLD J HEPATOL, V5, P109, DOI 10.4254/wjh.v5.i3.109 Chen GL, 2016, INT J MOL SCI, V17, DOI 10.3390/ijms17091379 Cicero AFG, 2018, NUTRIENTS, V10, DOI 10.3390/nu10091153 De Lorenzo A, 2010, CURR PHARM DESIGN, V16, P814, DOI 10.2174/138161210790883561 Di Sario A, 2003, J HEPATOL, V38, P76, DOI 10.1016/S0168-8278(03)80314-8 Farrell GC, 2006, HEPATOLOGY, V43, pS99, DOI 10.1002/hep.20973 Federico A, 2006, DIGEST LIVER DIS, V38, P789, DOI 10.1016/j.dld.2006.04.009 Federico A, 2017, IN VIVO, V31, P609, DOI 10.21873/invivo.11101 Fraser A, 2008, DIABETOLOGIA, V51, P1616, DOI 10.1007/s00125-008-1049-1 Greco M, 2014, MEDIAT INFLAMM, V2014, DOI 10.1155/2014/750860 Hajaghamohammadi AA, 2008, HEPAT MON, V8, P191 Hajiaghamohammadi AA, 2012, HEPAT MON, V12, DOI 10.5812/hepatmon.6099 Hoofnagle JH, 2013, ALIMENT PHARM THER, V38, P134, DOI 10.1111/apt.12352 Kim GH, 2015, CLIN MOL HEPATOL, V21, P379, DOI 10.3350/cmh.2015.21.4.379 Kim NC, 2003, ORG BIOMOL CHEM, V1, P1684, DOI 10.1039/b300099k Koenig G, 2015, DIS MARKERS, V2015, P1, DOI 10.1155/2015/818570 Langmead L, 2001, ALIMENT PHARM THER, V15, P1239, DOI 10.1046/j.1365-2036.2001.01053.x Lazo M, 2008, SEMIN LIVER DIS, V28, P339, DOI 10.1055/s-0028-1091978 Loguercio C, 2012, FREE RADICAL BIO MED, V52, P1658, DOI 10.1016/j.freeradbiomed.2012.02.008 Loguercio C, 2011, WORLD J GASTROENTERO, V17, P2288, DOI 10.3748/wjg.v17.i18.2288 Loria P, 2010, DIGEST LIVER DIS, V42, P272, DOI 10.1016/j.dld.2010.01.021 Nascimbeni F, 2013, J HEPATOL, V59, P859, DOI 10.1016/j.jhep.2013.05.044 Pietu F, 2012, CLIN RES HEPATOL GAS, V36, P146, DOI 10.1016/j.clinre.2011.10.011 Sanyal AJ, 2010, NEW ENGL J MED, V362, P1675, DOI 10.1056/NEJMoa0907929 Sass DA, 2005, DIGEST DIS SCI, V50, P171, DOI 10.1007/s10620-005-1267-z Sciacqua A, 2019, INTERN EMERG MED, V14, P77, DOI 10.1007/s11739-018-1951-6 Shiraishi M, 2019, DIABETOL METAB SYNDR, V11, DOI 10.1186/s13098-019-0408-z Socha P, 2009, J PEDIATR GASTR NUTR, V48, P587, DOI 10.1097/MPG.0b013e31818e04d1 Stiuso P, 2014, OXID MED CELL LONGEV, V2014, DOI 10.1155/2014/169216 Strauss RS, 1999, J PEDIATR-US, V134, P160, DOI 10.1016/S0022-3476(99)70409-9 Trappoliere M, 2005, Minerva Gastroenterol Dietol, V51, P193 Trouillas P, 2008, J PHYS CHEM A, V112, P1054, DOI 10.1021/jp075814h Tzima N, 2009, NUTR METAB, V6, DOI 10.1186/1743-7075-6-30 Volti GL, 2011, CARDIOVASC DIABETOL, V10, DOI 10.1186/1475-2840-10-62 NR 41 TC 10 Z9 11 U1 1 U2 7 PU EDITURA ACAD ROMANE PI BUCURESTI PA CALEA 13 SEPTEMBRIE NR 13, SECTOR 5, BUCURESTI 050711, ROMANIA SN 1841-0987 EI 1843-066X J9 ACTA ENDOCRINOL-BUCH JI Acta Endocrinol. PD APR-JUL PY 2020 VL 16 IS 2 BP 223 EP 231 DI 10.4183/aeb.2020.223 PG 9 WC Endocrinology & Metabolism WE Science Citation Index Expanded (SCI-EXPANDED) SC Endocrinology & Metabolism GA PC6LY UT WOS:000597111200015 PM 33029240 OA Green Submitted DA 2026-02-02 ER PT J AU Perdomo, CM Garcia-Fernandez, N Escalada, J AF Perdomo, Carolina M. Garcia-Fernandez, Nuria Escalada, Javier TI Diabetic Kidney Disease, Cardiovascular Disease and Non-Alcoholic Fatty Liver Disease: A New Triumvirate? SO JOURNAL OF CLINICAL MEDICINE LA English DT Review DE diabetic kidney disease; cardiovascular disease; non-alcoholic fatty liver disease ID ANGIOTENSIN-RECEPTOR BLOCKERS; LIFE-STYLE MODIFICATION; SIGNIFICANT FIBROSIS; MEDITERRANEAN DIET; REDUCES FEATURES; CONTROLLED-TRIAL; BLOOD-PRESSURE; WEIGHT-LOSS; STATIN USE; STEATOHEPATITIS AB Non-alcoholic fatty liver disease is a highly prevalent disease worldwide with a renowned relation to cardiovascular disease and chronic kidney disease. These diseases share a common pathophysiology including insulin resistance, oxidative stress, chronic inflammation, dysbiosis and genetic susceptibilities. Non-alcoholic fatty liver disease is especially prevalent and more severe in type 2 diabetes. Patients with non-alcoholic fatty liver disease should have liver fibrosis assessment in order to identify those at the highest risk of adverse outcomes so that appropriate management strategies can be implemented. Early diagnosis and treatment of non-alcoholic fatty liver disease could ameliorate the burden of cardiovascular disease and chronic kidney disease. C1 [Perdomo, Carolina M.; Escalada, Javier] Clin Univ Navarra, Dept Endocrinol & Nutr, Pamplona 31008, Spain. [Perdomo, Carolina M.; Garcia-Fernandez, Nuria; Escalada, Javier] IdiSNA Inst Invest Salud Navarra, Pamplona 31008, Spain. [Garcia-Fernandez, Nuria] Clin Univ Navarra, Dept Nephrol, Pamplona 31008, Spain. [Garcia-Fernandez, Nuria] Inst Salud Carlos III, Red Invest Renal REDINREN, Madrid 28029, Spain. [Escalada, Javier] Inst Salud Carlos III, CIBERObn CIBER Fisiopatol Obesidad & Nutr, Madrid 28029, Spain. C3 University of Navarra; University of Navarra; Instituto de Salud Carlos III; Instituto de Salud Carlos III; CIBER - Centro de Investigacion Biomedica en Red; CIBEROBN RP Garcia-Fernandez, N (通讯作者)，IdiSNA Inst Invest Salud Navarra, Pamplona 31008, Spain.; Garcia-Fernandez, N (通讯作者)，Clin Univ Navarra, Dept Nephrol, Pamplona 31008, Spain.; Garcia-Fernandez, N (通讯作者)，Inst Salud Carlos III, Red Invest Renal REDINREN, Madrid 28029, Spain. 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Clin. Med. PD MAY PY 2021 VL 10 IS 9 AR 2040 DI 10.3390/jcm10092040 PG 15 WC Medicine, General & Internal WE Science Citation Index Expanded (SCI-EXPANDED) SC General & Internal Medicine GA SC0IS UT WOS:000650367200001 PM 34068699 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Ravaut, G Légiot, A Bergeron, KF Mounier, C AF Ravaut, Gaetan Legiot, Alexandre Bergeron, Karl-F. Mounier, Catherine TI Monounsaturated Fatty Acids in Obesity-Related Inflammation SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES LA English DT Review DE monounsaturated fatty acids (MUFA); stearoyl-CoA desaturase-1 (SCD1); chronic inflammation; saturated fatty acid (SFA); metabolic syndrome ID ENDOPLASMIC-RETICULUM STRESS; NF-KAPPA-B; DEFICIENCY PROTECTS MICE; COA DESATURASE-1 GENE; C-REACTIVE PROTEIN; VIRGIN OLIVE OIL; INSULIN-RESISTANCE; METABOLIC SYNDROME; MEDITERRANEAN DIET; ADIPOSE-TISSUE AB Obesity is an important aspect of the metabolic syndrome and is often associated with chronic inflammation. In this context, inflammation of organs participating in energy homeostasis (such as liver, adipose tissue, muscle and pancreas) leads to the recruitment and activation of macrophages, which secrete pro-inflammatory cytokines. Interleukin-1 beta secretion, sustained C-reactive protein plasma levels and activation of the NLRP3 inflammasome characterize this inflammation. The Stearoyl-CoA desaturase-1 (SCD1) enzyme is a central regulator of lipid metabolism and fat storage. This enzyme catalyzes the generation of monounsaturated fatty acids (MUFAs)-major components of triglycerides stored in lipid droplets-from saturated fatty acid (SFA) substrates. In this review, we describe the molecular effects of specific classes of fatty acids (saturated and unsaturated) to better understand the impact of different diets (Western versus Mediterranean) on inflammation in a metabolic context. Given the beneficial effects of a MUFA-rich Mediterranean diet, we also present the most recent data on the role of SCD1 activity in the modulation of SFA-induced chronic inflammation. C1 [Ravaut, Gaetan; Legiot, Alexandre; Bergeron, Karl-F.; Mounier, Catherine] Univ Quebec Montreal UQAM, Dept Biol Sci, Mol Metab Lipids Lab, CERMO FC Res Ctr, Montreal, PQ H3C 3P8, Canada. C3 University of Quebec; University of Quebec Montreal RP Mounier, C (通讯作者)，Univ Quebec Montreal UQAM, Dept Biol Sci, Mol Metab Lipids Lab, CERMO FC Res Ctr, Montreal, PQ H3C 3P8, Canada. EM ravaut.gaetan@courrier.uqam.ca; legiot.alexandre@courrier.uqam.ca; bergeron.karl-frederik@uqam.ca; mounier.catherine@uqam.ca RI ; Mounier, Catherine/D-3690-2011 OI Ravaut, Gaetan/0000-0003-3309-3154; Bergeron, Karl-F/0000-0002-7215-9104 FU NSREC grant FX G.R. was supported by the foundation Lueur d'espoir pour Ayden and A.L. by a NSREC grant. 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PD JAN PY 2021 VL 22 IS 1 AR 330 DI 10.3390/ijms22010330 PG 22 WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary WE Science Citation Index Expanded (SCI-EXPANDED) SC Biochemistry & Molecular Biology; Chemistry GA PP9FC UT WOS:000606158500001 PM 33396940 OA Green Submitted, gold HC Y HP N DA 2026-02-02 ER PT J AU Son, D Kwon, YJ Lee, HS Kim, HM Lee, JW AF Son, Da-Hye Kwon, Yu-Jin Lee, Hye Sun Kim, Hyung-Mi Lee, Ji-Won TI Effects of a Calorie-Restricted Mediterranean-Style Diet on Plasma Lipids in Hypercholesterolemic South Korean Patients SO NUTRIENTS LA English DT Article DE mediterranean diet; dyslipidemia; cardiovascular risk; insulin resistance; chronic inflammation ID MONOUNSATURATED FATTY-ACIDS; ENDOTHELIAL FUNCTION; OLEIC-ACID; OLIVE OIL; RED WINE; INFLAMMATION; CHOLESTEROL; GLUCOSE; INTERVENTION; DISEASE AB The objective of this randomized cross-over trial was to evaluate the short term effects of a calorie-restricted Korean style Mediterranean diet (KMD) versus a calorie-restricted conventional diet on lipid profile and other metabolic parameters in hypercholesterolemic patients. Ninety-two patients with hypercholesterolemia were randomly assigned to two groups and switched to the other group following a 4-week intervention after a 2-week washout period. While participants during KMD intervention period received home delivery of two meals daily except for weekends, those during the control group were advised to consume a conventional diet. Total cholesterol, low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) significantly decreased in KMD group even after adjusting for age, sex, total energy intake changes, alcohol consumption, smoking status, and physical activity changes (all p < 0.05). Anthropometric parameters, white blood cell (WBC), fasting glucose, fasting insulin, HOMA-IR, and fatty liver index (FLI) also significantly decreased after KMD intervention (all p < 0.05). In addition, WBC, fasting glucose, total cholesterol, LDL-C and FLI were significantly decreased even after adjusting for weight reduction changes. Calorie-restricted KMD not only helps to treat dyslipidemia by improving the lipid parameters but also has beneficial effects on reducing cardiovascular risk by improving chronic inflammation, insulin resistance, and fatty liver.

C1 [Son, Da-Hye; Kwon, Yu-Jin; Lee, Ji-Won] Yonsei Univ, Dept Family Med, Coll Med, Seoul 03722, South Korea. [Lee, Hye Sun] Yonsei Univ, Dept Res Affairs, Biostat Collaborat Unit, Coll Med, Seoul 03722, South Korea. [Kim, Hyung-Mi] Dongduck Womens Univ, Dept Food & Nutr, Seoul 02748, South Korea. C3 Yonsei University; Yonsei University Health System; Yonsei University; Yonsei University Health System RP Lee, JW (通讯作者)，Yonsei Univ, Dept Family Med, Coll Med, Seoul 03722, South Korea. EM sonda@yuhs.ac; digda3@yuhs.ac; hslee1@yuhs.ac; veronykim@naver.com; indi5645@yuhs.ac RI KWON, YUJIN/ACB-8082-2022; Lee, Hye Sun/AAD-6757-2019 OI KWON, YUJIN/0000-0002-9021-3856; Son, Dahye/0000-0001-7464-996X; LEE, JI WON/0000-0002-2666-4249; Lee, Hye Sun/0000-0001-6328-6948 FU Technology Innovation Program [20002781]; Ministry of Trade, Industry and Energy (MOTIE, Korea); Korea Institute of Planning and Evaluation for Technology in Food, Agriculture and Forestry (IPET) through High Value-added Food Technology Development Program - Ministry of Agriculture, Food and Rural Affairs (MAFRA) [321030-5] FX This work was supported the Technology Innovation Program (grant number 20002781), the Ministry of Trade, Industry and Energy (MOTIE, Korea), and by Korea Institute of Planning and Evaluation for Technology in Food, Agriculture and Forestry (IPET) through High Value-added Food Technology Development Program funded by Ministry of Agriculture, Food and Rural Affairs (MAFRA) (grant number 321030-5). 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J. Madden, Angela M. Roberts, Danielle Chase, Thomas J. G. Freeman, Suzanne C. Cooper, Nicola J. Sutton, Alex J. Fritche, Dominic Milne, Elisabeth Jane Wright, Kathy Pavlov, Chavdar S. Davidson, Brian R. Tsochatzis, Emmanuel Gurusamy, Kurinchi Selvan TI Lifestyle modifications for nonalcohol-related fatty liver disease: a network meta-analysis (Review) SO COCHRANE DATABASE OF SYSTEMATIC REVIEWS LA English DT Review ID RANDOMIZED CONTROLLED-TRIAL; CALORIE-RESTRICTED DIET; TERM ENERGY RESTRICTION; 3RD NATIONAL-HEALTH; RISK-FACTORS; AEROBIC EXERCISE; WEIGHT-LOSS; RESISTANCE EXERCISE; MEDITERRANEAN DIET; INSULIN-RESISTANCE AB Background The prevalence of nonalcohol-related fatty liver disease (NAFLD) varies between 19% and 33% in different populations. NAFLD decreases life expectancy and increases the risks of liver cirrhosis, hepatocellular carcinoma, and requirement for liver transplantation. There is uncertainty surrounding the relative benefits and harms of various lifestyle interventions for people with NAFLD. Objectives To assess the comparative benefits and harms of different lifestyle interventions in the treatment of NAFLD through a network meta-analysis, and to generate rankings of the different lifestyle interventions according to their safety and efficacy. Search methods We searched CENTRAL, MEDLINE, Embase, Science Citation Index Expanded, Conference Proceedings Citation Index - Science, World Health Organization International Clinical Trials Registry Platform, and trials registers until February 2021 to identify randomised clinical trials in people with NAFLD. Selection criteria We included only randomised clinical trials (irrespective of language, blinding, or status) in people with NAFLD, whatever the method of diagnosis, age, and diabetic status of participants, or presence of non-alcoholic steatohepatitis (NASH). We excluded randomised clinical trials in which participants had previously undergone liver transplantation. Data collection and analysis We planned to perform a network meta-analysis with OpenBUGS using Bayesian methods and to calculate the differences in treatments using hazard ratios (HRs), odds ratios (ORs), and rate ratios (RaRs) with 95% credible intervals (CrIs) based on an available-participant analysis, according to National Institute of Health and Care Excellence Decision Support Unit guidance. However, the data were too sparse for the clinical outcomes. We therefore performed only direct comparisons (head-to-head comparisons) with OpenBUGS using Bayesian methods. Main results We included a total of 59 randomised clinical trials (3631 participants) in the review. All but two trials were at high risk of bias. A total of 33 different interventions, ranging from advice to supervised exercise and special diets, or a combination of these and no additional intervention were compared in these trials. The reference treatment was no active intervention. Twenty-eight trials (1942 participants) were included in one or more comparisons. The follow-up ranged from 1 month to 24 months. The remaining trials did not report any of the outcomes of interest for this review. The follow-up period in the trials that reported clinical outcomes was 2 months to 24 months. During this short follow-up period, clinical events related to NAFLD such as mortality, liver cirrhosis, liver decompensation, liver transplantation, hepatocellular carcinoma, and liver-related mortality were sparse. This is probably because of the very short follow-up periods. It takes a follow-up of 8 years to 28 years to detect differences in mortality between people with NAFLD and the general population. It is therefore unlikely that differences by clinical outcomes will be noted in trials with less than 5 years to 10 years of follow-up. In one trial, one participant developed an adverse event. There were no adverse events in any of the remaining participants in this trial, or in any of the remaining trials, which seemed to be directly related to the intervention. Authors' conclusions The evidence indicates considerable uncertainty about the effects of the lifestyle interventions compared with no additional intervention (to general public health advice) on any of the clinical outcomes after a short follow-up period of 2 months to 24 months in people with nonalcohol-related fatty liver disease. Accordingly, high-quality randomised clinical trials with adequate follow-up are needed. We propose registry-based randomised clinical trials or cohort multiple randomised clinical trials (a study design in which multiple interventions are trialed within large longitudinal cohorts of participants to gain efficiencies and align trials more closely to standard clinical practice), comparing aerobic exercise and dietary advice versus standard of care (exercise and dietary advice received as part of national health promotion). The reason for the choice of aerobic exercise and dietary advice is the impact of these interventions on indirect outcomes which may translate to clinical benefit. The outcomes in such trials should be mortality, health-related quality of life, decompensated liver cirrhosis, liver transplantation, and resource use measures including costs of intervention and decreased healthcare use after a minimum follow-up of eight years, to find meaningful differences in the clinically important outcomes. C1 [Buzzetti, Elena; Tsochatzis, Emmanuel] Royal Free Hosp, Sheila Sherlock Liver Ctr, London, England. [Buzzetti, Elena; Tsochatzis, Emmanuel] UCL Inst Liver & Digest Hlth, London, England. [Linden, Audrey; Best, Lawrence M. J.; Roberts, Danielle; Davidson, Brian R.; Gurusamy, Kurinchi Selvan] UCL, Div Surg & Intervent Sci, London, England. [Madden, Angela M.] Univ Hertfordshire, Sch Life & Med Sci, Hatfield, Herts, England. [Chase, Thomas J. G.] Homerton Univ Hosp NHS Fdn Trust, Dept Gen Surg, London, England. [Freeman, Suzanne C.; Cooper, Nicola J.; Sutton, Alex J.] Univ Leicester, Dept Hlth Sci, Leicester, Leics, England. [Fritche, Dominic] UCL Med Sch, London, England. [Milne, Elisabeth Jane] Coventry Univ, Ctr Trust Peace & Social Relat, Coventry, W Midlands, England. [Wright, Kathy] Copenhagen Univ Hosp, Rigshosp, Capital Reg Denmark, Ctr Clin Intervent Res,Copenhagen Trial Unit,Coch, Copenhagen, Denmark. [Pavlov, Chavdar S.; Gurusamy, Kurinchi Selvan] IM Sechenov First Moscow State Med Univ, Dept Therapy, Moscow, Russia. C3 University of London; University College London; UCL Medical School; Royal Free London NHS Foundation Trust; University of London; University College London; University of London; University College London; University of Hertfordshire; University of Leicester; University of London; University College London; Coventry University; Rigshospitalet; University of Copenhagen; Copenhagen University Hospital; Sechenov First Moscow State Medical University RP Gurusamy, KS (通讯作者)，UCL, Div Surg & Intervent Sci, London, England.; Gurusamy, KS (通讯作者)，IM Sechenov First Moscow State Med Univ, Dept Therapy, Moscow, Russia. EM k.gurusamy@ucl.ac.uk RI ; Pavlov, Chavdar/E-7020-2017; Gurusamy, Kurinchi/C-2082-2008; Buzzetti, Elena/AAC-1975-2019; Tsochatzis, Emmanuel/A-1651-2012; Linden, Audrey/AAT-8961-2021 OI Chase, Thomas/0000-0002-3445-7960; Pavlov, Chavdar/0000-0001-5031-9798; Gurusamy, Kurinchi/0000-0002-0313-9134; Cooper, Nicola/0000-0002-4486-2791; Buzzetti, Elena/0000-0002-4462-7935; Milne, Elisabeth-Jane/0000-0002-0771-7632; Best, Lawrence/0000-0003-1923-0896; Tsochatzis, Emmanuel/0000-0001-5069-2461; Sutton, Alexander/0000-0002-8934-9940; Madden, Angela/0000-0001-6353-6492; FU Medical Research Council [G1100160, G0700718] Funding Source: Medline; Medical Research Council [G1100160, G0700718] Funding Source: researchfish CR Abbate M, 2021, NUTRIENTS, V13, DOI 10.3390/nu13020629 El-Kader SMA, 2014, AFR HEALTH SCI, V14, P551, DOI 10.4314/ahs.v14i3.8 Abdelbasset WK, 2020, MEDICINE, V99, DOI 10.1097/MD.0000000000019471 Abdelbasset WK, 2019, MEDICINE, V98, DOI [10.1097/md.0000000000014918, 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PU WILEY PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1469-493X EI 1361-6137 J9 COCHRANE DB SYST REV JI Cochrane Database Syst Rev. PY 2021 IS 6 AR CD013156 DI 10.1002/14651858.CD013156.pub2 PG 150 WC Medicine, General & Internal WE Science Citation Index Expanded (SCI-EXPANDED) SC General & Internal Medicine GA TD9PD UT WOS:000669649600003 PM 34114650 OA Green Submitted, Bronze DA 2026-02-02 ER PT J AU Ditano-Vázquez, P Torres-Peña, JD Galeano-Valle, F Pérez-Caballero, AI Demelo-Rodríguez, P Lopez-Miranda, J Katsiki, N Delgado-Lista, J Alvarez-Sala-Walther, LA AF Ditano-Vazquez, Paola David Torres-Pena, Jose Galeano-Valle, Francisco Isabel Perez-Caballero, Ana Demelo-Rodriguez, Pablo Lopez-Miranda, Jose Katsiki, Niki Delgado-Lista, Javier Alvarez-Sala-Walther, Luis A. TI The Fluid Aspect of the Mediterranean Diet in the Prevention and Management of Cardiovascular Disease and Diabetes: The Role of Polyphenol Content in Moderate Consumption of Wine and Olive Oil SO NUTRIENTS LA English DT Review DE mediterranean diet; cardiovascular disease; diabetes; polyphenols; wine; olive oil ID CORONARY-HEART-DISEASE; NITRIC-OXIDE SYNTHASE; IMPROVES LIVER STEATOSIS; DECREASE BLOOD-PRESSURE; SMOOTH-MUSCLE-CELLS; KAPPA-B ACTIVATION; RED WINE; ALCOHOL-CONSUMPTION; ENDOTHELIAL FUNCTION; FATTY LIVER AB A growing interest has emerged in the beneficial effects of plant-based diets for the prevention of cardiovascular disease, diabetes and obesity. The Mediterranean diet, one of the most widely evaluated dietary patterns in scientific literature, includes in its nutrients two fluid foods: olive oil, as the main source of fats, and a low-to-moderate consumption of wine, mainly red, particularly during meals. Current mechanisms underlying the beneficial effects of the Mediterranean diet include a reduction in inflammatory and oxidative stress markers, improvement in lipid profile, insulin sensitivity and endothelial function, as well as antithrombotic properties. Most of these effects are attributable to bioactive ingredients including polyphenols, mono- and poly-unsaturated fatty acids. Polyphenols are a heterogeneous group of phytochemicals containing phenol rings. The principal classes of red wine polyphenols include flavonols (quercetin and myricetin), flavanols (catechin and epicatechin), anthocyanin and stilbenes (resveratrol). Olive oil has at least 30 phenolic compounds. Among them, the main are simple phenols (tyrosol and hydroxytyrosol), secoroids and lignans. The present narrative review focuses on phenols, part of red wine and virgin olive oil, discussing the evidence of their effects on lipids, blood pressure, atheromatous plaque and glucose metabolism. C1 [Ditano-Vazquez, Paola; Galeano-Valle, Francisco; Demelo-Rodriguez, Pablo; Alvarez-Sala-Walther, Luis A.] Hosp Gen Univ Gregorio Maranon, Internal Med, Madrid 28007, Spain. [David Torres-Pena, Jose; Isabel Perez-Caballero, Ana; Lopez-Miranda, Jose; Delgado-Lista, Javier] Univ Cordoba, Reina Sofia Univ Hosp, Maimonides Biomed Res Inst Cordoba IMIBIC, Lipids & Atherosclerosis Unit,Dept Internal Med, Av Menendez Pidal S-N, Cordoba 14004, Spain. [David Torres-Pena, Jose; Isabel Perez-Caballero, Ana; Lopez-Miranda, Jose; Delgado-Lista, Javier] ISCIII, CIBER Fisiopatol Obesidad & Nutr CIBEROBN, Madrid 28007, Spain. [Galeano-Valle, Francisco; Demelo-Rodriguez, Pablo; Alvarez-Sala-Walther, Luis A.] Inst Invest Sanitaria Gregorio Maranon, Madrid 28007, Spain. [Galeano-Valle, Francisco; Demelo-Rodriguez, Pablo; Alvarez-Sala-Walther, Luis A.] Univ Complutense Madrid, Sch Med, Dept Med, Madrid 28007, Spain. [Katsiki, Niki] Ahepa Univ Hosp, Med Sch, Dept Internal Med 1, Div Endocrinol & Metab,Diabet Ctr, Thessaloniki 54621, Greece. C3 General University Gregorio Maranon Hospital; Universidad de Cordoba; CIBER - Centro de Investigacion Biomedica en Red; CIBEROBN; Instituto de Salud Carlos III; Complutense University of Madrid; Aristotle University of Thessaloniki; Ahepa University Hospital RP Alvarez-Sala-Walther, LA (通讯作者)，Hosp Gen Univ Gregorio Maranon, Internal Med, Madrid 28007, Spain.; Delgado-Lista, J (通讯作者)，Univ Cordoba, Reina Sofia Univ Hosp, Maimonides Biomed Res Inst Cordoba IMIBIC, Lipids & Atherosclerosis Unit,Dept Internal Med, Av Menendez Pidal S-N, Cordoba 14004, Spain.; Delgado-Lista, J (通讯作者)，ISCIII, CIBER Fisiopatol Obesidad & Nutr CIBEROBN, Madrid 28007, Spain.; Alvarez-Sala-Walther, LA (通讯作者)，Inst Invest Sanitaria Gregorio Maranon, Madrid 28007, Spain.; Alvarez-Sala-Walther, LA (通讯作者)，Univ Complutense Madrid, Sch Med, Dept Med, Madrid 28007, Spain. EM ditanopaola@gmail.com; azarel_00@hotmail.com; paco.galeano.valle@gmail.com; md1delij@uco.es; pbdemelo@hotmail.com; md1lomij@uco.es; nikikatsiki@hotmail.com; delgadolista@gmail.com; lalvarezsalaw@gmail.com RI Delgado-Lista, Javier/KAM-7412-2024; KATSIKI, NIKI/ADE-7999-2022; Demelo-Rodríguez, Pablo/AAV-5440-2021; Lopez-Miranda, Jose/Y-8306-2019; Torres Peña, José D/ABH-3312-2020 OI Galeano-Valle, Francisco/0000-0003-1321-6866; KATSIKI, NIKI/0000-0003-0894-2644; Demelo-Rodríguez, Pablo/0000-0002-3096-4711; Lopez-Miranda, Jose/0000-0002-8844-0718; Torres Peña, José D/0000-0003-1366-5549 CR Abenavoli L, 2018, PANMINERVA MED, V60, P41, DOI 10.23736/S0031-0808.18.03418-3 Abete I, 2011, NUTR METAB CARDIOVAS, V21, pB1, DOI 10.1016/j.numecd.2011.05.001 Ahn J, 2008, J HEPATOL, V49, P1019, DOI 10.1016/j.jhep.2008.08.012 Aird WC, 2007, CIRC RES, V100, P158, DOI 10.1161/01.RES.0000255691.76142.4a Albers AR, 2004, ARTERIOSCL THROM VAS, V24, pE179, DOI 10.1161/01.ATV.0000143479.97844.af Anania C, 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Brodosi, Lucia Barbanti, Francesca A. di Domizio, Silvia Petta, Salvo Marchesini, Giulio TI Lifestyle Changes for the Treatment of Nonalcoholic Fatty Liver Disease - A 2015-19 Update SO CURRENT PHARMACEUTICAL DESIGN LA English DT Review DE Behavior therapy; cirrhosis; fibrosis; food intake; information technology; physical activity steatosis ID PHYSICAL-ACTIVITY; WEIGHT-LOSS; MEDITERRANEAN DIET; REDUCES FEATURES; STEATOHEPATITIS; INTERVENTIONS; MANAGEMENT; NAFLD; METAANALYSIS; VALIDATION AB Background: Lifestyle interventions aimed at weight loss have been associated with unproved liver enzymes, reduced intrahepatic triglyceride content, and improved histology {including reduced fibrosis stage). Objective: To revise the evidence on the beneficial effects of lifestyle changes accumulated since 2015, following the publication of the pivotal Cuban experience with histologic outcome. Methods: A PubMed search covering the period 2015 to 'July 2019 was carried out All retrieved references were analyzed and double-checked by authors. Results: 20 new studies were identified; in addition, two relevant studies provided new evidence. Thirteen studies were classified as randomized, controlled studies, three as proof-of-concept/pilot studies, four as cohort observational studies. In an attempt to maintain a closer contact between participants and the treatment center, a study ed regular phone calls, another an e-mail service, a third was based on text messages, and finally, a study was totally Web-based. Notably, the web-based treatment, accessed following intense motivational interviewing, was not less effective than a standard group-based behavior program. Conclusion: Lifestyle changes should form the basis of any NAFLD intervention. Information technology provides the opportunity to expand treatment, bypassing job and time constraints in younger patients, and to maintain long-term contact between patients and therapists in the NAFLD population. C1 [Petroni, Maria L.; Brodosi, Lucia; Barbanti, Francesca A.; di Domizio, Silvia; Marchesini, Giulio] Alma Mater Univ, Dept Med & Surg Sci, Bologna, Italy. [Petta, Salvo] Univ Palermo, Gastroenterol Sect, DiBiMIS, Palermo, Italy. C3 University of Bologna; University of Palermo RP Marchesini, G (通讯作者)，Alma Mater Univ, Dept Med & Surg Sci, St Orsola Malpighi Hosp, Via Massarenti 9, I-40138 Bologna, Italy. EM giulio.marchesini@unibo.it RI ; PETRONI, MARIA LETIZIA/AAD-9430-2021; BRODOSI, LUCIA/ABF-6692-2020 OI Di Domizio, Silvia/0000-0001-8960-3120; PETRONI, MARIA LETIZIA/0000-0002-7040-6466; BRODOSI, LUCIA/0000-0002-7735-7847; Marchesini, Giulio/0000-0003-2407-9860; Barbanti, Francesca Alessana/0000-0002-8830-4177 FU Department of Medical and Surgical Sciences, "Alma Mater" University, Bologna, Italy FX LB was supported by a research contract from the Department of Medical and Surgical Sciences, "Alma Mater" University, Bologna, Italy. 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Pharm. Design PY 2020 VL 26 IS 10 BP 1110 EP 1118 DI 10.2174/131612826666200204095401 PG 9 WC Pharmacology & Pharmacy WE Science Citation Index Expanded (SCI-EXPANDED) SC Pharmacology & Pharmacy GA LK7ZQ UT WOS:000531080500012 PM 32013841 DA 2026-02-02 ER EF FN Clarivate Analytics Web of Science VR 1.0 PT J AU Mascarenhas, MR AF Mascarenhas, Maria R. TI Pediatric Anti-Inflammatory Diet SO PEDIATRIC ANNALS LA English DT Article ID MEDITERRANEAN DIET; ADHERENCE; ASSOCIATION; CHILDREN; ASTHMA; RISK; ADOLESCENTS; CALCIUM; PATTERN; STYLE AB The anti-inflammatory diet is based on two diets that have been shown to have many positive health effects-the Mediterranean diet and the Okinawan diet. The anti-inflammatory diet is more than just a prescription for healthy food, but rather a way of life characterized by a plant-based diet and a pattern of living that includes eating a diverse range of locally grown foods eaten in season, conviviality, culinary activities, physical activity, and rest. The Mediterranean diet has been shown to reduce the burden and even prevent the development of cardiovascular disease, breast cancer, depression, colorectal cancer, diabetes, obesity, asthma, and cognitive decline in adults. In children, there is emerging evidence demonstrating beneficial effects with regard to obesity, cardiorespiratory fitness, diabetes, fatty liver, academic performance, attention-deficit/hyperactivity disorder, asthma, and allergies. Maternal ingestion of the diet during pregnancy has also been shown to have positive effects on infants and children. C1 [Mascarenhas, Maria R.] Childrens Hosp Philadelphia, Div Gastroenterol Hepatol & Nutr, 324 South 34th St, Philadelphia, PA 19104 USA. [Mascarenhas, Maria R.] Childrens Hosp Philadelphia, Integrat Hlth Program, Philadelphia, PA 19104 USA. [Mascarenhas, Maria R.] Childrens Hosp Philadelphia, Dept Clin Nutr, Philadelphia, PA 19104 USA. [Mascarenhas, Maria R.] Univ Penn, Pediat, Perelman Sch Med, Philadelphia, PA 19104 USA. C3 University of Pennsylvania; Pennsylvania Medicine; Childrens Hospital of Philadelphia; University of Pennsylvania; Pennsylvania Medicine; Childrens Hospital of Philadelphia; University of Pennsylvania; Pennsylvania Medicine; Childrens Hospital of Philadelphia; University of Pennsylvania RP Mascarenhas, MR (通讯作者)，Childrens Hosp Philadelphia, Div Gastroenterol Hepatol & Nutr, 324 South 34th St, Philadelphia, PA 19104 USA. 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Ravandi, Amir Lehoczki, Andrea TI Dietary flaxseed: Cardiometabolic benefits and its role in promoting healthy aging SO GEROSCIENCE LA English DT Review DE Flaxseed; Cardiometabolic; Type 2 diabetes; Hypertension; Metabolic syndrome; Chronic kidney disease; Cardiovascular disease; Mortality ID ALPHA-LINOLENIC-ACID; CORONARY-HEART-DISEASE; C-REACTIVE PROTEIN; OXIDATIVE STRESS; CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; BLOOD-PRESSURE; MEDITERRANEAN DIET; RISK-FACTORS; SECOISOLARICIRESINOL DIGLUCOSIDE AB Flaxseed, a rich source of omega-3 polyunsaturated fatty acid alpha-linolenic acid (ALA), lignans, and soluble fiber, has attracted attention for its potential to improve multiple cardiometabolic risk factors. While its benefits are well-recognized, comprehensive evaluations of its direct impact on clinical outcomes, such as the prevention or progression of cardiometabolic diseases, remain limited. Additionally, its potential to support healthy aging and longevity through fundamental biological mechanisms has not been fully elucidated. This review synthesizes existing research on flaxseed supplementation, highlighting its effects on cardiometabolic risk factors and outcomes, the underlying biological mechanisms, and its broader implications for health promotion and aging. Findings demonstrate that flaxseed supplementation significantly improves several cardiometabolic risk factors, including body weight, body mass index, lipid levels, blood pressure, glycemic measures, markers of inflammation (e.g., C-reactive protein and interleukin-6), oxidative stress, and liver enzymes. Blood pressure reductions range from approximately 2 to 15 mmHg for systolic blood pressure and 1 to 7 mmHg for diastolic blood pressure, with the magnitude influenced by dose, duration, and baseline risk profiles. While direct evidence linking flaxseed to the prevention of hypertension, metabolic syndrome, metabolic dysfunction-associated steatotic liver disease, type 2 diabetes, chronic kidney disease, and cardiovascular disease is limited, its bioactive components-ALA, lignans, and fiber-are strongly associated with reduced risks of these conditions. The benefits of flaxseed are mediated through multiple pathways, including anti-inflammatory and antioxidant effects, improved lipid levels, improved glucose metabolism and insulin sensitivity, modulation of gut microbiota, and enhanced vascular health. Beyond cardiometabolic outcomes, flaxseed may influence key biological processes relevant to aging, underscoring its potential to promote healthy aging and longevity. Optimal cardiometabolic benefits appear to be achieved with ground whole flaxseed at doses of >= 30 g/day for at least 12 weeks, particularly among individuals at high cardiometabolic risk. Future research should focus on elucidating flaxseed's mechanisms of action, clarifying its role in disease prevention, and refining dietary recommendations to harness its potential for cardiometabolic health and aging interventions. C1 [Kunutsor, Setor K.; Jassal, Davinder S.; Ravandi, Amir] Univ Manitoba, St Boniface Hosp, Max Rady Coll Med, Rady Fac Hlth Sci,Dept Internal Med,Sect Cardiol, 409 Tache Ave, Winnipeg, MB R2H 2A6, Canada. [Ravandi, Amir] Univ Manitoba, Inst Cardiovasc Sci, Max Rady Coll Med, Rady Fac Hlth Sci,Dept Physiol & Pathophysiol, Winnipeg, MB, Canada. [Lehoczki, Andrea] Semmelweis Univ, Inst Prevent Med & Publ Hlth, Budapest, Hungary. [Lehoczki, Andrea] Semmelweis Univ, Doctoral Coll, Hlth Sci Program, Budapest, Hungary. C3 University of Manitoba; Saint Boniface Hospital; Children's Hospital Research Institute of Manitoba; University of Manitoba; Semmelweis University; Semmelweis University RP Kunutsor, SK (通讯作者)，Univ Manitoba, St Boniface Hosp, Max Rady Coll Med, Rady Fac Hlth Sci,Dept Internal Med,Sect Cardiol, 409 Tache Ave, Winnipeg, MB R2H 2A6, Canada. EM skk31@cantab.net RI KUNUTSOR, SETOR/H-9807-2019; Lehoczki, Andrea/LQK-7571-2024 OI KUNUTSOR, SETOR/0000-0002-2625-0273; FU Ministry of Innovation and Technology of Hungary from the National Research, Development and Innovation Fund [TKP2021-NKTA-47, RRF-2.3.1-21-2022-00003]; European University for Well-Being (EUniWell) program [101004093/EUniWell/EAC-A02-2019/EAC-A02-2019-1]; New National Excellence Program of the Ministry for Culture and Innovation from the source of the National Research, Development and Innovation Fund [EKOEP-2024-9] FX AL was supported by TKP2021-NKTA-47, implemented with the support provided by the Ministry of Innovation and Technology of Hungary from the National Research, Development and Innovation Fund, financed under the TKP2021-NKTA funding scheme; by funding through the National Cardiovascular Laboratory Program (RRF-2.3.1-21-2022-00003) provided by the Ministry of Innovation and Technology of Hungary from the National Research, Development and Innovation Fund; the European University for Well-Being (EUniWell) program (grant agreement number: 101004093/EUniWell/EAC-A02-2019/EAC-A02-2019-1) and by the EKOEP-2024-9 New National Excellence Program of the Ministry for Culture and Innovation from the source of the National Research, Development and Innovation Fund. The funding sources had no role in the study design; in the collection, analysis and interpretation of data; in the writing of the report; and in the decision to submit the article for publication. The content is solely the responsibility of the authors and does not necessarily represent the official views of the funding agencies. The 4o version of ChatGPT, developed by OpenAI, was used as a language tool to refine our writing and enhance the clarity of our work. 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Frye, Brett M. Negrey, Jacob D. Johnson, Corbin S. C. Sutphen, Courtney L. Molina, Anthony J. A. Yadav, Hariom Snyder-Mackler, Noah Register, Thomas C. TI The interactive effects of psychosocial stress and diet composition on health in primates SO NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS LA English DT Article DE Psychosocial stress; Mediterranean and Western diet; Nonhuman primates; Microbiome; Mitochondria; Neuroinflammation; Brain structure; Transcriptome; Ovarian function; Social isolation; Anxiety; Aging ID TYPE-2 DIABETES-MELLITUS; WESTERN-STYLE DIET; PSYCHOLOGICAL STRESS; MEDITERRANEAN DIET; SOCIAL-STATUS; MITOCHONDRIAL DYSFUNCTION; BRAIN STRUCTURE; GUT-BRAIN; CARDIOVASCULAR REACTIVITY; PREMENOPAUSAL MONKEYS AB Social disadvantage and diet composition independently impact myriad dimensions of health. They are closely entwined, as social disadvantage often yields poor diet quality, and may interact to fuel differential health outcomes. This paper reviews effects of psychosocial stress and diet composition on health in nonhuman primates and their implications for aging and human health. We examined the effects of social subordination stress and Mediterranean versus Western diet on multiple systems. We report that psychosocial stress and Western diet have independent and additive adverse effects on hypothalamic-pituitary-adrenal and autonomic nervous system reactivity to psychological stressors, brain structure, and ovarian function. Compared to the Mediterranean diet, the Western diet resulted in accelerated aging, nonalcoholic fatty liver disease, insulin resistance, gut microbial changes associated with increased disease risk, neuroinflammation, neuroanatomical perturbations, anxiety, and social isolation. This comprehensive, multisystem investigation lays the foundation for future investigations of the mechanistic underpinnings of psychosocial stress and diet effects on health, and advances the promise of the Mediterranean diet as a therapeutic intervention on psychosocial stress. C1 [Shively, Carol A.; Frye, Brett M.; Negrey, Jacob D.; Sutphen, Courtney L.; Register, Thomas C.] Wake Forest Univ, Bowman Gray Sch Med, Dept Pathol, Comparat Med, Winston Salem, NC USA. [Frye, Brett M.] Emory & Henry Coll, Dept Biol, Emory, VA USA. [Johnson, Corbin S. C.] Univ Washington, Dept Psychol, Seattle, WA USA. [Molina, Anthony J. A.] Univ Calif San Diego, Dept Med, San Diego, CA USA. [Yadav, Hariom] Univ S Florida, Microbiomes Inst, Ctr Microbiome Res, Tampa, FL USA. [Snyder-Mackler, Noah] Arizona State Univ, Ctr Evolut & Med, Tempe, AZ USA. [Snyder-Mackler, Noah] Arizona State Univ, Sch Life Sci, Tempe, AZ USA. [Snyder-Mackler, Noah] Arizona State Univ, Sch Human Evolut & Social Change, Tempe, AZ USA. [Shively, Carol A.] Wake Forest Univ, Bowman Gray Sch Med, Dept Pathol, Comparat Med, Med Ctr Blvd, Winston Salem, NC 27157 USA. C3 Wake Forest University; Wake Forest Baptist Medical Center; University of Washington; University of Washington Seattle; University of California System; University of California San Diego; State University System of Florida; University of South Florida; Arizona State University; Arizona State University-Tempe; Arizona State University; Arizona State University-Tempe; Arizona State University; Arizona State University-Tempe; Wake Forest University; Wake Forest Baptist Medical Center RP Shively, CA (通讯作者)，Wake Forest Univ, Bowman Gray Sch Med, Dept Pathol, Comparat Med, Med Ctr Blvd, Winston Salem, NC 27157 USA. EM cshively@wakehealth.edu RI ; Yadav, Hariom/I-2455-2018; Shively, Carol/L-2921-2019; Register, Thomas/KLY-9188-2024; Snyder-Mackler, Noah/N-7395-2013 OI Johnson, Corbin/0000-0001-9616-5755; Negrey, Jacob/0000-0001-7355-0319; FU National Institutes of Health [R01HL122393, R01HL087103]; [RF1AG058829]; National Institute on Aging [T32AG052354] Funding Source: NIH RePORTER FX This work was supported by the National Institutes of Health RF1AG058829, R01HL122393, and R01HL087103. 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Biobehav. Rev. PD SEP PY 2023 VL 152 AR 105320 DI 10.1016/j.neubiorev.2023.105320 EA JUL 2023 PG 13 WC Behavioral Sciences; Neurosciences WE Science Citation Index Expanded (SCI-EXPANDED) SC Behavioral Sciences; Neurosciences & Neurology GA Q5XF1 UT WOS:001058243500001 PM 37453725 OA Green Submitted DA 2026-02-02 ER PT J AU Ratziu, V AF Ratziu, Vlad TI Non-pharmacological interventions in non-alcoholic fatty liver disease patients SO LIVER INTERNATIONAL LA English DT Article; Proceedings Paper CT 10th Paris Hepatitis Conference / International Conference on the Management of Patients with Viral Hepatitis CY JAN 30-31, 2017 CL Paris, FRANCE DE diet; exercise; fibrosis; non-alcoholic steatohepatitis; steatosis ID LIFE-STYLE INTERVENTION; PHYSICAL-ACTIVITY; MEDITERRANEAN DIET; WEIGHT-LOSS; CARDIOVASCULAR-DISEASE; INSULIN-RESISTANCE; HEPATIC STEATOSIS; CARDIORESPIRATORY FITNESS; FRUCTOSE CONSUMPTION; LOW-CARBOHYDRATE AB Patients with non-alcoholic fatty liver disease have unhealthy diets, sedentary behaviour and not enough physical activity. This lifestyle triggers liver disease and probably favours its progression. It also has significant deleterious effects on health and longevity and should therefore be corrected by first-line therapy at all stages of the disease. However, important questions remain: is weight loss alone beneficial or do particular diets have beneficial effects beyond weight loss? Which specific micro- or macronutrients are clearly harmful? Does exercise without weight loss improve hepatic histology and what type of exercise is optimal? Does moderate or only vigorous exercise have metabolic and hepatic benefits? What is the efficacy of lifestyle measures outside of clinical trials? And most importantly, what is the turning point in the natural history of liver disease when non-pharmacological measures should be combined with drug therapy? C1 [Ratziu, Vlad] Univ Paris 06, Hop Pitie Salpetriere, Inst Cardiometab & Nutr, Paris, France. C3 Assistance Publique Hopitaux Paris (APHP); Hopital Universitaire Pitie-Salpetriere - APHP; Sorbonne Universite RP Ratziu, V (通讯作者)，Univ Paris 06, Hop Pitie Salpetriere, Inst Cardiometab & Nutr, Paris, France. 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S, 2007, J HEPATOL, V47, P711, DOI 10.1016/j.jhep.2007.06.020 NR 80 TC 38 Z9 40 U1 0 U2 2 PU WILEY PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1478-3223 EI 1478-3231 J9 LIVER INT JI Liver Int. PD JAN PY 2017 VL 37 SU 1 SI SI BP 90 EP 96 DI 10.1111/liv.13311 PG 7 WC Gastroenterology & Hepatology WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S) SC Gastroenterology & Hepatology GA FR0AX UT WOS:000418724400015 PM 28052636 OA Green Submitted, Bronze DA 2026-02-02 ER PT J AU Macków, M Dziubyna, T Jamer, T Slivinskyi, D Pytrus, T Neubauer, K Zwolinska-Wcislo, M Stawarski, A Piotrowska, E Nowacki, D AF Mackow, Monika Dziubyna, Tomasz Jamer, Tatiana Slivinskyi, Dmytro Pytrus, Tomasz Neubauer, Katarzyna Zwolinska-Wcislo, Malgorzata Stawarski, Andrzej Piotrowska, Ewa Nowacki, Dorian TI The Role of Dietary Ingredients and Herbs in the Prevention of Non-Communicable Chronic Liver Disease SO NUTRIENTS LA English DT Review DE diet; liver disease; fiber; probiotics; polyphenols; omega-3 fatty acids; herbs ID GREEN TEA POLYPHENOL; FATTY LIVER; HEPATOCELLULAR-CARCINOMA; PHYSICAL-ACTIVITY; MEDITERRANEAN DIET; INSULIN-RESISTANCE; HEPATIC STEATOSIS; LIPID-METABOLISM; FIBER INTAKE; RISK AB Background: Liver diseases are among the most commonly diagnosed conditions, with the main risk factors being inappropriate lifestyles, including poor diet, excessive alcohol consumption, low physical activity and smoking, including electronic cigarettes. Non-communicable chronic liver diseases also often develop as a result of accompanying overweight and obesity, as well as type 2 diabetes. Methods: The literature on risk factors for non-communicable chronic liver diseases, which show a high strong influence on their occurrence, was analysed. Results: Measures to prevent non-communicable chronic liver disease include the selection of suitable food ingredients that have proven protective effects on the liver. Such ingredients include dietary fibre, probiotics, herbs, various types of polyphenols and fatty acids (omega-3). Conclusions: Because of their liver-protective effects, nutritionists recommend consuming vegetables, fruits, herbs and spices that provide valuable ingredients with anti-inflammatory and anti-cancer effects. These components should be provided with food and, in the case of probiotics, supplementation appears to be important. As a preventive measure, a diet rich in these nutrients is therefore recommended, as well as one that prevents overweight and other diseases that can result in liver disease. C1 [Mackow, Monika; Piotrowska, Ewa; Nowacki, Dorian] Wroclaw Univ Environm & Life Sci, Fac Biotechnol & Food Sci, Dept Human Nutr, Chelmonskiego 37, PL-51630 Wroclaw, Poland. [Mackow, Monika] Reg Specialist Hosp Wroclaw, Res & Dev Ctr, Kamienskiego 73A, PL-51124 Wroclaw, Poland. [Dziubyna, Tomasz; Zwolinska-Wcislo, Malgorzata] Jagiellonian Univ, Fac Med, Dept Gastroenterol & Hepatol, Unit Clin Dietet,Med Coll, M Jakubowskiego 2, PL-30688 Krakow, Poland. [Jamer, Tatiana; Pytrus, Tomasz; Stawarski, Andrzej] Wroclaw Med Univ, Dept & Clin Paediat Gastroenterol & Nutr 2, M Curie Sklodowskiej 50-52, PL-50367 Wroclaw, Poland. [Slivinskyi, Dmytro] Wroclaw Univ Environm & Life Sci, Fac Biotechnol & Food Sci, Dept Fruit Vegetable & Plant Nutraceut Technol, Chelmonskiego 37, PL-51630 Wroclaw, Poland. [Neubauer, Katarzyna] Wroclaw Med Univ, Dept Clin Gastroenterol & Hepatol, Borowska 213, PL-50556 Wroclaw, Poland. [Zwolinska-Wcislo, Malgorzata] Jagiellonian Univ, Fac Med, Dept Gastroenterol & Hepatol, Med Coll, M Jakubowskiego 2, PL-30688 Krakow, Poland. C3 Wroclaw University of Environmental & Life Sciences; Jagiellonian University; Collegium Medicum Jagiellonian University; Wroclaw Medical University; Wroclaw University of Environmental & Life Sciences; Wroclaw Medical University; Jagiellonian University; Collegium Medicum Jagiellonian University RP Dziubyna, T (通讯作者)，Jagiellonian Univ, Fac Med, Dept Gastroenterol & Hepatol, Unit Clin Dietet,Med Coll, M Jakubowskiego 2, PL-30688 Krakow, Poland. EM monika.mackow@upwr.edu.pl; tomasz.dziubyna@uj.edu.pl; tatiana.jamer@umw.edu.pl; dmytro.slivinskyi@upwr.edu.pl; tomasz.pytrus@umw.edu.pl; katarzyna.neubauer@umw.edu.pl; m.zwolinska-wcislo@uj.edu.pl; andrzej.stawarski@umw.edu.pl; ewa.piotrowska@upwr.edu.pl; dorian.nowacki@upwr.edu.pl RI Maćków, Monika/X-4759-2018 OI Maćków, Monika/0000-0003-3961-7609; Slivinskyi, Dmytro/0009-0001-3433-1217; Dziubyna, Tomasz/0009-0002-9095-1207 FU Wroclstrok;aw University of Environmental; Jagiellonian University Medical College FX This research received no external funding. The APC is co-financed by the Wroc & lstrok;aw University of Environmental and Life Sciences, Medical University of Wroc & lstrok;aw and Jagiellonian University Medical College. 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Sood, Surbhi Broughton, Anna Cogan, Georgia Hickey, Megan Chan, Wai San Sudan, Sonal Nicoll, Amanda J. TI The Association between Diet and Hepatocellular Carcinoma: A Systematic Review SO NUTRIENTS LA English DT Review DE hepatocellular carcinoma; primary liver cancer; liver cancer; diet; dietary patterns; nutrition ID CHRONIC LIVER-DISEASE; MEDITERRANEAN DIET; CANCER-RISK; VEGETABLE CONSUMPTION; SUBSEQUENT RISK; GLYCEMIC INDEX; FATTY-ACIDS; METAANALYSIS; FRUIT; NUTRITION AB Globally, liver cancer is the sixth most common cause of cancer mortality, with hepatocellular carcinoma (HCC) being the most common type of primary liver cancer. Emerging evidence states that diet is recognised as a potential lifestyle-related risk factor for the development of HCC. The aim of this systematic review is to determine whether there is an association between diet and the development of HCC. Using the PRISMA guidelines, three databases (MEDLINE Complete, CINAHL and Embase) were systematically searched, and studies published until July 2020 were included. Thirty observational studies were selected. The protocol was registered with PROSPERO (CRD42019135240). Higher adherence to the Mediterranean dietary pattern, Alternative Healthy Eating Index-2010, the Urban Prudent Dietary Pattern, the Traditional Cantonese Dietary Pattern, intake of vegetables, wholegrains, fish, poultry, coffee, macronutrients such as monounsaturated fats and micronutrients such as vitamin E, vitamin B9, beta-carotene, manganese and potassium were associated with a reduced risk of HCC. The results suggest a potential role of diet in the development of HCC. Further quantitative research needs to be undertaken within a range of populations to investigate diet and the relationship with HCC risk. 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We investigated short-term effects of feeding rats five different dietary fats (palm oil (PO), olive oil (OA), safflower oil (LA), fish oil (170) and arachidonic acid (AA)) on tissue levels of 2-arachidonoylglycerol, anandamide, oleoylethanolamide, palmitoylethanolamide, stearoylethanolamide, linoleoylethanolamide, eicosapentaenoylethanolamide, docosahexaenoylethanolamide and tissue fatty acid composition. The LA-diet increased linoleoylethanolamide and linoleic acid in brain, jejunum and liver. The OA-diet increased brain levels of anandamide and oleoylethanolamide (not 2-arachidonoylglycerol) without changing tissue fatty acid composition. The same diet increased oleoylethanolamide in liver. All five dietary fats decreased oleoylethanolamide in jejunum without changing levels of anandamide, suggesting that dietary fat may have an orexigenic effect. The AA-diet increased anandamide and 2-arachidonoylglycerol in jejunum without effect on liver. The FO-diet decreased liver levels of all N-acylethanolamines (except eicosapentaenoylethanolamide and docosahexaenoylethanolamide) with similar changes in precursor lipids. The AA-diet and FO-diet had no effect on N-acylethanolamines, endocannabinoids or precursor lipids in brain. All N-acylethanolamines activated PPAR-alpha. In conclusion, short-term feeding of diets resembling human diets (Mediterranean diet high in monounsaturated fat, diet high in saturated fat, or diet high in polyunsaturated fat) can affect tissue levels of endocannabinoids and N-acylethanolamines. (C) 2008 Elsevier B.V. All rights reserved. C1 [Artmann, Andreas; Petersen, Gitte; Hansen, Harald S.] Univ Copenhagen, Dept Pharmacol & Pharmacotherapy, Fac Pharmaceut Sci, DK-2100 Copenhagen, Denmark. [Skonberg, Christian; Hansen, Steen Honore] Univ Copenhagen, Fac Pharmaceut Sci, Dept Pharmaceut & Analyt Chem, DK-2100 Copenhagen, Denmark. [Hellgren, Lars I.] Tech Univ Denmark, BioCtr DTU, DK-2800 Lyngby, Denmark. 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Biophys. Acta Mol. Cell Biol. Lipids PD APR PY 2008 VL 1781 IS 4 BP 200 EP 212 DI 10.1016/j.bbalip.2008.01.006 PG 13 WC Biochemistry & Molecular Biology; Biophysics; Cell Biology WE Science Citation Index Expanded (SCI-EXPANDED) SC Biochemistry & Molecular Biology; Biophysics; Cell Biology GA 294DU UT WOS:000255385300004 PM 18316044 DA 2026-02-02 ER PT J AU Muscogiuri, G Barrea, L Laudisio, D Di Somma, C Pugliese, G Salzano, C Colao, A Savastano, S AF Muscogiuri, Giovanna Barrea, Luigi Laudisio, Daniela Di Somma, Carolina Pugliese, Gabriella Salzano, Ciro Colao, Annamaria Savastano, Silvia TI Somatotropic Axis and Obesity: Is There Any Role for the Mediterranean Diet? SO NUTRIENTS LA English DT Article DE obesity; GH deficiency; IGF-1; insulin resistance; Mediterranean diet ID BIOELECTRICAL-IMPEDANCE ANALYSIS; FATTY LIVER-DISEASE; GROWTH-HORMONE DEFICIENCY; METABOLIC SYNDROME; PHASE-ANGLE; NONALCOHOLIC STEATOHEPATITIS; BIOIMPEDANCE ANALYSIS; CARDIOVASCULAR RISK; GLUCOSE-TOLERANCE; CLINICAL SEVERITY AB Obesity is associated with reduced spontaneous and stimulated growth hormone (GH) secretion and basal insulin-like growth factor I (IGF-1) levels-which in turn is associated with increased prevalence of cardiovascular risk factors. The aim of this study was to investigate: (1) the association of somatotropic axis with cardiometabolic status; (2) the association of somatotropic axis with the Mediterranean diet and nutritional pattern in people with obesity. Cross-sectional observational study was carried out in 200 adult women, aged 36.98 +/- 11.10 years with severe obesity (body mass index-BMI of 45.19 +/- 6.30 kg/m(2)). The adherence to the Mediterranean diet and the total calorie intake was assessed. Anthropometric measurements, body composition and biochemical profile were determined along with Growth Hormone (GH)/Insulin like Growth Factor 1 (IGF-1) axis and insulin resistance (homeostatic model assessment for insulin resistance-HoMA-IR). The enrolled subjects were compared after being divided according to GH peak response and according to IGF-1 standard deviation scores (SDS). Derangements of GH peak were detected in 61.5% of studied patients while IGF-1 deficiency was detected in 71% of the population. Both blunted GH peak response and IGF-1 SDS were indicators of derangements of somatotropic axis and were associated with comparable results in terms of cardiometabolic sequelae. Both GH peak and IGF-1 levels were inversely associated with anthropometric and metabolic parameters. The adherence to the Mediterranean diet predicts GH peak response. Fatty liver index (FLI), fat mass (FM) and phase angle (PhA) were predictive factors of GH peak response as well. In conclusion derangements of somatotropic axis is associated with a worse cardiometabolic profile in people with obesity. A high adherence to the Mediterranean diet-and in particular protein intake-was associated with a better GH status. C1 [Muscogiuri, Giovanna; Barrea, Luigi; Laudisio, Daniela; Pugliese, Gabriella; Salzano, Ciro; Colao, Annamaria; Savastano, Silvia] Univ Naples Federico II, Med Sch Naples, Unit Endocrinol, Dipartimento Med Clin & Chirurg, Via Sergio Pansini 5, I-80131 Naples, Italy. [Di Somma, Carolina] IRCCS SDN, Via Gianturco 113, I-80143 Naples, Italy. C3 University of Naples Federico II; IRCCS Istituto di Ricerca Diagnostica e Nucleare (SDN) RP Muscogiuri, G (通讯作者)，Univ Naples Federico II, Med Sch Naples, Unit Endocrinol, Dipartimento Med Clin & Chirurg, Via Sergio Pansini 5, I-80131 Naples, Italy. EM giovanna.muscogiuri@gmail.com; luigi.barrea@unina.it; dani.lauidisio@libero.it; cdisomma@unina.it; robiniapugliese@gmail.com; cirosalzano89@gmail.com; colao@unina.it; sisavast@unina.it RI Di Somma, Carolina/K-7772-2016; Savastano, Silvia/K-6546-2016; Barrea, Luigi/K-6551-2016; Muscogiuri, Giovanna/K-5817-2016; Colao, Annamaria/A-7671-2011 OI Di Somma, Carolina/0000-0002-5724-1951; Savastano, Silvia/0000-0002-3211-4307; Barrea, Luigi/0000-0001-9054-456X; Salzano, Ciro/0000-0001-7966-7868; CR Abdu TAM, 2001, CLIN ENDOCRINOL, V55, P209, DOI 10.1046/j.1365-2265.2001.01320.x Amato MC, 2010, DIABETES CARE, V33, P920, DOI 10.2337/dc09-1825 Martínez-González MA, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0043134 [Anonymous], 1996, Am J Clin Nutr, V64, p524S, DOI 10.1093/ajcn/64.3.524S Attallah H, 2006, GROWTH HORM IGF RES, V16, pS62, DOI 10.1016/j.ghir.2006.03.004 Attanasio AF, 2010, J CLIN ENDOCR METAB, V95, P74, DOI 10.1210/jc.2009-1326 Barbosa-Silva MCG, 2005, AM J CLIN NUTR, V82, P49, 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11 IS 9 AR 2228 DI 10.3390/nu11092228 PG 15 WC Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Nutrition & Dietetics GA JA6PP UT WOS:000487964600031 PM 31527400 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Sivell, C AF Sivell, Christopher TI Nonalcoholic Fatty Liver Disease: A Silent Epidemic SO GASTROENTEROLOGY NURSING LA English DT Article ID MEDITERRANEAN DIET; STEATOHEPATITIS; STEATOSIS; DIAGNOSIS; OBESE AB Nonalcoholic fatty liver disease is a growing condition among adolescent and adult populations, present in around 20%-30% of people in the United Kingdom. Nonalcoholic fatty liver disease is known as a silent disease and over many years may go on to cause nonalcoholic steatohepatitis. In the future it may become a leading contributor to cirrhosis, liver transplantation, and mortality. In recent years, programs have been set up to raise awareness of this condition with the first International NASH (nonalcoholic steatohepatitis) Day taking place in 2018; nevertheless, nonalcoholic fatty liver disease and nonalcoholic steatohepatitis is still not clearly understood by many. An extensive review has shown a lack of nursing literature on this topic, and effective specialist nurse input for this patient group should be a key component in tackling this growing epidemic in the years to come. C1 [Sivell, Christopher] Royal London Hosp, Grahame Hayton Unit, Barts Hlth NHS Trust, London, England. C3 Barts Health NHS Trust; Royal London Hospital RP Sivell, C (通讯作者)，Royal London Hosp, Grahame Hayton Unit, Barts Hlth NHS Trust, London E1 1FR, England. 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Nurs. PD SEP-OCT PY 2019 VL 42 IS 5 BP 428 EP 434 DI 10.1097/SGA.0000000000000443 PG 7 WC Gastroenterology & Hepatology; Nursing WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI) SC Gastroenterology & Hepatology; Nursing GA JU6XD UT WOS:000501816300005 PM 31574071 DA 2026-02-02 ER PT J AU de Sousa, IF Pedroso, AP de Andrade, IS Boldarine, VT Tashima, AK Oyama, LM Lionetti, L Ribeiro, EB AF de Sousa, Isy F. Pedroso, Amanda P. de Andrade, Iracema S. Boldarine, Valter T. Tashima, Alexandre K. Oyama, Lila M. Lionetti, Lilla Ribeiro, Eliane B. TI High-fat but not normal-fat intake of extra virgin olive oil modulates the liver proteome of mice SO EUROPEAN JOURNAL OF NUTRITION LA English DT Article DE Mediterranean diet; Fatty acids oxidation; Gluconeogenesis; Lipid synthesis; Body adiposity; Glycemia ID MEDITERRANEAN DIET; GLUCOSE-METABOLISM; BETA-OXIDATION; ENRICHED DIET; FOOD-INTAKE; ACID; RATS; INHIBITION; EXPRESSION; OLEOYLETHANOLAMIDE AB Purpose The metabolic benefits of the Mediterranean diet have been largely attributed to its olive oil content. Whether the ingested fat amount is relevant to these effects is not clear. We thus compared the effects of high-fat and normal-fat intake of extra-virgin olive oil (EVOO) on the liver proteome. Methods Three groups of mice were fed for 12 weeks with either normal-fat diets containing either soybean oil (control, C) or EVOO (NO) or a high-fat EVOO diet (HO). Body weight and food intake were measured weekly and serum parameters were analyzed. The liver was processed for data-independent acquisition mass spectrometry-based proteomics. The differentially expressed proteins among the groups were submitted to pathway enrichment analysis. Results The consumption of HO diet reduced food intake and serum triglycerides, while it preserved body weight gain, adiposity, and glycemia. However, it increased serum cholesterol and liver mass. The proteomic analysis showed 98 altered proteins, which were allocated in 27 significantly enriched pathways. The pathway analysis suggested stimulation of mitochondrial and peroxissomal beta-oxidation, and inhibition of lipid synthesis and gluconeogenesis in the HO group. Although the NO group failed to show significant liver proteome alterations, it presented reduced body fat, body weight gain, and serum triglycerides and glucose levels. Conclusion The data indicate that the intake of the HO diet induced hepatic adjustments, which were partially successful in counteracting the detrimental outcomes of a high-fat feeding. Contrastingly, the NO diet had beneficial effects which were not accompanied by significant modifications on hepatic proteome. C1 [de Sousa, Isy F.; Pedroso, Amanda P.; de Andrade, Iracema S.; Boldarine, Valter T.; Oyama, Lila M.; Ribeiro, Eliane B.] Univ Fed Sao Paulo, Escola Paulista Med, Dept Fisiol, Rua Botucatu 862, BR-04023062 Sao Paulo, SP, Brazil. [Tashima, Alexandre K.] Univ Fed Sao Paulo, Escola Paulista Med, Dept Bioquim, Sao Paulo, SP, Brazil. [de Sousa, Isy F.; Lionetti, Lilla] Univ Salerno, Dipartimento Chim & Biol Adolfo Zambelli, Salerno, Italy. C3 Universidade Federal de Sao Paulo (UNIFESP); Universidade Federal de Sao Paulo (UNIFESP); University of Salerno RP Ribeiro, EB (通讯作者)，Univ Fed Sao Paulo, Escola Paulista Med, Dept Fisiol, Rua Botucatu 862, BR-04023062 Sao Paulo, SP, Brazil. EM eliane.beraldi@gmail.com RI de Andrade, Iracema/P-5344-2018; Oyama, Lila/B-7609-2012; Boldarine, Valter/AAC-9086-2020; Peoso, Amanda Paula/A-2310-2017; Tashima, Alexane Keiji/B-8228-2015; Lionetti, Lillà/AAM-1756-2021 OI Peoso, Amanda Paula/0000-0001-7088-0187; Tashima, Alexane Keiji/0000-0002-1332-8895; Lionetti, Lillà/0000-0002-4059-8030 FU Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior-Brasil (Capes) [001]; Conselho Nacional de Pesquisa (CNPq) [309505/2017-8, 453924/2014-0]; Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [2012/03172-4] FX This study was financed by the Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior-Brasil (Capes)-Finance Code 001; Conselho Nacional de Pesquisa (CNPq)-Process number 309505/2017-8 e 453924/2014-0 and Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)-Process number 2012/03172-4. 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J. Nutr. PD APR PY 2021 VL 60 IS 3 BP 1375 EP 1388 DI 10.1007/s00394-020-02323-z EA JUL 2020 PG 14 WC Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Nutrition & Dietetics GA RB4OG UT WOS:000552886200001 PM 32712699 DA 2026-02-02 ER PT J AU Dubin, SM Vadivelu, J Copur-Dahi, N Miranda, L Palermo, D Pandey, B Groessl, EJ Ho, SB AF Dubin, Sterling M. Vadivelu, Jaya Copur-Dahi, Nedret Miranda, Leslie Palermo, Dana Pandey, Braj Groessl, Erik J. Ho, Samuel B. TI A Simple Dietary Questionnaire Correlates With Formal Dietitian Evaluation and Frequently Identifies Specific Clinical Interventions in an Outpatient Gastroenterology Clinic SO JOURNAL OF CLINICAL GASTROENTEROLOGY LA English DT Article DE diet; obesity; nonalcoholic fatty liver disease; metabolic syndrome; Mediterranean diet ID IRRITABLE-BOWEL-SYNDROME; MEDITERRANEAN DIET; WEIGHT-LOSS; UNITED-STATES; CANCER-RISK; DISEASE; OBESITY; MANAGEMENT; COMPONENTS; HEALTH AB Background: The spectrum of gastroenterology-related diseases related to obesity is growing. Few clinical tools exist to aid in clinician-guided dietary counseling. Goals: (1) Develop and validate a 1-page diet history form that would provide information on dietary factors that can contribute to gastrointestinal (GI) illness and to assess adherence to the Mediterranean diet; and (2) evaluate the form in a general GI clinic to determine its potential utility as a clinical tool. Study: A 1-page diet history form was developed and underwent qualitative and quantitative validation in comparison to a formal diet evaluation by a registered dietitian. The form was then evaluated in consecutive patients attending a general GI clinic, and analyzed for overall diet content, compliance with a Mediterranean diet, and presence of high-risk (red flag) dietary behaviors. Results: The form was evaluated in 134 patients. In a validation cohort (n=30) the qualitative dietary components measured were highly concordant with a formal dietary interview. Total daily calorie intake correlated with formal dietary review (R=0.61), but tended to underestimate total calories due to less precision in portion size. The prospective cohort (n=104) patients had a mean body mass index of 29.8. Overall, 52.9% were obese, 50% had metabolic syndrome, and 51% had a primary GI illness directly impacted by dietary factors (gastroesophageal reflux, irritable bowel, fatty liver). Overall, 85.6% of patients documented red flag behaviors. Patients with obesity trended for more red flags than overweight or normal body mass index groups. Conclusion: A 1-page diet questionnaire correlated well with formal dietary assessment and identified clinically relevant dietary interventions in a high percentage of GI patients. C1 [Dubin, Sterling M.; Vadivelu, Jaya; Copur-Dahi, Nedret; Miranda, Leslie; Palermo, Dana; Pandey, Braj; Groessl, Erik J.; Ho, Samuel B.] VA San Diego Healthcare Syst, Dept Med, 3350 La Jolla Village Dr, San Diego, CA 92161 USA. [Dubin, Sterling M.; Vadivelu, Jaya; Copur-Dahi, Nedret; Miranda, Leslie; Palermo, Dana; Pandey, Braj; Groessl, Erik J.; Ho, Samuel B.] VA San Diego Healthcare Syst, Dept Nutr, 3350 La Jolla Village Dr, San Diego, CA 92161 USA. [Dubin, Sterling M.; Vadivelu, Jaya; Copur-Dahi, Nedret; Miranda, Leslie; Palermo, Dana; Pandey, Braj; Groessl, Erik J.; Ho, Samuel B.] VA San Diego Healthcare Syst, Dept Hlth Serv Res & Dev, 3350 La Jolla Village Dr, San Diego, CA 92161 USA. [Dubin, Sterling M.; Copur-Dahi, Nedret; Pandey, Braj; Groessl, Erik J.; Ho, Samuel B.] Univ Calif San Diego, Dept Med, San Diego, CA 92103 USA. C3 US Department of Veterans Affairs; Veterans Health Administration (VHA); VA San Diego Healthcare System; US Department of Veterans Affairs; Veterans Health Administration (VHA); VA San Diego Healthcare System; US Department of Veterans Affairs; Veterans Health Administration (VHA); VA San Diego Healthcare System; University of California System; University of California San Diego RP Ho, SB (通讯作者)，VA San Diego Healthcare Syst, Dept Med, 3350 La Jolla Village Dr, San Diego, CA 92161 USA.; Ho, SB (通讯作者)，VA San Diego Healthcare Syst, Dept Nutr, 3350 La Jolla Village Dr, San Diego, CA 92161 USA.; Ho, SB (通讯作者)，VA San Diego Healthcare Syst, Dept Hlth Serv Res & Dev, 3350 La Jolla Village Dr, San Diego, CA 92161 USA. EM samuel.ho2@va.gov OI Ho, Samuel B/0000-0001-6730-6512 FU Research Service of the Department of Veterans Affairs; Veterans Affairs HSRD; Genetech, Inc.; Gilead Pharmaceuticals Inc.; Prime Education Inc.; Abbvie Pharmaceuticals Inc. FX Supported by the Research Service of the Department of Veterans Affairs and Veterans Affairs HSR&D. S.B.H.: research and grant support: Genetech, Inc.; Gilead Pharmaceuticals Inc.; speakers fees: Prime Education Inc., Abbvie Pharmaceuticals Inc.; consulting: Gilead Pharmaceuticals Inc.; Ventria Inc. The remaining authors declare that they have nothing to disclose. 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PHILADELPHIA, PA 19106 USA SN 1949-0976 EI 1949-0984 J9 GUT MICROBES JI Gut Microbes PD DEC 18 PY 2023 VL 15 IS 2 AR 2240031 DI 10.1080/19490976.2023.2240031 PG 15 WC Gastroenterology & Hepatology; Microbiology WE Science Citation Index Expanded (SCI-EXPANDED) SC Gastroenterology & Hepatology; Microbiology GA W7WD4 UT WOS:001093684000001 PM 37615334 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Polyzos, SA Kang, ES Boutari, C Rhee, EJ Mantzoros, CS AF Polyzos, Stergios A. Kang, Eun Seok Boutari, Chrysoula Rhee, Eun-Jung Mantzoros, Christos S. TI Current and emerging pharmacological options for the treatment of nonalcoholic steatohepatitis SO METABOLISM-CLINICAL AND EXPERIMENTAL LA English DT Article DE Farnesoid X receptor agonist; Fibrosis; Nonalcoholic fatty liver disease; Nonalcoholic steatohepatitis; Thiazolidinediones; Treatment ID FATTY LIVER-DISEASE; TYPE-2 DIABETES-MELLITUS; ACTIVATED RECEPTOR-ALPHA; CORONARY-HEART-DISEASE; INSULIN-RESISTANCE; VITAMIN-E; HEPATIC STEATOSIS; OBETICHOLIC ACID; BLADDER-CANCER; OPEN-LABEL AB Nonalcoholic fatty liver disease (NAFLD) is a highly prevalent disease and important unmet medical need. Current guidelines recommend, under specific restrictions, pioglitazone or vitamin E in patients with NASH and significant fibrosis, but the use of both remains off-label. We summarize evidence on medications for the treatment of nonalcoholic steatohepatitis (NASH), since NASH has been mainly associated with higher morbidity and mortality. Some of these medications are currently in phase 3 clinical trials, including obeticholic acid (a farnesoid X receptor agonist), elafibranor (a peroxisome proliferator activated receptor [PPAR]-alpha/delta dual agonist), cenicriviroc (a C-C chemokine receptor antagonist), MSDC-0602 K (a PPAR sparing modulator), selonsertib (an apoptosis signal-regulating kinase-1 inhibitor) and resmetirom (a thyroid hormone receptor agonist). A significant research effort is also targeting PPARs and selective PPAR modulators, including INT131 and pemafibrate, with the expectation that novel drugs may have beneficial effects similar to those of pioglitazone, but without the associated adverse effects. Whether these and other medications could offer tangible therapeutic benefits, alone or in combination, apparently on a background of lifestyle modification, i.e. exercise and a healthy dietary pattern (e.g. Mediterranean diet) remain to be proven. In conclusion, major advances are expected for the treatment of NASH. (c) 2020 Elsevier Inc. All rights reserved. C1 [Polyzos, Stergios A.] Aristotle Univ Thessaloniki, Sch Med, Lab Pharmacol 1, Thessaloniki, Macedonia, Greece. [Kang, Eun Seok] Yonsei Univ, Coll Med, Dept Internal Med, Severance Hosp Diabet Ctr,Div Endocrinol & Metab, Seoul, South Korea. [Boutari, Chrysoula] Aristotle Univ Thessaloniki, Ippokrat Hosp, Sch Med, Dept Internal Med,Propedeut 2, Thessaloniki, Macedonia, Greece. [Rhee, Eun-Jung] Sungkyunkwan Univ, Sch Med, Kangbuk Samsung Hosp, Div Endocrinol & Metab,Dept Internal Med, Seoul, South Korea. [Mantzoros, Christos S.] Harvard Med Sch, Beth Israel Deaconess Med Ctr, Dept Internal Med, Div Endocrinol Diabet & Metab, Boston, MA 02115 USA. [Mantzoros, Christos S.] Harvard Med Sch, Boston VA Healthcare Syst, Sect Endocrinol, Boston, MA 02115 USA. C3 Aristotle University of Thessaloniki; Yonsei University; Yonsei University Health System; Aristotle University of Thessaloniki; Sungkyunkwan University (SKKU); Samsung Medical Center; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Beth Israel Deaconess Medical Center; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; US Department of Veterans Affairs; Veterans Health Administration (VHA); VA Boston Healthcare System RP Kang, ES (通讯作者)，Yonsei Univ, Coll Med, Dept Internal Med, Severance Hosp Diabet Ctr,Div Endocrinol & Metab, Seoul, South Korea.; Mantzoros, CS (通讯作者)，Harvard Med Sch, Boston VA Healthcare Syst, Sect Endocrinol, Boston, MA 02115 USA. EM edgo@yuhs.ac; cmantzor@bidmc.harvard.edu RI Polyzos, Stergios/H-2844-2019; Boutari, Chrysoula/ABW-6757-2022; Rhee, Eun-Jung/M-9294-2015; Mantzoros, Christos/Y-2902-2019 OI Polyzos, Stergios/0000-0001-9232-4042; Kang, Eun Seok/0000-0002-0364-4675; Boutari, Chrysoula/0000-0002-0053-2440; FU National Research Foundation of Korea (NRF) - Korean government (MSIP) [NRF-2019R1A2C2007514] FX Dr Kang's contribution to thisworkwas supported by a National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIP) (No. NRF-2019R1A2C2007514) to ES Kang. 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Exp. PD OCT PY 2020 VL 111 SU S AR 154203 DI 10.1016/j.metabol.2020.154203 PG 16 WC Endocrinology & Metabolism WE Science Citation Index Expanded (SCI-EXPANDED) SC Endocrinology & Metabolism GA NZ1FB UT WOS:000576836200004 PM 32151660 DA 2026-02-02 ER PT J AU Di Renzo, L Cinelli, G Dri, M Gualtieri, P Attinà, A Leggeri, C Cenname, G Esposito, E Pujia, A Salimei, C De Lorenzo, A AF Di Renzo, Laura Cinelli, Giulia Dri, Maria Gualtieri, Paola Attina, Alda Leggeri, Claudia Cenname, Giuseppe Esposito, Ernesto Pujia, Alberto Salimei, Chiara De Lorenzo, Antonino TI Mediterranean Personalized Diet Combined with Physical Activity Therapy for the Prevention of Cardiovascular Diseases in Italian Women SO NUTRIENTS LA English DT Article DE cardiovascular disease; Mediterranean diet; non-communicable disease; obesity; physical activity ID LIPID-ACCUMULATION PRODUCT; FATTY LIVER INDEX; BODY-MASS INDEX; METABOLIC SYNDROME; ADIPOSOPATHY; CHOLESTEROL; VALIDATION; EQUATIONS; FIBROSIS; OBESITY AB Cardiovascular diseases (CVDs) and inflammatory risk indexes are used to calculate the exposure to morbidity. Most of them are suggested by the American College of Cardiology/American Heart Association to predict the risk of CVDs diagnosis in primary prevention, instead of treating the ongoing pathology. Prevention starts from habit changes with the prescription of diet and physical activity (PA). The aim of the study is to investigate the effectiveness of a personalized Mediterranean Diet (MD) and a PA intervention, on the risk indexes Atherogenic Index of Plasma (AIP), Lipid Accumulation Product (LAP) and Fatty Liver Index (FLI) in a population of women at risk of CVDs with different pathological conditions. After treatment, patients achieved the best results in body composition (BC) and laboratory tests. The BC analysis showed a significant reduction of total body Fat Mass (FM). CVDs risk indexes significantly decreased, except for Neutrophil/Lymphocyte (NLR) and Platelet/Lymphocyte Ratios (PLR). The reduction of the CVDs indexes associated with lipid profile was linked to both weight and FM decrease. AIP and LAP were significantly reduced when losing fat mass and body weight, respectively. A personalized MD therapy plus a PA program led to body weight loss, BC remodelling and risk indexes reduction. C1 [Di Renzo, Laura; Gualtieri, Paola; De Lorenzo, Antonino] Univ Roma Tor Vergata, Dept Biomed & Prevent, Sect Clin Nutr & Nutrigen, I-00133 Rome, Italy. [Di Renzo, Laura; Pujia, Alberto] Univ Roma Tor Vergata, Dept Biomed & Prevent, I-00133 Rome, Italy. [Cinelli, Giulia; Attina, Alda; Leggeri, Claudia] Univ Roma Tor Vergata, Sch Specializat Food Sci, I-00133 Rome, Italy. [Cinelli, Giulia] IRCCS, Predict & Prevent Med Res Unit, Bambino Gesu Childrens Hosp, I-00165 Rome, Italy. [Dri, Maria] Univ Roma Tor Vergata, Sch Appl Med Surg Sci, Dept Surg Sci, I-00133 Rome, Italy. [Cenname, Giuseppe] Comando Gen Arma Carabinieri, Direz Sanita, I-00197 Rome, Italy. [Esposito, Ernesto] Dept Human Policies Gen Directorate Basilicata Re, I-85100 Potenza, Italy. [Salimei, Chiara] Univ Roma Tor Vergata, Dept Syst Med, I-00133 Rome, Italy. C3 University of Rome Tor Vergata; University of Rome Tor Vergata; University of Rome Tor Vergata; IRCCS Bambino Gesu; University of Rome Tor Vergata; University of Rome Tor Vergata RP Di Renzo, L (通讯作者)，Univ Roma Tor Vergata, Dept Biomed & Prevent, Sect Clin Nutr & Nutrigen, I-00133 Rome, Italy.; Di Renzo, L (通讯作者)，Univ Roma Tor Vergata, Dept Biomed & Prevent, I-00133 Rome, Italy. EM laura.di.renzo@uniroma2.it; giuliacinelli88@gmail.com; marystenr@hotmail.it; paola.gualtieri@uniroma2.it; alda.attina@gmail.com; claudialeggeri@gmail.com; giuseppe.cenname@carabinieri.it; ernesto.esposit1962@gmail.com; albpujia@gmail.com; chiara.salimei@gmail.com; delorenzo@uniroma2.it RI Alda, Attinà/GON-7428-2022; di renzo, laura/ACB-2003-2022; Cinelli, Giulia/AAI-1255-2019; Pujia, Alberto/LTZ-8813-2024; Gualtieri, Paola/AAS-1684-2020; SALIMEI, CHIARA/OEO-8852-2025 OI di renzo, laura/0000-0001-8875-6723; Cinelli, Giulia/0000-0001-6985-3982; De Lorenzo, Antonino/0000-0001-6524-4493; Pujia, Alberto/0000-0001-5701-1251; Gualtieri, Paola/0000-0003-1533-4276; SALIMEI, CHIARA/0000-0002-1649-0417 CR Al-Osami MH, 2020, ADV RHEUMATOL, V60, DOI 10.1186/s42358-020-0113-5 Ambale-Venkatesh Bharath, 2017, Circ Res, V121, P1092, DOI 10.1161/CIRCRESAHA.117.311312 [Anonymous], 2003, WORLD HLTH REP Arnett DK, 2019, J AM COLL CARDIOL, V74, P1429, DOI 10.1016/j.jacc.2019.07.011 Arnett DK, 2019, 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Tzima, Natalia Pitsavos, Christos Panagiotakos, Demosthenes B. Chrysohoou, Christina Polychronopoulos, Evangelos Skoumas, John Stefanadis, Christodoulos TI Adherence to the Mediterranean diet moderates the association of aminotransferases with the prevalence of the metabolic syndrome; the ATTICA study SO NUTRITION & METABOLISM LA English DT Article ID FATTY LIVER-DISEASE; GAMMA-GLUTAMYL-TRANSFERASE; ALANINE AMINOTRANSFERASE; INSULIN SENSITIVITY; RISK; RESISTANCE; MARKERS; ADULTS; HYPERTENSION; INFLAMMATION AB Background: Elevated liver enzymes are markers of liver steatosis and metabolic syndrome. We aimed to investigate the association of Mediterranean diet on the relationship between aminotransferases (i.e., AST, ALT, gGT) and the metabolic syndrome. Methods: The ATTICA study has randomly enrolled 1514 adult males (18-87 yrs) and 1528 females (18-89 yrs) from the greater area of Athens. Adherence to Mediterranean diet was assessed through the MedDietScore. According to NCEP III criteria, participants were classified into those with or without the metabolic syndrome. Results: Women with metabolic syndrome had higher gamma GT (p = 0.02) and lower AST/ALT levels (p = 0.018) than those without, and men with metabolic had a lower AST/ALT ratio (p = 0.01) compared to those without metabolic syndrome. The AST/ALT ratio was also positively correlated with MedDietScore (rho = 0.17, p < 0.001), while higher MedDietScore was associated with lower likelihood of having the metabolic syndrome in a multi-adjusted analysis (OR = 0.34, 95% CI: 0.16-0.73). Stratified analysis by the level of adherence to the Mediterranean diet, revealed that only in subjects away or with moderate adherence to the Mediterranean diet, an increase in the AST/ALT ratio was associated with lower likelihood of having the metabolic syndrome (OR = 0.33, p < 0.05 and OR = 0.34, p < 0.09, respectively); however, when we focused in those with greater adherence to the Mediterranean diet, AST/ALT ratio was not associated with the presence of the syndrome (OR = 0.51, p = 0.55). These findings remained similar in both genders, and even when the quantity of alcohol drinking was taken into account. Conclusion: Aminotransferases ratio constitutes a marker of the metabolic syndrome among healthy adults; however, this relationship is moderated when individuals are close to the Mediterranean dietary pattern. C1 [Tzima, Natalia; Panagiotakos, Demosthenes B.; Polychronopoulos, Evangelos] Harokopio Univ, Dept Nutr Sci Dietet, Athens, Greece. [Pitsavos, Christos; Chrysohoou, Christina; Skoumas, John; Stefanadis, Christodoulos] Univ Athens, Sch Med, Cardiol Clin 1, GR-11527 Athens, Greece. C3 Harokopio University Athens; National & Kapodistrian University of Athens RP Tzima, N (通讯作者)，Harokopio Univ, Dept Nutr Sci Dietet, Athens, Greece. EM ntzima@parliament.gr; cpitsavo@med.uoa.gr; s.b.panagiotakos@usa.net; chrysohoou@usa.net; evpol@hua.gr; d.b.panagiotakos@usa.net; d.b.panagiotakos@usa.net RI ; Stefanadis, Christodoulos/ABH-2232-2020; Panagiotakos, Demosthenes/K-8294-2019 OI Polychronopoulos, Evangelos/0000-0001-7061-4081; Stefanadis, Christodoulos/0000-0001-5974-6454; Chrysohoou, Christina/0000-0002-6340-3996 FU Hellenic Cardiological Society [HCS2002]; Hellenic Atherosclerosis Society FX The ATTICA study was supported by research grants from the Hellenic Cardiological Society (HCS2002) and the Hellenic Atherosclerosis Society (2006). The authors would like to thank the filed investigators of "ATTICA" study: A. Zeimbekis, N. Papaioannou, E. Tsetsekou, L. Papadimitriou, C. Masoura, S. Vellas, A. Katinioti, C. Vassiliadou, M. Toutouza-Giotsa, E. Kambaxis, K. Paliou, C. Tselika, S. Poulopoulou and M. Toutouza. 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PD JUL 30 PY 2009 VL 6 AR 30 DI 10.1186/1743-7075-6-30 PG 10 WC Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Nutrition & Dietetics GA 486YD UT WOS:000269236000001 PM 19642977 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Guitart, R Silvestre, AM Guerrero, X Mateo, R AF Guitart, R Silvestre, AM Guerrero, X Mateo, R TI Comparative study on the fatty acid composition of two marine vertebrates: striped dolphins and loggerhead turtles SO COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY LA English DT Article DE arachidonic acid; Caretta caretta; fatty acids; marine mammals; marine turtles; Mediterranean Sea; PUFA; Stenella coeruleoalba ID ORGANOCHLORINE RESIDUES; STENELLA-COERULEOALBA; LIPID-COMPOSITION; TISSUES; SEALS; FISH AB The fatty acid composition of total lipids extracted from seven different tissues (fat, liver, cerebrum, cerebellum, lung, kidney and muscle) of 10 striped dolphins (Stenella coeruleoalba) (weight 75.7 +/- 16.2 kg) found dead or moribund during a morbillivirus epizootic, and from two tissues (fat and liver) of 54 loggerhead turtles (Caretta caretta) (18.5 +/- 10.5 kg) seized dead after illegal capture, both from the Mediterranean Sea, have been determined by high resolution chromatography techniques. When comparing both species, fatty acid composition is surprisingly similar, with a predominance of the monoenoic followed by the saturated group of fatty acids, and a very close ratio of polyunsaturates n-3/n-6. The relatively high arachidonic acid content in the liver of the two marine species is remarkable. The similar diet can play an important role in these findings, but it is suggested that probably metabolic pathways and essential fatty acid requirements between both marine vertebrates are similar, more than is expected from their earlier filogenetic evolutionary divergence. (C) 1999 Elsevier Science Inc. All rights reserved. C1 Univ Autonoma Barcelona, Fac Vet Sci, Toxicol Lab, E-08193 Bellaterra, Spain. C3 Autonomous University of Barcelona RP Guitart, R (通讯作者)，Univ Autonoma Barcelona, Fac Vet Sci, Toxicol Lab, E-08193 Bellaterra, Spain. 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PD DEC PY 1999 VL 124 IS 4 BP 439 EP 443 DI 10.1016/S0305-0491(99)00138-8 PG 5 WC Biochemistry & Molecular Biology; Zoology WE Science Citation Index Expanded (SCI-EXPANDED) SC Biochemistry & Molecular Biology; Zoology GA 263BN UT WOS:000084102900010 PM 10665372 DA 2026-02-02 ER PT J AU Elsayed, A Ismaiel, A Procopio, AC Luzza, F Abenavoli, L Dumitrascu, DL AF Elsayed, Abdalla Ismaiel, Abdulrahman Procopio, Anna C. Luzza, Francesco Abenavoli, Ludovico Dumitrascu, Dan L. TI Noninvasive biochemical markers and surrogate scores in evaluating nonalcoholic steatohepatitis SO MINERVA MEDICA LA English DT Review DE Liver diseases; Inflammation; Fibrosis ID FATTY LIVER-DISEASE; C-REACTIVE PROTEIN; CLINICAL SCORING SYSTEM; MEDITERRANEAN DIET; JAPANESE PATIENTS; ADVANCED FIBROSIS; BIOMARKER PANEL; DIAGNOSIS; NASH; OBESITY AB The histological features of nonalcoholic steatohepatitis (NASH) are the presence of hepatic steatosis with concomitant inflammation, ballooned hepatocytes, and potential fibrosis, which can lead to liver cirrhosis. To reduce the need for liver biopsy, that is still the gold standard for diagnosing NASH, various noninvasive biomarkers have been investigated. This narrative review summarizes the current knowledge about noninvasive diagnostic biomarkers and scores proposed for patients with NASH. A search was performed in the main medical literature databases. The following search terms were used: NASH, noninvasive biomarkers or NASH scores and panels. We focused only on studies assessing NASH diagnosis or predictive values for biomarkers, panels and scores. Data on their accuracy in predicting NASH were collected. Several panels such as NAFLD Fibrosis Score (NFS), Fibrosis-4 (FIB-4), and FibroMeter presented good predictive values of NASH, with novel proteomics panels such as the NAFLD Fibrosis Protein Panel (NFPP) using mainly the adisintegrin and metalloproteinase with thrombospondin motifs like 2 (ADAMTSL2) that showed an advantage in predicting NASH compared to NFS and FIB-4. Another novel panel, Index of NASH (ION) performed better than cytokeratin 18 (CK-18) in excluding severe fibrosis, but the overall accuracy of ION and CK-18 was modest compared to NFS and FIB-4 as it did not provide any significant advantage. Noninvasive biomarkers are currently unable to replace liver biopsy and histological assessment. 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PD OCT PY 2022 VL 113 IS 5 BP 864 EP 874 DI 10.23736/S0026-4806.22.08185-X PG 11 WC Medicine, General & Internal WE Science Citation Index Expanded (SCI-EXPANDED) SC General & Internal Medicine GA 8R4JH UT WOS:000927860000015 PM 35583419 DA 2026-02-02 ER PT J AU Khalil, M Hayek, S Khalil, N Serale, N Vergani, L Calasso, M De Angelis, M Portincasa, P AF Khalil, Mohamad Hayek, Soukayna Khalil, Nour Serale, Nadia Vergani, Laura Calasso, Maria De Angelis, Maria Portincasa, Piero TI Role of Sumac (Rhus coriaria L.) in the management of metabolic syndrome and related disorders: Focus on NAFLD-atherosclerosis interplay SO JOURNAL OF FUNCTIONAL FOODS LA English DT Article DE Rhus coriaria L; (sumac); Functional foods; Metabolic diseases; Medicinal plants; Atherosclerosis ID FATTY LIVER-DISEASE; INTIMA-MEDIA THICKNESS; DIET-INDUCED OBESITY; BODY-MASS INDEX; INSULIN-RESISTANCE; METHYL GALLATE; BLOOD-PRESSURE; GLUCOSE-TOLERANCE; EXTRACT; ACID AB Sumac (Rhus coriaria L.) is a commonly used spice in the Mediterranean region and considered as healthy food ingredients. The beneficial value of sumac is well documented in folk medicine. Accumulating data explored the phytochemical, nutritional and therapeutic proprieties suggesting sumac as a potential functional food. Here, we discuss the general and scientific aspects of sumac. Sumac is rich in different polyphenolic compounds such as flavonoids, tannins, and phenolic acids. The potential therapeutic effects of sumac have been studied in various cellular and animal models, as well as in human. These reports suggest that Sumac has potential effect against oxidative stress, inflammation, obesity, hyperglycemia, hypercholesterolemia, and hyperlipidemia, which represent key pathogenic mechanisms contributing to cardio-metabolic, liver, and cancer diseases. Clinical studies using sumac or its major compounds, suggest that this herbal product may represent a useful therapeutic tool in the management of metabolic-related conditions such as liver-atherosclerosis complications. C1 [Khalil, Mohamad; Portincasa, Piero] Univ Bari, Med Sch, Dept Biomed Sci & Human Oncol, Clin Med A Murri, Piazza Giulio Cesare 11, I-70124 Bari, Italy. [Khalil, Mohamad; Serale, Nadia; Calasso, Maria; De Angelis, Maria] Univ Bari Aldo Moro, Dept Soil Plant & Food Sci, Via Amendola 165-a, I-70126 Bari, Italy. [Hayek, Soukayna] Notre Dame Univ, Fac Nat & Appl Sci, Louaize, Lebanon. [Hayek, Soukayna] Lebanese Univ, Fac Agr Sci, Dekwaneh, Lebanon. [Khalil, Nour] Al Jinan Univ, Fac Publ Hlth, Saida, Lebanon. [Vergani, Laura] Univ Genoa, Dept Earth Environm & Life Sci DISTAV, Corso Europa 26, I-16132 Genoa, Italy. C3 Universita degli Studi di Bari Aldo Moro; Universita degli Studi di Bari Aldo Moro; Notre Dame University Lebanon; University of Genoa RP Portincasa, P (通讯作者)，Univ Bari, Med Sch, Dept Biomed Sci & Human Oncol, Clin Med A Murri, Piazza Giulio Cesare 11, I-70124 Bari, Italy. 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Funct. Food. PD DEC PY 2021 VL 87 AR 104811 DI 10.1016/j.jff.2021.104811 EA OCT 2021 PG 16 WC Food Science & Technology; Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Food Science & Technology; Nutrition & Dietetics GA WN2ZH UT WOS:000711641500004 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Mataix, J Quiles, JL Huertas, JR Battino, M Mañas, M AF Mataix, J Quiles, JL Huertas, JR Battino, M Mañas, M TI Tissue specific interactions of exercise, dietary fatty acids, and vitamin E in lipid peroxidation SO FREE RADICAL BIOLOGY AND MEDICINE LA English DT Article DE olive oil; sunflower oil; hydroperoxides; mitochondria; rat; Mediterranean diet; free radical ID COENZYME-Q; LIQUID-CHROMATOGRAPHY; RAT; MECHANISMS; MEMBRANES; OXIDATION; PLASMA; SERUM AB Both physical exercise and ingestion of polyunsaturated fatty acids that play an essential role in free radical-mediated damages cause lipid peroxidation. The intake of specific fatty acids can modulate the membrane susceptibility to lipid peroxidation. Data confirmed that liver, skeletal muscle, and heart have different capabilities to adapt their membrane composition to dietary fatty acids, the heart being the most resistant to changes. Such specificity affects membrane hydroperoxide levels that depend on the type of dietary fats and the rate of fatty acid incorporation into the membrane. Sedentary rats fed a monounsaturated fatty acid-rich diet (virgin olive oil) showed a higher protection of their mitochondrial membranes against peroxidation than sedentary rats fed a polyunsaturated fatty acid-rich diet (sunflower oil). Rats subjected to training showed higher hydroperoxide contents than sedentary animals, and exhaustive effort enhanced the aforementioned results as well as in vitro peroxidation with a free radical inducer. 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Angeles Zulet, Maria Alfredo Martinez, Jose CA PREDIMED-Plus Investigators TI Relationship of visceral adipose tissue with surrogate insulin resistance and liver markers in individuals with metabolic syndrome chronic complications SO THERAPEUTIC ADVANCES IN ENDOCRINOLOGY AND METABOLISM LA English DT Article DE insulin resistance; metabolic syndrome; non-alcoholic fatty liver disease; triglyceride glucose index; visceral adipose tissue ID NONALCOHOLIC FATTY LIVER; MEDITERRANEAN DIET ADHERENCE; FASTING PLASMA-GLUCOSE; GROWTH-FACTOR 21; SEX-DIFFERENCES; DISEASE; PATHOGENESIS; INDEX; MEN; QUESTIONNAIRE AB Background: Visceral adipose tissue (VAT) has a hazardous influence on systemic inflammation, insulin resistance and an adverse metabolic profile, which increases the risk of developing non-alcoholic fatty liver disease (NAFLD) and chronic complications of diabetes. In our study we aimed to evaluate the association of VAT and the triglyceride glucose (TyG) as a proxy of insulin resistance surrogated with metabolic and liver risk factors among subjects diagnosed with metabolic syndrome (MetS). Methods: A cross-sectional study was performed including 326 participants with MetS (55-75 years) from the PREDIMED-Plus study. Liver-status markers, VAT and TyG were assessed. Participants were stratified by tertiles according to VAT (n = 254) and TyG (n = 326). A receiver operating characteristic curve was used to analyse the efficiency of TyG for VAT. Results: Subjects with greater visceral fat depots showed worse lipid profile, higher homeostatic model assessment for insulin resistance (HOMA-IR), TyG, alanine transaminase (ALT), fibroblast growth factor-21 (FGF-21), fatty liver index (FLI) and hepatic steatosis index (HSI) compared with participants in the first tertile. The multi-adjusted linear-regression analyses indicated that individuals in the third tertile of TyG (>9.1-10.7) had a positive association with HOMA-IR [beta = 3.07 (95% confidence interval (CI) 2.28-3.86; p trend < 0.001)], ALT [beta = 7.43 (95% CI 2.23-12.63; p trend = 0.005)], gamma glutamyl transferase (GGT) [beta = 14.12 (95% CI 3.64-24.61; p trend = 0.008)], FGF-21 [beta = 190.69 (95% CI 93.13-288.25; p trend < 0.001)], FLI [beta = 18.65 (95% CI 14.97-22.23; p trend < 0.001)] and HSI [beta = 3.46 (95% CI, 2.23-4.68; p trend < 0.001)] versus participants from the first tertile. Interestingly, the TyG showed the largest area under the receiver operating curve (AUC) for women (AUC = 0.713; 95% CI 0.62-0.79) compared with men (AUC = 0.570; 95% CI 0.48-0.66). Conclusions: A disrupted VAT enlargement and impairment of TyG are strongly associated with liver status and cardiometabolic risk factors linked with NAFLD in individuals diagnosed with MetS. Moreover, the TyG could be used as a suitable and reliable marker estimator of VAT. C1 [Bullon-Vela, Vanessa; Abete, Itziar; Angeles Zulet, Maria; Alfredo Martinez, Jose] Univ Navarra, Dept Nutr Food Sci & Physiol, Ctr Nutr Res, Irunlarrea 1, Pamplona 31008, Spain. [Abete, Itziar; Tur, Josep A.; Konieczna, Jadwiga; Romaguera, Dora; Pinto, Xavier; Corbella, Emili; Martinez-Gonzalez, Miguel A.; Sayon-Orea, Carmen; Toledo, Estefania; Corella, Dolores; Macias-Gonzalez, Manuel; Tinahones, Francisco J.; Fito, Montserrat; Estruch, Ramon; Ros, Emilio; Salas-Salvado, Jordi; Mascaro, Catalina M.; Angeles Zulet, Maria; Alfredo Martinez, Jose] Inst Hlth Carlos III ISCIII, Consorcio CIBER, MP Fisiopatol Obesidad & Nutr CIBERobn, Madrid, Spain. [Abete, Itziar; Martinez-Gonzalez, Miguel A.; Sayon-Orea, Carmen; Toledo, Estefania; Angeles Zulet, Maria; Alfredo Martinez, Jose] Navarra Inst Hlth Res IdiSNA, Pamplona, Spain. [Abete, Itziar] Inst Hlth Carlos III, CIBER Fisiopatol Obesidad & Nutr CIBERobn, Madrid, Spain. [Tur, Josep A.; Mascaro, Catalina M.] Univ Balearic Isl, Res Grp Community Nutr & Oxidat Stress, Palma De Mallorca, Spain. [Tur, Josep A.; Mascaro, Catalina M.] Hlth Res Inst Balearic Isl IdISBa, Palma De Mallorca, Spain. [Konieczna, Jadwiga; Romaguera, Dora] Univ Hosp Balearic Isl, Res Grp Nutr Epidemiol & Cardiovasc Physiopathol, Hlth Res Inst Balearic Isl IdIsBa, Palma De Mallorca, Spain. [Pinto, Xavier; Corbella, Emili] Hosp Univ Bellvitge, Lipids & Vasc Risk Unit, Internal Med, Barcelona, Spain. [Martinez-Gonzalez, Miguel A.; Sayon-Orea, Carmen; Toledo, Estefania] Univ Navarra, Dept Prevent Med & Publ Hlth, Pamplona, Spain. [Corella, Dolores] Univ Valencia, Dept Prevent Med, Valencia, Spain. [Macias-Gonzalez, Manuel; Tinahones, Francisco J.] Univ Malaga, Virgen de la Victoria Hosp, Inst Biomed Res Malaga IBIMA, Dept Endocrinol, Malaga, Spain. [Fito, Montserrat] Hosp del Mar Res Inst IMIM, Cardiovasc Risk & Nutr Res Grp CARIN, Barcelona, Spain. [Estruch, Ramon] Univ Barcelona, Dept Internal Med, Barcelona, Spain. [Ros, Emilio] Inst Invest Biomed August Pi Sunyer IDIBAPS, Dept Endocrinol & Nutr, Barcelona, Spain. [Salas-Salvado, Jordi] Unversitat Rovira & Virgili, Unitat Nutr Humana, Dept Bioquim & Biotecnol, Reus, Spain. [Salas-Salvado, Jordi] Hosp Univ St Joan Reus, Inst Invest Pere Virgili IISPV, Reus, Spain. [Daimiel, Lidia; Alfredo Martinez, Jose] CEI UAM CSIC, Precis Nutr Programme, IMDEA Food, Madrid, Spain. C3 University of Navarra; University of Navarra; CIBER - Centro de Investigacion Biomedica en Red; CIBEROBN; Universitat de les Illes Balears; Institut Investigacio Sanitaria Illes Balears (IdISBa); Institut Investigacio Sanitaria Illes Balears (IdISBa); Institut d'Investigacio Biomedica de Bellvitge (IDIBELL); Bellvitge University Hospital; University of Barcelona; University of Navarra; University of Valencia; Universidad de Malaga; IBIMA Plataforma BIONAND, Instituto de Investigacion Biomedica de Malaga; Hospital del Mar Research Institute; Hospital del Mar; University of Barcelona; University of Barcelona; Hospital Clinic de Barcelona; IDIBAPS; Universitat Rovira i Virgili; Institut d'Investigacio Sanitaria Pere Virgili (IISPV); Consejo Superior de Investigaciones Cientificas (CSIC); IMDEA Food Institute RP Abete, I (通讯作者)，Univ Navarra, Dept Nutr Food Sci & Physiol, Ctr Nutr Res, Irunlarrea 1, Pamplona 31008, Spain.; Abete, I (通讯作者)，Inst Hlth Carlos III ISCIII, Consorcio CIBER, MP Fisiopatol Obesidad & Nutr CIBERobn, Madrid, Spain.; Abete, I (通讯作者)，Navarra Inst Hlth Res IdiSNA, Pamplona, Spain.; Abete, I (通讯作者)，Inst Hlth Carlos III, CIBER Fisiopatol Obesidad & Nutr CIBERobn, Madrid, Spain. EM iabetego@unav.es RI Tinahones, Francisco J/AAB-2882-2020; Pintó Sala, Xavier/AGI-4297-2022; Daimiel-Ruiz, Lidia Ángeles/M-7779-2014; Salas-Salvadó, Jordi/C-7229-2017; Bullón-Vela, Vanessa/AFR-2561-2022; Estruch, Ramon/AAZ-3723-2020; Macias-Gonzalez, Manuel/E-7584-2016; Sayon-Orea, Carmen/A-9828-2017; Fito, Montserrat/C-1822-2012; Corbella, Emili/AGI-4105-2022; Konieczna, Jadwiga/AAB-2817-2020; Toledo, Estefania/H-6211-2014; Romaguera, Dora/ABE-7004-2020; Corella, Dolores/L-9888-2014; Martinez-Gonzalez, Miguel/AAE-7669-2019; Tur, Josep/AAE-5748-2020 OI Tinahones, Francisco J/0000-0001-6871-4403; Pintó Sala, Xavier/0000-0002-2216-2444; Daimiel-Ruiz, Lidia Ángeles/0000-0001-9898-6629; Salas-Salvadó, Jordi/0000-0003-2700-7459; Sayon-Orea, Carmen/0000-0002-4137-3263; Corbella, Emili/0000-0001-8818-1907; FU European Research Council [340918]; CIBER Fisiopatologia de la Obesidad y Nutricion (CIBERobn); Instituto de Salud Carlos III (ISCIII) through the Fondo de Investigacion para la Salud (FIS) - European Regional Development Fund [PI13/00673, PI13/00492, PI13/00272, PI13/01123, PI13/00462, PI13/00233, PI13/02184, PI13/00728, PI13/01090, PI13/01056, PI14/01722, PI14/00636, PI14/00618, PI14/00696, PI14/01206, PI14/01919, PI14/00853, PI14/01374, PI14/00972, PI14/00728]; Especial Action Project 'Implementacion y evaluacion de una intervencion intensiva sobre la actividad fisica Cohorte PREDIMED-Plus'; Recercaixa [2013ACUP00194]; ICREA under the ICREA Academia program; SEMERGEN grant; International Nut and Dried Fruit Council-FESNAD (Long-term effects of an energy-restricted Mediterranean diet on mortality and cardiovascular disease 2014-015) [201302]; AstraZeneca Young Investigators Award in Category of Obesity and T2D 2017; Consejeria de Salud de la Junta de Andalucia [PI0458/2013, PS0358/2016, PI0137/2018]; Generalitat Valenciana [PROMETEO/2017/017]; Balearic Islands Gov [35/2011]; FEDER funds [35/2011]; Ministry of Education, Spain; Centre for Nutrition Research of the University of Navarra; ISCIII through the Fondo de Investigacion para la Salud (FIS) - European Regional Development Fund [PI19/00309, PI19/01032, PI19/00576, PI19/00017, PI19/01226, PI19/00781, PI19/01560, PI19/01332, PI17/00532, PI17/00215, PI17/01441, PI17/00508, PI17/01732, PI17/00926, PI19/00957, PI19/00386, PI17/00764, PI17/01183]; the ISCIII through the Fondo de Investigacion para la Salud (FIS) - European Regional Development Fund [PI16/00366, PI16/01522, PI16/01120, PI14/01471, PI16/00473, PI16/00662, PI16/01873, PI17/00855, PI17/01347, PI17/00525, PI17/01827, PI16/01094, PI16/00501, PI16/00533, PI16/00381] FX The authors disclose receipt of the following financial support for the research, authorship, and/or publication of this article: the PREDIMED-Plus trial was supported by the European Research Council (Advanced Research grant 2014-2019; agreement #340918; granted to Dr MartinezGonzalez); the official Spanish institutions for funding scientific biomedical research, CIBER Fisiopatologia de la Obesidad y Nutricion (CIBERobn) and Instituto de Salud Carlos III (ISCIII) through the Fondo de Investigacion para la Salud (FIS) that is co-funded by the European Regional Development Fund (coordinated FIS projects led by Drs Salas-Salvado and Vidal, including the following projects: PI13/00673, PI13/00492, PI13/00272, PI13/01123, PI13/00462, PI13/00233, PI13/02184, PI13/00728, PI13/01090, PI13/01056, PI14/01722, PI14/00636, PI14/00618, PI14/00696, PI14/01206, PI14/01919, PI14/00853, PI14/01374, PI14/00972, PI14/00728, PI14/01471, PI16/00473, PI16/00662, PI16/01873, PI16/01094, PI16/00501, PI16/00533, PI16/00381, PI16/00366, PI16/01522, PI16/01120, PI17/00764, PI17/01183, PI17/00855, PI17/01347, PI17/00525, PI17/01827, PI17/00532, PI17/00215, PI17/01441, PI17/00508, PI17/01732, PI17/00926, PI19/00957, PI19/00386, PI19/00309, PI19/01032, PI19/00576, PI19/00017, PI19/01226, PI19/00781, PI19/01560, PI19/01332) and the Especial Action Project 'Implementacion y evaluacion de una intervencion intensiva sobre la actividad fisica Cohorte PREDIMED-Plus' (Dr Salas-Salvado); the Recercaixa (grant number 2013ACUP00194) (Dr Salas-Salvado); J. Salas-Salvado, gratefully acknowledges the financial suuport by ICREA under the ICREA Academia program; the SEMERGEN grant; International Nut and Dried Fruit Council-FESNAD (Long-term effects of an energy-restricted Mediterranean diet on mortality and cardiovascular disease 2014-015; no. 201302; Dr Martinez-Gonzalez); the AstraZeneca Young Investigators Award in Category of Obesity and T2D 2017 (Dr Romaguera); grants from the Consejeria de Salud de la Junta de Andalucia (PI0458/2013; PS0358/2016; PI0137/2018), the PROMETEO/2017/017 grant from the Generalitat Valenciana, the SEMERGEN grant; grant of support to research groups 35/2011 (Balearic Islands Gov; FEDER funds; Drs Tur and Bouz). JK is contracted for the `FOLIUM' programme within the FUTURMed project. Talent for the medicine within the future from the Fundacion Instituto de Investigacion Sanitaria Illes Balears (financed by 2017 annual plan of the sustainable tourism tax and at 50% with charge to the ESF Operational Programme 2014-2020 of the Balearic Islands). CMM received an FPU grant from the Ministry of Education, Spain. VB-V received a grant from the Centre for Nutrition Research of the University of Navarra. 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Adv. Endocrinol. Metab. PD OCT PY 2020 VL 11 AR 2042018820958298 DI 10.1177/2042018820958298 PG 15 WC Endocrinology & Metabolism WE Science Citation Index Expanded (SCI-EXPANDED) SC Endocrinology & Metabolism GA ON3CJ UT WOS:000586583200001 PM 33149882 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Vitale, M Della Pepa, G Costabile, G Bozzetto, L Cipriano, P Signorini, S Leoni, V Riccardi, G Vaccaro, O Masulli, M AF Vitale, Marilena Della Pepa, Giuseppe Costabile, Giuseppina Bozzetto, Lutgarda Cipriano, Paola Signorini, Stefano Leoni, Valerio Riccardi, Gabriele Vaccaro, Olga Masulli, Maria TI Association between Diet Quality and Index of Non-Alcoholic Steatohepatitis in a Large Population of People with Type 2 Diabetes: Data from the TOSCA.IT Study SO NUTRIENTS LA English DT Article DE type 2 diabetes; NASH; micronutrients; macronutrients; dietary habits; foods groups; Mediterranean diet; dietary patterns ID FATTY LIVER-DISEASE; CARDIOVASCULAR EVENTS; POLYPHENOLS; MANAGEMENT; NUTRITION; IMPACT; NAFLD; PIOGLITAZONE; ADHERENCE; METFORMIN AB Background: There are still open questions with respect to the optimal dietary treatment in patients with type 2 diabetes (T2D) and coexisting non-alcoholic steatohepatitis (NASH). The aim of this study is to investigate, in patients with T2D, the association between NASH, dietary component intake, food groups and adherence to the Mediterranean diet. Methods: Cross-sectional analysis of 2026 people with T2D (1136 men and 890 women). The dietary habits were assessed with the European Prospective Investigation into Cancer and Nutrition (EPIC) questionnaire. NASH was identified by the Index Of NASH (ION). Based on the cluster analysis two dietary patterns were identified: the NASH and the NO-NASH pattern. Results: The macronutrient composition of the diet was similar in the two patterns. However, the NASH pattern compared with the NO-NASH pattern was characterized by a significantly lower content of fibre (p < 0.001), beta-carotene (p < 0.001), vitamin C (p < 0.001), vitamin E (p < 0.001), polyphenols (p = 0.026) and antioxidant capacity (p < 0.001). With regard to food consumption, the NASH pattern compared with NO-NASH pattern was characterized by higher intake of rice (p = 0.021), potatoes (p = 0.013), red (p = 0.004) and processed meat (p = 0.003), and a lower intake of wholegrain bread (p = 0.019), legumes and nuts (p = 0.049), vegetables (p = 0.047), fruits (p = 0.002), white meat (p = 0.001), fatty fish (p = 0.005), milk and yogurt (p < 0.001). Conclusions: NO-NASH dietary pattern was characterized by a food consumption close to the Mediterranean dietary model, resulting in a higher content of polyphenols, vitamins, and fibre. These finding highlight the potential for dietary components in the prevention/treatment of NASH in people with T2D. C1 [Vitale, Marilena; Della Pepa, Giuseppe; Costabile, Giuseppina; Bozzetto, Lutgarda; Cipriano, Paola; Riccardi, Gabriele; Vaccaro, Olga; Masulli, Maria] Univ Naples Federico II, Dept Clin Med & Surg, I-80131 Naples, Italy. [Signorini, Stefano; Leoni, Valerio] Hosp Pius XI Desio, Lab Clin Biochem, ASST Brianza, I-20833 Desio, Italy. [Leoni, Valerio] Univ Milano Bicocca, Dept Med & Surg, I-20216 Monza, Italy. C3 University of Naples Federico II; University of Milano-Bicocca RP Vaccaro, O (通讯作者)，Univ Naples Federico II, Dept Clin Med & Surg, I-80131 Naples, Italy. EM ovaccaro@unina.it RI Ciampalini, Paolo/K-4366-2016; Bozzetto, Lutgarda/E-6271-2012; Vitale, Marilena/J-1457-2014; Costabile, Giuseppina/AAJ-8382-2020; Della Pepa, Giuseppe/AAK-5488-2020; LEONI, VALERIO/AAC-1652-2019 OI Bozzetto, Lutgarda/0000-0001-6549-4476; Vitale, Marilena/0000-0001-9951-4674; Costabile, Giuseppina/0000-0001-5761-8002; Della Pepa, Giuseppe/0000-0001-5862-3794; Gregori, Giovanna/0000-0002-3566-4363; LEONI, VALERIO/0000-0002-8954-0366; vaccaro, olga/0000-0002-1083-1428 FU Italian Medicines Agency (AIFA); Diabete Ricerca [FARM6T9CET]; Non-profit Research Foundation of the Italian Diabetes Society FX The study was supported by the Italian Medicines Agency (AIFA) within the Independent Drug Research Program-contract number FARM6T9CET-and by Diabete Ricerca, the non-profit Research Foundation of the Italian Diabetes Society. The funding agency played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the manuscript; or in the decision to submit the manuscript for publication CR Abe RAM, 2021, CUREUS J MED SCIENCE, V13, DOI 10.7759/cureus.16855 Abenavoli L, 2021, NUTRIENTS, V13, DOI 10.3390/nu13020494 Akhlaghi M, 2020, J DIABETES METAB DIS, V19, P575, DOI 10.1007/s40200-019-00475-2 [Anonymous], 2000, TABELLA COMPOSIZIONE Bayram HM, 2021, CLIN NUTR ESPEN, V44, P1, DOI 10.1016/j.clnesp.2021.06.026 Berná G, 2020, LIVER INT, V40, P102, DOI 10.1111/liv.14360 Bhagwat S., 2014, USDA DATABASE FLAVON Bozzetto L, 2016, NUTR METAB CARDIOVAS, V26, P623, DOI 10.1016/j.numecd.2016.01.011 Bril F, 2017, DIABETES CARE, V40, P419, DOI 10.2337/dc16-1787 Buckland G, 2009, AM J EPIDEMIOL, V170, P1518, DOI 10.1093/aje/kwp282 Castera L, 2019, GASTROENTEROLOGY, V156, P1264, DOI 10.1053/j.gastro.2018.12.036 Chung M, 2014, AM J CLIN NUTR, V100, P833, DOI 10.3945/ajcn.114.086314 Cotter TG, 2020, GASTROENTEROLOGY, V158, P1851, DOI 10.1053/j.gastro.2020.01.052 Cusi K, 2020, DIABETES CARE, V43, P275, DOI 10.2337/dci19-0064 Della Pepa G, 2017, NUTRIENTS, V9, DOI 10.3390/nu9101065 Diehl AM, 2017, NEW ENGL J MED, V377, P2063, DOI 10.1056/NEJMra1503519 EASL, 2016, OBESITY FACTS, V9, P65, DOI 10.1159/000443344 Etemadi A., 2020, CURR DEV NUTR, V4, P1413, DOI 10.1093/cdn/nzaa061_041 Evert AB, 2019, DIABETES CARE, V42, P731, DOI 10.2337/dci19-0014 Fan JG, 2013, J GASTROEN HEPATOL, V28, P81, DOI 10.1111/jgh.12244 Gastaldelli A, 2019, JHEP REP, V1, P312, DOI 10.1016/j.jhepr.2019.07.002 Hazlehurst JM, 2016, METABOLISM, V65, P1096, DOI 10.1016/j.metabol.2016.01.001 He KY, 2020, BRIT J NUTR, V124, P1, DOI 10.1017/S0007114520000914 Hou LY, 2023, CAN J DIABETES, V47, P197, DOI 10.1016/j.jcjd.2022.08.005 Iqbal Umair, 2019, Medicines (Basel), V6, DOI [10.3390/medicines6010041, 10.3390/medicines6010041] Ivancovsky-Wajcman D, 2019, DIGEST LIVER DIS, V51, P1698, DOI 10.1016/j.dld.2019.06.005 Jensen T, 2018, J HEPATOL, V68, P1063, DOI 10.1016/j.jhep.2018.01.019 Lazarus JV, 2020, NAT REV GASTRO HEPAT, V17, P377, DOI 10.1038/s41575-020-0315-7 Lomonaco R, 2016, DIABETES CARE, V39, P632, DOI 10.2337/dc15-1876 Otgonsuren M, 2014, J GASTROEN HEPATOL, V29, P2006, DOI 10.1111/jgh.12665 Pala V, 2003, TUMORI J, V89, P594, DOI 10.1177/030089160308900603 Parry SA, 2020, ADV THER, V37, P1381, DOI 10.1007/s12325-020-01281-6 Perdomo CM, 2019, NUTRIENTS, V11, DOI 10.3390/nu11030677 de Oca APM, 2020, NUTRIENTS, V12, DOI 10.3390/nu12103100 Pisani P, 1997, INT J EPIDEMIOL, V26, pS152, DOI 10.1093/ije/26.suppl_1.S152 Rodriguez-Ramiro I, 2016, P NUTR SOC, V75, P47, DOI 10.1017/S0029665115004218 Rothwell JA, 2013, DATABASE-OXFORD, DOI 10.1093/database/bat070 Salehi-sahlabadi A, 2021, CLIN NUTR ESPEN, V41, P429, DOI 10.1016/j.clnesp.2020.09.028 Salvini S., 1998, Banca dati di composizionedeglialimenti per studiepidemiologici in Italia. 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Gonzalez-Gil, Esther M. Marcos, Ascension Widhalm, Kurt Molnar, Denes Manios, Yannis Gottrand, Frederic Kafatos, Anthony Kersting, Mathilde Sjostrom, Michael Amaro-Gahete, Francisco J. Ferrari, Marika Huybrechts, Inge Gonzalez-Gross, Marcela De Henauw, Stefaan Michels, Nathalie TI Diet as moderator in the association of adiposity with inflammatory biomarkers among adolescents in the HELENA study SO EUROPEAN JOURNAL OF NUTRITION LA English DT Article DE Low-grade inflammation; Adiposity; Mediterranean diet score; Adolescents ID POLYUNSATURATED FATTY-ACIDS; GAMMA-GLUTAMYL-TRANSFERASE; HEALTHY LIFE-STYLE; MEDITERRANEAN DIET; ALANINE AMINOTRANSFERASE; EUROPEAN ADOLESCENTS; LIVER-DISEASE; BODY-FAT; INCREASED RISK; CHILDREN AB Aim Our aim is to demonstrate that a healthy diet might reduce the relation between adiposity and inflammation, whereas an unhealthy diet may increase the effect of adiposity on inflammatory biomarkers. Methods In 618 adolescents (13-17years) of the European HELENA study, data were available on body composition, a set of inflammation markers, and food intake determined by a self-administered computerized 24-h recall. A 9-point Mediterranean diet score and an antioxidant-rich diet score were used as dietary parameters and tested as moderator. Total body fat was represented by the sum of six skinfold thicknesses and central adiposity by waist circumference. A set of inflammation-related biomarkers was used as outcome: a pro/anti-inflammatory interleukins ratio, TGF beta-1, C-reactive protein, TNF-alpha, 3 cell adhesion molecules, and 3 types of immune cells; gamma-glutamyltransferase (GGT) and homocysteine were used as cardiovascular disease risk biomarkers, and alanine transaminase (ALT) as liver dysfunction biomarker. Multiple linear regression analyses tested moderation by diet in the adiposity-inflammation association and were adjusted for age, sex, country, puberty, socioeconomic status. Results Both the Mediterranean and antioxidant-rich diet, and overall and central adiposity, were important in the moderation. Diet was a significant protective moderator in the effect of adiposity on the pro/anti-inflammatory interleukins ratio, TGF beta-1, GGT, and ALT. Conclusion In conclusion, in some cases, a diet rich in antioxidants and essential nutrients may attenuate the concentration of inflammatory biomarkers caused by adiposity, whereas a poor diet appears to contribute to the onset of early oxidative stress signs. C1 [Arouca, Aline; Huybrechts, Inge; De Henauw, Stefaan; Michels, Nathalie] Univ Ghent, Dept Publ Hlth, Fac Med & Hlth Sci, De Pintelaan 185,Block K3,4th Floor, B-9000 Ghent, Belgium. [Moreno, Luis A.; Gonzalez-Gil, Esther M.] Univ Zaragoza, Inst Agroalimentario Aragon IA2, Inst Invest Sanitaria Aragon IIS Aragon, GENUD Growth Exercise Nutr & Dev Res Grp,Fac Cien, Zaragoza, Spain. [Moreno, Luis A.; Gonzalez-Gil, Esther M.] Ctr Invest Biomed Red Fisiopatol Obesidad & Nutri, Santiago De Compostela, Spain. [Marcos, Ascension] Inst Food Sci & Technol & Nutr, Dept Metab & Nutr, Madrid, Spain. [Widhalm, Kurt] Med Univ Vienna, Dept Pediat, Div Nutr & Metab, Vienna, Austria. [Molnar, Denes] Univ Pecs, Med Sch, Dept Pediat, Pecs, Hungary. [Manios, Yannis] Harokopio Univ, Sch Hlth Sci Sr Educ, Dept Nutr & Dietet, Athens, Greece. [Gottrand, Frederic] Univ Lille, Fac Med, Lille, France. [Kafatos, Anthony] Univ Crete, Fac Med, Iraklion, Greece. [Kersting, Mathilde] Ruhr Univ Bochum, Pediat Univ Clin, Res Dept Inst Child Nutr Dortmund, Bochum, Germany. [Sjostrom, Michael] Karolinska Inst, Unit Prevent Nutr, Dept Biosci, Huddinge, Sweden. [Amaro-Gahete, Francisco J.] Univ Granada, Sch Med, Dept Med Physiol, Granada, Spain. [Ferrari, Marika] Res Ctr Food & Nutr, Council Agr Res & Econ, Rome, Italy. [Huybrechts, Inge] Int Agcy Res Canc, Lyon, France. [Gonzalez-Gross, Marcela] Univ Politecn Madrid, Fac Ciencias Actividad Fis & Deporte INEF, Dept Hlth & Human Performance, ImFINE Res Grp, Madrid, Spain. C3 Ghent University; Ghent University Hospital; University of Zaragoza; CIBER - Centro de Investigacion Biomedica en Red; CIBEROBN; Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Instituto de Ciencia y Tecnologia de Alimentos y Nutricion (ICTAN); Medical University of Vienna; University of Pecs; Harokopio University Athens; Universite de Lille; University of Crete; Ruhr University Bochum; Karolinska Institutet; University of Granada; Consiglio per la Ricerca in Agricoltura e L'analisi Dell'economia Agraria (CREA); World Health Organization; International Agency for Research on Cancer (IARC); Universidad Politecnica de Madrid RP Arouca, A; Michels, N (通讯作者)，Univ Ghent, Dept Publ Hlth, Fac Med & Hlth Sci, De Pintelaan 185,Block K3,4th Floor, B-9000 Ghent, Belgium. EM aline.barbedoarouca@ugent.be; nathalie.michels@ugent.be RI Michels, Nathalie/C-2819-2012; Manios, Yannis/AAM-8953-2021; Amaro-Gahete, Francisco J/AAB-4476-2019; Gonzalez-Gross, Marcela/W-8000-2018; gottrand, frederic/W-8000-2018; Sanchez, Ascension/K-4965-2014; Arouca, Aline/E-7118-2016; Huybrechts, Inge/ITT-7052-2023; Moreno Aznar, Luis A/S-1780-2019; gottrand, frederic/G-7370-2015; González Gil, Esther María/AAA-8040-2020; Molnár, Dénes/AAB-6820-2022 OI Michels, Nathalie/0000-0002-3069-7254; Manios, Yannis/0000-0001-6486-114X; Amaro-Gahete, Francisco J/0000-0002-7207-9016; Gonzalez-Gross, Marcela/0000-0001-7757-3235; gottrand, frederic/0000-0002-5290-0436; Moreno Aznar, Luis A/0000-0003-0454-653X; gottrand, frederic/0000-0002-5290-0436; González Gil, Esther María/0000-0003-2005-8229; FU European Community Sixth RTD Framework Programme [FOODCT-2005-007034] FX The HELENA Study was carried out with the financial support of the European Community Sixth RTD Framework Programme (Contract FOODCT-2005-007034). The writing group takes sole responsibility for the content of this article. The European Community is not liable for any use that may be made of the information contained therein. 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PD AUG PY 2019 VL 58 IS 5 BP 1947 EP 1960 DI 10.1007/s00394-018-1749-3 PG 14 WC Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI) SC Nutrition & Dietetics GA IK3MJ UT WOS:000476492800017 PM 29948222 OA Green Submitted DA 2026-02-02 ER PT J AU Gonçalves-de-Albuquerque, CF Medeiros-de-Moraes, IM Oliveira, FMD Burth, P Bozza, PT Faria, MVC Silva, AR de Castro-Faria-Neto, HC AF Goncalves-de-Albuquerque, Cassiano Felippe Medeiros-de-Moraes, Isabel Matos de Jesus Oliveira, Flora Magno Burth, Patricia Bozza, Patricia Torres Castro Faria, Mauro Velho Silva, Adriana Ribeiro de Castro-Faria-Neto, Hugo Caire TI Omega-9 Oleic Acid Induces Fatty Acid Oxidation and Decreases Organ Dysfunction and Mortality in Experimental Sepsis SO PLOS ONE LA English DT Article ID PROLIFERATOR-ACTIVATED RECEPTORS; CRITICALLY-ILL PATIENTS; OLIVE OIL; UNCOUPLING PROTEIN-2; LIPID-METABOLISM; ENDOTOXIC-SHOCK; MEDITERRANEAN DIET; SIGNALING PATHWAY; NUCLEAR RECEPTORS; CECAL LIGATION AB Sepsis is characterized by inflammatory and metabolic alterations, which lead to massive cytokine production, oxidative stress and organ dysfunction. In severe systemic inflammatory response syndrome, plasma non-esterified fatty acids (NEFA) are increased. Several NEFA are deleterious to cells, activate Toll-like receptors and inhibit Na+/K+-ATPase, causing lung injury. A Mediterranean diet rich in olive oil is beneficial. The main component of olive oil is omega-9 oleic acid (OA), a monounsaturated fatty acid (MUFA). We analyzed the effect of OA supplementation on sepsis. OA ameliorated clinical symptoms, increased the survival rate, prevented liver and kidney injury and decreased NEFA plasma levels in mice subjected to cecal ligation and puncture (CLP). OA did not alter food intake and weight gain but diminished reactive oxygen species (ROS) production and NEFA plasma levels. Carnitine palmitoyltransferase IA (CPT1A) mRNA levels were increased, while uncoupling protein 2 (UCP2) liver expression was enhanced in mice treated with OA. OA also inhibited the decrease in 5' AMP-activated protein kinase (AMPK) expression and increased the enzyme expression in the liver of OA-treated mice compared to septic animals. We showed that OA pretreatment decreased NEFA concentration and increased CPT1A and UCP2 and AMPK levels, decreasing ROS production. We suggest that OA has a beneficial role in sepsis by decreasing metabolic dysfunction, supporting the benefits of diets high in monounsaturated fatty acids (MUFA). C1 [Goncalves-de-Albuquerque, Cassiano Felippe; Medeiros-de-Moraes, Isabel Matos; de Jesus Oliveira, Flora Magno; Bozza, Patricia Torres; Silva, Adriana Ribeiro; de Castro-Faria-Neto, Hugo Caire] Fiocruz MS, Inst Oswaldo Cruz, Lab Imunofarmacol, BR-21040900 Rio De Janeiro, RJ, Brazil. [Burth, Patricia] Univ Fed Fluminense, Inst Biol, Dept Biol Celular & Mol, BR-2402015 Niteroi, RJ, Brazil. [Castro Faria, Mauro Velho] Univ Estado Rio de Janeiro, Fac Ciencias Med, Dept Med Interna, BR-20550900 Rio De Janeiro, RJ, Brazil. [de Castro-Faria-Neto, Hugo Caire] Univ Estacio Sa, Programa Produtividade Cient, Rio De Janeiro, RJ, Brazil. C3 Fundacao Oswaldo Cruz; Universidade Federal Fluminense; Universidade do Estado do Rio de Janeiro; Universidade Estacio de Sa RP de Castro-Faria-Neto, HC (通讯作者)，Fiocruz MS, Inst Oswaldo Cruz, Lab Imunofarmacol, BR-21040900 Rio De Janeiro, RJ, Brazil. EM arsilva71@gmail.com; hugocfneto@gmail.com RI Burth, Patricia/N-8180-2017; Ribeiro Silva, Aiana/NBW-8392-2025; Gonçalves-de-Albuquerque, Cassiano Felippe/N-2815-2014; Bozza, Patricia/AAE-2933-2021 OI Ribeiro Silva, Aiana/0000-0002-5137-4251; Gonçalves-de-Albuquerque, Cassiano Felippe/0000-0002-4458-3055; Bozza, Patricia/0000-0001-8349-9529 FU Fundacao de Amparo a Pesquisa do Estado do Rio de Janeiro (FAPERJ); Programa Estrategico de Apoio a Pesquisa em Saude (PAPES)-FIOCRUZ; Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) FX This work was supported by Fundacao de Amparo a Pesquisa do Estado do Rio de Janeiro (FAPERJ)-MVCF, PB, HCCFN; Programa Estrategico de Apoio a Pesquisa em Saude (PAPES)-FIOCRUZ- PTB, ARS, HCCFN; and Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)-PB, PTB, ARS, MVCF, HCCFN. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. 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Willis, JL Boehm, GW Chumley, MJ AF Braden-Kuhle, Paige N. Lacy, Vivienne A. Brice, Kelly N. Bertrand, Morgan E. Uras, Hatice Buse Shoffner, Catherine Fischer, Bridgette E. Rana, Ashish Willis, Jada L. Boehm, Gary W. Chumley, Michael J. TI A Mediterranean-style diet protects against cognitive and behavioral deficits, adiposity, and Alzheimer's disease-related markers, compared to a macronutrient-matched typical American diet in C57BL/6J mice SO JOURNAL OF ALZHEIMERS DISEASE LA English DT Article DE Alzheimer's disease; amyloid-beta; anxiety-like behavior; cytokines; fatty liver; macronutrient-matched; Mediterranean diet; plant-based; spatial memory; Western diet ID HIGH-FAT DIET; VIRGIN OLIVE OIL; BETA-AMYLOID ACCUMULATION; WESTERN DIET; DOCOSAHEXAENOIC ACID; A-BETA; LIVER-DISEASE; ANIMAL-MODEL; SERUM-LEVELS; BODY-WEIGHT AB Background Research suggests that modifying risk factors may prevent or delay up to 40% of dementia cases, including Alzheimer's disease (AD). Thus, understanding the potential of healthful dietary patterns, like the Mediterranean diet (MD), in AD prevention is crucial. While supplementation of individual Mediterranean foods has demonstrated efficacy in reducing AD biomarkers and cognitive impairment in rodents, the effects of a comprehensive MD warrant further investigation. Additionally, while rodent studies often use a "Western diet" as a model for the typical American diet (TAD), these diets generally exceed the macronutrient densities of typical American consumption, particularly in fats and carbohydrates. Objective To better reflect human diets, we developed two diets for mice that more closely mirrored the macronutrient composition of the traditional MD or the TAD, each with matched macronutrient profiles (50% kcal from carbohydrates, 35% kcal from fat, 15% kcal from protein), and distinct food sources from Mediterranean regions or the U.S., respectively. Methods Male C57BL/6J mice were randomly assigned to one diet (MD or TAD) at weaning (21 days of age), which they consumed for six months. Results Compared to the TAD, MD animals had lower body weight, abdominal and hepatic fat, serum TNF-alpha, and central A beta(1-42), while also exhibiting enhanced exploratory behavior, reduced anxiety-like behavior, and preserved spatial memory. The MD also protected against LPS-induced central inflammation and BDNF loss. Conclusions These findings suggest that a comprehensive MD provides protection against metabolic and AD-related markers in wildtype mice, despite matched caloric availability to the TAD. C1 [Braden-Kuhle, Paige N.] Vanguard Univ Southern Calif, Dept Psychol, 55 Fair Dr, Costa Mesa, CA 92626 USA. [Lacy, Vivienne A.; Bertrand, Morgan E.; Fischer, Bridgette E.; Chumley, Michael J.] Texas Christian Univ, Dept Biol, Ft Worth, TX USA. [Brice, Kelly N.] Rice Univ, Dept Psychol Sci, Houston, TX USA. [Uras, Hatice Buse; Shoffner, Catherine; Rana, Ashish; Boehm, Gary W.] Texas Christian Univ, Dept Psychol, Ft Worth, TX USA. [Willis, Jada L.] Texas Christian Univ, Dept Nutr Sci, Ft Worth, TX USA. C3 Vanguard University Southern California; Texas Christian University; Rice University; Texas Christian University; Texas Christian University RP Braden-Kuhle, PN (通讯作者)，Vanguard Univ Southern Calif, Dept Psychol, 55 Fair Dr, Costa Mesa, CA 92626 USA. EM paige.kuhle@vanguard.edu OI , Morgan Elizabeth Bertrand/0009-0006-0551-3878; Shoffner, Catherine/0009-0004-9435-1174; Lacy, Vivienne/0000-0003-3766-0478; Kuhle, Paige/0000-0001-9229-3901 FU TCU Invests in Scholarship Grant; Graduate and Undergraduate Science and Engineering Research Center Grants, Texas Christian University FX The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: TCU Invests in Scholarship Grant, The transgenerational effects of diet on gene expression, microbiome, and prevention of Alzheimer's disease, 06/2022-06/2023, $20,000, PIs: Dr Michael Chumley (TCU), Dr Gary Boehm (TCU), Dr Jada Willis (TCU), Dr Matthew Hale (TCU), and Dr Michael Allen (UNTHSC). Graduate and Undergraduate Science and Engineering Research Center Grants, Texas Christian University (2021-2023). 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Alzheimers Dis. PD APR PY 2025 VL 104 IS 3 BP 678 EP 697 DI 10.1177/13872877251319467 EA FEB 2025 PG 20 WC Neurosciences WE Science Citation Index Expanded (SCI-EXPANDED) SC Neurosciences & Neurology GA 1JS8R UT WOS:001460462700001 PM 40007076 OA Bronze DA 2026-02-02 ER PT J AU Gutiérrez, GR de Roos, B AF Rodriguez Gutierrez, Guillermo de Roos, Baukje TI Dietary fatty acids affecting hepatic metabolism and atherosclerosis - mechanisms unravelled using a proteomics approach SO GRASAS Y ACEITES LA English DT Review DE Atherosclerosis; Dietary fatty acids; Extra virgin olive oils; Hepatic lipid metabolism; Proteomics ID CONJUGATED LINOLEIC-ACID; EARLY AORTIC ATHEROSCLEROSIS; MEDITERRANEAN DIET; FISH CONSUMPTION; SERUM-LIPIDS; NUTRITION; LIVER; RISK; MICE; OIL AB Dietary fatty acids play an important role in the aetiology of coronary heart disease. The effects of dietary fatty acids on lipoprotein metabolism are well. described, but additional or alternative mechanisms relating to potential influence on coronary heart disease are not known. This review describes how proteomics techniques have been used to identify proteins that are differentially regulated by dietary fatty acids. Such proteins may reveal pathways by which dietary fatty acids influence disease risk. C1 [Rodriguez Gutierrez, Guillermo; de Roos, Baukje] Rowett Res Inst, Div Vasc Hlth, Aberdeen AB21 9SB, Scotland. C3 University of Aberdeen RP de Roos, B (通讯作者)，Rowett Res Inst, Div Vasc Hlth, Greenburn Rd, Aberdeen AB21 9SB, Scotland. EM b.deroos@rowett.ac.uk RI Rodríguez Gutiérrez, Guillermo/D-2533-2015 OI Rodríguez Gutiérrez, Guillermo/0000-0002-5838-1665; de Roos, Baukje/0000-0002-2750-3914 FU Scottish Government Rural and Environment Research and Analysis Directorate (RERAD); Ministerio de Educacion y Ciencia (Spain) [2007-0954] FX The authors' work is funded by the Scottish Government Rural and Environment Research and Analysis Directorate (RERAD). The authors wish to thank to Ministerio de Educacion y Ciencia (Spain) for the fellowship (2007-0954) granted to GRG. 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Olive oil is the main source of fat in the Mediterranean diet. Data accumulated thus far show consumption of extra virgin, (poly)phenol-rich olive oil to be associated with specific health benefits. Of note, recommendations for consumption based on health claims refer to the phenolic content of extra virgin olive oil as beneficial. However, even though foods rich in monounsaturated fatty acids, such as olive oil, are healthier than foods rich in saturated and trans fats, their inordinate use can lead to adverse effects on health. The aim of this review was to summarize the data on olive oil consumption worldwide and to critically examine the literature on the potential adverse effects of olive oil and its main components, particularly any effects on lipid metabolism. As demonstrated by substantial evidence, extra virgin olive oil is healthful and should be preferentially used within the context of a balanced diet, but excessive consumption may lead to adverse consequences. C1 [Tome-Carneiro, Joao; Carmen Crespo, Maria; Visioli, Francesco] Madrid Inst Adv Studies IMDEA Food, Lab Funct Foods, Campus Int Excellence UAM CSIC, Madrid, Spain. [Lopez de las Hazas, Maria Carmen; Davalos, Alberto] Madrid Inst Adv Studies IMDEA Food, Lab Epigenet Lipid Metab, Campus Int Excellence UAM CSIC, Madrid, Spain. [Visioli, Francesco] Univ Padua, Dept Mol Med, Padua, Italy. C3 Consejo Superior de Investigaciones Cientificas (CSIC); IMDEA Food Institute; IMDEA Food Institute; Consejo Superior de Investigaciones Cientificas (CSIC); University of Padua RP Dávalos, A (通讯作者)，CEI UAM CSIC, IMDEA Food Inst, Carretera Cantoblanco 8, Madrid 28049, Spain. EM alberto.davalos@imdea.org RI Visioli, Francesco/J-9356-2013; Crespo, María del Carmen/P-3925-2015; Tomé-Carneiro, João/J-6976-2014; López de las Hazas, María Carmen/L-3033-2017; Davalos, Alberto/AAA-9949-2021 OI Visioli, Francesco/0000-0002-1756-1723; Crespo, María del Carmen/0000-0003-0546-2143; Tomé-Carneiro, João/0000-0002-3597-9234; López de las Hazas, María Carmen/0000-0001-8199-6724; FU Fundacion Ramon Areces, Madrid, Spain [CIVP18A3888]; Agencia Estatal de Investigacion, Madrid, Spain; European FEDER Funds [AGL2016-78922-R]; Regione del Veneto (POR FESR 3S4H), Venice, Italy; Consejeria de Educacion, Juventud y Deporte de la Comunidad de Madrid, Fondo Social Europeo; Iniciativa de Empleo Juvenil YEI [PEJD-2016/BIO-2781] FX This research was funded by grants (CIVP18A3888) from the Fundacion Ramon Areces, Madrid, Spain, to A.D., J.T-C., F.V., and M.C.C.; by the Agencia Estatal de Investigacion, Madrid, Spain; by European FEDER Funds (AGL2016-78922-R) to A.D.; and by a grant from the Regione del Veneto (POR FESR 3S4H), Venice, Italy, to F.V. M.C.L.H. was supported by a contract from Consejeria de Educacion, Juventud y Deporte de la Comunidad de Madrid, Fondo Social Europeo, and Iniciativa de Empleo Juvenil YEI (PEJD-2016/BIO-2781). None of the funders had any role in the conception, design, performance, or approval of this work. 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Rev. PD NOV PY 2020 VL 78 IS 11 BP 952 EP 968 DI 10.1093/nutrit/nuaa014 PG 17 WC Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Nutrition & Dietetics GA OW8JA UT WOS:000593124900006 PM 32299100 DA 2026-02-02 ER PT J AU Fraser, A Abel, R Lawlor, DA Fraser, D Elhayany, A AF Fraser, A. Abel, R. Lawlor, D. A. Fraser, D. Elhayany, A. TI A modified Mediterranean diet is associated with the greatest reduction in alanine aminotransferase levels in obese type 2 diabetes patients: results of a quasi-randomised controlled trial SO DIABETOLOGIA LA English DT Article DE alanine aminotransferase; Mediterranean diet; non-alcoholic fatty liver disease; randomised controlled trial; type 2 diabetes ID FATTY LIVER-DISEASE; INSULIN-RESISTANCE; CARDIOVASCULAR RISK; FOOD FREQUENCY; WEIGHT-LOSS; WOMEN AB Aim The aim of the study was to compare the effect of different dietary interventions on alanine aminotransferase (ALT) in obese patients with diabetes. Methods A post hoc analysis of an open label, parallel design, quasi-randomised (allocation by alternation), controlled trial, conducted in Israel. Obese patients with diabetes (n=259), treated in the community, were centrally allocated to one of three diets: (1) the 2003 recommended American Diabetes Association diet (ADA): 50-55% carbohydrate, 30% fat and 20% protein, n=85; (2) a low glycaemic index (LGI) diet: 50-55% LGI carbohydrate, 30% fat, 15-20% protein, n=89; or (3) a modified Mediterranean diet (MMD): 35% LGI carbohydrate, 45% fat that was high in monounsaturated fat, 15-20% protein, n=85. ALT was measured at 6 and 12 months. Results ALT levels decreased in all arms; however, the MMD was associated with the lowest ALT levels at month 6 (n=201: ADA n=64, LGI n=73, MMD n=64) and month 12 of follow-up (n=179). At 12 months mean ALT levels were 19.8 +/- 1.4 U/l in the ADA diet arm (n=54), 18.0 +/- 1.5 U/l in the LGI diet arm (n=64) and 14.4 +/- 1.7 in the MMD arm (n=61, p < 0.001). Evidence for an effect of diet on ALT levels persisted when controlling for post-randomisation changes in waist to hip ratio, BMI, homeostasis model assessment (HOMA) or triacylglycerol. Conclusions A Mediterranean diet may have a beneficial effect on liver steatosis in obese patients with diabetes. Results of trials assessing the effect of dietary composition on clinical outcomes should be awaited before a decisive conclusion can be reached. In addition to clinical outcomes, such studies should address the issue of primary prevention of steatosis in high-risk and healthy individuals. Trial registration: ClinicalTrials.gov NCT00520182 Funding: This study was supported by a grant from Tnuva Research Institute, Rehovot, Israel. C1 [Fraser, A.; Lawlor, D. A.] Univ Bristol, Dept Social Med, Bristol BS8 2PR, Avon, England. [Abel, R.; Elhayany, A.] Clalit Hlth Serv, Rishon Leziyyon, Israel. [Fraser, D.] Ben Gurion Univ Negev, Dept Epidemiol, IL-84105 Beer Sheva, Israel. [Fraser, D.] Ben Gurion Univ Negev, S Daniel Abraham Int Ctr Hlth & Nutr, IL-84105 Beer Sheva, Israel. C3 University of Bristol; Clalit Health Services; Ben-Gurion University of the Negev; Ben-Gurion University of the Negev RP Fraser, A (通讯作者)，Univ Bristol, Dept Social Med, Canynge Hall,Whiteladies Rd, Bristol BS8 2PR, Avon, England. EM Abigail.fraser@bristol.ac.uk RI ; Fraser, Abigail/AEM-4021-2022 OI Lawlor, Debbie A/0000-0002-6793-2262; Fraser, Abigail/0000-0002-7741-9470; Bhandari, Monesh/0000-0001-9461-3948 FU Medical Research Council [G0600705] Funding Source: researchfish; MRC [G0600705] Funding Source: UKRI; Medical Research Council [G0600705] Funding Source: Medline; Department of Health Funding Source: Medline CR Albright A, 2000, MED SCI SPORT EXER, V32, P1345 [Anonymous], 2002, Gastroenterology, V123, P1702 Donnelly KL, 2005, J CLIN INVEST, V115, P1343, DOI 10.1172/JCI200523621 Esposito K, 2004, JAMA-J AM MED ASSOC, V292, P1440, DOI 10.1001/jama.292.12.1440 Estruch R, 2006, ANN INTERN MED, V145, P1, DOI 10.7326/0003-4819-145-1-200607040-00004 Franz Marion J, 2003, Diabetes Care, V26 Suppl 1, pS51 GRANT A, BRIT SOC GASTROENTER Harrison SA, 2007, GUT, V56, P1760, DOI 10.1136/gut.2006.112094 MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883 Musso G, 2003, HEPATOLOGY, V37, P909, DOI 10.1053/jhep.2003.50132 Ryan MC, 2007, DIABETES CARE, V30, P1075, DOI 10.2337/dc06-2169 Shahar D, 2003, EUR J EPIDEMIOL, V18, P855, DOI 10.1023/A:1025634020718 Shahar DR, 2007, DIABETES CARE, V30, P485, DOI 10.2337/dc06-1564 Shai I, 2005, J NUTR, V135, P573, DOI 10.1093/jn/135.3.573 Targher G, 2007, DIABETES CARE, V30, P1212, DOI 10.2337/dc06-2247 Tiikkainen M, 2003, DIABETES, V52, P701, DOI 10.2337/diabetes.52.3.701 Westerbacka J, 2004, DIABETOLOGIA, V47, P1360, DOI 10.1007/s00125-004-1460-1 Zivkovic AM, 2007, AM J CLIN NUTR, V86, P285, DOI 10.1093/ajcn/86.2.285 NR 18 TC 70 Z9 76 U1 0 U2 11 PU SPRINGER PI NEW YORK PA 233 SPRING ST, NEW YORK, NY 10013 USA SN 0012-186X J9 DIABETOLOGIA JI Diabetologia PD SEP PY 2008 VL 51 IS 9 BP 1616 EP 1622 DI 10.1007/s00125-008-1049-1 PG 7 WC Endocrinology & Metabolism WE Science Citation Index Expanded (SCI-EXPANDED) SC Endocrinology & Metabolism GA 334QL UT WOS:000258236200009 PM 18597068 OA Bronze DA 2026-02-02 ER PT J AU Lee, YY Crauste, C Wang, HL Leung, HH Vercauteren, J Galano, JM Oger, C Durand, T Wang, JMF Lee, JCY AF Lee, Yiu Yiu Crauste, Celine Wang, Hualin Leung, Ho Hang Vercauteren, Joseph Galano, Jean-Marie Oger, Camille Durand, Thierry Wang, Jennifer Man-Fan Lee, Jetty Chung-Yung TI Extra Virgin Olive Oil Reduced Polyunsaturated Fatty Acid and Cholesterol Oxidation in Rodent Liver: Is This Accounted for Hydroxytyrosol-Fatty Acid Conjugation? SO CHEMICAL RESEARCH IN TOXICOLOGY LA English DT Article ID CYCLIC OXYGENATED METABOLITES; CARBON-TETRACHLORIDE; DOCOSAHEXAENOIC ACID; LIPID-PEROXIDATION; IN-VIVO; CARDIOVASCULAR-DISEASE; MEDITERRANEAN DIET; ARACHIDONIC-ACID; GENE-EXPRESSION; CANCER CELLS AB The effects of extra virgin olive oil (EVOO) and carbon tetrachloride (CCl4) induced oxidative stress in rats were determined by the generation of isoprostanoids. These are known to be robust biomarkers to evaluate nonenzymatic and free radical related oxidation. Other oxidative stress biomarkers such as hydroxyeicosatetraenoic acid products (HETEs) and cholesterol oxidation products (COPs) were also determined. The rodents received a control diet, high-fat diet (20% w/w) composed of extra virgin olive oil (EVOO), corn oil (CO), or lard, and high-fat diets with CCl4 insult throughout the experimental period. The EVOO diet was found to suppress the formation of isoprostanoids and COPs compared to that of the control. EVOO also had a high total phenolic content and antioxidant activity compared to those of CO and lard and may be contributed to by the hydroxytyrosol component conjugated to fatty acids (HT-FA). This is the first study to identify HT-FA in EVOO, and it was 4-fold higher than that of olive oil, whereas none was found in corn oil. Furthermore, the EVOO diet showed reduced liver lipid vesicles in CCl4 treated rats compared to that of the control. However, liver toxicity measurements (aspartate transaminase) and ALT (alanine transaminase) activities showed augmentation with CCl4 treatment but were not alleviated by the diets given. Our findings suggest that EVOO is a daily functional food capable of enhancing the antioxidant system for liver protection; the effect is potentially attributed to the phenolic and lipophenolic (phenol conjugated by fatty acids) content. C1 [Lee, Yiu Yiu; Wang, Hualin; Leung, Ho Hang; Wang, Jennifer Man-Fan; Lee, Jetty Chung-Yung] Univ Hong Kong, Sch Biol Sci, Pokfulam Rd, Hong Kong, Hong Kong, Peoples R China. [Crauste, Celine; Vercauteren, Joseph; Galano, Jean-Marie; Oger, Camille; Durand, Thierry] Univ Montpellier, CNRS, UMR 5247, Inst Biomol Max Mousseron, 15 Ave Charles Flahault, F-34093 Montpellier 05, France. [Crauste, Celine; Vercauteren, Joseph; Galano, Jean-Marie; Oger, Camille; Durand, Thierry] ENSCM Sch Chem, Fac Pharm, 15 Ave Charles Flahault, F-34093 Montpellier 05, France. C3 University of Hong Kong; Centre National de la Recherche Scientifique (CNRS); Universite de Montpellier; Universite de Montpellier; Ecole nationale superieure de chimie de Montpellier RP Lee, JCY (通讯作者)，Univ Hong Kong, Sch Biol Sci, Pokfulam Rd, Hong Kong, Hong Kong, Peoples R China. EM jettylee@hku.hk RI ; Lee, Jetty Chung-Yung/E-1475-2011; Wang, Hualin/ABD-1806-2021; Vercauteren, Joseph/AAF-7151-2019; Camille, OGER/JED-5281-2023 OI Crauste, Céline/0000-0002-5714-8749; Leung, Ho Hang/0009-0008-9773-3919; Lee, Jetty Chung-Yung/0000-0002-8175-7069; Wang, Hualin/0000-0002-8129-077X; Camille, OGER/0000-0002-5177-5792 FU University of Hong Kong [201211159156, 201310159020, 201409176019] FX We thank The University of Hong Kong, Seed Funding for Basic Research (Nos. 201211159156 and 201310159020) and Small Project Funding (No. 201409176019) for the support of this work. 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Res. Toxicol. PD OCT PY 2016 VL 29 IS 10 BP 1689 EP 1698 DI 10.1021/acs.chemrestox.6b00214 PG 10 WC Chemistry, Medicinal; Chemistry, Multidisciplinary; Toxicology WE Science Citation Index Expanded (SCI-EXPANDED) SC Pharmacology & Pharmacy; Chemistry; Toxicology GA DZ3YK UT WOS:000385785600011 PM 27588434 OA Green Submitted DA 2026-02-02 ER PT J AU Ginter, E Simko, AF Ginter, E. Simko, V TI Recent data on Mediterranean diet, cardiovascular disease, cancer, diabetes and life expectancy SO BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY LA English DT Review DE mediterranean diet; cardiovascular diseases; hypertension; cancer; metabolic syndrome; diabetes; hepatic steatosis; life expectancy; oleocanthal; resveratrol; sirtuins; telomeres ID VIRGIN OLIVE OIL; RISK; METAANALYSIS; MORTALITY AB Benefits of dietary moderation when on a mediterranean diet type (MD) have been known for well over half a century. In the past, there has been a vigorous renewal of interest in preventive potential of MD. This review is unique, by focusing on the very recent confirmatory data on the MD, all published within the first half of 2014. Benefits of MD in preventing and reducing cardiovascular disorders (CVD), known before, have been strongly confirmed. While there is little doubt regarding potential benefit of MD for obesity, diabetes type II, metabolic syndrome and fatty liver, critical evaluation has to be aimed at reported benefits of MD in such widely metabolic diverse disorders as cancer, pulmonary disease and cognition defects, including Alzheimer disease (Ref. 20). Text in PDF www.elis.sk. C1 [Ginter, E.; Simko, V] Inst Prevent & Clin Med, Bratislava, Slovakia. RP Ginter, E (通讯作者)，Racianska 17, SK-83102 Bratislava, Slovakia. 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Med. J. PY 2015 VL 116 IS 6 BP 346 EP 348 DI 10.4149/BLL_2015_065 PG 3 WC Medicine, General & Internal WE Science Citation Index Expanded (SCI-EXPANDED) SC General & Internal Medicine GA CL0KM UT WOS:000356631600001 PM 26084734 OA Bronze DA 2026-02-02 ER PT J AU Bullón-Vela, V Abete, I Zulet, MA Xu, YF Martínez-González, MA Sayón-Orea, C Ruiz-Canela, M Toledo, E Sánchez, VM Estruch, R Lamuela-Raventós, RM Almanza-Aguilera, E Fitó, M Salas-Salvadó, J Díaz-López, A Tinahones, FJ Tur, JA Romaguera, D Konieczna, J Pintó, X Daimiel, L Rodriguez-Mateos, A Martínez, JA AF Bullon-Vela, Vanessa Abete, Itziar Angeles Zulet, Maria Xu, Yifan Martinez-Gonzalez, Miguel A. Sayon-Orea, Carmen Ruiz-Canela, Miguel Toledo, Estefania Martin Sanchez, Vicente Estruch, Ramon Maria Lamuela-Raventos, Rosa Almanza-Aguilera, Enrique Fito, Montserrat Salas-Salvado, Jordi Diaz-Lopez, Andres Tinahones, Francisco J. Tur, Josep A. Romaguera, Dora Konieczna, Jadwiga Pinto, Xavier Daimiel, Lidia Rodriguez-Mateos, Ana Alfredo Martinez, Jose TI Urinary Resveratrol Metabolites Output: Differential Associations with Cardiometabolic Markers and Liver Enzymes in House-Dwelling Subjects Featuring Metabolic Syndrome SO MOLECULES LA English DT Article DE antioxidant; inflammation; liver enzymes; metabolic syndrome; non-alcoholic fatty liver disease; resveratrol ID MEDITERRANEAN DIET ADHERENCE; HOMEOSTASIS MODEL ASSESSMENT; FATTY LIVER; INSULIN SENSITIVITY; RISK-FACTORS; DISEASE; BIOAVAILABILITY; HEALTH; WINE; SUPPLEMENTATION AB Metabolic syndrome (MetS) components are strongly associated with increased risk of non-alcoholic fatty liver disease (NAFLD) development. Several studies have supported that resveratrol is associated with anti-inflammatory and antioxidant effects on health status. The main objective of this study was to assess the putative associations between some urinary resveratrol phase II metabolites, cardiometabolic, and liver markers in individuals diagnosed with MetS. In this cross-sectional study, 266 participants from PREDIMED Plus study (PREvencion con DIeta MEDiterranea) were divided into tertiles of total urinary resveratrol phase II metabolites (sum of five resveratrol conjugation metabolites). Urinary resveratrol metabolites were analyzed by ultra- performance liquid chromatography coupled to triple quadrupole mass spectrometry (UPLC-Q-q-Q MS), followed by micro-solid phase extraction (mu-SPE) method. Liver function markers were assessed using serum levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), and gamma-glutamyl transferase (GGT). Moreover, lipid profile was measured by triglycerides, very-low-density lipoprotein cholesterol (VLDL-c), and total cholesterol/high-density lipoprotein ratio (total cholesterol/HDL). Linear regression adjusted models showed that participants with higher total urine resveratrol concentrations exhibited improved lipid and liver markers compared to the lowest tertile. For lipid determinations: log triglycerides (beta(T3)=-0.15, 95% CI; -0.28, -0.02,p-trend = 0.030), VLDL-c, (beta(T3)=-4.21, 95% CI; -7.97, -0.46,p-trend = 0.039), total cholesterol/HDL ratio Moreover, (beta(T3)=-0.35, 95% CI; -0.66, -0.03,p-trend = 0.241). For liver enzymes: log AST (beta(T3)=-0.12, 95% CI; -0.22, -0.02,p-trend = 0.011, and log GGT (beta(T3)=-0.24, 95% CI; -0.42, -0.06,p-trend = 0.002). However, there is no difference found on glucose variables between groups. To investigate the risk of elevated serum liver markers, flexible regression models indicated that total urine resveratrol metabolites were associated with a lower risk of higher ALT (169.2 to 1314.3 nmol/g creatinine), AST (599.9 to 893.8 nmol/g creatinine), and GGT levels (169.2 to 893.8 nmol/g creatinine). These results suggested that higher urinary concentrations of some resveratrol metabolites might be associated with better lipid profile and hepatic serum enzymes. Moreover, urinary resveratrol excreted showed a reduced odds ratio for higher liver enzymes, which are linked to NAFLD. C1 [Bullon-Vela, Vanessa; Abete, Itziar; Angeles Zulet, Maria; Alfredo Martinez, Jose] Univ Navarra, Ctr Nutr Res, Dept Nutr Food Sci & Physiol, Pamplona 31008, Spain. [Abete, Itziar; Angeles Zulet, Maria; Martinez-Gonzalez, Miguel A.; Sayon-Orea, Carmen; Ruiz-Canela, Miguel; Toledo, Estefania; Estruch, Ramon; Maria Lamuela-Raventos, Rosa; Fito, Montserrat; Salas-Salvado, Jordi; Diaz-Lopez, Andres; Tinahones, Francisco J.; Tur, Josep A.; Romaguera, Dora; Konieczna, Jadwiga; Pinto, Xavier; Alfredo Martinez, Jose] Inst Salud Carlos III ISCIII, MP Fisiopatol Obesidad & Nutr CIBERObn, Consorcio CIBER, Madrid 28029, Spain. [Xu, Yifan; Rodriguez-Mateos, Ana] Kings Coll London, Fac Life Sci & Med, Sch Life Course Sci, Dept Nutr Sci, London SE1 9NH, England. [Martinez-Gonzalez, Miguel A.; Sayon-Orea, Carmen; Ruiz-Canela, Miguel; Toledo, Estefania] Univ Navarra, Dept Prevent Med & Publ Hlth, Pamplona 31008, Spain. [Martin Sanchez, Vicente] Inst Salud Carlos III ISCIII, Ctr Invest Biomed Red Epidemiol & Salud Publ CIBE, Madrid 28029, Spain. [Martin Sanchez, Vicente] Univ Leon, Inst Biomed IBIOMED, Leon 24071, Spain. [Estruch, Ramon] Univ Barcelona, Hosp Clin, Dept Internal Med, IDIBAPS, Barcelona 08036, Spain. [Maria Lamuela-Raventos, Rosa] Univ Barcelona, Nutr & Food Safety Res Inst, Dept Nutr Food Sci & Gastron, XaRTA,INSA UB,Sch Pharm & Food Sci, Barcelona 08028, Spain. [Almanza-Aguilera, Enrique; Fito, Montserrat] Hosp del Mar Res Inst IMIM, Cardiovasc Risk & Nutr Res Grp CARIN, Barcelona 08007, Spain. [Almanza-Aguilera, Enrique] Inst Hlth Carlos III, CIBER Fragilidad & Envejecimiento Saludable CIBER, Madrid 28029, Spain. [Almanza-Aguilera, Enrique] Univ Barcelona, Inst Nutr & Food Safety INSA UB, Barcelona 08921, Spain. [Salas-Salvado, Jordi; Diaz-Lopez, Andres] Univ Rovira & Virgili, Dept Bioquim & Biotecnol, Unitat Nutr Humana, Reus 43201, Spain. [Salas-Salvado, Jordi; Diaz-Lopez, Andres] Hosp Univ St Joan de Reus, Inst Invest Pere Virgili IISPV, Reus 43204, Spain. [Tinahones, Francisco J.] Univ Malaga, Virgen de la Victoria Hosp, Inst Invest Biomed Malaga IBIMA, Dept Endocrinol, Malaga 29010, Spain. [Tur, Josep A.] Univ Balearic Isl, Res Grp Community Nutr & Oxidat Stress, Palma De Mallorca 07122, Spain. [Romaguera, Dora; Konieczna, Jadwiga] Univ Hosp Son Espases HUSE, Hlth Res Inst Balearic Isl IdISBa, Res Grp Nutr Epidemiol & Cardiovasc Physiopathol, Palma De Mallorca 07120, Spain. [Pinto, Xavier] Hosp Univ Bellvitge, Internal Med, Lipids & Vasc Risk Unit, Barcelona 08908, Spain. [Daimiel, Lidia; Alfredo Martinez, Jose] CEI UAM CSIC, Precis Nutr Program, IMDEA Food, Madrid 28049, Spain. C3 University of Navarra; University of London; King's College London; University of Navarra; CIBER - Centro de Investigacion Biomedica en Red; CIBERESP; Universidad de Leon; University of Barcelona; Hospital Clinic de Barcelona; IDIBAPS; University of Barcelona; Hospital del Mar Research Institute; Hospital del Mar; CIBER - Centro de Investigacion Biomedica en Red; CIBERFES; University of Barcelona; Universitat Rovira i Virgili; Universitat Rovira i Virgili; Institut d'Investigacio Sanitaria Pere Virgili (IISPV); Universidad de Malaga; IBIMA Plataforma BIONAND, Instituto de Investigacion Biomedica de Malaga; Universitat de les Illes Balears; Institut Investigacio Sanitaria Illes Balears (IdISBa); Hospital Universitari Son Espases; University of Barcelona; Institut d'Investigacio Biomedica de Bellvitge (IDIBELL); Bellvitge University Hospital; Consejo Superior de Investigaciones Cientificas (CSIC); IMDEA Food Institute RP Abete, I (通讯作者)，Univ Navarra, Ctr Nutr Res, Dept Nutr Food Sci & Physiol, Pamplona 31008, Spain.; Abete, I (通讯作者)，Inst Salud Carlos III ISCIII, MP Fisiopatol Obesidad & Nutr CIBERObn, Consorcio CIBER, Madrid 28029, Spain. EM mbullon@alumni.unav.es; iabetego@unav.es; mazulet@unav.es; yifan.xu@kcl.ac.uk; mamartinez@unav.es; msayon@unav.es; mcanela@unav.es; ETOLEDO@unav.es; vicente.martin@unileon.es; esacane@clinic.cat; lamuela@ub.edu; ealmanzaa@outlook.com; mfito@imim.es; jordi.salas@urv.cat; andres.diaz@urv.cat; fjtinahones@uma.es; pep.tur@uib.es; doraromaguera@yahoo.es; jadzia.konieczna@gmail.com; xpinto@bellvitgehospital.cat; lidia.daimiel@imdea.org; ana.rodriguez-mateos@kcl.ac.uk; jalfmtz@unav.es RI Bullón-Vela, Vanessa/AFR-2561-2022; Konieczna, Jadwiga/AAB-2817-2020; Estruch, Ramon/AAZ-3723-2020; Fito, Montserrat/C-1822-2012; Pintó Sala, Xavier/AGI-4297-2022; Tur, Josep/AAE-5748-2020; Tinahones, Francisco J/AAB-2882-2020; Daimiel-Ruiz, Lidia Ángeles/M-7779-2014; Sayon-Orea, Carmen/A-9828-2017; Toledo, Estefania/H-6211-2014; Abete, Itziar/H-4827-2017; Romaguera, Dora/ABE-7004-2020; Ruiz-Canela, Miguel/JYP-1794-2024; Almanza Aguilera, Enrique/AAA-2853-2020; Martin, Vicente/A-1597-2008; Xu, Yifan/ABA-7005-2021; Zulet, M Angeles/H-1317-2017; Lamuela-Raventos, Rosa M/F-3986-2016; Roiguez-Mateos, Ana/ABE-1560-2020; Salas-Salvadó, Jordi/C-7229-2017; Martinez-Gonzalez, Miguel A/AAE-7669-2019 OI Bullón-Vela, Vanessa/0000-0003-3639-821X; Pintó Sala, Xavier/0000-0002-2216-2444; Tur, Josep/0000-0002-6940-0761; Tinahones, Francisco J/0000-0001-6871-4403; Daimiel-Ruiz, Lidia Ángeles/0000-0001-9898-6629; Sayon-Orea, Carmen/0000-0002-4137-3263; Toledo, Estefania/0000-0002-6263-4434; Abete, Itziar/0000-0002-6475-5387; Ruiz-Canela, Miguel/0000-0002-7684-2787; Almanza Aguilera, Enrique/0000-0002-4805-0774; Díaz-López, Andrés/0000-0002-7500-5629; Martin, Vicente/0000-0003-0552-2804; Xu, Yifan/0000-0002-8999-2565; Zulet, M Angeles/0000-0002-3926-0892; Lamuela-Raventos, Rosa M/0000-0002-1287-4560; Roiguez-Mateos, Ana/0000-0003-3242-402X; Salas-Salvadó, Jordi/0000-0003-2700-7459; Martinez-Gonzalez, Miguel A/0000-0002-3917-9808 FU European Research Council [340918]; Instituto de Salud Carlos III (ISCIII) through the Fondo de Investigacion para la Salud (FIS) - European Regional Development Fund (coordinated FIS) [PI13/00673, PI13/00492, PI13/00272, PI13/01123, PI13/00462, PI13/00233, PI13/02184]; Recercaixa [2013ACUP00194]; ICREA under the ICREA Academia program; International Nut and Dried Fruit Council-FESNAD [201302]; Department of Health of the Government of Navarra [61/2015]; Fundacio La Marato de TV; AstraZeneca Young Investigators Award in Category of Obesity; Consejeria de Salud de la Junta de Andalucia [PI0458/2013, PS0358/2016, PI0137/2018, PROMETEO/2017/017]; Generalitat Valenciana [35/2011]; (FEDER funds) (Tur and Bouz); Fundacion Instituto de Investigacion Sanitaria Illes Balears; annual plan of the sustainable tourism tax and at 50%; Center for Nutrition Research of the University of Navarra; [PI13/00728]; [PI13/01090]; [PI13/01056]; [PI14/01722]; [PI14/00636]; [PI14/00618]; [PI14/00696]; [PI14/01206]; [PI14/01919]; [PI14/00853]; [PI14/01374]; [PI14/00972]; [PI14/00728]; [PI14/01471]; [PI16/00473]; [PI16/00662]; [PI16/01873]; [PI16/01094]; [PI16/00501]; [PI16/00533]; [PI16/00381]; [PI16/00366]; [PI16/01522]; [PI16/01120]; [PI17/00764]; [PI17/01183]; [PI17/00855]; [PI17/01347]; [PI17/00525]; [PI17/01827]; [PI17/00532]; [PI17/00215]; [PI17/01441]; [PI17/00508]; [PI17/01732]; [PI17/00926]; [PI19/00957]; [PI19/00386]; [PI19/00309]; [PI19/01032]; [PI19/00576]; [PI19/00017]; [PI19/01226]; [PI19/00781]; [PI19/01560]; [PI19/01332] FX The PREDIMED-Plus trial was supported by the European Research Council (Advanced Research grant 2014-2019; agreement #340918; granted to Martinez-Gonzalez); the o fficial Spanish institutions for funding scientific biomedical research, CIBER Fisiopatologia de la Obesidad y Nutricion (CIBERobn) and Instituto de Salud Carlos III (ISCIII) through the Fondo de Investigacion para la Salud (FIS) that is co-funded by the European Regional Development Fund (coordinated FIS projects led by Salas-Salvado and Vidal, including the following projects: PI13/00673, PI13/00492, PI13/00272, PI13/01123, PI13/00462, PI13/00233, PI13/02184, PI13/00728, PI13/01090, PI13/01056, PI14/01722, PI14/00636, PI14/00618, PI14/00696, PI14/01206, PI14/01919, PI14/00853, PI14/01374, PI14/00972, PI14/00728, PI14/01471, PI16/00473, PI16/00662, PI16/01873, PI16/01094, PI16/00501, PI16/00533, PI16/00381, PI16/00366, PI16/01522, PI16/01120, PI17/00764, PI17/01183, PI17/00855, PI17/01347, PI17/00525, PI17/01827, PI17/00532, PI17/00215, PI17/01441, PI17/00508, PI17/01732, PI17/00926, PI19/00957, PI19/00386, PI19/00309, PI19/01032, PI19/00576, PI19/00017, PI19/01226, PI19/00781, PI19/01560, PI19/01332), and the Especial Action Project "Implementacion y evaluacion de una intervencion intensiva sobre la actividad fisica Cohorte PREDIMED-Plus" (Salas-Salvado); the Recercaixa (grant number 2013ACUP00194) (Salas-Salvado). Moreover, J. Salas-Salvado, gratefully acknowledges the financial support by ICREA under the ICREA Academia program; the SEMERGEN grant; International Nut and Dried Fruit Council-FESNAD (Long-term effects of an energy-restricted Mediterranean diet on mortality and cardiovascular disease 2014-2015; No. 201302) (Martinez-Gonzalez); Department of Health of the Government of Navarra (61/2015), the Fundacio La Marato de TV (Ref. 201630.10); the AstraZeneca Young Investigators Award in Category of Obesity and T2D 2017 (Romaguera); grants from the Consejeria de Salud de la Junta de Andalucia (PI0458/2013; PS0358/2016; PI0137/2018), the PROMETEO/2017/017 grant from the Generalitat Valenciana, the SEMERGEN grant; grant of support to research groups 35/2011 (Balearic Islands Gov; FEDER funds) (Tur and Bouz). J.K. is contracted for the "FOLIUM" program within the FUTURMed project. Talent for the medicine within the future from the Fundacion Instituto de Investigacion Sanitaria Illes Balears (financed by 2017 annual plan of the sustainable tourism tax and at 50% with charge to the ESF Operational Program 2014-2020 of the Balearic Islands). V.B.-V. received a grant from the Center for Nutrition Research of the University of Navarra. 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32971870 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Ploeger, JM Manivel, JC Boatner, LN Mashek, DG AF Ploeger, Jonathan M. Manivel, Juan C. Boatner, Lauren N. Mashek, Douglas G. TI Caloric Restriction Prevents Carcinogen-Initiated Liver Tumorigenesis in Mice SO CANCER PREVENTION RESEARCH LA English DT Article ID HARVARD ALUMNI HEALTH; NF-KAPPA-B; HEPATOCELLULAR-CARCINOMA; MEDITERRANEAN DIET; HEPATIC STEATOSIS; UNITED-STATES; CANCER; DISEASE; PROGRESSION; METABOLISM AB Caloric restriction (CR) and endurance exercise elicit wide-ranging health benefits including reduced risk of select cancers. In addition, diet composition influences oncogenesis, although its interactions with exercise and CR are not well understood. Therefore, to investigate the potential interactions between diet and lifestyle interventions on liver tumorigenesis, the carcinogen diethylnitrosamine was administered to 72 male C57Bl/6 mice that were subsequently fed diets enriched with lard (CTL) or olive oil and were further stratified to voluntary wheel running (Ex) or 30% CR for 49 weeks. Although Ex and diet composition did not influence liver oncogenesis, CR prevented hepatic tumor formation. In addition, CR reduced steatosis, hepatocyte ballooning, inflammation, and immune cell infiltration, all of which are hallmarks in the progression of nonalcoholic fatty liver disease to liver tumorigenesis. RNA sequencing of nontransformed liver tissues from CR mice revealed changes in metabolic pathways and reduced inflammation, cytokine production, stellate cell activation and migration, and genes associated with liver injury and oncogenesis. These data demonstrate that CR protects against steatosis, liver inflammation, and liver injury and is a robust deterrent of carcinogen-induced hepatic oncogenesis. C1 [Ploeger, Jonathan M.] Univ Minnesota, Dept Food Sci & Nutr, Minneapolis, MN 55455 USA. [Manivel, Juan C.] Vet Adm Med Ctr, Dept Pathol & Lab Med, Minneapolis, MN USA. [Boatner, Lauren N.; Mashek, Douglas G.] Univ Minnesota, Dept Biochem Mol Biol & Biophys, Minneapolis, MN 55455 USA. [Mashek, Douglas G.] Univ Minnesota, Dept Med, Box 736 UMHC, Minneapolis, MN 55455 USA. C3 University of Minnesota System; University of Minnesota Twin Cities; US Department of Veterans Affairs; Veterans Health Administration (VHA); Minneapolis VA Health Care System; University of Minnesota System; University of Minnesota Twin Cities; University of Minnesota System; University of Minnesota Twin Cities RP Mashek, DG (通讯作者)，Univ Minnesota, Suite 6-155,321 Church St SE, Minneapolis, MN 55455 USA. EM dmashek@umn.edu RI Mashek, Douglas/ABD-6844-2021 OI Mashek, Douglas/0000-0001-7033-3386 FU University of Minnesota Healthy Foods Healthy Lives Institute grant FX This research was supported by a grant from the University of Minnesota Healthy Foods Healthy Lives Institute grant. 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Res. PD NOV PY 2017 VL 10 IS 11 BP 660 EP 670 DI 10.1158/1940-6207.CAPR-17-0174 PG 11 WC Oncology WE Science Citation Index Expanded (SCI-EXPANDED) SC Oncology GA FL5CA UT WOS:000414247500008 PM 28847977 DA 2026-02-02 ER PT J AU Lammert, C Vuppalanchi, S Green, K Blessing, N Desai, AP Stump, T Miller, NG Spence, L Wright, A AF Lammert, Craig Vuppalanchi, Siri Green, Kelsey Blessing, Nadia Desai, Archita P. Stump, Timothy Miller, Nana Gletsu Spence, Lisa Wright, Amy TI Effect of Mediterranean and Western diets on fatigue in patients with autoimmune hepatitis: Protocol for a randomized crossover diet intervention trial SO CONTEMPORARY CLINICAL TRIALS LA English DT Article DE Autoimmune hepatitis; AIH; Diet; Protocol ID PREVENTION; DISEASE AB Background: Fatigue is a debilitating symptom in patients with autoimmune hepatitis (AIH), and no effective treatment interventions are currently available. The anti-inflammatory properties of a Mediterranean diet (MD) may offer a potential non-pharmacological approach to reducing fatigue. This paper outlines the rationale, design, and protocol for a randomized crossover diet intervention trial to assess the effects of Mediterranean diet (MD) compared to a Western diet (WD) on fatigue levels in patients with AIH. Methods: In this crossover study, 48 subjects will be randomized to start either a MD or WD arm. After completing the initial arm, participants will switch to the opposite diet. The study team (including the PI and coordinator) and patients will remain blinded to the dietary intervention. The primary outcome will be the change in the fatigue component score of the PROMIS (R)-29 Profile v.2.0 survey during each dietary intervention. Secondary outcomes include changes in individual PROMIS-29 domain scores, mental and physical summary scores, circulating markers of inflammation (C-reactive protein and others), key liver serum biomarker levels (alanine aminotransferase, immunoglobulin G, total protein), stool microbiome (16S) and short-chain fatty acids, liver stiffness and steatosis, serum iron studies (ferritin, total iron binding capacity, transferrin saturation, hemoglobin), and nutritional markers such as serum vitamin D and magnesium levels. Conclusion: If the Mediterranean diet (MD) is associated with a statistically significant decrease in the fatigue component score of the PROMIS (R)-29 survey, it could serve as a promising non-pharmacological intervention to reduce fatigue in AIH patients, offering a novel approach to improve quality of life in this population. ClinicalTrials.gov ID: NCT06250309. C1 [Lammert, Craig; Vuppalanchi, Siri; Green, Kelsey; Blessing, Nadia; Desai, Archita P.] Indiana Univ, Dept Med, Bloomington, IN USA. [Stump, Timothy] Indiana Univ, Dept Biostat & Hlth Data Sci, Bloomington, IN USA. [Miller, Nana Gletsu; Spence, Lisa] Indiana Univ, Dept Appl Hlth Sci, Bloomington, IN USA. [Wright, Amy] Purdue Univ, Dept Nutr Sci, W Lafayette, IN USA. C3 Indiana University System; Indiana University Bloomington; Indiana University System; Indiana University Bloomington; Indiana University System; Indiana University Bloomington; Purdue University System; Purdue University RP Lammert, C (通讯作者)，Indiana Univ Sch Med, Div Gastroenterol & Hepatol, 702 Rotary Circle,Suite 225, Indianapolis, IN 46202 USA. EM clammert@iu.edu RI Gletsu-Miller, Nana/AAI-2082-2020; Lammert, Craig/AAI-3420-2020 FU Indiana University and Autoimmune Hepatitis Association FX Indiana University and Autoimmune Hepatitis Association: a 501 (c) (3) nonprofit organization that aims to provide support and hope to patients and families affected by autoimmune hepatitis through disease education and research opportunities. 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Trials PD JUL PY 2025 VL 154 AR 107951 DI 10.1016/j.cct.2025.107951 EA MAY 2025 PG 7 WC Medicine, Research & Experimental; Pharmacology & Pharmacy WE Science Citation Index Expanded (SCI-EXPANDED) SC Research & Experimental Medicine; Pharmacology & Pharmacy GA 3ET0Y UT WOS:001498590700001 PM 40368024 DA 2026-02-02 ER PT J AU Giacosa, A Barale, R Bavaresco, L Gatenby, P Gerbi, V Janssens, J Johnston, B Kas, K La Vecchia, C Mainguet, P Morazzoni, P Negri, E Pelucchi, C Pezzotti, M Rondanelli, M AF Giacosa, Attilio Barale, Roberto Bavaresco, Luigi Gatenby, Piers Gerbi, Vincenzo Janssens, Jaak Johnston, Belinda Kas, Koen La Vecchia, Carlo Mainguet, Paul Morazzoni, Paolo Negri, Eva Pelucchi, Claudio Pezzotti, Mario Rondanelli, Mariangela TI Cancer prevention in Europe: the Mediterranean diet as a protective choice SO EUROPEAN JOURNAL OF CANCER PREVENTION LA English DT Review DE alcohol; cancer; Mediterranean diet; polyphenols; prevention; wine ID ALCOHOL-CONSUMPTION; ALL-CAUSE; RISK; RESVERATROL; MORTALITY; WINE; METAANALYSIS; OBESITY; OVERWEIGHT; DRINKING AB In the coming years, European death rates because of cancer will further decline, but the overall number of cases will increase, mostly as a consequence of the ageing of the population. The target for cancer prevention in Europe will remain a healthy diet and control of obesity in addition to a decrease in smoking. A healthy diet model in European countries is the traditional Mediterranean diet, which is based on abundant and variable plant foods, high consumption of cereals, olive oil as the main (added) fat, low intake of (red) meat and moderate consumption of wine. The Mediterranean diet is associated with a reduced risk of cardiovascular disease and cancer. The biological mechanisms for cancer prevention associated with the Mediterranean diet have been related to the favourable effect of a balanced ratio of omega 6 and omega 3 essential fatty acids and high amounts of fibre, antioxidants and polyphenols found in fruit, vegetables, olive oil and wine. The Mediterranean diet also involves a Mediterranean way of drinking', that is, regular, moderate consumption of wine mainly with food. This pattern of drinking increases longevity, reduces the risk of cardiovascular disease and does not appreciably influence the overall risk of cancer. However, heavy alcohol drinking is associated with digestive, upper respiratory tract, liver and breast cancers; therefore, avoidance or restriction of alcohol consumption to two drinks/day in men and one drink/day in women is a global public health priority. European Journal of Cancer Prevention 22:90-95 (C) 2012 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins. European Journal of Cancer Prevention 2013, 22:90-95 C1 [Giacosa, Attilio] Policlin Monza, Dept Gastroenterol, I-20900 Monza, Italy. [Giacosa, Attilio] Univ Genoa, Dept Surg, Genoa, Italy. [Barale, Roberto] Univ Pisa, Dept Biol, Pisa, Italy. [Gerbi, Vincenzo] Univ Turin, Di Va PRA, Microbiol & Food Technol Sect, Turin, Italy. [Bavaresco, Luigi] CRA Res Ctr Viticulture, Conegliano, Italy. [La Vecchia, Carlo; Negri, Eva; Pelucchi, Claudio] Univ Milan, Mario Negri Inst Pharmacol Res, Milan, Italy. [La Vecchia, Carlo] Univ Milan, Dept Occupat Hlth, Milan, Italy. [Morazzoni, Paolo] Indena, Milan, Italy. [Pezzotti, Mario] Univ Verona, Dept Biotechnol, I-37100 Verona, Italy. [Rondanelli, Mariangela] Univ Pavia, Dept Appl Hlth Sci, I-27100 Pavia, Italy. [Rondanelli, Mariangela] ASP Azienda Serv Persona Pavia, Pavia, Italy. [Gatenby, Piers] UCL, Div Surg & Intervent Sci, Fac Med Sci, London, England. [Johnston, Belinda] Wexham Pk Hosp, Lady Sobell Gastrointestinal Unit, Slough SL2 4HL, Berks, England. [Janssens, Jaak; Mainguet, Paul] European Canc Prevent Org, Hasselt, Belgium. [Kas, Koen] InBioVeritas, Schilde, Belgium. C3 University of Genoa; University of Pisa; University of Turin; Istituto di Ricerche Farmacologiche Mario Negri IRCCS; University of Milan; University of Milan; University of Verona; University of Pavia; University of London; University College London RP Giacosa, A (通讯作者)，Policlin Monza, Dept Gastroenterol, Via Amati 111, I-20900 Monza, Italy. EM attilio.giacosa@policlinicodimonza.it RI Gerbi, Vincenzo/G-4457-2012; Rondanelli, Mariangela/AGD-6274-2022; Gatenby, Piers/C-1696-2008; La Vecchia, Carlo/Z-1710-2019; Negri, Eva/AAC-5698-2019; Pelucchi, Claudio/AGD-5279-2022 OI Gerbi, Vincenzo/0000-0001-7748-120X; Gatenby, Piers/0000-0002-1361-9940; BAVARESCO, Luigi/0000-0002-1278-6587; La Vecchia, Carlo/0000-0003-1441-897X; BARALE, Roberto/0000-0003-4161-2241; Negri, Eva/0000-0001-9712-8526; Pelucchi, Claudio/0000-0003-1425-8945 FU Associazione Italiana per la Ricerca sul Cancro (AIRC) FX The work of C. L. V., E.N. and C. P. was supported by the Associazione Italiana per la Ricerca sul Cancro (AIRC). 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J. Cancer Prev. PD JAN PY 2013 VL 22 IS 1 BP 90 EP 95 DI 10.1097/CEJ.0b013e328354d2d7 PG 6 WC Oncology WE Science Citation Index Expanded (SCI-EXPANDED) SC Oncology GA 048HL UT WOS:000311901900013 PM 22644232 OA Green Submitted DA 2026-02-02 ER PT J AU Ferramosca, A Moscatelli, N Di Giacomo, M Zara, V AF Ferramosca, A. Moscatelli, N. Di Giacomo, M. Zara, V. TI Dietary fatty acids influence sperm quality and function SO ANDROLOGY LA English DT Article DE high-fat diet; male infertility; metabolic syndrome; sperm mitochondria ID SEMEN QUALITY; MITOCHONDRIAL RESPIRATION; OXIDATIVE STRESS; MALE-INFERTILITY; LIVER-DISEASE; OLIVE OIL; HEPATIC LIPOGENESIS; MEDITERRANEAN DIET; METABOLIC SYNDROME; HUMAN SPERMATOZOA AB Recently, obesity has been linked to male infertility. In animal models the administration of a high-fat diet caused a reduction in sperm quality, by impairing gamete energy metabolism. The aim of this study was to investigate a possible effect of dietary fatty acids supplementation in the modulation of sperm energy metabolism and, in turn, in the improvement of sperm quality in rats fed a high-fat diet. Sexually mature male Sprague-Dawley rats were divided into four groups and fed for 4weeks a standard diet (control group), a high-fat diet (enriched in 35% of fat and 15% sucrose), a high-fat diet supplemented with 2.5% olive oil (a source of monounsaturated fatty acids) or a high-fat diet supplemented with 2.5% krill oil (a source of n-3 polyunsaturated fatty acids). Liver and adipose tissue weight, plasma glucose, insulin and lipid concentrations were determined. Activities of enzymes involved in sperm energetic metabolism were evaluated by spectrophotometric assays. Sperm mitochondrial respiratory efficiency was also assayed. The obtained results suggest that olive oil partially counteracts the negative effects of a high-fat diet on sperm quality, by increasing gamete motility, by reducing oxidative stress and slightly improving mitochondrial respiration efficiency. On the other hand, krill oil determines an increase in sperm concentration and motility, an increase in the activities of lactate dehydrogenase, Krebs cycle enzymes and respiratory chain complexes; a parallel increase in the cellular levels of ATP and a reduction in oxidative damage were also observed. These results suggest that dietary fatty acids are able to positively influence sperm quality and function. C1 [Ferramosca, A.; Moscatelli, N.; Di Giacomo, M.; Zara, V.] Univ Salento, Dipartimento Sci & Tecnol Biol & Ambientali, Via Prov Lecce Monteroni, I-73100 Lecce, Italy. [Ferramosca, A.; Moscatelli, N.] Ist Italiano Tecnol, Ctr Biomol Nanotechnol UNILE, Arnesano, LE, Italy. C3 University of Salento; Istituto Italiano di Tecnologia - IIT; Center for Biomolecular Nanotechnologies IIT RP Ferramosca, A (通讯作者)，Univ Salento, Dipartimento Sci & Tecnol Biol & Ambientali, Via Prov Lecce Monteroni, I-73100 Lecce, Italy. EM alessandra.ferramosca@unisalento.it RI Zara, Vincenzo/AAC-2900-2019; Ferramosca, Alessana/B-8801-2015 OI Zara, Vincenzo/0000-0001-6592-4501; Ferramosca, Alessana/0000-0002-8251-9652; Di Giacomo, Mariangela/0000-0002-2082-7836; MOSCATELLI, NATALINA/0000-0002-9291-9588 FU Fondazione Cassa di Risparmio di Puglia FX This research was financially supported by Fondazione Cassa di Risparmio di Puglia, regarding the project 'Obesita e infertilita maschile: ruolo degli acidi grassi nella modulazione del metabolismo energetico degli spermatozoi'. 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Lifshitz, Fima Alsina, Estefania Juiz, Natalia Zago, Valeria Lezon, Christian Rodriguez, Patricia N. Schreier, Laura Boyer, Patricia M. Friedman, Silvia M. TI Monounsaturated fatty acids-rich diets in hypercholesterolemic-growing rats SO INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION LA English DT Article DE Body fat distribution; bone mineral content; lipid profile; liver fat; MUFA ID CHOLESTEROL EFFLUX CAPACITY; MEDITERRANEAN DIET; OLIVE OIL; CARDIOVASCULAR-DISEASE; PHENOLIC-COMPOUNDS; BONE; INSULIN; LIVER; DIFFERENTIATION; METABOLISM AB The effects of replacing dietary saturated fat by different monounsaturated fatty acid (omega-9MUFA) sources on serum lipids, body fat and bone in growing hypercholesterolemic rats were studied. Rats received one of the six different diets: AIN-93G (control, C); extra virgin olive oil (OO) + C; high-oleic sunflower oil (HOSO) + C or atherogenic diet (AT) for 8 weeks; the remaining two groups received AT for 3 weeks and then, the saturated fat was replaced by an oil mixture of soybean oil added with OO or HOSO for 5 weeks. Rats consuming MUFA-rich diets showed the highest body fat, hepatic index and epididymal, intestinal and perirenal fat, and triglycerides. T-chol and non-HDL-chol were increased in HOSO rats but decreased in OO rats. Bone mineral content and density were higher in both OO and HOSO groups than in AT rats. This study casts caution to the generalization of the benefits of MUFA for the treatment of hypercholesterolemia. C1 [Macri, Elisa V.; Alsina, Estefania; Juiz, Natalia; Rodriguez, Patricia N.] Univ Buenos Aires, Dept Biochem, Sch Dent, Buenos Aires, DF, Argentina. [Lifshitz, Fima] Pediat Sunshine Acad Inc, Santa Barbara, CA USA. [Zago, Valeria; Schreier, Laura] Univ Buenos Aires, Fac Pharm & Biochem, Dept Clin Biochem, Lab Lipids & Lipoprot,INFIBIOC, Buenos Aires, DF, Argentina. [Lezon, Christian; Boyer, Patricia M.] Univ Buenos Aires, Dept Physiol, Buenos Aires, DF, Argentina. [Friedman, Silvia M.] Univ Buenos Aires, Dept Gen & Oral Biochem, Sch Dent, Buenos Aires, DF, Argentina. C3 University of Buenos Aires; University of Buenos Aires; University of Buenos Aires; University of Buenos Aires RP Friedman, SM (通讯作者)，Univ Buenos Aires, Dept Gen & Oral Biochem, Sch Dent, Marcelo T de Alvear 2142 12 B,C1122 AAH, Buenos Aires, DF, Argentina. EM friedman@odon.uba.ar OI Macri, Elisa Vanesa/0000-0001-8084-5676 FU University of Buenos Aires [20020100100613]; Pediatric Sunshine Academics Inc. FX The authors declare that they have no conflict of interest. The University of Buenos Aires, grant 20020100100613, supported this study. F.L. was supported by Pediatric Sunshine Academics Inc. E.A. also received support from Pediatric Sunshine Academics Inc. 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J. Food Sci. Nutr. PD JUN PY 2015 VL 66 IS 4 BP 400 EP 408 DI 10.3109/09637486.2015.1025719 PG 9 WC Food Science & Technology; Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Food Science & Technology; Nutrition & Dietetics GA CP6KV UT WOS:000359997000008 PM 25830945 DA 2026-02-02 ER PT J AU NAVARRO, MD PERIAGO, JL PITA, ML HORTELANO, P AF NAVARRO, MD PERIAGO, JL PITA, ML HORTELANO, P TI THE N-3 POLYUNSATURATED FATTY-ACID LEVELS IN RAT-TISSUE LIPIDS INCREASE IN RESPONSE TO DIETARY OLIVE OIL RELATIVE TO SUNFLOWER OIL SO LIPIDS LA English DT Article ID CORN-OIL; PLATELET PHOSPHOLIPIDS; MEDITERRANEAN DIET; PLASMA-LIPIDS; BRAIN LIPIDS; LIPOPROTEINS; LINOLENATE; RETINA; OMEGA-3-FATTY-ACIDS; ATHEROSCLEROSIS AB In the present study, changes in phospholipid compositions of Liver microsomes, erythrocyte membranes, platelets, aorta, cardiac muscle and brain of rats fed olive oil were compared with those of rats fed sunflower oil. Four groups of rats starting at weaning were fed for four weeks a basal diet containing 5 or 25% olive oil or sunflower oil. We found that oleic acid was higher and linoleic acid was lower in membrane phospholipids of olive oil fed rats compared to sunflower oil fed rats. Polyunsaturated fatty acids of the n-3 series were markedly elevated in all tissues of rats on the olive oil diets relative to those on the sunflower oil diets. The results are consistent with a lower linoleic/linolenic acid ratio induced by the olive oil diets, suggesting a positive correlation between olive oil ingestion and n-3 polyunsaturated fatty acid levels in cell and tissue lipids. The study suggests that an adequate intake of olive oil may enhance the conversion of n-3 fatty acids. C1 UNIV GRANADA,FAC PHARM,DEPT BIOCHEM & MOLEC BIOL,E-18071 GRANADA,SPAIN. 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M. Shafiqul Gupte, Sachin A. TI Loss-of-function G6PD variant moderated high-fat diet-induced obesity, adipocyte hypertrophy, and fatty liver in male rats SO JOURNAL OF BIOLOGICAL CHEMISTRY LA English DT Article ID GLUCOSE-6-PHOSPHATE-DEHYDROGENASE DEFICIENCY DECREASES; ADIPOSE-TISSUE INFLAMMATION; INSULIN-RESISTANCE; DISEASE; STIFFNESS; HEART; MSX1; SUPEROXIDE; STRESS; CELLS AB Obesity is a major risk factor for liver and cardiovascular diseases. However, obesity-driven mechanisms that contribute to the pathogenesis of multiple organ diseases are still obscure and treatment is inadequate. We hypothesized that increased, glucose-6-phosphate dehydrogenase (G6PD), the key rate- limiting enzyme in the pentose shunt, is critical in evoking metabolic reprogramming in multiple organs and is a signifi- cant contributor to the pathogenesis of liver and cardiovascular diseases. G6PD is induced by a carbohydrate-rich diet and insulin. Long-term (8 months) high-fat diet (HFD) feeding increased body weight and elicited metabolic reprogramming in visceral fat, liver, and aorta, of the wild-type rats. In addition, HFD increased inflammatory chemokines in visceral fat. Interestingly, CRISPR-edited loss-of-function Mediterranean G6PD variant (G6PDS188F) rats, which mimic human polymorphism, moderated HFD-induced weight gain and metabolic reprogramming in visceral fat, liver, and aorta. The G6PD S188F variant prevented HFD-induced CCL7 and adipocyte hypertrophy. Furthermore, the G6PD S188F variant increased Magel2 - a gene encoding circadian clock-related protein that suppresses obesity associated with Prader-Willi syndrome - and reduced HFDinduced non-alcoholic fatty liver. Additionally, the G6PD S188F variant reduced aging-induced aortic stiffening. Our fi ndings suggest G6PD is a regulator of HFD-induced obesity, adipocyte hypertrophy, and fatty liver. C1 [Viswanathan, Trisha; Gupte, Sachin A.] New York Med Coll, Dept Pharmacol, Valhalla, NY 10595 USA. SUNY Buffalo, Jacobs Sch Med & Biomed Sci, Dept Pharmacol & Toxicol, Buffalo, NY USA. [Nimmer, Erik; Bae, Yongho] SUNY Buffalo, Sch Engn & Appl Sci, Dept Biomed Engn, Buffalo, NY USA. [Rocic, Petra] SHSU Coll Osteopath Med, Dept Physiol & Pharmacol, Conroe, TX USA. [Bae, Yongho] SUNY Buffalo, Jacobs Sch Med & Biomed Sci, Dept Pathol & Anat Sci, Buffalo, NY USA. [Alam, S. M. Shafiqul] New York Med Coll, Dept Pathol Microbiol & Immunol PMI, Valhalla, NY USA. C3 New York Medical College; State University of New York (SUNY) System; University at Buffalo, SUNY; State University of New York (SUNY) System; University at Buffalo, SUNY; State University of New York (SUNY) System; University at Buffalo, SUNY; New York Medical College RP Gupte, SA (通讯作者)，New York Med Coll, Dept Pharmacol, Valhalla, NY 10595 USA. EM sachin_gupte@yahoo.com RI ; Bae, Yongho/M-8427-2015 OI Garcia, Victor/0000-0002-1849-8834; Tumenbayar, Bat-Ider/0009-0003-3236-057X; Bae, Yongho/0000-0002-1838-1652 FU NHLBI [1R56HL163168, 1R01HL163168, R01HL132574, R01HL166546] FX This study was support by NHLBI grants to S. A. G. (R01HL132574 and R01HL166546) and NHLBI grants to Y. B. (1R56HL163168 and 1R01HL163168) . 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Biol. Chem. PD JUL PY 2024 VL 300 IS 7 AR 107460 DI 10.1016/j.jbc.2024.107460 PG 14 WC Biochemistry & Molecular Biology WE Science Citation Index Expanded (SCI-EXPANDED) SC Biochemistry & Molecular Biology GA N5R8Y UT WOS:001364919000001 PM 38876306 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Milián-Sorribes, MC Martínez-Llorens, S Peñaranda, DS Jauralde, I Jover-Cerdá, M Tomás-Vidal, A AF Milian-Sorribes, Maria Consolacion Martinez-Llorens, Silvia Penaranda, David S. Jauralde, Ignacio Jover-Cerda, Miguel Tomas-Vidal, Ana TI Growth, Survival, and Intestinal Health Alterations in Mediterranean Yellowtail (Seriola dumerili) Due to Alternatives to Fishmeal and Fish Oil SO CURRENT ISSUES IN MOLECULAR BIOLOGY LA English DT Article DE fish oil; fishmeal; Seriola dumerili; yellowtail; gut histology; liver histology; microbiota ID TROUT ONCORHYNCHUS-MYKISS; BREAM SPARUS-AURATA; BASS DICENTRARCHUS-LABRAX; SOY PROTEIN-CONCENTRATE; FATTY-ACID-COMPOSITION; PACIFIC WHITE SHRIMP; ASIAN SEA-BASS; LIVER HISTOLOGY; SOYBEAN-MEAL; PARTIAL REPLACEMENT AB Fishmeal and fish oil substitution in aquafeeds might have adverse effects on fish growth and health, mainly in carnivorous species, such as Mediterranean yellowtail (Seriola dumerili). Mediterranean yellowtail shows great potential as an alternative aquaculture species due to its fast growth and high price on the market, but the need for high-quality protein and fatty acid content in its diets is limiting its production. In order to improve the sustainability of its production, this study was conducted with 360 fish of 35 g to evaluate the effects on fish growth and health. Six diets were used: one control diet without replacement, three with FM replacement (FM66, FM33, and FM0) (33%, 66%, and 100% FM replacement), and two with FO replacement (FO50 and FO0) (50% and 100% FO replacement). The substitution of FM was with vegetable (VM) (corn gluten) and animal (AM) (krill and meat meal) meals. The reductions in FM and FO of up to 33 and 0%, respectively, did not affect the growth and survival of S. dumerili at the intestinal morphology level, except for the anterior intestine regarding the lower villi length and width and the posterior intestine regarding the lower width of the lamina propria. On the other hand, the substitution of fish ingredients in the diet affects liver morphology, indicating alterations in the major diameter of hepatocytes or their nuclei. Finally, diet did not affect the gut microbiota with respect to the control, but significant differences were found in alpha and beta diversity when FO and FM microbiota were compared. A 66% FM replacement and total FO replacement would be possible without causing major alterations in the fish. C1 [Milian-Sorribes, Maria Consolacion; Martinez-Llorens, Silvia; Penaranda, David S.; Jauralde, Ignacio; Jover-Cerda, Miguel; Tomas-Vidal, Ana] Univ Politecn Valencia, Inst Anim Sci & Technol, Aquaculture & Biodivers Grp, Camino Vera S-N, Valencia 46022, Spain. C3 Universitat Politecnica de Valencia RP Martínez-Llorens, S (通讯作者)，Univ Politecn Valencia, Inst Anim Sci & Technol, Aquaculture & Biodivers Grp, Camino Vera S-N, Valencia 46022, Spain. EM mamisor@gmail.com; silmarll@dca.upv.es; dasncpea@upvnet.upv.es; igjaugar@doctor.upv.es; mjover@dca.upv.es; atomasv@dca.upv.es RI Jauralde, Ignacio/NQF-7666-2025; VIDAL, ANA/L-8254-2014; jover, miguel/L-9558-2014; Peñaranda, David Sanchez/L-3003-2014 OI Jauralde, Ignacio/0000-0002-8867-2834; Milián-Sorribes, Maria Consolación/0000-0002-8555-4939; MARTÍNEZ LLORENS, SILVIA/0000-0002-9824-3267; Peñaranda, David Sanchez/0000-0002-0861-976X FU Ministerio de Ciencia e Innovacin FX No Statement Available CR Abarike ED, 2018, FISH SHELLFISH IMMUN, V82, P229, DOI 10.1016/j.fsi.2018.08.037 Adamidou S, 2009, AQUACULTURE, V293, P263, DOI 10.1016/j.aquaculture.2009.04.045 Adjanke A., 2022, Int. J. Biol. Chem. 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PD JAN PY 2024 VL 46 IS 1 BP 753 EP 772 DI 10.3390/cimb46010049 PG 20 WC Biochemistry & Molecular Biology WE Science Citation Index Expanded (SCI-EXPANDED) SC Biochemistry & Molecular Biology GA GH5G9 UT WOS:001151785300001 PM 38248351 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Szczepanik, M Malesza, IJ Bajerska, J Chmurzynska, A Muzsik, A Bermagambetova, S Madry, E Walkowiak, J Lisowska, A AF Szczepanik, M. Malesza, I. J. Bajerska, J. Chmurzynska, A. Muzsik, A. Bermagambetova, S. Madry, E. Walkowiak, J. Lisowska, A. TI Energy-restricted Central-European diet stimulates liver microsomal function in obese postmenopausal women - a randomized nutritional trial with a comparison to energy-restricted Mediterranean diet SO EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES LA English DT Article DE Metabolic syndrome; Nutrition; Methacetin breath test; CYPIA2 ID METABOLIC SYNDROME; RECOMMENDATIONS; DISEASE; CYP1A2 AB OBJECTIVE: Obesity and metabolic syndrome are risk factors for liver diseases like non-alcoholic fatty liver disease and non-alcoholic steatohepatitis. A healthy food pattern is vital for managing these health problems, therefore, this study investigated how two calorie-restricted diets, the Central European diet (CED) and Mediterranean diet (MED), altered microsomal liver function in obese postmenopausal women with a risk of metabolic syndrome. PATIENTS AND METHODS: One-hundred-forty-four subjects were randomly assigned to the CED (n=72) or the MED (n=72) groups. A 13C-methacetin breath test was performed, before and after the intervention to assess CPDR (Cumulative Percentage Dose Recovery at 120 minutes of the test), TTP (Time to Peak - maximal momentary recovery of 13C) and Vmax (the maximum momentary 13C recovery). RESULTS: There was a statistically significant increase in TTP and Vmax in the CED group only (p=0.0159 and p=0.0498, respectively). Changes in CPDR and TTP due to intervention were significantly higher in the CED group than in the MED group (p=0.0440 and p=0.0115, respectively). CONCLUSIONS: This is the first study to document a stimulatory effect of the energy-restricted CED on liver microsomal function as compared to MED. The relatively short dietary intervention led to a significant difference in the CYP1A2 activity between groups. C1 [Szczepanik, M.; Malesza, I. J.; Walkowiak, J.] Poznan Univ Med Sci, Dept Pediat Gastroenterol & Metab Dis, Poznan, Poland. [Bajerska, J.; Chmurzynska, A.; Muzsik, A.] Poznan Univ Life Sci, Inst Human Nutr & Dietet, Poznan, Poland. [Bermagambetova, S.] West Kazakhstan Marat Ospanov Med Univ, Div Postgrad Educ & Int Cooperat, Aktobe, Kazakhstan. [Madry, E.] Poznan Univ Med Sci, Dept Physiol, Poznan, Poland. [Lisowska, A.] Poznan Univ Med Sci, Dept Clin Auxol & Pediat Nursing, Poznan, Poland. C3 Poznan University of Medical Sciences; Poznan University of Life Sciences; West Kazakhstan Marat Ospanov Medical University; Poznan University of Medical Sciences; Poznan University of Medical Sciences RP Walkowiak, J (通讯作者)，Poznan Univ Med Sci, Dept Pediat Gastroenterol & Metab Dis, Poznan, Poland. EM jarwalk@ump.edu.pl RI Muzsik-Kazimierska, Agata/GQB-4072-2022; Bermagambetova, Saule/AAZ-4616-2020 OI Muzsik-Kazimierska, Agata/0000-0002-1494-397X; Chmurzynska, Agata/0000-0002-2045-0709; Malesza, Ida Judyta/0000-0001-6740-8818; Bermagambetova, Saule/0000-0002-5018-0498; Bajerska, Joanna/0000-0002-2268-9326 FU National Science Centre [DEC-2013/09/B/NZ9/02365]; Poznan University of Medical Sciences, Poland [JW502-0101103115-07588]; Social Health Insurance Project, Republic of Kazakhstan [SHIP-2.3/CS-02] FX this study was funded in part by a National Science Centre grant number DEC-2013/09/B/NZ9/02365 (JB) and in part by Poznan University of Medical Sciences, Poland grant number (JW502-0101103115-07588). The design, analysis of results, and writing of this publication were carried out independently of any commercial entities. SB (WKMOMU) and JW (PTIMS) were supported by the Social Health Insurance Project, Republic of Kazakhstan (Contract No. SHIP-2.3/CS-02). 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Rev. Med. Pharmacol. Sci. PY 2020 VL 24 IS 21 BP 11165 EP 11171 DI 10.26355/eurrev_202011_23604 PG 7 WC Pharmacology & Pharmacy WE Science Citation Index Expanded (SCI-EXPANDED) SC Pharmacology & Pharmacy GA OU2PR UT WOS:000591376000033 PM 33215434 DA 2026-02-02 ER PT J AU Rose, L Wood, A Gill, T AF Rose, Laekin Wood, Amelia Gill, Timothy TI Gender differences in adherence and retention in Mediterranean diet interventions with a weight-loss outcome: A systematic review and meta-analysis SO OBESITY REVIEWS LA English DT Review DE adherence; gender; Mediterranean diet; meta-analysis; retention; systematic review ID RANDOMIZED CONTROLLED-TRIAL; FATTY LIVER-DISEASE; METABOLIC SYNDROME; LIFE-STYLE; BODY-WEIGHT; PHYSICAL-ACTIVITY; LOW-CARBOHYDRATE; RISK-FACTORS; CARDIOMETABOLIC RISK; HEPATIC STEATOSIS AB BackgroundThe Mediterranean diet has been shown to be effective in improving health outcomes and for weight loss. Adherence and retention in dietary interventions are critical to ensure the benefits of the exposure. No studies to date have assessed the role of gender in understanding participants who remain engaged and adhere to Mediterranean diet interventions.AimsThis study aimed to explore gender differences in recruitment, adherence, and retention for Mediterranean diet interventions and whether these were associated with differences in weight-loss outcomes.MethodsA systematic search was completed in EMBASE, Medline, Cochrane, and from inception to March 2023. A meta-analysis of studies reporting retention by gender was completed using odds ratios comparing female to male dropout numbers. A second meta-analysis was completed for adherence comparing standardized mean difference of Mediterranean diet scores stratified by gender. Newcastle Ottawa score was used to assess risk of bias.ResultsA total of 70 articles were included in the systematic review with six articles included in the adherence meta-analysis and nine in the dropout meta-analysis. No statistically significant difference was shown for adherence or retention by gender. Weight-loss outcomes were inconsistent.ConclusionsThe results of the study suggest a higher adherence and lower dropout for women although these results were not statistically significant. Future studies of Mediterranean diet interventions should include adherence, retention, and weight-loss data stratified by gender to allow further investigation of this relationship. C1 [Rose, Laekin; Wood, Amelia] Univ Sydney, Fac Med & Hlth, Sch Nursing & Midwifery, Nutr & Dietet, Camperdown, Australia. [Gill, Timothy] Univ Sydney, Charles Perkins Ctr, D17, Camperdown, NSW 2006, Australia. C3 University of Sydney; University of Sydney RP Gill, T (通讯作者)，Univ Sydney, Charles Perkins Ctr, D17, Camperdown, NSW 2006, Australia. 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Rev. PD DEC PY 2024 VL 25 IS 12 DI 10.1111/obr.13824 EA SEP 2024 PG 13 WC Endocrinology & Metabolism WE Science Citation Index Expanded (SCI-EXPANDED) SC Endocrinology & Metabolism GA L9F3A UT WOS:001303614200001 PM 39228092 OA hybrid DA 2026-02-02 ER PT J AU Hernandez, AV Marti, KM Marti, KE Weisman, N Cardona, M Biello, DM Jr Pasupuleti, V Benites-Zapata, VA Roman, YM Piscoya, A AF Hernandez, Adrian V. Marti, Katherine M. Marti, Kristen E. Weisman, Nissen Cardona, Michelle Biello Jr, Domenic M. Pasupuleti, Vinay Benites-Zapata, Vicente A. Roman, Yuani M. Piscoya, Alejandro TI Effect of Mediterranean Diets on Cardiovascular Risk Factors and Disease in Overweight and Obese Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials SO JOURNAL OF THE AMERICAN NUTRITION ASSOCIATION LA English DT Review DE Mediterranean diet; cardiovascular risk factor; primary prevention; obesity; meta-analysis ID WEIGHT-LOSS; LOW-FAT; LOW-CARBOHYDRATE; LIVER-DISEASE; BODY-WEIGHT; LIFE-STYLE AB We systematically evaluated effects of Mediterranean diets (MED) on cardiovascular (CV) disease and risk factors in overweight or obese adults. Five engines and two registries were searched until October 2023 for randomized controlled trials (RCTs) evaluating any type of MED compared to other diets or advice in adults. Outcomes of interest were clinical outcomes and CV risk factors (anthropometric, lipids, blood pressure, glucose metabolism, liver function). Inverse variance random effects models were used for meta-analyses; effects of MED were described as mean differences (MDs) and their 95% confidence intervals (CIs). Quality of evidence (QoE) per outcome was evaluated using GRADE methodology. Twenty-six RCTs (n = 10,352) were included. Four RCTs evaluated only obese patients and 22 evaluated overweight and obese patients. Clinical outcomes were only described in the revised 2018 PREDIMED trial where MED was associated with 35% lower risk of myocardial infarction, stroke, or CV death vs advice (hazard ratio, 0.65; 95% CI, 0.50-0.85). MED significantly reduced the values of body mass index (MD, -0.61 kg/m2; 95% CI, -1.14 to -0.09; 17 RCTs), waist circumference (MD, -2.48 cm; 95% CI, -3.99 to -0.96; 17 RCTs), triglycerides (MD, -7.93 mg/dL; 95% CI, -13.48 to -2.39; 19 RCTs), and fatty liver index (MD, -12.26; 95% CI, -23.96 to -0.56; 3 RCTs) compared with controls. MED did not significantly change any other CV risk factors. QoE was very low for most of the outcomes; 85% of RCTs had some concerns or high risk of bias. In overweight or obese adults, MED significantly decreased body mass index, waist circumference, triglycerides, and fatty liver index score but no other CV risk factors when compared with other diets or advice. There was paucity of data on effects of MED on clinical outcomes. C1 [Hernandez, Adrian V.; Marti, Katherine M.; Marti, Kristen E.; Weisman, Nissen; Cardona, Michelle; Biello Jr, Domenic M.; Roman, Yuani M.] Univ Connecticut, Sch Pharm, Hlth Outcomes Policy & Evidence Synth HOPES Grp, 69 N Eagleville Rd U-3092, Storrs, CT 06269 USA. [Hernandez, Adrian V.] Univ San Ignacio Loyola USIL, Unidad Revis Sistemat & Meta Anal URSIGET, Lima, Peru. [Pasupuleti, Vinay] Oxford PharmaGenesis Inc, Newtown, PA USA. [Benites-Zapata, Vicente A.] Univ San Ignacio Loyola, Unidad Invest Generac & Sintesis Evidencias Salud, Vicerrectorado Invest, Lima, Peru. [Piscoya, Alejandro] Hosp Guillermo Kaelin Fuente, Lima, Peru. C3 University of Connecticut; Universidad San Ignacio de Loyola; Universidad San Ignacio de Loyola RP Hernandez, AV (通讯作者)，Univ Connecticut, Sch Pharm, Hlth Outcomes Policy & Evidence Synth HOPES Grp, 69 N Eagleville Rd U-3092, Storrs, CT 06269 USA. EM adrian.hernandez-diaz@uconn.edu RI ; Piscoya, Alejano/C-6380-2012; Benites Zapata, Vicente Aleixane/AAO-9365-2020 OI Hernandez, Aian V/0000-0002-9999-4003; pasupuleti, vinay/0000-0002-5964-9520; Piscoya, Alejano/0000-0002-4420-2419; Weisman, Nissen/0009-0003-0386-543X; Benites Zapata, Vicente Aleixane/0000-0002-9158-1108; , Domenic Michael Biello/0009-0003-2177-2907 CR Abenavoli L, 2017, NUTRIENTS, V9, DOI 10.3390/nu9080870 American Heart Association, WHAT IS MEDITERRANEA Marin-Alejandre BA, 2019, NUTRIENTS, V11, DOI 10.3390/nu11102543 Austel A, 2015, EUR J CLIN NUTR, V69, P878, DOI 10.1038/ejcn.2015.11 Barnard ND, 2022, J AM NUTR ASSOC, V41, P127, DOI 10.1080/07315724.2020.1869625 Bos MB, 2010, NUTR METAB CARDIOVAS, V20, P591, DOI 10.1016/j.numecd.2009.05.008 Bouloukaki I, 2023, LIFE-BASEL, V13, DOI 10.3390/life13081755 Buscemi S, 2009, EUR J CLIN INVEST, V39, P339, DOI 10.1111/j.1365-2362.2009.02091.x Estruch R, 2018, NEW ENGL J MED, V378, DOI [10.1056/NEJMoa1200303, 10.1056/NEJMoa1800389, 10.1056/nejmoa1800389] Franquesa M, 2019, NUTRIENTS, V11, DOI 10.3390/nu11030655 Gepner Y, 2018, CIRCULATION, V137, P1143, DOI 10.1161/CIRCULATIONAHA.117.030501 Igudesman D, 2023, DIABETES OBES METAB, V25, P688, DOI 10.1111/dom.14911 Jaacks LM, 2018, BMC NUTR, V4, DOI 10.1186/s40795-018-0234-y Katsagoni CN, 2018, BRIT J NUTR, V120, P164, DOI [10.1017/S000711451800137X, 10.1017/s000711451800137x] Lacatusu CM, 2019, INT J ENV RES PUB HE, V16, DOI 10.3390/ijerph16060942 Luo YG, 2022, J CLIN ENDOCR METAB, V107, P2216, DOI 10.1210/clinem/dgac303 McManus K, 2001, INT J OBESITY, V25, P1503, DOI 10.1038/sj.ijo.0801796 Mei SS, 2022, FRONT NUTR, V9, DOI 10.3389/fnut.2022.876620 Monsalves-Alvarez M, 2023, FRONT NUTR, V10, DOI 10.3389/fnut.2023.1181436 Montemayor S, 2022, NUTRIENTS, V14, DOI 10.3390/nu14112223 Nakashima M, 2023, NUTRIENTS, V15, DOI 10.3390/nu15030748 Page Matthew J, 2021, Int J Surg, V88, P105906, DOI 10.1016/j.ijsu.2021.105906 Pavic E, 2019, INT J VITAM NUTR RES, V89, P132, DOI 10.1024/0300-9831/a000462 Rees K, 2019, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD009825.pub3 Ristic-Medic D, 2021, NUTRIENTS, V13, DOI 10.3390/nu13010015 Ryan MC, 2013, J HEPATOL, V59, P138, DOI 10.1016/j.jhep.2013.02.012 Shai I, 2008, NEW ENGL J MED, V359, P229, DOI 10.1056/NEJMoa0708681 Sofi F, 2018, CIRCULATION, V137, P1103, DOI 10.1161/CIRCULATIONAHA.117.030088 Sterne J. A. C., 2019, BMJ, V366, DOI [10.1136/bmj.l4898, DOI 10.1136/BMJ.L4898] Tsaban G, 2021, HEART, V107, P1054, DOI 10.1136/heartjnl-2020-317802 Turner-McGrievy GM, 2023, J NUTR, V153, P579, DOI 10.1016/j.tjnut.2022.11.020 Tussing-Humphreys L, 2022, PREV MED REP, V29, DOI 10.1016/j.pmedr.2022.101955 Wade AT, 2019, BRIT J NUTR, V122, P873, DOI 10.1017/S0007114519001168 World Health Organization, GLOBAL HLTH OBSERVAT NR 34 TC 8 Z9 8 U1 2 U2 5 PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD PI ABINGDON PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND SN 2769-7061 EI 2769-707X J9 J AM NUTR ASSOC JI J. Am. Nutr. Assoc. PD JUL 4 PY 2025 VL 44 IS 5 BP 387 EP 404 DI 10.1080/27697061.2024.2440051 EA DEC 2024 PG 18 WC Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Nutrition & Dietetics GA 3OP7P UT WOS:001392824600001 PM 39783962 DA 2026-02-02 ER PT J AU Amoussou, N Marengo, M Afé, OHI Lejeune, P Durieux, ÉDH Douny, C Scippo, ML Gobert, S AF Amoussou, Nellya Marengo, Michel Afe, Ogouyom Herbert Iko Lejeune, Pierre Durieux, Eric Dominique Henri Douny, Caroline Scippo, Marie-Louise Gobert, Sylvie TI Comparison of fatty acid profiles of two cultivated and wild marine fish from Mediterranean Sea SO AQUACULTURE INTERNATIONAL LA English DT Article DE Fish; Wild; Cultivated; n-3 and n-6; Health councils; Human health ID BASS DICENTRARCHUS-LABRAX; BREAM SPARUS-AURATA; TROUT ONCORHYNCHUS-MYKISS; GILTHEAD SEABREAM; RAINBOW-TROUT; NUTRITION; GROWTH; LIVER; DIETS; OIL AB Health councils recommend a higher consumption of aquatic resources because of the health benefits associated with these kinds of food. Due to its nutritional quality, fish derived from marine environment is one of the major contributors to a healthy human nutrition. This study aims to assess the fatty acid profile and nutritional composition of cultivated and wild sea bass (Dicentrarchus labrax) and sea bream (Sparus aurata) from Corsica (Mediterranean region). In both marine species, fatty acid composition showed that total polyunsaturated fatty acids were higher in cultivated fish than in wild fish. Saturated fatty acids were higher in wild fish, which had also a higher level of monounsaturated fatty acids. Regardless of species and origin, the predominant fatty acids were palmitic acid in saturated fatty acids and oleic acid in monounsaturated fatty acids. The polyunsaturated fatty acids in cultivated fish were mainly represented by linoleic acid, followed by eicosapentaenoic and docosahexaenoic acids. The n-3/n-6 ratio in cultivated fish is in accordance with the recommended range for a healthy human diet. Based on the nutritional contribution in terms of eicosapentaenoic and docosahexaenoic acids levels, this study pointed out that sea bass and sea bream cultivated in Corsica are seafood with good nutritional qualities for human health. C1 [Amoussou, Nellya; Marengo, Michel; Gobert, Sylvie] Univ Liege, Lab Oceanol, Ctr MARE, B6c, B-4000 Liege, Belgium. [Amoussou, Nellya] Univ Lorraine, Fac Sci & Technol Domaine Sci Victor Grignard, Equipe Domesticat Aquaculture Continentale, Unite Rech Anim & Fonctionnalites Prod Anim URAFP, BP 70239, F-54506 Vandoeuvre Les Nancy, France. [Marengo, Michel; Lejeune, Pierre; Gobert, Sylvie] STn REch Marines & Oceanog STARESO, F-20260 Calvi, France. [Afe, Ogouyom Herbert Iko; Douny, Caroline; Scippo, Marie-Louise] Univ Liege, Fac Med Vet, Lab Anal Denrees Alimentaires, Ave Cureghem 10,Bat B43B, B-4000 Liege, Belgium. [Afe, Ogouyom Herbert Iko] Univ dAbomey Calavi, Fac Sci Agron, Lab Sci Aliments, Ecole Nutr & Sci & Technol Alimentaires, 03,POB 2819, Jericho Cotonou, Benin. [Durieux, Eric Dominique Henri] Univ Corse Pascal Paoli, UMR 6134, CNRS UCPP Sci Environm, F-20250 Corsica, France. [Durieux, Eric Dominique Henri] Univ Corse Pascal Paoli, UCPP Plateforme Marine Stella Mare, UMS 3514, CNRS, F-20620 Biguglia, France. C3 University of Liege; Universite de Lorraine; University of Liege; University of Abomey Calavi; Centre National de la Recherche Scientifique (CNRS); CNRS - Institute for Engineering & Systems Sciences (INSIS); Centre National de la Recherche Scientifique (CNRS) RP Amoussou, N (通讯作者)，Univ Liege, Lab Oceanol, Ctr MARE, B6c, B-4000 Liege, Belgium.; Amoussou, N (通讯作者)，Univ Lorraine, Fac Sci & Technol Domaine Sci Victor Grignard, Equipe Domesticat Aquaculture Continentale, Unite Rech Anim & Fonctionnalites Prod Anim URAFP, BP 70239, F-54506 Vandoeuvre Les Nancy, France. EM nellya-lydie-yabo.amoussou@univ-lorraine.fr RI DURIEUX, Eric DH/K-1300-2012 OI DURIEUX, Eric DH/0000-0003-3074-9410 FU Agence de l'eau Rhone Mediterranee Corse; "Collectivite de Corse" (CdC), STARECAPMED project research FX This research was supported by a grant from the "Agence de l'eau Rhone Mediterranee Corse" and the "Collectivite de Corse" (CdC), as part of STARECAPMED project research. 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PD JUN PY 2022 VL 30 IS 3 BP 1435 EP 1452 DI 10.1007/s10499-022-00861-3 EA MAR 2022 PG 18 WC Fisheries WE Science Citation Index Expanded (SCI-EXPANDED) SC Fisheries GA 2B5JE UT WOS:000765646600001 OA Green Submitted DA 2026-02-02 ER PT J AU Di Palo, DM Garruti, G Di Ciaula, A Molina-Molina, E Shanmugam, H De Angelis, M Portincasa, P AF Di Palo, Domenica Maria Garruti, Gabriella Di Ciaula, Agostino Molina-Molina, Emilio Shanmugam, Harshitha De Angelis, Maria Portincasa, Piero TI Increased Colonic Permeability and Lifestyles as Contributing Factors to Obesity and Liver Steatosis SO NUTRIENTS LA English DT Article DE body mass index; intestinal permeability; obesity; sugars; urinary recovery ID INCREASED INTESTINAL PERMEABILITY; FATTY LIVER; METABOLIC SYNDROME; BACTERIAL OVERGROWTH; NONALCOHOLIC STEATOHEPATITIS; NONINVASIVE ASSESSMENT; CARDIOMETABOLIC RISK; MEDITERRANEAN DIET; GUT MICROBIOTA; HEPATIC-INJURY AB Intestinal permeability (IP) is essential in maintaining gut-metabolic functions in health. An unequivocal evaluation of IP, as marker of intestinal barrier integrity, however, is missing in health and in several diseases. We aimed to assess IP in the whole gastrointestinal tract according to body mass index (BMI) and liver steatosis. In 120 patients (61F:59M; mean age 45 +/- SEM 1.2 years, range: 18-75), IP was distinctively studied by urine recovery of orally administered sucrose (SO, stomach), lactulose/mannitol ratio (LA/MA, small intestine), and sucralose (SA, colon). By triple quadrupole mass-spectrometry and high-performance liquid chromatography, we measured urinary recovery of saccharide probes. Subjects were stratified according to BMI as normal weight, overweight, and obesity, and answered questionnaires regarding dietary habits and adherence to the Mediterranean Diet. Liver steatosis was assessed by ultrasonography. IP at every gastrointestinal tract was similar in both sexes and decreased with age. Stomach and small intestinal permeability did not differ according to BMI. Colonic permeability increased with BMI, waist, neck, and hip circumferences and was significantly higher in obese than in lean subjects. As determined by logistic regression, the odds ratio (OR) of BMI increment was significantly higher in subjects in the highest tertile of sucralose excretion, also after adjusting for age and consumption of junk food. The presence of liver steatosis was associated with increased colonic permeability. Patients with lower score of adherence to Mediterranean diet had a higher score of 'junk food'. Intestinal permeability tended to increase in subjects with a lower adherence to Mediterranean diet. In conclusion, colonic (but not stomach and small intestinal) permeability seems to be linked to obesity and liver steatosis independently from dietary habits, age, and physical activity. The exact role of these last factors, however, requires specific studies focusing on intestinal permeability. Results should pave the way to both primary prevention measures and new therapeutic strategies in metabolic and liver diseases. C1 [Di Palo, Domenica Maria; Di Ciaula, Agostino; Molina-Molina, Emilio; Shanmugam, Harshitha; Portincasa, Piero] Univ Bari Aldo Moro, Dept Biomed Sci & Human Oncol, Clin Med A Murri, I-70124 Bari, Italy. [Di Palo, Domenica Maria; De Angelis, Maria] Univ Bari Aldo Moro, Dept Soil Plant & Food Sci, I-70124 Bari, Italy. [Garruti, Gabriella] Univ Bari Aldo Moro, Med Sch, Dept Emergency & Organ Transplantat, Sect Endocrinol, I-70124 Bari, Italy. C3 Universita degli Studi di Bari Aldo Moro; Universita degli Studi di Bari Aldo Moro; Universita degli Studi di Bari Aldo Moro RP Portincasa, P (通讯作者)，Univ Bari Aldo Moro, Dept Biomed Sci & Human Oncol, Clin Med A Murri, I-70124 Bari, Italy. EM domenicamariadipalo@gmail.com; gabriella.garruti@uniba.it; agostinodiciaula@tiscali.it; emilio.molinamolina@uniba.it; harshitha.shanmugam@uniba.it; maria.deangelis@uniba.it; piero.portincasa@uniba.it RI De Angelis, Maria/AAA-9909-2019; Shanmugam, Harshitha/LCE-0958-2024; Di Ciaula, Agostino/AAW-3499-2021; portincasa, piero/J-7245-2018 OI De Angelis, Maria/0000-0002-2010-884X; Molina Molina, Emilio/0000-0003-4390-5275; Garruti, Gabriella/0000-0001-7875-7239; Shanmugam, Harshitha/0000-0002-3711-2175; Di Ciaula, Agostino/0000-0002-5476-7376; portincasa, piero/0000-0001-5359-1471 FU European Union's Horizon 2020 Research and Innovation framework, under the Marie Sklodowska-Curie Grant [722619] FX The present paper originates in the context of the project FOIE GRAS, which has received funding from the European Union's Horizon 2020 Research and Innovation framework, under the Marie Sklodowska-Curie Grant Agreement (#722619, recipients E.M.-M. and H.S.). 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Mediterranean diet; biomarkers; score; cardiovascular risk; visceral adiposity ID METABOLIC SYNDROME; ALCOHOL; OBESITY; HYPERTENSION; METAANALYSIS; DEFINITION; FREQUENCY; STATEMENT; DISEASE; CANCER AB Adherence to the Mediterranean diet (MedDiet) leads to reduction of mortality from all causes, especially in subjects with cardiovascular disease, obesity, and diabetes. Numerous scores have been proposed to evaluate the adherence to MedDiet, mainly focused on eating habits. In this study, we verified whether existing validated MedDiet scores, namely, MEDI-LITE and the Mediterranean Diet Score (MDS), could be associated with visceral adiposity. Failing to find a significant association with adiposity, we proposed the validation of a new, easy-to-use adherence questionnaire, the Chrono Med-Diet score (CMDS). CMDS contains eleven food categories, including chronobiology of dietary habits and physical activity. Compared to the MEDI-LITE score and MDS, low values of CMDS are linked to increased waist circumference (WC) and dysmetabolic conditions. CMDS was also inversely correlated with cardiovascular risk (CVR), as well as Fatty Liver Index (FLI). In conclusion, the CMDS is a novel questionnaire to study the adherence to the MedDiet that, focusing on type and timing of carbohydrates intake, has the peculiar capability of capturing subjects with abdominal obesity, thus being an easy-to-use instrument of personalized medicine. C1 [De Matteis, Carlo; Crudele, Lucilla; Battaglia, Stefano; Loconte, Tiziana; Rotondo, Arianna; Ferrulli, Roberta; Gadaleta, Raffaella Maria; Piazzolla, Giuseppina; Suppressa, Patrizia; Sabba, Carlo; Cariello, Marica; Moschetta, Antonio] Univ Bari Aldo Moro, Dept Interdisciplinary Med, I-70124 Bari, Italy. C3 Universita degli Studi di Bari Aldo Moro RP Cariello, M; Moschetta, A (通讯作者)，Univ Bari Aldo Moro, Dept Interdisciplinary Med, I-70124 Bari, Italy. EM carlo.dematteis@uniba.it; lucilla.crudele@uniba.it; battagliastefano87@gmail.com; locontenutrizionista@gmail.com; ariannarotondo90@gmail.com; ferrulliroberta@libero.it; raffaella.gadaleta@uniba.it; giuseppina.piazzolla@uniba.it; patrizia.suppressa@uniba.it; carlo.sabba@uniba.it; maricacariello@gmail.com; antonio.moschetta@gmail.com RI Suppressa, Patrizia/ORK-2346-2025; Moschetta, Antonio/K-6211-2016; Crudele, Lucilla/AAO-8817-2021; Cariello, Marica/K-4064-2018; De Matteis, Carlo/LSJ-0110-2024; Piazzolla, Giuseppina/JEO-7179-2023 OI Moschetta, Antonio/0000-0003-2123-6074; Crudele, Lucilla/0000-0002-0541-6211; De Matteis, Carlo/0000-0001-6628-2184; Piazzolla, Giuseppina/0000-0003-3221-6562 FU EU-JPI HDL-INTIMIC-MIUR FATMAL; MIUR-PON "R&I"2014-2020"BIOMIS" cod [ARS01_01220]; POR Puglia FESR-FSE 2014-2020 [4TCJLV4]; National Recovery and Resilience Plan (NRRP); Italian Ministry of University; European Union-Next Generation EU [PE00000003, CUP D93C22000890001]; Italian Ministry of University and Research [PE0000015, CUPH33C22000680006]; National Recovery and Resilience Plan (NRRP), Mission 4 Component 2 Investment FX A.M. is funded by EU-JPI HDL-INTIMIC-MIUR FATMAL; MIUR-PON "R&I" 2014-2020 "BIOMIS" cod. ARS01_01220; POR Puglia FESR-FSE 2014-2020, "INNOMA" cod. 4TCJLV4; National Recovery and Resilience Plan (NRRP), Mission 4 Component 2 Investment 1.3-Call for tender No. 341 of 15 March 2022 of Italian Ministry of University and Research funded by the European Union-NextGeneration EU. A.M. and P.S. are funded by Award Number: Project code PE00000003, Concession Decree No. 1550 of 11 October 2022 adopted by the Italian Ministry of University and Research, CUP D93C22000890001, Project title "ON Foods-Research and innovation network on food and nutrition Sustainability, Safety and Security-Working ON Foods". L.C. is funded under the National Recovery and Resilience Plan (NRRP), Mission 4 Component 2 Investment 1.3-Call for tender No. 341 of 15 March 2022 of Italian Ministry of University and Research funded by the European Union-NextGeneration EU; Award Number: Project code PE0000015, Concession Decree No. 1243 of 2 August 2022 adopted by the Italian Ministry of University and Research, CUP H33C22000680006, Project title "Ageing well in an ageing society-A novel public-private alliance to generate socioeconomic, biomedical and technological solutions for an inclusive Italian ageing society- AGE-IT". 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We investigated whether the short term nutritional effect of a fat quota mainly derived from olive and fish oil affects liver mRNA expression profile in rats. Methods and results: The study was carried out using DNA microarray techniques. The effect was evaluated at liver mRNA expression level. to identify genes whose expression was regulated by dietary modifications. Two groups of six rats were alternatively supplied for two weeks with either a control or with an experimental diet. Both diets were semisynthetic and isocaloric, with identical major nutrients composition (protein 20%, carbohydrates 56% and lipids 22% of total energy) being different only in the quality of fats. The lipid quota of the control diet contained exclusively saturated animal fats, derived from butter, while in the experimental diet some unsaturated fats were present, being derived also from olive and fish oil (10% and 6% of total energy, respectively). Out of 26,334 genes analyzed, 11,292 were found expressed in the liver, 72 were induced and 180 were inhibited from the experimental diet. Out of these, 33 of the induced and 59 of the inhibited species have a well known function. Conclusions: The diet with olive and fish oil modulates several genes related to lipolysis or lipogenesis and newly identified responders from other metabolisms. Some of these genes are also reported to be similarly modulated by the action of fibrates, but without the complete gene activation typical of these PPAR alpha ligands. (c) 2005 Elsevier Ltd. All rights reserved. C1 Univ Salerno, Dipartimento Sci Farmaceut, I-84084 Fisciano, Italy. C3 University of Salerno RP Tecce, MF (通讯作者)，Univ Salerno, Dipartimento Sci Farmaceut, Via Ponte Don Melillo, I-84084 Fisciano, Italy. 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Metab. Carbiovasc. Dis. PD FEB PY 2005 VL 15 IS 1 BP 13 EP 23 DI 10.1016/j.numecd.2004.07.001 PG 11 WC Cardiac & Cardiovascular Systems; Endocrinology & Metabolism; Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Cardiovascular System & Cardiology; Endocrinology & Metabolism; Nutrition & Dietetics GA 923IG UT WOS:000228903000004 PM 15871846 DA 2026-02-02 ER PT J AU Martinez, JE Kahana, DD Ghuman, S Wilson, HP Wilson, J Kim, SCJ Lagishetty, V Jacobs, JP Sinha-Hikim, AP Friedman, TC AF Martinez, Jason E. Kahana, Doron D. Ghuman, Simran Wilson, Haley P. Wilson, Julian Kim, Samuel C. J. Lagishetty, Venu Jacobs, Jonathan P. Sinha-Hikim, Amiya P. Friedman, Theodore C. TI Unhealthy Lifestyle and Gut Dysbiosis: A Better Understanding of the Effects of Poor Diet and Nicotine on the Intestinal Microbiome SO FRONTIERS IN ENDOCRINOLOGY LA English DT Review DE gut microbiome; gut microbiota; gut dysbiosis; nicotine; obesity; high-fat diet; nonalcoholic fatty liver disease; e-cigarette ID HIGH-FAT DIET; GLUTEN-FREE DIET; INFLAMMATORY-BOWEL-DISEASE; CENTRAL-NERVOUS-SYSTEM; HEPATIC STEATOSIS; OXIDATIVE STRESS; CARDIORESPIRATORY FITNESS; MEDITERRANEAN DIET; CIGARETTE-SMOKING; ALPHA-SYNUCLEIN AB The study of the intestinal or gut microbiome is a newer field that is rapidly gaining attention. Bidirectional communication between gut microbes and the host can impact numerous biological systems regulating immunity and metabolism to either promote or negatively impact the host's health. Habitual routines, dietary choices, socioeconomic status, education, host genetics, medical care and environmental factors can all contribute to the composition of an individual's microbiome. A key environmental factor that may cause negative outcomes is the consumption of nicotine products. The effects of nicotine on the host can be exacerbated by poor dietary choices and together can impact the composition of the gut microbiota to promote the development of metabolic disease including non-alcoholic fatty liver disease. This review explores the contribution of nicotine, poor dietary choices and other unhealthy lifestyle factors to gut dysbiosis. C1 [Martinez, Jason E.; Kahana, Doron D.; Ghuman, Simran; Wilson, Haley P.; Wilson, Julian; Kim, Samuel C. J.; Sinha-Hikim, Amiya P.; Friedman, Theodore C.] Charles R Drew Univ Med & Sci, Dept Internal Med, 1621 E 120th St, Los Angeles, CA 90059 USA. [Kahana, Doron D.; Sinha-Hikim, Amiya P.; Friedman, Theodore C.] Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Los Angeles, CA 90095 USA. [Lagishetty, Venu; Jacobs, Jonathan P.] Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Vatche & Tamar Manoukian,Div Digest Dis, Los Angeles, CA 90095 USA. [Lagishetty, Venu; Jacobs, Jonathan P.] Univ Calif Los Angeles, David Geffen Sch Med, UCLA Microbiome Ctr, Los Angeles, CA 90095 USA. [Jacobs, Jonathan P.] Vet Adm Greater Los Angeles Healthcare Syst, Div Gastroenterol Hepatol & Parenteral Nutr, Los Angeles, CA USA. C3 Charles R. Drew University of Medicine & Science; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; US Department of Veterans Affairs; Veterans Health Administration (VHA); VA Greater Los Angeles Healthcare System RP Friedman, TC (通讯作者)，Charles R Drew Univ Med & Sci, Dept Internal Med, 1621 E 120th St, Los Angeles, CA 90059 USA.; Friedman, TC (通讯作者)，Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Los Angeles, CA 90095 USA. EM theodorefriedman@cdrewu.edu RI Lagishetty, Venu/C-8251-2009; Jaco, Jonathan/AEA-2052-2022; Wilson, Haley/GZM-2799-2022 OI Jaco, Jonathan/0000-0003-4698-0254; Wilson, Julian/0000-0002-8883-6843 FU NIH [MD012579-01, R25 DA050723, U54 MD007598]; DOD CDMRP grant [PR190942]; VA [CDA2 IK2CX001717]; California Tobacco-Related Disease Research Program (TRDRP) Community Practice-Based Research Implementation Award [28CP-0040]; National Institute on Drug Abuse [R25DA050723] Funding Source: NIH RePORTER; National Institute on Drug Abuse; National Institute on Minority Health and Health Disparities [U54MD007598] Funding Source: NIH RePORTER FX Funded by NIH grants MD012579-01, R25 DA050723, U54 MD007598, DOD CDMRP grant PR190942, VA CDA2 IK2CX001717, and California Tobacco-Related Disease Research Program (TRDRP) Community Practice-Based Research Implementation Award 28CP-0040. 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PD JUN 8 PY 2021 VL 12 AR 667066 DI 10.3389/fendo.2021.667066 PG 13 WC Endocrinology & Metabolism WE Science Citation Index Expanded (SCI-EXPANDED) SC Endocrinology & Metabolism GA SW1AZ UT WOS:000664249900001 PM 34168615 OA Green Submitted, gold DA 2026-02-02 ER PT J AU NAVARRO, MD HORTELANO, P PERIAGO, JL PITA, ML AF NAVARRO, MD HORTELANO, P PERIAGO, JL PITA, ML TI EFFECT OF DIETARY OLIVE AND SUNFLOWER OILS ON THE LIPID-COMPOSITION OF THE AORTA AND PLATELETS AND ON BLOOD EICOSANOIDS IN RATS SO ARTERIOSCLEROSIS AND THROMBOSIS LA English DT Article DE OLIVE OIL; PLATELETS; AORTA; FATTY ACIDS; EICOSANOIDS ID FATTY-ACID COMPOSITION; SMOOTH-MUSCLE CELLS; ARACHIDONIC-ACID; LIVER-MICROSOMES; PLASMA-LIPIDS; PROSTAGLANDIN ENDOPEROXIDES; EICOSAPENTAENOIC ACID; MEDITERRANEAN DIET; CORN-OIL; PHOSPHOLIPIDS AB The effects on aortic and platelet fatty acid compositions and on blood levels of prostacyclin and thromboxane A2 of low- and high-fat diets containing olive oil or sunflower oil were studied. For 4 weeks, four groups of weanling rats were fed a basal diet containing 5% or 25% olive oil or sunflower oil. Rats fed olive oil diets showed higher levels of 18:1(n-9) and polyunsaturated fatty acids of the n-3 series and lower percentages of 18:0 and 18:2(n-6) in aortic and platelet phosphatidylcholine and phosphatidylethanolamine than those fed the sunflower oil diets. Arachidonic acid increased in platelet phosphatidylethanolamine and aortic phosphatidylcholine of rats fed the diet containing 5% sunflower oil compared with those fed 5% olive oil. Plasma 6-ketoprostaglandin F1-alpha increased in both groups of animals fed olive oil while these rats also showed the lowest levels of serum thromboxane B2 and plasma cholesterol. Olive oil feeding leads to changes in lipid metabolism of the vascular compartment that could be favorable in the prevention of thrombosis and atherosclerosis. C1 UNIV GRANADA,FAC PHARM,DEPT BIOCHEM & MOLEC BIOL,E-18071 GRANADA,SPAIN. 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Gracia Mouratidou, Theodora Santaliestra-Pasias, Alba Iglesia, Iris Gonzalez-Gil, Esther De Miguel-Etayo, Pilar Julian, Cristina Miguel-Berges, Mary Iguacel, Isabel Ruperez, Azahara Warnberg, Julia Nova, Esther Gomez, Sonia Diaz, Ligia Esperanza Romeo, Javier Veses, Ana Zapatera, Belen Pozo, Tamara Martinez, David Beghin, Laurent Iliescu, Catalina Von Berlepsch, Juliana Sichert-Hellert, Wolfgang Koeppen, Ellen Erhardt, Eva Csernus, Katalin Torok, Katalin Bokor, Szilvia Angster Nagy, Eniko Kovacs, Orsolya Repasi, Judit Codrington, Caroline Plada, Maria Papadaki, Angeliki Sarri, Katerina Viskadourou, Anna Hatzis, Christos Kiriakakis, Michael Tsibinos, George Vardavas, Constantine Sbokos, Manolis Protoyeraki, Eva Fasoulaki, Maria Stehle, Peter Pietrzik, Klaus Breidenassel, Christina Spinneker, Andre Al-Tahan, Jasmin Segoviano, Miriam Berchtold, Anke Bierschbach, Christine Blatzheim, Erika Schuch, Adelheid Pickert, Petra Castillo, Manuel J. Gutierrez, Angel Ortega, Francisco B. Ruiz, Jonatan R. Artero, Enrique G. Espana, Vanesa Jimenez-Pavon, David Chilton, Palma Sanchez-Munoz, Cristobal Cuenca, Magdalena Arcella, Davide Azzini, Elena Barrison, Emma Bevilacqua, Noemi Buonocore, Pasquale Catasta, Giovina Censi, Laura Ciarapica, Donatella D'Acapito, Paola Galfo, Myriam Le Donne, Cinzia Leclercq, Catherine Maiani, Giuseppe Mauro, Beatrice Mistura, Lorenza Pasquali, Antonella Piccinelli, Raffaela Polito, Angela Roccaldo, Romana Spada, Raffaella Sette, Stefania Zaccaria, Maria Vitaglione, Paola Montagnese, Concetta De Bourdeaudhuij, Ilse De Vriendt, Tineke Matthys, Christophe Vereecken, Carine de Maeyer, Mieke Ottevaere, Charlene Phillipp, Katharina Dietrich, Sabine Boriss-Riedl, Birgit Kubelka Marion Grammatikaki, Eva Bouloubasi, Zoi Cook, Tina Louisa Eleutheriou, Sofia Consta, Orsalia Moschonis, George Katsaroli, Ioanna Kraniou, George Papoutsou, Stab Keke, Despoina Petraki, Ioanna Bellou, Elena Tanagra, Sofia Kallianoti, Kostalenia Argyropoulou, Dionysia Tsikrika, Stamatoula Karaiskos, Christos Meirhaeghe, Aline Hagstromer, Maria Wenntof, Anita Hurtig Hallstrom, Lena Patterson, Emma Kwak, Lydia Rizzo, Nico Sanchez-Motero, Jackie Pico, Elena Navarro, Maite Viadel, Blanca Carreres, Jose Enrique Merino, Gema Sanjuan, Rosa Lorente, Maria Sanchez, Maria Jose Thomas, Sarah Allchurch, Elaine Burgess, Peter Astrom, Annika Sverken, Anna Broberg, Agneta Masson, Annick Lehoux, Claire Brabant, Pascal Pate, Philippe Fontaine, Laurence Sebok, Andras Kuti, Tunde Hegyi, Adrienn Maldonado, Cristina Llorente, Ana Garcia, Emilio von Fircks, Holger Hallberg, Marianne Lilja Messerer, Maria Larsson, Mats Fredriksson, Helena Adamsson, Viola Borjesson, Ingmar Fernandez, Laura Smillie, Laura Wills, Josephine Pedrero-Chamizo, Raquel Melendez, Agustin Valtuena, Jara Albers, Ulrike Benito, Pedro J. Lorente, Juan Jose Gomez Canada, David Urzanqui, Alejandro Torres, Rosa Maria Navarro, Paloma CA HELENA Study Grp TI Diet as a moderator in the association of sedentary behaviors with inflammatory biomarkers among adolescents in the HELENA study SO EUROPEAN JOURNAL OF NUTRITION LA English DT Article DE Sedentary behavior; Mediterranean diet; Low-grade inflammation; Moderation; Adolescents; HELENA study ID POLYUNSATURATED FATTY-ACIDS; HEALTHY LIFE-STYLE; PHYSICAL-ACTIVITY; EUROPEAN ADOLESCENTS; MEDITERRANEAN DIET; LIVER-DISEASE; ALANINE AMINOTRANSFERASE; BODY-FAT; INSULIN-RESISTANCE; INCREASED RISK AB Aim To assess if a healthy diet might attenuate the positive sedentary-inflammation relation, whereas an unhealthy diet may increase the effect of sedentary behaviors on inflammatory biomarkers. Methods In 618 adolescents (13-17 years) of the European HELENA study, data were available on body composition, a set of inflammation markers, and food intake assessed by a self-administered computerized 24h dietary recall for 2 days. A 9-point Mediterranean diet score and an antioxidant-rich diet z-score were used as dietary indices and tested as moderators. A set of low-grade inflammatory characteristics was used as outcome: several cytokines in an inflammatory ratio (IL-6, IL-10, TNF-alpha, TGF beta-1), C-reactive protein, three cell-adhesion molecules (sVCAM-1, sICAM-1, sE-selectin), three cardiovascular risk markers (GGT, ALT, homocysteine) and three immune cell types (white blood cells, lymphocytes, CD3). Sedentary behaviors were self-reported and analyzed as total screen time. Multiple linear regression analyses tested moderation by diet in the sedentary behaviors-inflammation association adjusted for age, sex, country, adiposity (sum of six skinfolds), parental education, and socio-economic status. Results Both diet scores, Mediterranean and antioxidant-rich diet, were significant protective moderators in the effect of sedentary behaviors on alanine-transaminase enzyme (P=0.014; P=0.027), and on the pro/anti-inflammatory cytokine ratio (P=0.001; P=0.004), but not on other inflammatory parameters. Conclusion A higher adherence to the Mediterranean diet or an antioxidant-rich diet may attenuate the onset of oxidative stress signs associated by sedentary behaviors, whereas a poor diet seems to increase inflammation. C1 [Arouca, Aline B.; Huybrechts, Inge; De Henauw, Stefaan; Michels, Nathalie] Univ Ghent, Fac Med & Hlth Sci, Dept Publ Hlth, De Pintelaan 185,Block K3-4th Floor, B-9000 Ghent, Belgium. [Santaliestra-Pasias, Alba M.; Moreno, Luis A.] Univ Zaragoza, IIS Aragon, Fac Ciencias Salud, GENUD Growth Exercise Nutr & Dev Res Grp,IA2, Zaragoza, Spain. [Marcos, Ascension] Inst Food Sci & Technol & Nutr, Dept Metab & Nutr, Madrid, Spain. [Widhalm, Kurt] Med Univ Vienna, Dept Pediat, Div Nutr & Metab, Vienna, Austria. [Molnars, Denes] Univ Pecs, Med Fac, Dept Pediat, Pecs, Hungary. [Manios, Yannis] Harokopio Univ, Sch Hlth Sci & Educ, Dept Nutr & Dietet, Athens, Greece. [Gottrand, Frederic] Univ Lille, Fac Med, Lille, France. [Kafatos, Anthony] Univ Crete, Fac Med, Iraklion, Greece. [Kersting, Mathilde] Ruhr Univ Bochum, Pediat Univ Clin, Res Dept Child Nutr, Bochum, Germany. [Sjostrom, Michael] Karolinska Inst, Dept Biosci, Unit Prevent Nutr, Huddinge, Sweden. [Gutierrez Sainzu, Angel] Granada Univ, Sch Med, Dept Physiol, Granada, Spain. [Ferrari, Marika] Res Ctr Food & Nutr, Council Agr Res & Econ, Rome, Italy. [Huybrechts, Inge] Int Agcy Res Canc, Lyon, France. [Gonzalez-Gross, Marcela] Univ Politecn Madrid, Fac Ciencias Actividad Fis & Deporte INEF, Dept Hlth & Human Performance, ImFINE Res Grp, Madrid, Spain. [Forsner, Maria] Dalarna Univ, Sch Educ Hlth & Social Studies, Falun, Sweden. [Forsner, Maria] Umea Univ, Dept Nursing, Umea, Sweden. [Moreno, Luis A.; Gonzalez-Gross, Marcela] Ctr Invest Biomed Red Fisiopatol Obesidad & Nutr, Madrid, Spain. C3 Ghent University; Ghent University Hospital; University of Zaragoza; Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Instituto de Ciencia y Tecnologia de Alimentos y Nutricion (ICTAN); Medical University of Vienna; University of Pecs; Harokopio University Athens; Universite de Lille; University of Crete; Ruhr University Bochum; Karolinska Institutet; University of Granada; Consiglio per la Ricerca in Agricoltura e L'analisi Dell'economia Agraria (CREA); World Health Organization; International Agency for Research on Cancer (IARC); Universidad Politecnica de Madrid; Dalarna University; Umea University; CIBER - Centro de Investigacion Biomedica en Red; CIBEROBN RP Arouca, AB (通讯作者)，Univ Ghent, Fac Med & Hlth Sci, Dept Publ Hlth, De Pintelaan 185,Block K3-4th Floor, B-9000 Ghent, Belgium. EM aline.barbedoarouca@ugent.be RI LABAYEN, IDOIA/C-7661-2009; Ortega, Francisco B/B-4002-2010; Azzini, Elena/AAI-9125-2021; gottrand, frederic/W-8000-2018; Molnár, Dénes/AAB-6820-2022; Warnberg, Julia/G-1390-2011; De+Bourdeaudhuij, Ilse/AAC-5528-2019; SANCHEZ-PEREZ, MARIA JOSE/HOC-7747-2023; Jiménez-Pavón, David/M-9005-2015; Meirhaeghe, Aline/E-4663-2015; Castillo Garzon, Manuel Joaquin/AAB-6811-2019; De Miguel-Etayo, Pilar/B-5258-2014; gottrand, frederic/G-7370-2015; Chillón, Palma/E-5634-2014; González Gil, Esther María/AAA-8040-2020; Montagnese, Concetta/AAC-8706-2022; Patterson, Emma/H-5080-2019; Huybrechts, Inge/ITT-7052-2023; Iglesia, Iris/C-1841-2014; Catasta, Giovina/HWQ-3541-2023; RUIZ, JONATAN/M-1338-2015; Plada, Maria/PEX-8461-2025; Manios, Yannis/AAM-8953-2021; Casajús Mallén, José Antonio/K-5718-2017; Tsikrika, Stamatoula/AAX-4205-2021; Iguacel, Isabel/ABC-7789-2021; Matthys, Christophe/AAO-1596-2020; Julián, Cristina/C-7661-2009; Moreno Aznar, Luis A/S-1780-2019; Stehle, Peter/ITU-6185-2023; Peinado, Pedro/L-3531-2019; Peero-Chamizo, Raquel/Z-3738-2019; Ruperez, Azahara I/L-3771-2019; Artero, Enrique G/AAA-7876-2019; Moschonis, George/AAM-9616-2021; Mouratidou, Theodora/N-3789-2015; Censi, Laura/AAN-1674-2020; Sanchez, Ascension/K-4965-2014; Matthys, Christophe/I-4203-2016; Vitaglione, Paola/B-2864-2010; TOMAS, CONCEPCION/L-6162-2014; Michels, Nathalie/C-2819-2012; Gutierrez Sainz, Angel/AAB-6809-2019; Mouratidou, Theodora/AAG-9985-2021; Gonzalez-Gross, Marcela/W-8000-2018; BEGHIN, Laurent/D-4294-2011; Vardavas, Constantine/O-4961-2016; Prieto, Ligia/K-4887-2014; Censi, Laura/E-5634-2014; martinez, david/JCE-5144-2023; Marco-Ruiz, Luis/LPQ-6748-2024; Vicente Rodríguez, Germán/J-9846-2016; Maes, Lea/D-6014-2013 OI LABAYEN, IDOIA/0000-0002-4334-3287; Ortega, Francisco B/0000-0003-2001-1121; Azzini, Elena/0000-0002-1971-1668; gottrand, frederic/0000-0002-5290-0436; Warnberg, Julia/0000-0002-8408-316X; SANCHEZ-PEREZ, MARIA JOSE/0000-0003-4817-0757; Jiménez-Pavón, David/0000-0002-8977-4744; Castillo Garzon, Manuel Joaquin/0000-0002-1196-9488; De Miguel-Etayo, Pilar/0000-0001-6173-5850; gottrand, frederic/0000-0002-5290-0436; Chillón, Palma/0000-0003-0862-8989; Forsner, Maria/0000-0003-1169-2172; González Gil, Esther María/0000-0003-2005-8229; Montagnese, Concetta/0000-0002-3662-2413; RUIZ, JONATAN/0000-0002-7548-7138; Manios, Yannis/0000-0001-6486-114X; Casajús Mallén, José Antonio/0000-0002-7215-6931; Julián, Cristina/0000-0002-8374-3410; Iguacel, Isabel/0000-0003-4242-5464; Matthys, Christophe/0000-0003-1770-6862; Julián, Cristina/0000-0002-8374-3410; Urzanqui Velasco, Alejano/0009-0007-5299-4691; Roccaldo, Romana/0000-0003-2976-3864; Moreno Aznar, Luis A/0000-0003-0454-653X; Peero-Chamizo, Raquel/0000-0002-3866-4692; Ruperez, Azahara I/0000-0002-3850-8235; Artero, Enrique G/0000-0002-2618-6128; Moschonis, George/0000-0003-3009-6675; Mouratidou, Theodora/0000-0002-3726-1066; Censi, Laura/0000-0002-8769-6914; Matthys, Christophe/0000-0003-1770-6862; Vitaglione, Paola/0000-0002-6608-5209; Michels, Nathalie/0000-0002-3069-7254; Gutierrez Sainz, Angel/0000-0003-2788-2739; Mouratidou, Theodora/0000-0002-3726-1066; Gonzalez-Gross, Marcela/0000-0001-7757-3235; BEGHIN, Laurent/0000-0001-5369-3910; Vardavas, Constantine/0000-0003-0171-9570; Censi, Laura/0000-0002-8769-6914; Vicente Rodríguez, Germán/0000-0002-4303-4097; Valtueña, Jara/0000-0002-9377-8668; FU European Community Sixth RTD Framework Programme [FOODCT-2005-007034] FX The HELENA Study was carried out with the financial support of the European Community Sixth RTD Framework Programme (Contract FOODCT-2005-007034). The writing group takes sole responsibility for the content of this article. The European Community is not liable for any use that may be made of the information contained therein. 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J. Nutr. PD AUG PY 2019 VL 58 IS 5 BP 2051 EP 2065 DI 10.1007/s00394-018-1764-4 PG 15 WC Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI) SC Nutrition & Dietetics GA IK3MJ UT WOS:000476492800027 PM 29974229 DA 2026-02-02 ER PT J AU Sinanoglou, VJ Proestos, C Lantzouraki, DZ Calokerinos, AC Miniadis-Meimaroglou, S AF Sinanoglou, Vassilia J. Proestos, Charalampos Lantzouraki, Dimitra Z. Calokerinos, Antony C. Miniadis-Meimaroglou, Sofia TI Lipid evaluation of farmed and wild meagre (Argyrosomus regius) SO EUROPEAN JOURNAL OF LIPID SCIENCE AND TECHNOLOGY LA English DT Article DE Argyrosomus regius; Farmed meagre; Fatty acids; Lipids; Wild meagre ID ESSENTIAL FATTY-ACIDS; PROXIMATE COMPOSITION; CHEMICAL-COMPOSITION; CHOLESTEROL; SEA; MUSCLE; LIVER; ASSO AB Proximate, lipid, and fatty acid composition of farmed and wild meagre (Argyrosomus regius) muscle, head, skin, and liver, were comparatively studied. Distinct differences were evident in the lipid and fatty acid composition among different tissues of farmed and wild meagre. Total lipid content of the farmed fish parts was significantly higher than that of the wild fish. Neutral lipids, mainly triglycerides, predominated in muscle, head, and skin for both fish. The fact that muscle fat was found significantly lower in triglycerides (TG) concentration than head and skin indicates that muscle consumption after head and skin removal may contribute to a healthy diet. Wild fish muscle, head, and skin fat was found to have significant contribution to the phosphatidylcholine daily intake in the human diet. A. regius liver was also found to be an excellent source of glycerophospholipids. Fatty acid patterns of muscle, head and skin of farmed fish were found to be affected by the feed. MUFA/saturated fatty acid (SFA), PUFA/SFA, and DHA/eicosapentaenoic acid (EPA) ratios were found significantly higher in muscle, head, and skin TL of wild fish compared to the farmed one. Farmed fish muscle could provide similar amount of EPA+DHA and significantly higher amount of -3 PUFA compared to wild fish muscle. Practical applications:Argyrosomus regius is considered a promising fish species for aquaculture due to its tasty meat and great market acceptance in the Mediterranean countries. Hence it is important to determine its lipid and fatty acid content of both farmed and wild fish edible parts (muscle, head, and skin) for nutritional purposes. Remaining parts (such as liver) could still be interesting to analyze for possible use in other food or nutraceutical applications. Here we compare the distribution pattern of lipids and fatty acids of muscles, heads, skin, and liver in wild and farmed A. regius, fed a commercial diet. Furthermore, the present study is a novel comparison between cultured and wild fish species A. regius in terms of their proximate and fatty acid composition. C1 [Sinanoglou, Vassilia J.] Technol Educ Inst Athens, Dept Food Technol, Instrumental Food Anal Lab, Ag Spyridonos 12210, Egaleo, Greece. [Proestos, Charalampos; Lantzouraki, Dimitra Z.; Miniadis-Meimaroglou, Sofia] Univ Athens, Dept Chem, Food Chem Lab, Athens 11528, Greece. [Calokerinos, Antony C.] Univ Athens, Dept Chem, Analyt Chem Lab, Athens 11528, Greece. C3 National & Kapodistrian University of Athens; National & Kapodistrian University of Athens RP Sinanoglou, VJ (通讯作者)，Technol Educ Inst Athens, Dept Food Technol, Instrumental Food Anal Lab, Ag Spyridonos 12210, Egaleo, Greece. EM v_sinanoglou@yahoo.gr RI Calokerinos, Antony/R-5064-2019; Lantzouraki, Dimitra/J-4818-2019; Sinanoglou, Vassilia/AAR-7532-2021; Proestos, Charalampos/H-4348-2019 OI Calokerinos, Antony/0000-0002-4875-2231; Lantzouraki, Dimitra/0000-0001-5598-1959; Sinanoglou, Vassilia/0000-0001-8109-5563; Proestos, Charalampos/0000-0002-3450-5969 FU Special Research Account of National and Kapodistrian University of Athens [11540/2012] FX This research was supported in part by the Special Research Account of National and Kapodistrian University of Athens under the project with number 11540/2012. 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Ortega, E. Laguna, J. C. Alegret, M. Gilabert, R. Bargallo, N. Buil-Cosiales, P. Toledo, E. Garcia-Arellano, A. Cenoz-Osinaga, J. C. Lecea-Juarez, O. Razquin, C. Sanchez-Tainta, A. Sanjulian, B. Diez-Espino, J. Zazpe, I Basterra-Gortari, Fj Eguaras, S. Goni, E. Vazquez, Z. Bes-Rastrollo, M. Gea, A. Martin-Calvo, N. Berrade, N. Marti, A. Martinez-Lapiscina, E. H. Garcia-Lopez, M. Cervantes, S. Barcena Amigo, F. Oreja Arrayago, C. Lasanta Saez, M. J. Quintana Pedraza, L. Cia Lecumberri, P. Elcarte Lopez, T. Forcen Alonso, T., I Alvarez-Alvarez Guasch-Ferre, M. Gonzalez, R. Molina, C. Marquez, F. Babio, N. Rosello, Garcia Diaz-Lopez, A. Martin, F. Tort, R. Isach, A. Becerra, N. Ferreira, C. Cabre, J. J. Fernandez-Ballart, J. Ibarrola-Jurado, N. Mestres, G. Rosique-Esteban, N. Alegret, C. Martinez, P. Millan, S. Pinol, J. L. Basora, T. Salas-Huetos, A. Hernandez, J. M. Carrasco, P. Ortega-Azorin, C. Asensio, E. M. Osma, R. Barragan, R. Frances, F. Guillen, M. Gonzalez, J. J. Saiz, C. 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CA PREDIMED Study Investigators TI A Mediterranean Diet Rich in Extra-Virgin Olive Oil Is Associated with a Reduced Prevalence of Nonalcoholic Fatty Liver Disease in Older Individuals at High Cardiovascular Risk SO JOURNAL OF NUTRITION LA English DT Article DE hepatic steatosis; Mediterranean diet; olive oil; nuts; PREDIMED; dietary fat ID HEPATIC STEATOSIS; INSULIN-RESISTANCE; METABOLIC SYNDROME; GLUCOSE; POLYPHENOLS; MODULATION; COMPONENTS; IMPROVES; INDEX; NUTS AB Background: Adherence to a Mediterranean diet (MedDiet) is thought to reduce liver steatosis. Objectives: To explore the associations with liver steatosis of 3 different diets: aMedDiet+ extra-virgin olive oil (EVOO), MedDiet + nuts, or a control diet. Methods: This was a subgroup analysis nested within a multicenter, randomized, parallel-group clinical trial, PREvencion con DIeta MEDiterranea (PREDIMED trial: ISRCTN35739639), aimed at assessing the effect of a MedDiet on the primary prevention of cardiovascular disease. One hundred men and women (mean age: 64 +/- 6 y), at high cardiovascular risk (62% with type 2 diabetes) from the Bellvitge-PREDIMED center were randomly assigned to a MedDiet supplemented with EVOO, a MedDiet supplemented with mixed nuts, or a control diet (advice to reduce all dietary fat). No recommendations to lose weight or increase physical activity were given. Main measurements were the percentage of liver fat and the diagnosis of steatosis, which were determined by NMR imaging. The association of diet with liver fat content was analyzed by bivariate analysis after a median follow-up of 3 y. Results: Baseline adiposity and cardiometabolic risk factors were similar among the 3 treatment arms. At 3 y after the intervention hepatic steatosis was present in 3 (8.8%), 12 (33.3%), and 10 (33.3%) of the participants in the MedDiet + EVOO, MedDiet + nuts, and control diet groups, respectively (P = 0.027). Respective mean values of liver fat content were 1.2%, 2.7%, and 4.1% (P = 0.07). A tendency toward significance was observed for the MedDiet + EVOO group compared with the control group. Median values of urinary 12(S)-hydroxyeicosatetraenoic acid/creatinine concentrations were significantly (P = 0.001) lower in the MedDiet + EVOO (2.3 ng/mg) than in the MedDiet + nuts (5.0 ng/mg) and control (3.9 ng/mg) groups. No differences in adiposity or glycemic control changes were seen between groups. Conclusions: An energy-unrestricted MedDiet supplemented with EVOO, a food with potent antioxidant and anti-inflammatory properties, is associated with a reduced prevalence of hepatic steatosis in older individuals at high cardiovascular risk. C1 [Pinto, Xavier; Fanlo-Maresma, Marta; Corbella, Emili; Corbella, Xavier] Hosp Univ Bellvitge IDIBELL, Internal Med, Lipids & Vasc Risk Unit, Barcelona, Spain. [Pinto, Xavier; Corbella, Emili; Moreno, Juan J.; Casas, Rosa; Estruch, Ramon; Corella, Dolores; Bullo, Monica; Ruiz-Canela, Miguel; Castaner, Olga; Alfredo Martinez, J.; Ros, Emilio] Inst Salud Carlos III, Ciber Fisiopatol Obesidad & Nutr CIBEROBN, Madrid, Spain. [Corbella, Xavier] Univ Int Catalunya, Fac Med & Hlth Sci, Barcelona, Spain. [Teresa Mitjavila, M.] Univ Barcelona, Fac Biol, Dept Biol Cellular Fisiol & Immunol, INSA UB, Barcelona, Spain. [Moreno, Juan J.] Univ Barcelona, Fac Farm & Ciencias Alimentac, Dept Nutr Ciencias Alimentac & Gastron, INSA UB, Campus Alimentac Torribera, Barcelona, Spain. [Casas, Rosa; Estruch, Ramon] Hosp Clin Barcelona, Inst Invest Biomed August Pi & Sunyer IDIBAPS, Dept Internal Med, Barcelona, Spain. [Corella, Dolores] Univ Valencia, Dept Prevent Med, Valencia, Spain. [Bullo, Monica] Univ Rovira & Virgili, Hosp Univ St Joan, Inst Invest Sanitaria Pere Virgili, Human Nutr Dept, Reus, Spain. [Ruiz-Canela, Miguel] Univ Navarra, Sch Med, Dept Prevent Med & Publ Hlth, Pamplona, Spain. [Castaner, Olga] Inst Hosp del Mar Invest Med, Cardiovasc & Nutr Res Grp, Barcelona, Spain. [Alfredo Martinez, J.] Univ Navarra, Dept Nutr & Physiol, Pamplona, Spain. [Alfredo Martinez, J.] IMDEA Food, Madrid, Spain. [Ros, Emilio] Hosp Clin Barcelona, Nutr Serv, IDIBAPS, Endocrinol & Nutr Serv, Barcelona, Spain. [Estruch, R.; Martinez-Gonzalez, M. A.; Corella, D.; Fito, M.; Ros, E.; Salas-Salvado, J.; Aros, F.; Aldamiz-Echevarria, M.; Alonso-Gomez, A. M.; Berjon, J.; Forga, L.; Gallego, J.; Garcia-Layana, A.; Larrauri, A.; Portu-Zapirain, J.; Timiraos, J.; Covas, M., I; Perez-Heras, A.; Serra-Mir, M.; Pi-Sunyer, X.; Gonzalez, C. A.; Hu, F. B.; Sabate, J.] Hosp Univ Bellvitge IDIBELL, Barcelona, Spain. [de la Cruz, E.; Galera, A.; Gimenez-Garcia, M.; Lafuente, H.; Trias, F.; Sarasa, I; Figueras, R.; Liceran, M.; Pallarols, C.; Esteve, V; Storniolo, C.] Hosp Clin Barcelona, Inst Invest Biomed August Pi & Sunyer, Barcelona, Spain. [Sala-Vila, A.; Valls-Pedret, C.; Vinas, C.; Casas, R.; Medina-Remon, A.; Romero, S.; Baena, J. M.; Garcia, M.; Oller, M.; Amat, J.; Duaso, I; Garcia, Y.; Iglesias, C.; Simon, C.; Quinzavos, L.; Parra, L.; Liroz, M.; Benavent, J.; Clos, J.; Pla, I; Amoros, M.; Bonet, M. T.; Martin, M. T.; Sanchez, M. S.; Altirriba, J.; Manzano, E.; Altes, A.; Cofan, M.; Domenech, M.; Freitas-Simoes, T. M.; Roth, I; Amor, A. J.; Ortega, E.; Laguna, J. C.; Alegret, M.; Gilabert, R.; Bargallo, N.] Univ Navarra, Primary Care Ctr, Pamplona, Spain. [Buil-Cosiales, P.; Toledo, E.; Garcia-Arellano, A.; Cenoz-Osinaga, J. C.; Lecea-Juarez, O.; Razquin, C.; Sanchez-Tainta, A.; Sanjulian, B.; Diez-Espino, J.; Zazpe, I; Basterra-Gortari, Fj; Eguaras, S.; Goni, E.; Vazquez, Z.; Bes-Rastrollo, M.; Gea, A.; Martin-Calvo, N.; Berrade, N.; Marti, A.; Martinez-Lapiscina, E. H.; Garcia-Lopez, M.; Cervantes, S.; Barcena Amigo, F.; Oreja Arrayago, C.; Lasanta Saez, M. J.; Quintana Pedraza, L.; Cia Lecumberri, P.; Elcarte Lopez, T.; Forcen Alonso, T., I; Alvarez-Alvarez] Univ Rovira & Virgili, Reus, Spain. [Guasch-Ferre, M.; Gonzalez, R.; Molina, C.; Marquez, F.; Babio, N.; Rosello, Garcia; Diaz-Lopez, A.; Martin, F.; Tort, R.; Isach, A.; Becerra, N.; Ferreira, C.; Cabre, J. J.; Fernandez-Ballart, J.; Ibarrola-Jurado, N.; Mestres, G.; Rosique-Esteban, N.; Alegret, C.; Martinez, P.; Millan, S.; Pinol, J. L.; Basora, T.; Salas-Huetos, A.; Hernandez, J. M.; Saez, G.] Univ Valencia, Valencia, Spain. [Carrasco, P.; Ortega-Azorin, C.; Asensio, E. M.; Osma, R.; Barragan, R.; Frances, F.; Guillen, M.; Gonzalez, J. J.; Saiz, C.; Portoles, O.; Gimenez, F. J.; Coltell, O.; Fernandez-Carrion, R.; Guillem-Saiz, P.; Gonzalez-Monje, I; Quiles, L.; Pascual, V; Riera, C.; Pages, M. A.; Godoy, D.; Carratala-Calvo, A.; Sanchez-Navarro, S.; Valero-Barcelo, C.] Hosp del Mar, Res Inst, Barcelona, Spain. [Fito, M.; Vila, J.; Subirana, I; Tello, S.; de la Torre, R.; Munoz-Aguayo, D.; Elosua, R.; Marrugat, J.; Schroder, H.; Molina, N.; Maestre, E.; Rovira, A.; Farre, M.] Univ Hosp Alava, Vitoria, Spain. [Aros, F.; Limiraos, J.; Salaverria, I; Rekondo, J.; Bello, M. C.; del Hierro, T.; Algorta, J.; Francisco, S.; Alonso, A.; San Vicente, J.; Sanz, E.; Felipe, I; Alonso Gomez, A.; Loma-Osorio, A.] Univ Malaga, Malaga, Spain. [Gomez-Gracia, E.; Fernandez-Crehuet, J.; Gutierrez-Bedmar, M.; Benitez Pont, R.; Bianchi Alba, M.; Warnberg, J.; Gomez-Huelgas, R.; Martinez-Gonzalez, J.; Velasco Garcia, V.; de Diego Salas, J.; Baca Osorio, A.; Gil Zarzosa, J.; Sanchez Luque, J. J.; Vargas Lopez, E.] Palma Inst Hlth Res IdISPa, Palma De Mallorca, Spain. [Romaguera, D.; Garcia-Valdueza, M.; Monino, M.; Yanez, A.; Proenza, A.; Prieto, R.; Munuera, S.; Vivo, M.; Bestard, F.; Munar, J. A.; Coll, L.; Fiol, F.; Ginard, M.; Jover, A.; Garcia, J.] Dist Sanitario Atenc Primaria Sevilla, Dept Family Med, Seville, Spain. [Leal, M.; Martinez, E.; Santos-Lozano, J. M.; Ortega-Calvo, M.; Roman, P.; Jose Garcia, F.; Iglesias, P.; Corchado, Y.; Mellado, L.; Miro-Moriano, L.; Lozano-Rodriguez, J. M.; Dominguez-Espinaco, C.; Vaquero-Diaz, S.] Univ Barcelona, Sch Pharm, Barcelona, Spain. [Lopez-Sabater, M. C.; Castellote-Bargallo, A., I; Quifer-Rada, P.; Tresserra-Rimbau, A.] Univ Las Palmas dc Gran Canaria, IUIBS, Las Palmas Gran Canaria, Spain. [Alvarez-Perez, J.; Diaz-Benitez, E. M.; Sanchez-Villegas, A.; Casanas-Quintana, L. T.; Perez-Cabrera, J.; Ruano-Rodriguez, C.; Bautista-Castano, I; Sarmiento de la Fe, F.; Garcia Pastor, J. A.; Diaz-Gonzalez, B., V; Castillo Anzalas, J. M.; Sosa-Also, R. E.; Medina-Ponce, J.] Catalan Inst Hlth, Primary Care Div, Barcelona, Spain. [Cabezas, C.; Vinyoles, E.; Rovira, M. A.; Garcia, L.; Flores, G.; Verdu, J. M.; Baby, P.; Ramos, A.; Mengual, L.; Roura, P.; Yuste, M. C.; Guarner, A.; Santamaria, M., I; Mata, M.; de Juan, C.; Brau, A.] CSIC, Inst Grasa, Seville, Spain. [Ruiz-Gutierrez, V; Sanchez Perona, J.; Montero Romero, E.; Garcia-Garcia, M.; Jurado-Ruiz, E.; Portillo, M. P.] Univ Basque Country, Leioa, Spain. [Tur, J.] Univ Balearic Isl, Palma De Mallorca, Illes Balears, Spain. C3 Institut d'Investigacio Biomedica de Bellvitge (IDIBELL); Bellvitge University Hospital; Instituto de Salud Carlos III; CIBER - Centro de Investigacion Biomedica en Red; CIBEROBN; Universitat Internacional de Catalunya (UIC); University of Barcelona; University of Barcelona; University of Barcelona; Hospital Clinic de Barcelona; IDIBAPS; University of Valencia; Universitat Rovira i Virgili; Institut d'Investigacio Sanitaria Pere Virgili (IISPV); University of Navarra; Hospital del Mar Research Institute; Hospital del Mar; University of Navarra; IMDEA Food Institute; University of Barcelona; Hospital Clinic de Barcelona; IDIBAPS; Institut d'Investigacio Biomedica de Bellvitge (IDIBELL); Bellvitge University Hospital; University of Barcelona; Hospital Clinic de Barcelona; IDIBAPS; University of Navarra; Universitat Rovira i Virgili; University of Valencia; Hospital del Mar Research Institute; Hospital del Mar; Universidad de Malaga; University of Barcelona; Institut Catala de la Salut (ICS); Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Instituto de la Grasa (IG); University of Basque Country; Universitat de les Illes Balears RP Pintó, X (通讯作者)，Hosp Univ Bellvitge IDIBELL, Internal Med, Lipids & Vasc Risk Unit, Barcelona, Spain.; Pintó, X (通讯作者)，Inst Salud Carlos III, Ciber Fisiopatol Obesidad & Nutr CIBEROBN, Madrid, Spain. EM xpinto@bellvitgehospital.cat RI Sánchez-Navarro, Sonia/OKR-6185-2025; Pintó Sala, Xavier/AGI-4297-2022; Corbella, Emili/AGI-4105-2022; Portillo, Maria/ABH-2374-2020; Vinyoles, Ernest/GRX-4615-2022; Leal Londoño, Maria/KQV-4923-2024; DEL FIOL, FERNANDO/H-1288-2012; Cabré Vila, Juan José/AAN-5059-2020; Larrauri, Amparo/Q-9613-2017; Castañer Niño, Olga/F-1533-2013; Lopez, Enrique/HKW-0884-2023; Guasch-Ferré, Marta/JJM-4619-2023; Algorta, Jaime/K-9002-2012; Marisa, Guillén/AAJ-8250-2020; Ortega-Calvo, Manuel/I-4089-2019; BES-RASTROLLO, MAIRA/A-1329-2009; Salas-Salvadó, Jordi/C-7229-2017; ELOSUA, ROBERTO/E-3449-2018; Salas-Huetos, Albert/A-8509-2011; Gutiérrez-Bedmar, Mario/F-2364-2018; Bulló, Mònica/F-2925-2016; Martín-Calvo, Nerea/D-1727-2017; Bautista-Castaño, Inmaculada/AFT-1699-2022; Ortega Martinez de Victoria, Emilio/AAB-2072-2022; BES-RASTROLLO, MAIRA/AAE-7669-2019; Yañez, Aina M/AAF-7087-2021; Fernandez-Carrion, Rebeca/AAA-5713-2019; Razquin, Cristina/H-2366-2017; Ruiz-Canela, Miguel/JYP-1794-2024; Bargallo, Nuria/G-6854-2016; Moñino, Manuel/IWV-3973-2023; Sanchez Villegas, Almudena/T-6733-2019; Casas, Rosa/ABD-1915-2020; Moreno, Juan/AAA-1312-2019; BABIO SÁNCHEZ, NANCY/AAN-2715-2020; Warnberg, Julia/G-1390-2011; Romaguera, Dora/AAB-2852-2020; corbella, xavier/A-2928-2019; Casas Klein, Renato/KXS-1670-2024; Estruch, Ramon/AAZ-3723-2020; Pla, Indira/AAI-4045-2020; Schroder, Helmut/G-2586-2015; Amorós, Miquel/AAB-3434-2020; Mitjavila, Maria/D-7474-2014; ÁLVAREZ-PÉREZ, JACQUELINE/V-4360-2017; González, J./L-6687-2014; Bello, maria/PBV-9465-2025; Corella, Dolores/L-9888-2014; Iglesias, P/AAU-1011-2020; Perona, J/B-9721-2014; ALONSO GOMEZ, ANGEL/HLG-2476-2023; Tur, Josep/AAE-5748-2020; gimenez-fuentesguerra, francisco/G-7910-2016; Gomez-Huelgas, Ricardo/ABF-5100-2021; Carrasco, Paula/D-7864-2019; Martínez, J./K-8709-2014; Laguna, JCLaguna/C-5481-2017; Tresserra-Rimbau, Anna/ABD-1099-2020; Cofan, Montserrat/R-8326-2018; Martínez-Lapiscina, Elena/L-1161-2014; Coltell, Oscar/AAA-9936-2019 OI Pintó Sala, Xavier/0000-0002-2216-2444; Corbella, Emili/0000-0001-8818-1907; Amor Fernández, Antonio J/0000-0001-9237-0903; Vinyoles, Ernest/0000-0002-8725-9431; Sabate, Joan/0000-0002-9063-9785; Cabré Vila, Juan José/0000-0003-1082-6861; Castañer Niño, Olga/0000-0003-3169-997X; Domenech, Monica/0000-0001-5447-6686; Salaverría Lete, Itziar/0000-0002-9504-4668; GARCIA LAYANA, ALFREDO/0000-0001-5732-2797; Marrugat, Jaume/0000-0003-3320-554X; Guasch-Ferré, Marta/0000-0001-8525-1404; Algorta, Jaime/0000-0002-7042-5675; Vila-Domènech, Joan Salvador/0000-0002-0413-9291; Gómez Gracia, Enrique/0000-0002-1281-5798; Marisa, Guillén/0000-0001-5802-6316; Ortega-Calvo, Manuel/0000-0003-2391-0106; Fabiola, Márquez-Sandoval/0000-0002-4530-3940; BES-RASTROLLO, MAIRA/0000-0002-9139-4206; Gea, Alfredo/0000-0002-2229-4690; Salas-Salvadó, Jordi/0000-0003-2700-7459; ELOSUA, ROBERTO/0000-0001-8235-0095; Salas-Huetos, Albert/0000-0001-5914-6862; Cabezas, Carmen/0000-0002-4291-0454; Gutiérrez-Bedmar, Mario/0000-0003-0898-8212; Bulló, Mònica/0000-0002-0218-7046; Martín Luján, Francisco M/0000-0003-0359-3588; Martín-Calvo, Nerea/0000-0001-7549-1455; Bautista-Castaño, Inmaculada/0000-0001-9257-8739; Ortega Martinez de Victoria, Emilio/0000-0002-2217-8905; BES-RASTROLLO, MAIRA/0000-0002-9139-4206; Yañez, Aina M/0000-0001-8527-3937; Mestres, Gaspar/0000-0002-8699-7037; Buil-Cosiales, Pilar/0000-0002-8586-577X; Razquin, Cristina/0000-0003-3480-2645; Ruiz-Canela, Miguel/0000-0002-7684-2787; Bargallo, Nuria/0000-0001-6284-5402; Moñino, Manuel/0000-0003-1230-8013; Sanchez Villegas, Almudena/0000-0001-7733-9238; Casas, Rosa/0000-0002-0211-9166; BABIO SÁNCHEZ, NANCY/0000-0003-3527-5277; Quiles Guiñau, Laura/0000-0002-4596-2313; Warnberg, Julia/0000-0002-8408-316X; Guillem Saiz, Patricia/0000-0003-4422-5538; Romaguera, Dora/0000-0002-5762-8558; corbella, xavier/0000-0001-9889-0272; Díaz-López, Andrés/0000-0002-7500-5629; FU Instituto de Salud Carlos III [RD06/0045/0007, CB06/03/0028, CB12/03/30012, PI13/01123, JR14/00008] FX This work was supported by the Instituto de Salud Carlos III (RD06/0045/0007, CB06/03/0028, CB12/03/30012, PI13/01123, and JR14/00008). The CIBER de Fisiopatologia de la Obesidad y Nutricion (CIBEROBN) is an initiative of the Instituto de Salud Carlos III. 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Nutr. PD NOV PY 2019 VL 149 IS 11 BP 1920 EP 1929 DI 10.1093/jn/nxz147 PG 10 WC Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Nutrition & Dietetics GA JY3NE UT WOS:000504324800009 PM 31334554 OA Bronze DA 2026-02-02 ER PT J AU Martin-Piedra, L Alcala-Diaz, JF Gutierrez-Mariscal, FM de Larriva, AAP Romero-Cabrera, JL Torres-Pena, JD Caballero-Villarraso, J Luque, RM Perez-Martinez, P Lopez-Miranda, J Delgado-Lista, J AF Martin-Piedra, Laura Alcala-Diaz, Juan F. Gutierrez-Mariscal, Francisco M. Arenas de Larriva, Antonio P. Romero-Cabrera, Juan L. Torres-Pena, Jose D. Caballero-Villarraso, Javier Luque, Raul M. Perez-Martinez, Pablo Lopez-Miranda, Jose Delgado-Lista, Javier TI Evolution of Metabolic Phenotypes of Obesity in Coronary Patients after 5 Years of Dietary Intervention: From the CORDIOPREV Study SO NUTRIENTS LA English DT Article DE obesity metabolic phenotypes; metabolically healthy obese; metabolically unhealthy obese; fatty liver index; diet intervention; Mediterranean diet; low-fat diet; coronary patients ID BODY-FAT DISTRIBUTION; HEALTHY OBESITY; ADIPOSE-TISSUE; CARDIOVASCULAR-DISEASE; EUROPEAN-SOCIETY; TASK-FORCE; INFLAMMATION; ASSOCIATION; PREVENTION; MASS AB Background: Obesity phenotypes with different metabolic status have been described previously. We analyzed metabolic phenotypes in obese coronary patients during a 5-year follow-up, and examined the factors influencing this evolution. Methods: The CORDIOPREV study is a randomized, long-term secondary prevention study with two healthy diets: Mediterranean and low-fat. All obese patients were classified as either metabolically healthy obese (MHO) or metabolically unhealthy obese (MUO). We evaluated the changes in the metabolic phenotypes and related variables after 5 years of dietary intervention. Results: Initially, 562 out of the 1002 CORDIOPREV patients were obese. After 5 years, 476 obese patients maintained their clinical and dietary visits; 71.8% of MHO patients changed to unhealthy phenotypes (MHO-Progressors), whereas the MHO patients who maintained healthy phenotypes (MHO-Non-Progressors) lost more in terms of their body mass index (BMI) and had a lower fatty liver index (FLI-score) (p < 0.05). Most of the MUO (92%) patients maintained unhealthy phenotypes (MUO-Non-Responders), but 8% became metabolically healthy (MUO-Responders) after a significant decrease in their BMI and FLI-score, with improvement in all metabolic criteria. No differences were found among dietary groups. Conclusions: A greater loss of weight and liver fat is associated with a lower progression of the MHO phenotype to unhealthy phenotypes. Likewise, a marked improvement in these parameters is associated with regression from MUO to healthy phenotypes. C1 [Martin-Piedra, Laura; Alcala-Diaz, Juan F.; Gutierrez-Mariscal, Francisco M.; Arenas de Larriva, Antonio P.; Romero-Cabrera, Juan L.; Torres-Pena, Jose D.; Perez-Martinez, Pablo; Lopez-Miranda, Jose; Delgado-Lista, Javier] Reina Sofia Univ Hosp, Internal Med Unit, Lipids & Atherosclerosis Unit, Cordoba 14004, Spain. [Martin-Piedra, Laura; Alcala-Diaz, Juan F.; Gutierrez-Mariscal, Francisco M.; Arenas de Larriva, Antonio P.; Romero-Cabrera, Juan L.; Torres-Pena, Jose D.; Perez-Martinez, Pablo; Lopez-Miranda, Jose; Delgado-Lista, Javier] Maimonides Inst Biomed Res Cordoba IMIBIC, Cordoba 14004, Spain. [Martin-Piedra, Laura; Alcala-Diaz, Juan F.; Gutierrez-Mariscal, Francisco M.; Arenas de Larriva, Antonio P.; Romero-Cabrera, Juan L.; Torres-Pena, Jose D.; Perez-Martinez, Pablo; Lopez-Miranda, Jose; Delgado-Lista, Javier] Univ Cordoba, Dept Med & Surg Sci, Cordoba 14004, Spain. [Martin-Piedra, Laura; Alcala-Diaz, Juan F.; Gutierrez-Mariscal, Francisco M.; Arenas de Larriva, Antonio P.; Romero-Cabrera, Juan L.; Torres-Pena, Jose D.; Luque, Raul M.; Perez-Martinez, Pablo; Lopez-Miranda, Jose; Delgado-Lista, Javier] Inst Salud Carlos III, CIBER Physiopathol Obes & Nutr, Madrid 28029, Spain. [Caballero-Villarraso, Javier] Univ Cordoba, Reina Sofia Univ Hosp, Maimonides Inst Biomed Res Cordoba, Biochem Lab, Cordoba 14004, Spain. [Luque, Raul M.] Univ Cordoba, Dept Cell Biol Physiol & Immunol, Maimonides Inst Biomed Res Cordoba, Cordoba 14004, Spain. C3 Universidad de Cordoba; CIBER - Centro de Investigacion Biomedica en Red; CIBEROBN; Instituto de Salud Carlos III; Universidad de Cordoba; Universidad de Cordoba RP Lopez-Miranda, J; Delgado-Lista, J (通讯作者)，Reina Sofia Univ Hosp, Internal Med Unit, Lipids & Atherosclerosis Unit, Cordoba 14004, Spain.; Lopez-Miranda, J; Delgado-Lista, J (通讯作者)，Maimonides Inst Biomed Res Cordoba IMIBIC, Cordoba 14004, Spain.; Lopez-Miranda, J; Delgado-Lista, J (通讯作者)，Univ Cordoba, Dept Med & Surg Sci, Cordoba 14004, Spain.; Lopez-Miranda, J; Delgado-Lista, J (通讯作者)，Inst Salud Carlos III, CIBER Physiopathol Obes & Nutr, Madrid 28029, Spain. EM bc2cavij@uco.es RI Caballero-Villarraso, Javier/AAC-3434-2019; Pérez Martínez, Pablo/AEL-6176-2022; Arenas de Larriva, Antonio P/Y-9969-2019; Luque, Raul M/M-6948-2018; Alcala-Diaz, Juan Francisco/F-5329-2016; Torres Peña, José D/ABH-3312-2020; Lopez-Miranda, Jose/Y-8306-2019; Delgado-Lista, Javier/KAM-7412-2024; Gutierrez Mariscal, Francisco Miguel/AAX-3185-2021 OI Caballero-Villarraso, Javier/0000-0003-0571-5147; Pérez Martínez, Pablo/0000-0001-7716-8117; Arenas de Larriva, Antonio P/0000-0001-8897-5176; Luque, Raul M/0000-0002-7585-1913; Martin-Piea, Laura/0000-0002-0213-3734; Alcala-Diaz, Juan Francisco/0000-0002-4572-3611; Romero Cabrera, Juan Luis/0000-0001-6459-3536; Torres Peña, José D/0000-0003-1366-5549; Lopez-Miranda, Jose/0000-0002-8844-0718; Gutierrez Mariscal, Francisco Miguel/0000-0003-3353-2188 FU Fundacion Patrimonio Comunal Olivarero (CORDIOPREV-CEAS) [1/2016]; Ministerio de Ciencia e Innovacion [AGL2012-39615, AGL2015-67896-P, PID2019-104362RB-I00]; Instituto de Salud Carlos III (ISCIII) of Spain; Directorate General for Assessment and Promotion of Research; EU's European Regional Development Fund (FEDER); Spanish Government of Investigation, Development and Innovation [SAF2017-84135-R]; FEDER FX The CORDIOPREV study was supported by the Fundacion Patrimonio Comunal Olivarero (CORDIOPREV-CEAS, 1/2016 to Jose Lopez-Miranda). This study also received research grants from the Ministerio de Ciencia e Innovacion (AGL2012-39615, AGL2015-67896-P and PID2019-104362RBI00 to Jose Lopez-Miranda), integrated into the framework of the National Plan for Scientific Research, Technological Development and Innovation 2013-2016, co-financed by the Instituto de Salud Carlos III (ISCIII) of Spain and also by the Directorate General for Assessment and Promotion of Research and the EU's European Regional Development Fund (FEDER). This work has been supported in part by the Spanish Government of Investigation, Development and Innovation (SAF2017-84135-R), including FEDER co-funding. 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Information on specific dietary requirements is necessary to improve the competitiveness of meagre farming. While the essential fatty acids (EFA) requirement of meagre fingerlings was previously estimated, knowledge regarding the EFA requirement of on-growing meagre juveniles is still lacking. To assess the EFA requirement of juvenile meagre, six isolipidic, isoproteic, semi-purified diets with different levels of n-3 long-chain polyunsaturated fatty acid (n-3 LC-PUFA) contents 0.0%, 0.3%, 0.6%, 0.9%, 1.2%, and 1.5% of diet dry matter (DM) were formulated and fed three times daily to triplicate groups of juvenile meagres of 35.6 +/- 0.3 g for twelve weeks. Growth rates, whole body composition and fatty acid profile, liver lipid content as well as fatty acid profiles were assessed. In addition, the incidence of hepatic steatosis and granulomatosis was evaluated. Juvenile meagre fed the 0.0% n-3 LC-PUFA diet showed significantly lower growth and final body weight compared to all other treatments. There was an increase in growth of meagre with increasing dietary n-3 LC-PUFA levels and weight gain plateaued at levels above 0.9% n-3 LC-PUFA. Occurrence of granulomas examined in the liver supported the data on growth as the hepatic granulomatosis incidence in the groups fed <0.9% n-3 LC-PUFA were greater compared to fish fed diets containing higher levels of n-3 LC-PUFA. The findings of this study showed that the dietary n-3 LC-PUFA requirement of juvenile meagre for optimal growth and liver health status lays between 0.7 and 0.8% of the dietary dry matter. C1 [Pfalzgraff, Tilo; Borges, Pedro; Robaina, Lidia; Kaushik, Sadasivam; Izquierdo, Marisol] Univ Las Palmas De Gran Canaria ULPGC, Inst Sustainable Aquaculture & Marine Ecosyst ECOA, Aquaculture Res Grp GIA, Crta Taliarte S-N, Telde 35214, Spain. [Pfalzgraff, Tilo] Tech Univ Denmark, North Sea Res Ctr, Sect Aquaculture, DTU Aqua, DK-9850 Hirtshals, Denmark. [Borges, Pedro] Skretting Aquaculture Res Ctr, POB 48, N-4001 Stavanger, Norway. C3 Universidad de Las Palmas de Gran Canaria; Technical University of Denmark RP Pfalzgraff, T (通讯作者)，Univ Las Palmas De Gran Canaria ULPGC, Inst Sustainable Aquaculture & Marine Ecosyst ECOA, Aquaculture Res Grp GIA, Crta Taliarte S-N, Telde 35214, Spain.; Pfalzgraff, T (通讯作者)，Tech Univ Denmark, North Sea Res Ctr, Sect Aquaculture, DTU Aqua, DK-9850 Hirtshals, Denmark. EM tilpf@aqua.dtu.dk; pedro.borges@skretting.com; lidia.robaina@ulpgc.es; sachi.kaushik@ulpgc.es; marisol.izquierdo@ulpgc.es RI Kaushik, Sadasivam/HTO-8623-2023; Robaina, Lidia/I-2128-2015 OI Kaushik, Sadasivam/0000-0001-7856-8374; Marisol, Izquierdo/0000-0003-4297-210X; Pfalzgraff, Tilo/0000-0001-8059-6534; FU AQUAEXCEL2020 - H2020 programme [TNA AE060028] FX This study was partially supported by AQUAEXCEL2020 (AQUA-culture infrastructures for EXCELlence in European fish research to-wards 2020), funded by H2020 programme, in the frame of Transnational Access - TNA AE060028 (http://aquaexcel2020.eu/). The authors want to thank Alvaro Fern'andez Montero, Miguel 'Angel Ruiz Garcia, Marta Ribeiro Carvalho, Nabil Oubramy Reyes, Rayco David Cruz Perez, Dennis Wittmann, and Hanlin Xu for the help during the sampling. 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Zinman, Bernard TI Glucose Lowering Strategies for Cardiac Benefits: Pathophysiological Mechanisms SO PHYSIOLOGY LA English DT Review ID FATTY LIVER-DISEASE; CLINICAL-PRACTICE GUIDELINES; INTENSIVE GLYCEMIC CONTROL; TYPE-2 DIABETES-MELLITUS; ACTIVATED PROTEIN-KINASE; CORONARY-ARTERY-DISEASE; CARDIOVASCULAR OUTCOMES; FOLLOW-UP; SEVERE HYPOGLYCEMIA; MEDITERRANEAN DIET AB Recent trials in Type 2 diabetes (T2D) have shown cardiovascular benefits with specific GLP-1 receptor agonists and SGLT2 inhibitors. We discuss the landscape of outcome trials in T2D from a pathophysiology viewpoint, review current knowledge gaps in underlying mechanisms, propose a caloric fuel routing hypothesis, and highlight areas of future research. C1 [Bajaj, Harpreet S.] LMC Diabet & Endocrinol, Brampton, ON, Canada. [Bajaj, Harpreet S.; Zinman, Bernard] Mt Sinai Hosp, Leadership Sinai Ctr Diabet, Toronto, ON, Canada. [Zinman, Bernard] Mt Sinai Hosp, Lunenfeld Tanenbaum Res Inst, Toronto, ON, Canada. [Zinman, Bernard] Univ Toronto, Div Endocrinol, Toronto, ON, Canada. C3 University of Toronto; Sinai Health System Toronto; Lunenfeld Tanenbaum Research Institute; University of Toronto; Sinai Health System Toronto; Lunenfeld Tanenbaum Research Institute; University of Toronto RP Bajaj, HS (通讯作者)，LMC Diabet & Endocrinol, Brampton, ON, Canada.; Bajaj, HS (通讯作者)，Mt Sinai Hosp, Leadership Sinai Ctr Diabet, Toronto, ON, Canada. 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S, 2010, NEW ENGL J MED, V363, P1410, DOI 10.1056/NEJMoa1003795 NR 113 TC 5 Z9 5 U1 0 U2 2 PU AMER PHYSIOLOGICAL SOC PI Rockville PA 6120 Executive Blvd, Suite 600, Rockville, MD, UNITED STATES SN 1548-9213 EI 1548-9221 J9 PHYSIOLOGY JI Physiology PD MAY PY 2018 VL 33 IS 3 BP 197 EP 210 DI 10.1152/physiol.00004.2018 PG 14 WC Physiology WE Science Citation Index Expanded (SCI-EXPANDED) SC Physiology GA GP6HT UT WOS:000440980000004 PM 29638185 OA Bronze DA 2026-02-02 ER PT J AU Lemonakis, N Poudyal, H Halabalaki, M Brown, L Tsarbopoulos, A Skaltsounis, AL Gikas, E AF Lemonakis, Nikolaos Poudyal, Hemant Halabalaki, Maria Brown, Lindsay Tsarbopoulos, Anthony Skaltsounis, Alexios-Leandros Gikas, Evagelos TI The LC-MS-based metabolomics of hydroxytyrosol administration in rats reveals amelioration of the metabolic syndrome SO JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES LA English DT Article DE Hydroxytyrosol; Metabolomics; Metabolic pathway analysis; Metabolic syndrome ID OLIVE OIL; MEDITERRANEAN DIET; HUMAN HEALTH; RISK; CHROMATOGRAPHY; METABOANALYST; DEATH; FAT AB Hydroxytyrosol (HT), an important component of olive fruit and olive oil, improves the signs of metabolic syndrome in rats following chronic treatment. At a dose of 20 mg/kg/day, HT decreased adiposity and improved cardiovascular and liver structure and function in rats fed with a high-carbohydrate, high-fat diet. An untargeted metabolomics approach has been employed using both UPLC-Orbitrap and -QqTOF methods to identify the changes induced by chronic HT administration on the plasma metabolome. 31 metabolites have been found to be differentially expressed between the examined groups. HT was shown to decrease biosynthesis of unsaturated fatty acids, fatty acid biosynthesis, and the metabolism of linoleic acid, retinol, sphingolipids and arachidonic acid, whereas glycerolipid metabolism is up-regulated. These are plausible mechanisms for the attenuation by HT of cardiovascular, liver and metabolic changes in high-carbohydrate, high-fat diet fed rats. (C) 2016 Elsevier B.V. All rights reserved. C1 [Lemonakis, Nikolaos; Halabalaki, Maria; Skaltsounis, Alexios-Leandros] Univ Athens, Fac Pharm, Dept Pharmacognosy & Nat Prod Chem, Athens 11527, Greece. [Poudyal, Hemant; Brown, Lindsay] Univ Southern Queensland, Sch Hlth & Wellbeing, Toowoomba, Qld 4350, Australia. [Poudyal, Hemant] Kyoto Univ, Dept Diabet Endocrinol & Nutr, Kyoto, Japan. [Poudyal, Hemant] Kyoto Univ, Hakubi Ctr Adv Res, Kyoto, Japan. [Tsarbopoulos, Anthony] Univ Athens, Sch Med, Dept Pharmacol, Athens 11527, Greece. [Gikas, Evagelos] Univ Athens, Fac Pharm, Dept Pharmaceut Chem, Athens 11527, Greece. C3 National & Kapodistrian University of Athens; University of Southern Queensland; Kyoto University; Kyoto University; National & Kapodistrian University of Athens; National & Kapodistrian University of Athens RP Gikas, E (通讯作者)，Univ Athens, Fac Pharm, Dept Pharmaceut Chem, Athens 15771, Greece. EM vgikas@pharm.uoa.gr RI skaltsounis, alexios/AAE-9617-2019; Poudyal, Hemant/HOH-9324-2023; Gikas, Evagelos/H-6226-2019; Halabalaki, Maria/AAD-2127-2020 FU Grants-in-Aid for Scientific Research [17K15573] Funding Source: KAKEN CR Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644 Andreadou I, 2015, PLANTA MED, V81, P655, DOI 10.1055/s-0034-1383306 Babio N, 2009, PUBLIC HEALTH NUTR, V12, P1607, DOI 10.1017/S1368980009990449 Barbaro B, 2014, INT J MOL SCI, V15, P18508, DOI 10.3390/ijms151018508 Berg J.M., 2002, Triacylglycerols Are Highly Concentrated Energy Stores, Vfifth Brown L, 2015, OBES REV, V16, P914, DOI 10.1111/obr.12313 Brozinick JT, 2013, INT J OBESITY, V37, P1064, DOI 10.1038/ijo.2012.191 Cabrerizo S, 2013, J NUTR BIOCHEM, V24, P2152, DOI 10.1016/j.jnutbio.2013.08.007 Cao K, 2014, FREE RADICAL BIO MED, V67, P396, DOI 10.1016/j.freeradbiomed.2013.11.029 Cicerale S, 2009, CRIT REV FOOD SCI, V49, P218, DOI 10.1080/10408390701856223 Covas MI, 2015, BRIT J NUTR, V113, pS19, DOI 10.1017/S0007114515000136 Dunn WB, 2011, NAT PROTOC, V6, P1060, DOI 10.1038/nprot.2011.335 Efentakis P, 2015, PLANTA MED, V81, P648, DOI 10.1055/s-0035-1546017 Ford ES, 2008, DIABETES CARE, V31, P1898, DOI 10.2337/dc08-0423 Gami AS, 2007, J AM COLL CARDIOL, V49, P403, DOI 10.1016/j.jacc.2006.09.032 Grundy SM, 2006, CURR OPIN CARDIOL, V21, P1, DOI 10.1097/01.hco.0000200416.65370.a0 Jemai H, 2009, J AGR FOOD CHEM, V57, P8798, DOI 10.1021/jf901280r KEYS A, 1986, AM J EPIDEMIOL, V124, P903, DOI 10.1093/oxfordjournals.aje.a114480 Larsson O, 2005, BMC BIOINFORMATICS, V6, DOI 10.1186/1471-2105-6-129 López-Miranda J, 2010, NUTR METAB CARDIOVAS, V20, P284, DOI 10.1016/j.numecd.2009.12.007 Mastralexi A, 2014, J AGR FOOD CHEM, V62, P2459, DOI 10.1021/jf5005918 Panagiotakos DB, 2004, MED SCI MONITOR, V10, pRA193 Park YW, 2003, ARCH INTERN MED, V163, P427, DOI 10.1001/archinte.163.4.427 Pérez-Jiménez F, 2007, MOL NUTR FOOD RES, V51, P1199, DOI 10.1002/mnfr.200790023 Poudyal H., PHARMACOL META UNPUB Poudyal H, 2010, J NUTR, V140, P946, DOI 10.3945/jn.109.117812 Rafehi Haloom, 2012, Journal of Dietary Supplements, V9, P96, DOI 10.3109/19390211.2012.682644 Rhee EJ, 2012, DIABETES METAB J, V36, P167 Ristagno G, 2012, J AGR FOOD CHEM, V60, P5859, DOI 10.1021/jf2049323 Santos-Buelga C, 2012, ARCH BIOCHEM BIOPHYS, V527, P65, DOI 10.1016/j.abb.2012.08.012 Snyder NW, 2013, JOVE-J VIS EXP, DOI 10.3791/50433 van den Berg RA, 2006, BMC GENOMICS, V7, DOI 10.1186/1471-2164-7-142 Vázquez-Velasco M, 2011, BRIT J NUTR, V105, P1448, DOI 10.1017/S0007114510005015 Visioli F, 2011, CURR PHARM DESIGN, V17, P786, DOI 10.2174/138161211795428885 Wang X., 2013, LIVER INT Westerhuis JA, 2008, METABOLOMICS, V4, P81, DOI 10.1007/s11306-007-0099-6 Xia J., 2011, Curr Protoc Bioinformatics, DOI [10.1002/0471250953.bi1410s34, DOI 10.1002/0471250953.BI1410S34] Xia JG, 2012, NUCLEIC ACIDS RES, V40, pW127, DOI 10.1093/nar/gks374 Xia JG, 2011, NAT PROTOC, V6, P743, DOI 10.1038/nprot.2011.319 Xia JG, 2010, BIOINFORMATICS, V26, P2342, DOI 10.1093/bioinformatics/btq418 Xia JG, 2009, NUCLEIC ACIDS RES, V37, pW652, DOI 10.1093/nar/gkp356 Xynos N, 2015, PLANTA MED, V81, P1621, DOI 10.1055/s-0035-1558111 Yuyama K, 2014, BBA-MOL CELL BIOL L, V1841, P793, DOI 10.1016/j.bbalip.2013.08.002 NR 43 TC 30 Z9 34 U1 1 U2 37 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 1570-0232 EI 1873-376X J9 J CHROMATOGR B JI J. Chromatogr. B PD JAN 15 PY 2017 VL 1041 BP 45 EP 59 DI 10.1016/j.jchromb.2016.12.020 PG 15 WC Biochemical Research Methods; Chemistry, Analytical WE Science Citation Index Expanded (SCI-EXPANDED) SC Biochemistry & Molecular Biology; Chemistry GA EI8TR UT WOS:000392781500006 PM 28012379 DA 2026-02-02 ER PT J AU Monge-Ortiz, R Tomás-Vidal, A Rodriguez-Barreto, D Martínez-Llorens, S Pérez, JA Jover-Cerdá, M Lorenzo, A AF Monge-Ortiz, R. Tomas-Vidal, A. Rodriguez-Barreto, D. Martinez-Llorens, S. Perez, J. A. Jover-Cerda, M. Lorenzo, A. TI Replacement of fish oil with vegetable oil blends in feeds for greater amberjack (Seriola dumerili) juveniles: Effect on growth performance, feed efficiency, tissue fatty acid composition and flesh nutritional value SO AQUACULTURE NUTRITION LA English DT Article DE alternative oil sources; fatty acid composition; fish oil substitution; greater amberjack; linseed oil; palm oil ID SALMON SALMO-SALAR; BREAM SPARUS-AURATA; BASS DICENTRARCHUS-LABRAX; EUROPEAN SEA-BASS; PLANT PROTEIN-SOURCES; PRACTICAL DIETS; LIPID SOURCES; RAPESEED OIL; CANOLA OIL; MEDITERRANEAN YELLOWTAIL AB This study was undertaken to assess the effects of fish oil (FO) substitution by a mixture of alternative vegetable oils (VO) on Seriola dumerili culture performance. A 154-day feeding experiment was conducted using juveniles (39.2 +/- 1.6g average weight). Three isolipidic and isoenergetic meal-based diets were formulated varying their lipid component. The control diet contained 100% FO (FO100), whereas diets VO50 and VO100 included 1/2 of oil blend and all the oil from blend of palm oil (PO) and linseed oil (LO) as substitute for FO, respectively. Dietary regime did not significantly affect growth performance, biometric indices, feed efficiency, plasma chemistry and liver and muscle lipid contents. Nonetheless, dietary VO inclusion impacted on the fatty acid profile of target tissues, especially in the liver. Fatty acid profiles of the fillets reflected those of the dietary oils except that there was apparent selective utilization of palmitic acid (C16:0) and oleic acid (C18:1n-9) and apparent selective retention of long-chain polyunsaturated fatty acids, especially eicosapentaenoic acid (EPA, C20:5n-3) and docosahexaenoic acid (DHA, C22:6n-3). The nutritional value and the potential ability to prevent the development of coronary heart diseases of the flesh lipid fraction decreased with gradual FO substitution. C1 [Monge-Ortiz, R.; Tomas-Vidal, A.; Martinez-Llorens, S.; Jover-Cerda, M.] Univ Politecn Valencia, Inst Anim Sci & Technol, Res Grp Aquaculture & Biodivers, Valencia, Spain. [Rodriguez-Barreto, D.; Perez, J. A.; Lorenzo, A.] Univ La Laguna, Dept Biol Anim Edafologia Geologia Fisiologia Fac, Fac Ciencias, Secc Biol,Dept Biol Anim Edafol & Geol UDI Fisiol, San Cristobal De La Lagu, Spain. C3 Universitat Politecnica de Valencia; Universidad de la Laguna RP Monge-Ortiz, R (通讯作者)，Univ Politecn Valencia, Inst Anim Sci & Technol, Valencia, Spain. 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Nutr. PD FEB PY 2018 VL 24 IS 1 BP 605 EP 615 DI 10.1111/anu.12595 PG 11 WC Fisheries WE Science Citation Index Expanded (SCI-EXPANDED) SC Fisheries GA FS8MR UT WOS:000422666900063 OA Green Submitted, Bronze DA 2026-02-02 ER PT J AU Fan, Y Liu, YH Shao, CY Jiang, CY Wu, LJ Xiao, J Tang, L AF Fan, Yue Liu, Yinhui Shao, Chenyi Jiang, Chunyu Wu, Lijuan Xiao, Jing Tang, Li TI Gut Microbiota-Targeted Therapeutics for Metabolic Disorders: Mechanistic Insights into the Synergy of Probiotic-Fermented Herbal Bioactives SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES LA English DT Review DE gut microbiota; metabolic diseases; traditional Chinese medicine; probiotics; fermentation ID FATTY LIVER-DISEASE; CALORIE RESTRICTION; MEDITERRANEAN DIET; OBESITY; ALTERS; ACIDS AB Gut microbiota dysbiosis is intricately linked to metabolic disorders such as obesity, type 2 diabetes mellitus (T2DM), hyperlipidemia, and non-alcoholic fatty liver disease (NAFLD). Traditional Chinese medicine (TCM), particularly when combined with probiotic fermentation, offers a promising therapeutic strategy by modulating microbial balance and host metabolism. This narrative review synthesizes current research on probiotic-fermented herbal bioactives, focusing on their mechanisms in ameliorating metabolic diseases. Probiotic and bioactive compounds (e.g., berberine, polysaccharides) are highlighted for their roles in enhancing intestinal barrier function, regulating microbial metabolites like short-chain fatty acids (SCFAs), and reducing inflammation. Fermentation techniques improve the bioavailability of TCM components while reducing toxicity, as seen in fermented Salvia miltiorrhiza and Rhizoma Coptidis. Despite promising results, challenges include the complexity of microbiota-host interactions and variability in TCM standardization. Future directions emphasize integrating multi-omics technologies and personalized approaches to optimize probiotic-fermented TCM therapies. This review underscores the potential of combining traditional herbal wisdom with modern biotechnology to address metabolic disorders, which pose significant global health challenges, through a "gut microbiota-metabolism" axis. Emerging evidence highlights the critical role of gut microbiota dysbiosis in the pathogenesis of these conditions. TCM has shown promise in modulating gut microbiota to restore metabolic homeostasis. This review synthesizes current research on TCM-derived interventions, such as herbal compounds, probiotics, and fermentation techniques, that target gut microbiota to ameliorate metabolic disorders. We discuss mechanisms of action, including prebiotic effects, enhancement of intestinal barrier function, and regulation of microbial metabolites, while addressing the limitations and future directions of TCM-based therapies. C1 [Fan, Yue; Liu, Yinhui; Shao, Chenyi; Jiang, Chunyu; Wu, Lijuan; Tang, Li] Dalian Med Univ, Coll Basic Med Sci, Dept Microecol, Dalian 116041, Peoples R China. [Xiao, Jing] Dalian Med Univ, Coll Stomatol, Dept Oral Pathol, Dalian 116041, Peoples R China. C3 Dalian Medical University; Dalian Medical University RP Tang, L (通讯作者)，Dalian Med Univ, Coll Basic Med Sci, Dept Microecol, Dalian 116041, Peoples R China.; Xiao, J (通讯作者)，Dalian Med Univ, Coll Stomatol, Dept Oral Pathol, Dalian 116041, Peoples R China. EM yfan_0220@163.com; yhliu_dl@163.com; shaocy@dmu.edu.cn; 19861558290@163.com; wulijuan939@126.com; xiaoj@dmu.edu.cn; tangl@dmu.edu.cn RI fan, yuexin/LXW-5033-2024; Shao, Chenyi/MHR-1330-2025 OI , yinhui/0000-0001-8985-6769; Tang, Li/0000-0001-9553-5611; FU Dalian Medical University Interdisciplinary Research Cooperation Project Team [JCHZ2023003]; Dalian Medical University Interdisciplinary Research Cooperation Project Team Funding FX Dalian Medical University Interdisciplinary Research Cooperation Project Team Funding (JCHZ2023003). 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PD JUN 7 PY 2025 VL 26 IS 12 AR 5486 DI 10.3390/ijms26125486 PG 39 WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary WE Science Citation Index Expanded (SCI-EXPANDED) SC Biochemistry & Molecular Biology; Chemistry GA 4ED7N UT WOS:001515872500001 PM 40564947 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Guitart, R Guerrero, X Silvestre, AM Gutierrez, JM Mateo, R AF Guitart, R Guerrero, X Silvestre, AM Gutierrez, JM Mateo, R TI Organochlorine residues in tissues of striped dolphins affected by the 1990 Mediterranean epizootic: Relationships with the fatty acid composition SO ARCHIVES OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY LA English DT Article ID POLYCHLORINATED-BIPHENYLS; GAS-CHROMATOGRAPHY; EXTRACTION; LIVER; PCBS AB A simple and rapid method was developed for the simultaneous determination of fatty acids, organochlorine pesticides, and polychlorinated biphenyl (PCB) congeners in the same sample in order to explore possible connections between levels of contaminants and fatty acid composition. The method was applied to samples of melon, cerebrum, cerebellum, lung, liver, kidneys, and skeletal muscle obtained from 5 male and 5 female striped dolphins (Stenella coeruleoalba) found stranded in 1990 in the northeastern Spanish coasts during the morbillivirus epizootic that affected this cetacean in the Mediterranean Sea. The results indicate that PCBs were dominant in all tissues, with the highest geometric mean concentration being found in melon (903 mu g g(-1) wet wt); Sigma DDTs were also found at high concentrations (111 mu g g(-1) wet wt, in melon). Statistical analysis indicate that organochlorine concentration was correlated with the fatty acid composition of tissues, although some of these variations can be interpreted as a consequence of a shift in the diet produced in the striped dolphin population. 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PD JAN PY 1996 VL 30 IS 1 BP 79 EP 83 PG 5 WC Environmental Sciences; Toxicology WE Science Citation Index Expanded (SCI-EXPANDED) SC Environmental Sciences & Ecology; Toxicology GA TH793 UT WOS:A1996TH79300010 PM 8579385 DA 2026-02-02 ER PT J AU Kaikkonen, JE Mikkilä, V Raitakari, OT AF Kaikkonen, Jari E. Mikkila, Vera Raitakari, Olli T. TI Role of Childhood Food Patterns on Adult Cardiovascular Disease Risk SO CURRENT ATHEROSCLEROSIS REPORTS LA English DT Article DE Adulthood; Cardiovascular disease; Childhood; Dietary patterns; Macronutrients; Nutrition; Tracking ID MEDITERRANEAN DIETARY PATTERN; FACTOR INTERVENTION PROJECT; INFANCY-ONSET DIETARY; FATTY LIVER-DISEASE; BODY-MASS INDEX; LIFE-STYLE; VEGETABLE CONSUMPTION; COHORT PROFILE; YOUNG-ADULTS; INCREASED ADIPOSITY AB Accumulating evidence indicates that childhood nutrition plays a role in the adulthood cardiovascular health. A lifelong tracking of dietary habits, following a long-term exposure to unhealthy dietary patterns or independent effects, is a potential effect-mediating mechanism. Dietary patterns have been studied by data-driven and hypothesis-based approaches. Typically, either data-driven healthy or prudent childhood dietary patterns have been characterized and found to be associated with lower adulthood cardiovascular disease (CVD) risk in the published cohort studies. With regard to the individual food groups or food quality indices, intakes particularly of vegetables and fruits (or fiber indicating plant food intake) and polyunsaturated fatty acids have shown protective effects. The evidence which could confirm the long-term healthiness of a hypothesis-based Mediterranean diet is limited, requiring further investigation. Overall, the recent literature strengthens the view that a healthy childhood diet is associated with lowered adulthood CVD risk. 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Atheroscleros. Rep. PD OCT PY 2014 VL 16 IS 10 AR 443 DI 10.1007/s11883-014-0443-z PG 15 WC Peripheral Vascular Disease WE Science Citation Index Expanded (SCI-EXPANDED) SC Cardiovascular System & Cardiology GA AO9TB UT WOS:000341698700003 PM 25092579 DA 2026-02-02 ER PT J AU Stephenson, JA Al-Taan, O Arshad, A West, AL Calder, PC Morgan, B Metcalfe, MS Dennison, AR AF Stephenson, James A. Al-Taan, Omer Arshad, Ali West, Annette L. Calder, Philip C. Morgan, Bruno Metcalfe, Matthew S. Dennison, Ashley R. TI Unsaturated fatty acids differ between hepatic colorectal metastases and liver tissue without tumour in humans: Results from a randomised controlled trial of intravenous eicosapentaenoic and docosahexaenoic acids SO PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS LA English DT Article DE n-3 PUFA; Fish oil; Cancer; Liver tissue composition; Tumour composition ID OLIVE OIL; MEDITERRANEAN DIET; ARACHIDONIC-ACID; OLEIC-ACID; TRASTUZUMAB HERCEPTIN(TM); COLON CARCINOGENESIS; CELL-PROLIFERATION; CANCER-CELLS; BREAST; MEMBRANE AB Introduction: Mediators derived from the n-6 polyunsaturated fatty acid (PUFA) arachidonic acid oxidation have been shown to have tumour promoting effects in experimental models, while n-3 PUFAs are thought to be protective. Here we report fatty acid concentrations in hepatic colorectal metastases compared to liver tissue without tumour in humans. Methods: Twenty patients with colorectal liver metastasis were randomized to receive a 72 h infusion of parenteral nutrition with or without n-3 PUFAs. Histological samples from liver metastases and liver tissue without tumour were obtained from 15 patients at the time of their subsequent liver resection (mean 8 days (range 4-12) post-infusion) and the fatty acid composition determined by gas chromatography. Results: There were no significant differences in fatty acid composition between the two intervention groups. When data from all patients were combined, liver tissue without tumour had a higher content of both n-3 and n-6 PUFAs and a lower content of oleic acid and total n-9 fatty acids compared with tumour tissue (p < 0.0001, 0.0002, < 0.0001 and < 0.0001, respectively). The n-6/n-3 PUFA ratio was found to be higher in tumour tissue than tissue without tumour (p < 0.0001). Conclusions: Hepatic colorectal adenocarcinoma metastases have a higher content of n-9 fatty acids and a lower content of n-6 and n-3 PUFAs than liver tissue without tumour. (c) 2013 Elsevier Ltd. All rights reserved. C1 [Stephenson, James A.; Morgan, Bruno] Univ Hosp Leicester NHS Trust, Dept Imaging, Leicester LE5 4PW, Leics, England. [Al-Taan, Omer; Arshad, Ali; Metcalfe, Matthew S.; Dennison, Ashley R.] Univ Hosp Leicester NHS Trust, Dept Hepatobiliary & Pancreat Surg, Leicester LE5 4PW, Leics, England. [West, Annette L.; Calder, Philip C.] Univ Southampton, Southampton Gen Hosp, Fac Med, Human Dev & Hlth Acad Unit, Southampton SO16 6YD, Hants, England. [Calder, Philip C.] Univ Southampton, Southampton Biomed Res Ctr, Natl Inst Hlth Res, Southampton SO16 6YD, Hants, England. [Calder, Philip C.] Univ Hosp Southampton NHS Fdn Trust, Southampton SO16 6YD, Hants, England. C3 University Hospitals of Leicester NHS Trust; University of Leicester; University Hospitals of Leicester NHS Trust; University of Leicester; University of Southampton; University of Southampton; University of Southampton; University Hospital Southampton NHS Foundation Trust RP Stephenson, JA (通讯作者)，Univ Hosp Leicester NHS Trust, Dept Imaging, Gwendolen Rd, Leicester LE5 4PW, Leics, England. EM jastephenson@doctors.org.uk RI ; Calder, Philip/E-9739-2013; ALI, MD ARSHAD/ADT-9829-2022 OI Dennison, Ashley/0000-0003-0090-503X; West, Annette/0000-0002-3331-0684; Calder, Philip/0000-0002-6038-710X; Morgan, Bruno/0000-0001-9708-675X; FU B. Braun Melsungen, Germany; B. Braun Melsungen; Fresenius Kabi; Baxter Healthcare; Abbott Nutrition; Nestle; B. Braun FX The study was partly funded by an educational grant for research from B. Braun Melsungen, Germany. ARD, MSM, JS, OAT and CP have received educational travelling grants from B. Braun Melsungen. PCC has received speaking fees from B. Braun Melsungen, Fresenius Kabi, Baxter Healthcare, Abbott Nutrition, and Nestle and has received research funding from B. Braun. 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Essent. Fatty Acids PD JUN PY 2013 VL 88 IS 6 BP 405 EP 410 DI 10.1016/j.plefa.2013.04.002 PG 6 WC Biochemistry & Molecular Biology; Cell Biology; Endocrinology & Metabolism WE Science Citation Index Expanded (SCI-EXPANDED) SC Biochemistry & Molecular Biology; Cell Biology; Endocrinology & Metabolism GA 160UD UT WOS:000320145100001 PM 23647811 DA 2026-02-02 ER PT J AU Stadler, JT Marsche, G AF Stadler, Julia T. Marsche, Gunther TI Dietary Strategies to Improve Cardiovascular Health: Focus on Increasing High-Density Lipoprotein Functionality SO FRONTIERS IN NUTRITION LA English DT Review DE Mediterranean diet; polyphenols; HDL composition; paraoxonase1; cholesterol efflux capacity ID ESTER TRANSFER PROTEIN; FATTY LIVER-DISEASE; APOLIPOPROTEIN-A-I; LECITHIN-CHOLESTEROL ACYLTRANSFERASE; SERUM PARAOXONASE ACTIVITY; ALTERS HDL COMPOSITION; C-REACTIVE PROTEIN; LIFE-STYLE CHANGES; VIRGIN OLIVE OIL; EICOSAPENTAENOIC ACID AB Cardiovascular disease is one of the leading causes of morbidity and mortality worldwide, with increasing incidence. A cornerstone of cardiovascular disease prevention is lifestyle modification through dietary changes to influence various risk factors such as obesity, hypertension and diabetes. The effects of diet on cardiovascular health are complex. Some dietary components and metabolites directly affect the composition and structure of high-density lipoproteins (HDL) and increase anti-inflammatory and vasoprotective properties. HDLs are composed of distinct subpopulations of particles of varying size and composition that have several dynamic and context-dependent functions. The identification of potential dietary components that improve HDL functionality is currently an important research goal. One of the best-studied diets for cardiovascular health is the Mediterranean diet, consisting of fish, olive oil, fruits, vegetables, whole grains, legumes/nuts, and moderate consumption of alcohol, most commonly red wine. The Mediterranean diet, especially when supplemented with extra virgin olive oil rich in phenolic compounds, has been shown to markedly improve metrics of HDL functionality and reduce the burden, or even prevent the development of cardiovascular disease. Particularly, the phenolic compounds of extra virgin olive oil seem to exert the significant positive effects on HDL function. Moreover, supplementation of anthocyanins as well as antioxidants such as lycopene or the omega-3 fatty acid eicosapentaenoic acid improve parameters of HDL function. In this review, we aim to highlight recent discoveries on beneficial dietary patterns as well as nutritional components and their effects on cardiovascular health, focusing on HDL function. C1 [Stadler, Julia T.; Marsche, Gunther] Med Univ Graz, Otto Loewi Res Ctr, Div Pharmacol, Graz, Austria. C3 Medical University of Graz RP Stadler, JT; Marsche, G (通讯作者)，Med Univ Graz, Otto Loewi Res Ctr, Div Pharmacol, Graz, Austria. EM julia.stadler@medunigraz.at; gunther.marsche@medunigraz.at OI Stadler, Julia/0000-0003-1156-631X FU Austrian Science Fund (FWF) [DOC 31-B26]; Medical University Graz [DP iDP] FX Funding This work was supported by the Austrian Science Fund (FWF) (DOC 31-B26) and the Medical University Graz through the PhD Program Inflammatory Disorders in Pregnancy (DP iDP). 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Nutr. PD NOV 22 PY 2021 VL 8 AR 761170 DI 10.3389/fnut.2021.761170 PG 16 WC Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Nutrition & Dietetics GA YH1VB UT WOS:000742960900001 PM 34881279 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Srnic, N Westcott, F Caney, E Hodson, L AF Srnic, Nikola Westcott, Felix Caney, Eleanor Hodson, Leanne TI Dietary fat quantity and composition influence hepatic lipid metabolism and metabolic disease risk in humans SO DISEASE MODELS & MECHANISMS LA English DT Review DE Dietary fat; Fat metabolism; Hepatocyte; Lipid droplet; Liver ID INSULIN-RESISTANCE; LIVER FAT; SATURATED FAT; PALMITIC ACID; MEDITERRANEAN DIET; LOW-CARBOHYDRATE; ADIPOSE-TISSUE; GLYCEMIC INDEX; RAT-LIVER; ACCUMULATION AB The excessive accumulation of intrahepatic triglyceride (IHTG) in the liver is a risk factor for metabolic diseases, including type 2 diabetes and cardiovascular disease. IHTG can excessively accumulate owing to imbalances in the delivery, synthesis, storage and disposal of fat to, in and from the liver. Although obesity is strongly associated with IHTG accumulation, emerging evidence suggests that the composition of dietary fat, in addition to its quantity, plays a role in mediating IHTG accumulation. Evidence from human cross-sectional and interventional studies indicates that diets enriched with saturated fat compared to other fat types and carbohydrates produce divergent effects on IHTG content. However, the mechanistic reasons for these observations remain unknown. Given the challenges of investigating such mechanisms in humans, cellular models are needed that can recapitulate human hepatocyte fatty acid metabolism. Here, we review what is known from human studies about how dietary fat, its quantity and composition contribute to IHTG accumulation. We also explore the effects of fatty acid composition on hepatocellular fat metabolism from data generated in cellular models to help explain the divergences observed in in vivo studies. C1 [Srnic, Nikola; Westcott, Felix; Caney, Eleanor; Hodson, Leanne] Univ Oxford, Oxford Ctr Diabet Endocrinol & Metab, Oxford OX3 7LE, England. [Hodson, Leanne] Churchill Hosp, Oxford NIHR Biomed Res Ctr, Oxford OX3 7LE, England. C3 University of Oxford; University of Oxford RP Hodson, L (通讯作者)，Univ Oxford, Oxford Ctr Diabet Endocrinol & Metab, Oxford OX3 7LE, England.; Hodson, L (通讯作者)，Churchill Hosp, Oxford NIHR Biomed Res Ctr, Oxford OX3 7LE, England. EM leanne.hodson@ocdem.ox.ac.uk OI Westcott, Felix/0000-0002-5315-7963; Srnic, Nikola/0000-0003-0539-7046; Hodson, Leanne/0000-0002-2648-6526 FU Oxford MB PhD Programme of the Kennedy Trust for Rheumatology Research FX L.H. is supported by a British Heart Foundation (BHF) Senior Research Fellowship (FS/SBSRF/21/31013) ; N.S. is supported by the BHF Oxford 1st intake - The McKie McLean Class of 2021 and the BHF 4-Year PhD Studentship (5th) Scheme; and F.W. was supported by the Oxford MB PhD Programme of the Kennedy Trust for Rheumatology Research.r F.W. was supported by the Oxford MB PhD Programme of the Kennedy Trust for Rheumatology Research. 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Model. Mech. PD JAN PY 2025 VL 18 IS 1 AR dmm050878 DI 10.1242/dmm.050878 PG 12 WC Cell Biology; Medicine, Research & Experimental; Pathology WE Science Citation Index Expanded (SCI-EXPANDED) SC Cell Biology; Research & Experimental Medicine; Pathology GA X4O6J UT WOS:001425165800003 PM 39878508 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Nicoletti, A Ponziani, FR Biolato, M Valenza, V Marrone, G Sganga, G Gasbarrini, A Miele, L Grieco, A AF Nicoletti, Alberto Ponziani, Francesca Romana Biolato, Marco Valenza, Venanzio Marrone, Giuseppe Sganga, Gabriele Gasbarrini, Antonio Miele, Luca Grieco, Antonio TI Intestinal permeability in the pathogenesis of liver damage: From non-alcoholic fatty liver disease to liver transplantation SO WORLD JOURNAL OF GASTROENTEROLOGY LA English DT Review DE Bacterial translocation; Gut microbiota; Gut-liver axis; Liver disease; Cirrhosis; Mediterranean diet; Personalized medicine ID LIPOPOLYSACCHARIDE-BINDING PROTEIN; SPONTANEOUS BACTERIAL PERITONITIS; JUNCTIONAL ADHESION MOLECULE; MESENTERIC LYMPH-NODES; GUT MICROBIOTA; HEPATIC-INJURY; TIGHT JUNCTION; OXIDATIVE STRESS; PORTAL-HYPERTENSION; BARRIER FUNCTION AB The intimate connection and the strict mutual cooperation between the gut and the liver realizes a functional entity called gut-liver axis. The integrity of intestinal barrier is crucial for the maintenance of liver homeostasis. In this mutual relationship, the liver acts as a second firewall towards potentially harmful substances translocated from the gut, and is, in turn, is implicated in the regulation of the barrier. Increasing evidence has highlighted the relevance of increased intestinal permeability and consequent bacterial translocation in the development of liver damage. In particular, in patients with non-alcoholic fatty liver disease recent hypotheses are considering intestinal permeability impairment, diet and gut dysbiosis as the primary pathogenic trigger. In advanced liver disease, intestinal permeability is enhanced by portal hypertension. The clinical consequence is an increased bacterial translocation that further worsens liver damage. Furthermore, this pathogenic mechanism is implicated in most of liver cirrhosis complications, such as spontaneous bacterial peritonitis, hepatorenal syndrome, portal vein thrombosis, hepatic encephalopathy, and hepatocellular carcinoma. After liver transplantation, the decrease in portal pressure should determine beneficial effects on the gut-liver axis, although are incompletely understood data on the modifications of the intestinal permeability and gut microbiota composition are still lacking. How the modulation of the intestinal permeability could prevent the initiation and progression of liver disease is still an uncovered area, which deserves further attention. C1 [Nicoletti, Alberto; Ponziani, Francesca Romana; Biolato, Marco; Valenza, Venanzio; Marrone, Giuseppe; Sganga, Gabriele; Gasbarrini, Antonio; Miele, Luca; Grieco, Antonio] Fdn Policlin Univ A Gemelli IRCCS, I-00168 Rome, Italy. [Nicoletti, Alberto; Ponziani, Francesca Romana; Biolato, Marco; Valenza, Venanzio; Marrone, Giuseppe; Sganga, Gabriele; Gasbarrini, Antonio; Miele, Luca; Grieco, Antonio] Univ Cattolica Sacro Cuore, I-00168 Rome, Italy. C3 Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli; Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli RP Grieco, A (通讯作者)，Fdn Policlin Univ A Gemelli IRCCS, I-00168 Rome, Italy.; Grieco, A (通讯作者)，Univ Cattolica Sacro Cuore, Fdn Policlin Univ A Gemelli IRCCS, Inst Internal Med, Liver Transplant Med Unit, Largo Agostino Gemelli 8, I-00168 Rome, Italy. EM antonio.grieco@unicatt.it RI BIOLATO, Marco/AAC-6691-2022; Ponziani, Francesca Romana/E-4136-2016; Marrone, Giuseppe/AAK-9105-2020; Miele, Luca/C-2255-2015; Gasbarrini, Antonio/AAB-8487-2019; Nicoletti, Alberto/KXQ-6237-2024; Gasbarrini, Antonio/AAB-8487-2019 OI BIOLATO, Marco/0000-0002-5172-8208; Marrone, Giuseppe/0000-0002-9475-3948; Miele, Luca/0000-0003-3464-0068; Gasbarrini, Antonio/0000-0003-4863-6924; Nicoletti, Alberto/0000-0003-0658-4310; Gasbarrini, Antonio/0000-0002-6230-1779 CR Albillos A, 2003, HEPATOLOGY, V37, P208, DOI 10.1053/jhep.2003.50038 Albillos A, 2014, J HEPATOL, V61, P1385, DOI 10.1016/j.jhep.2014.08.010 Alex S, 2013, MOL CELL BIOL, V33, P1303, DOI 10.1128/MCB.00858-12 Amasheh S, 2002, J CELL SCI, V115, P4969, DOI 10.1242/jcs.00165 Amer Assoc Study Liver Dis, 2014, J HEPATOL, V61, P642, DOI 10.1016/j.jhep.2014.05.042 Anderson JM, 2009, CSH PERSPECT BIOL, V1, DOI 10.1101/cshperspect.a002584 Arslan G, 2001, NUCL MED COMMUN, V22, P997, DOI 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Gastroenterol. PD SEP 7 PY 2019 VL 25 IS 33 BP 4814 EP 4834 DI 10.3748/wjg.v25.i33.4814 PG 21 WC Gastroenterology & Hepatology WE Science Citation Index Expanded (SCI-EXPANDED) SC Gastroenterology & Hepatology GA IW1VY UT WOS:000484759900003 PM 31543676 DA 2026-02-02 ER PT J AU Djohan, YF Badia, E Bonafos, B Fouret, G Lauret, C Dupuy, AM Pinot, E Sutra, T Gaillet, S Lambert, K Raynaud, F Gayrard, N Jover, B Monde, AA Cristol, JP Coudray, C Feillet-Coudray, C AF Djohan, Youzan Ferdinand Badia, Eric Bonafos, Beatrice Fouret, Gilles Lauret, Celine Dupuy, Anne-Marie Pinot, Edith Sutra, Thibault Gaillet, Sylvie Lambert, Karen Raynaud, Fabrice Gayrard, Nathalie Jover, Bernard Monde, Absalome Ake Cristol, Jean Paul Coudray, Charles Feillet-Coudray, Christine TI High dietary intake of palm oils compromises glucose tolerance whereas high dietary intake of olive oil compromises liver lipid metabolism and integrity SO EUROPEAN JOURNAL OF NUTRITION LA English DT Article DE Palm oil; Olive oil; High fat intake; Liver steatosis; Oxidative stress ID FATTY LIVER; HEPATIC STEATOSIS; MEDITERRANEAN DIET; OXIDATIVE STRESS; PPAR-ALPHA; MODULATION; RATS; INFLAMMATION; METAANALYSIS; CHOLESTEROL AB PurposePalm (PO) and olive oils (OO) are the two most consumed and/or used oils in the world for food elaboration. These oils should not be confused with the solid palm stearin which is widely used in pastry making. Large number of studies was reported dealing with adverse/beneficial cardiovascular effects of PO and OO, whereas few studies were conducted to compare their potential effects on hepatic steatosis and liver lipid metabolism. The aim of this study was to compare the metabolic effects of high intake of POs (both crude and refined) and virgin OO on surrogate parameters of glucose tolerance, hepatic lipid metabolism and liver integrity.MethodsThirty-two young male Wistar rats were divided into four equal groups and fed either control diet (11% energy from fat) or three high-fat diets rich in crude or refined POs or in OO (56% energy from fat), during 12 weeks. Systemic blood and liver biochemical parameters linked to glucose and lipid metabolism as well as hepatic steatosis and liver fatty acid composition were explored. The inflammation and oxidative stress status as well as the expression of several genes/proteins were also analyzed.ResultsThe major effects of POs intake concerned glucose metabolism and liver fatty acid composition, whereas the major effects of OO intake concerned hepatic TG accumulation, inflammation, and cytolysis.ConclusionsIn conclusion, high dietary intake of PO compromises glucose tolerance whereas high dietary intake of OO compromises hepatic lipid composition and liver integrity. However, adverse hepatic effects of OO observed in this study may not be transposed to human since, (a) the rodent model could lead to different effects than those observed in humans and (b) the average normal OO amounts ingested in the population are lower than those corresponding to a high-fat diet. So, further studies are needed to determine a maximum non-invasive dietary intake of OO. C1 [Djohan, Youzan Ferdinand; Badia, Eric; Lauret, Celine; Lambert, Karen; Raynaud, Fabrice; Jover, Bernard] Univ Montpellier, PhyMedExp, INSERM, U1046,CNRS,UMR 9214, Montpellier, France. [Bonafos, Beatrice; Fouret, Gilles; Gaillet, Sylvie; Coudray, Charles; Feillet-Coudray, Christine] Univ Montpellier, INRA, DMEM, Montpellier, France. [Dupuy, Anne-Marie; Pinot, Edith; Sutra, Thibault; Cristol, Jean Paul] CHU Lapeyronie, Lab Biochim, Montpellier, France. [Gayrard, Nathalie] Univ Montpellier, EA7288, Montpellier, France. [Monde, Absalome Ake] Univ Felix Houphouet Boigny, CHU, Lab Biochim, Cocody, Cote Ivoire. C3 Institut National de la Sante et de la Recherche Medicale (Inserm); Universite de Montpellier; Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Biology (INSB); Universite de Montpellier; INRAE; Universite de Montpellier; CHU de Montpellier; Universite de Montpellier; Universite Felix Houphouet-Boigny RP Badia, E (通讯作者)，Univ Montpellier, PhyMedExp, INSERM, U1046,CNRS,UMR 9214, Montpellier, France. EM eric.badia@umontpellier.fr RI ; Gayrard, Nathalie/AAO-2888-2020; COUDRAY, Charles/AGG-4757-2022; Lambert, Karen/MJQ-7172-2025 OI JOVER, Bernard/0000-0001-5826-5755; Gayrard, Nathalie/0000-0001-8283-8429; Raynaud, Fabrice/0000-0003-3055-0524; dupuy, anne marie/0000-0001-6538-3944; Lambert, Karen/0000-0002-6389-2451; , Jean-Paul Cristol/0000-0001-8563-7278 FU (SANIA company) FX Except YFD (who received help from University of Cocody and a modest grant from SANIA company), the authors have not received any funding or benefits from industry to conduct this study. 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J. Nutr. PD DEC PY 2019 VL 58 IS 8 BP 3091 EP 3107 DI 10.1007/s00394-018-1854-3 PG 17 WC Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Nutrition & Dietetics GA JL2XQ UT WOS:000495395500010 PM 30392135 DA 2026-02-02 ER PT J AU Gotsis, E Anagnostis, P Mariolis, A Vlachou, A Katsiki, N Karagiannis, A AF Gotsis, Efthymios Anagnostis, Panagiotis Mariolis, Anargyros Vlachou, Athanasia Katsiki, Niki Karagiannis, Asterios TI Health Benefits of the Mediterranean Diet: An Update of Research Over the Last 5 Years SO ANGIOLOGY LA English DT Review DE Mediterranean diet; inflammation; atherosclerosis; metabolic syndrome; carotid intima-media thickness; cardiovascular disease; cancer ID INTIMA-MEDIA THICKNESS; LOW-DENSITY-LIPOPROTEIN; CORONARY-HEART-DISEASE; FATTY LIVER-DISEASE; CARDIOVASCULAR RISK-FACTORS; AERODIGESTIVE TRACT CANCER; METABOLIC SYNDROME; OLIVE OIL; URIC-ACID; WEIGHT-LOSS AB The Mediterranean Diet (MedDiet) has been reported to be protective against the occurrence of several diseases. Increasing evidence suggests that the MedDiet could counter diseases associated with chronic inflammation, including metabolic syndrome, atherosclerosis, cancer, diabetes, obesity, pulmonary diseases, and cognition disorders. Adoption of a MedDiet was associated with beneficial effects on the secretion of anti-inflammatory cytokines, antioxidant cellular and circulating biomarkers as well as with regulation of gene polymorphisms involved in the atherosclerotic process. The MedDiet has been considered for the prevention of cardiovascular and other chronic degenerative diseases focusing on the impact of a holistic dietary approach rather than on single nutrients. Epidemiological dietary scores measuring adherence to a MedDiet have been developed. This narrative review considers the results of up-to-date clinical studies (with a focus on the last 5 years) that evaluated the effectiveness of the MedDiet in reducing the prevalence of chronic and degenerative diseases. C1 [Gotsis, Efthymios; Anagnostis, Panagiotis; Vlachou, Athanasia; Katsiki, Niki; Karagiannis, Asterios] Aristotle Univ Thessaloniki, Sch Med, Hippokrat Hosp, Propedeut Dept Internal Med 2, Thessaloniki 23100, Sparta, Greece. [Mariolis, Anargyros] Ctr Hlth, Areopoli, Greece. C3 Aristotle University of Thessaloniki RP Gotsis, E (通讯作者)，Aristotle Univ Thessaloniki, Sch Med, Hippokrat Hosp, Propedeut Dept Internal Med 2, 70 Leonidou Str, Thessaloniki 23100, Sparta, Greece. 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WOS:000352783800002 PM 24778424 DA 2026-02-02 ER PT J AU García-Montero, C Fraile-Martínez, O Gómez-Lahoz, AM Pekarek, L Castellanos, AJ Noguerales-Fraguas, F Coca, S Guijarro, LG García-Honduvilla, N Asúnsolo, A Sanchez-Trujillo, L Lahera, G Bujan, J Monserrat, J Alvarez-Mon, M Alvarez-Mon, MA Ortega, MA AF Garcia-Montero, Cielo Fraile-Martinez, Oscar Gomez-Lahoz, Ana M. Pekarek, Leonel Castellanos, Alejandro J. Noguerales-Fraguas, Fernando Coca, Santiago Guijarro, Luis G. Garcia-Honduvilla, Natalio Asunsolo, Angel Sanchez-Trujillo, Lara Lahera, Guillermo Bujan, Julia Monserrat, Jorge Alvarez-Mon, Melchor Alvarez-Mon, Miguel A. Ortega, Miguel A. TI Nutritional Components in Western Diet Versus Mediterranean Diet at the Gut Microbiota-Immune System Interplay. Implications for Health and Disease SO NUTRIENTS LA English DT Review DE gut microbiota; host immunometabolism; intestinal barrier; mediterranean diet; western diet; immunomodulation; food matrix; micronutrients; malnutrition ID CHAIN FATTY-ACIDS; ULTRA-PROCESSED FOODS; SEGMENTED FILAMENTOUS BACTERIA; INTESTINAL BARRIER FUNCTION; ARYL-HYDROCARBON RECEPTOR; VITAMIN-D DEFICIENCY; VIRGIN OLIVE OIL; MUCOSAL IMMUNE; LIVER-DISEASE; BILE-ACIDS AB The most prevalent diseases of our time, non-communicable diseases (NCDs) (including obesity, type 2 diabetes, cardiovascular diseases and some types of cancer) are rising worldwide. All of them share the condition of an "inflammatory disorder", with impaired immune functions frequently caused or accompanied by alterations in gut microbiota. These multifactorial maladies also have in common malnutrition related to physiopathology. In this context, diet is the greatest modulator of immune system-microbiota crosstalk, and much interest, and new challenges, are arising in the area of precision nutrition as a way towards treatment and prevention. It is a fact that the westernized diet (WD) is partly responsible for the increased prevalence of NCDs, negatively affecting both gut microbiota and the immune system. Conversely, other nutritional approaches, such as Mediterranean diet (MD), positively influence immune system and gut microbiota, and is proposed not only as a potential tool in the clinical management of different disease conditions, but also for prevention and health promotion globally. Thus, the purpose of this review is to determine the regulatory role of nutritional components of WD and MD in the gut microbiota and immune system interplay, in order to understand, and create awareness of, the influence of diet over both key components. C1 [Garcia-Montero, Cielo; Fraile-Martinez, Oscar; Gomez-Lahoz, Ana M.; Pekarek, Leonel; Castellanos, Alejandro J.; Coca, Santiago; Garcia-Honduvilla, Natalio; Sanchez-Trujillo, Lara; Lahera, Guillermo; Bujan, Julia; Monserrat, Jorge; Alvarez-Mon, Melchor; Alvarez-Mon, Miguel A.; Ortega, Miguel A.] Univ Alcala, Fac Med & Hlth Sci, Dept Med & Med Special, Alcala De Henares 28801, Spain. [Noguerales-Fraguas, Fernando; Asunsolo, Angel] Univ Alcala, Fac Med & Hlth Sci, Dept Surg Med & Social Sci, Alcala De Henares 28801, Spain. [Noguerales-Fraguas, Fernando] Principe Asturias Hosp, Dept Gen Surg, Alcala De Henares 28806, Spain. [Coca, Santiago; Guijarro, Luis G.; Garcia-Honduvilla, Natalio; Asunsolo, Angel; Sanchez-Trujillo, Lara; Lahera, Guillermo; Bujan, Julia; Monserrat, Jorge; Alvarez-Mon, Melchor; Alvarez-Mon, Miguel A.; Ortega, Miguel A.] Ramon y Cajal Inst Sanit Res IRYCIS, Madrid 28034, Spain. [Coca, Santiago; Garcia-Honduvilla, Natalio; Bujan, Julia; Monserrat, Jorge; Alvarez-Mon, Melchor; Alvarez-Mon, Miguel A.; Ortega, Miguel A.] Univ Ctr Def Madrid CUD ACD, Madrid 28047, Spain. [Guijarro, Luis G.] Univ Alcala, Dept Syst Biol, Unit Biochem & Mol Biol CIBEREHD, Alcala De Henares 28801, Spain. [Sanchez-Trujillo, Lara] Hosp Univ Principe Asturias, Serv Pediat, Madrid 28806, Spain. [Lahera, Guillermo] Univ Hosp Principe Asturias, Ctr Biomed Res Mental Hlth Network, Psychiat Serv, Alcala De Henares 28806, Spain. [Alvarez-Mon, Melchor] Univ Hosp Principe Asturias, Oncol Serv Internal Med, CIBEREHD, Immune Syst Dis Rheumatol, Alcala De Henares 28806, Spain. [Alvarez-Mon, Miguel A.] Hosp Univ Infanta Leonor, Dept Psychiat & Med Psychol, Madrid 28031, Spain. [Ortega, Miguel A.] Hosp Univ Principe Asturias, Canc Registry & Pathol Dept, Alcala De Henares 28806, Spain. C3 Universidad de Alcala; Universidad de Alcala; Prince of Asturias University Hospital; Universidad de Alcala; Prince of Asturias University Hospital; Prince of Asturias University Hospital; Prince of Asturias University Hospital; CIBER - Centro de Investigacion Biomedica en Red; CIBEREHD; Universidad de Alcala; Hospital Universitario Infanta Leonor; Prince of Asturias University Hospital RP Alvarez-Mon, MA (通讯作者)，Univ Alcala, Fac Med & Hlth Sci, Dept Med & Med Special, Alcala De Henares 28801, Spain.; Alvarez-Mon, MA (通讯作者)，Ramon y Cajal Inst Sanit Res IRYCIS, Madrid 28034, Spain.; Alvarez-Mon, MA (通讯作者)，Univ Ctr Def Madrid CUD ACD, Madrid 28047, Spain.; Alvarez-Mon, MA (通讯作者)，Hosp Univ Infanta Leonor, Dept Psychiat & Med Psychol, Madrid 28031, Spain. EM cielo.gmontero@gmail.com; oscarfra.7@hotmail.com; alahoz1199@gmail.com; leonel.pekarek@gmail.com; alejandrolivealcala@gmail.com; fernando.noguerales@uah.es; s.coca@uah.es; luis.gonzalez@uah.es; natalio.garcia@uah.es; angel.asunsolo@uah.es; larasancheztrujillo@gmail.com; guillermo.lahera@gmail.com; mjulia.bujan@uah.es; jorge.monserrat@uah.es; maalvarez.gonzalez@salud.madrid.org; mademons@gmail.com; miguel.angel.ortega92@gmail.com RI ; García Montero, Cielo/AHD-2655-2022; Fraile Martínez, Óscar/JWO-9078-2024; Asunsolo del Barco, Angel/D-8050-2018; Lahera, Guillermo/A-6593-2018; Garcia-Honduvilla, Natalio/GLQ-5957-2022 OI Ana María, Gómez Lahoz/0000-0003-3981-5138; bujan, Julia/0000-0003-2419-2476; Monserrat Sanz, Jorge/0000-0003-1775-4645; Ortega, Miguel A/0000-0003-2588-1708; García Montero, Cielo/0000-0001-6016-7855; Jiménez Castellanos, Alejano/0000-0002-4585-8911; Pekarek, Leonel/0000-0002-5966-9003; Fraile Martínez, Óscar/0000-0002-4494-6397; Sánchez-Trujillo, Lara/0000-0002-0908-7566; Alvarez-Mon Soto, Melchor/0000-0003-1309-7510; Asunsolo del Barco, Angel/0000-0001-7898-4685; Lahera, Guillermo/0000-0002-6152-3564; FU Fondo de Investigacion de la Seguridad Social, Instituto de Salud Carlos III, Spain [PI18/01726]; Programa de Actividades de I+D de la Comunidad de Madrid en Biomedicina, Madrid, Spain [B2017/BMD3804]; Instituto de Salud Carlos III CIBER Enfermedades hepaticas y Digestivas, Spain FX This work was partially supported by grants from the Fondo de Investigacion de la Seguridad Social, Instituto de Salud Carlos III (PI18/01726), Spain, Programa de Actividades de I+D de la Comunidad de Madrid en Biomedicina (B2017/BMD3804), Madrid, Spain and Instituto de Salud Carlos III CIBER Enfermedades hepaticas y Digestivas, Spain. 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Tilg, Herbert TI Western diets and chronic diseases SO NATURE MEDICINE LA English DT Review ID FATTY LIVER-DISEASE; GUIDELINE CLINICAL NUTRITION; HUMAN GUT MICROBIOME; CARDIOVASCULAR-DISEASE; INTESTINAL MICROBIOTA; MEDITERRANEAN DIET; WEIGHT-LOSS; PHYSICAL-ACTIVITY; RANDOMIZED-TRIAL; LOW-CARBOHYDRATE AB 'Westernization', which incorporates industrial, cultural and dietary trends, has paralleled the rise of noncommunicable diseases across the globe. Today, the Western-style diet emerges as a key stimulus for gut microbial vulnerability, chronic inflammation and chronic diseases, affecting mainly the cardiovascular system, systemic metabolism and the gut. Here we review the diet of modern times and evaluate the threat it poses for human health by summarizing recent epidemiological, translational and clinical studies. We discuss the links between diet and disease in the context of obesity and type 2 diabetes, cardiovascular diseases, gut and liver diseases and solid malignancies. We collectively interpret the evidence and its limitations and discuss future challenges and strategies to overcome these. We argue that healthcare professionals and societies must react today to the detrimental effects of the Western diet to bring about sustainable change and improved outcomes in the future. This Review outlines how Western-style diets contribute to the rising incidence of chronic, noncommunicable diseases by converging on key mechanisms, including gut microbial rarefaction and chronic inflammation. C1 [Adolph, Timon E.; Tilg, Herbert] Med Univ Innsbruck, Dept Internal Med Gastroenterol Hepatol Endocrinol, Innsbruck, Austria. C3 Medical University of Innsbruck RP Adolph, TE; Tilg, H (通讯作者)，Med Univ Innsbruck, Dept Internal Med Gastroenterol Hepatol Endocrinol, Innsbruck, Austria. EM timon-erik.adolph@i-med.ac.at; herbert.tilg@i-med.ac.at RI Tilg, Herbert/AEO-9569-2022 FU European Research Council [101039320]; Austrian Science Fund [P33070, FG15]; European Research Council (ERC) [101039320] Funding Source: European Research Council (ERC); Austrian Science Fund (FWF) [FG15, P33070] Funding Source: Austrian Science Fund (FWF) FX T.E.A. received funding from the European Research Council under the European Union's Horizon 2020 Research and Innovation Programme (101039320) and the Austrian Science Fund (P33070 and FG15). 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2016, CELL, V165, P111, DOI 10.1016/j.cell.2016.02.011 ,, 2017, New England Journal of Medicine, V377, P13 NR 293 TC 83 Z9 89 U1 16 U2 67 PU NATURE PORTFOLIO PI BERLIN PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY SN 1078-8956 EI 1546-170X J9 NAT MED JI Nat. Med. PD AUG PY 2024 VL 30 IS 8 BP 2133 EP 2147 DI 10.1038/s41591-024-03165-6 EA JUL 2024 PG 15 WC Biochemistry & Molecular Biology; Cell Biology; Medicine, Research & Experimental WE Science Citation Index Expanded (SCI-EXPANDED) SC Biochemistry & Molecular Biology; Cell Biology; Research & Experimental Medicine GA D5R3W UT WOS:001281347100001 PM 39085420 HC Y HP N DA 2026-02-02 ER PT J AU Li, ZY Wu, J Zhao, YP Song, JJ Wen, YD AF Li, Zhongyu Wu, Jiao Zhao, Yingpan Song, Jinjie Wen, Yandong TI Natural products and dietary interventions on liver enzymes: an umbrella review and evidence map SO FRONTIERS IN NUTRITION LA English DT Review DE natural products; dietary interventions; liver enzymes; umbrella review; evidence map ID MEDITERRANEAN DIET; VITAMIN-D; DISEASE; METAANALYSIS; SILYMARIN; FAILURE AB Background: The association between natural products and dietary interventions on liver enzymes is unclear; therefore, this study aimed to examine their effects on liver enzymes in adults. Methods: PubMed, Embase, and Cochrane Library of Systematic Reviews databases were searched from inception until March 2023. The Assessment of Multiple Systematic Reviews-2 (AMSTAR-2) and Grading of Recommendations Assessment, Development, and Evaluation (GRADE) systems were used to assess the methodological and evidence quality, and the therapeutic effects were summarized in a narrative form. Results: A total of 40 meta-analyses on natural products (n = 25), dietary supplements (n = 10), and dietary patterns (n = 5) were evaluated, and results were presented in a narrative form. The overall methodological quality of the included studies was relatively poor. The results indicated that positive effects were observed for nigella sativa, garlic, artichoke, curcumin, silymarin, vitamin E, vitamin D, L-carnitine, propolis, and polyunsaturated fatty acids on certain liver enzymes. The dietary patterns, including high-protein, Mediterranean, and calorie-restriction diets and evening snacks, may reduce liver enzymes; however, other supplements and herbs did not reduce liver enzyme levels or have minimal effects. The evidence quality was generally weak given the risk of bias, heterogeneity, and imprecision. Conclusion: This umbrella review suggests that natural products and dietary interventions have beneficial therapeutic effects on liver enzymes levels. Further clinical trials are necessary to establish the effectiveness of supplements that reduce liver enzymes. C1 [Li, Zhongyu; Wen, Yandong] China Acad Chinese Med Sci, Eye Hosp, Dept Chinese Med, Beijing, Peoples R China. [Wu, Jiao; Song, Jinjie] China Acad Chinese Med Sci, Xiyuan Hosp, Dept Oncol, Beijing, Peoples R China. [Zhao, Yingpan] China Acad Chinese Med Sci, Xiyuan Hosp, Inst Digest Dis, Beijing, Peoples R China. C3 China Academy of Chinese Medical Sciences; Eye Hospital, CACMS; China Academy of Chinese Medical Sciences; Xiyuan Hospital, CACMS; China Academy of Chinese Medical Sciences; Xiyuan Hospital, CACMS RP Wen, YD (通讯作者)，China Acad Chinese Med Sci, Eye Hosp, Dept Chinese Med, Beijing, Peoples R China. EM 3180200182@caa.edu.cn FU Central High-Level Traditional Chinese Medicine Hospital Project of Eye Hospital, China Academy of Chinese Medical Science [GSP5-17] FX The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This manuscript was supported by the Central High-Level Traditional Chinese Medicine Hospital Project of Eye Hospital, China Academy of Chinese Medical Science (GSP5-17). 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Nutr. PD FEB 2 PY 2024 VL 11 AR 1300860 DI 10.3389/fnut.2024.1300860 PG 16 WC Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Nutrition & Dietetics GA HW4X6 UT WOS:001162543400001 PM 38371505 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Zhou, YF Zhang, LY Guo, FR Liu, XY Li, X Han, ZD Li, XW Shi, XY Wen, LX Wang, J AF Zhou, Yingfang Zhang, Linyu Guo, Fangrui Liu, Xiangyan Li, Xin Han, Zongding Li, Xiaowen Shi, Xingyong Wen, Lixin Wang, Ji TI Metabolomic and Transcriptomic Analysis of Effects of Three MUFA-Rich Oils on Hepatic Glucose and Lipid Metabolism in Mice SO MOLECULAR NUTRITION & FOOD RESEARCH LA English DT Article DE Lard; Lipid metabolism; Monounsaturated fatty acids; Olive oil; Omic analysis; Rapeseed oil ID NONALCOHOLIC FATTY LIVER; ACTIVATED RECEPTOR-GAMMA; INSULIN SENSITIVITY; MEDITERRANEAN DIET; FRUCTOSE; TRIGLYCERIDES; MICROBIOTA; ADHERENCE; TISSUE AB ScopeOlive oil, rapeseed oil, and lard are dietary fats rich in monounsaturated fatty acids, but the effects of dietary oils enriched in monounsaturated fatty acids on hepatic lipid deposition have seldom been compared.Methods and resultsNinety 8-week-old C57BL/6J male mice are randomly divided into six groups and fed diets containing lard, rapeseed oil, or olive oil with a 10% or 45% fat energy supply for 16 weeks. Under high-fat conditions, serum total cholesterol levels in the lard and olive oil groups are significantly higher than those in the rapeseed oil group. Hepatic lipid content in the olive oil group is higher than that in the other two groups. Compared with rapeseed oil, lard increases the liver levels of arachidonic, palmitic, and myristic acids and decreases the levels of eicosapentaenoic linolenic acid and linoleic acid. Olive oil increases the liver levels of docosatrienoic, arachidonic, oleic, and myristic acids; maltose; and fructose and decreases the levels of eicosapentaenoic, linolenic, and linoleic acids.ConclusionOlive oil probably causes hepatic lipid deposition in mice, which may enhance hepatic lipid synthesis by activating the starch and sucrose metabolic pathways. By contrast, rapeseed oil shows a significant anti-lipid deposition effect on the liver. Olive oil, rapeseed oil, and lard are dietary fats that are rich in monounsaturated fatty acids. This study investigates the effects of three dietary oils on hepatic glucose and lipid metabolism in mice. Compared to rapeseed oil and lard, olive oil is most likely to cause hepatic lipid deposition by activating the metabolic pathways of starch and sucrose. image C1 [Zhou, Yingfang; Zhang, Linyu; Guo, Fangrui; Liu, Xiangyan; Li, Xin; Shi, Xingyong; Wen, Lixin; Wang, Ji] Hunan Agr Univ, Coll Vet Med, Hunan Engn Res Ctr Livestock & Poultry Hlth Care, Changsha 410128, Peoples R China. [Li, Xin] Changsha Lvye Biotechnol Co Ltd, Changsha 410100, Peoples R China. [Han, Zongding] Hunan Agr Univ, Orient Sci & Technol Coll, Changsha 410128, Peoples R China. [Wang, Ji] Hunan Agr Univ, Coll Anim Sci & Technol, Anim Nutr Genome & Germplasm Innovat Res Ctr, Changsha 410128, Peoples R China. C3 Hunan Agricultural University; Hunan Agricultural University; Hunan Agricultural University RP Wen, LX; Wang, J (通讯作者)，Hunan Agr Univ, Coll Vet Med, Hunan Engn Res Ctr Livestock & Poultry Hlth Care, Changsha 410128, Peoples R China. EM wenlixin@hunau.edu.cn; wangjics@hunau.edu.cn FU The authors would like to thank the Special Funds for the Construction of Innovative Provinces in Hunan Province (Grant No. 2020NK2032). They would also like to thank Editage () for the English language editing. [2020NK2032]; Special Funds for the Construction of Innovative Provinces in Hunan Province FX The authors would like to thank the Special Funds for the Construction of Innovative Provinces in Hunan Province (Grant No. 2020NK2032). They would also like to thank Editage () for the English language editing. 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Nutr. Food Res. PD DEC PY 2023 VL 67 IS 23 DI 10.1002/mnfr.202300398 EA OCT 2023 PG 11 WC Food Science & Technology WE Science Citation Index Expanded (SCI-EXPANDED) SC Food Science & Technology GA LV3D4 UT WOS:001087470600001 PM 37867207 OA Bronze DA 2026-02-02 ER PT J AU Trovato, FM Castrogiovanni, P Szychlinska, MA Purrello, F Musumeci, G AF Trovato, Francesca Maria Castrogiovanni, Paola Szychlinska, Marta Anna Purrello, Francesco Musumeci, Giuseppe TI Impact of Western and Mediterranean Diets and Vitamin D on Muscle Fibers of Sedentary Rats SO NUTRIENTS LA English DT Article DE Mediterranean diet; high-fat diet; skeletal muscle; vitamin D; extra-virgin olive oil ID FATTY LIVER-DISEASE; SKELETAL-MUSCLE; CARTILAGE DEGENERATION; INSULIN-RESISTANCE; IMMUNE-SYSTEM; OLIVE OIL; IN-VIVO; SARCOPENIA; LUBRICIN; SUPPLEMENTATION AB Background: The metabolic syndrome is associated with sarcopenia. Decreased serum levels of Vitamin D (VitD) and insulin-like growth factor (IGF)-1 and their mutual relationship were also reported. We aimed to evaluate whether different dietary profiles, containing or not VitD, may exert different effects on muscle molecular morphology. Methods: Twenty-eight male rats were fed for 10 weeks in order to detect early defects induced by different dietary regimens: regular diet (R); regular diet with vitamin D supplementation (R-DS) and regular diet with vitamin D restriction (R-DR); high-fat butter-based diets (HFB-DS and HFB-DR) with 41% energy from fat; high-fat extra-virgin olive oil-based diets (HFEVO-DS and HFEVO-DR) with 41% energy from fat. IL-1 beta, insulin-like growth factor (IGF)1, Dickkopf-1 (DKK-1), and VitD-receptor (VDR) expressions were evaluated by immunohistochemistry. Muscle fiber perimeter was measured by histology and morphometric analysis. Results: The muscle fibers of the HEVO-DS rats were hypertrophic, comparable to those of the R-DS rats. An inverse correlation existed between the dietary fat content and the perimeter of the muscle fibers (p < 0.01). In the HFB-DR rats, the muscle fibers appeared hypotrophic with an increase of IL-1 beta and a dramatic decrease of IGF-1 expression. Conclusions: High-fat western diet could impair muscle metabolism and lay the ground for subsequent muscle damage. VitD associated with a Mediterranean diet showed trophic action on the muscle fibers. C1 [Trovato, Francesca Maria; Purrello, Francesco] Univ Catania, Dept Clin & Expt Med, Via S Sofia 78, I-95123 Catania, Italy. [Castrogiovanni, Paola; Szychlinska, Marta Anna; Musumeci, Giuseppe] Univ Catania, Sch Med, Human Anat & Histol Sect, Dept Biomed & Biotechnol Sci, Via S Sofia 87, I-95123 Catania, Italy. C3 University of Catania; University of Catania RP Musumeci, G (通讯作者)，Univ Catania, Sch Med, Human Anat & Histol Sect, Dept Biomed & Biotechnol Sci, Via S Sofia 87, I-95123 Catania, Italy. EM trovatofrancesca@gmail.com; pacastro@unict.it; marta.sz@hotmail.it; fpurrell@unict.it; g.musumeci@unict.it RI SZYCHLINSKA, Marta Anna/AAA-5720-2021; Castrogiovanni, Paola/E-3152-2013; Musumeci, Giuseppe/K-9955-2016; PURRELLO, Francesco Salvatore/K-9721-2016 OI SZYCHLINSKA, Marta Anna/0000-0001-5281-1516; Trovato, Francesca Maria/0000-0002-8048-1646; Musumeci, Giuseppe/0000-0002-8260-8890; PURRELLO, Francesco Salvatore/0000-0003-3313-8543 FU Department of Biomedical and Biotechnological Sciences (BIOMETEC), University of Catania, Italy FX This study was supported by the University Research Project Grant (Triennial Research Plan 2016-2018), Department of Biomedical and Biotechnological Sciences (BIOMETEC), University of Catania, Italy. The authors would like to thank "Oleificio Guccione di Divita Vito e G. SAS" for providing them with the extra-virgin Sicilian olive oil and Iain Halliday for commenting and making corrections to the paper. 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Baylin, Ana Bellatorre, Anna Scherzinger, Ann Goran, Michael I. Dabelea, Dana TI A Prudent dietary pattern is inversely associated with liver fat content among multi-ethnic youth SO PEDIATRIC OBESITY LA English DT Article DE adolescents; diet; epidemiology; hepatic fat fraction; non‐ alcoholic fatty liver disease ID EXPLORING PERINATAL OUTCOMES; MEDITERRANEAN DIET; PHYSICAL-ACTIVITY; UNITED-STATES; HEPATIC FAT; DISEASE; CHILDREN; RISK; FOOD; ADOLESCENTS AB Objectives To identify dietary patterns associated with hepatic fat fraction (HFF), a measure of liver fat content and risk factor for non-alcoholic fatty liver disease, in a prospective study of 397 multi-ethnic youth. Methods We obtained information on habitual dietary intake via the Block Kids Food Frequency Questionnaire at age 6 to 15 years ('T1') and 12 to 19 years ('T2'), and measured HFF using magnetic resonance imaging at T2. We derived dietary patterns via principal components analysis and examined associations with ln-transformed HFF using linear regression models that accounted for maternal education, gestational diabetes exposure and smoking habits; and child pubertal status, BMI and physical activity. Results At T1, none of the dietary patterns identified were associated with HFF measured at T2. At T2, a Prudent dietary pattern characterized by high fruit and vegetable intake was inversely associated with HFF (-0.08 [95% CI: -0.16, -0.00]). Similarly, increased adherence to the Prudent pattern across T1 and T2 corresponded with lower ln-HFF (-0.11 [-0.18, -0.04] units). On the other hand, adherence to a Western pattern comprising fried foods and refined carbohydrates at T2 correlated with higher HFF among non-Hispanic White participants (0.16 [0.06, 0.26]). These findings persisted after accounting for child BMI. Conclusions Even in healthy youth, a diet high in fruits and vegetables is associated with lower HFF, whereas a diet high in fried foods and refined carbohydrates is related to higher HFF. Dietary changes may serve as an early preventive measure to mitigate liver fat accrual. C1 [Perng, Wei; Harte, Robyn; Ringham, Brandy M.; Bellatorre, Anna; Dabelea, Dana] Univ Colorado Anschutz Med Campus, Lifecourse Epidemiol Adipos & Diabet LEAD Ctr, Aurora, CO USA. [Perng, Wei; Dabelea, Dana] Colorado Sch Publ Hlth, Dept Epidemiol, 12474 East 19th Ave,Room 208, Aurora, CO 80045 USA. [Perng, Wei; Baylin, Ana] Univ Michigan, Sch Publ Hlth, Dept Nutr Sci, Ann Arbor, MI 48109 USA. [Scherzinger, Ann] Univ Colorado, Dept Radiol, Sch Med, Aurora, CO USA. [Goran, Michael I.] Childrens Hosp Los Angeles, Saban Res Inst, Program Diabet & Obes, Los Angeles, CA 90027 USA. [Dabelea, Dana] Univ Colorado, Dept Pediat, Sch Med, Aurora, CO USA. C3 University of Colorado System; University of Colorado Anschutz Medical Campus; Colorado School of Public Health; University of Michigan System; University of Michigan; University of Colorado System; University of Colorado Anschutz Medical Campus; Children's Hospital Los Angeles; University of Colorado System; University of Colorado Anschutz Medical Campus RP Perng, W (通讯作者)，Colorado Sch Publ Hlth, Dept Epidemiol, 12474 East 19th Ave,Room 208, Aurora, CO 80045 USA. EM wei.perng@cuanschutz.edu FU NIH, National Institute of Diabetes, Digestive, and Kidney Diseases [R01 DK068001]; [KL2-TR002534]; NIH Office of the Director; National Center for Advancing Translational Sciences [KL2TR002534] Funding Source: NIH RePORTER FX This work was supported by the NIH, National Institute of Diabetes, Digestive, and Kidney Diseases (R01 DK068001). Wei Perng is supported by KL2-TR002534. The funders had no role in the conceptualization, implementation or interpretation of this work. 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Obes. PD JUN PY 2021 VL 16 IS 6 AR e12758 DI 10.1111/ijpo.12758 EA DEC 2020 PG 9 WC Pediatrics WE Science Citation Index Expanded (SCI-EXPANDED) SC Pediatrics GA RY0PA UT WOS:000596713300001 PM 33296951 OA Green Submitted DA 2026-02-02 ER PT J AU MCCLELLAND, G ZWINGELSTEIN, G WEBER, JM BRICHON, G AF MCCLELLAND, G ZWINGELSTEIN, G WEBER, JM BRICHON, G TI LIPID-COMPOSITION OF TISSUE AND PLASMA IN 2 MEDITERRANEAN FISHES, THE GILT HEAD SEA BREAM (CHRYSOPHYRYS-AURATUS) AND THE EUROPEAN SEA-BASS (DICENTRARCHUS-LABRAX) SO CANADIAN JOURNAL OF FISHERIES AND AQUATIC SCIENCES LA English DT Article ID TROUT ONCORHYNCHUS-MYKISS; KETONE-BODY METABOLISM; FATTY-ACID COMPOSITION; SALMO-GAIRDNERI; RED MUSCLE; BLOOD; GLUCOSE; ORGANIZATION; EXERCISE; TURNOVER AB The fatty acid (FA) composition of phospholipid (PL), triacylglycerol (TAG), and total lipid (TL) fractions was determined for liver, adipose tissue, white muscle, and plasma of European seabass (Dicentrarchus labrax) and gilt-head sea bream (Chrysophyrys auratus) fed on the same diet. FA composition of plasma nonesterified fatty acids (NEFA) and TAG as well as tissue TAG and TL correlates with that of the diet. FA composition of PL in tissues and plasma was different from that of the diet and different in the two species. Contribution to tissue wet weight of the different lipid fractions showed that both species store lipid primarily outside of muscle (only 3% in both species) as TAG in adipose tissue (about 80% lipid . wet weight(-1)). Seabass store 33% wet weight of lipid in liver, while sea bream store only 5% wet weight. The plasma concentration of NEFA and TAG is 2223 and 12 260 nmol . ml(-1) for seabass and 2790 and 9670 nmol . ml(-1) for sea bream. The data show that these two fishes with similar lifestyle store lipid in the same fashion and that dietary FA composition affects the FA composition of TL and TAG fractions but not PL in tissue and plasma. C1 UNIV OTTAWA, OTTAWA, ON K1N 6N5, CANADA. 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PD JAN PY 1995 VL 52 IS 1 BP 161 EP 170 DI 10.1139/f95-016 PG 10 WC Fisheries; Marine & Freshwater Biology WE Science Citation Index Expanded (SCI-EXPANDED) SC Fisheries; Marine & Freshwater Biology GA RG860 UT WOS:A1995RG86000016 DA 2026-02-02 ER PT J AU Mercurio, G Giacco, A Troise, AD Ledbetter, M De Pascale, S Scopigno, N Vigliotti, M Mazzola, M Riccio, G Scaloni, A Moreno, M Fiore, A Cioffi, F Silvestri, E AF Mercurio, Giovanna Giacco, Antonia Troise, Antonio Dario Ledbetter, Moira De Pascale, Sabrina Scopigno, Nicla Vigliotti, Michela Mazzola, Matteo Riccio, Giuseppe Scaloni, Andrea Moreno, Maria Fiore, Alberto Cioffi, Federica Silvestri, Elena TI A Mediterranean Diet-Based Food Mix Ameliorates Diabetes- and Obesity-Associated Liver Alterations Through Mitochondrial and Metabolic Reprogramming SO MOLECULAR NUTRITION & FOOD RESEARCH LA English DT Article DE autophagy; mitochondrial biogenesis; mitochondrial dynamics; mitophagy; OXPHOS ID INSULIN-RESISTANCE; HEPATIC STEATOSIS; DISEASE; MICE; BIOMARKERS; MANAGEMENT; STRESS; HEALTH; ESTER AB Metabolic syndrome (MetS)-related diseases, such as type 2 diabetes (T2D) and obesity, are among the leading causes of liver damage, and their prevalence poses an increasing clinical challenge. The Mediterranean diet (MD) has shown promising effects in managing MetS, reducing mortality and morbidity. However, the precise biochemical and molecular mechanisms underlying the MD efficacy remain unclear. This study evaluated the effects of a lab-designed balanced food mix, simulating the 1960s MD, on hepatic metabolic dysfunction in obese and diabetic db/db mice.The MD cocktail, naturally rich in polyphenols, fructose, and monounsaturated fatty acids, prevented hyperlipidemia while not reversing diabetes and obesity. Gene expression, protein representation, and metabolomic analyses of liver tissues from MD-fed db/db mice revealed reduced oxidative damage, preserved mitochondrial quality control, enhanced autophagy markers, and reduced fibrosis markers. The MD cocktail also enhanced liver mitochondrial mass and stimulated the OXPHOS system. It also preserved the hepatic pool of acylated carnitine derivatives and chenodeoxycholic acid, suggesting protective effects on mitochondrial beta-oxidation and bile acid biosynthesis, with an overall improvement of metabolite profiles.The experimental MD cocktail exerted significant hepatoprotective effects, mitigating several diabetes- and obesity-induced hepatic disturbances and beneficially affecting metabolic fluxes and tissue texture. C1 [Mercurio, Giovanna; Giacco, Antonia; Scopigno, Nicla; Vigliotti, Michela; Moreno, Maria; Cioffi, Federica; Silvestri, Elena] Univ Sannio, Dept Sci & Technol, Benevento, Italy. [Troise, Antonio Dario; De Pascale, Sabrina; Scaloni, Andrea] CNR, Inst Anim Prod Syst Mediterranean Environm, Prote Metabol & Mass Spectrometry Lab, Portici, Italy. [Ledbetter, Moira; Fiore, Alberto] Univ Abertay, Sch Appl Sci, Div Engn & Food Sci, Dundee, Scotland. [Mazzola, Matteo] Azienda Osped Univ Pisana, Cardiothorac & Vasc Dept, Pisa, Italy. [Riccio, Giuseppe] ISAMA Srl, Salerno, SA, Italy. C3 University of Sannio; Consiglio Nazionale delle Ricerche (CNR); Istituto Per Il Sistema Produzione Animale In Ambiente Mediterraneo (ISPAAM-CNR); University of Abertay Dundee; University of Pisa; Azienda Ospedaliero Universitaria Pisana RP Silvestri, E (通讯作者)，Univ Sannio, Dept Sci & Technol, Benevento, Italy. EM silvestri@unisannio.it RI Troise, Antonio/O-6113-2017; cioffi, federica/AAB-8161-2019; Mazzola, Matteo/HPC-2331-2023; Fiore, Alberto/D-1171-2019; De Pascale, Sabrina/HKE-2021-2023 OI Ledbetter, Moira/0000-0002-8009-6529; Fiore, Alberto/0000-0001-9490-0090; De Pascale, Sabrina/0000-0001-9249-7058 FU Safety and Security-Working ON Foods FX This study was partially funded by "Nutraceutica, nutrigenomica e alimenti funzionali", ISTITUTO NEUROLOGICO MEDITERRANEO "NEUROMED S.p.A", Traiettoria 5, Azione 5.1, << Creazione di un programma di azione per la lotta alla malnutrizione in tutte le sue forme e per la diffusione dei principi della dieta mediterranea >> -UOR UNISANNIO (CUP: F83C22002080008) and the National Recovery and Resilience Plan, mission 4, component 2, investment 1.3, call n. 341/2022 of Italian Ministry of University and Research funded by the European Union-NextGenerationEU for the project "ON Foods-Research and innovation network on food and nutrition Sustainability, Safety and Security-Working ON Foods", project PE00000003, concession decree n. 1550/2022, CUP B83C22004790001. 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PD NOV PY 2025 VL 69 IS 21 AR e70210 DI 10.1002/mnfr.70210 EA SEP 2025 PG 20 WC Food Science & Technology WE Science Citation Index Expanded (SCI-EXPANDED) SC Food Science & Technology GA 9LJ3T UT WOS:001561385200001 PM 40891122 OA Green Accepted, Green Submitted, hybrid DA 2026-02-02 ER PT J AU Vereczkei, Z Szakács, Z Peresztegi, MZ Lemes, K Hagymási, K Dakó, S Dakó, E Lada, S Faluhelyi, N Szekeres, G Pásztor, G Farkas, N Pár, G Mezosi, E Bajor, J AF Vereczkei, Zsofia Szakacs, Zsolt Peresztegi, Mira Zsofia Lemes, Klara Hagymasi, Krisztina Dako, Sarolta Dako, Eszter Lada, Szilvia Faluhelyi, Nandor Szekeres, Gabor Pasztor, Gyula Farkas, Nelli Par, Gabriella Mezosi, Emese Bajor, Judit TI Influence of a structured, 1-year-long dietary intervention regarding body composition and cardiovascular risk (ARCTIC) in coeliac disease: a protocol of a multicentre randomised controlled trial SO BMJ OPEN LA English DT Article DE Coeliac disease; NUTRITION & DIETETICS; Clinical Trial; Randomized Controlled Trial; Health Education; Risk management ID GLUTEN-FREE DIET; MEDITERRANEAN DIET; ADHERENCE AB Introduction Coeliac disease (CD) affects 1% of the population worldwide. The only available evidence-based treatment is a strict gluten-free diet (GFD), which can readily lead to weight gain and unfavourable metabolic changes (eg, dyslipidaemia, fatty liver disease and insulin resistance) if followed without adequate dietary control. That can lead to increased cardiovascular risk (CV). We planned a randomised controlled trial to test the effect of a group-based, structured, 1-year, advanced dietary education, per the proposal of a Mediterranean diet vs standard of care, regarding the most relevant CV risk factors (eg, metabolic parameters and body composition) in CD patients. Methods and analysis Randomisation will occur after the baseline dietary education and interview in a 1:1 allocation ratio. Outcomes include anthropometric parameters (body composition analysis including weight, Body Mass Index, fat mass, per cent body fat, skeletal muscle mass, visceral fat area and total body water) and CV risk-related metabolic parameters (eg, lipid profile, homocysteine, fasting glucose, haemoglobin A1c, Homeostatic Model Assessment Index, metabolic hormones, waist circumference, blood pressure, liver function tests, liver steatosis rate and diet composition). In this study, we aim to draw attention to a new aspect regarding managing CD: dietary education can lead to a better quality of the GFD, thereby reducing the risk of potential metabolic and CV complications. Ethics and dissemination The study was approved by the Scientific and Research Ethics Committee of the Hungarian Medical Research Council (27521-5/2022/E & Uuml;IG). Findings will be disseminated at research conferences and in peer-reviewed journals. C1 [Vereczkei, Zsofia; Farkas, Nelli] Univ Pecs, Inst Translat Med, Med Sch, Pecs, Hungary. [Szakacs, Zsolt; Par, Gabriella; Mezosi, Emese; Bajor, Judit] Univ Pecs, Dept Med 1, Med Shcool, Pecs, Hungary. [Peresztegi, Mira Zsofia] Univ Pecs, Med Shcool, Pecs, Hungary. [Lemes, Klara; Lada, Szilvia] Univ Szeged, Albert Szent Gyorgy Med Sch, Dept Med, Szeged, Hungary. [Hagymasi, Krisztina; Dako, Sarolta; Dako, Eszter] Semmelweis Univ, Fac Med, Dept Surg Transplantat & Gastroenterol, Budapest, Hungary. [Faluhelyi, Nandor; Szekeres, Gabor] Univ Pecs, Med Sch, Dept Radiol, Pecs, Hungary. [Pasztor, Gyula] Univ Szeged, Albert Szent Gyorgy Med Sch, Dept Radiol, Szeged, Hungary. [Farkas, Nelli] Univ Pecs, Inst Bioanal, Med Sch, Pecs, Hungary. C3 University of Pecs; University of Pecs; University of Pecs; Szeged University; Semmelweis University; University of Pecs; Szeged University; University of Pecs RP Bajor, J (通讯作者)，Univ Pecs, Dept Med 1, Med Shcool, Pecs, Hungary. EM vereczkei47@gmail.com; szaki92@gmail.com; peresztegizs@gmail.com; drlemesklara@gmail.com; hagymasikriszti@gmail.com; dako.sarolta@gmail.com; dakoeszter7@gmail.com; lada.szilvia@med.u-szeged.hu; nandor.faluhelyi@gmail.com; szekeres.gabor@pte.hu; gyuszkapasztor@gmail.com; nelli.farkas@aok.pte.hu; pargabriella@gmail.com; mezosi.emese@pte.hu; bajor.judit@pte.hu RI Hagymasi, Krisztina/LXV-2239-2024 OI Vereczkei, Zsófia/0000-0002-8144-4628 FU University of Pecs Medical School; National Research, Development, and Innovation Office [FK142942]; New National Excellence Program of the Ministry for Culture and Innovation from the source of the National Research, Development and Innovation Fund [UNKP-23-3-II-PTE-1855] FX The project is non-industry funded. Study and center costs are covered by the University of Pecs Medical School and the National Research, Development, and Innovation Office (grant FK142942 to JB). This study is also supported by the UNKP-23-3 New National Excellence Program of the Ministry for Culture and Innovation from the source of the National Research, Development and Innovation Fund (grant UNKP-23-3-II-PTE-1855 to ZV). 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Polar lipids represented 82-90% of the total lipid in adult female livers, gonads and in eggs. Cholesterol in gonads and eggs and triacylglycerols in livers were the dominant neutral lipids. Differences in lipid classes were found in livers between the two populations, but not in their gonads and eggs. Moreover, a quantitative difference in total lipid content was evident. Young fish living on the C. taxifolia meadow in winter had 21% less lipid than those living on the P. oceanica bed. The populations of S. ocellatus showed differences between triacylglycerol versus phospholipid fatty acid compositions and between gonad versus liver fatty acid compositions. Moreover, a significant difference was found between both populations in their liver triacylglycerol fatty acid compositions, suggesting a difference in diet. 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Biol. PD MAR PY 2005 VL 146 IS 4 BP 805 EP 814 DI 10.1007/s00227-004-1465-9 PG 10 WC Marine & Freshwater Biology WE Science Citation Index Expanded (SCI-EXPANDED) SC Marine & Freshwater Biology GA 903RC UT WOS:000227442300018 DA 2026-02-02 ER PT J AU Belopolsky, Y Khan, MQ Sonnenberg, A Davidson, DJ Fimmel, CJ AF Belopolsky, Yuliya Khan, Mohammad Q. Sonnenberg, Amnon Davidson, David J. Fimmel, Claus J. TI Ketogenic, hypocaloric diet improves nonalcoholic steatohepatitis SO JOURNAL OF TRANSLATIONAL INTERNAL MEDICINE LA English DT Article DE nonalcoholic fatty liver disease; high-protein diet; metabolic syndrome; Ideal Protein diet; caloric restriction; weight management; lifestyle intervention ID FATTY LIVER-DISEASE; RANDOMIZED CONTROLLED-TRIAL; MEDITERRANEAN DIET; WEIGHT-LOSS; PHYSICAL-ACTIVITY; LOW-CARBOHYDRATE; LIFE-STYLE; INTERVENTION; SEVERITY; HEALTH AB Background and objectives: Nonalcoholic steatohepatitis (NASH) is strongly associated with obesity. A weight loss of >= 10% is necessary to improve NASH severity, but this goal has rarely been achieved in published studies using different diet protocols. The effect of a ketogenic, hypocaloric, commercial diet ("Ideal Protein," IP) on body weight, metabolic markers, and liver tests in a group of NASH patients is evaluated in this study. Daily calorie intake was tailored to achieve a weight loss of >= 10%. Methods: We analyzed 38 patients with NASH who were placed on the IP diet between 2014 and 2018 and compared their outcomes with 6 control patients who declined the diet. All patients were evaluated by a trained health coach in weekly intervals throughout the study period. Clinical and laboratory data obtained before and at 6.5 months after intervention were compared using paired t-testing. Results: The patients on the IP diet experienced a significant weight reduction (217 +/- 8 lb vs. 194 +/- 7 lb; mean +/- S.E.M.), corresponding to an average weight loss of 9.7% +/- 1.6%. Significant changes in systolic blood pressure (133 +/- 3 mmHg vs. 123 +/- 3 mmHg), triglycerides (200 +/- 21 mmol/L vs. 132 +/- 11 mmol/L), hemoglobin A1c (6.71% +/- 0.29% vs. 5.74% +/- 0.19%), SGPT (97.3 +/- 11.1 IU/L vs. 44.2 +/- 5.9 IU/L), SGOT (82.4 +/- 10.5 IU/L vs. 32.8 +/- 5.2 IU/L), and Fib-4 scores (2.25 +/- 0.23 vs. 1.40 +/- 0.13) were also observed (P<0.05 in all cases). In the IP group, 50.5% of patients lost >= 10% body weight. In contrast, no significant changes were observed in the control group. The IP diet was well tolerated, and no safety signals were noticed. Conclusions: A ketogenic, hypocaloric resulted in striking weight loss and significant improvements in metabolic parameters and liver tests, suggesting that this approach carries promise for the dietary management of patients with NASH. C1 [Belopolsky, Yuliya] NorthShore Univ Hlth Syst, Div Internal Med, Evanston, IL USA. [Khan, Mohammad Q.; Fimmel, Claus J.] NorthShore Univ Hlth Syst, Div Gastroenterol, Evanston, IL USA. [Sonnenberg, Amnon] Portland VA Med Ctr, Portland, OR USA. [Sonnenberg, Amnon] Oregon Hlth & Sci Univ, Portland, OR 97201 USA. [Davidson, David J.] NorthShore Univ Hlth Syst, Div Cardiol, Evanston, IL USA. C3 NorthShore University Health System; NorthShore University Health System; US Department of Veterans Affairs; Veterans Health Administration (VHA); Portland VA Medical Center; Oregon Health & Science University; NorthShore University Health System RP Belopolsky, Y (通讯作者)，NorthShore Univ Hlth Syst, Evanston Hosp, 2650 Ridge Ave, Evanston, IL 60201 USA. 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PY 2020 VL 8 IS 1 BP 26 EP 31 DI 10.2478/jtim-2020-0005 PG 6 WC Medicine, General & Internal WE Science Citation Index Expanded (SCI-EXPANDED) SC General & Internal Medicine GA LS9FW UT WOS:000536685400005 PM 32435609 OA Green Submitted, hybrid DA 2026-02-02 ER PT B AU Clarke, SD Gasperikova, D Nelson, C Lapillonne, A Heird, WC AF Clarke, SD Gasperikova, D Nelson, C Lapillonne, A Heird, WC BE Klimes, I Sebokova, E Howard, BV Ravussin, E TI Fatty acid regulation of gene expression - A genomic explanation for the benefits of the Mediterranean diet SO LIPIDS AND INSULIN RESISTANCE: THE ROLE OF FATTY ACID METABOLISM AND FUEL PARTITIONING SE Annals of the New York Academy of Sciences-Series LA English DT Article; Proceedings Paper CT 4th International Meeting on Lipids and Insulin Resistance CY AUG 29-SEP 02, 2001 CL SMOLENICE CASTLE, SLOVAKIA SP Astra Zeneca, European Commiss, Berlin Chemie, Coca Cola Beverages, Eli Lilly, Fournier Labs, GlaxoSmithKline, Lipha Merck, NY Acad Sci, Novo Nordisk, Pfizer, Roche Diagnost Syst, Servier, Slovak Diabetes Soc DE Mediterranean diet; obesity; insulin resistance; repartitioning agents; omega-3 fatty acids; HUFA ID ELEMENT-BINDING PROTEIN-1; CARNITINE PALMITOYLTRANSFERASE I; PROLIFERATOR-ACTIVATED RECEPTORS; RAT-LIVER; INSULIN-RESISTANCE; ADIPOSE-TISSUE; SYNTHASE GENE; MESSENGER-RNA; FISH-OIL; COORDINATE SUPPRESSION AB The development of obesity and associated insulin resistance involves a multitude of gene products, including proteins involved in lipid synthesis and oxidation, thermogenesis, and cell differentiation. The genes encoding these proteins are in essence the blueprints that we have inherited from our parents. However, what determines the way in which blueprints are interpreted is largely dictated by a collection of environmental factors. The nutrients we consume are among the most influential of these environmental factors. During the early stages of evolutionary development, nutrients functioned as primitive hormonal signals that allowed the early organisms to turn on pathways of synthesis or storage during periods of nutrient deprivation or excess. As single-cell organisms evolved into complex life forms, nutrients continued to be environmental factors that interacted with hormonal signals to govern the expression of genes encoding proteins involved in energy metabolism, cell differentiation, and cell growth. Nutrients govern the tissue content and activity of different proteins by functioning as regulators of gene transcription, nuclear RNA processing, mRNA degradation, and mRNA translation, as well as functioning as posttranslational modifiers of proteins. One dietary constituent that has a strong influence on cell differentiation, growth, and metabolism is fat. The fatty acid component of dietary lipid not only influences hormonal signaling events by modifying membrane lipid composition, but fatty acids have a very strong direct influence on the molecular events that govern gene expression. In this review, we discuss the influence that (n-9), (n-6), and (n-3) fatty acids exert on gene expression in the liver and skeletal muscle and the impact this has on intra- and interorgan partitioning of metabolic fuels. C1 Univ Texas, Inst Cellular & Mol Biol, Austin, TX 78712 USA. Univ Texas, Div Nutr Sci, Austin, TX 78712 USA. 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BN 1-57331-368-8 J9 ANN NY ACAD SCI JI Ann.NY Acad.Sci. PY 2002 VL 967 BP 283 EP 298 DI 10.1111/j.1749-6632.2002.tb04284.x PG 16 WC Endocrinology & Metabolism; Multidisciplinary Sciences WE Conference Proceedings Citation Index - Science (CPCI-S); Science Citation Index Expanded (SCI-EXPANDED) SC Endocrinology & Metabolism; Science & Technology - Other Topics GA BU83P UT WOS:000177158000028 PM 12079856 DA 2026-02-02 ER PT J AU Heden, TD Chen, C Leland, G Mashek, MM Najt, CP Shang, LS Chow, LS Mashek, DG AF Heden, Timothy D. Chen, Chen Leland, Grace Mashek, Mara M. Najt, Charles P. Shang, Linshan Chow, Lisa S. Mashek, Douglas G. TI Isolated and combined impact of dietary olive oil and exercise on markers of health and energy metabolism in female mice SO JOURNAL OF NUTRITIONAL BIOCHEMISTRY LA English DT Article DE Mediterranean diet; oleate; high-intensity interval exercise; mitochondria ID HIGH-INTENSITY INTERVAL; INSULIN-RESISTANCE; MUSCLE REGENERATION; MEDITERRANEAN DIET; FAT OXIDATION; PALMITATE; OLEATE; LIVER; INFLAMMATION; RESPONSES AB An olive oil (OO) rich diet or high-intensity interval training (HIIT) independently improve markers of health and energy metabolism, but it is unknown if combining OO and HIIT synergize to improve these markers. This study characterized the isolated and combined impact of OO and HIIT on markers of health and energy metabolism in various tissues in C57BL/6J female mice. Nine-week-old mice were divided into four groups for a 12-week diet and/or exercise intervention including: (1) Control Diet without HIIT (CD), (2) Control Diet with HIIT (CD + HIIT), (3) OO diet (10% kcal from olive oil) without HIIT, and (4) OO diet with HIIT (OO + HIIT). Neither dietary OO or HIIT altered body weight, glucose tolerance, or serum lipids. HIIT, regardless of diet, increased aerobic capacity and HDL cholesterol levels. In liver and heart tissue, OO resulted in similar adaptations as HIIT including increased mitochondrial content and fatty acid oxidation but combining OO with HIIT did not augment these effects. In skeletal muscle, HIIT increased mitochondrial content in type II fibers similarly between diets. An RNA sequencing analysis on type I fibers revealed OO reduced muscle regeneration and lipid metabolism gene abundance, whereas HIIT increased the abundance of these genes, independent of diet. HIIT training, independent of diet, induced subcutaneous white adipose tissue (sWAT) hypertrophy, whereas OO induced gonadal white adipose tissue (gWAT) hypertrophy, an effect that was augmented with HIIT. These data highlight the pleiotropic effects of OO and HIIT, although their combination does not synergize to further improve most markers of health and energy metabolism.(C) 2022 Elsevier Inc. All rights reserved. C1 [Heden, Timothy D.; Chen, Chen; Leland, Grace; Mashek, Mara M.; Najt, Charles P.; Shang, Linshan; Mashek, Douglas G.] Dept Biochem Mol Biol & Biophys, Minneapolis, MN USA. [Chow, Lisa S.; Mashek, Douglas G.] Dept Med, Div Diabet Endocrinol & Metab, Minneapolis, MN USA. [Mashek, Douglas G.] Dept Internal Med, Dept Biochem Mol Biol & Biophys, MCB 7-160,420 Washington Ave SE, Minneapolis, MN 55455 USA. RP Mashek, DG (通讯作者)，Dept Internal Med, Dept Biochem Mol Biol & Biophys, MCB 7-160,420 Washington Ave SE, Minneapolis, MN 55455 USA. EM dmashek@umn.edu RI Mashek, Douglas/ABD-6844-2021; Najt, Charles/PIH-2673-2026; Chow, Lisa/G-8070-2015; Heden, Timothy/IST-7785-2023 OI Mashek, Douglas/0000-0001-7033-3386; Chow, Lisa/0000-0002-6210-2307; Najt, Charles/0000-0001-6455-8810; Heden, Timothy/0000-0003-3977-521X FU NIH [DK114401, 20POST35180115, DK007203, DK109556, DK110338, DK125258]; AHA [AG055452]; National Institute of Diabetes and Digestive and Kidney Diseases [T32DK007203, K01DK125258] Funding Source: NIH RePORTER; National Institute on Aging [R01AG055452] Funding Source: NIH RePORTER; American Heart Association (AHA) [20POST35180115] Funding Source: American Heart Association (AHA) FX Grant support for this project was provided by NIH grants (DK109556, DK110338, DK125258) awarded to T.D.H., NIH grant (DK007203) awarded to C.P.N., NIH grants (AG055452 and DK114401) awarded to D.G.M., AHA grant (19POST34370105) awarded to T.D.H., and AHA grant (20POST35180115) awarded to C.P.N. 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Nutr. Biochem. PD SEP PY 2022 VL 107 AR 109040 DI 10.1016/j.jnutbio.2022.109040 EA JUN 2022 PG 11 WC Biochemistry & Molecular Biology; Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Biochemistry & Molecular Biology; Nutrition & Dietetics GA 2Z7PI UT WOS:000826764600012 PM 35533899 OA Green Submitted DA 2026-02-02 ER PT J AU Lou-Bonafonte, JM Fitó, M Covas, MI Farràs, M Osada, J AF Lou-Bonafonte, Jose M. Fito, Montse Covas, Maria-Isabel Farras, Marta Osada, Jesus TI HDL-Related Mechanisms of Olive Oil Protection in Cardiovascular Disease SO CURRENT VASCULAR PHARMACOLOGY LA English DT Article DE Apolipoprotein; high density lipoprotein; olive oil; cardiovascular risk ID HIGH-DENSITY-LIPOPROTEIN; POLYUNSATURATED FATTY-ACIDS; CORONARY-HEART-DISEASE; APOLIPOPROTEIN-A-I; ATHEROSCLEROTIC LESION DEVELOPMENT; REVERSE CHOLESTEROL TRANSPORT; PLASMA-LIPID CONCENTRATIONS; MEDITERRANEAN-STYLE DIET; ESTER TRANSFER PROTEIN; E-DEFICIENT MICE AB The low incidence of cardiovascular disease in countries bordering the Mediterranean basin, where olive oil is the main source of dietary fat, and the negative association between this disease with high density lipoproteins has stimulated interest. This review summarizes the current knowledge gathered from human and animal studies regarding olive oil and high density lipoproteins. Cumulative evidence suggests that high density lipoprotein (HDL) cholesterol, and its main apolipoprotein A1, may be increased by consuming olive oil when compared with carbohydrate and low fat diets in humans. Conflicting results have been found in many studies when olive oil diets were compared with other sources of fat. The role of virgin olive oil minor components on its protective effect has been demonstrated by a growing number of studies although its exact mechanism remains to be elucidated. Dietary amount of olive oil, use of virgin olive oil, cholesterol intake, and physiopathological states such as genetic background, sex, age, obesity or fatty liver are variables that may offset those effects. Further studies in this field in humans and in animal models are warranted due to the complexity of HDL particles. C1 [Osada, Jesus] Univ Zaragoza, Dept Bioquim & Biol Mol & Celular, Fac Vet, Inst Invest Sanitaria Aragon, Zaragoza, Spain. [Lou-Bonafonte, Jose M.] Univ Zaragoza, Dept Farmacol & Fisiol, Fac Ciencias Salud & Deporte, Zaragoza, Spain. [Fito, Montse; Covas, Maria-Isabel; Farras, Marta] Res Inst Hosp Mar IMIM, Cardiovasc Risk & Nutr Res Grp ULEC CARIN, Res Inflammatory & Cardiovasc Disorders RICAD, Barcelona Biomed Res Pk PRBB, Barcelona, Spain. [Osada, Jesus] Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr, Madrid, Spain. C3 University of Zaragoza; University of Zaragoza; Hospital del Mar Research Institute; Pompeu Fabra University; Barcelona Biomedical Research Park; Instituto de Salud Carlos III; CIBER - Centro de Investigacion Biomedica en Red; CIBEROBN RP Osada, J (通讯作者)，Univ Zaragoza, Dept Bioquim & Biol Mol & Celular, Fac Vet, Inst Invest Sanitaria Aragon, Zaragoza, Spain. EM Josada@unizar.es RI Fitó Colomer, Montse/C-1822-2012; Farràs, Marta/AAA-9418-2021; Lou Bonafonte, José Manuel/E-8282-2014 OI Fitó Colomer, Montse/0000-0002-1817-483X; Farràs Mañé, Marta/0000-0001-9776-3773; Lou Bonafonte, José Manuel/0000-0001-9578-6525 FU CICYT-FEDER [SAF2010-14958, AGL2009-13517-C03-01]; FIS [PI070759]; Gobierno de Aragon [PI025/2008]; Redes FSE-DGA [B-69]; FPI fellowship [BES-2010-040766]; Miguel Servet's contract [CP06/00100] FX We thank Stephanie Lonsdale for help in editing the English text. The work of these authors was supported by grants from CICYT-FEDER (SAF2010-14958 and AGL2009-13517-C03-01), FIS (PI070759), Gobierno de Aragon (PI025/2008), Redes FSE-DGA (B-69), FPI fellowship (BES-2010-040766) and, Miguel Servet's contract (CP06/00100). CIBER de Fisiopatologia de la Obesidad y Nutricion (CIBEROBN) is an initiative of ISCIII. 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Portois, Laurence Malaisse, Willy J. TI n-3 fatty acids and the metabolic syndrome SO AMERICAN JOURNAL OF CLINICAL NUTRITION LA English DT Article; Proceedings Paper CT Symposium on n-3 Fatty Acids - Recommendations for Therapeutics and Prevention CY MAY 21, 2005 CL Columbia Univ, Inst Human Nutr, New York, NY HO Columbia Univ, Inst Human Nutr DE metabolic syndrome; n-3 fatty acids; glucose homeostasis; insulin resistance; diabetes; lipid metabolism; lipoprotein; cardiovascular prevention ID CORONARY-HEART-DISEASE; PURIFIED EICOSAPENTAENOIC ACID; DOCOSAHEXAENOIC ACID; INSULIN-RESISTANCE; FISH-OIL; MUSCLE TRIGLYCERIDE; MEDITERRANEAN DIET; RISK-FACTORS; OMEGA-3-FATTY-ACIDS; PLASMA AB The metabolic syndrome is defined as the coexistence of 3 or more components, some of which indicate alterations in glucose and lipid metabolism. The prevalence of the metabolic syndrome is rapidly increasing in relation to obesity, and it is considered to be an important predictor of cardiovascular disease. Increased intakes or supplements of n-3 marine fatty acids may improve defects in insulin signaling and prevent alterations in glucose homeostasis and the further development of type 2 diabetes. This is largely mediated through a reduction in fatty acid accumulation in muscle and liver. n-3 Polyunsaturated fatty acids (n-3 PUFAs) reduce plasma triacylglycerols and improve the lipoprotein profile by decreasing the fraction of atherogenic small, dense LDL. However, n-3 PUFAs do not lower LDL cholesterol. These effects are likely mediated through the activity of transcription factors relating to expression of genes involved in lipid oxidation and synthesis. Other pleiotrophic effects of n-3 PUFAs may contribute to decreasing the burden of the metabolic syndrome, such as modulating inflammation, platelet activation, endothelial function, and blood pressure. Although studies comparing the effect of both major n-3 PUFAs are limited, docosahexaenoic acid appears at least as efficient as eicosapentaenoic acid in correcting several risk factors. The use of n-3 PUFAs should be considered in more global strategies including changes in lifestyle, such as adhering to a healthy Mediterranean type of diet and practicing regular physical exercise. C1 Univ Libre Bruxelles, L Deloyers Lab Expt Surg, B-1070 Brussels, Belgium. C3 Universite Libre de Bruxelles RP Carpentier, YA (通讯作者)，Univ Libre Bruxelles, L Deloyers Lab Expt Surg, Ave J Wybran 40, B-1070 Brussels, Belgium. 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PD JUN PY 2006 VL 83 IS 6 SU S BP 1499S EP 1504S DI 10.1093/ajcn/83.6.1499S PG 6 WC Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S) SC Nutrition & Dietetics GA 055UY UT WOS:000238477300008 PM 16841860 OA Bronze DA 2026-02-02 ER PT J AU Delarue, J AF Delarue, Jacques TI Beneficial effects of long-chain n-3 fatty acids on insulin-resistance: basic and clinical aspects SO BIOCHIMIE LA English DT Article DE EPA; DHA; Adipose tissue; Type 2 diabetes; Nutrition; Insulin signalling ID ADIPOSE-TISSUE INFLAMMATION; STIMULATED GLUCOSE DISPOSAL; POLYCYSTIC-OVARY-SYNDROME; FISH-OIL SUPPLEMENTATION; SKELETAL-MUSCLE; RESOLVIN D1; DIETARY SUPPLEMENTATION; MACROPHAGE ACCUMULATION; REGIONAL DIFFERENCES; METABOLIC-RESPONSES AB This review aims to provide a comprehensive overview of the available data on the effects of long-chain n-3 polyunsaturated fatty acids (LC n-3 PUFAs) on insulin resistance (IR) associated with noncommunicable diseases (NCDs), including obesity and type 2 diabetes. In recent years, inflammation of adipose tissue (AT) has emerged as a pivotal contributor to IR in these NCDs. Basic studies conducted on isolated adipocytes and rodents consistently demonstrate that LC n-3 PUFAs attenuate AT inflammation through multiple mechanisms. Furthermore, rodent studies have shown that even low doses of LC n-3 PUFAs can effectively prevent IR, particularly when induced by a high-fat diet (HFD). However, trials conducted in humans, using primarily hyperinsulinemic clamp methods, have yielded more varied results, with several studies indicating a sensitising effect on liver and, occasionally, muscle (as assessed by plasma glucose utilisation). In patients with polycystic ovary syndrome (PCOS), gestational diabetes, and metabolic dysfunction-associated steatohepatitis (MASLD), LC n-3 PUFAs have been observed to decrease IR, as measured by the Homeostasis Model Assessment-Insulin Resistance (HOMA-IR) score. In contrast, most meta-analyses of studies conducted in patients with type 2 diabetes (T2D) have concluded to the inefficacy of LC n-3 PUFAs in reducing IR. However, several meta-analyses have identified a protective effect of LC n-3 PUFAs against T2D in Asians, with no heterogeneity observed, contrasting the findings in Western populations, where heterogeneity exists. The most recent analysis and the large UK Biobank cohort have concluded to a protective effect of LC n-3 PUFAs. Therefore, it can be proposed that LC n-3 PUFAs should be administered to individuals with NCD-associated IR and at high risk of T2D, in conjunction with a healthy diet, such as the Mediterranean diet. (c) 2025 The Author. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). C1 [Delarue, Jacques] Univ Brest, Fac Med, ER7479 SPURBO, Brest, France. C3 Universite de Bretagne Occidentale RP Delarue, J (通讯作者)，Fac Med, ER7479 SPURBO, 22 Ave Camille Desmoulins, F-29200 Brest, France. 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10.1016/j.biochi.2025.09.014 EA NOV 2025 PN A PG 11 WC Biochemistry & Molecular Biology WE Science Citation Index Expanded (SCI-EXPANDED) SC Biochemistry & Molecular Biology GA N6350 UT WOS:001631770600004 PM 41016534 OA hybrid DA 2026-02-02 ER PT J AU Alessi, DS Mccreery, CV Zomorrodi, AR AF Alessi, Drew S. Mccreery, Chloe V. Zomorrodi, Ali R. TI In silico dietary interventions using whole-body metabolic models reveal sex-specific and differential dietary risk profiles for metabolic syndrome SO FRONTIERS IN PHYSIOLOGY LA English DT Article DE metabolic syndrome; diet; whole-body models; metabolism; computational modeling ID FATTY-ACID OXIDATION; GLOBAL RECONSTRUCTION; CHOLESTEROL; NUTRITION; LIPOLYSIS; OBESITY; GENDER; HEALTH; CELL AB Metabolic Syndrome (MetS) is a cluster of metabolic disorders that substantially increases the risk of chronic metabolic diseases. Diet plays a crucial role in MetS progression, yet a mechanistic understanding of its impact on MetS risk remains elusive. To address this gap, we conducted a rigorous in silico diet intervention study by leveraging organ-resolved sex-specific whole-body models of metabolism. These models were utilized to computationally evaluate the effect of 12 diverse dietary regimens on key MetS biomarkers-glucose, triacylglycerol, LDL-C, HDL-C-and fatty acid beta-oxidation in representative male and female subjects. Our analyses elucidated molecular mechanisms underlying the link between conventionally unhealthy diets and elevated MetS risk. Specifically, a typical Unhealthy diet indicated elevated triacylglycerol storage in the adipocytes and increased LDL-C to HDL-C ratios across both genders. Conversely, healthier dietary patterns like the Mediterranean, Balanced, and plant-based diets promoted favorable profiles for these biomarkers. Beyond substantiating these known dietary impacts, our analysis also revealed non-intuitive responses to diet. Notably, Vegan and Vegetarian diets induced elevated fatty acid oxidation compared to high-fat regimens like the Ketogenic diet, suggesting their potential in mitigating MetS risk. In addition to these overall trends, pronounced gender differences in metabolic responses to diets were observed, highlighting the need for gender-tailored dietary recommendations. Organ-specific dietary responses and their contributions to MetS biomarkers were also delineated, pinpointing the liver and lungs as major regulators of blood glucose homeostasis. This study contributes to a deeper understanding of the intricate interactions between diet and MetS risk. C1 [Alessi, Drew S.] Boston Univ, Grad Med Sci, Boston, MA USA. [Alessi, Drew S.; Zomorrodi, Ali R.] Massachusetts Gen Hosp, Mucosal Immunol & Biol Res Ctr, Dept Pediat, Boston, MA 02114 USA. [Alessi, Drew S.; Mccreery, Chloe V.; Zomorrodi, Ali R.] Harvard Med Sch, Boston, MA 02115 USA. [Mccreery, Chloe V.] MIT, Dept Bioengn, Boston, MA USA. C3 Boston University; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard Medical School; Massachusetts Institute of Technology (MIT) RP Zomorrodi, AR (通讯作者)，Massachusetts Gen Hosp, Mucosal Immunol & Biol Res Ctr, Dept Pediat, Boston, MA 02114 USA.; Zomorrodi, AR (通讯作者)，Harvard Med Sch, Boston, MA 02115 USA. EM azomorrodi@mgh.harvard.edu FX The author(s) declare that no financial support was received for the research and/or publication of this article. 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Physiol. PD MAY 21 PY 2025 VL 16 AR 1586750 DI 10.3389/fphys.2025.1586750 PG 18 WC Physiology WE Science Citation Index Expanded (SCI-EXPANDED) SC Physiology GA 3MJ2G UT WOS:001503784200001 PM 40470351 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Wali, JA Jarzebska, N Raubenheimer, D Simpson, SJ Rodionov, RN O'Sullivan, JF AF Wali, Jibran A. Jarzebska, Natalia Raubenheimer, David Simpson, Stephen J. Rodionov, Roman N. O'Sullivan, John F. TI Cardio-Metabolic Effects of High-Fat Diets and Their Underlying Mechanisms-A Narrative Review SO NUTRIENTS LA English DT Review DE high-fat diet; saturated fatty acids; metabolism; insulin resistance; obesity; diabetes; mice; cardiovascular disease ID HEPATIC INSULIN-RESISTANCE; NECROSIS-FACTOR-ALPHA; LIFE-STYLE CHANGES; MEDITERRANEAN DIET; CARDIOVASCULAR-DISEASE; MYOCARDIAL-INFARCTION; SKELETAL-MUSCLE; INDUCED OBESITY; HEART-FAILURE; SECONDARY PREVENTION AB The majority of the epidemiological evidence over the past few decades has linked high intake of fats, especially saturated fats, to increased risk of diabetes and cardiovascular disease. However, findings of some recent studies (e.g., the PURE study) have contested this association. High saturated fat diets (HFD) have been widely used in rodent research to study the mechanism of insulin resistance and metabolic syndrome. Two separate but somewhat overlapping models-the diacylglycerol (DAG) model and the ceramide model-have emerged to explain the development of insulin resistance. Studies have shown that lipid deposition in tissues such as muscle and liver inhibit insulin signaling via the toxic molecules DAG and ceramide. DAGs activate protein kinase C that inhibit insulin-PI3K-Akt signaling by phosphorylating serine residues on insulin receptor substrate (IRS). Ceramides are sphingolipids with variable acyl group chain length and activate protein phosphatase 2A that dephosphorylates Akt to block insulin signaling. In adipose tissue, obesity leads to infiltration of macrophages that secrete pro-inflammatory cytokines that inhibit insulin signaling by phosphorylating serine residues of IRS proteins. For cardiovascular disease, studies in humans in the 1950s and 1960s linked high saturated fat intake with atherosclerosis and coronary artery disease. More recently, trials involving Mediterranean diet (e.g., PREDIMED study) have indicated that healthy monounsaturated fats are more effective in preventing cardiovascular mortality and coronary artery disease than are low-fat, low-cholesterol diets. Antioxidant and anti-inflammatory effects of Mediterranean diets are potential mediators of these benefits. C1 [Wali, Jibran A.; Raubenheimer, David; Simpson, Stephen J.; O'Sullivan, John F.] Univ Sydney, Charles Perkins Ctr, Sydney, NSW 2006, Australia. [Wali, Jibran A.; Raubenheimer, David; Simpson, Stephen J.] Univ Sydney, Sch Life & Environm Sci, Fac Sci, Sydney, NSW 2006, Australia. [Jarzebska, Natalia; Rodionov, Roman N.] Tech Univ Dresden, Univ Hosp Carl Gustav Carus, Sect Angiol, Univ Ctr Vasc Med,Dept Med 3, D-01307 Dresden, Germany. [Jarzebska, Natalia] Tech Univ Dresden, Univ Hosp Carl Gustav Carus, Dept Anesthesiol & Intens Care Med, D-01307 Dresden, Germany. [O'Sullivan, John F.] Univ Sydney, Sch Med, Fac Med Sci, Sydney, NSW 2006, Australia. [O'Sullivan, John F.] Univ Sydney, Heart Res Inst, Sydney, NSW 2006, Australia. [O'Sullivan, John F.] Royal Prince Alfred Hosp, Dept Cardiol, Camperdown, NSW 2050, Australia. C3 University of Sydney; University of Sydney; Technische Universitat Dresden; Carl Gustav Carus University Hospital; Technische Universitat Dresden; Carl Gustav Carus University Hospital; University of Sydney; University of Sydney; Heart Research Institute; University of Sydney; NSW Health; Royal Prince Alfred Hospital RP Wali, JA (通讯作者)，Univ Sydney, Sch Life & Environm Sci, Fac Sci, Sydney, NSW 2006, Australia.; O'Sullivan, JF (通讯作者)，Univ Sydney, Sch Med, Fac Med Sci, Sydney, NSW 2006, Australia.; O'Sullivan, JF (通讯作者)，Univ Sydney, Heart Res Inst, Sydney, NSW 2006, Australia.; O'Sullivan, JF (通讯作者)，Royal Prince Alfred Hosp, Dept Cardiol, Camperdown, NSW 2050, Australia. EM jibran.wali@sydney.edu.au; Natalia.Jarzebska@uniklinikum-dresden.de; david.raubenheimer@sydney.edu.au; stephen.simpson@sydney.edu.au; Roman.Rodionov@uniklinikum-dresden.de; john.osullivan@sydney.edu.au RI Wali, Jibran/K-9843-2019; O'Sullivan, John/HLQ-3191-2023; Rodionov, Roman/E-1476-2012; Jarzebska, Natalia/ADM-9204-2022; Simpson, Stephen J/KZU-8465-2024 OI Wali, Jibran/0000-0002-8524-5773; O'Sullivan, John/0000-0001-8016-5128; Raubenheimer, David/0000-0001-9050-1447; Simpson, Stephen J/0000-0003-0256-7687 FU Peter Doherty Biomedical Research Fellowship from the National Health and Medical Research Council of Australia [1125343]; Diabetes Australia [Y17G-WALJ]; NSW Health Early-Mid Career Fellowship [DOH1003]; NSW Clinician-Scientist Award [DOH1006]; National Health and Medical Research Council of Australia [GNT1149976]; National Health and Medical Research Council of Australia [1125343] Funding Source: NHMRC; National Health and Medical Research Council (NHMRC) [1125343] Funding Source: National Health and Medical Research Council (NHMRC) FX J.A. Wali is supported by a Peter Doherty Biomedical Research Fellowship from the National Health and Medical Research Council of Australia (#1125343). This work was supported by a project grant from Diabetes Australia (Y17G-WALJ) awarded to J.A. Wali. J.F. O'Sullivan is supported by a NSW Health Early-Mid Career Fellowship (DOH1003) and a NSW Clinician-Scientist Award (DOH1006). S.J. Simpson and D. Raubenheimer were funded by a Program Grant from the National Health and Medical Research Council of Australia (GNT1149976). 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Hepatic involvement, including hepatic steatosis (HS), is common in both newly diagnosed and long-term GFD-treated CD patients. Limited data exist regarding HS prevalence and risk factors in CD, and the effects of dietary patterns, including GFD and the Mediterranean diet (MD), remain unclear. Objective: This study investigated the prevalence and severity of HS in newly diagnosed, pre-GFD and GFD-treated CD patients compared to non-celiac control subjects, while assessing the influence of dietary adherence. Methods: In a nested cross-sectional study within the ARCTIC trial (NCT05530070), 290 Hungarian adults were enrolled (60 pre-GFD CD, 156 CD on GFD, and 74 control subjects). HS was assessed by ultrasonography, and dietary adherence was evaluated using the Standardized Dietitian Evaluation and Mediterranean Diet Score (MDS). Binary regression models were applied to identify predictors of HS. Results: HS was diagnosed in 34% of participants, most frequently in pre-GFD CD patients. BMI was the strongest predictor of HS both overall and within the CD cohort (OR = 1.27; 95% CI: 1.16, 1.42; p < 0.001). Neither adherence to GFD nor overall MD adherence significantly influenced the prevalence of HS. Severity of HS correlated with higher BMI, older age, and diabetes prevalence, while individual MD components, including olive oil consumption, were associated with milder HS. Conclusions: HS is more prevalent in CD patients, particularly pre-GFD patients, and is strongly associated with BMI. While overall dietary patterns did not significantly impact HS, certain diet components may modulate severity. C1 [Peresztegi, Mira Zsofia; Farkas, Nelli; Vereczkei, Zsofia] Univ Pecs, Inst Translat Med, Med Sch, H-7624 Pecs, Hungary. [Szakacs, Zsolt; Fulop, Petra; Bajor, Judit] Univ Pecs, Med Sch, Dept Med 1, H-7624 Pecs, Hungary. [Farkas, Nelli] Univ Pecs, Inst Bioanal, Med Sch, H-7624 Pecs, Hungary. [Szekeres, Gabor; Faluhelyi, Nandor] Univ Pecs, Med Sch, Dept Med Imaging, H-7624 Pecs, Hungary. [Hagymasi, Krisztina; Dako, Sarolta; Dako, Eszter] Semmelweis Univ, Fac Med, Dept Surg Transplantat & Gastroenterol, H-1082 Budapest, Hungary. [Pasztor, Gyula] Univ Szeged, Albert Szent Gyorgy Hlth Ctr, Dept Radiol, H-6720 Szeged, Hungary. [Vereczkei, Zsofia] Univ Pecs, Inst Nutr Sci & Dietet, Fac Hlth Sci, Dept Sport Nutr & Hydrat, H-7621 Pecs, Hungary. [Lada, Szilvia] Univ Szeged, Albert Szent Gyorgy Hlth Ctr, Directorate Nursing Management & Profess Educ, H-6725 Szeged, Hungary. C3 University of Pecs; University of Pecs; University of Pecs; University of Pecs; Semmelweis University; Szeged University; University of Pecs; Szeged University RP Bajor, J (通讯作者)，Univ Pecs, Med Sch, Dept Med 1, H-7624 Pecs, Hungary. EM peresztegi.mira@pte.hu; szakacs.zsolt@pte.hu; nelli.farkas@aok.pte.hu; gabor.szekeres@pte.hu; nandor.faluhelyi@pte.hu; hagymasi.krisztina@med.semmelweis-univ.hu; pasztor.gyula@szte.hu; vereczkei47@gmail.com; fulop.petra@pte.hu; lada.szilvia@med.u-szeged.hu; dako.sarolta@gmail.com; dako.eszter@phd.semmelweis.hu; bajor.judit@pte.hu RI ; Hagymasi, Krisztina/LXV-2239-2024 OI Lada, Szilvia/0009-0001-9556-4778; Bajor, Judit/0000-0002-3941-4871; Szakács, Zsolt/0000-0002-7035-941X; Vereczkei, Zsófia/0000-0002-8144-4628; Farkas, Nelli/0000-0002-5349-6527 FU University Research Grant Program EKP-25-3-I [EKP-25-3-I-PTE-832]; Ministry of Culture and Innovation, National Fund for Research, Development, and Innovation; University of Pcs Medical School; National Research, Development, and Innovation Office [FK142942] FX This research was funded by the University of Pecs Medical School and by the National Research, Development, and Innovation Office (grant FK142942 to J.B.). This work was also supported by the Ministry of Culture and Innovation, National Fund for Research, Development, and Innovation, under the University Research Grant Program EKOP-25-3-I (EKOP-25-3-I-PTE-832 to M.Z.P.). 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Patients with MetS are at an increased risk of cardiovascular disease, morbidity, and mortality. The coexistence of distinct metabolic abnormalities is associated with the release of pro-inflammatory adipocytokines, as components of low-to-medium grade systemic inflammation and increased oxidative stress. Adopting healthy lifestyles, by using appropriate dietary regimens, contributes to the prevention and treatment of MetS. Metabolic abnormalities can influence the function and energetic capacity of mitochondria, as observed in many obesity-related cardio-metabolic disorders. There are preclinical studies both in cellular and animal models, as well as clinical studies, dealing with distinct nutrients of the Mediterranean diet (MD) and dysfunctional mitochondria in obesity and MetS. The term "Mitochondria nutrients" has been adopted in recent years, and it depicts the adequate nutrients to keep proper mitochondrial function. Different experimental models show that components of the MD, including polyphenols, plant-derived compounds, and polyunsaturated fatty acids, can improve mitochondrial metabolism, biogenesis, and antioxidant capacity. Such effects are valuable to counteract the mitochondrial dysfunction associated with obesity-related abnormalities and can represent the beneficial feature of polyphenols-enriched olive oil, vegetables, nuts, fish, and plant-based foods, as the main components of the MD. Thus, developing mitochondria-targeting nutrients and natural agents for MetS treatment and/or prevention is a logical strategy to decrease the burden of disease and medications at a later stage. In this comprehensive review, we discuss the effects of the MD and its bioactive components on improving mitochondrial structure and activity. C1 [Khalil, Mohamad; Shanmugam, Harshitha; Abdallah, Hala; Britto, Jerlin Stephy John; Galerati, Ilaria; Portincasa, Piero] Univ Bari, Dept Biomed Sci & Human Oncol, Clin Med A Murri, Med Sch, Piazza Giulio Cesare 11, I-70124 Bari, Italy. [Khalil, Mohamad] Univ Bari Aldo Moro, Dept Soil Plant & Food Sci, Via Amendola 165-A, I-70126 Bari, Italy. [Gomez-Ambrosi, Javier; Fruhbeck, Gema] Clin Univ Navarra, Metab Res Lab, Pamplona 31008, Spain. [Gomez-Ambrosi, Javier; Fruhbeck, Gema] ISCIII, CIBER Fisiopatol Obesidad & Nutr CIBEROBN, Pamplona 28029, Spain. [Gomez-Ambrosi, Javier; Fruhbeck, Gema] Inst Invest Sanitaria Navarra IdiSNA, Obes & Adipobiol Grp, Pamplona 31008, Spain. [Fruhbeck, Gema] Clin Univ Navarra, Dept Endocrinol & Nutr, Pamplona 31008, Spain. C3 Universita degli Studi di Bari Aldo Moro; Universita degli Studi di Bari Aldo Moro; University of Navarra; CIBER - Centro de Investigacion Biomedica en Red; CIBEROBN; Instituto de Salud Carlos III; University of Navarra RP Portincasa, P (通讯作者)，Univ Bari, Dept Biomed Sci & Human Oncol, Clin Med A Murri, Med Sch, Piazza Giulio Cesare 11, I-70124 Bari, Italy. EM mohamad.khalil@uniba.it; harshitha.shanmugam@uniba.it; hala.abdallah@uniba.it; jerlin.johnbritto@uniba.it; ilariagalerati@live.it; jagomez@unay.es; gfruhbeck@unay.es; piero.portincasa@uniba.it RI ; Shanmugam, Harshitha/LCE-0958-2024; Khalil, Mohamad/ISA-5550-2023; portincasa, piero/J-7245-2018; Gomez-Ambrosi, Javier/D-2984-2017 OI JohnBritto, Jerlin Stephy/0000-0002-8860-679X; portincasa, piero/0000-0001-5359-1471; Fruhbeck, Gema/0000-0002-8305-7154; Gomez-Ambrosi, Javier/0000-0001-5601-1604 FU European Union's Horizon 2020 Research and Innovation program under the Marie Sklodowska-Curie Grant [722619, 734719]; Grant Regione Puglia [CUP H99C20000340002]; Grant EUROSEEDS Uniba-S56-By-Products Sustainable Recovery 4 Health (BSR-4H): University of Bari Aldo Moro, 2022 FX This paper has been partly supported by funding from the European Union's Horizon 2020 Research and Innovation program under the Marie Sklodowska-Curie Grant Agreement No. 722619 (FOIE GRAS), Grant Agreement No. 734719 (mtFOIE GRAS), Grant Regione Puglia, CUP H99C20000340002 (Fever Apulia), and Grant EUROSEEDS Uniba-S56-By-Products Sustainable Recovery 4 Health (BSR-4H): University of Bari Aldo Moro, 2022. 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Estato, V Bozza, PT Sperandio, M de Castro-Faria-Neto, HC Silva, AR AF Medeiros-de-Moraes, Isabel Matos Goncalves-de-Albuquerque, Cassiano Felippe Kurz, Angela R. M. de Jesus Oliveira, Flora Magno Pereira de Abreu, Victor Hugo Torres, Rafael Carvalho Carvalho, Vinicius Frias Estato, Vanessa Bozza, Patricia Torres Sperandio, Markus de Castro-Faria-Neto, Hugo Caire Silva, Adriana Ribeiro TI Omega-9 Oleic Acid, the Main Compound of Olive Oil, Mitigates Inflammation during Experimental Sepsis SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY LA English DT Article ID ACTIVATED-RECEPTOR-GAMMA; PPAR-GAMMA; FATTY-ACIDS; MEDITERRANEAN DIET; NEUTROPHIL RECRUITMENT; MYOCARDIAL-INFARCTION; BACTERIAL CLEARANCE; LUNG INJURY; KAPPA-B; SURVIVAL AB The Mediterranean diet, rich in olive oil, is beneficial, reducing the risk of cardiovascular diseases and cancer. Olive oil is mostly composed of the monounsaturated fatty acid omega-9. We showed omega-9 protects septic mice modulating lipid metabolism. Sepsis is initiated by the host response to infection with organ damage, increased plasma free fatty acids, high levels of cortisol, massive cytokine production, leukocyte activation, and endothelial dysfunction. We aimed to analyze the effect of omega-9 supplementation on corticosteroid unbalance, inflammation, bacterial elimination, and peroxisome proliferator-activated receptor (PPAR) gamma expression, an omega-9 receptor and inflammatory modulator. We treated mice for 14 days with omega-9 and induced sepsis by cecal ligation and puncture (CLP). We measured systemic corticosterone levels, cytokine production, leukocyte and bacterial counts in the peritoneum, and the expression of PPAR gamma in both liver and adipose tissues during experimental sepsis. We further studied omega-9 effects on leukocyte rolling in mouse cremaster muscle-inflamed postcapillary venules and in the cerebral microcirculation of septic mice. Here, we demonstrate that omega-9 treatment is associated with increased levels of the anti-inflammatory cytokine IL-10 and decreased levels of the proinflammatory cytokines TNF-alpha and IL-1 beta in peritoneal lavage fluid of mice with sepsis. Omega-9 treatment also decreased systemic corticosterone levels. Neutrophil migration from circulation to the peritoneal cavity and leukocyte rolling on the endothelium were decreased by omega-9 treatment. Omega-9 also decreased bacterial load in the peritoneal lavage and restored liver and adipose tissue PPAR gamma expression in septic animals. Our data suggest a beneficial anti-inflammatory role of omega-9 in sepsis, mitigating leukocyte rolling and leukocyte influx, balancing cytokine production, and controlling bacterial growth possibly through a PPAR gamma expression-dependent mechanism. The significant reduction of inflammation detected after omega-9 enteral injection can further contribute to the already known beneficial properties facilitated by unsaturated fatty acid-enriched diets. C1 [Medeiros-de-Moraes, Isabel Matos; Goncalves-de-Albuquerque, Cassiano Felippe; Kurz, Angela R. M.; de Jesus Oliveira, Flora Magno; Estato, Vanessa; Bozza, Patricia Torres; de Castro-Faria-Neto, Hugo Caire; Silva, Adriana Ribeiro] Fiocruz MS, Inst Oswaldo Cruz, Lab Imunofarmacol, Rio De Janeiro, RJ, Brazil. [Goncalves-de-Albuquerque, Cassiano Felippe; Pereira de Abreu, Victor Hugo] Univ Fed Estado Rio de Janeiro, Inst Biomed, Lab Imunofarmacol, Rio De Janeiro, RJ, Brazil. [Kurz, Angela R. M.; Sperandio, Markus] Ludwig Maximilians Univ Munchen, Klinikum Univ, Walter Brendel Ctr, Munich, Germany. [Kurz, Angela R. M.] Centenary Inst, Camperdown, NSW, Australia. [Torres, Rafael Carvalho; Carvalho, Vinicius Frias] Fiocruz MS, Inst Oswaldo Cruz, Lab Inflamacao, Rio De Janeiro, RJ, Brazil. [Sperandio, Markus] Munich Heart Alliance, German Ctr Cardiovasc Res DZHK Partner Site, Munich, Germany. [de Castro-Faria-Neto, Hugo Caire] Univ Estacio Sa, Programa Prod Cient, Rio De Janeiro, RJ, Brazil. C3 Fundacao Oswaldo Cruz; Universidade Federal do Estado do Rio de Janeiro; University of Munich; University of Sydney; Centenary Institute; Fundacao Oswaldo Cruz; German Centre for Cardiovascular Research; Munich Heart Alliance; Universidade Estacio de Sa RP Silva, AR (通讯作者)，Fiocruz MS, Inst Oswaldo Cruz, Lab Imunofarmacol, Rio De Janeiro, RJ, Brazil. EM arsilva71@gmail.com RI Bozza, Patricia/AAE-2933-2021; Ribeiro Silva, Aiana/NBW-8392-2025; Estato, Vanessa/AAJ-9060-2020; Gonçalves-de-Albuquerque, Cassiano Felippe/N-2815-2014; Carvalho, Vinicius/M-4762-2016 OI Bozza, Patricia/0000-0001-8349-9529; Ribeiro Silva, Aiana/0000-0002-5137-4251; Estato, Vanessa/0000-0002-1581-9620; Fontaine, Angela/0000-0002-5032-8026; Pereira de Abreu, Victor Hugo/0000-0001-9027-5929; Gonçalves-de-Albuquerque, Cassiano Felippe/0000-0002-4458-3055; FU Fundacao Carlos Chagas Filho de Amparo a Pesquisa do Estado do Rio de Janeiro (FAPERJ); Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq); Programa Estrategico de Apoio a Pesquisa em Saude (PAPES); Fundacao Oswaldo Cruz; Universidade Federal do Estado do Rio de Janeiro; European Community [HEALTH-F4-2011-282095]; Programa de Produtividade Cientifica da Universidade Estacio de Sa; DFG [SBF14] FX Our work was supported by grants from Fundacao Carlos Chagas Filho de Amparo a Pesquisa do Estado do Rio de Janeiro (FAPERJ), Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq), Programa Estrategico de Apoio a Pesquisa em Saude (PAPES), Fundacao Oswaldo Cruz, and Universidade Federal do Estado do Rio de Janeiro. We also acknowledge financial support by the European Community's Seventh Framework Programme (FP7-2007-2013) under grant agreement HEALTH-F4-2011-282095 (TARKINAID), and Programa de Produtividade Cientifica da Universidade Estacio de Sa. M. S. is supported by DFG grant SBF14, project B01. 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Cell. Longev. PY 2018 VL 2018 AR 6053492 DI 10.1155/2018/6053492 PG 13 WC Cell Biology WE Science Citation Index Expanded (SCI-EXPANDED) SC Cell Biology GA HB6LP UT WOS:000451181500001 PM 30538802 OA Green Submitted, Green Published, hybrid DA 2026-02-02 ER PT J AU Shin, S Ajuwon, KM AF Shin, Sunhye Ajuwon, Kolapo M. TI Effects of Diets Differing in Composition of 18-C Fatty Acids on Adipose Tissue Thermogenic Gene Expression in Mice Fed High-Fat Diets SO NUTRIENTS LA English DT Article DE 18-carbon fatty acids; brown-like phenotype; beige adipocytes; beta-adrenergic stimulation ID ENERGY-EXPENDITURE; LIVER-DISEASE; BEIGE FAT; FISH-OIL; BETA(3)-ADRENERGIC RECEPTORS; 3T3-F442A ADIPOCYTES; MEDITERRANEAN DIET; ARACHIDONIC-ACID; THYROID-HORMONE; DOWN-REGULATION AB Dietary fatty acids play important roles in the regulation of fat accumulation or metabolic phenotype of adipocytes, either as brown or beige fat. However, a systematic comparison of effects of diets with different composition of 18-C fatty acids on browning/beiging phenotype has not been done. In this study, we compared the effects of different dietary fats, rich in specific 18-carbon fatty acids, on thermogenesis and lipid metabolism. Male C57BL/6 mice were fed a control diet containing 5.6% kcal fat from lard and 4.4% kcal fat from soybean oil (CON) or high-fat diets (HFD) containing 25% kcal from lard and 20% kcal fat from shea butter (stearic acid-rich fat; SHB), olive oil (oleic acid-rich oil; OO), safflower oil (linoleic acid-rich oil; SFO), or soybean oil (mixed oleic, linoleic, and -linolenic acids; SBO) ad libitum for 12 weeks, with or without a terminal 4-h norepinephrine (NE) treatment. When compared to SHB, feeding OO, SFO, and SBO resulted in lower body weight gain. The OO fed group had the highest thermogenesis level, which resulted in lower body fat accumulation and improved glucose and lipid metabolism. Feeding SFO downregulated expression of lipid oxidation-related genes and upregulated expression of lipogenic genes, perhaps due to its high n-6:n-3 ratio. In general, HFD-feeding downregulated Ucp1 expression in both subcutaneous and epididymal white adipose tissue, and suppressed NE-induced Pgc1a expression in brown adipose tissue. These results suggest that the position of double bonds in dietary fatty acids, as well as the quantity of dietary fat, may have a significant effect on the regulation of oxidative and thermogenic conditions in vivo. C1 [Shin, Sunhye; Ajuwon, Kolapo M.] Purdue Univ, Interdept Nutr Program, W Lafayette, IN 47907 USA. [Ajuwon, Kolapo M.] Purdue Univ, Dept Anim Sci, W Lafayette, IN 47907 USA. C3 Purdue University System; Purdue University; Purdue University System; Purdue University RP Ajuwon, KM (通讯作者)，Purdue Univ, Interdept Nutr Program, W Lafayette, IN 47907 USA.; Ajuwon, KM (通讯作者)，Purdue Univ, Dept Anim Sci, W Lafayette, IN 47907 USA. EM shin157@purdue.edu; kajuwon@purdue.edu FU Purdue Research Foundation Fellowship; Department of Animal Sciences, Purdue University FX This work was supported by the Department of Animal Sciences, Purdue University and a Purdue Research Foundation Fellowship to S. Shin. 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Gortmaker, Steven L. Hu, Frank B. Kanaya, Alka M. Kandula, Namratha R. Sun, Qi Bhupathiraju, Shilpa N. TI A South Asian Mediterranean-style diet is associated with favorable adiposity measures and lower diabetes risk: The MASALA cohort SO OBESITY LA English DT Article ID CARDIOVASCULAR-DISEASE RISK; PERICARDIAL FAT; ATHEROSCLEROSIS; INDIANS; FOOD; INTERVENTION; PREVALENCE; PATTERNS; AMERICA; HEALTH AB Objective: The Mediterranean diet is associated with lower risks for type 2 diabetes (T2D) and cardiovascular disease in certain populations, although data among diverse groups are limited. This study evaluated cross-sectional and prospective associations between a novel South Asian Mediterranean-style (SAM) diet and cardiometabolic risk among US South Asian individuals. Methods: The study included 891 participants at baseline in the Mediators of Atherosclerosis in South Asians Living in America (MASALA) study. Culturally relevant foods were grouped into nine categories to construct the SAM score. The study examined associations of this score with cardiometabolic risk factors and incident T2D. Results: At baseline, higher adherence to the SAM diet was associated with lower glycated hemoglobin (-0.43% +/- 0.15% per 1-unit increase in SAM score; p = 0.004) and lower pericardial fat volume (-1.22 +/- 0.55 cm(3); p = 0.03), as well as a lower likelihood of obesity (odds ratio [OR]: 0.88, 95% CI: 0.79-0.98) and fatty liver (OR: 0.82, 95% CI: 0.68-0.98). Over the follow-up (similar to 5 years), 45 participants developed T2D; each 1-unit increase in SAM score was associated with a 25% lower odds of incident T2D (OR: 0.75, 95% CI: 0.59-0.95). Conclusions: A greater intake of a SAM diet is associated with favorable adiposity measures and a lower likelihood of incident T2D. C1 [Rai, Sharan K.; Hu, Frank B.; Sun, Qi; Bhupathiraju, Shilpa N.] Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA. [Rai, Sharan K.] Harvard Univ, Grad Sch Arts & Sci, Populat Hlth Sci, Cambridge, MA USA. [Gortmaker, Steven L.] Harvard TH Chan Sch Publ Hlth, Dept Social & Behav Sci, Boston, MA USA. [Hu, Frank B.; Sun, Qi; Bhupathiraju, Shilpa N.] Brigham & Womens Hosp, Channing Div Network Med, Boston, MA USA. [Hu, Frank B.; Sun, Qi; Bhupathiraju, Shilpa N.] Harvard Med Sch, Channing Div Network Med, Boston, MA USA. [Hu, Frank B.; Sun, Qi] Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA. [Kanaya, Alka M.] Univ Calif San Francisco, Dept Med, Div Gen Internal Med, San Francisco, CA USA. [Kandula, Namratha R.] Northwestern Univ, Dept Med, Div Gen Internal Med & Geriatr, Feinberg Sch Med, Chicago, IL USA. [Bhupathiraju, Shilpa N.] Brigham & Womens Hosp, Harvard TH Chan Sch Publ Hlth, Dept Nutr, Channing Div Network Med, Room 338,181 Longwood Ave, Boston, MA 02115 USA. [Bhupathiraju, Shilpa N.] Harvard Med Sch, Harvard TH Chan Sch Publ Hlth, Dept Nutr, Channing Div Network Med, Room 338,181 Longwood Ave, Boston, MA 02115 USA. C3 Harvard University; Harvard T.H. Chan School of Public Health; Harvard University; Harvard University; Harvard T.H. Chan School of Public Health; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard University; Harvard Medical School; Harvard University; Harvard T.H. Chan School of Public Health; University of California System; University of California San Francisco; Northwestern University; Feinberg School of Medicine; Harvard University; Harvard T.H. Chan School of Public Health; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard University; Harvard Medical School; Harvard T.H. Chan School of Public Health RP Bhupathiraju, SN (通讯作者)，Brigham & Womens Hosp, Harvard TH Chan Sch Publ Hlth, Dept Nutr, Channing Div Network Med, Room 338,181 Longwood Ave, Boston, MA 02115 USA.; Bhupathiraju, SN (通讯作者)，Harvard Med Sch, Harvard TH Chan Sch Publ Hlth, Dept Nutr, Channing Div Network Med, Room 338,181 Longwood Ave, Boston, MA 02115 USA. EM nhsnb@channing.harvard.edu RI Sun, Qi/KVY-1113-2024; Hu, Frank/C-1919-2013; Rai, Sharan/HPH-2442-2023 OI Bhupathiraju, Shilpa/0000-0003-0173-9248 FU National Center for Advancing Translational Sciences [UL1TR001872] Funding Source: NIH RePORTER; National Heart Lung and Blood Institute [K24HL112827] Funding Source: NIH RePORTER; National Institute of Diabetes and Digestive and Kidney Diseases [P30DK092924, P30DK098722] Funding Source: NIH RePORTER; NCATS NIH HHS [UL1 TR001872] Funding Source: Medline; NCRR NIH HHS [UL1 RR024131] Funding Source: Medline; NHLBI NIH HHS [K24 HL112827, R01 HL093009] Funding Source: Medline; NIDDK NIH HHS [P30 DK098722, P30 DK092924] Funding Source: Medline CR Ainsworth BE, 1999, J WOMEN HEALTH GEN-B, V8, P805, DOI 10.1089/152460999319129 Al Rifai M, 2018, ATHEROSCLEROSIS, V279, P122, DOI 10.1016/j.atherosclerosis.2018.09.015 Asamane EA, 2019, NUTRIENTS, V11, DOI 10.3390/nu11061224 Bhupathiraju SN, 2022, AM J CLIN NUTR, V116, P1078, DOI 10.1093/ajcn/nqac174 Chiu M, 2010, CAN MED ASSOC J, V182, pE301, DOI 10.1503/cmaj.091676 Deol Rupinder, 2018, Obes Med, V9, P1, DOI [10.1016/j.obmed.2017.11.001, 10.1016/j.obmed.2017.11.001] Evert AB, 2019, DIABETES CARE, V42, P731, DOI 10.2337/dci19-0014 Flowers E, 2019, DIABETES CARE, V42, P946, DOI 10.2337/dc18-1510 Fung TT, 2005, AM J CLIN NUTR, V82, P163 Gadgil MD, 2015, J NUTR, V145, P1211, DOI 10.3945/jn.114.207753 Garg SK, 2016, J AM HEART ASSOC, V5, DOI 10.1161/JAHA.116.004257 Gujral UP, 2013, ANN NY ACAD SCI, V1281, P51, DOI 10.1111/j.1749-6632.2012.06838.x Jin YC, 2018, J NUTR, V148, P1954, DOI 10.1093/jn/nxy217 Kanaya AM, 2010, METAB SYNDR RELAT D, V8, P157, DOI 10.1089/met.2009.0062 Kanaya AM, 2019, J AM HEART ASSOC, V8, DOI [10.1161/JAHA.118.011053, 10.1161/jaha.118.011053] Kanaya AM, 2014, DIABETES CARE, V37, P1621, DOI 10.2337/dc13-2656 Kanaya AM, 2013, CLIN CARDIOL, V36, P713, DOI 10.1002/clc.22219 Kandula NR, 2015, BMC PUBLIC HEALTH, V15, DOI 10.1186/s12889-015-2401-2 Kandula NR, 2014, J AM HEART ASSOC, V3, DOI 10.1161/JAHA.114.001117 Kelemen LE, 2003, J AM DIET ASSOC, V103, P1178, DOI 10.1016/S0002-8223(03)00985-4 Kim TH, 2011, OBESITY, V19, P1028, DOI 10.1038/oby.2010.246 Kodama Y, 2007, AM J ROENTGENOL, V188, P1307, DOI 10.2214/AJR.06.0992 Lawton J, 2008, ETHNIC HEALTH, V13, P305, DOI 10.1080/13557850701882910 Lear SA, 2012, OBESITY, V20, P1293, DOI 10.1038/oby.2011.395 Lim S, 2013, INT J CARDIOL, V169, P166, DOI 10.1016/j.ijcard.2013.08.077 Middleton G, 2015, J NUTR HEALTH AGING, V19, P1019, DOI [10.1007/s12603-015-0663-0, 10.1007/s12603-015-0522-z] Nigam P, 2014, DIABETES TECHNOL THE, V16, P255, DOI 10.1089/dia.2013.0178 Okamura T, 2019, INT J OBESITY, V43, P139, DOI 10.1038/s41366-018-0076-3 Pascoe EA, 2009, PSYCHOL BULL, V135, P531, DOI 10.1037/a0016059 Reddy S, 2015, BIOMED PHARMACOL J, V8, P613, DOI [10.13005/bpj/757, 10.13005/bpj/757, DOI 10.13005/BPJ/757] Ristovski-Slijepcevic S, 2008, APPETITE, V50, P167, DOI 10.1016/j.appet.2007.07.001 Rodrigues YE, 2022, NUTR REV, V80, P1769, DOI 10.1093/nutrit/nuac001 Rosato V, 2019, EUR J NUTR, V58, P173, DOI 10.1007/s00394-017-1582-0 Rosito GA, 2008, CIRCULATION, V117, P605, DOI 10.1161/CIRCULATIONAHA.107.743062 SAALT, 2019, Community resource guide: A demographic snapshot of South Asians in the United States Schwarzfuchs D, 2012, NEW ENGL J MED, V367, P1373, DOI 10.1056/NEJMc1204792 Schwingshackl L, 2017, NUTRIENTS, V9, DOI 10.3390/nu9101063 Schwingshackl L, 2015, PUBLIC HEALTH NUTR, V18, P1292, DOI 10.1017/S1368980014001542 Shah AD, 2016, INT J OBESITY, V40, P639, DOI 10.1038/ijo.2015.219 Shai I, 2008, NEW ENGL J MED, V359, P229, DOI 10.1056/NEJMoa0708681 Singh RB, 2002, LANCET, V360, P1455, DOI 10.1016/S0140-6736(02)11472-3 Sofi F, 2008, BMJ-BRIT MED J, V337, DOI 10.1136/bmj.a1344 Sotos-Prieto M, 2018, NUTRIENTS, V10, DOI 10.3390/nu10030352 Speliotes EK, 2010, HEPATOLOGY, V51, P1979, DOI 10.1002/hep.23593 U.S. Department of Agriculture and U.S, DEP HLTH HUM SERV DI WHO, 2004, LANCET, V363, P902, DOI 10.1016/S0140-6736(03)15268-3 Williams D R, 1997, J Health Psychol, V2, P335, DOI 10.1177/135910539700200305 NR 47 TC 7 Z9 10 U1 2 U2 8 PU WILEY PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 1930-7381 EI 1930-739X J9 OBESITY JI Obesity PD JUN PY 2023 VL 31 IS 6 BP 1697 EP 1706 DI 10.1002/oby.23759 PG 10 WC Endocrinology & Metabolism; Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Endocrinology & Metabolism; Nutrition & Dietetics GA G6VY5 UT WOS:000990524400023 PM 37203330 OA Green Submitted, Bronze DA 2026-02-02 ER PT J AU Frasinariu, OE Lupu, VV Trandafir, LM Streanga, V Jechel, E Bararu-Bojan, I Vasiliu, I Cuciureanu, M Loghin, II Mitrofan, C Nedelcu, AH Knieling, A Lupu, A AF Frasinariu, Otilia Elena Lupu, Vasile Valeriu Trandafir, Laura Mihaela Streanga, Violeta Jechel, Elena Bararu-Bojan, Iris Vasiliu, Ioana Cuciureanu, Magdalena Loghin, Isabela Ioana Mitrofan, Costica Nedelcu, Alin Horatiu Knieling, Anton Lupu, Ancuta TI Metabolic syndrome therapy in pediatric age - between classic and modern. From diets to pipeline drugs SO FRONTIERS IN NUTRITION LA English DT Review DE metabolic syndrome; child; pathophysiology; complementary therapies; lifestyle modification; Mediterranean diet ID FATTY LIVER-DISEASE; INSULIN-RESISTANCE; MEDITERRANEAN DIET; PHYSICAL-ACTIVITY; RISK-ASSESSMENT; CHILDREN; HYPERTENSION; ADOLESCENTS; PREVALENCE; OBESITY AB The metabolic syndrome, made up of the sum of the entities that define it (obesity, hypertension, dyslipidemias and non-alcoholic hepatic steatosis) has gained an important place in the research of the last decades. This aspect is mainly due to the complexity of management in pediatric practice. The main directions in his approach therefore bring together the concern of counteracting the noise or systemic, of the multiple intercurrents at the physiopathological level, as well as the negative imprint exerted on the quality of life. Its appearance and evolution are currently controversial topics, but the influence of genetic predisposition and lifestyle (diet, physical activity, psychological balance) are certainties. Considering the escalation of the incident at the global level, it is self-evident that it is necessary to know the pathogenesis and practice countermeasures for prophylactic or therapeutic purposes. The present work aims to summarize general aspects related to the metabolic syndrome encountered in pediatric age, with an emphasis on complementary therapeutic perspectives and their effectiveness, by analyzing the latest data from the specialized literature, accessed with the help of international databases (e.g., PubMed, Web of Science, Scopus, Embase, Google Scholar). C1 [Frasinariu, Otilia Elena; Lupu, Vasile Valeriu; Trandafir, Laura Mihaela; Streanga, Violeta; Jechel, Elena; Lupu, Ancuta] Grigore T Popa Univ Med & Pharm, Fac Med, Iasi, Romania. [Bararu-Bojan, Iris; Vasiliu, Ioana; Cuciureanu, Magdalena; Loghin, Isabela Ioana; Mitrofan, Costica; Nedelcu, Alin Horatiu; Knieling, Anton] Univ Med & Pharm Grigore T Popa, Fac Med, Iasi, Romania. C3 Grigore T Popa University of Medicine & Pharmacy; Grigore T Popa University of Medicine & Pharmacy RP Streanga, V; Jechel, E (通讯作者)，Grigore T Popa Univ Med & Pharm, Fac Med, Iasi, Romania. 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10.1038/ijo.2008.202 NR 143 TC 0 Z9 0 U1 8 U2 13 PU FRONTIERS MEDIA SA PI LAUSANNE PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND SN 2296-861X J9 FRONT NUTR JI Front. Nutr. PD DEC 11 PY 2024 VL 11 AR 1475111 DI 10.3389/fnut.2024.1475111 PG 17 WC Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Nutrition & Dietetics GA Q1W2O UT WOS:001382666000001 PM 39723164 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Clemente-Suárez, VJ Peris-Ramos, HC Redondo-Flórez, L Beltrán-Velasco, AI Martín-Rodríguez, A David-Fernandez, S Yánez-Sepúlveda, R Tornero-Aguilera, JF AF Clemente-Suarez, Vicente Javier Peris-Ramos, Helia Carmen Redondo-Florez, Laura Beltran-Velasco, Ana Isabel Martin-Rodriguez, Alexandra David-Fernandez, Susana Yanez-Sepulveda, Rodrigo Tornero-Aguilera, Jose Francisco TI Personalizing Nutrition Strategies: Bridging Research and Public Health SO JOURNAL OF PERSONALIZED MEDICINE LA English DT Review DE diet; public health; dietary patterns; dietary behaviors; microbiota; hormonal disruption; inflammation; cardiovascular health; metabolic health; mental health; oncology; dental health; visual health ID FATTY LIVER-DISEASE; GUT MICROBIOTA; MEDITERRANEAN DIET; MENTAL-HEALTH; INSULIN-RESISTANCE; OXIDATIVE STRESS; PANCREATIC-POLYPEPTIDE; MACULAR DEGENERATION; FOOD-INTAKE; WEIGHT-LOSS AB In recent years, although life expectancy has increased significantly, non-communicable diseases (NCDs) continue to pose a significant threat to the health of the global population. Therefore, eating habits have been recognized as key modifiable factors that influence people's health and well-being. For this reason, it is interesting to study dietary patterns, since the human diet is a complex mixture of macronutrients, micronutrients, and bioactive compounds, and can modulate multiple physiological processes, including immune function, the metabolism, and inflammation. To ensure that the data we acquired were current and relevant, we searched primary and secondary sources, including scientific journals, bibliographic indexes, and databases in the last 15 years with the most relevant articles. After this search, we observed that all the recent research on NCDs suggests that diet is a critical factor in shaping an individual's health outcomes. Thus, cardiovascular, metabolic, mental, dental, and visual health depends largely on the intake, habits and patterns, and nutritional behaviors. A diet high in processed and refined foods, added sugars, and saturated fats can increase the risk of developing chronic diseases. On the other hand, a diet rich in whole, nutrient-dense foods, such as vegetables, fruits, nuts, legumes, and a high adherence to Mediterranean diet can improve health's people. C1 [Clemente-Suarez, Vicente Javier; Martin-Rodriguez, Alexandra; Tornero-Aguilera, Jose Francisco] Univ Europea Madrid, Fac Sports Sci, Tajo St S-N, Madrid 28670, Spain. [Clemente-Suarez, Vicente Javier] Univ Costa, Grp Invest Cultura Educ & Sociedad, Barranquilla 080002, Colombia. [Peris-Ramos, Helia Carmen; David-Fernandez, Susana] Univ Europea Madrid, Fac Biomed & Hlth Sci, Clin Odontol Dept, Tajo St S-N, Madrid 28670, Spain. [Redondo-Florez, Laura] Univ Europea Madrid, Fac Biomed & Hlth Sci, Dept Hlth Sci, Tajo St S-N, Villaviciosa de Odon 28670, Spain. [Beltran-Velasco, Ana Isabel] Univ Antonio Nebrija, Educ Dept, Madrid 28240, Spain. [Yanez-Sepulveda, Rodrigo] Univ Andres Bello, Fac Educ & Social Sci, Vina Del Mar 2520000, Chile. C3 European University of Madrid; Universidad de la Costa; European University of Madrid; European University of Madrid; Universidad Antonio de Nebrija; Universidad Andres Bello RP Martín-Rodríguez, A (通讯作者)，Univ Europea Madrid, Fac Sports Sci, Tajo St S-N, Madrid 28670, Spain. EM vctxente@yahoo.es; helia.peris@universidadeuropea.es; lauraredondo_1@hotmail.com; abeltranv@nebrija.es; sandra.martin.rodriguez8@gmail.com; susana.david@universidadeuropea.es; rodrigo.yanez.s@unab.cl; josefranciso.tornero@universidadeuropea.es RI MARTIN-ROIGUEZ, ALEXANA/ISV-0813-2023; Beltrán Velasco, Ana Isabel/J-9381-2019; Yáñez-Sepúlveda, Roigo/HFZ-9707-2022; Clemente-Suárez, Vicente Javier/K-7980-2014; Peris, Helia/OTG-8792-2025 OI MARTIN-ROIGUEZ, ALEXANA/0000-0002-0087-4379; Beltrán Velasco, Ana Isabel/0000-0002-9893-0227; Peris, Helia/0000-0002-1522-3376; Yáñez-Sepúlveda, Roigo/0000-0002-9311-6576; DAVID FERNÁNDEZ, SUSANA/0000-0001-9081-2763; Clemente-Suárez, Vicente Javier/0000-0002-2397-2801; REDONDO FLÓREZ, LAURA/0000-0002-1006-7642 CR ADLERCREUTZ H, 1992, ACTA ONCOL, V31, P175, DOI 10.3109/02841869209088899 ADLERCREUTZ H, 1990, SCAND J CLIN LAB INV, V50, P3, DOI 10.3109/00365519009085798 Agostoni C, 2010, EFSA J, V8, DOI 10.2903/j.efsa.2010.1461 Agrón E, 2021, OPHTHALMOLOGY, V128, P425, DOI 10.1016/j.ophtha.2020.08.018 Aguiló A, 2014, J SPORT SCI, V32, P1659, DOI 10.1080/02640414.2014.912759 Akbari M, 2018, INFLAMMOPHARMACOLOGY, V26, P685, DOI 10.1007/s10787-018-0458-0 Aleksandrova K, 2021, REDOX BIOL, V42, DOI 10.1016/j.redox.2021.101869 Alhabeeb H, 2021, NUTRIENTS, V13, DOI 10.3390/nu13020481 Alkhatib A, 2017, NUTRIENTS, V9, DOI 10.3390/nu9121310 Almoraie NM, 2021, NUTR RES, V91, P81, DOI 10.1016/j.nutres.2021.05.001 Altesha MA, 2019, J CELL PHYSIOL, V234, P5588, DOI 10.1002/jcp.27384 Altun E, 2021, NUTRIENTS, V13, DOI 10.3390/nu13114167 Anand SS, 2015, J AM COLL CARDIOL, V66, P1590, DOI 10.1016/j.jacc.2015.07.050 Anderson EJ, 2009, J CLIN INVEST, V119, P573, DOI 10.1172/JCI37048 Anderson JW, 2009, NUTR REV, V67, P188, DOI 10.1111/j.1753-4887.2009.00189.x Andreoli MF, 2019, J ENDOCRINOL, V241, pR81, DOI 10.1530/JOE-18-0606 [Anonymous], 2012, Med. 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Pers. Med. PD MAR PY 2024 VL 14 IS 3 AR 305 DI 10.3390/jpm14030305 PG 44 WC Health Care Sciences & Services; Medicine, General & Internal WE Science Citation Index Expanded (SCI-EXPANDED) SC Health Care Sciences & Services; General & Internal Medicine GA MI5O1 UT WOS:001193008300001 PM 38541047 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Gunning, JA Converse, MF Gudarzi, B Lotfallah, W Racette, SB AF Gunning, Jordan A. Converse, Madeline F. Gudarzi, Behzad Lotfallah, Wanees Racette, Susan B. TI Dietary Patterns Influence Chronic Disease Risk and Health Outcomes in Older Adults: A Narrative Review SO NUTRIENTS LA English DT Review DE dietary patterns; chronic disease; nutrition; lifestyle; aging; ultra-processed foods; health outcomes; frailty; metabolic health; cognitive function ID CARDIOVASCULAR-DISEASE; INFLAMMATORY INDEX; MEDITERRANEAN DIET; UNITED-STATES; OLIVE OIL; CANCER; MORTALITY; DEMENTIA; MEAT; METAANALYSIS AB The global population is aging rapidly and the prevalence of age-related noncommunicable diseases is increasing. Favorable dietary patterns have the power to reduce the risk or progression of various age-related chronic diseases, including obesity, hypertension, cardiovascular disease, type 2 diabetes, several types of cancer, and some neurodegenerative diseases. In contrast, adverse dietary patterns may contribute to the onset or progression of many chronic diseases or their risk factors. A diet rich in wholesome, nutrient-dense, minimally processed foods, such as a Mediterranean-style diet, may promote health and prevent disease through its abundance of antioxidants, fiber, omega-3 fatty acids, and micronutrients. Conversely, a diet high in nutrient-poor and ultra-processed foods may accelerate disease onset and progression by promoting inflammation and affecting metabolic pathways adversely. This narrative review summarizes the literature from clinical trials and large population-based studies on protective dietary patterns and adverse dietary patterns that influence risk of cardiovascular disease and related risk factors, cancer, Alzheimer's disease and related dementias, type 2 diabetes, frailty, and liver disease. C1 [Gunning, Jordan A.; Converse, Madeline F.; Gudarzi, Behzad; Lotfallah, Wanees; Racette, Susan B.] Arizona State Univ, Coll Hlth Solut, Phoenix, AZ 85004 USA. C3 Arizona State University; Arizona State University-Downtown Phoenix RP Racette, SB (通讯作者)，Arizona State Univ, Coll Hlth Solut, Phoenix, AZ 85004 USA. EM jagunning@asu.edu; bgudarzi@asu.edu; susan.racette@asu.edu RI ; Racette, Susan B/GXV-8800-2022 OI Gunning, Jordan/0009-0002-4212-6958; , Madeline Converse/0009-0001-3689-5147; Gudarzi, Behzad/0000-0003-3718-6083; Racette, Susan B/0000-0002-6932-1887 FU National Institute on Aging and the National Institute of Diabetes and Digestive and Kidney Diseases of the National Institutes of Health [R01AG071717, R33AG070455, R61HL155858, T32DK137525]; Barrow Neurological Foundation FX Support for this work was provided by the National Institute on Aging and the National Institute of Diabetes and Digestive and Kidney Diseases of the National Institutes of Health under Award Numbers R01AG071717, R33AG070455, R61HL155858, and T32DK137525, as well as by Barrow Neurological Foundation. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. 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Attina, Alda Leggeri, Claudia Paroni, Rita Pivari, Francesca Dei Cas, Michele Mingione, Alessandra Dri, Maria Marchetti, Marco Di Renzo, Laura TI Fasting: How to Guide SO NUTRIENTS LA English DT Article DE fasting; starvation; caloric restriction; personalized nutrition; longevity; body composition; diet; Mediterranean model; anti-inflammatory diet ID RANDOMIZED CONTROLLED-TRIAL; DAY CALORIE RESTRICTION; IGF-BINDING PROTEIN-3; FATTY LIVER-DISEASE; DIETARY RESTRICTION; OXIDATIVE STRESS; BODY-COMPOSITION; LIFE-SPAN; MOLECULAR-MECHANISMS; MEDITERRANEAN DIET AB Fasting potentials are the most interesting topics in the Nutritional Era. Fasting consists of the catabolism of lipids, proteins, and carbohydrates to maintain blood glucose levels in a normal range. The action mechanisms of fasting were firstly understood in minor organisms and later in humans. Nutritional interventions of caloric restriction could attenuate age-associated epigenetic alterations and could have a protective effect against cellular alterations, promoting longevity and health span. While most fasting studies point out the weight and fat mass decreases, it is important to define specific guidelines for fasting and non-fasting days to enhance adherence, minimize the dropout rates of the interventions, and maximize body composition improvement. Although the panorama of evidence on fasting and caloric restriction is wide, there is a lack of a safe fasting protocol to guide physicians in its prescription. The main goal is to identify a how to use guide, a major posology of fasting, inserted within a huge dietetic personalized strategy leading to an optimal and healthy nutritional status. C1 [Attina, Alda; Leggeri, Claudia] Univ Roma Tor Vergata, Sch Specializat Food Sci, Via Montpellier 1, I-00133 Rome, Italy. [Paroni, Rita; Pivari, Francesca; Dei Cas, Michele; Mingione, Alessandra] Univ Milan, Dept Hlth Sci, Via A di Rudini 8, I-20142 Milan, Italy. [Dri, Maria; Marchetti, Marco] Univ Roma Tor Vergata, PhD Sch Appl Med Surg Sci, Via Montpellier 1, I-00133 Rome, Italy. [Di Renzo, Laura] Univ Tor Vergata, Sect Clin Nutr & Nutrigen, Dept Biomed & Prevent, Via Montpellier 1, I-00133 Rome, Italy. [Di Renzo, Laura] Univ Tor Vergata, Italian Univ Network Sustainable Dev RUS, Food Working Grp, Via Cracovia, I-00133 Rome, Italy. C3 University of Rome Tor Vergata; University of Milan; University of Rome Tor Vergata; University of Rome Tor Vergata; University of Rome Tor Vergata RP Paroni, R; Pivari, F (通讯作者)，Univ Milan, Dept Hlth Sci, Via A di Rudini 8, I-20142 Milan, Italy. EM alda.attina@gmail.com; claudialeggeri@gmail.com; rita.paroni@unimi.it; francesca.pivari@unimi.it; michele.deicas@unimi.it; alessandra.mingione@unimi.it; DRImarystenr@hotmail.it; marco@marcomarchetti.it; laura.di.renzo@uniroma2.it RI ; PIVARI, FRANCESCA/IQR-9356-2023; PARONI, RITA/AAC-6265-2020; di renzo, laura/ACB-2003-2022; Mingione, Alessana/AAP-8274-2021; Dei Cas, Michele/AAO-2132-2020; Alda, Attinà/GON-7428-2022 OI marchetti, marco/0000-0002-7236-1417; PIVARI, FRANCESCA/0000-0002-2277-6833; PARONI, RITA/0000-0002-3186-8860; di renzo, laura/0000-0001-8875-6723; Mingione, Alessana/0000-0001-8008-0191; Dei Cas, Michele/0000-0001-7359-8558; FU Fondazione Umberto Veronesi FX The authors thank Fulvia Mariotti for English revision. We thank Fondazione Umberto Veronesi for supporting Francesca Pivari whit FUV Post-doc Fellowship Grant 2021. The University of Milan participated in the APC payment for Gold Open Access Journal. 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Verduci, E Berra, C Manfrini, R Banderali, G Giraldi, FP Folli, F AF Tosi, M. Matelloni, I. A. Mancini, M. Andreassi, A. Scopari, A. Rossi, A. Verduci, E. Berra, C. Manfrini, R. Banderali, G. Giraldi, F. Pecori Folli, F. TI Multiple beneficial effects of 1-year nutritional-behavioral intervention on anthropometric and metabolic parameters in overweight and obese boys SO JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION LA English DT Article DE Childhood obesity; Dietary intervention; Healthy Eating Plate; Mediterranean Diet; Fat mass; Transaminase; Insulin resistance; Insulin sensitivity; HOMA index ID FATTY LIVER-DISEASE; INSULIN-RESISTANCE; CHILDHOOD OBESITY; MEDITERRANEAN DIET; LIFE-STYLE; PEDIATRIC GASTROENTEROLOGY; EXPERT COMMITTEE; CHILDREN; ADOLESCENTS; RECOMMENDATIONS AB PurposeChildhood obesity is on the rise worldwide increasing the risk for metabolic, cardiovascular and liver diseases in children. Eating habits and lifestyle changes are currently the standard of care for treating pediatric obesity. Our study aimed to determine the impact of a dietary intervention based on the Mediterranean Diet (MD) and the Health Eating Plate, on anthropometric and metabolic parameters in obese and overweight boys.MethodsWe studied 126 overweight/obese boys with anthropometric measurements, blood biochemistry and nutrient intakes evaluation by means of Food Frequency Questionnaire (FFQ) at baseline, at 6 and 12 months after a nutritional-behavioral intervention.ResultsWe observed a significant reduction in energy, macronutrients and micronutrients intakes. BMI-SDS significantly decreased after 1 year with the proportion of obese boys decreasing by 33% and of overweight boys by 41%, while also all fat mass measures decreased both in obese and overweight individuals. In obese boys, ALT decreased significantly after 1-year nutritional intervention and these changes correlated with BMI-SDS reduction. Insulin-resistance and secretion indexes correlated with fat mass and BMI-SDS. In obese boys, significant changes were observed at 6 months for insulin concentrations, 1/HOMA-IR and QUICKI. With regard to the lipid profile, significant decreases were observed for total and LDL cholesterol in obese boys.ConclusionMetabolic and anthropometric risk factors in overweight and obese boys can be improved by a nutritional-behavioral intervention of 1-year duration. C1 [Tosi, M.; Matelloni, I. A.; Rossi, A.; Verduci, E.; Manfrini, R.; Folli, F.] Univ Milan, Dept Hlth Sci, I-20142 Milan, Italy. [Tosi, M.; Verduci, E.] Univ Milan, Vittore Buzzi Childrens Hosp, Dept Paediat, Milan, Italy. [Mancini, M.; Andreassi, A.; Scopari, A.] Univ Milan, San Paolo Hosp, Dept Pediat, Pediat & Adolescent Androl Unit,ASST Santi Paolo &, I-20142 Milan, Italy. [Berra, C.] IRCCS Multimed, Dept Endocrine & Metab Dis, I-20142 Milan, Italy. [Manfrini, R.; Folli, F.] San Paolo Hosp, ASST Santi Paolo & Carlo, Dept Unit Diabet & Metab Dis, I-20142 Milan, Italy. [Banderali, G.] Univ Milan, San Paolo Hosp, ASST Santi Paolo & Carlo, Dept Pediat, I-20142 Milan, Italy. [Giraldi, F. Pecori] Univ Milan, Dept Clin Sci & Community Hlth, I-20142 Milan, Italy. C3 University of Milan; University of Milan; University of Milan; San Paolo-Polo Universitaria Hospital; IRCCS Multimedica; San Paolo-Polo Universitaria Hospital; University of Milan; San Paolo-Polo Universitaria Hospital; University of Milan RP Folli, F (通讯作者)，Univ Milan, Dept Hlth Sci, I-20142 Milan, Italy.; Folli, F (通讯作者)，San Paolo Hosp, ASST Santi Paolo & Carlo, Dept Unit Diabet & Metab Dis, I-20142 Milan, Italy. EM martina.tosi@unimi.it; irene.matelloni@unimi.it; mario.mancini@asst-santipaolocarlo.it; alice.andreassi@asst-santipaolocarlo.it; andrea.scopari@asst-santipaolocarlo.it; arianna.rossi1@asst-santipaolocarlo.it; elvira.verduci@unimi.it; cesare.berra@multimedica.it; manfrini.roberto@libero.it; giuseppe.banderali@asst-santipaolocarlo.it; francesca.pecorigiraldi@unimi.it; franco.folli@unimi.it RI Tosi, Martina/IAN-6967-2023; Verduci, Elvira/D-7338-2014; folli, franco/J-2795-2018 OI Tosi, Martina/0000-0003-4859-5288; Verduci, Elvira/0000-0003-2111-3111; berra, cesare celeste/0000-0001-8431-8160; folli, franco/0000-0001-9824-5222 CR Al-Beltagi M, 2022, WORLD J DIABETES, V13, P282, DOI 10.4239/wjd.v13.i4.282 [Anonymous], 2015, Global recommendations on physical activity for health [Anonymous], Obesity and overweight Barlow SE, 2007, PEDIATRICS, V120, pS164, DOI 10.1542/peds.2007-2329C Beaglehole R, 2011, LANCET, V377, P1438, DOI 10.1016/S0140-6736(11)60393-0 Bendotti G, 2022, PHARMACOL RES, 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Endocrinol. Invest. PD NOV PY 2023 VL 46 IS 11 BP 2331 EP 2342 DI 10.1007/s40618-023-02088-2 EA APR 2023 PG 12 WC Endocrinology & Metabolism WE Science Citation Index Expanded (SCI-EXPANDED) SC Endocrinology & Metabolism GA U1AQ4 UT WOS:000970727500001 PM 37069323 DA 2026-02-02 ER PT J AU Kumar, M Pal, N Sharma, P Kumawat, M Sarma, DK Nabi, B Verma, V Tiwari, RR Shubham, S Arjmandi, B Nagpal, R AF Kumar, Manoj Pal, Namrata Sharma, Poonam Kumawat, Manoj Sarma, Devojit Kumar Nabi, Bilkees Verma, Vinod Tiwari, Rajnarayan R. Shubham, Swasti Arjmandi, Bahram Nagpal, Ravinder TI Omega-3 Fatty Acids and Their Interaction with the Gut Microbiome in the Prevention and Amelioration of Type-2 Diabetes SO NUTRIENTS LA English DT Review DE diabetes mellitus; gut; omega-3 fatty acids; eicosapentaenoic acid; docosahexaenoic acid; alpha-linolenic acid; microbiota ID POLYUNSATURATED FATTY-ACIDS; INSULIN-RESISTANCE; EICOSAPENTAENOIC ACID; MEDITERRANEAN DIET; HEPATIC STEATOSIS; LIVER-DISEASE; SUPPLEMENTATION; OMEGA-3; MELLITUS; INFLAMMATION AB Type-2 diabetes mellitus (T2DM) is often linked with hyperglycemia, disturbed lipid profiles, inflammation, and gut dysbiosis. Omega-3 fatty acid supplementation has a vital role in the management of T2DM. As a result, a better understanding of the potential role of omega-3 fatty acids in the development and progression of T2DM by influencing the intestinal microflora will help to improve the therapeutic intervention for T2DM and related complications. Focusing on the molecular mechanisms and signaling pathways induced by omega-3 fatty acids, this paper attempts to comprehensively review and discuss the putative associations between omega-3 fatty acids, gut dysbiosis, and the pathophysiology of T2DM and its related comorbidities. In addition, we contemplate the importance of gut microbiota in T2DM prevention and treatment and ponder the role of omega-3 fatty acids in T2DM by positively modulating gut microbiota, which may lead to discovery of novel targets and therapeutic strategies thereby paving way for further comprehensive, mechanistic, and clinical studies. C1 [Kumar, Manoj; Pal, Namrata; Sharma, Poonam; Kumawat, Manoj; Sarma, Devojit Kumar; Tiwari, Rajnarayan R.; Shubham, Swasti] Natl Inst Res Environm Hlth, Bhopal 462030, India. [Nabi, Bilkees] Sam Higginbottom Univ Agr Technol & Sci, Dept Biochem & Biochem Engn, Allahabad 211007, Uttar Pradesh, India. [Verma, Vinod] Sanjay Gandhi Postgrad Inst Med Sci, Stem Cell Res Ctr, Dept Hematol, Lucknow 226014, Uttar Pradesh, India. [Arjmandi, Bahram; Nagpal, Ravinder] Florida State Univ, Dept Nutr & Integrat Physiol, Tallahassee, FL 32302 USA. C3 Indian Council of Medical Research (ICMR); ICMR - National Institute for Research in Environmental Health (NIREH); Sam Higginbottom University of Agriculture, Technology & Sciences; Sanjay Gandhi Postgraduate Institute of Medical Sciences; State University System of Florida; Florida State University RP Arjmandi, B (通讯作者)，Florida State Univ, Dept Nutr & Integrat Physiol, Tallahassee, FL 32302 USA. 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English DT Review ID RAT-LIVER MICROSOMES; FOOD-FREQUENCY QUESTIONNAIRE; TRANS-OCTADECENOIC ACID; CORONARY-HEART-DISEASE; LIQUID INFANT FORMULAS; MATURE HUMAN-MILK; ARACHIDONIC-ACID; GEOMETRICAL-ISOMERS; GAS-CHROMATOGRAPHY; CHOLESTERYL ESTERS AB "Isomeric fatty acids" is a term that refers to the trans- and positional isomers formed during hydrogenation of naturally occurring oils. The purposes of this paper are as follows: (i) to summarize potential exposure of infants to isomeric fatty acids by reviewing estimates of isomeric fatty acids in the maternal diet, in human milk, and in infant formula/infant foods, and (ii) to evaluate the evidence for adverse effects of isomeric fatty acids on infant development with respect to growth, and essential fatty acid status. Estimates of the intake of trans-fatty acids vary widely both within and across populations. Current estimates of trans-fatty acids in the North American population are 4-11% of total fatty acids or 3-13 g/(person(.)d), whereas in Mediterranean countries in which olive oil is the primary fat and in Far Eastern countries in which little commercially hydrogenated fat is consumed, per capita consumption of trans-fatty acids is <1-2 g/d. The trans-fatty acid content of human milk reflects the cross-cultural variation in the maternal diet, with trans-fatty acids in human milk samples ranging from 6 to 7% in North America to <0.5% in Hong Kong. Trans-fatty acids are transferred from the maternal diet through the placenta to the developing fetus or through milk to the breast-fed infant. In some studies, plasma trans-fatty acids are inversely related to birth weight and head circumference. The hypothesis that dietary trans-fatty acids could inhibit biosynthesis of long-chain polyunsaturated fatty acids with 20 and 22 carbon atoms and thus affect infant development is supported by studies demonstrating an inverse correlation of plasma trans-fatty acids with n-3 and n-6 long-chain polyunsaturated fatty acids in infants. However, no such relationship has been observed in human milk. A definitive answer concerning a potentially adverse effect of dietary trans-fatty acids on infant development awaits future studies. 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Barbagallo, Mario TI Mediterranean diet and mitochondria: New findings SO EXPERIMENTAL GERONTOLOGY LA English DT Article DE Mediterranean diet; Mitochondria; Stress; Inflammation; Dementia; Metabolic syndrome ID HUMAN SKELETAL-MUSCLE; POLYUNSATURATED FATTY-ACIDS; HEPATIC STEATOSIS; ADIPOSE-TISSUE; GUT MICROBIOTA; LIVER-DISEASE; STRESS; DYSFUNCTION; BIOGENESIS; MEN AB Mitochondria are subcellular organelles known for their central role in several energetic processes. Accumulating evidence supports a key role for mitochondria in the physiological response to both acute and chronic stress exposure, and, ultimately, the biological embedding of adversity in health and psychological functioning that increases the interest of these organelles in several medical conditions typical of older people. At the same time, Mediterranean diet (MedDiet) seems to affect the function of mitochondria further justifying the role of this diet in lowering the risk of negative health outcomes. In this review, we have elucidated the role of mitochondria in human diseases including the fundamental role in stress, aging, and neuropsychiatric and metabolic disorders. Overall, MedDiet can limit the production of free radicals, being rich in polyphenols. Moreover, MedDiet reduced mitochondrial reactive oxygen species (mtROS) production and ameliorated mitochondrial damage and apoptosis. Similarly, whole grains can maintain the mitochondrial respiration and membrane potential, finally improving mitochondrial function. Other components of MedDiet can have anti-inflammatory effects, again modulating mitochondrial function. For example, delphinidin (a flavonoid present in red wine and berries) restored the elevated level of mitochondrial respiration, mtDNA content, and complex IV activity; similarly, resveratrol and lycopene, present in grapefruits and tomatoes, exerted an anti-inflammatory effect modulating mitochondrial enzymes. Altogether, these findings support the notion that several positive effects of MedDiet can be mediated by a modulation in mitochondrial function indicating the necessity of further studies in human beings for finally confirming these findings. C1 [Pollicino, Francesco; Veronese, Nicola; Dominguez, Ligia J.; Barbagallo, Mario] G DAlessandro PROMISE Univ Palermo, Dept Hlth Promot Maternal & Infant Care, Internal Med & Med Specialties, I-90127 Palermo, Italy. [Dominguez, Ligia J.] Univ Kore Enna, Sch Med & Surg, Enna, Italy. [Veronese, Nicola] Univ Palermo, Dept Internal Med & Geriatr, Geriatr Unit, Via Vespro 141, I-90127 Palermo, Italy. C3 Universita Kore di ENNA; University of Palermo RP Veronese, N (通讯作者)，Univ Palermo, Dept Internal Med & Geriatr, Geriatr Unit, Via Vespro 141, I-90127 Palermo, Italy. 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Gerontol. PD JUN 1 PY 2023 VL 176 AR 112165 DI 10.1016/j.exger.2023.112165 EA APR 2023 PG 10 WC Geriatrics & Gerontology WE Science Citation Index Expanded (SCI-EXPANDED) SC Geriatrics & Gerontology GA F2MM9 UT WOS:000980738100001 PM 37019345 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Guo, JL Han, X Zhan, JC You, YL Huang, WD AF Guo, Jielong Han, Xue Zhan, Jicheng You, Yilin Huang, Weidong TI Vanillin Alleviates High Fat Diet-Induced Obesity and Improves the Gut Microbiota Composition SO FRONTIERS IN MICROBIOLOGY LA English DT Article DE vanillin; obesity; inflammation; gut microbiota; short chain fatty acids ID RED WINE POLYPHENOLS; INSULIN-RESISTANCE; METABOLIC SYNDROME; AKKERMANSIA-MUCINIPHILA; MEDITERRANEAN DIET; BLOOD-PRESSURE; FERULIC ACID; INFLAMMATION; ENDOTOXEMIA; EXTRACT AB Vanillin, a simple phenolic compound, exists marginally in some plants and can be produced by microbes. This study uses high-fat-diet (HFD) induced obese mice to study the effect of vanillin on obesity and obtain positive results. First, both body and adipose tissue weight are reduced. Second, the blood properties signaling certain disorders such as ALT, LDH, glucose, cholesterol, LDL-C, TG and HDL-C are ameliorated and both insulin sensitivity, and glucose tolerance are improved. Third, vanillin reduced elevated levels of inflammatory factors including LPS, IL-6, and TNF-alpha in plasma and liver tissue resulting from obesity. Finally, the production of short chain fatty acids (SCFAs) is enhanced. Additionally, study results demonstrate that vanillin significantly alleviates obesity-related gut microbiota (GM) disorders including the decrease of alpha- and betadiversity. Furthermore, vanillin reduces the abundance of Firmicutes phylum, increases the richness of Bacteroidetes and Verrucomicrobiota phyla, and inhibits the expansion of the lipopolysaccharide (LPS)-producing bacteria Bilophila genus and the H2S-producing bacteria Desulfovibrio genus. C1 [Guo, Jielong; Han, Xue; Zhan, Jicheng; You, Yilin; Huang, Weidong] China Agr Univ, Bejing Key Lab Viticulture & Enol, Coll Food Sci & Nutr Engn, Beijing, Peoples R China. C3 China Agricultural University RP Zhan, JC; You, YL; Huang, WD (通讯作者)，China Agr Univ, Bejing Key Lab Viticulture & Enol, Coll Food Sci & Nutr Engn, Beijing, Peoples R China. EM zhanjicheng@cau.edu.cn; 272197224@qq.com; huanggwd@263.net RI Zhan, Jicheng/ABF-8501-2021 FU National Key Research and Development Program of China [2017YFD0401202]; National Key R&D Program of China [2016YFD0400500] FX This work was supported by The National Key Research and Development Program of China (2017YFD0401202) and National Key R&D Program of China (2016YFD0400500). CR Adams L. 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Microbiol. PD NOV 13 PY 2018 VL 9 AR 2733 DI 10.3389/fmicb.2018.02733 PG 12 WC Microbiology WE Science Citation Index Expanded (SCI-EXPANDED) SC Microbiology GA HA1KD UT WOS:000449970700001 PM 30483238 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Seidita, A Soresi, M Giannitrapani, L Di Stefano, V Citarrella, R Mirarchi, L Cusimano, A Augello, G Carroccio, A Iovanna, JL Cervello, M AF Seidita, Aurelio Soresi, Maurizio Giannitrapani, Lydia Di Stefano, Vita Citarrella, Roberto Mirarchi, Luigi Cusimano, Antonella Augello, Giuseppa Carroccio, Antonio Iovanna, Juan Lucio Cervello, Melchiorre TI The clinical impact of an extra virgin olive oil enriched mediterranean diet on metabolic syndrome: Lights and shadows of a nutraceutical approach SO FRONTIERS IN NUTRITION LA English DT Review DE extra virgin olive oil (EVOO); nutraceuticals; functional foods; metabolic syndrome; cardiovascular disease; insulin resistance ID NONALCOHOLIC FATTY LIVER; ENDOTHELIAL FUNCTION; PHENOLIC-COMPOUNDS; HEPATIC STEATOSIS; OXIDATIVE STRESS; HEALTHY-SUBJECTS; LIPID PROFILE; STYLE DIET; FACTOR-VII; POLYPHENOLS AB For years it has been established that the only truly effective treatment of metabolic syndrome (MS) is lifestyle modification to prevent its cardiovascular (e.g., coronary artery disease and atherosclerosis), metabolic (e.g., diabetes mellitus), and hepatic (e.g., steatosis and non-alcoholic steatohepatitis) complications. The focal points of this approach are to increase physical activity and intake of a diet characterized by high quantities of fruits, vegetables, grains, fish, and low-fat dairy products, the so called mediterranean diet (MD); however, the added value of MD is the presence of extra virgin olive oil (EVOO), a healthy food with a high content of monounsaturated fatty acids, especially oleic acid, and variable concentrations (range 50-800 mg/kg) of phenols (oleuropein, ligstroside, and oleocanthal, and their derivatives, phenolic alcohols, such as hydroxytyrosol and tyrosol). Phenolic compounds not only determine EVOO's main organoleptic qualities (oxidative stability, specific flavor, and taste features) but, theoretically, make it a source of antioxidant, anti-inflammatory, insulin-sensitizing, cardioprotective, antiatherogenic, neuroprotective, immunomodulatory, and anticancer activity. Although many studies have been carried out on EVOO's clinical effects and attention toward this dietary approach (healthy and palatable food with strong nutraceutical activity) has become increasingly pressing, there are still many dark sides to be clarified, both in terms of actual clinical efficacy and biochemical and molecular activity. Thus, we reviewed the international literature, trying to show the state of the art about EVOO's clinical properties to treat MS (along with correlated complications) and the future prospective of its nutraceutical use. C1 [Seidita, Aurelio; Soresi, Maurizio; Giannitrapani, Lydia; Citarrella, Roberto; Mirarchi, Luigi] Univ Palermo, Dept Hlth Promot Sci Maternal & Infant Care Inter, Unit Internal Med, Palermo, Italy. [Giannitrapani, Lydia; Cusimano, Antonella; Augello, Giuseppa; Cervello, Melchiorre] CNR, Inst Biomed Res & Innovat IRIB, Palermo, Italy. [Di Stefano, Vita] Univ Palermo, Dept Biol Chem & Pharmaceut Sci & Technol STEBICE, Palermo, Italy. [Carroccio, Antonio] Osped Riuniti Villa Sofia Cervello, Unit Internal Med, V Cervello Hosp, Palermo, Italy. [Carroccio, Antonio] Univ Palermo, Dept Hlth Promot Sci Maternal & Infant Care Inter, Palermo, Italy. [Iovanna, Juan Lucio] Aix Marseille Univ, CNRS, Inst Paoli Calmettes, Canc Res Ctr Marseille,INSERM,CRCM, Marseille, France. C3 University of Palermo; Consiglio Nazionale delle Ricerche (CNR); Istituto Ricerca l'Innovazione Biomedica (IRIB-CNR); University of Palermo; University of Palermo; UNICANCER; Institut Paoli-Calmette (IPC); Aix-Marseille Universite; Institut National de la Sante et de la Recherche Medicale (Inserm); Centre National de la Recherche Scientifique (CNRS) RP Cervello, M (通讯作者)，CNR, Inst Biomed Res & Innovat IRIB, Palermo, Italy. EM melchiorre.cervello@irib.cnr.it RI Di Stefano, Vita/AFQ-1480-2022; Giannitrapani, Lydia/I-3706-2019; Seidita, Aurelio/IQT-5629-2023; Cervello, Melchiorre/K-5080-2016 OI Di Stefano, Vita/0000-0002-4483-2058; Augello, Giuseppa/0000-0001-6073-2789; Seidita, Aurelio/0000-0003-4080-2641; FU University of Palermo; [08TP1041100162]; [IRIS/U GOV 16463] FX This work was supported in part by the project n. 08TP1041100162 named TRIAL "Code IRIS/U GOV 16463" "PO FESR Sicilia 2014-2020" to LG. Publication costs supported in part by the FFR2021 fund of the University of Palermo assigned to MS. 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Nutr. PD AUG 4 PY 2022 VL 9 AR 980429 DI 10.3389/fnut.2022.980429 PG 13 WC Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Nutrition & Dietetics GA M0LO5 UT WOS:001027117400001 PM 35990331 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Berrichi, M Benammar, C Murtaza, B Hichami, A Belarbi, M Khan, NA AF Berrichi, Meryem Benammar, Chahid Murtaza, Babar Hichami, Aziz Belarbi, Meriem Khan, Naim Akhtar TI Zizyphus lotus L. fruit attenuates obesity-associated alterations: in vivo mechanisms SO ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY LA English DT Article DE Zizyphus lotus L; high-fat diet; obesity; insulin; inflammation ID DIET-INDUCED OBESITY; HIGH-FAT; INSULIN-RESISTANCE; EXPRESSION; INFLAMMATION; POLYPHENOLS; DISEASE; ALPHA; ACID; MICE AB Context: Zizyphus lotus L., ZL is a Mediterranean plant and widely consumed for its beneficial medicinal properties. Objective: We assessed the effects of ZL fruit on diet-induced obesity. Materials and methods: Male C57BL/6j mice were divided into three groups. Each group received either a standard diet or a high-fat diet, HFD (30% of palm oil, w/v) or a HFD-supplemented with ZL fruit powder (10%, w/w) for six weeks, followed by a six weeks period, in which animals were maintained on the HFD and ZL aqueous extract (1%, w/v). We measured plasma parameters and assessed the expression of key genes involved in energy metabolism and inflammation. Results: ZL fruit improved glycaemia, lipids concentrations and inflammation in obese mice. Discussion and conclusion: Our investigations showed that ZL fruit improved glucose tolerance, dyslipidaemia and fatty liver disease, but not the severity of HFD-induced obesity in mice. C1 [Berrichi, Meryem; Murtaza, Babar; Hichami, Aziz; Khan, Naim Akhtar] UBFC, Physiol Nutr & Toxicol NUTox, Agro Sup, UMR U1231,INSERM, Dijon, France. 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PD MAR 4 PY 2021 VL 127 IS 2 BP 119 EP 126 DI 10.1080/13813455.2019.1621349 EA JUN 2019 PG 8 WC Biochemistry & Molecular Biology; Biophysics; Endocrinology & Metabolism; Physiology WE Science Citation Index Expanded (SCI-EXPANDED) SC Biochemistry & Molecular Biology; Biophysics; Endocrinology & Metabolism; Physiology GA RM8OV UT WOS:000471535800001 PM 31155964 DA 2026-02-02 ER PT J AU Zhang, LJ Sui, J Yin, HL Zhao, Q Zhou, YJ Xia, H AF Zhang, Linjie Sui, Jing Yin, Hanlin Zhao, Qun Zhou, Yajie Xia, Hui TI The Impact of the Alternate Mediterranean Diet (aMED) on the Prevention of Chronic Liver Disease: A Meta-Analysis of Observational Studies SO NUTRIENTS LA English DT Review DE chronic liver disease; alternate Mediterranean diet; dietary patterns; meta-analysis; dietary modifications ID HEPATOCELLULAR-CARCINOMA; QUALITY SCORES; RISK; PATTERNS; ASSOCIATION; HEALTH; INDEX; NAFLD AB Conventional research mainly focuses on individual nutrients or specific foods in relation to chronic liver disease, but the cumulative effects of dietary patterns are underexplored. This study aimed to assess current evidence on the alternate Mediterranean Diet (aMED) and chronic liver disease risk via a meta-analysis of observational studies. A systematic search of PubMed, Web of Science, Cochrane, and Embase (up to February 2025) identified studies on aMED and chronic liver disease, using predefined criteria for screening, quality assessment, and data extraction. A total of 20 articles (3 cross-sectional, 15 cohort, and 2 case-control; 1,286,480 participants) were analyzed using a random-effects model. The analysis showed that aMED was significantly negatively correlated with chronic liver disease (OR = 0.65, 95% CI: 0.56-0.75), indicating that adherence reduces risk. Subgroup analysis showed aMED's protective effects in North America (OR = 0.67, 95% CI: 0.54-0.83) and Europe (OR = 0.54, 95% CI: 0.44-0.66). The results suggest aMED adherence may lower chronic liver disease risk, emphasizing dietary modifications for prevention. C1 [Zhang, Linjie; Sui, Jing; Yin, Hanlin; Zhao, Qun] Nanjing Univ Informat Sci & Technol, Res Inst Environm & Hlth, Nanjing 210044, Peoples R China. [Sui, Jing; Xia, Hui] Southeast Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Key Lab Environm Med & Engn,Minist Educ, Nanjing 210009, Peoples R China. [Zhou, Yajie] Zhongke Hlth Ind Grp Co Ltd, Nanjing Zhongke Pharmaceut Co Ltd, Jiangsu Prov Engn Technol Res Ctr Modernizat Tradi, Nanjing 211189, Peoples R China. C3 Nanjing University of Information Science & Technology; Southeast University - China RP Sui, J (通讯作者)，Nanjing Univ Informat Sci & Technol, Res Inst Environm & Hlth, Nanjing 210044, Peoples R China.; Sui, J (通讯作者)，Southeast Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Key Lab Environm Med & Engn,Minist Educ, Nanjing 210009, Peoples R China. EM zhanglinjieedu@163.com; suijing@nuist.edu.cn RI Hanlin, Yin/GQB-4667-2022 OI Sui, Jing/0000-0001-8223-9872; Zhou, Yajie/0009-0001-5450-3354; 张, 琳洁/0009-0008-2929-7385; 尹, seventh7077/0009-0002-0154-7596 FU National Key R&D Program of China; China Postdoctoral Science Foundation [2022M720714]; [2023YFF1104402] FX This research was funded by the National Key R&D Program of China (NO. 2023YFF1104402) and the China Postdoctoral Science Foundation funded project (NO. 2022M720714). 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Kanaka-Gantenbein, Christina TI Mediterranean Diet as an Antioxidant: The Impact on Metabolic Health and Overall Wellbeing SO NUTRIENTS LA English DT Review DE Mediterranean diet; antioxidation; metabolic health; reproductive health; gut microbiota; non-communicable diseases; flavonoids; polyphenols; resveratrol; olive oil ID POLYCYSTIC-OVARY-SYNDROME; GLYCATION END-PRODUCTS; FATTY LIVER-DISEASE; CARDIOVASCULAR-DISEASE; INSULIN-RESISTANCE; GUT MICROBIOTA; GLUCOSE-UPTAKE; INFLAMMATION; POLYPHENOLS; QUERCETIN AB It has been established, worldwide, that non-communicable diseases such as obesity, diabetes, metabolic syndrome, and cardiovascular events account for a high percentage of morbidity and mortality in contemporary societies. Several modifiable risk factors, such as sedentary activities, sleep deprivation, smoking, and unhealthy dietary habits have contributed to this increase. Healthy nutrition in terms of adherence to the Mediterranean diet (MD), rich in fruits, legumes, vegetables, olive oil, herbs, spices, and high fiber intake may contribute to the decrease in this pandemic. The beneficial effects of the MD can be mainly attributed to its numerous components rich in anti-inflammatory and antioxidant properties. Moreover, the MD may further contribute to the improvement of reproductive health, modify the risk for neurodegenerative diseases, and protect against depression and psychosocial maladjustment. There is also evidence highlighting the impact of healthy nutrition in female people on the composition of the gut microbiota and future metabolic and overall health of their offspring. It is therefore important to highlight the beneficial effects of the MD on metabolic, reproductive, and mental health, while shaping the overall health of future generations. The beneficial effects of MD can be further enhanced by increased physical activity in the context of a well-balanced healthy lifestyle. C1 [Gantenbein, Katherina V.; Kanaka-Gantenbein, Christina] Natl & Kapodistrian Univ Athens, Sch Med, Aghia Sophia Childrens Hosp, Div Endocrinol Diabet & Metab,Dept Pediat 1, Athens 11527, Greece. C3 The Aghia Sophia Children's Hospital; National & Kapodistrian University of Athens RP Kanaka-Gantenbein, C (通讯作者)，Natl & Kapodistrian Univ Athens, Sch Med, Aghia Sophia Childrens Hosp, Div Endocrinol Diabet & Metab,Dept Pediat 1, Athens 11527, Greece. 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Jerez, S. Cejas, J. R. Martin, M. V. Acosta, N. G. Bolanos, A. Lorenzo, A. TI Comparative study of lipid and fatty acid composition in different tissues of wild and cultured female broodstock of greater amberjack (Seriola dumerili) SO AQUACULTURE LA English DT Article DE Essential fatty acids; Requirements; Wild; Cultured; Broodstock; Seriola dumerili ID BASS DICENTRARCHUS-LABRAX; BREAM SPARUS-AURATA; ARACHIDONIC-ACID; GILTHEAD SEABREAM; MEDITERRANEAN AMBERJACK; GROWTH-PERFORMANCE; OOCYTE MATURATION; LARVAL QUALITY; EGG QUALITY; FISH-OIL AB The aim of this study was to compare the total lipid (TL) content, the lipid class (LC) composition and their associated fatty acids from muscle, liver and ovary of wild and cultured mature females of greater amberjack (Seriola dumerili), in order to obtain information to formulate a more suitable diet for this species broodstock. TL content in muscle and liver was higher in cultured fish than in wild fish, mainly due to TG accumulation, while the ovary TL content was higher in wild fish. Regarding to fatty acids profile, the percentage of 18:1n-9 in TL and TG was lower in ovaries and muscle of cultured fish than in wild ones. Cultured fish displayed lower proportion of arachidonic acid (20:4n-6, ARA) and higher proportions of 18:2n-6 and eicosapentaenoic acid (20:5n-3, EPA) than wild specimens for all tissues in TL and LC. In contrast, differences in the proportion of docosahexaenoic acid (22:6n-3, DHA) between both groups were found only in some tissues and in some LC, being in those cases higher in wild fish. In consequence, cultured fish presented a lower DHA/EPA ratio and a higher EPA/ARA ratio with respect to wild fish. These results suggest that 18:1n-9, 18:2n-6 and essential fatty acids (EFA), especially EPA and ARA, are not supplied in the appropriate proportions in the diet of cultured fish and could negatively affect their reproductive performance. (C) 2012 Elsevier B.V. All rights reserved. C1 [Rodriguez-Barreto, D.; Acosta, N. G.; Bolanos, A.; Lorenzo, A.] Univ La Laguna, Fac Biol, Dept Biol Anim UDI Fisiol, Santa Cruz De Tenerife 38206, Spain. [Jerez, S.; Cejas, J. R.; Martin, M. V.] Ctr Oceanog Canarias IEO, Inst Espanol Oceanog, Santa Cruz De Tenerife 38120, Spain. C3 Universidad de la Laguna; Spanish Institute of Oceanography RP Lorenzo, A (通讯作者)，Univ La Laguna, Fac Biol, Dept Biol Anim UDI Fisiol, Santa Cruz De Tenerife 38206, Spain. EM alorenhe@ull.es RI Martín, M Virginia/J-1630-2012; Jerez, Salvador/AAB-8894-2020; Cejas, Juana/K-5735-2014; Roiguez Barreto, Deiene/X-2965-2019; Jerez Herrera, Salvador José/AAB-8894-2020 OI Martín, M Virginia/0000-0003-4435-2414; Bolaños, Ana/0000-0002-6175-8582; Acosta González, Nieves Guadalupe/0000-0003-0475-1744; Cejas, Juana/0000-0001-7654-9655; Roiguez Barreto, Deiene/0000-0003-2124-4488; Jerez Herrera, Salvador José/0000-0003-3481-0215 FU Ministerio de Ciencia e Innovacion (MICINN) [AGL2008-05014-C02]; Agencia Canaria de Investigacion, Innovacion y Sociedad de la Informacion (ACIISI); FPU grant from the Spanish Ministerio de Educacion FX This study was supported by the grant from the Ministerio de Ciencia e Innovacion (MICINN) (Ref. AGL2008-05014-C02) and partially from the Agencia Canaria de Investigacion, Innovacion y Sociedad de la Informacion (ACIISI), and Deiene Rodriguez Barreto was supported by a FPU grant from the Spanish Ministerio de Educacion. 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However, the relationship between dietary olive oil intake and liver function in a healthy state of the body remains unclear. Because men are at a greater risk of developing hepatic diseases than women, and because hepatic metabolism is regulated by sex hormones, we hypothesized that olive oil-induced changes in hepatic metabolism would differ by sex. To test our hypothesis, 12-week-old C57BL/6JJcl male and female mice were fed an olive oil diet for 4 weeks. Blood was collected and serum biochemi- cal components were analyzed. Hepatic lipid accumulation was determined via histological analysis using Sudan III staining. Finally, transcript expression levels of hepatic metabolism- related genes were analyzed using quantitative polymerase chain reaction. We observed significant increased hepatic lipid droplet accumulation in olive oil-fed female mice. Serum biochemical and liver messenger RNA expression analyses revealed that the hepatic lipid accumulation was nonpathological and did not involve inflammation. Moreover, the ex- pression of genes related to triacylglycerol and fatty acid synthesis (Dgat1, Dgat2, Agpat3, and Fasn) was significantly upregulated in the liver of olive oil-fed female mice compared with control female mice. Our study demonstrates female-specific hepatic lipid accumula- tion without liver impairment in a dietary olive oil-fed mouse model. These findings provide a deeper mechanistic understanding of sex-dependent hepatic lipid metabolism of dietary oils.(c) 2023 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY license ( http://creativecommons.org/licenses/by/4.0/ ) C1 [Komiya, Yusuke; Ochiai, Masaru; Adachi, Yuto; Yokoyama, Issei; Arihara, Keizo] Kitasato Univ, Sch Vet Med, Dept Anim Sci, Towada, Aomori 0348628, Japan. [Sugiyama, Makoto; Koyama, Chika; Kameshima, Satoshi; Fukasawa, Hanae; Yoshioka, Kazuki] Kitasato Univ, Fac Vet Med, Sch Vet Med, Towada, Aomori 0348628, Japan. C3 Kitasato University; Kitasato University RP Komiya, Y (通讯作者)，Kitasato Univ, Sch Vet Med, Dept Anim Sci, Towada, Aomori 0348628, Japan.; Sugiyama, M (通讯作者)，Kitasato Univ, Fac Vet Med, Sch Vet Med, Towada, Aomori 0348628, Japan. EM komiya@vmas.kitasato-u.ac.jp; masugi@vmas.kitasato-u.ac.jp RI SUGIYAMA, Makoto/KJL-0775-2024; Yokoyama, Issei/PGA-3030-2026; Koyama, Chika/W-1722-2019 OI SUGIYAMA, Makoto/0000-0001-9340-6015; Yokoyama, Issei/0000-0002-1998-0200; Arihara, Keizo/0000-0002-9035-3189; Komiya, Yusuke/0000-0003-3225-2491 FU Grants-in-Aid for Scientific Research [22KJ2827, 23K05096] Funding Source: KAKEN CR Alvarez-Amor L, 2021, SCI REP-UK, V11, DOI 10.1038/s41598-021-87761-3 Bistrian BR, 2003, JPEN-PARENTER ENTER, V27, P168, DOI 10.1177/0148607103027003168 Carr RM, 2016, EXP CELL RES, V340, P187, DOI 10.1016/j.yexcr.2015.10.021 Della Torre S, 2021, NAT COMMUN, V12, DOI 10.1038/s41467-021-27272-x Della Torre S, 2018, CELL METAB, V28, P256, DOI 10.1016/j.cmet.2018.05.021 Dong QM, 2018, BIOL SEX DIFFER, V9, DOI 10.1186/s13293-018-0202-x Duran EM, 2005, FRONT BIOSCI-LANDMRK, V10, P2955, DOI 10.2741/1751 Gao H, 2008, MOL ENDOCRINOL, V22, P10, DOI 10.1210/me.2007-0121 HANSEN AE, 1958, J NUTR, V66, P565, DOI 10.1093/jn/66.4.565 Hashimoto O, 2018, CELL REP, V25, P1193, DOI 10.1016/j.celrep.2018.10.008 Hidalgo-Mora JJ, 2020, NUTRIENTS, V12, DOI 10.3390/nu12103184 Horton JD, 2002, J CLIN INVEST, V109, P1125, DOI 10.1172/JCI200215593 Horton TJ, 1998, J APPL PHYSIOL, V85, P1823, DOI 10.1152/jappl.1998.85.5.1823 Kawahara S, 1997, NUTR RES, V17, P1013, DOI 10.1016/S0271-5317(97)00065-1 Komiya Y, 2021, NUTRIENTS, V13, DOI 10.3390/nu13041164 Lian CY, 2020, CHEM-BIOL INTERACT, V330, DOI 10.1016/j.cbi.2020.109199 Liebig M, 2019, HEPATOBIL SURG NUTR, V8, P447, DOI 10.21037/hbsn.2019.04.03 Loft A, 2021, CELL METAB, V33, P1685, DOI 10.1016/j.cmet.2021.06.005 Lonardo A, 2019, HEPATOLOGY, V70, P1457, DOI 10.1002/hep.30626 Mauvais-Jarvis F, 2015, BIOL SEX DIFFER, V6, DOI 10.1186/s13293-015-0033-y Nigam P, 2014, DIABETES TECHNOL THE, V16, P255, DOI 10.1089/dia.2013.0178 Palmisano BT, 2017, ADV EXP MED BIOL, V1043, P227, DOI 10.1007/978-3-319-70178-3_12 Pettinelli P, 2011, J CLIN ENDOCR METAB, V96, P1424, DOI 10.1210/jc.2010-2129 Sánchez-Calvo B, 2021, J NUTR BIOCHEM, V94, DOI 10.1016/j.jnutbio.2021.108646 Sugiyama M, 2021, BIOL REPROD, V105, P1272, DOI 10.1093/biolre/ioab157 Sugiyama M, 2021, CELL TISSUE RES, V383, P1183, DOI 10.1007/s00441-020-03310-w Sweet PH, 2017, PRIMARY CARE, V44, P599, DOI 10.1016/j.pop.2017.07.003 Tramunt B, 2020, DIABETOLOGIA, V63, P453, DOI 10.1007/s00125-019-05040-3 Trefts E, 2017, CURR BIOL, V27, pR1147, DOI 10.1016/j.cub.2017.09.019 Uchida K, 2021, NUTRITION, V85, DOI 10.1016/j.nut.2020.111130 Villa A, 2012, P NATL ACAD SCI USA, V109, P11806, DOI 10.1073/pnas.1205797109 Wallis JG, 2002, TRENDS BIOCHEM SCI, V27, P467, DOI 10.1016/S0968-0004(02)02168-0 Yamanaka W K, 1980, Prog Lipid Res, V19, P187, DOI 10.1016/0163-7827(80)90004-1 Yki-Järvinen H, 2021, NAT REV GASTRO HEPAT, V18, P770, DOI 10.1038/s41575-021-00472-y Zhang YJ, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0023506 NR 35 TC 3 Z9 3 U1 1 U2 7 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0271-5317 EI 1879-0739 J9 NUTR RES JI Nutr. Res. PD APR PY 2023 VL 112 BP 11 EP 19 DI 10.1016/j.nutres.2023.02.001 EA MAR 2023 PG 9 WC Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Nutrition & Dietetics GA A3BN3 UT WOS:000953919100001 PM 36934523 OA hybrid DA 2026-02-02 ER PT J AU Chassot, LN Scolaro, B Roschel, GG Cogliati, B Cavalcanti, MF Abdalla, DSP Castro, IA AF Chassot, Livia N. Scolaro, Bianca Roschel, Gabriela G. Cogliati, Bruno Cavalcanti, Marcela F. Abdalla, Dulcineia S. P. Castro, Inar A. TI Comparison between red wine and isolated trans-resveratrol on the prevention and regression of atherosclerosis in LDLr (-/-) mice SO JOURNAL OF NUTRITIONAL BIOCHEMISTRY LA English DT Article DE Red wine; Trans-resveratrol; Atherosclerosis; Mice; Oxidative stress ID LOW-DENSITY-LIPOPROTEIN; OXIDATIVE STRESS; REDUCES ATHEROSCLEROSIS; PHENOLIC-COMPOUNDS; IN-VITRO; PLASMA; POLYPHENOLS; LIVER; SUPPLEMENTATION; BIOAVAILABILITY AB Moderate consumption of red wine has been widely associated with reduced cardiovascular risk, mainly due to its composition in phenolic compounds with antioxidant activity, such as resveratrol. The objective of this study was to compare the effect of red wine vs. trans-resveratrol consumption on the prevention and regression of atherosclerosis in LDLr ((-/-)) mice. This study consisted of two protocols: "Prevention" (PREV) and "Regression" (REGR). Both protocols included four groups: red wine (WINE), dealcoholized red wine (EXT), trans-resveratrol (RESV), and control (CONT). In PREV protocol, animals received a regular diet for 8 weeks and then switched to an atherogenic diet for the following 8 weeks, while the opposite was performed in REGR. Animals that received atherogenic diet after an initial period of standard diet (PREV) gained more body weight (39.25 +/- 230%) than the opposite (29.27 +/- 1.91%, P=.0013), suggesting an interaction between age and weight gain. Trans-resveratrol showed the highest hypocholesterolemic effect during PREV, reducing total cholesterol, LDL-C, VLDL-C and HDL-C. Supplementation with trans-resveratrol and dealcoholized red wine changed the fatty acids profile in the liver in both protocols, leading to an increase of MDA concentrations and SOD activity in the PREV protocol. In conclusion, supplementation with trans-resveratrol, red wine and the same wine without alcohol altered biomarkers of oxidative stress and lipidemia but had no effect on the prevention or regression of fatty streaks. These data suggest that cardiovascular protection associated with the "French Paradox" may be a result of synergistic effects between wine and the Mediterranean diet. (C) 2018 Elsevier Inc. All rights reserved. C1 [Chassot, Livia N.; Scolaro, Bianca; Roschel, Gabriela G.; Castro, Inar A.] Univ Sao Paulo, Fac Pharmaceut Sci, Dept Food & Expt Nutr, LADAF, Av Lineu Prestes 580,B14, BR-05508000 Sao Paulo, Brazil. [Cogliati, Bruno] Univ Sao Paulo, Sch Vet Med & Anim Sci, Dept Pathol, Av Prof Dr Orlando Marques de Paiva 87, BR-05508270 Sao Paulo, Brazil. [Cavalcanti, Marcela F.; Abdalla, Dulcineia S. P.] Univ Sao Paulo, Fac Pharmaceut Sci, Dept Clin Anal DSPA, Sao Paulo, Brazil. C3 Universidade de Sao Paulo; Universidade de Sao Paulo; Universidade de Sao Paulo RP Castro, IA (通讯作者)，Univ Sao Paulo, Dept Food & Expt Nutr, Fac Pharmaceut Sci, Av Lineu Prestes 580,B14, BR-05508900 Sao Paulo, Brazil. EM inar@usp.br RI Cogliati, Bruno/E-9956-2012; Roschel, Gabriela/AAS-5676-2021; Castro, Inar/C-4923-2012; Scolaro, Bianca/C-9973-2014 OI Cogliati, Bruno/0000-0002-1388-7240; Scolaro, Bianca/0000-0001-6436-8435 FU Fundacao de Amparo Pesquisa do Estado de Sao Paulo (FAPESP) [16/11664-5]; Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq); Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [16/11664-5] Funding Source: FAPESP FX This study was financially supported by Fundacao de Amparo Pesquisa do Estado de Sao Paulo (FAPESP; Process 16/11664-5) and Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq). Funding sources had no role in the design, execution, analyses or interpretation of study data, nor decision to submit results of this study. 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Nutr. Biochem. PD NOV PY 2018 VL 61 BP 48 EP 55 DI 10.1016/j.jnutbio.2018.07.014 PG 8 WC Biochemistry & Molecular Biology; Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Biochemistry & Molecular Biology; Nutrition & Dietetics GA HC4RE UT WOS:000451791100006 PM 30184518 DA 2026-02-02 ER PT J AU Ratziu, V AF Ratziu, Vlad TI Metabolic cirrhosis: An emerging entity SO BULLETIN DE L ACADEMIE NATIONALE DE MEDECINE LA English DT Article DE Non-alcoholic fatty liver disease; Liver cirrhosis; Carcinoma; Hepatocellular; Liver neoplasms; Biomarkers; Obesity; Diabetes mellitus ID NONALCOHOLIC FATTY LIVER; BODY-MASS INDEX; TERM-FOLLOW-UP; HEPATOCELLULAR-CARCINOMA; NATURAL-HISTORY; CANCER-RISK; CRYPTOGENIC CIRRHOSIS; DIABETES-MELLITUS; ALCOHOLIC HEPATITIS; MEDITERRANEAN DIET AB Since the first description of non-alcoholic steatohepatitis in 1981 considerable progress have led to its individualization as a frequent and potentially serious liver disease. The identification of insulin resistance as a major factor in steatogenesis, and possibly in the progression of liver disease, has prompted screening for liver fibrosis in individuals with metabolic risk factors. Evidence that steatohepatitis can coexist with other liver diseases exacerbating liver fibrosis has reinforced its status as an independent liver disease, no longer requiring the exclusion of other chronic liver conditions. The frequent occurrence of cirrhosis as an independent cause of death in these patients, along with the risks of hepatocellular carcinoma and elevated liver and cardiovascular mortality underscores the disease's severity. With the declining use of liver biopsy in clinical practice, non-invasive tests have taken center-stage in the recognition of progressive forms of the disease and risk prediction. There is now significant therapeutic effort focused on developing pharmacological agents to control metabolic dysfunction and address hepatic inflammation and fibrogenesis. Future therapeutic strategies should aim to optimize long-term maintenance of dietary and life-style changes while integrating these efforts with liver-targeted pharmacological treatments. (c) 2024 l'Academie nationale de medecine. Published by Elsevier Masson SAS. All rights are reserved, including those for text and data mining, AI training, and similar technologies. C1 [Ratziu, Vlad] Sorbonne Univ, AP HP, IHU ICAN, Paris, France. [Ratziu, Vlad] Hop La Pitie Salpetriere, INSERM, UMRS 893, 47-83 Blvd Hop, F-75013 Paris, France. C3 Assistance Publique Hopitaux Paris (APHP); Institut National de la Sante et de la Recherche Medicale (Inserm); Sorbonne Universite; Assistance Publique Hopitaux Paris (APHP); Hopital Universitaire Pitie-Salpetriere - APHP; Sorbonne Universite; Institut National de la Sante et de la Recherche Medicale (Inserm) RP Ratziu, V (通讯作者)，Sorbonne Univ, AP HP, IHU ICAN, Paris, France.; Ratziu, V (通讯作者)，Hop La Pitie Salpetriere, INSERM, UMRS 893, 47-83 Blvd Hop, F-75013 Paris, France. 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Acad. Natl. Med. PD JAN PY 2025 VL 209 IS 1 BP 62 EP 73 DI 10.1016/j.banm.2024.11.012 EA JAN 2025 PG 12 WC Medicine, General & Internal WE Science Citation Index Expanded (SCI-EXPANDED) SC General & Internal Medicine GA S5D2J UT WOS:001398418500001 OA hybrid DA 2026-02-02 ER PT J AU Singh, RB Gupta, S Dherange, P De Meester, F Wilczynska, A Alam, SE Pella, D Wilson, DW AF Singh, Ram B. Gupta, Siddharth Dherange, Parinita De Meester, Fabien Wilczynska, Agnieszka Alam, Shaan E. Pella, Daniel Wilson, Douglas W. TI Metabolic syndrome: a brain disease SO CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY LA English DT Review DE hypothalamus; glucose intolerance; insulin resistance; brain disease; diet; nutrition; omega-3 fatty acids; brain development; brain-heart connection; Mediterranean diet ID POLYUNSATURATED FATTY-ACIDS; CORONARY-ARTERY DISEASE; INSULIN-RECEPTOR; BLOOD-PRESSURE; ARCUATE NUCLEUS; TNF-ALPHA; RISK-FACTORS; VAGUS NERVE; ACETYLCHOLINE; RELEASE AB Recent research indicates an association between brain dysfunction and the pathogenesis of metabolic syndrome. To investigate this, we created a Medline search (up to December 2011) of articles in PubMed. The results indicated that refined carbohydrates, saturated and total fat, high levels of omega-6 fatty acids, and low levels of omega-3 fatty acids and other long chain polyunsaturated fatty acids (PUFA), all in conjunction with sedentary behaviour and mental stress can predispose to inflammation. Increased sympathetic activity, with increased secretion of catecholamine, cortisol, and serotonin can cause oxidative stress, which may damage the arcuate nucleus as well as the hypothalamus and macrophages, and the liver may release pro-inflammatory cytokines. These, in conjunction with an underlying deficiency in long chain PUFA, may damage the arcuate nucleus as well as neuropeptide-Y and pro-opiomelanocortin neurons and insulin receptors in the brain, especially during fetal life, infancy, and childhood, resulting in their dysfunction. Of the fatty acids in the brain, 30%-50% are long chain PUFA, which are incorporated in the cell membrane phospholipids. Hence, omega-3 fatty acids, which are also known to enhance parasympathetic activity and increase the secretion of anti-inflammatory cytokines interleukin (IL)-4 and IL-10 as well as acetylcholine in the hippocampus, may be protective. Therefore, treatment with omega-3 fatty acids may be applied for the prevention of metabolic syndrome. C1 [Singh, Ram B.; Gupta, Siddharth; Dherange, Parinita; De Meester, Fabien; Wilczynska, Agnieszka] TsimTsoum Inst, PL-40126 Krakow, Silesia, Poland. [Alam, Shaan E.] Univ Coll Med Sci, Delhi 190095, India. [Pella, Daniel] PJ Safaric Univ, Interna Klin FNSP, Dept Med 3, Kosice 04011, Slovakia. [Wilson, Douglas W.] Sch Med & Hlth, Durham TS17 6BH, England. C3 University of Delhi; University College of Medical Sciences RP Singh, RB (通讯作者)，TsimTsoum Inst, Golebia St, PL-40126 Krakow, Silesia, Poland. 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PD SEP PY 2012 VL 90 IS 9 BP 1171 EP 1183 DI 10.1139/Y2012-122 PG 13 WC Pharmacology & Pharmacy; Physiology WE Science Citation Index Expanded (SCI-EXPANDED) SC Pharmacology & Pharmacy; Physiology GA 997GI UT WOS:000308152200004 PM 22913633 DA 2026-02-02 ER PT J AU Muscogiuri, G Barrea, L Cantone, MC Guarnotta, V Mazzilli, R Verde, L Vetrani, C Colao, A Faggiano, A AF Muscogiuri, Giovanna Barrea, Luigi Cantone, Maria Celeste Guarnotta, Valentina Mazzilli, Rossella Verde, Ludovica Vetrani, Claudia Colao, Annamaria Faggiano, Antongiulio CA NIKE TI Neuroendocrine Tumors: A Comprehensive Review on Nutritional Approaches SO CANCERS LA English DT Review DE neuroendocrine neoplasms; neuroendocrine tumors; cancer; diet; Mediterranean diet; ketogenic diet; fasting ID METABOLICALLY SUPPORTED CHEMOTHERAPY; ENETS CONSENSUS GUIDELINES; HYPERBARIC-OXYGEN THERAPY; CHAIN FATTY-ACIDS; MEDITERRANEAN DIET; KETOGENIC DIET; CALORIC RESTRICTION; BREAST-CANCER; COLORECTAL-CANCER; WEIGHT-LOSS AB Simple Summary Neuroendocrine neoplasms and their main subtype neuroendocrine tumors have an increasing incidence worldwide, associated with a high survival and prevalence rate. Both the tumor itself and systemic therapy can have an impact on patients' nutrition. Conversely, preliminary data suggest that malnutrition has a negative impact on the development and prognosis of neuroendocrine tumors, as does obesity. The aim of this review is to condense the latest evidence on the role of the most widely used dietary patterns, the Mediterranean diet, the ketogenic diet and intermittent fasting, in the context of neuroendocrine tumors. Nutritional plans are an integral part of the multidisciplinary treatment team of patients with neuroendocrine tumors because they improve the patient's quality of life. The nutritional approach must be tailored, based on nutritional needs and nutritionally manageable signs and/or symptoms related to drug treatment. Neuroendocrine neoplasms are a heterogeneous group of neoplasms with increasing incidence, high prevalence, and survival worldwide. About 90% of cases are well differentiated forms, the so-called neuroendocrine tumors (NETs), with slow proliferation rates and prolonged survival but frequent development of liver metastases and endocrine syndromes. Both the tumor itself and systemic therapy may have an impact on patient nutrition. Malnutrition has a negative impact on outcome in patients with NETs, as well as obesity. In addition, obesity and metabolic syndrome have been shown to be risk factors for both the development and prognosis of NET. Therefore, dietary assessment based on body composition and lifestyle modifications should be an integral part of the treatment of NET patients. Nutrition plans, properly formulated by a dietician, are an integral part of the multidisciplinary treatment team for patients with NETs because they allow an improvement in quality of life, providing a tailored approach based on nutritional needs and nutritional manageable signs and/or symptoms related to pharmacological treatment. The aim of this review is to condense the latest evidence on the role of the most used dietary models, the Mediterranean diet, the ketogenic diet, and intermittent fasting, in the context of NETs, while considering the clinical and molecular mechanisms by which these dietary models act. C1 [Muscogiuri, Giovanna; Barrea, Luigi; Verde, Ludovica; Colao, Annamaria] Univ Federico II, Dipartimento Med Clin & Chirurg, Unita Endocrinol, Ctr Italiano Cura Benessere Paziente Con Obesita, I-80131 Naples, Italy. [Muscogiuri, Giovanna; Vetrani, Claudia; Colao, Annamaria] Univ Federico II, Dipartimento Med Clin Chirurg, Unita Endocrinol Diabetol & Androl, I-80131 Naples, Italy. [Muscogiuri, Giovanna; Vetrani, Claudia; Colao, Annamaria] Univ Federico II, Cattedra Unesco Educ Salute & Sviluppo Sostenibil, I-80131 Naples, Italy. [Barrea, Luigi] Univ Telemat Pegaso, Dipartimento Sci Umanistiche, Via Porzio,Ctr Direz,Isola F2, I-80143 Naples, Italy. [Cantone, Maria Celeste] Univ Milan, Dept Med Biotechnol & Translat Med BIOMETRA, I-20157 Milan, Italy. [Guarnotta, Valentina] Univ Palermo, Sez Malattie Endocrine Ricambio & Nutr, Dipartimento Promoz Salute Maternoinfantile Med 1, I-90127 Palermo, Italy. [Mazzilli, Rossella; Faggiano, Antongiulio] Sapienza Univ Rome, St Andrea Hosp, Dept Clin & Mol Med, I-00185 Rome, Italy. C3 University of Naples Federico II; University of Naples Federico II; University of Naples Federico II; Pegaso Online University; University of Milan; University of Palermo; Sapienza University Rome; Azienda Ospedaliera Sant'Andrea RP Muscogiuri, G (通讯作者)，Univ Federico II, Dipartimento Med Clin & Chirurg, Unita Endocrinol, Ctr Italiano Cura Benessere Paziente Con Obesita, I-80131 Naples, Italy.; Muscogiuri, G (通讯作者)，Univ Federico II, Dipartimento Med Clin Chirurg, Unita Endocrinol Diabetol & Androl, I-80131 Naples, Italy.; Muscogiuri, G (通讯作者)，Univ Federico II, Cattedra Unesco Educ Salute & Sviluppo Sostenibil, I-80131 Naples, Italy. EM giovanna.muscogiuri@unina.it RI Barrea, Luigi/K-6551-2016; Faggiano, Antongiulio/ABC-4819-2020; Vetrani, Claudia/D-3306-2018; Verde, Ludovica/AHB-4097-2022; Colao, Annamaria/A-7671-2011; Cantone, Maria Celeste/ABD-8852-2021; Muscogiuri, Giovanna/K-5817-2016; Mazzilli, Rossella/S-4109-2019 OI Barrea, Luigi/0000-0001-9054-456X; Faggiano, Antongiulio/0000-0002-9324-3946; Vetrani, Claudia/0000-0001-8335-5939; Verde, Ludovica/0000-0002-4583-8283; CR Abenavoli L, 2021, MINERVA ENDOCRINOL, V46, P371, DOI 10.23736/S2724-6507.21.03644-7 Adeva-Andany MM, 2019, J CLIN TRANSL ENDOCR, V15, P45, DOI 10.1016/j.jcte.2018.12.005 Agnoli C, 2013, INT J CANCER, V132, P1404, DOI 10.1002/ijc.27740 Almodallal Y, 2021, MEDICINE, V100, DOI 10.1097/MD.0000000000028033 Altieri B, 2018, REV ENDOCR METAB DIS, V19, P159, DOI 10.1007/s11154-018-9466-z Aly SM, 2014, INT J HEALTH SCI-IJH, V8, pV, DOI 10.12816/0023985 Amer Diabet Assoc, 2021, DIABETES CARE, V44, pS111, DOI 10.2337/dc21-S009 Amor Souheila, 2018, 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Lipovich, Leonard Ho, Samuel B. TI Dietary Patterns and Associated Microbiome Changes that Promote Oncogenesis SO FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY LA English DT Review DE microbiome; dietary pattern; Western diet; plant-based diet; colorectal cancer; alcohol; oncogenesis ID TRIMETHYLAMINE-N-OXIDE; COLORECTAL-CANCER CELLS; CHAIN FATTY-ACIDS; FUSOBACTERIUM-NUCLEATUM; GUT MICROBIOTA; INTESTINAL MICROBIOTA; MEDITERRANEAN DIET; MUCUS BARRIER; BREAST-CANCER; LIVER-CANCER AB The recent increases in cancer incidences have been linked to lifestyle changes that result in obesity and metabolic syndrome. It is now evident that these trends are associated with the profound changes that occur in the intestinal microbiome, producing altered microbial population signatures that interact, directly or indirectly, with potentially pro-carcinogenic molecular pathways of transcription, proliferation, and inflammation. The effects of the entire gut microbial population on overall health are complex, but individual bacteria are known to play important and definable roles. Recent detailed examinations of a large number of subjects show a tight correlation between habitual diets, fecal microbiome signatures, and markers of metabolic health. Diets that score higher in healthfulness or diversity such as plant-based diets, have altered ratios of specific bacteria, including an increase in short-chain fatty acid producers, which in turn have been linked to improved metabolic markers and lowered cancer risk. Contrarily, numerous studies have implicated less healthy, lower-scoring diets such as the Western diet with reduced intestinal epithelial defenses and promotion of specific bacteria that affect carcinogenic pathways. In this review, we will describe how different dietary patterns affect microbial populations in the gut and illustrate the subsequent impact of bacterial products and metabolites on molecular pathways of cancer development, both locally in the gut and systemically in distant organs. C1 [Ibragimova, Shakhzada; Ramachandran, Revathy; Ali, Fahad R.; Lipovich, Leonard; Ho, Samuel B.] Mohammed Bin Rashid Univ Med & Hlth Sci, Coll Med, Dubai Healthcare City, Dubai, U Arab Emirates. [Ho, Samuel B.] Med City Hosp, Dept Med, Dubai Healthcare City, Dubai, U Arab Emirates. RP Ho, SMB (通讯作者)，Mohammed Bin Rashid Univ Med & Hlth Sci, Coll Med, Dubai Healthcare City, Dubai, U Arab Emirates.; Ho, SMB (通讯作者)，Med City Hosp, Dept Med, Dubai Healthcare City, Dubai, U Arab Emirates. 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Cell. Dev. Biol. PD NOV 12 PY 2021 VL 9 AR 725821 DI 10.3389/fcell.2021.725821 PG 21 WC Cell Biology; Developmental Biology WE Science Citation Index Expanded (SCI-EXPANDED) SC Cell Biology; Developmental Biology GA XH6UP UT WOS:000725567600001 PM 34869313 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Aleksandrova, K Koelman, L Rodrigues, CE AF Aleksandrova, Krasimira Koelman, Liselot Rodrigues, Caue Egea TI Dietary patterns and biomarkers of oxidative stress and inflammation: A systematic review of observational and intervention studies SO REDOX BIOLOGY LA English DT Review DE Dietary patterns; Oxidative stress; Inflammation; Biomarkers; Systematic review ID FATTY LIVER-DISEASE; MEDITERRANEAN DIET; METABOLIC SYNDROME; DNA-DAMAGE; CARDIOVASCULAR-DISEASE; PRIMARY PREVENTION; LIFE-STYLE; DASH DIET; ANTIOXIDANTS; CANCER AB Introduction: Oxidative stress and inflammation are known to play a critical role in ageing and chronic disease development and could therefore represent important targets for developing dietary strategies for disease prevention. We aimed to systematically review the results from observational studies and intervention trials published in the last 5 years on the associations between dietary patterns and biomarkers of oxidative stress and inflammation. Methods: A systematic search of the PubMed, MEDLINE and Web of Science (January 2015 to October 2020) was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Methodological quality of selected studies was evaluated based on the NUTRIGRADE and BIOCROSS assessment tools. Results: In total, 29 studies among which 16 observational studies and 13 intervention studies were found eligible for review. Overall, results indicated an inverse association between plant-based diets - the Mediterranean and Dietary Approaches to Stop Hypertension (DASH) diet - and oxidative stress and proinflammatory biomarkers. In observational studies, inverse associations were further revealed for the vegetarian diet, the USDA Healthy Eating Index (HEI) - based diet and the paleolithic diet, whereas a positive association was seen for western and fast food diets. Quality assessment suggested that majority of dietary intervention studies (n = 12) were of low to moderate quality. Conclusions: This study provides evidence that the plant-based dietary patterns are associated with lowered levels of oxidative stress and inflammation and may provide valid means for chronic disease prevention. Future largescale intervention trials using validated biomarkers are warranted to confirm these findings. C1 [Aleksandrova, Krasimira; Koelman, Liselot; Rodrigues, Caue Egea] German Inst Human Nutr Potsdam Rehbruecke DIfE, Dept Nutr & Gerontol, Nutr Immun & Metab Senior Scientist Grp, Nuthetal, Germany. [Aleksandrova, Krasimira] Leibniz Inst Prevent Res & Epidemiol, Dept Epidemiol Methods & Etiol Res, Bremen, Germany. [Aleksandrova, Krasimira] Univ Bremen, Fac Human & Hlth Sci, Bremen, Germany. [Rodrigues, Caue Egea] Free Univ Berlin, Inst Pharm, Berlin, Germany. C3 Leibniz Association; Deutsches Institut fur Ernahrungsforschung Potsdam-Rehbrucke (DIfE); Leibniz Association; Leibniz Institute for Prevention Research & Epidemiology (BIPS); University of Bremen; Free University of Berlin RP Aleksandrova, K (通讯作者)，Leibniz Inst Prevent Res & Epidemiol, Dept Epidemiol Methods & Etiol Res, Bremen, Germany. 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PD JUN PY 2021 VL 42 AR 101869 DI 10.1016/j.redox.2021.101869 EA APR 2021 PG 16 WC Biochemistry & Molecular Biology WE Science Citation Index Expanded (SCI-EXPANDED) SC Biochemistry & Molecular Biology GA RS5WQ UT WOS:000643849500010 PM 33541846 OA Green Submitted, gold HC Y HP N DA 2026-02-02 ER PT J AU Ramos-Júdez, S Estévez, A González-López, WA Duncan, N AF Ramos-Judez, Sandra Estevez, Alicia Gonzalez-Lopez, Wendy Angela Duncan, Neil TI Lipid and fatty acid composition of muscle, liver, ovary, and peritoneal fat in wild flathead grey mullet (Mugil cephalus) according to ovarian development SO THERIOGENOLOGY LA English DT Article DE Mugil cephalus; Western Mediterranean; Fatty acids; Liver; Muscle; Ovary ID REPRODUCTIVE-PERFORMANCE; BROODSTOCK NUTRITION; CULTURED BROODSTOCK; LARVAL QUALITY; STRIPED MULLET; EGG; PROXIMATE; FISH; PROFILES; AURATA AB Wild adult females of a low trophic omnivore teleost species, the flathead grey mullet (Mugil cephalus), caught in the western Mediterranean were sampled. The lipid and fatty acid composition of ovaries, liver, muscle, and peritoneal fat were analysed at previtellogenesis, early-vitellogenesis-first observed at mid-summer (early August)-, late-vitellogenesis, and the post-spawning period-from mid-September to mid-October-. During ovarian development, the lipid content of muscle was low and constant (3.85%-4.92%), indicating that the muscle was not used to store lipids for gonadal growth. Although constant, lipid content in the liver was higher (18.46%-22.62%) than in the muscle, and HSI% increased during gonad development, suggesting a dynamism in the mobilization of the hepatic lipids. Total lipids in the gonads significantly increased with maturation (from 4.90% to 34.59%) in parallel with the GSI (from 0.8% to 15.5%) to decrease after spawning. Peritoneal fat was probably transitional fat that could be rapidly metabolized or transferred to other tissues but no specific function could be assigned because its presence in previtellogenic and early-vitellogenic females varied greatly. One of the main sources of lipids accumulated in the ovary was most likely diet. The total percentage of SMUFA, mainly 17:1-previously not identified in high quantities in teleost vitellogenic ovaries and likely of bacterial ori- gin-and 16:1, strongly increased in the ovaries with maturation. The 16:1 might be an important source of lipids for embryo development. High percentages of DHA, EPA, and ARA were found in the ovary during previtellogenesis available to be used during gonadal maturation. Understanding lipid and fatty acid changes in broodstock tissues can increase our knowledge of the nutritional requirements of the fish used in aquaculture breeding programs.(c) 2023 Elsevier Inc. All rights reserved. C1 [Ramos-Judez, Sandra; Estevez, Alicia; Gonzalez-Lopez, Wendy Angela; Duncan, Neil] IRTA, Sant Carles Rapita Ctra,Poble Nou km 5-5, Tarragona 43540, Spain. [Ramos-Judez, Sandra] S2AQUAcoLAB, Ave Parque Nat Ria Formosa S-N, P-8700194 Olhao, Portugal. C3 IRTA RP Ramos-Júdez, S; Duncan, N (通讯作者)，IRTA, Sant Carles Rapita Ctra,Poble Nou km 5-5, Tarragona 43540, Spain. EM sandra.ramos@s2aquacolab.pt; neil.duncan@irta.cat RI Estévez, Alicia/K-7863-2014; Duncan, Neil/B-8906-2013; Ramos Júdez, Sana/HJP-4741-2023 OI Estévez, Alicia/0000-0002-7776-0521; Ramos Júdez, Sana/0000-0003-4242-5894 FU Spanish Government MINECO project [RTI2018-094710-R-I00]; AGAUR, Government of Catalonia - European Social Fund; National Board of Science and Technology (CONACYT, Mexico) FX This study has been supported with funding from Spanish Government MINECO project [grant RTI2018-094710-R-I00] coordinated by ND. The participation of SR and WG was funded, respectively, by a PhD grant from AGAUR, Government of Catalonia) co-financed by the European Social Fund and a PhD grant from the National Board of Science and Technology (CONACYT, Mexico). The authors would like to give special thanks to Marta Sastre and Maria Curto from IRTA, and Juan Carlos Navarro from Instituto de Acuicultura Torre de la Sal (Spain) for the help in fatty acid identification. Thanks also to Ana Yoshihara Estevez and Cristian Martinez Rodriguez for help in sampling and histological preparation. CR Abalos M, 2011, DECONTAMINATION TREN, DOI [10.1016/j.chemosphere.2010.10.008, DOI 10.1016/J.CHEMOSPHERE.2010.10.008] Aguirre ALI, 2004, B MAR SCI, V75, P37 Ameur Btissam, 2003, Bulletin de l'Institut Scientifique Section Sciences de la Vie - Rabat, V25, P77 ARGYROPOULOU V, 1992, COMP BIOCHEM PHYS A, V101, P129, DOI 10.1016/0300-9629(92)90640-C Assem S. 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Ernst, Thomas Buchthal, Steven D. Shepherd, John A. Wilkens, Lynne R. Le Marchand, Loic Boushey, Carol J. TI Diet Quality in Midadulthood Predicts Visceral Adiposity and Liver Fatness in Older Ages: The Multiethnic Cohort Study SO OBESITY LA English DT Article ID CORONARY-HEART-DISEASE; MEDITERRANEAN DIET; LOS-ANGELES; LIFE-STYLE; TISSUE; PATTERNS; RISK; WOMEN; ADHERENCE; ADULTS AB Objective: The relationship of diet quality assessed by established indices (HEI-2010, AHEI-2010, aMED, DASH) with adiposity measures was examined, especially visceral adipose tissue (VAT) and nonalcoholic fatty liver (NAFL). Methods: Close to 2,000 participants of the Multiethnic Cohort completed validated food frequency questionnaires at cohort entry (1993-1996) and clinic visit (2013-2016) when they underwent whole-body dual-energy x-ray absorptiometry and abdominal magnetic resonance imaging scans. Linear regression was used to estimate mean values of adiposity measures by dietary index tertiles at baseline and standardized regression coefficients (beta(s)) after adjusting for total adiposity and other covariates. Logistic regression of VAT and NAFL on dietary indices was also performed. Results: Higher dietary quality scores at cohort entry were inversely related to all adiposity measures, with the strongest associations for percent liver fat (beta(s) = 0.14 to 20.08), followed by VAT (beta(s) = 0.11 to -0.05), BMI (beta(s) = -0.11 to -0.06), and total body fat (beta(s) = -0.09 to -0.05). Odds ratios adjusted for total adiposity ranged between 0.57 and 0.77 for NAFL and between 0.41 and 0.65 for high VAT when comparing the highest versus lowest tertiles of diet quality. Conclusions: These longitudinal findings indicate that maintaining a high-quality diet during mid-to-late adulthood may prevent adverse metabolic consequences related to VAT and NAFL. C1 [Maskarinec, Gertraud; Lim, Unhee; Jacobs, Simone; Ernst, Thomas; Wilkens, Lynne R.; Le Marchand, Loic; Boushey, Carol J.] Univ Hawaii, Canc Ctr, Honolulu, HI 96822 USA. [Monroe, Kristine R.] Univ Southern Calif, Dept Prevent Med, Los Angeles, CA USA. [Buchthal, Steven D.] Queens Med Ctr, Honolulu, HI USA. [Shepherd, John A.] Univ Calif San Francisco, Dept Radiol & Biomed Imaging, San Francisco, CA 94143 USA. C3 University of Hawaii System; Cancer Research Center of Hawaii; University of Southern California; The Queen's Medical Center; University of California System; University of California San Francisco RP Maskarinec, G (通讯作者)，Univ Hawaii, Canc Ctr, Honolulu, HI 96822 USA. EM gertraud@cc.hawaii.edu RI Lim, Unhee/AEA-8591-2022; Shepherd, John/S-3146-2018 OI Lim, Unhee/0000-0001-6221-7190; Shepherd, John/0000-0003-2280-2541; Jaco, Simone/0009-0008-3883-5202 FU US National Institutes of Health [P01CA169530, U01CA164973, P30CA071789, UL1TR000130]; National Cancer Institute [U01CA164973, P30CA071789] Funding Source: NIH RePORTER; National Center for Advancing Translational Sciences [UL1TR001855] Funding Source: NIH RePORTER; National Institute of Diabetes and Digestive and Kidney Diseases [P30DK098722] Funding Source: NIH RePORTER FX This work was supported by the US National Institutes of Health (P01CA169530, U01CA164973, P30CA071789, UL1TR000130). 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Among other factors, the HDL lipidome is affected by diet. We hypothesized that diet supplementation with ?3 (docosahexaenoic acid: DHA and eicosapentaenoic acid: EPA) and phytosterols (PhyS) would improve the HDL lipid profile. Overweight subjects (n = 20) were enrolled in a two-arm longitudinal crossover study. Milk (250 mL/day), supplemented with either ?3 (EPA + DHA, 375 mg) or PhyS (1.6 g), was administered to the volunteers over two consecutive 28-day intervention periods, followed by HDL lipidomic analysis. The comprehensive lipid pattern revealed that the HDL lipidome is diet-dependent. ?3-milk supplementation produced more changes than PhyS, mainly in cholesteryl esters (CEs). After ?3-milk intake, levels of DHA and EPA within phosphatylcholines, triglycerides and CE lipids in HDLs increased (p < 0.05). The correlation between lipid species showed that lipid changes occur in a coordinated manner. Finally, our analysis revealed that the HDL lipidome is also sex-dependent. The HDL lipidome is affected by diet and sex, and the 4 weeks of ?3 supplementation induced HDL enrichment with EPA and DHA. C1 [Padro, Teresa; Lopez-Yerena, Anallely; Vilahur, Gemma; Badimon, Lina] Inst Invest Biomed St Pau IIB St PAU, Cardiovasc Program ICCC, Barcelona 08041, Spain. [Padro, Teresa; Vilahur, Gemma; Badimon, Lina] Inst Salud Carlos III, Ctr Invest Biomed Red Cardiovasc CIBERCV, Madrid 28029, Spain. [Perez, Antonio] Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Serv Endocrinol & Nutr, IIB St Pau, Barcelona 08041, Spain. [Perez, Antonio] CIBER Diabet & Enfermedades Metab Asociadas CIBERD, Barcelona 08041, Spain. [Badimon, Lina] Univ Autonoma Barcelona UAB, Barcelona 08193, Spain. C3 Institut de Recerca Sant Pau; Instituto de Salud Carlos III; CIBER - Centro de Investigacion Biomedica en Red; CIBERCV; Hospital of Santa Creu i Sant Pau; Institut de Recerca Sant Pau; Autonomous University of Barcelona; Hospital Universitari Vall d'Hebron; Autonomous University of Barcelona RP Padro, T (通讯作者)，Inst Invest Biomed St Pau IIB St PAU, Cardiovasc Program ICCC, Barcelona 08041, Spain.; Padro, T (通讯作者)，Inst Salud Carlos III, Ctr Invest Biomed Red Cardiovasc CIBERCV, Madrid 28029, Spain. EM tpadro@santpau.cat; naye.yerena@gmail.com; aperez@santpau.ca; gvilahur@santpau.cat; lbadimon@santpau.cat RI López Yerena, Anallely/GRO-2167-2022; Badimon, Lina/S-2950-2019 OI López Yerena, Anallely/0000-0002-4333-9798; Badimon, Lina/0000-0002-9162-2459; Pérez, Antonio/0000-0001-5528-1143; Pao, Teresa/0000-0003-1921-954X FU CDTI Spanish Ministry of Competitiveness and Economy (MINECO) [CEN-20101016]; MICINN-AEI [PID2019-107160RB-I00, PID2021-128891OB-I00]; Instituto de Salud Carlos III (ISCIII) [FISPI19/01687]; FEDER "Una Manera de Hacer Europa" FX & nbsp;This work was supported by grants from the CDTI Spanish Ministry of Competitiveness and Economy (MINECO) (CEN-20101016 (HENUFOOD) to L.B.; MICINN-AEI, project ref. AEI/10.13039/501100011033-[PID2019-107160RB-I00] to L.B. and PID2021-128891OB-I00 to G.V.; from the Instituto de Salud Carlos III (ISCIII) FISPI19/01687 to T.P.; and CIBERCV to L.B., cofounded by FEDER "Una Manera de Hacer Europa". We express our appreciation to Fundacion Jesus Serra-Fundacion de Investigacion Cardiovascular (Barcelona, Spain) for their ongoing assistance. 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Isabel Vargas-Candela, Antonio Vilches-Perez, Alberto Benitez-Porres, Javier Romance-Garcia, Angel Ramon Ruiz-Moreno, Alejandro Gomez-Huelgas, Ricardo Bernal-Lopez, M. Rosa TI Epigenetic approach in obesity: DNA methylation in a prepubertal population which underwent a lifestyle modification SO CLINICAL EPIGENETICS LA English DT Article DE Prepubertal population; Metabolically healthy obesity; Methylation; Lipid profile; Inflammatory profile; Lifestyle modification ID WEIGHT-LOSS; MEDITERRANEAN DIET; ADIPOSE-TISSUE; OVERWEIGHT; DEFINITION; METABOLISM; NUTRITION; GENETICS; PROMOTER; INSULIN AB Background Metabolically healthy obesity (MHO) is a considerably controversial concept as it is considered a transitory condition towards the development of different pathologies (type 2 diabetes, insulin resistance, or cardiovascular disease). MHO is closely related to lifestyle and environmental factors. Epigenetics has become an essential biological tool to analyze the link between obesity and metabolic status. The aim of this study was to determine whether MHO status is conditioned by the DNA methylation (DNAm) of several genes related to lipid metabolism (lipoprotein lipase, retinoid X receptor alpha, liver X receptor, stearoyl-CoA desaturase, sterol regulatory element binding factor 1), and inflammation (LEP) in peripheral blood mononuclear cells (PBMCs) from 131 prepubertal subjects with MHO phenotype after lifestyle modifications with personalized Mediterranean diet (MedDiet) combined with a physical activity (PA) program. Results The DNAm of all studied genes were significantly modified in the population after 12 months of lifestyle modifications (MedDiet and PA). In addition, associations were found between the DNAm studies and BMI, homeostatic model assessment of insulin resistance, monounsaturated fatty acid and polyunsaturated fatty acid, moderate-vigorous PA, fat mass, and adherence to MedDiet. Conclusions It was found that DNAm of genes related to lipid metabolism and inflammation are also present in childhood and that this methylation profile can be modified by interventions based on MedDiet and PA. C1 [Gallardo-Escribano, Cristina] Reg Univ Hosp Malaga, Clin Anal Dept, Malaga, Spain. [Buonaiuto, Veronica; Ruiz-Moreno, M. Isabel; Vargas-Candela, Antonio; Ruiz-Moreno, Alejandro; Gomez-Huelgas, Ricardo; Bernal-Lopez, M. Rosa] Reg Univ Hosp Malaga, Inst Invest Biomed Malaga IBIMA, Internal Med Dept, Malaga, Spain. [Vilches-Perez, Alberto] Univ Hosp Virgen Victoria, Inst Invest Biomed Malaga IBIMA, Endocrinol & Nutr Dept, Malaga, Spain. [Benitez-Porres, Javier] Univ Malaga, Phys Educ & Sports Fac Med, Dept Human Physiol, Malaga, Spain. [Romance-Garcia, Angel Ramon] Univ Malaga, Fac Educ Sci, Dept Didact Language Arts & Sport, Biodynam & Body Composit Lab, Malaga, Spain. [Gomez-Huelgas, Ricardo; Bernal-Lopez, M. Rosa] Carlos III Hlth Inst, CIBER Patofisiol Obesidad Nutr, Madrid, Spain. C3 IBIMA Plataforma BIONAND, Instituto de Investigacion Biomedica de Malaga; Universidad de Malaga; Universidad de Malaga; IBIMA Plataforma BIONAND, Instituto de Investigacion Biomedica de Malaga; Universidad de Malaga; Universidad de Malaga RP Gomez-Huelgas, R; Bernal-Lopez, MR (通讯作者)，Reg Univ Hosp Malaga, Inst Invest Biomed Malaga IBIMA, Internal Med Dept, Malaga, Spain. EM ricardogomezhuelgas@hotmail.com; robelopajiju@yahoo.es RI Benítez Porres, Javier/R-5211-2019; Gomez Huelgas, Ricardo/ABF-5100-2021; Bernal-Lopez, M/N-3564-2016 OI Benítez Porres, Javier/0000-0001-7546-7965; Gomez Huelgas, Ricardo/0000-0002-9909-3555; FU Instituto de Salud Carlos III; Fondo Europeo de Desarrollo Regional-FEDER ("Centros de Investigacion En Red" (CIBER)) [CB06/03/0018]; Miguel Servet Type I" program from the ISCIII-Madrid (Spain) [CP15/00028]; Fondo Europeo de Desarrollo Regional-FEDER FX This work was supported by grants from the Instituto de Salud Carlos III, cofinanced by the Fondo Europeo de Desarrollo Regional-FEDER ("Centros de Investigacion En Red" (CIBER, CB06/03/0018)). M Rosa Bernal-Lopez was supported by "Miguel Servet Type I" program (CP15/00028) from the ISCIII-Madrid (Spain), cofinanced by the Fondo Europeo de Desarrollo Regional-FEDER. 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Epigenetics PD SEP 23 PY 2020 VL 12 IS 1 AR 144 DI 10.1186/s13148-020-00935-0 PG 14 WC Oncology; Genetics & Heredity WE Science Citation Index Expanded (SCI-EXPANDED) SC Oncology; Genetics & Heredity GA NV8ZT UT WOS:000574602900001 PM 32967728 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Toprak-Semiz, A Yavuz-Bedir, E Yüzüak, H Usta, M Sengül, D AF Toprak-Semiz, Ayca Yavuz-Bedir, Efsane Yuzuak, Hakan Usta, Murat Sengul, Demet TI High fructose corn syrup ınduced liver and heart damage are not reversed with hazelnut consumption: In vivo study SO PLOS ONE LA English DT Article ID MEDITERRANEAN DIET; DYSFUNCTION; OXIDATION AB Hazelnut, antioxidant, anti-inflammatory effects, has an important role in a healthy diet. High fructose corn syrup (HFCS), used as a sweetener in ready-made food, beverages; causes hyperlipidemia, fatty liver, cardiovascular system damages; oxidative stress, inflammation play role in these damages. Based on these data, we aimed to examine liver and heart damage caused by HFCS in rats and to investigate possible role of hazelnut enriched food in preventing/improving these damages. During this process, weight change, food, liquid consumption were recorded. Biochemical parameters were measured with standard enzymatic techniques. Inflammatory cytokines were determined by ELISA. Liver and heart tissues were evaluated histopathologically, changes were scored, graded. HFCS decreased food, increased liquid consumption. Feeding with hazelnut reduced fluid consumption. HFCS increased weight gain, hazelnut did not reverse it. LDH, CK values increased in HFCS group due to heart damage. While damage occurred in livers of HFCS group due to increased levels of TNF-alpha and IL-1 ss, feeding with hazelnut did not change it. In heart, inflammatory cytokines were similar between groups. In histopathological analysis, inflammation was observed both in livers, hearts of HFCS group. In hazelnut group, a significant decrease in damage was observed compared to HFCS, HFCS+H groups. According to our results, hazelnut supplementation reduced liquid intake and showed limited cardiac protection, but did not reverse HFCS-induced hepatic or cardiac injury. C1 [Toprak-Semiz, Ayca] Recep Tayyip Erdogan Univ, Fac Med, Dept Med Pharmacol, Rize, Turkiye. [Toprak-Semiz, Ayca; Yavuz-Bedir, Efsane] Giresun Univ, Vocat Sch Hlth Serv, Dept Med Serv & Tech, Giresun, Turkiye. [Yuzuak, Hakan] Giresun Univ, Fac Med, Dept Physiol, Giresun, Turkiye. [Usta, Murat] Giresun Univ, Fac Med, Dept Med Biochem, Giresun, Turkiye. [Sengul, Demet] Giresun Univ, Fac Med, Dept Pathol, Giresun, Turkiye. C3 Recep Tayyip Erdogan University; Giresun University; Giresun University; Giresun University; Giresun University RP Toprak-Semiz, A (通讯作者)，Recep Tayyip Erdogan Univ, Fac Med, Dept Med Pharmacol, Rize, Turkiye.; Toprak-Semiz, A (通讯作者)，Giresun Univ, Vocat Sch Hlth Serv, Dept Med Serv & Tech, Giresun, Turkiye. EM ayca.semiz@erdogan.edu.tr RI Toprak-Semiz, Ayça/AAH-4054-2019 OI SEMIZ, AYÇA/0000-0002-0567-6769; Yavuz Bedir, Efsane/0000-0001-8212-9622 FU Giresun niversitesi [SAGbreve; BAP A-24022250] FX This study was supported by Scientific Research Projects Coordination Unit of Giresun University, Project Number: SA & Gbreve;-BAP-A-240222-50. 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Georgopoulou, Katerina Agrogiannis, George Karatzas, Theodore Iliopoulos, Dimitrios Papalois, Apostolos Chatziioannou, Achilles Magiatis, Prokopios Halabalaki, Maria Tsantila, Nektaria Skaltsounis, Leandros A. Patsouris, Efstratios Dontas, Ismene A. TI Differential effect of Pistacia vera extracts on experimental atherosclerosis in the rabbit animal model: an experimental study SO LIPIDS IN HEALTH AND DISEASE LA English DT Article ID OLIVE OIL; HYPERCHOLESTEROLEMIC ATHEROSCLEROSIS; ANTIOXIDANT ACTIVITY; LIPID PEROXIDES; VIRGIN-OLIVE; GREEN TEA; CHOLESTEROL; DISEASE; LENTISCUS; LIVER AB Background: Lipid-enriched diets and oxidative stress are risk factors for the development of atherosclerosis. The effects of the methanolic (ME) and cyclohexane (CHE) extracts of the Pistacia vera nut, often included in the Mediterranean diet, were studied in the rabbit model of atherosclerosis. Methods and results: Twenty-four New Zealand White rabbits received atherogenic diet (Control Group), supplemented with ME (Group ME) or CHE (Group CHE) for 3 months. Previously, a GC-MS and a UHPLC LC-DAD-ESI(-)-HRMS/MS method were developed to investigate the extracts' chemical profiles. Blood samples at baseline and monthly determined lipid profile, lipid peroxidation and liver function. The aorta, myocardium and liver were examined histologically at 3 months. Groups ME and CHE had significantly higher HDL- and non-significantly lower LDL-cholesterol median % changes from baseline than the Control Group. Triacylglycerol was significantly higher in Group CHE vs. Control. MDA values were significantly lower in Group ME vs. Control and CHE. ALT and AST were significantly higher in Group CHE vs. Control. gamma-GT was lower in Group ME vs. Control. Aortic intimal thickness was significantly less in Groups ME and CHE vs. Control; Group ME atherosclerotic lesions were significantly less extensive vs. Groups Control and CHE. Only Group CHE had significant liver fatty infiltration. Conclusions: During short-term administration concomitantly with atherogenic diet, both P. vera extracts were beneficial on HDL-, LDL-cholesterol and aortic intimal thickness. The ME additionally presented an antioxidant effect and significant decrease of aortic surface lesions. These results indicate that P. vera dietary inclusion, in particular its ME, is potentially beneficial in atherosclerosis management. C1 [Marinou, Katerina A.; Karatzas, Theodore; Iliopoulos, Dimitrios; Dontas, Ismene A.] Univ Athens, Lab Expt Surg & Surg Res Christeas Hall, Sch Med, GR-10679 Athens, Greece. [Marinou, Katerina A.] Ctr Athens Vet Inst, Minist Rural Dev & Food, Attiki, Greece. [Georgopoulou, Katerina; Magiatis, Prokopios; Halabalaki, Maria; Skaltsounis, Leandros A.] Univ Athens, Div Pharmacognosy & Nat Prod Chem, Dept Pharm, GR-10679 Athens, Greece. [Agrogiannis, George; Patsouris, Efstratios] Univ Athens, Dept Pathol 1, Sch Med, GR-10679 Athens, Greece. [Karatzas, Theodore] Univ Athens, Dept Propedeut Surg 2, Laiko Hosp, Sch Med, GR-10679 Athens, Greece. [Papalois, Apostolos] Expt Res Ctr ELPEN Pharma, Pikermi, Greece. [Chatziioannou, Achilles] Univ Athens, Dept Radiol 1, Sch Med, Aretaieion Univ Hosp, GR-10679 Athens, Greece. [Tsantila, Nektaria] Univ Athens, Lab Biochem, Dept Chem, GR-10679 Athens, Greece. [Dontas, Ismene A.] Univ Athens, Lab Res Musculoskeletal Syst, Dept Chem, GR-10679 Athens, Greece. C3 National & Kapodistrian University of Athens; National & Kapodistrian University of Athens; National & Kapodistrian University of Athens; National & Kapodistrian University of Athens; Laiko General Hospital; National & Kapodistrian University of Athens; National & Kapodistrian University of Athens; National & Kapodistrian University of Athens RP Dontas, IA (通讯作者)，Univ Athens, Lab Expt Surg & Surg Res Christeas Hall, Sch Med, GR-10679 Athens, Greece. EM idontas@med.uoa.gr RI skaltsounis, alexios/AAE-9617-2019; Magiatis, Prokopios/A-2008-2008; Dontas, Ismene/A-3584-2008; iliopoulos, dimitrios/AAE-9106-2019; Halabalaki, Maria/AAD-2127-2020 OI Magiatis, Prokopios/0000-0002-0399-5344; Dontas, Ismene/0000-0002-2440-0119; iliopoulos, dimitrios/0000-0003-2780-2372; Halabalaki, Maria/0000-0001-5620-0165 FU Greek Ministry of Rural Development and Food; National and Kapodistrian University of Athens [70/4/2591] FX Dr. K. Marinou is grateful to the Greek Ministry of Rural Development and Food for its support and educational leave of absence, and to Professor D.N. Perrea for valuable counselling and support in the study. Dr. Dontas acknowledges the Special Account for Research Grants (no. 70/4/2591) of the National and Kapodistrian University of Athens for its financial support. The authors acknowledge Biostatistician Dr. A. Galanos for the expert statistical analysis of the study and acknowledge the expert assistance of K. Perrea, K. Papadaki, E. Dousi, G. Pantelis, P. Rapos and Z. Mertiri during the experiments. 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Solanas, Montserrat Moral, Raquel Escrich, Raquel Vela, Elena Costa, Irmgard Escrich, Eduard TI Dietary extra-virgin olive oil and corn oil differentially modulate the mRNA expression of xenobiotic-metabolizing enzymes in the liver and in the mammary gland in a rat chemically induced breast cancer model SO EUROPEAN JOURNAL OF CANCER PREVENTION LA English DT Article DE breast cancer; Mediterranean diet; n-6 polyunsaturated fatty acids; extra-virgin olive oil; xenobiotic metabolism ID MOLECULAR-MECHANISMS; LIPID INFLUENCE; FAT; CHEMOPREVENTION; ACTIVATION; INDUCTION; CARCINOMA; CYP1B1; TUMORS; GENES AB High extra-virgin olive oil (EVOO) and corn oil diets differentially modulate experimental mammary carcinogenesis. We have investigated their influence on the initiation stage through the modulation of the expression of xenobiotic-metabolizing enzymes (XMEs) in the liver and the mammary gland. Female Sprague-Dawley rats were fed a low-fat (LF), high corn oil (HCO), or high EVOO (HOO) diet from weaning and gavaged with 7,12-dimethylbenz(a) anthracene (DMBA). The HCO diet increased the mRNA levels of the phase I enzymes CYP1A1, CYP1A2 and, to a lesser extent, CYP1B1, in the liver. The Aryl hydrocarbon receptor (AhR) seemed to be involved in this upregulated CYP1 expression. However, a slight trend toward an increase in the mRNA levels of the phase II enzymes GSTP1 and NQO1 was observed with the HOO diet. At least in the case of GSTP1, this effect was linked to an increased Nrf2 transactivation activity. This different regulation of the XMEs expression led, in the case of the HCO diet, to a balance between the production of active carcinogenic compounds and their inactivation tilted toward phase I, which would stimulate DMBA-induced cancer initiation, whereas the HOO diet was associated with a slower phase I metabolism accompanied by a faster phase II detoxification, thus reducing the output of the active compounds to the target tissues. In the mammary gland, the differential effects of diets may be conditioned by the state of cell differentiation, sexual maturity, and hormone metabolism. Copyright (C) 2015 Wolters Kluwer Health, Inc. All rights reserved. C1 [Manzanares, Miguel A.; Solanas, Montserrat; Moral, Raquel; Escrich, Raquel; Vela, Elena; Costa, Irmgard; Escrich, Eduard] Univ Autonoma Barcelona, Sch Med, Dept Cell Biol Physiol & Immunol, Med Physiol Unit, E-08193 Barcelona, Spain. [Costa, Irmgard] Corp Sanitaria Parc Tauli, Dept Pathol, Sabadell, Spain. C3 Autonomous University of Barcelona; Autonomous University of Barcelona; Parc Tauli Hospital Universitari RP Escrich, E (通讯作者)，Univ Autonoma Barcelona, Sch Med, Dept Cell Biol Physiol & Immunol, Med Physiol Unit, E-08193 Barcelona, Spain. EM eduard.escrich@uab.es RI Moral, Raquel/H-2122-2015; Vela, Elena/MZQ-5699-2025; Garcia, Montserrat/O-4684-2016 OI Moral, Raquel/0000-0002-2738-6121; SOLANAS GARCIA, MONTSERRAT/0000-0003-2949-1344; Manzanares, Miguel Ángel/0000-0002-1458-230X; FU 'Plan Nacional de I + D + I' [AGL2006-07691, AGL2011-24778]; 'Fundacion Patrimonio Comunal Olivarero' [FPCO2008-165.396]; 'Agencia para el Aceite de Oliva, Ministerio de Medio Ambiente y de Medio Rural y Marino' [AAO2008-165.471]; 'Organizacion Interprofesional del Aceite de Oliva Espanola' [OIP2009-165.646] FX This work was supported by grants from 'Plan Nacional de I + D + I 2004-2007' (AGL2006-07691); 'Plan Nacional de I + D + I 2007-2011' (AGL2011-24778); 'Fundacion Patrimonio Comunal Olivarero 2008-2012' (FPCO2008-165.396); 'Agencia para el Aceite de Oliva, Ministerio de Medio Ambiente y de Medio Rural y Marino 2008-2012' (AAO2008-165.471); and 'Organizacion Interprofesional del Aceite de Oliva Espanola 2009-2013' (OIP2009-165.646). The sponsors had no role in the study design, data collection and analysis, interpretation of results, the preparation of the manuscript, the decision to submit the manuscript for publication, or the writing of the manuscript. 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J. Cancer Prev. PD MAY PY 2015 VL 24 IS 3 BP 215 EP 222 DI 10.1097/CEJ.0000000000000032 PG 8 WC Oncology WE Science Citation Index Expanded (SCI-EXPANDED) SC Oncology GA CE5YG UT WOS:000351911700008 PM 24722539 DA 2026-02-02 ER PT J AU Esselun, C Dilberger, B Silaidos, CV Koch, E Schebb, NH Eckert, GP AF Esselun, Carsten Dilberger, Benjamin Silaidos, Carmina, V Koch, Elisabeth Schebb, Nils Helge Eckert, Gunter P. TI A Walnut Diet in Combination with Enriched Environment Improves Cognitive Function and Affects Lipid Metabolites in Brain and Liver of Aged NMRI Mice SO NEUROMOLECULAR MEDICINE LA English DT Article DE Mitochondrial function; Brain; Liver; Oxylipins; Cognition; Behaviour; NMRI; Ageing; Neurodegeneration ID ALPHA-LINOLENIC ACID; POLYUNSATURATED FATTY-ACIDS; MITOCHONDRIAL DYSFUNCTION; DOCOSAHEXAENOIC ACID; MEDITERRANEAN DIET; EICOSAPENTAENOIC ACID; NERVOUS-SYSTEM; SPATIAL MEMORY; NITRIC-OXIDE; LIFE-SPAN AB This in vivo study aimed to test if a diet enriched with 6% walnuts alone or in combination with physical activity supports healthy ageing by changing the oxylipin profile in brain and liver, improving motor function, cognition, and cerebral mitochondrial function. Female NMRI mice were fed a 6% walnut diet starting at an age of 12 months for 24 weeks. One group was additionally maintained in an enriched environment, one group without intervention served as control. After three months, one additional control group of young mice (3 weeks old) was introduced. Motor and cognitive functions were measured using Open Field, Y-Maze, Rotarod and Passive Avoidance tests. Lipid metabolite profiles were determined using RP-LC-ESI(-)-MS/MS in brain and liver tissues of mice. Cerebral mitochondrial function was characterized by the determination of ATP levels, mitochondrial membrane potential and mitochondrial respiration. Expression of genes involved with mito- and neurogenesis, inflammation, and synaptic plasticity were determined using qRT-PCR. A 6% walnut-enriched diet alone improved spatial memory in a Y-Maze alternation test (p < 0.05) in mice. Additional physical enrichment enhanced the significance, although the overall benefit was virtually identical. Instead, physical enrichment improved motor performance in a Rotarod experiment (p* < 0.05) which was unaffected by walnuts alone. Bioactive oxylipins like hydroxy-polyunsaturated fatty acids (OH-PUFA) derived from linoleic acid (LA) were significantly increased in brain (p** < 0.01) and liver (p*** < 0.0001) compared to control mice, while OH-PUFA of alpha-linolenic acid (ALA) could only be detected in the brains of mice fed with walnuts. In the brain, walnuts combined with physical activity reduced arachidonic acid (ARA)-based oxylipin levels (p < 0.05). Effects of walnut lipids were not linked to mitochondrial function, as ATP production, mitochondrial membrane potential and mitochondrial respiration were unaffected. Furthermore, common markers for synaptic plasticity and neuronal growth, key genes in the regulation of cytoprotective response to oxidative stress and neuronal growth were unaffected. Taken together, walnuts change the oxylipin profile in liver and brain, which could have beneficial effects for healthy ageing, an effect that can be further enhanced with an active lifestyle. Further studies may focus on specific nutrient lipids that potentially provide preventive effects in the brain. C1 [Esselun, Carsten; Dilberger, Benjamin; Silaidos, Carmina, V; Eckert, Gunter P.] Justus Liebig Univ, Biomed Res Ctr Seltersberg BFS, Inst Nutr Sci, Lab Nutr Prevent & Therapy, Schubertstr 81, D-35392 Giessen, Germany. [Koch, Elisabeth; Schebb, Nils Helge] Univ Wuppertal, Fac Math & Nat Sci, Chair Food Chem, Gaussstr 20, D-42119 Wuppertal, Germany. C3 Justus Liebig University Giessen; University of Wuppertal RP Eckert, GP (通讯作者)，Justus Liebig Univ, Biomed Res Ctr Seltersberg BFS, Inst Nutr Sci, Lab Nutr Prevent & Therapy, Schubertstr 81, D-35392 Giessen, Germany. EM eckert@uni-giessen.de OI Esselun, Carsten/0000-0003-1193-8347; Schebb, Nils Helge/0000-0003-1299-6629; Eckert, Gunter Peter/0000-0002-8002-9983 FU California Walnut Commission FX Open Access funding enabled and organized by Projekt DEAL. This research was funded by a grant from the California Walnut Commission. 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Med. PD MAR PY 2021 VL 23 IS 1 SI SI BP 140 EP 160 DI 10.1007/s12017-020-08639-7 EA DEC 2020 PG 21 WC Neurosciences WE Science Citation Index Expanded (SCI-EXPANDED) SC Neurosciences & Neurology GA QR3ZQ UT WOS:000602292900001 PM 33367957 OA Green Submitted, hybrid DA 2026-02-02 ER PT J AU Capra, ME Monopoli, D Decarolis, NM Giudice, A Stanyevic, B Esposito, S Biasucci, G AF Capra, Maria Elena Monopoli, Delia Decarolis, Nicola Mattia Giudice, Antonella Stanyevic, Brigida Esposito, Susanna Biasucci, Giacomo TI Dietary Models and Cardiovascular Risk Prevention in Pediatric Patients SO NUTRIENTS LA English DT Review DE cardiovascular risk; dietary patterns; heart healthy diet; pediatrics; prevention ID LOW-CARBOHYDRATE DIET; FATTY LIVER-DISEASE; FACTOR INTERVENTION PROJECT; CLASSIC KETOGENIC DIET; CORONARY-HEART-DISEASE; INFANCY-ONSET DIETARY; C-REACTIVE PROTEIN; LIFE-STYLE FACTORS; BALTIC SEA DIET; BLOOD-PRESSURE AB Nutritional intervention is worldwide recognized as a first step treatment for subjects with increased cardiovascular risk and it is of utmost importance especially for children and adolescents. Currently scientific evidence supports the role of dietary patterns instead of simple single nutrients or foods in cardiovascular risk prevention. Indeed, the American Heart Association dietary guidelines have expanded beyond nutrients to dietary pattern, that comprise not only single food items but also behavioral or cultural habits of specific populations. The aim of our narrative review is to analyze the most frequently adopted dietary patterns in children and adolescents and to evaluate their effect on cardiovascular risk factors and in cardiovascular risk prevention. Literature review showed that children cannot be considered as little adults: nutritional intervention must always grant adequate growth and neurodevelopment before reaching the proposed goals, therefore dietary patterns considered heart-healthy for adult subjects might not be suitable for pediatric patients. Mediterranean diet, DASH diet, Nordic diet and some plant-based diets seem to be the most promising dietary patterns in terms of cardiovascular health in the developmental age, even if further studies are needed to better standardize and analyze their effect on growing up individuals. C1 [Capra, Maria Elena; Biasucci, Giacomo] Guglielmo da Saliceto Hosp, Pediat & Neonatol Unit, I-29121 Piacenza, Italy. [Capra, Maria Elena; Biasucci, Giacomo] Soc Italiana Nutr Pediat, I-20126 Milan, Italy. [Monopoli, Delia; Decarolis, Nicola Mattia; Giudice, Antonella; Stanyevic, Brigida; Esposito, Susanna] Univ Hosp Parma, Dept Med & Surg, Pediat Clin, I-43126 Parma, Italy. [Biasucci, Giacomo] Univ Parma, Dept Med & Surg, I-43126 Parma, Italy. C3 Guglielmo da Saliceto Hospital; University of Parma; University Hospital of Parma; University of Parma RP Esposito, S (通讯作者)，Univ Hosp Parma, Dept Med & Surg, Pediat Clin, I-43126 Parma, Italy. 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Martinez-Beamonte, Roberto Ripalda, Marina Herrero-Continente, Tania Barranquero, Cristina Davalos, Alberto Lopez de las Hazas, Maria Carmen Alvarez-Lanzarote, Ignacio Cristina Sanchez-Gimeno, Ana Raso, Javier Arnal, Carmen Surra, Joaquin C. Osada, Jesus Navarro, Maria A. TI Pulsed electric field increases the extraction yield of extra virgin olive oil without loss of its biological properties SO FRONTIERS IN NUTRITION LA English DT Article DE extra virgin olive oil; Empeltre; microRNA; pulsed electric field; hepatic steatosis; atherosclerosis; phytosterols ID ATHEROSCLEROTIC LESION; BIOACTIVE COMPOUNDS; MEDITERRANEAN DIET; PREVENTION; QUALITY; IMPACT; GROWTH AB IntroductionPulsed electric field (PEF) has been used for improving extraction of extra virgin olive oil (EVOO). However, the biological changes induced by the consumption of pulsed electric field-obtained extra virgin olive oil (PEFEVOO) have not been studied yet. Materials and methodsEVOO oils from Empeltre variety were prepared by standard (STD) cold pressure method involving crushing of the olives, malaxation and decanting and by this procedure including an additional step of PEF treatment. Chemical analyses of EVOO oils were done. Male and female Apoe-deficient mice received diets differing in both EVOOs for 12 weeks, and their plasma, aortas and livers were analyzed. ResultsPEF application resulted in a 17% increase in the oil yield and minimal changes in chemical composition regarding phytosterols, phenolic compounds and microRNA. Only in females mice consuming PEF EVOO, a decreased plasma total cholesterol was observed, without significant changes in atherosclerosis and liver steatosis. ConclusionPEF technology applied to EVOO extraction maintains the EVOO quality and improves the oil yield. The equivalent biological effects in atherosclerosis and fatty liver disease of PEF-obtained EVOO further support its safe use as a food. C1 [Martinez-Beamonte, Roberto; Ripalda, Marina; Herrero-Continente, Tania; Barranquero, Cristina; Osada, Jesus; Navarro, Maria A.] Univ Zaragoza, Fac Vet, Inst Invest Sanitaria Aragon, Dept Bioquim & Biol Mol & Celular, Zaragoza, Spain. [Martinez-Beamonte, Roberto; Barranquero, Cristina; Alvarez-Lanzarote, Ignacio; Cristina Sanchez-Gimeno, Ana; Raso, Javier; Arnal, Carmen; Surra, Joaquin C.; Osada, Jesus; Navarro, Maria A.] Univ Zaragoza, Inst Agroalimentario Aragon, CITA, Zaragoza, Spain. [Martinez-Beamonte, Roberto; Barranquero, Cristina; Surra, Joaquin C.; Osada, Jesus; Navarro, Maria A.] Inst Salud Carlos III, CIBER Fisiopatol La Obesidad & Nutr, Madrid, Spain. [Davalos, Alberto; Lopez de las Hazas, Maria Carmen] CEI UAM CSIC, Lab Epigenet Lipid Metab, Inst Madrileno Estudios Avanzados IMDEA Alimentac, Madrid, Spain. [Alvarez-Lanzarote, Ignacio; Cristina Sanchez-Gimeno, Ana; Raso, Javier] Univ Zaragoza, Fac Vet, Dept Prod Anim & Ciencia Los Alimentos, Zaragoza, Spain. [Arnal, Carmen] Univ Zaragoza, Fac Vet, Inst Invest Sanitaria Aragon, Dept Patol Anim, Zaragoza, Spain. [Surra, Joaquin C.] Univ Zaragoza, Inst Invest Sanitaria Aragon, Dept Prod Anim & Ciencia Los Alimentos, Escuela Politecn Super Huesca, Zaragoza, Spain. C3 University of Zaragoza; University of Zaragoza; Instituto de Salud Carlos III; Consejo Superior de Investigaciones Cientificas (CSIC); University of Zaragoza; University of Zaragoza; University of Zaragoza RP Osada, J (通讯作者)，Univ Zaragoza, Fac Vet, Inst Invest Sanitaria Aragon, Dept Bioquim & Biol Mol & Celular, Zaragoza, Spain.; Osada, J (通讯作者)，Univ Zaragoza, Inst Agroalimentario Aragon, CITA, Zaragoza, Spain.; Osada, J (通讯作者)，Inst Salud Carlos III, CIBER Fisiopatol La Obesidad & Nutr, Madrid, Spain. EM josada@unizar.es RI Alvarez, Ignacio/M-1236-2015; BARRANQUERO CORTES, CRISTINA/LSM-4589-2024; López de las Hazas, María Carmen/L-3033-2017; Navarro, Ángeles/AAG-6089-2019; Martinez-Beamonte, Roberto/E-4981-2016; gimeno, ana/I-3915-2019; Davalos, Alberto/AAA-9949-2021 OI BARRANQUERO CORTES, CRISTINA/0000-0002-8442-8041; López de las Hazas, María Carmen/0000-0001-8199-6724; CR Abenoza M, 2013, FOOD BIOPROCESS TECH, V6, P1367, DOI 10.1007/s11947-012-0817-6 Acín S, 2007, J NUTR BIOCHEM, V18, P418, DOI 10.1016/j.jnutbio.2006.08.005 Arbonés-Mainar JM, 2006, ATHEROSCLEROSIS, V189, P318, DOI 10.1016/j.atherosclerosis.2006.01.015 Bejaoui MA, 2018, INNOV FOOD SCI EMERG, V47, P136, DOI 10.1016/j.ifset.2018.02.002 Barba FJ, 2014, STUD NAT PROD CHEM, V41, P321, DOI 10.1016/B978-0-444-63294-4.00011-5 Chin AR, 2016, CELL RES, V26, P217, DOI 10.1038/cr.2016.13 Commission Regulation (EEC), 1991, OFFICIAL J EUROPEAN OFF J EUR COMMUNITIE del Pozo-Acebo L, 2022, PHARMACOL RES, V185, DOI 10.1016/j.phrs.2022.106472 del Pozo-Acebo L, 2021, BRIT J PHARMACOL, V178, P2218, DOI 10.1111/bph.15421 del Saz-Lara A, 2022, ADV NUTR, V13, P2039, DOI 10.1093/advances/nmac067 Delgado-Lista J, 2022, LANCET, V399, P1876, DOI 10.1016/S0140-6736(22)00122-2 Duivenvoorden R, 2009, ATHEROSCLEROSIS, V206, P8, DOI 10.1016/j.atherosclerosis.2008.12.009 Estruch R, 2018, NEW ENGL J MED, V378, DOI [10.1056/NEJMoa1200303, 10.1056/NEJMoa1800389, 10.1056/nejmoa1800389] Gabás-Rivera C, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0104224 Gaforio JJ, 2019, NUTRIENTS, V11, DOI 10.3390/nu11092039 Guasch-Ferré M, 2021, J INTERN MED, V290, P549, DOI 10.1111/joim.13333 Guasch-Ferré M, 2022, J AM COLL CARDIOL, V79, P101, DOI 10.1016/j.jacc.2021.10.041 Guderjan M, 2005, J FOOD ENG, V67, P281, DOI 10.1016/j.jfoodeng.2004.04.029 Guillen N, 2008, ATHEROSCLEROSIS, V197, P72, DOI 10.1016/j.atherosclerosis.2007.08.008 Guillén N, 2009, REV ESP CARDIOL, V62, P294, DOI 10.1016/S0300-8932(09)70374-4 Gylling H, 2014, ATHEROSCLEROSIS, V232, P346, DOI 10.1016/j.atherosclerosis.2013.11.043 Hermoso M., 1991, ELABORACION ACEITE O, P5 KEYS A, 1986, AM J EPIDEMIOL, V124, P903, DOI 10.1093/oxfordjournals.aje.a114480 Lou-Bonafonte JM, 2012, MOL NUTR FOOD RES, V56, P1043, DOI 10.1002/mnfr.201100668 Markellos C, 2022, PLOS ONE, V17, DOI 10.1371/journal.pone.0261649 Martines Suarez J. 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Nutr. PD NOV 22 PY 2022 VL 9 AR 1065543 DI 10.3389/fnut.2022.1065543 PG 10 WC Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Nutrition & Dietetics GA 6T1EB UT WOS:000893424000001 PM 36483924 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Cappello, T Giannetto, A Parrino, V De Marco, G Mauceri, A Maisano, M AF Cappello, Tiziana Giannetto, Alessia Parrino, Vincenzo De Marco, Giuseppe Mauceri, Angela Maisano, Maria TI Food safety using NMR-based metabolomics: Assessment of the Atlantic bluefin tuna, Thunnus thynnus, from the Mediterranean Sea SO FOOD AND CHEMICAL TOXICOLOGY LA English DT Article DE Food safety; Mediterranean sea; Pelagic fish; Bluefin tuna; NMR-Based metabolomics; Metabolic pathways ID FISH LIZA-AURATA; PETROCHEMICAL CONTAMINATION; HEAVY-METALS; FATTY-ACIDS; METABOLISM; ACCUMULATION; CONSUMPTION; MECHANISMS; H-1-NMR; BIOACCUMULATION AB Seafood is a valuable component of human diet because of its nutritional properties. The Atlantic bluefin tuna Thunnus thynnus is a scombroid fish highly appreciated as seafood worldwide. Being a top pelagic predator, concerns have been raised over human health risks due to its consumption. Therefore, herein it was comprehensively evaluated the health status and potential metabolite shifts between sexes of bluefin tuna from the Mediterranean Sea, proved to bioaccumulate environmental obesogens, namely polychlorinated biphenyls (PCBs) and organochlorine pesticides (OCPs) at hepatic level. To this aim, nuclear magnetic resonance (NMR)based metabolomics was applied on liver of post-spawning tuna. Findings from this study pointed out that hepatic bioaccumulation of PCBs and OCPs induced differential metabolic disturbances between sexes, attributable to the reproductive stage at which tuna were caught. Alterations were mainly found in energy-producing metabolic pathways (with changes in acetate, acetoacetate, malonate, and lactate), amino acid (with changes in BCAA, alanine, sarcosine, and tyrosine), and lipid (with changes in choline and phosphocholine) metabolism, with activation of fatty acids biosynthesis and ketogenesis in male tuna. Overall, according to the current European legislation on maximum levels of contaminants in seafood, the consumption of bluefin tuna does not represent a risk for human health. C1 [Cappello, Tiziana; Giannetto, Alessia; Parrino, Vincenzo; De Marco, Giuseppe; Mauceri, Angela; Maisano, Maria] Univ Messina, Dept Chem Biol Pharmaceut & Environm Sci, Viale F Stagno Alcontres 31, I-98166 Messina, Italy. C3 University of Messina RP Cappello, T; Maisano, M (通讯作者)，Univ Messina, Dept Chem Biol Pharmaceut & Environm Sci, Viale F Stagno Alcontres 31, I-98166 Messina, Italy. EM tcappello@unime.it; mmaisano@unime.it RI CAPPELLO, TIZIANA/J-6902-2016; Giannetto, Alessia/AAA-6735-2019; DE MARCO, GIUSEPPE/AAR-4765-2021; PARRINO, Vincenzo/O-8408-2019 OI CAPPELLO, TIZIANA/0000-0002-7790-6324; MAISANO, Maria/0000-0003-2517-5117; DE MARCO, GIUSEPPE/0000-0003-1381-8146; PARRINO, Vincenzo/0000-0001-8331-212X CR Adel M, 2018, FOOD CHEM TOXICOL, V113, P198, DOI 10.1016/j.fct.2018.01.027 Aru V, 2018, J FOOD COMPOS ANAL, V69, P13, DOI 10.1016/j.jfca.2018.01.018 Aru V, 2016, FOOD CHEM, V205, P58, DOI 10.1016/j.foodchem.2016.02.152 Brandao F, 2015, METALLOMICS, V7, P1352, DOI [10.1039/c5mt00090d, 10.1039/C5MT00090D] Brennan L, 2013, BIOCHEM SOC T, V41, P670, DOI 10.1042/BST20120350 Cappello T, 2017, COMP BIOCHEM PHYS C, V199, P20, DOI 10.1016/j.cbpc.2017.02.002 Cappello T, 2017, ECOTOX ENVIRON SAFE, V143, P166, DOI 10.1016/j.ecoenv.2017.05.031 Cappello T, 2017, ECOTOX ENVIRON SAFE, V142, P417, DOI 10.1016/j.ecoenv.2017.04.040 Cappello T, 2016, ENVIRON POLLUT, V219, P139, DOI 10.1016/j.envpol.2016.10.033 Cappello T, 2016, SCI TOTAL ENVIRON, V548, P13, DOI 10.1016/j.scitotenv.2016.01.008 Cappello T, 2015, COMP BIOCHEM PHYS C, V169, P7, DOI 10.1016/j.cbpc.2014.12.006 Cappello T, 2013, MAR POLLUT BULL, V77, P132, DOI 10.1016/j.marpolbul.2013.10.019 Cederholm T, 2017, CURR OPIN CLIN NUTR, V20, P104, DOI 10.1097/MCO.0000000000000350 Conti GO, 2012, B ENVIRON CONTAM TOX, V88, P946, DOI 10.1007/s00128-012-0611-1 Cubero-Leon E, 2014, FOOD RES INT, V60, P95, DOI 10.1016/j.foodres.2013.11.041 da Silva RP, 2014, BBA-MOL CELL BIOL L, V1841, P1639, DOI 10.1016/j.bbalip.2014.09.001 Dirinck E, 2011, OBESITY, V19, P709, DOI 10.1038/oby.2010.133 Fasulo S, 2012, ECOTOX ENVIRON SAFE, V84, P139, DOI 10.1016/j.ecoenv.2012.07.001 Hellberg RS, 2012, COMPR REV FOOD SCI F, V11, P490, DOI 10.1111/j.1541-4337.2012.00200.x Iacono F, 2010, COMP BIOCHEM PHYS A, V157, pS50, DOI 10.1016/j.cbpa.2010.06.143 Karl H, 2016, CHEMOSPHERE, V149, P294, DOI 10.1016/j.chemosphere.2016.01.052 Kokushi E, 2017, ENVIRON SCI POLLUT R, V24, P27678, DOI 10.1007/s11356-016-6425-7 Lin CY, 2006, J PESTIC SCI, V31, P245, DOI 10.1584/jpestics.31.245 Maisano M, 2017, MAR ENVIRON RES, V128, P114, DOI 10.1016/j.marenvres.2016.03.008 Maisano M, 2016, MAR ENVIRON RES, V121, P40, DOI 10.1016/j.marenvres.2016.03.003 Mourente G, 2001, FISH PHYSIOL BIOCHEM, V24, P351, DOI 10.1023/A:1015011609017 PEREIRA C, 1995, J EXP ZOOL, V271, P425, DOI 10.1002/jez.1402710603 Picone G, 2011, NUTRIENTS, V3, P212, DOI 10.3390/nu3020212 Rui LY, 2014, COMPR PHYSIOL, V4, P177, DOI [10.1002/j.2040-4603.2014.tb00548.x, 10.1002/cphy.c130024] Ruxton CHS, 2004, J HUM NUTR DIET, V17, P449, DOI [10.1111/j.1365-277X.2004.00552.x, 10.1111/j.1365-277X.2007.00770.x] Santamaria N, 2009, J APPL ICHTHYOL, V25, P38, DOI 10.1111/j.1439-0426.2009.01191.x Sarà G, 2007, J APPL ICHTHYOL, V23, P122, DOI 10.1111/j.1439-0426.2006.00829.x Savorani F, 2013, FOOD RES INT, V54, P1131, DOI 10.1016/j.foodres.2012.12.025 Sprague M, 2012, ENVIRON POLLUT, V171, P61, DOI 10.1016/j.envpol.2012.07.021 Storelli MM, 2008, ENVIRON INT, V34, P509, DOI 10.1016/j.envint.2007.11.006 Tansey JT, 2004, IUBMB LIFE, V56, P379, DOI 10.1080/15216540400009968 Tocher DR, 2003, REV FISH SCI, V11, P107, DOI 10.1080/713610925 Ueno D, 2002, MAR POLLUT BULL, V45, P254, DOI 10.1016/S0025-326X(02)00109-1 Wu HF, 2008, ANAL BIOCHEM, V372, P204, DOI 10.1016/j.ab.2007.10.002 Xu HD, 2015, AQUAT TOXICOL, V159, P69, DOI 10.1016/j.aquatox.2014.11.020 NR 40 TC 63 Z9 67 U1 1 U2 49 PU PERGAMON-ELSEVIER SCIENCE LTD PI OXFORD PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND SN 0278-6915 EI 1873-6351 J9 FOOD CHEM TOXICOL JI Food Chem. Toxicol. PD MAY PY 2018 VL 115 BP 391 EP 397 DI 10.1016/j.fct.2018.03.038 PG 7 WC Food Science & Technology; Toxicology WE Science Citation Index Expanded (SCI-EXPANDED) SC Food Science & Technology; Toxicology GA GG4DS UT WOS:000432644400039 PM 29601848 DA 2026-02-02 ER PT J AU Rondanelli, M Gasparri, C Razza, C Ferraris, C Perna, S Ferrarotti, I Corsico, AG AF Rondanelli, Mariangela Gasparri, Clara Razza, Claudia Ferraris, Cinzia Perna, Simone Ferrarotti, Ilaria Corsico, Angelo Guido TI Practical dietary advices for subjects with alpha-1 antitrypsin deficiency SO BIOMEDICINE & PHARMACOTHERAPY LA English DT Review DE Alpha-1 antitrypsin deficiency; Chronic obstructive pulmonary disease; Dietary advice ID OBSTRUCTIVE PULMONARY-DISEASE; FATTY-LIVER-DISEASE; LIFE-STYLE INTERVENTION; BONE-MINERAL DENSITY; BODY-MASS INDEX; NUTRITIONAL-STATUS; NONALCOHOLIC STEATOHEPATITIS; MEDITERRANEAN DIET; DOUBLE-BLIND; VITAMIN-E AB Congenital alpha-1 antitrypsin deficiency (AATD) is a rare inherited disorder caused by the mutation of the SERPINA1 gene on chromosome 14. At pulmonary level, AAT deficiency leads to an increased risk of chronic obstructive pulmonary disease (COPD) and emphysema, starting from the third-fourth decade of life. At hepatic level, some variants of the allelic, in particular PI*Z, cause a conformational change of the AAT molecule, which polymerizes within the hepatocytes. Excessive hepatic accumulation of these abnormal molecules can lead to liver disease in both adults and children, with clinical presentation ranging from cholestatic jaundice in the newborn to abnormal blood indices of liver function in children and adults, up to fatty liver, cirrhosis and hepatocarcinoma. Nutritional interventions in AATD aim to provide the necessary calories, stop protein catab-olism, prevent and treat malnutrition as in the case of common COPD, and even take into account any liver disease that is a distinctive trait, compared to common COPD. Actually, there is a lack of formal research regarding the effects of specific nutritional recommendations in patients with AATD, proper eating habits may help to preserve lung and liver function. For practical dietary advice in patients with AATD and COPD, recently a food pyramid proposal has been published. It has been observed that there is a marked overlap between AATD liver disease and obesity-related liver disease, suggesting shared molecular basis and, therefore, similar nutri-tional strategies. In this narrative review dietary advice for all possible stages of liver disease have been reported. C1 [Rondanelli, Mariangela] IRCCS Mondino Fdn, I-27100 Pavia, Italy. [Rondanelli, Mariangela] Univ Pavia, Dept Publ Hlth, Unit Human & Clin Nutr, Expt & Forens Med, I-27100 Pavia, Italy. [Gasparri, Clara; Razza, Claudia] Univ Pavia, Azienda Serv Persona, Endocrinol & Nutr Unit, Ist St Margherita, I-27100 Pavia, Italy. [Ferraris, Cinzia] Univ Pavia, Dept Publ Hlth Expt & Forens Med, Lab Food Educ & Sport Nutr, I-27100 Pavia, Italy. [Perna, Simone] Univ Bahrain, Coll Sci, Dept Biol, Sakhir 32038, Bahrain. [Ferrarotti, Ilaria; Corsico, Angelo Guido] Univ Pavia, Ctr Diag Inherited Alpha 1 Antitrypsin Deficiency, Dept Internal Med & Therapeut, I-27100 Pavia, Italy. [Ferrarotti, Ilaria; Corsico, Angelo Guido] IRCCS Policlin San Matteo Fdn, Div Resp Dis, I-27100 Pavia, Italy. C3 IRCCS Fondazione Casimiro Mondino; University of Pavia; University of Pavia; University of Pavia; University of Bahrain; University of Pavia; IRCCS Fondazione San Matteo RP Rondanelli, M (通讯作者)，IRCCS Mondino Fdn, I-27100 Pavia, Italy. 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Pharmacother. PD JUL PY 2023 VL 163 AR 114753 DI 10.1016/j.biopha.2023.114753 EA APR 2023 PG 9 WC Medicine, Research & Experimental; Pharmacology & Pharmacy WE Science Citation Index Expanded (SCI-EXPANDED) SC Research & Experimental Medicine; Pharmacology & Pharmacy GA G7SI5 UT WOS:000991108100001 PM 37119738 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Caserza, L Casula, M Elia, E Bonaventura, A Liberale, L Bertolotto, M Artom, N Minetti, S Contini, P Verzola, D Pontremoli, R Viazzi, F Viviani, GL Bertolini, S Pende, A Pisciotta, L Montecucco, F Carbone, F AF Caserza, Lara Casula, Matteo Elia, Edorado Bonaventura, Aldo Liberale, Luca Bertolotto, Maria Artom, Nathan Minetti, Silvia Contini, Paola Verzola, Daniela Pontremoli, Roberto Viazzi, Franesca Viviani, Giorgio L. Bertolini, Stefano Pende, Aldo Pisciotta, Livia Montecucco, Fabrizio Carbone, Federico TI Serum osteopontin predicts glycaemic profile improvement in metabolic syndrome: A pilot study SO EUROPEAN JOURNAL OF CLINICAL INVESTIGATION LA English DT Article DE diabetes; glycaemia; impaired fasting glucose; mediterranean diet; metabolic syndrome; osteopontin ID IMPAIRED FASTING GLUCOSE; FATTY LIVER-DISEASE; C-REACTIVE PROTEIN; INSULIN-RESISTANCE; INFLAMMATION; EXPRESSION; ARTERY; RISK; MACROPHAGE; PHENOTYPES AB Prediabetes is often observed in patients with Metabolic Syndrome (MetS) and might be associated with metabolic and inflammatory alterations. Here, we investigated whether the inflammatory molecule osteopontin (OPN) might have a prognostic impact in a cohort of MetS patients (n = 85) with baseline normal glycaemia or impaired fasting glucose (IFG) over one year of recommended pharmacological treatments and Mediterranean diet. Patients were then followed up for 12 months with intermediate evaluation after 6 months. At all time points, anthropometric and clinical data were recorded, alongside with haematological and biochemical profiles, including serum concentrations of OPN. As expected, Mediterranean diet improves glycaemic profile in patients with IFG. Baseline serum OPN failed to be associated with baseline anthropometric or biochemical variables. At baseline, higher levels of OPN were shown in patients with IFG as compared to normal glycaemia. Two distinct subgroups of patients in whom OPN decreased or remained stable/increased at follow-up were identified. When higher serum OPN levels were observed at baseline, greater reduction was observed at 1-year follow-up. Reduction in circulating OPN levels was associated with metabolic improvement in terms of blood pressure, LDL-c, HDL-c, and glycaemia. At both univariate and adjusted logistic regression analyses, serum OPN emerged as an independent predictor of glycaemic profile improvement at 1-year follow-up (adjOR 1.05 [1.00-1.10];P = .041). In conclusion, pharmacological and dietetic interventions improved glycaemic profile in patients with MetS. In particular, glycaemic improvement was demonstrated in patients who also reduce circulating OPN levels. Higher OPN levels at baseline predict normalization of glycaemic profile. C1 [Caserza, Lara; Bonaventura, Aldo; Liberale, Luca; Bertolotto, Maria; Minetti, Silvia; Montecucco, Fabrizio; Carbone, Federico] Univ Genoa, Dept Internal Med, Clin Internal Med 1, Genoa, Italy. [Casula, Matteo; Elia, Edorado] Dept Internal Med, Div Cardiol, Turin, Italy. [Bonaventura, Aldo] Virginia Commonwealth Univ, Dept Internal Med, Div Cardiol, Pauley Heart Ctr, Richmond, VA USA. [Liberale, Luca] Univ Zurich, Ctr Mol Cardiol, Zurich, Switzerland. [Artom, Nathan] Osped S Paolo Savona, Dept Internal Med, Savona, Italy. [Contini, Paola; Verzola, Daniela; Pontremoli, Roberto; Viazzi, Franesca; Viviani, Giorgio L.; Bertolini, Stefano; Pende, Aldo; Pisciotta, Livia] Univ Genoa, Dept Internal Med, Genoa, Italy. [Contini, Paola; Pontremoli, Roberto; Viazzi, Franesca; Pende, Aldo] IRCCS Osped Policlin San Martino Genoa, Genoa, Italy. [Montecucco, Fabrizio; Carbone, Federico] IRCCS Osped Policlin San Martino Genoa Italian Ca, 10 Largo Benzi, I-16132 Genoa, Italy. [Montecucco, Fabrizio] Univ Genoa, Clin Internal Med 1, Ctr Excellence Biomed Res CEBR, Genoa, Italy. C3 University of Genoa; Virginia Commonwealth University; University of Zurich; University of Genoa; University of Genoa; IRCCS AOU San Martino IST; University of Genoa; IRCCS AOU San Martino IST; University of Genoa RP Carbone, F (通讯作者)，IRCCS Osped Policlin San Martino Genoa Italian Ca, 10 Largo Benzi, I-16132 Genoa, Italy. 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J. Clin. Invest. PD MAR PY 2021 VL 51 IS 3 AR e13403 DI 10.1111/eci.13403 EA SEP 2020 PG 8 WC Medicine, General & Internal; Medicine, Research & Experimental WE Science Citation Index Expanded (SCI-EXPANDED) SC General & Internal Medicine; Research & Experimental Medicine GA QK9MD UT WOS:000572540500001 PM 32918277 DA 2026-02-02 ER PT J AU Errazuriz, I Dube, S Slama, M Visentin, R Nayar, S O'Connor, H Cobelli, C Das, SK Basu, A Kremers, WK Port, J Basu, R AF Errazuriz, Isabel Dube, Simmi Slama, Michael Visentin, Roberto Nayar, Sunita O'Connor, Helen Cobelli, Claudio Das, Swapan Kumar Basu, Ananda Kremers, Walter Karl Port, John Basu, Rita TI Randomized Controlled Trial of a MUFA or Fiber-Rich Diet on Hepatic Fat in Prediabetes SO JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM LA English DT Article ID ALANINE AMINOTRANSFERASE LEVELS; LIVER-DISEASE; INSULIN SENSITIVITY; MEDITERRANEAN DIET; GLUCOSE-TOLERANCE; NATURAL-HISTORY; CARBOHYDRATE; WEIGHT; ACID; RESTRICTION AB Context: Increased prevalence of type 2 diabetes mellitus and prediabetes worldwide is attributed in part to an unhealthy diet. Objective: To evaluate whether 12 weeks of high monounsaturated fatty acid (MUFA) or fiber-rich weight-maintenance diet lowers hepatic fat and improves glucose tolerance in people with prediabetes. Design: Subjects underwent a [6, 6-H-2(2)]-labeled 75-g oral glucose tolerance test to estimate hepatic insulin sensitivity and liver fat fraction (LFF) using magnetic resonance spectroscopy before and after intervention. Setting: Mayo Clinic Clinical Research Trials Unit. Participants: 43 subjects with prediabetes. Intervention: Subjects were randomized into three isocaloric weight-maintaining diets containing MUFA (olive oil), extra fiber, and standard US food (control-habitual diet). Outcome Measures: LFF, glucose tolerance, and indices of insulin action and secretion. Results: Body weight was maintained constant in all groups during the intervention. Glucose and hormonal concentrations were similar in all groups before, and unchanged after, 12 weeks of intervention. LFF was significantly lower after intervention in the MUFA group (P < 0.0003) but remained unchanged in the fiber (P = 0.25) and control groups (P = 0.45). After 12 weeks, LFF was significantly lower in the MUFA than in the control group (P = 0.01), but fiber and control groups did not differ (P = 0.41). Indices of insulin action and secretion were not significantly different between the MUFA and control groups after intervention (P >= 0.11), but within-group comparison showed higher hepatic (P = 0.01) and total insulin sensitivity (P < 0.04) with MUFA. Conclusions: Twelve weeks of a MUFA diet decreases hepatic fat and improves both hepatic and total insulin sensitivity. C1 [Errazuriz, Isabel; Dube, Simmi; Slama, Michael; Basu, Ananda; Basu, Rita] Mayo Clin, Endocrine Res Unit, Rochester, MN 55905 USA. [Visentin, Roberto; Cobelli, Claudio] Univ Padua, Dept Informat Engn, I-35131 Padua, Italy. [Nayar, Sunita; O'Connor, Helen] Mayo Clin, Clin Res & Trials Unit, Rochester, MN 55905 USA. [Das, Swapan Kumar] Wake Forest Sch Med, Dept Internal Med, Endocrinol & Metab, Winston Salem, NC 27109 USA. [Kremers, Walter Karl] Mayo Clin, Dept Hlth Sci Res, Rochester, MN 55905 USA. [Port, John] Mayo Clin, Dept Radiol, Rochester, MN 55905 USA. C3 Mayo Clinic; University of Padua; Mayo Clinic; Wake Forest University; Mayo Clinic; Mayo Clinic RP Basu, R (通讯作者)，Mayo Clin, Nutr, Diabet, Endocrine Res Unit,Div Endocrinol, Joseph 5-194,200 1st St SW, Rochester, MN 55905 USA. EM basu.rita@mayo.edu RI Port, John D/I-7940-2014; Das, Swapan/IVH-2856-2023; Visentin, Roberto/J-4715-2016 OI Port, John D/0000-0002-4237-7776; Das, Swapan/0000-0002-2197-8855; Slama, Michael/0000-0002-0808-3547; Visentin, Roberto/0000-0002-5848-5990 FU National Institutes of Health from the National Center [R01 DK29953, R01 DK090111]; Dry Beans Health Research Foundation; Mayo Metabolomics Core Unit [U24DK100469]; National Center for Advancing Translational Science, a component of the National Institutes of Health [UL1 TR000135]; National Institute of Diabetes and Digestive and Kidney Diseases [R01DK029953] Funding Source: NIH RePORTER FX This study was supported by National Institutes of Health Grants R01 DK29953 (to R.B.) and R01 DK090111 (to S.K.D.) and Grant UL1 TR000135 from the National Center for Advancing Translational Science, a component of the National Institutes of Health; the Dry Beans Health Research Foundation; and the Mayo Metabolomics Core Unit Grant U24DK100469. CR Barnard ND, 2005, AM J MED, V118, P991, DOI 10.1016/j.amjmed.2005.03.039 Basu R, 2007, DIABETES, V56, P753, DOI 10.2337/db06-1504 Bjermo H, 2012, AM J CLIN NUTR, V95, P1003, DOI 10.3945/ajcn.111.030114 Bozzetto L, 2016, DIABETOLOGIA, V59, P2697, DOI 10.1007/s00125-016-4110-5 Bozzetto L, 2012, DIABETES CARE, V35, P1429, DOI 10.2337/dc12-0033 Chalasani N, 2012, AM J GASTROENTEROL, V107, P811, DOI 10.1038/ajg.2012.128 Chong MFF, 2008, AM J CLIN NUTR, V87, P817, DOI 10.1093/ajcn/87.4.817 de Vegt F, 2001, JAMA-J AM MED ASSOC, V285, P2109, DOI 10.1001/jama.285.16.2109 Dinneen SF, 1998, DIABETES CARE, V21, P1408, DOI 10.2337/diacare.21.9.1408 Dongiovanni P, 2013, CURR PHARM DESIGN, V19, P5219, DOI 10.2174/13816128113199990381 Fraser A, 2008, DIABETOLOGIA, V51, P1616, DOI 10.1007/s00125-008-1049-1 Gregg E, 2014, THERAPY DIABETES MEL, P77 Hamilton G, 2009, J MAGN RESON IMAGING, V30, P145, DOI 10.1002/jmri.21809 Kaline K, 2007, HORM METAB RES, V39, P687, DOI 10.1055/s-2007-985811 Kristal AR, 2014, J ACAD NUTR DIET, V114, P613, DOI 10.1016/j.jand.2013.11.017 Lee JJ, 2015, AM J CLIN NUTR, V101, P34, DOI 10.3945/ajcn.114.092262 Loomba R, 2014, HEPATOLOGY, V60, P1920, DOI 10.1002/hep.27362 Man CD, 2008, AM J PHYSIOL-ENDOC M, V295, pE1152, DOI 10.1152/ajpendo.00486.2007 Meigs JB, 2003, DIABETES, V52, P1475, DOI 10.2337/diabetes.52.6.1475 Ortiz-Lopez C, 2012, DIABETES CARE, V35, P873, DOI 10.2337/dc11-1849 Papandreou D, 2015, WORLD J HEPATOL, V7, P575, DOI 10.4254/wjh.v7.i3.575 Persson XMT, 2010, J LIPID RES, V51, P2761, DOI 10.1194/jlr.M008011 Promrat K, 2010, HEPATOLOGY, V51, P121, DOI 10.1002/hep.23276 Ratziu V, 2010, J HEPATOL, V53, P372, DOI 10.1016/j.jhep.2010.04.008 Ryan MC, 2013, J HEPATOL, V59, P138, DOI 10.1016/j.jhep.2013.02.012 Ryan MC, 2007, DIABETES CARE, V30, P1075, DOI 10.2337/dc06-2169 SAAD MF, 1988, NEW ENGL J MED, V319, P1500, DOI 10.1056/NEJM198812083192302 Speliotes EK, 2011, PLOS GENET, V7, DOI 10.1371/journal.pgen.1001324 Thoma C, 2012, J HEPATOL, V56, P255, DOI 10.1016/j.jhep.2011.06.010 Utzschneider KM, 2013, BRIT J NUTR, V109, P1096, DOI 10.1017/S0007114512002966 van Herpen NA, 2011, J CLIN ENDOCR METAB, V96, pE691, DOI 10.1210/jc.2010-2243 VIGUE JT, 1978, AGRON J, V70, P1107, DOI 10.2134/agronj1978.00021962007000060052x Visentin R, 2015, AM J PHYSIOL-ENDOC M, V309, pE161, DOI 10.1152/ajpendo.00358.2014 Westerbacka J, 2005, J CLIN ENDOCR METAB, V90, P2804, DOI 10.1210/jc.2004-1983 Yki-Järvinen H, 2015, NUTRIENTS, V7, P9127, DOI 10.3390/nu7115454 Yu HY, 2014, J CLIN MED, V3, P1050, DOI 10.3390/jcm3031050 NR 36 TC 65 Z9 71 U1 0 U2 21 PU ENDOCRINE SOC PI WASHINGTON PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA SN 0021-972X EI 1945-7197 J9 J CLIN ENDOCR METAB JI J. Clin. Endocrinol. Metab. PD MAY 1 PY 2017 VL 102 IS 5 BP 1765 EP 1774 DI 10.1210/jc.2016-3722 PG 10 WC Endocrinology & Metabolism WE Science Citation Index Expanded (SCI-EXPANDED) SC Endocrinology & Metabolism GA EW6IX UT WOS:000402614700040 PM 28323952 OA Bronze DA 2026-02-02 ER PT J AU Barbaro, B Toietta, G Maggio, R Arciello, M Tarocchi, M Galli, A Balsano, C AF Barbaro, Barbara Toietta, Gabriele Maggio, Roberta Arciello, Mario Tarocchi, Mirko Galli, Andrea Balsano, Clara TI Effects of the Olive-Derived Polyphenol Oleuropein on Human Health SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES LA English DT Review DE olive; oleuropein; Mediterranean diet; polyphenols; antioxidant; anti-inflammatory; anticancer; non-alcoholic fatty liver disease ID LOW-DENSITY-LIPOPROTEIN; INTEGRASE INHIBITORS OLEUROPEIN; MOLECULE HIV-1 FUSION; AMYLOID-BETA-PEPTIDE; PHENOLIC-COMPOUNDS; LEAF EXTRACT; SPINAL-CORD; IN-VITRO; PROLONGED-SURVIVAL; OIL PHENOLS AB The use of the products derived from the olive tree on human health dates back centuries. In several civilizations, the olive tree had and still has a very strong cultural and religious symbolism. Notably, the official seal and emblem of the World Health Organization features the rod of Asclepius over a world map surrounded by olive tree branches, chosen as a symbol of peace and health. Recently, accumulating experimental, clinical and epidemiological data have provided support to the traditional beliefs of the beneficial effect provided by olive derivates. In particular, the polyphenols present in olive leaves, olives, virgin (unrefined) olive oil and olive mill waste are potent antioxidant and radical scavengers with anti-tumor and anti-inflammatory properties. Here, we review the positive impact on human health of oleuropein, the most prevalent polyphenol present in olives. In addition, we provide data collected in our laboratory on the role of oleuropein in counteracting lipid accumulation in a mouse model of non-alcoholic fatty liver disease. C1 [Barbaro, Barbara; Maggio, Roberta; Arciello, Mario] Francesco Balsano Fdn, Lab Mol Virol & Oncol, I-00198 Rome, Italy. [Toietta, Gabriele] Regina Elena Natl Canc Inst IRCCS, Dept Expt Oncol, I-00144 Rome, Italy. [Arciello, Mario] Univ Roma La Sapienza, Dept Internal Med & Med Specialties, I-00161 Rome, Italy. [Tarocchi, Mirko; Galli, Andrea] Univ Florence, Dept Expt & Clin Biomed Sci, I-50139 Florence, Italy. [Balsano, Clara] CNR, Inst Biol Mol Med & Nanobiotechnol IBMN, I-00185 Rome, Italy. C3 Sapienza University Rome; University of Florence; Consiglio Nazionale delle Ricerche (CNR) RP Balsano, C (通讯作者)，CNR, Inst Biol Mol Med & Nanobiotechnol IBMN, I-00185 Rome, Italy. EM barbara.barbaro@fondazioneandreacesalpino.it; toietta@ifo.it; roberta.maggio@fondazioneandreacesalpino.it; mario.arciello@uniroma1.it; mirko.tarocchi@unifi.it; andrea.galli@unifi.it; clara.balsano@cnr.it RI ; Toietta, Gabriele/B-1358-2010; Galli, Anea/AAC-1623-2019; Arciello, Mario/G-9278-2016; Barbaro, Barbara/K-5588-2016; Balsano, Clara/MCY-5404-2025 OI TAROCCHI, MIRKO/0000-0002-7767-5116; MAGGIO, ROBERTA/0000-0001-8319-4418; Toietta, Gabriele/0000-0003-4182-2468; Galli, Anea/0000-0001-5416-6290; Arciello, Mario/0000-0001-8599-6297; Barbaro, Barbara/0000-0002-2208-5370; Balsano, Clara/0000-0002-9615-7031 FU Fondo per gli Investimenti della Ricerca di Base [FIRB RBAP10MY35_002]; Ministero della Salute (IRE 5x1000) [RF-2011-02347907]; Fondazione Veronesi; Universita dell'Aquila FX The authors involved in this article have been supported by Fondo per gli Investimenti della Ricerca di Base (FIRB RBAP10MY35_002) (Andrea Galli), Ministero della Salute (IRE 5x1000; RF-2011-02347907) (Gabriele Toietta), Fondazione Veronesi (Roberta Maggio) and Universita dell'Aquila (Barbara Barbaro). 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J. Mol. Sci. PD OCT PY 2014 VL 15 IS 10 BP 18508 EP 18524 DI 10.3390/ijms151018508 PG 17 WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary WE Science Citation Index Expanded (SCI-EXPANDED) SC Biochemistry & Molecular Biology; Chemistry GA AS7TI UT WOS:000344457200052 PM 25318054 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Zelber-Sagi, S Noureddin, M Shibolet, O AF Zelber-Sagi, Shira Noureddin, Mazen Shibolet, Oren TI Lifestyle and Hepatocellular Carcinoma What Is the Evidence and Prevention Recommendations SO CANCERS LA English DT Review DE obesity; dietary composition; alcohol; smoking; physical activity ID CHRONIC LIVER-DISEASE; PHYSICAL-ACTIVITY; ALCOHOL-CONSUMPTION; CIGARETTE-SMOKING; REDUCES RISK; LIPID-PEROXIDATION; MEDITERRANEAN DIET; PNPLA3 RS738409; FATTY-ACIDS; CANCER AB Simple Summary The increasing public health burden of Hepatocellular carcinoma (HCC) emphasizes the importance of defining important modifiable risk factors. In the following review, we will discuss the evidence for the relation of major lifestyle risk factors, mostly from large population-based studies. Generally, it is has been shown that healthy lifestyle habits, including minimizing obesity, eating a healthy diet, avoidance of smoking and alcohol, and increasing physical activity, have the potential to prevent HCC. Dietary composition is important beyond obesity. Consumption of n-3 polyunsaturated fatty acids, as well as fish and poultry, vegetables and fiber, are inversely associated with HCC, while red meat, saturated fat, cholesterol and sugar are related to increased risk. Data from multiple studies clearly show a beneficial effect for physical activity in reducing the risk of HCC. Smoking and alcohol can lead to liver fibrosis and liver cancer and jointly lead to an even greater risk. The increasing burden of hepatocellular carcinoma (HCC) emphasizes the unmet need for primary prevention. Lifestyle measures appear to be important modifiable risk factors for HCC regardless of its etiology. Lifestyle patterns, as a whole and each component separately, are related to HCC risk. Dietary composition is important beyond obesity. Consumption of n-3 polyunsaturated fatty acids, as well as fish and poultry, are inversely associated with HCC, while red meat, saturated fat, and cholesterol are related to increased risk. Sugar consumption is associated with HCC risk, while fiber and vegetable intake is protective. Data from multiple studies clearly show a beneficial effect for physical activity in reducing the risk of HCC. However, the duration, mode and intensity of physical activity needed are yet to be determined. There is evidence that smoking can lead to liver fibrosis and liver cancer and has a synergistic effect with alcohol drinking. On the other hand, an excessive amount of alcohol by itself has been associated with increased risk of HCC directly (carcinogenic effect) or indirectly (liver fibrosis and cirrhosis progression. Large-scale intervention studies testing the effect of comprehensive lifestyle interventions on HCC prevention among diverse cohorts of liver disease patients are greatly warranted. C1 [Zelber-Sagi, Shira] Univ Haifa, Sch Publ Hlth, Fac Social Welf & Hlth Sci, IL-3498838 Haifa, Israel. [Zelber-Sagi, Shira; Shibolet, Oren] Tel Aviv Med Ctr & Sch Med, Dept Gastroenterol & Hepatol, IL-6423906 Tel Aviv, Israel. [Noureddin, Mazen] Cedars Sinai Med Ctr, Karsh Div Gastroenterol & Hepatol, Los Angeles, CA 90048 USA. [Shibolet, Oren] Tel Aviv Univ, Sackler Fac Med, IL-6697801 Tel Aviv, Israel. C3 University of Haifa; Tel Aviv University; Sackler Faculty of Medicine; Cedars Sinai Medical Center; Tel Aviv University; Sackler Faculty of Medicine RP Zelber-Sagi, S (通讯作者)，Univ Haifa, Sch Publ Hlth, Fac Social Welf & Hlth Sci, IL-3498838 Haifa, Israel.; Zelber-Sagi, S (通讯作者)，Tel Aviv Med Ctr & Sch Med, Dept Gastroenterol & Hepatol, IL-6423906 Tel Aviv, Israel. 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Dietary Epigenetic Modulators SO CURRENT PHARMACEUTICAL BIOTECHNOLOGY LA English DT Review DE Mediterranean diet; hyperlipidemia; plant extracts; vegetables; epigenetics; Randomized Controlled Trials (RCTs) ID CARDIOVASCULAR RISK-FACTORS; TYPE-2 DIABETIC-PATIENTS; LOW-DENSITY-LIPOPROTEIN; SERUM-LIPID PROFILE; FATTY LIVER-DISEASE; L. LEAF EXTRACT; DNA METHYLATION; ESSENTIAL OIL; METABOLIC SYNDROME; URSOLIC ACID AB Background: Cardiovascular Diseases (CVD) are, currently, the major contributor to global mortality and will continue to dominate mortality rates in the future. Hyperlipidemia refers to the elevated levels of lipids and cholesterol in the blood, and is also identified as dyslipidemia, manifesting in the form of different disorders of lipoprotein metabolism. These abnormalities may lead to the development of atherosclerosis, which can lead to coronary artery disease and stroke. In recent years, there is a growing interest in the quest for alternative therapeutic treatments based on natural products, offering better recovery and the avoidance of side effects. Recent technological advances have further improved our understanding of the role of epigenetic mechanisms in hyperlipidemic disorders and dietary prevention strategies. Objective: This is a comprehensive overview of the anti-hyperlipidemic effects of plant extracts, vegetables, fruits and isolated compounds thereof, with a focus on natural products from the Mediterranean region as well as the possible epigenetic changes in gene expression or cardiometabolic signaling pathways. Methods: For the purpose of this study, we searched the PubMed, Scopus and Google Scholar databases for eligible articles and publications over the last five years. The keywords included: "hyperlipidemia", "plant extract", "herbs", "natural products", "vegetables", 'cholesterol" and others. We initially included all relevant articles referring to in vitro studies, animal studies, Randomized Controlled Trials (RCTs) and previous reviews. Conclusion: Many natural products found in the Mediterranean diet have been studied for the treatment of hyperlipidemia. The antihyperlipidemic effect seems to he dose and/or consumption frequency related, which highlights the fact that a healthy diet can only be effective in reversing disease markers if it is consistent and within the framework of a healthy lifestyle. Finally, epigenetic biomarkers are increasingly recognized as new lifestyle management tools to monitor a healthy dietary lifestyle for the prevention of hyperlipidaemic disorders and comorbidities to promote a healthy life. C1 [Georgia-Eirini, Deligiannidou; Athina, Sygkouna; Christos, Kontogiorgis; Theodoros, Constantinides] Democritus Univ Thrace, Dept Med, Lab Hyg & Environm Protect, Campus Dragana Bldg 5, GR-68100 Alexandroupolis, Greece. [Wim, Vanden Berghe] Univ Antwerp, Dept Biomed Sci, Lab Prot Sci Prote & Epigenet Signaling PPES, B-2610 Antwerp, Belgium. C3 Democritus University of Thrace; University of Antwerp RP Christos, K (通讯作者)，Democritus Univ Thrace, Dept Med, Lab Hyg & Environm Protect, Campus Dragana Bldg 5, GR-68100 Alexandroupolis, Greece. 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Pharm. Biotechnol. PY 2019 VL 20 IS 10 BP 825 EP 844 DI 10.2174/1573407215666190628150921 PG 20 WC Biochemistry & Molecular Biology; Pharmacology & Pharmacy WE Science Citation Index Expanded (SCI-EXPANDED) SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy GA JB0WZ UT WOS:000488280400004 PM 31264546 DA 2026-02-02 ER PT J AU Abdollahi-Roodsaz, S Abramson, SB Scher, JU AF Abdollahi-Roodsaz, Shahla Abramson, Steven B. Scher, Jose U. TI The metabolic role of the gut microbiota in health and rheumatic disease: mechanisms and interventions SO NATURE REVIEWS RHEUMATOLOGY LA English DT Review ID INFLAMMATORY-BOWEL-DISEASE; CHAIN FATTY-ACIDS; INTESTINAL MICROBIOTA; PSORIATIC-ARTHRITIS; FISH-OIL; ALCOHOL-CONSUMPTION; ULCERATIVE-COLITIS; MEDITERRANEAN DIET; CONTROLLED-TRIAL; LIVER-DISEASE AB The role of the gut microbiome in animal models of inflammatory and autoimmune disease is now well established. The human gut microbiome is currently being studied as a potential modulator of the immune response in rheumatic disorders. However, the vastness and complexity of this host-microorganism interaction is likely to go well beyond taxonomic, correlative observations. In fact, most advances in the field relate to the functional and metabolic capabilities of these microorganisms and their influence on mucosal immunity and systemic inflammation. An intricate relationship between the microbiome and the diet of the host is now fully recognized, with the microbiota having an important role in the degradation of polysaccharides into active metabolites. This Review summarizes the current knowledge on the metabolic role of the microbiota in health and rheumatic disease, including the advances in pharmacomicrobiomics and its potential use in diagnostics, therapeutics and personalized medicine. C1 [Abdollahi-Roodsaz, Shahla; Abramson, Steven B.; Scher, Jose U.] NYU, Sch Med, Div Rheumatol, Dept Med, 301 East 17th St,Room 1608, New York, NY 10003 USA. [Abdollahi-Roodsaz, Shahla; Abramson, Steven B.; Scher, Jose U.] Hosp Joint Dis & Med Ctr, 301 East 17th St,Room 1608, New York, NY 10003 USA. [Abdollahi-Roodsaz, Shahla] Radboud Univ Nijmegen, Med Ctr, RIMLS, Geert Grootepl 28, NL-6525 GA Nijmegen, Netherlands. [Abdollahi-Roodsaz, Shahla] Radboud Univ Nijmegen, Med Ctr, Dept Rheumatol, Route 272,Geert Grootepl 28, NL-6525 GA Nijmegen, Netherlands. C3 New York University; NYU Langone Medical Center; Hospital for Joint Disease NYULMC; Radboud University Nijmegen; Radboud University Nijmegen RP Scher, JU (通讯作者)，NYU, Sch Med, Div Rheumatol, Dept Med, 301 East 17th St,Room 1608, New York, NY 10003 USA.; Scher, JU (通讯作者)，Hosp Joint Dis & Med Ctr, 301 East 17th St,Room 1608, New York, NY 10003 USA. EM jose.scher@nyumc.org RI ; Abdollahi-Roodsaz, Shahla/A-6620-2015 OI Abraon, Steven/0000-0002-0668-6344; FU Arthritis National Research Foundation [15-A0-00-004310-01]; Netherlands Organization for Scientific Research (VENI grant) [916.12.039]; Dutch Arthritis Foundation [AFS 14-1-291]; National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) through the American Recovery and Reinvestment Act [RC2 AR058986]; Colton Center for Autoimmunity; NIAMS [K23AR064318]; Arthritis Foundation (Innovative Research Grant); Riley Family Foundation FX S.A.-R. is supported by the Arthritis National Research Foundation (grant 15-A0-00-004310-01), the Netherlands Organization for Scientific Research (VENI grant 916.12.039) and the Dutch Arthritis Foundation (AFS 14-1-291 grant). S.B.A. is supported by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) through the American Recovery and Reinvestment Act of 2009 (grant RC2 AR058986) and by The Colton Center for Autoimmunity. J.U.S. is supported by NIAMS (grant K23AR064318), the Arthritis Foundation (Innovative Research Grant), The Colton Center for Autoimmunity; and The Riley Family Foundation. 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Oleanolic acid (OLA), a triterpene, has been reported to exert anti-obesity effects in animal models. Hence, we investigated the role of OLA in the modulation of oro-sensory perception of lipids in control and HFD-induced obese mice. As expected, OLA-treated obese mice exhibited a decrease in body, liver, and visceral adipose tissue weights. OLA treatment improved glucose tolerance, insulin level, plasma lipopolysaccharide (LPS), and hepatic cholesterol and triglyceride concentrations. OLA-treated obese mice exhibited higher fat preference compared to untreated obese mice, probably due to the increase in mRNA encoding CD36, a fat taste receptor, in mouse taste bud cells (mTBC). This phenomenon was associated with fatty-acid induced increases in free intracellular calcium concentrations, [Ca2+]i, induced in mTBC from OLA-treated obese mice. OLA also influenced the expression of mRNA encoding proinflammatory cytokines (IL-1 beta and IL-6) and some lipogenic genes (PPAR alpha, SREBP1, FAS, ChREBP, and G6Pase) in liver and adipose tissue. These findings reveal that OLA improves gustatory perception of lipids and exerts protective effects in obesity. (C) 2018 Elsevier B.V. and Societe Francaise de Biochimie et Biologie Moleculaire (SFBBM). All rights reserved. C1 [Djeziri, Fatima Zohra; Belarbi, Meriem; Benammar, Chahid] Univ Abou Bekr Belkaid Tlemcen, Lab Prod Nat, Tilimsen 13000, Algeria. [Murtaza, Babar; Hichami, Aziz; Khan, Naim Akhtar] UBFC, UMR INSERM U1231, Physiol Nutr & Toxicol, F-21000 Dijon, France. C3 Universite Abou Bekr Belkaid; Institut National de la Sante et de la Recherche Medicale (Inserm); Institut Agro; Institut Agro Dijon; Universite Bourgogne Europe RP Khan, NA (通讯作者)，UBFC, AgroSupDijon, UMR INSERM U1231, Physiol Nutr & Toxicol, 6 Blvd Gabriel, F-21000 Dijon, France. EM Naim.Khan@u-bourgogne.fr RI ; Murtaza, Babar/AAR-8200-2021; Hichami, Aziz/MCJ-2247-2025 OI Khan, Naim Akhtar/0000-0002-8930-9332; FU Inserm (France) [LABEX-LIPStick ANR-11-LABEX-002-01]; Algerian Ministry of Higher Education FX This work was supported by grants from Inserm (France) (LABEX-LIPStick ANR-11-LABEX-002-01). One of the authors (FZD) is highly thankful to Algerian Ministry of Higher Education that granted her an international scholarship to stay at NUTox team (INSERM UMR1231) under Programme National d'Excellence (PNE). 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We prospectively assessed the associations of three key commonly used a priori dietary patterns-the Alternative Healthy Eating Index-2010 (AHEI-2010), Alternate Mediterranean Diet (AMED), and Dietary Approaches to Stop Hypertension (DASH)-with risk of incident HCC in the Health Professionals Follow-Up Study (HPFS) and the Nurses' Health Study (NHS), two large prospective cohort studies. Diet was assessed almost every 4 years using validated food frequency questionnaires (FFQs). Multivariable hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated using Cox proportional hazards regression. During up to 32 years of follow-up, 160 incident HCC cases were identified. After adjustment for most HCC risk factors, participants in the highest tertile of Alternative Healthy Eating Index-2010 (AHEI-2010) had a multivariable HR of 0.61 (95% CI, 0.39-0.95; P-trend = 0.03), compared with those in the lowest tertile. There was a suggestive, but nonsignificant, inverse association for Alternate Mediterranean Diet (AMED; HR = 0.75; 95% CI, 0.49-1.15; P-trend = 0.18) and a null association for Dietary Approaches to Stop Hypertension (DASH; HR = 0.90; 95% CI, 0.59-1.36; P-trend = 0.61) in relation to the risk of HCC development. Conclusion: Our findings suggest that better adherence to the AHEI-2010 may decrease the risk of developing HCC among U.S. adults. Future studies are needed to replicate our results, examine these associations in other populations, and elucidate the underlying mechanisms. C1 [Ma, Yanan; Wen, Deliang] China Med Univ, Sch Publ Hlth, Shenyang, Liaoning, Peoples R China. [Ma, Yanan; Sui, Jing; Trang VoPham; Giovannucci, Edward L.; Chan, Andrew T.; Zhang, Xuehong] Brigham & Womens Hosp, Dept Med, Channing Div Network Med, 75 Francis St, Boston, MA 02115 USA. [Ma, Yanan; Sui, Jing; Trang VoPham; Meyerhardt, Jeffrey A.; Giovannucci, Edward L.; Chan, Andrew T.; Zhang, Xuehong] Harvard Med Sch, 181 Longwood Ave Room 453, Boston, MA 02115 USA. [Yang, Wanshui] Anhui Med Univ, Dept Nutr, Sch Publ Hlth, Hefei, Anhui, Peoples R China. [Simon, Tracey G.] Massachusetts Gen Hosp, Dept Med, Ctr Liver, Div Gastroenterol, Boston, MA 02114 USA. [Simon, Tracey G.; Chan, Andrew T.] Massachusetts Gen Hosp, Dept Med, Div Gastroenterol, Boston, MA 02114 USA. [Simon, Tracey G.; Chan, Andrew T.] Massachusetts Gen Hosp, CTEU, Boston, MA 02114 USA. [Smith-Warner, Stephanie A.; Fung, Teresa T.; Trang VoPham; Giovannucci, Edward L.] Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA. [Smith-Warner, Stephanie A.; Trang VoPham; Giovannucci, Edward L.] Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA. [Sui, Jing] Southeast Univ, Sch Publ Hlth, Minist Educ, Key Lab Environm Med Engn, Nanjing, Jiangsu, Peoples R China. [Chong, Dawn] Natl Canc Ctr Singapore, Singapore, Singapore. [Meyerhardt, Jeffrey A.] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA. C3 China Medical University; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard University; Harvard Medical School; Anhui Medical University; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard T.H. Chan School of Public Health; Harvard University; Harvard T.H. Chan School of Public Health; Southeast University - China; National Cancer Centre Singapore (NCCS); Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute RP Zhang, XH (通讯作者)，Harvard Med Sch, 181 Longwood Ave Room 453, Boston, MA 02115 USA.; Zhang, XH (通讯作者)，Brigham & Womens Hosp, 181 Longwood Ave Room 453, Boston, MA 02115 USA. EM xuehong.zhang@channing.harvard.edu RI VoPham, Trang/AFJ-8930-2022; Yang, Wanshui/S-9322-2019; Meyerhardt, Jeffrey/IAP-4528-2023; Zhang, Xuehong/E-6219-2012; ma, Yanan/NNG-1429-2025; Chan, Andrew/ADM-9271-2022; Giovannucci, Edward/ADE-8028-2022 OI VoPham, Trang/0000-0003-4787-1201; Yang, Wanshui/0000-0002-7365-2689; FU National Cancer Institute [T32CA009001, UM1CA186107] Funding Source: NIH RePORTER; National Institute of Diabetes and Digestive and Kidney Diseases [P30DK046200] Funding Source: NIH RePORTER; NCI NIH HHS [K07 CA188126, T32 CA009001, UM1 CA167552, R03 CA176717, P01 CA087969, UM1 CA186107] Funding Source: Medline; NIDDK NIH HHS [K24 DK098311, P30 DK046200] Funding Source: Medline CR Adachi Y, 2016, TUMOR BIOL, V37, P15125, DOI 10.1007/s13277-016-5360-z AlEssa HB, 2017, AM J CLIN NUTR, V105, P432, DOI 10.3945/ajcn.116.143016 Andrighetto LV, 2016, ABCD-ARQ BRAS CIR DI, V29, P276, DOI 10.1590/0102-6720201600040015 Bray F, 2013, INT J CANCER, V132, P1133, DOI 10.1002/ijc.27711 Chiuve SE, 2012, J NUTR, V142, P1009, DOI 10.3945/jn.111.157222 COLDITZ GA, 1986, AM J EPIDEMIOL, V123, P894, DOI 10.1093/oxfordjournals.aje.a114319 COX DR, 1972, J R STAT SOC B, V34, P187 Dietrich P, 2014, BEST PRACT RES CL GA, V28, P637, DOI 10.1016/j.bpg.2014.07.008 Freedman ND, 2010, J NATL CANCER I, V102, P1354, DOI 10.1093/jnci/djq301 Fung TT, 2008, ARCH INTERN MED, V168, P713, DOI 10.1001/archinte.168.7.713 Fung TT, 2018, J ACAD NUTR DIET, V118, P2269, DOI 10.1016/j.jand.2017.11.022 Fung TT, 2009, CIRCULATION, V119, P1093, DOI 10.1161/CIRCULATIONAHA.108.816736 Fung TT, 2005, AM J CLIN NUTR, V82, P163 Hoppe C, 2004, EUR J CLIN NUTR, V58, P1211, DOI 10.1038/sj.ejcn.1601948 Hu FB, 1999, AM J CLIN NUTR, V69, P243 Huth PJ, 2012, ADV NUTR, V3, P266, DOI 10.3945/an.112.002030 Jemal A, 2017, JNCI-J NATL CANCER I, V109, DOI 10.1093/jnci/djx030 KENNEDY ET, 1995, J AM DIET ASSOC, V95, P1103, DOI 10.1016/S0002-8223(95)00300-2 Koh WP, 2016, LIVER INT, V36, P893, DOI 10.1111/liv.12978 Koumbi L, 2017, WORLD J HEPATOL, V9, P119, DOI 10.4254/wjh.v9.i3.119 Kuper H, 2000, NUTR CANCER, V38, P6, DOI 10.1207/S15327914NC381_2 Kurozawa Youichi, 2004, Kurume Medical Journal, V51, P141, DOI 10.2739/kurumemedj.51.141 Li WQ, 2014, HEPATOLOGY, V60, P588, DOI 10.1002/hep.27160 Lukanova A, 2014, INT J CANCER, V134, P164, DOI 10.1002/ijc.28342 Ma J, 2001, J NATL CANCER I, V93, P1330, DOI 10.1093/jnci/93.17.1330 Ma Y, 2016, BIOCHEM BIOPH RES CO, V478, P964, DOI 10.1016/j.bbrc.2016.08.059 Malaguarnera R, 2014, FRONT ENDOCRINOL, V5, DOI 10.3389/fendo.2014.00010 McCullough ML, 2002, AM J CLIN NUTR, V76, P1261, DOI 10.1093/ajcn/76.6.1261 McEvoy CT, 2014, J ACAD NUTR DIET, V114, P1759, DOI 10.1016/j.jand.2014.05.001 Mirmiran P, 2017, IRAN J PUBLIC HEALTH, V46, P1007 Mu M, 2017, IRAN J PUBLIC HEALTH, V46, P869 Nakagawa H, 2009, INT J CANCER, V125, P2264, DOI 10.1002/ijc.24720 National Cancer Institute, 2018, APPL RES CANC CONTR Nguyen HA, 2002, AM J GASTROENTEROL, V97, P1813, DOI 10.1111/j.1572-0241.2002.05800.x Ohishi W, 2014, INT J CANCER, V134, P154, DOI 10.1002/ijc.28337 Petrick JL, 2018, BRIT J CANCER, V118, P1005, DOI 10.1038/s41416-018-0007-z Rezagholizadeh F, 2017, NUTR RES, V41, P1, DOI 10.1016/j.nutres.2017.01.006 RIMM EB, 1992, AM J EPIDEMIOL, V135, P1114, DOI 10.1093/oxfordjournals.aje.a116211 Ryerson AB, 2016, CANCER-AM CANCER SOC, V122, P1312, DOI 10.1002/cncr.29936 SALVINI S, 1989, INT J EPIDEMIOL, V18, P858, DOI 10.1093/ije/18.4.858 Sawada N, 2012, GASTROENTEROLOGY, V142, P1468, DOI 10.1053/j.gastro.2012.02.018 Tapsell LC, 2016, ADV NUTR, V7, P445, DOI 10.3945/an.115.011718 Tasevska N, 2012, INT J CANCER, V130, P159, DOI 10.1002/ijc.25990 Trichopoulou A, 2003, NEW ENGL J MED, V348, P2599, DOI 10.1056/NEJMoa025039 Vogtmann E, 2013, ANN ONCOL, V24, P238, DOI 10.1093/annonc/mds287 Welzel TM, 2013, AM J GASTROENTEROL, V108, P1314, DOI 10.1038/ajg.2013.160 Zhang W, 2013, CANCER SCI, V104, P1353, DOI 10.1111/cas.12231 NR 47 TC 81 Z9 85 U1 2 U2 34 PU WILEY PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0270-9139 EI 1527-3350 J9 HEPATOLOGY JI Hepatology PD AUG PY 2019 VL 70 IS 2 BP 577 EP 586 DI 10.1002/hep.30362 PG 10 WC Gastroenterology & Hepatology WE Science Citation Index Expanded (SCI-EXPANDED) SC Gastroenterology & Hepatology GA IN4HO UT WOS:000478636000012 PM 30506561 OA Green Submitted DA 2026-02-02 ER PT J AU Cianciosi, D Diaz, YA Grosso, G Quiles, JL Giampieri, F Battino, M AF Cianciosi, Danila Diaz, Yasmany Armas Grosso, Giuseppe Quiles, Jose L. Giampieri, Francesca Battino, Maurizio TI Association between diagnostic imaging and biochemical markers: a possible tool for monitoring metabolic disorders SO CURRENT OPINION IN FOOD SCIENCE LA English DT Article ID FATTY LIVER-DISEASE; MEDITERRANEAN DIET; ADIPOSE-TISSUE; OBESITY; RISK; CONSEQUENCES; CHOLESTEROL; MECHANISMS; ADULTS; INDEX AB Metabolic syndrome (MetS), obesity, and diabetes mellitus (DM) are the most common metabolic disorders (MDs) in the world, characterized by abnormalities in body's metabolic processes. The typical diagnosis of MDs is usually executed by monitoring the levels of specific biochemical markers, but diagnostic imaging may provide valuable complementary information in MDs, offering advantages in diagnosis, target organ monitoring, follow-up, and development of new therapeutic approaches. The aim of this review is to summarize and discuss the studies published in the literature about the connection between images deriving from the diagnostic techniques and the key biochemical markers in the main MDs, in order to gain a comprehensive view of the different disorders. C1 [Cianciosi, Danila; Diaz, Yasmany Armas; Giampieri, Francesca; Battino, Maurizio] Univ Politecn Marche, Dipartimento Sci Clin Specialist Odontostomatolog, Via Ranieri 65, I-60130 Ancona, Italy. [Grosso, Giuseppe] Univ Catania, Dept Biomed & Biotechnol Sci, Catania, Italy. [Quiles, Jose L.] Univ Granada, Inst Nutr & Food Technol Jose Mataix, Biomed Res Ctr, Dept Physiol, Avda Conocimiento S-N,Parque Tecnol Salud, Armilla 18016, Granada, Spain. [Quiles, Jose L.; Giampieri, Francesca; Battino, Maurizio] Univ Europea Atlant, Res Grp Foods Nutr Biochem & Hlth, Isabel Torres 21, Santander 39011, Spain. [Quiles, Jose L.] Res & Dev Funct Food Ctr CIDAF, Hlth Sci Technol Pk,Ave Conocimiento 37, Granada 18016, Spain. [Battino, Maurizio] Jiangsu Univ, Int Joint Res Lab Intelligent Agr & Agriprod Proc, Zhenjiang 212013, Peoples R China. C3 Marche Polytechnic University; University of Catania; University of Granada; Jiangsu University RP Giampieri, F; Battino, M (通讯作者)，Univ Politecn Marche, Dipartimento Sci Clin Specialist Odontostomatolog, Via Ranieri 65, I-60130 Ancona, Italy.; Giampieri, F; Battino, M (通讯作者)，Univ Europea Atlant, Res Grp Foods Nutr Biochem & Hlth, Isabel Torres 21, Santander 39011, Spain.; Battino, M (通讯作者)，Jiangsu Univ, Int Joint Res Lab Intelligent Agr & Agriprod Proc, Zhenjiang 212013, Peoples R China. 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Opin. Food Sci. PD FEB PY 2024 VL 55 AR 101109 DI 10.1016/j.cofs.2023.101109 EA DEC 2023 PG 10 WC Food Science & Technology WE Science Citation Index Expanded (SCI-EXPANDED) SC Food Science & Technology GA EO4F9 UT WOS:001139848000001 OA Green Submitted, hybrid DA 2026-02-02 ER PT J AU Luu, HN Neelakantan, N Geng, TT Wang, RW Goh, GBB Clemente, JC Jin, AZ van Dam, RM Jia, W Behari, J Koh, WP Yuan, JM AF Luu, Hung N. Neelakantan, Nithya Geng, Ting-ting Wang, Renwei Goh, George Boon-Bee Clemente, Jose C. Jin, Aizhen van Dam, Rob M. Jia, Wei Behari, Jaideep Koh, Woon-Puay Yuan, Jian-Min TI Quality diet indexes and risk of hepatocellular carcinoma: Findings from the Singapore Chinese Health Study SO INTERNATIONAL JOURNAL OF CANCER LA English DT Article DE diet‐ quality index (DQI) scores; hepatocellular carcinoma; risk factor ID POLYUNSATURATED FATTY-ACIDS; POPULATION-BASED SAMPLE; CHRONIC LIVER-DISEASE; OLDER CHINESE; CARDIOVASCULAR-DISEASE; MEDITERRANEAN DIET; REDUCED RISK; MORTALITY; CANCER; ADHERENCE AB There is limited research on the effect of dietary quality on hepatocellular carcinoma (HCC) risk in populations with relatively high risk of HCC. Using data from Singapore Chinese Health Study, a prospective cohort study, of 63 257 Chinese aged 45 to 74, we assessed four diet-quality index (DQI) scores: the Alternative Health Eating Index-2010 (AHEI-2010), Alternate Mediterranean Diet (aMED), Dietary Approaches to Stop Hypertension (DASH) and Heathy Diet Indicator (HDI). We identified 561 incident HCC cases among the cohort participants after a mean of 17.6 years of follow-up. Cox proportional hazard regression model was used to estimate hazard ratio (HR) and 95% confidence interval (CI) for HCC in relation to these DQI scores. Unconditional logistic regression method was used to evaluate the associations between DQIs and HCC risk among a subset of individuals who tested negative for hepatitis B surface antigen (HBsAg). High scores of AHEI-2010, aMED and DASH, representing higher dietary quality, were associated with lower risk of HCC (all P-trend < .05). Compared with the lowest quartile, HRs (95% CIs) of HCC for the highest quartile of AHEI-2010, aMED and DASH were 0.69 (0.53-0.89), 0.70 (0.52-0.95) and 0.67 (0.51-0.87), respectively. No significant association between HDI and HCC risk was observed. Among HBsAg-negative individuals, similar inverse associations were observed, and the strongest inverse association was for aMED (HRQ4vsQ1 = 0.46, 95% CI: 0.23-0.94, P-trend = .10). These findings support the notion that adherence to a healthier diet may lower the risk of HCC, suggesting that dietary modification may be an effective approach for primary prevention of HCC. C1 [Luu, Hung N.; Wang, Renwei; Yuan, Jian-Min] Univ Pittsburgh, UPMC Hillman Canc Ctr, Div Canc Control & Populat Sci, UPMC Canc Pavil,Suite 4C,Room 466,5150 Ctr Ave, Pittsburgh, PA 15232 USA. [Luu, Hung N.; Yuan, Jian-Min] Univ Pittsburgh, Grad Sch Publ Hlth, Dept Epidemiol, Pittsburgh, PA 15232 USA. [Neelakantan, Nithya; Geng, Ting-ting; van Dam, Rob M.; Koh, Woon-Puay] Natl Univ Singapore, Saw Swee Hock Sch Publ Hlth, Singapore, Singapore. [Goh, George Boon-Bee; Jin, Aizhen; Koh, Woon-Puay] Duke NUS Med Sch, Hlth Serv & Syst Res, Singapore, Singapore. [Goh, George Boon-Bee] Singapore Gen Hosp, Dept Gastroenterol & Hepatol, Singapore, Singapore. [Clemente, Jose C.] Icahn Sch Med Mt Sinai, Dept Genet & Genom Sci, Icahn Inst Genom & Multiscale Biol, New York, NY 10029 USA. [van Dam, Rob M.] Natl Univ Singapore, Yong Loo Lin Sch Med, Singapore, Singapore. [van Dam, Rob M.] Natl Univ Hlth Syst, Singapore, Singapore. [van Dam, Rob M.] Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA. [Jia, Wei] Univ Hawaii, Canc Ctr, Honolulu, HI 96822 USA. [Behari, Jaideep] Univ Pittsburgh, Dept Med, Div Gastroenterol Hepatol & Nutr, Med Ctr, Pittsburgh, PA 15232 USA. [Behari, Jaideep] Univ Pittsburgh, Pittsburgh Liver Res Ctr, Med Ctr, Pittsburgh, PA 15232 USA. C3 Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; National University of Singapore; National University of Singapore; Singapore General Hospital; Icahn School of Medicine at Mount Sinai; National University of Singapore; National University of Singapore; Harvard University; Harvard T.H. Chan School of Public Health; University of Hawaii System; Cancer Research Center of Hawaii; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh RP Luu, HN (通讯作者)，Univ Pittsburgh, UPMC Hillman Canc Ctr, Div Canc Control & Populat Sci, UPMC Canc Pavil,Suite 4C,Room 466,5150 Ctr Ave, Pittsburgh, PA 15232 USA. EM luuh@upmc.edu RI Jia, Wei/NGR-8016-2025; NEELAKANTAN, NITHYA/AAJ-5167-2021; van Dam, Rob/F-9674-2010; Luu, Hung/AFP-5765-2022; Clemente, Jose/T-2561-2018; Goh, George/AFK-5930-2022 OI Jia, Wei/0000-0002-3739-8994; NEELAKANTAN, NITHYA/0000-0002-2128-6322; Luu, Hung/0000-0002-2172-1849; Geng, Ting-Ting/0000-0002-6220-3968 FU University of Pittsburgh Medical Center Hillman Cancer Center; National Institutes of Health [UM1 CA182876, R01 CA144034] FX University of Pittsburgh Medical Center Hillman Cancer Center; National Institutes of Health, Grant/Award Numbers: UM1 CA182876, R01 CA144034 CR Adachi Y, 2016, TUMOR BIOL, V37, P15125, DOI 10.1007/s13277-016-5360-z American Cancer Society, 2020, CANC FACTS FIGURES 2 Appel LJ, 1997, NEW ENGL J MED, V336, P1117, DOI 10.1056/NEJM199704173361601 Bogumil D, 2019, HEPATOL COMMUN, V3, P437, DOI 10.1002/hep4.1313 Burt AD, 2015, SEMIN LIVER DIS, V35, P207, DOI 10.1055/s-0035-1562942 Butler LM, 2010, AM J CLIN NUTR, V91, P1013, DOI 10.3945/ajcn.2009.28572 Calder PC, 2006, PROSTAG LEUKOTR ESS, V75, P197, DOI 10.1016/j.plefa.2006.05.012 Calder PC, 2013, BRIT J CLIN PHARMACO, V75, P645, DOI 10.1111/j.1365-2125.2012.04374.x Chiuve SE, 2012, J NUTR, V142, P1009, DOI 10.3945/jn.111.157222 Eaglehouse YL, 2017, EUR J CANCER PREV, V26, P469, DOI 10.1097/CEJ.0000000000000369 *EASLEASDEASO, 2016, J HEPATOL, V64, P1388 El-Serag HB, 2007, GASTROENTEROLOGY, V132, P2557, DOI 10.1053/j.gastro.2007.04.061 Freedman LS, 2011, J NATL CANCER I, V103, P1086, DOI 10.1093/jnci/djr189 Fung TT, 2008, ARCH INTERN MED, V168, P713, DOI 10.1001/archinte.168.7.713 Fung TT, 2006, J NUTR, V136, P466, DOI 10.1093/jn/136.2.466 Godos J, 2017, INT J FOOD SCI NUTR, V68, P18, DOI 10.1080/09637486.2016.1214239 Hankin JH, 2001, NUTR CANCER, V39, P187, DOI 10.1207/S15327914nc392_5 Hashimoto E, 2012, HEPATOL RES, V42, P1, DOI 10.1111/j.1872-034X.2011.00872.x Health Promotion Board, 2010, MY HLTH PLAT FACT SH Huijbregts P, 1997, BRIT MED J, V315, P13, DOI 10.1136/bmj.315.7099.13 Jankovic N, 2015, AM J CLIN NUTR, V102, P745, DOI 10.3945/ajcn.114.095117 Koh WP, 2011, BRIT J CANCER, V105, P1430, DOI 10.1038/bjc.2011.360 Koh WP, 2005, J NUTR, V135, P2473, DOI 10.1093/jn/135.10.2473 Koh WP, 2016, LIVER INT, V36, P893, DOI 10.1111/liv.12978 Kurotani K, 2016, BMJ-BRIT MED J, V352, DOI 10.1136/bmj.i1209 Li WQ, 2014, HEPATOLOGY, V60, P588, DOI 10.1002/hep.27160 Liese AD, 2015, J NUTR, V145, P393, DOI 10.3945/jn.114.205336 Ma YN, 2019, HEPATOLOGY, V70, P577, DOI 10.1002/hep.30362 McCullough ML, 2002, AM J CLIN NUTR, V76, P1261, DOI 10.1093/ajcn/76.6.1261 Mirmiran P, 2017, IRAN J PUBLIC HEALTH, V46, P1007 Monteiro J, 2014, FOOD FUNCT, V5, P426, DOI 10.1039/c3fo60551e Nakagawa H, 2009, INT J CANCER, V125, P2264, DOI 10.1002/ijc.24720 Neelakantan N, 2018, J NUTR, V148, P1323, DOI 10.1093/jn/nxy094 Neelakantan N, 2016, J NUTR, V146, P1379, DOI 10.3945/jn.116.231605 Noone A, 2018, SEER CANC STAT REV 1 Ohishi W, 2014, INT J CANCER, V134, P154, DOI 10.1002/ijc.28337 Page JM, 2009, CLIN LIVER DIS, V13, P631, DOI 10.1016/j.cld.2009.07.007 Parkin DM, 2002, CANC INCIDENCE 5 CON, VVIII, P781 Perdomo CM, 2019, NUTRIENTS, V11, DOI 10.3390/nu11030677 Ross AB, 2013, INT J ENDOCRINOL, V2013, DOI 10.1155/2013/585876 Seow A, 1998, CANCER EPIDEM BIOMAR, V7, P135 Seow A, 1998, CANCER EPIDEM BIOMAR, V7, P775 Sung H, 2021, CA-CANCER J CLIN, V71, P209, DOI 10.3322/caac.21660 Tapsell LC, 2016, ADV NUTR, V7, P445, DOI 10.3945/an.115.011718 The Whole Grains Council, 2017, OLDW WHOL GRAINS COU TRICHOPOULOU A, 1995, BMJ-BRIT MED J, V311, P1457, DOI 10.1136/bmj.311.7018.1457 Trichopoulou A, 2003, NEW ENGL J MED, V348, P2599, DOI 10.1056/NEJMoa025039 Trombetta A, 2007, CHEM-BIOL INTERACT, V165, P239, DOI 10.1016/j.cbi.2006.12.014 Turati F, 2014, J HEPATOL, V60, P606, DOI 10.1016/j.jhep.2013.10.034 World Health Organization (WHO), 1990, WHO TECHN REP SER Yu DX, 2014, AM J CLIN NUTR, V100, P693, DOI 10.3945/ajcn.113.079194 Yuan JM, 2003, CANCER EPIDEM BIOMAR, V12, P890 Zhang W, 2013, CANCER SCI, V104, P1353, DOI 10.1111/cas.12231 NR 53 TC 23 Z9 22 U1 0 U2 9 PU WILEY PI HOBOKEN PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA SN 0020-7136 EI 1097-0215 J9 INT J CANCER JI Int. J. Cancer PD MAY 1 PY 2021 VL 148 IS 9 BP 2102 EP 2114 DI 10.1002/ijc.33367 EA NOV 2020 PG 13 WC Oncology WE Science Citation Index Expanded (SCI-EXPANDED) SC Oncology GA QX4MA UT WOS:000586083400001 PM 33129230 OA Green Submitted, Bronze DA 2026-02-02 ER PT J AU Hu, XF Zhang, R Chan, HM AF Hu, Xue Feng Zhang, Rui Chan, Hing Man TI Identification of Chinese dietary patterns and their relationships with health outcomes: a systematic review and meta-analysis SO PUBLIC HEALTH NUTRITION LA English DT Review DE Chinese diets; Dietary pattern; CVD; Cancer; Metabolic syndrome; Systematic review and meta-analysis ID GESTATIONAL DIABETES-MELLITUS; IMPAIRED FASTING GLUCOSE; LARGE PROSPECTIVE COHORT; DWELLING OLDER-PEOPLE; FATTY LIVER-DISEASE; LIFE-STYLE FACTORS; MEDITERRANEAN DIET; NUTRITION TRANSITION; METABOLIC SYNDROME; ELDERLY CHINESE AB Objective: China has been undergoing a rapid nutrition transition in the past few decades. This review aims to characterise commonly reported dietary patterns in Chinese populations and their associations with health outcomes.Design: We searched PubMed, Embase and CNKI from inception to June 2020 to identify observational studies reporting dietary patterns or the associations between dietary patterns and health outcomes. Information regarding dietary patterns, their association with health outcomes and other related items was collected.Setting: Chinese population and Chinese immigrants.Participants: Not applicable.Results: Results from 130 studies with over 900 000 participants were included. Six dietary patterns were identified: traditional whole-grain diet (Traditional WG), traditional non-whole-grain diet (Traditional NWG), plant-based diet (Plant-based), animal food diet (Animal-food), Western energy-dense diet (Western) and other unclassified diets (Unclassified). The Plant-based diet was associated with a reduced risk of CVD and cancer from prospective studies, reduced risk of diabetes, hypertension, cognitive impairment and depressive symptoms from all study designs. The Traditional WG diet was associated with a reduced risk of diabetes and hypertension. Animal-food diet is associated with a range of metabolic diseases, and Western diet was associated with increased risks of obesity and depressive symptoms.Conclusion: Multiple dietary patterns identified reflect the diversity and transitioning of the Chinese diet. A healthy Chinese diet, comprising both the Traditional WG and Plant-based diets, was associated with reduced risks of specific undesirable health outcomes. Promoting this healthy diet will improve public health among the Chinese populations. C1 [Hu, Xue Feng; Zhang, Rui; Chan, Hing Man] Univ Ottawa, Dept Biol, Chem & Environm Toxicol Program, Ottawa, ON K1N 6N5, Canada. C3 University of Ottawa RP Chan, HM (通讯作者)，Univ Ottawa, Dept Biol, Chem & Environm Toxicol Program, Ottawa, ON K1N 6N5, Canada. EM laurie.chan@uottawa.ca RI ; Chan, Laurie/C-4055-2014 OI Hu, Xuefeng/0000-0001-6794-5699; Chan, Laurie/0000-0003-4351-7483; Zhang, Rui/0000-0003-3496-4070 FU Canada Research Chair Program (CRC) FX H.M.C. received findings from the Canada Research ChairProgram (CRC). 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PD OCT 14 PY 2024 VL 27 IS 1 AR e209 DI 10.1017/S1368980024001927 PG 15 WC Public, Environmental & Occupational Health; Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Public, Environmental & Occupational Health; Nutrition & Dietetics GA I7U0F UT WOS:001332258400001 PM 39397510 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Yago, MD Díaz, RJ Martínez, MA Audi, N Naranjo, JA Martínez-Victoria, E Mañas, M AF Yago, MD Díaz, RJ Martínez, MA Audi, N Naranjo, JA Martínez-Victoria, E Mañas, M TI Effects of the type of dietary fat on acetylcholine-evoked amylase secretion and calcium mobilization in isolated rat pancreatic acinar cells SO JOURNAL OF NUTRITIONAL BIOCHEMISTRY LA English DT Article DE dietary fat; olive oil; pancreatic acinar cells; membrane fatty acids; cell calcium; rat ID MEMBRANE-LIPID-COMPOSITION; VIRGIN OLIVE OIL; GUINEA-PIG; MUSCARINIC RECEPTORS; ACID COMPOSITION; SUNFLOWER OIL; CHOLECYSTOKININ; HEART; LIVER; ANTIOXIDANT AB Olive oil is a major component of the Mediterranean diet, and its role in human health is being actively debated. This study aimed to clarify the mechanism of pancreatic adaptation to dietary fat. For this purpose, we examined whether dietary-induced modification of pancreatic membranes affects acinar cell function in response to the secretagogue acetylcholine (ACh). Weaning male Wistar rats were assigned to one of two experimental groups and fed for 8 weeks with a commercial chow (C) or a semisynthetic diet containing virgin olive oil as dietary fat (OO). The fatty acid composition of pancreatic plasma membranes was determined by gas-liquid chromatography. For assessment of secretory function, viable acini were incubated with ACh and amylase of supernatant was further assayed with a substrate reagent. Changes in cytosolic Ca2+ concentration in response to ACh were measured by fura-2 AM fluorimetry. Compared to C rats, pancreatic cell membranes of OO rats had a higher level of monounsaturated fatty acids and a lower level of both saturated and polyunsaturated fatty acids, thus, reflecting the type of dietary fat given. Net amylase secretion in response to ACh was greatly enhanced after OO feeding, although this was not paralleled by enhancement of ACh-evoked Ca2+ peak increases. In conclusion, chronic intake of diets that differ in the fat type influences not only the fatty acid composition of rat pancreatic membranes but also the responsiveness of acinar cells to ACh. This mechanism may be, at least in part, responsible for the adaptation of the exocrine pancreas to the type of fat available. (c) 2006 Elsevier Inc. All rights reserved. C1 Univ Granada, Dept Fisiol, Inst Nutr & Tecnol Alimentos, E-18071 Granada, Spain. Univ Granada, Fac Ciencias Educ, Dept Didact Ciencias Expt, E-18071 Granada, Spain. C3 University of Granada; University of Granada RP Yago, MD (通讯作者)，Univ Granada, Dept Fisiol, Inst Nutr & Tecnol Alimentos, C-Ramon & Cajal 4, E-18071 Granada, Spain. 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Nutr. Biochem. PD APR PY 2006 VL 17 IS 4 BP 242 EP 249 DI 10.1016/j.jnutbio.2005.04.009 PG 8 WC Biochemistry & Molecular Biology; Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Biochemistry & Molecular Biology; Nutrition & Dietetics GA 028YR UT WOS:000236525200004 PM 16099640 DA 2026-02-02 ER PT J AU Ronen, D Rokach, Y Abedat, S Qadan, A Daana, S Amir, O Asleh, R AF Ronen, Daniel Rokach, Yair Abedat, Suzan Qadan, Abed Daana, Samar Amir, Offer Asleh, Rabea TI Human Gut Microbiota in Cardiovascular Disease SO COMPREHENSIVE PHYSIOLOGY LA English DT Article ID TRIMETHYLAMINE-N-OXIDE; FATTY LIVER-DISEASE; CORONARY-HEART-DISEASE; FARNESOID-X-RECEPTOR; INTESTINAL BARRIER FUNCTION; FECAL MICROBIOTA; INDOXYL SULFATE; MYOCARDIAL-INFARCTION; ARTERY-DISEASE; ATRIAL-FIBRILLATION AB The gut ecosystem, termed microbiota, is composed of bacteria, archaea, viruses, protozoa, and fungi and is estimated to outnumber human cells. Microbiota can affect the host by multiple mechanisms, including the synthesis of metabolites and toxins, modulating inflammation and interaction with other organisms. Advances in understanding commensal organisms' effect on human conditions have also elucidated the importance of this community for cardiovascular disease (CVD). This effect is driven by both direct CV effects and conditions known to increase CV risk, such as obesity, diabetes mellitus (DM), hypertension, and renal and liver diseases. Cardioactive metabobile acids, and uremic toxins, can affect atherosclerosis, platelet activation, and inflammation, resulting in increased CV incidence. Interestingly, this interaction is bidirectional with microbiota affected by multiple host conditions including diet, bile acid secretion, and multiple diseases affecting the gut barrier. This interdependence makes manipulating microbiota an attractive option to reduce CV risk. Indeed, evolving data suggest that the benefits observed from low red meat and Mediterranean diet consumption can be explained, at least partially, by the changes that these diets may have on the gut microbiota. In this article, we depict the current epidemiological and mechanistic understanding of the role of microbiota and CVD. Finally, we discuss the potential therapeutic approaches aimed at manipulating gut microbiota to improve CV outcomes. C1 [Ronen, Daniel; Rokach, Yair; Abedat, Suzan; Qadan, Abed; Daana, Samar; Amir, Offer; Asleh, Rabea] Hebrew Univ Jerusalem, Cardiovasc Res Ctr, Heart Inst, Hadassah Med Ctr,Fac Med, Jerusalem, Israel. C3 Hebrew University of Jerusalem; Hadassah University Hospital; Hadassah University Medical Center RP Asleh, R (通讯作者)，Hebrew Univ Jerusalem, Cardiovasc Res Ctr, Heart Inst, Hadassah Med Ctr,Fac Med, Jerusalem, Israel. 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615 TC 9 Z9 10 U1 3 U2 18 PU WILEY PI HOBOKEN PA 111 RIVER ST, HOBOKEN, NJ 07030 USA SN 2040-4603 J9 COMPR PHYSIOL JI Compr. Physiol. PD JUL PY 2024 VL 14 IS 3 BP 5449 EP 5490 DI 10.1002/cphy.c230012 PG 42 WC Physiology WE Science Citation Index Expanded (SCI-EXPANDED) SC Physiology GA H7M1T UT WOS:001325237300001 PM 39109979 DA 2026-02-02 ER PT J AU Zhao, CC Wu, XY Yi, H Chen, R Fan, G AF Zhao, Cheng-Cheng Wu, Xin-Yue Yi, Huan Chen, Rong Fan, Gang TI The Therapeutic Effects and Mechanisms of Salidroside on Cardiovascular and Metabolic Diseases: An Updated Review SO CHEMISTRY & BIODIVERSITY LA English DT Review DE salidroside; metabolic disease; diabetes; cardiovascular disease; atherosclerosis ID ISCHEMIA-REPERFUSION INJURY; TYPE-2 DIABETES-MELLITUS; FATTY LIVER-DISEASE; OLIVE OIL; LIPID-METABOLISM; MEDITERRANEAN DIET; RHODIOLA-CRENULATA; PHENOLIC-COMPOUNDS; ENDOTHELIAL-CELLS; OXIDATIVE STRESS AB The increasing incidence of metabolic and cardiovascular diseases has severely affected global human health and life safety. In recent years, some effective drugs with remarkable curative effects and few side effects found in natural compounds have attracted attention. Salidroside (SAL), a phenylpropane glycoside, is the main active ingredient of the plateau plant Rhodiola. So far, many animal experiments proved that SAL has good biological activity against some metabolic and cardiovascular diseases. However, most of these reports are scattered. This review systematically summarizes the pharmacological progress of SAL in the treatment of several metabolic (e. g., diabetes and non-alcoholic fatty liver disease) and cardiovascular (e. g., atherosclerosis) diseases in a timely manner to promote the clinical application and basic research of SAL. Accumulating evidence proves that SAL has beneficial effects on these diseases. It can improve glucose tolerance, insulin sensitivity, and beta-cell and liver functions, and inhibit adipogenesis, inflammation and oxidative stress. Overall, SAL may be a valuable and potential drug candidate for the treatment of metabolic and cardiovascular diseases. However, more studies especially clinical trials are needed to further confirm its therapeutic effects and molecular mechanisms. C1 [Zhao, Cheng-Cheng; Wu, Xin-Yue; Yi, Huan] Chengdu Univ Tradit Chinese Med, Sch Pharm, Chengdu 611137, Peoples R China. [Chen, Rong; Fan, Gang] Chengdu Univ Tradit Chinese Med, Sch Ethn Med, Chengdu 611137, Peoples R China. C3 Chengdu University of Traditional Chinese Medicine; Chengdu University of Traditional Chinese Medicine RP Chen, R; Fan, G (通讯作者)，Chengdu Univ Tradit Chinese Med, Sch Ethn Med, Chengdu 611137, Peoples R China. EM chenrong@cdutcm.edu.cn; fangang1111@163.com RI Fan, Gang/AGG-2500-2022 OI Fan, Gang/0000-0002-3023-9472 FU National Key Research and Development Program of China [2019YFC1712302]; Xinglin Scholar Research Promotion Project of Chengdu University of TCM [XSGG2018013, QNXZ2018043] FX The authors gratefully acknowledge the financial support from the National Key Research and Development Program of China (No. 2019YFC1712302) and the Xinglin Scholar Research Promotion Project of Chengdu University of TCM (Nos. XSGG2018013 and QNXZ2018043). CR Adams LA, 2017, GUT, V66, P1138, DOI 10.1136/gutjnl-2017-313884 Alameddine A, 2015, J PHYSIOL PHARMACOL, V66, P249 [Anonymous], 2012, Int. Res. J. 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Biodivers. PD JUL PY 2021 VL 18 IS 7 DI 10.1002/cbdv.202100033 EA JUN 2021 PG 12 WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary WE Science Citation Index Expanded (SCI-EXPANDED) SC Biochemistry & Molecular Biology; Chemistry GA TQ2AV UT WOS:000658906100001 PM 33991395 DA 2026-02-02 ER PT J AU Zheng, J Lee, J Byun, J Yu, D Ha, JH AF Zheng, Jiaxiang Lee, Jisu Byun, Jaemin Yu, Daeung Ha, Jung-Heun TI Partial replacement of high-fat diet with n-3 PUFAs enhanced beef tallow attenuates dyslipidemia and endoplasmic reticulum stress in tunicamycin-injected rats SO FRONTIERS IN NUTRITION LA English DT Article DE high fat high cholesterol diet; beef tallow; n-3 PUFAs; dyslipidemia; unfolded protein responses ID METABOLIC SYNDROME; MEDITERRANEAN DIET; INSULIN-RESISTANCE; CARDIOVASCULAR-DISEASE; GLUCOSE-TOLERANCE; ALPHA-TOCOPHEROL; LIVER-DISEASE; HEALTH VALUE; ER STRESS; ACIDS AB IntroductionMetabolic syndrome (MetS) is considered as a complex, intertwined multiple risk factors that directly increase the risk of various metabolic diseases, especially cardiovascular atherosclerotic diseases and diabetes mellitus type 2. While lifestyle changes, including dietary intervention are effective in mitigating or preventing MetS, there are no specific therapies against MetS. Typical western diets comprise of high saturated fatty acid, cholesterol, and simple sugar; consequently their consumption may increase the potential pathological developmental risk of MetS. Partial replacement of dietary fatty acids with polyunsaturated fatty acids (PUFAs) is widely recommended measure to manage MetS-related disorders. MethodsIn the present study, we used rat model to investigate the role of n-3 PUFA enriched beef tallows (BT) on MetS and tunicamycin (TM)-induced endoplasmic reticulum (ER) stress, by partially replacing dietary fat (lard) with equal amounts of two different BTs; regular BT or n-3 PUFA-enriched BT. The experimental rats were randomly assigned to three different dietary groups (n = 16 per group): (1) high-fat and high-cholesterol diet (HFCD); (2) HFCD partially replaced with regular BT (HFCD + BT1); (3) HFCD partially replaced with n-3 enhanced BT (w/w) (HFCD + BT2). After 10 weeks of dietary intervention, each experimental rodent was intraperitoneally injected with either phosphate-buffered saline or 1 mg/kg body weight of TM. ResultsHFCD + BT2 showed improved dyslipidemia before TM injection, and increased serum high-density lipoprotein cholesterol (HDL-C) levels after TM injection. BT replacement groups had significantly reduced hepatic triglyceride (TG) levels, and decreased total cholesterol (TC) and TG levels in epididymal adipose tissue (EAT). Furthermore, BT replacement remarkably attenuated TM-induced unfolded protein responses (UPRs) in liver, showing reduced ER stress, with BT2 being more effective in the EAT. DiscussionTherefore, our findings suggest that partially replacing dietary fats with n-3 PUFA to lower the ratio of n-6/n-3 PUFAs is beneficial in preventing pathological features of MetS by alleviating HFCD- and/or TM-induced dyslipidemia and ER stress. C1 [Zheng, Jiaxiang; Lee, Jisu; Ha, Jung-Heun] Dankook Univ, Dept Food Sci & Nutr, Cheonan, South Korea. [Byun, Jaemin] Hackensack Meridian Hlth, Ctr Discovery & Innovat, Nutley, NJ USA. [Yu, Daeung] Changwon Natl Univ, Dept Food & Nutr, Chang Won, South Korea. [Yu, Daeung] Changwon Natl Univ, Interdisciplinary Program Sr Human Ecol, Major Food & Nutr, Chang Won, South Korea. [Ha, Jung-Heun] Dankook Univ, Res Ctr Ind Nat Neutralizat, Yongin, South Korea. C3 Dankook University; Changwon National University; Changwon National University; Dankook University RP Ha, JH (通讯作者)，Dankook Univ, Dept Food Sci & Nutr, Cheonan, South Korea.; Yu, D (通讯作者)，Changwon Natl Univ, Dept Food & Nutr, Chang Won, South Korea.; Yu, D (通讯作者)，Changwon Natl Univ, Interdisciplinary Program Sr Human Ecol, Major Food & Nutr, Chang Won, South Korea.; Ha, JH (通讯作者)，Dankook Univ, Res Ctr Ind Nat Neutralizat, Yongin, South Korea. 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Nutr. PD MAR 16 PY 2023 VL 10 AR 1155436 DI 10.3389/fnut.2023.1155436 PG 15 WC Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Nutrition & Dietetics GA C0OQ6 UT WOS:000959021000001 PM 37006935 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Chatterjee, P Fernando, M Fernando, B Dias, CB Shah, T Silva, R Williams, S Pedrini, S Hillebrandt, H Goozee, K Barin, E Sohrabi, HR Garg, M Cunnane, S Martins, RN AF Chatterjee, Pratishtha Fernando, Malika Fernando, Binosha Dias, Cintia B. Shah, Tejal Silva, Renuka Williams, Shehan Pedrini, Steve Hillebrandt, Heidi Goozee, Kathryn Barin, Edward Sohrabi, Hamid R. Garg, Manohar Cunnane, Stephen Martins, Ralph N. TI Potential of coconut oil and medium chain triglycerides in the prevention and treatment of Alzheimer's disease SO MECHANISMS OF AGEING AND DEVELOPMENT LA English DT Review DE Medium chain triglycerides; Coconut oil; Alzheimer's disease; Cerebral glucose hypometabolism; Amyloid-beta ID CORONARY-HEART-DISEASE; FATTY-ACIDS; OXIDATIVE STRESS; KETOGENIC DIET; MEDITERRANEAN DIET; PLASMA-LIPIDS; BRAIN GLUCOSE; AMYLOID-BETA; LAURIC ACID; INSULIN-RESISTANCE AB Alzheimer's disease (AD) is the most common form of dementia. Currently, there is no effective medication for the prevention or treatment of AD. This has led to the search for alternative therapeutic strategies. Coconut oil (CO) has a unique fatty acid composition that is rich in medium chain fatty acids(MCFA), a major portion of which directly reaches the liver via the portal vein, thereby bypassing the lymphatic system. Given that brain glucose hypometabolism is a major early hallmark of AD, detectable well before the onset of symptoms, ketone bodies from MCFA metabolism can potentially serve as an alternative energy source to compensate for lack of glucose utilisation in the brain. Additionally, neuroprotective antioxidant properties of CO have been attributed to its polyphenolic content. This review discusses how the metabolism of CO and MCFA may aid in compensating the glucose hypometabolism observed in the AD brain. Furthermore, we present the current evidence of the neuroprotective properties of CO on cognition, amyloid-beta pathogenicity, inflammation and oxidative stress. The current review addresses the influence of CO/MCFA on other chronic disorders that are risk factors for AD, and addresses existing gaps in the literature regarding the use of CO/MCFA as a potential treatment for AD. C1 [Chatterjee, Pratishtha; Dias, Cintia B.; Shah, Tejal; Hillebrandt, Heidi; Goozee, Kathryn; Sohrabi, Hamid R.; Martins, Ralph N.] Macquarie Univ, Dept Biomed Sci, N Ryde, NSW, Australia. [Chatterjee, Pratishtha; Fernando, Binosha; Shah, Tejal; Pedrini, Steve; Goozee, Kathryn; Sohrabi, Hamid R.; Martins, Ralph N.] Edith Cowan Univ, Sch Med & Hlth Sci, Joondalup, WA, Australia. [Fernando, Malika; Silva, Renuka] Wayamba Univ Sri Lanka, Fac Livestock Fisheries & Nutr, Dept Appl Nutr, Kuliyapitiya, Sri Lanka. [Dias, Cintia B.; Garg, Manohar] Univ Newcastle, Sch Biomed Sci & Pharm, Nutraceut Res Program, Callaghan, NSW, Australia. [Williams, Shehan] Univ Kelaniya, Fac Med, Dept Psychiat, Colombo, Sri Lanka. [Goozee, Kathryn; Martins, Ralph N.] CRC Mental Hlth, Carlton, Vic, Australia. [Goozee, Kathryn] Anglicare, Clin Res Dept, Castle Hill, NSW, Australia. [Goozee, Kathryn; Martins, Ralph N.] KaRa Inst Neurol Dis, Macquarie Pk, NSW, Australia. [Barin, Edward] Macquarie Univ, Macquarie Univ Hosp, N Ryde, NSW, Australia. [Shah, Tejal; Sohrabi, Hamid R.; Martins, Ralph N.] Australian Alzheimer Res Fdn, Nedlands, WA, Australia. [Cunnane, Stephen] Univ Sherbrooke, Dept Med, Sherbrooke, PQ, Canada. [Cunnane, Stephen] Univ Sherbrooke, Res Ctr Aging, Sherbrooke, PQ, Canada. C3 Macquarie University; Edith Cowan University; Wayamba University of Sri Lanka; University of Newcastle; University of Colombo; University Kelaniya; Cooperative Research Centre for Mental Health; KaRa Minds; Macquarie University; Australian Alzheimer's Research Foundation; University of Sherbrooke; University of Sherbrooke RP Martins, RN (通讯作者)，Edith Cowan Univ, Sch Med Sci, 270 Joondalup Dr, Joondalup, WA 6027, Australia. EM r.martins@ecu.edu.au RI ; Chatterjee, Pratishtha/AER-9462-2022; Garg, Manohar/A-5795-2009; Botelho Dias, Cintia/M-1287-2014; Sohrabi, Hamid Reza/D-2744-2013; Silva, Ramon/PEX-7218-2025; Willia, Shehan/ABE-2984-2020; Barin, Edward/AAB-9567-2022; Fernando, Binosha/R-1114-2019 OI Peini, Steve/0000-0002-6409-8022; Chatterjee, Pratishtha/0000-0003-4877-1958; Martins, Ralph/0000-0002-4828-9363; Goozee, Kathryn/0000-0002-3573-1554; Hillebrandt, Heidi/0000-0003-0311-1470; Fernando, Malika Gayathri/0000-0002-4021-2943; Garg, Manohar/0000-0003-0514-0865; Shah, Tejal/0000-0002-3069-3835; Botelho Dias, Cintia/0000-0002-5507-3472; Sohrabi, Hamid Reza/0000-0001-8017-8682; Willia, Shehan/0000-0001-7764-5550; Barin, Edward/0000-0001-8593-4635; FU Chemrez Technologies; Nestle FX RNM has received part funding from Chemrez Technologies to undertake a clinical trial to evaluate the safety and efficacy of medium chain triglycerides extracted from coconut oil on a high-risk AD cohort. SCC has consulted for and/or received travel support from Pruvit, Nisshin Oillio and Accera, has received test materials for research from Nestle, Abitec, Bulletproof and HYMN, and has received funding for research from Nestle. SCC is president and sole shareholder of Senotec, a company developing keto-neurotherapeutics. 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Ageing Dev. PD MAR PY 2020 VL 186 AR 111209 DI 10.1016/j.mad.2020.111209 PG 10 WC Cell Biology; Geriatrics & Gerontology WE Science Citation Index Expanded (SCI-EXPANDED) SC Cell Biology; Geriatrics & Gerontology GA KT2TR UT WOS:000518869000008 PM 31953123 DA 2026-02-02 ER PT J AU Ganesan, K Jayachandran, M Xu, BJ AF Ganesan, Kumar Jayachandran, Muthukumaran Xu, Baojun TI Diet-Derived Phytochemicals Targeting Colon Cancer Stem Cells and Microbiota in Colorectal Cancer SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES LA English DT Review DE phytochemicals; gut microbiota; colon cancer stem cells; CRC therapy ID FATTY LIVER-DISEASE; GUT MICROBIOTA; BETA-CATENIN; INTESTINAL MICROBIOTA; MEDITERRANEAN DIET; PROSTATE-CANCER; INDUCED OBESITY; IN-VITRO; PATHWAYS; POLYPHENOLS AB Colorectal cancer (CRC) is a fatal disease caused by the uncontrolled propagation and endurance of atypical colon cells. A person's lifestyle and eating pattern have significant impacts on the CRC in a positive and/or negative way. Diet-derived phytochemicals modulate the microbiome as well as targeting colon cancer stem cells (CSCs) that are found to offer significant protective effects against CRC, which were organized in an appropriate spot on the paper. All information on dietary phytochemicals, gut microbiome, CSCs, and their influence on CRC were accessed from the various databases and electronic search engines. The effectiveness of CRC can be reduced using various dietary phytochemicals or modulating microbiome that reduces or inverses the progression of a tumor as well as CSCs, which could be a promising and efficient way to reduce the burden of CRC. Phytochemicals with modulation of gut microbiome continue to be auspicious investigations in CRC through noticeable anti-tumorigenic effects and goals to CSCs, which provides new openings for cancer inhibition and treatment. C1 [Ganesan, Kumar; Jayachandran, Muthukumaran; Xu, Baojun] Beijing Normal Univ Hong Kong Baptist Univ United, Food Sci & Technol Programme, Zhuhai 519087, Peoples R China. [Ganesan, Kumar] Univ Hong Kong, Lab & Clin Res Inst Pain, Dept Anesthesiol, Hong Kong, Peoples R China. C3 Beijing Normal-Hong Kong Baptist University; Hong Kong Baptist University; University of Hong Kong RP Xu, BJ (通讯作者)，Beijing Normal Univ Hong Kong Baptist Univ United, Food Sci & Technol Programme, Zhuhai 519087, Peoples R China. 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PD JUN PY 2020 VL 21 IS 11 AR 3976 DI 10.3390/ijms21113976 PG 26 WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary WE Science Citation Index Expanded (SCI-EXPANDED) SC Biochemistry & Molecular Biology; Chemistry GA MC6ND UT WOS:000543400300238 PM 32492917 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Tanaka, N Kono, H Ishii, K Hosomura, N Fujii, H AF Tanaka, Nobuyuki Kono, Hiroshi Ishii, Kenichi Hosomura, Naohiro Fujii, Hideki TI Dietary olive oil prevents carbon tetrachloride-induced hepatic fibrosis in mice SO JOURNAL OF GASTROENTEROLOGY LA English DT Article DE Fatty acid; Hepatic stellate cells; Transforming growth factor-beta 1 ID MEDIUM-CHAIN TRIGLYCERIDES; LIVER FIBROSIS; STELLATE CELLS; FATTY-ACID; OLEIC-ACID; ITO CELLS; MEDITERRANEAN DIET; OXIDATIVE STRESS; INJURY; RATS AB The specific purpose of this study was to investigate the effects of dietary olive oil on hepatic fibrosis induced by chronic administration of carbon tetrachloride (CCl4) in the mouse. In addition, the effects of oleic acid, a major component of olive oil, on activation of hepatic stellate cells (HSCs) were investigated in vitro. Mice were fed liquid diets containing either corn oil (control, AIN-93) or olive oil (6.25 g/L) throughout experiments. Animals were treated with CCl4 for 4 weeks intraperitoneally. The mRNA expression of TGF-beta 1 and collagen 1 alpha 2 (col1 alpha 2) in the liver was assessed by reverse transcriptase-polymerase chain reaction (RT-PCR). The HSCs were isolated from mice, and co-cultured with either oleic acid (100 mu M) or linoleic acid (100 mu M) for 2 days. The expression of alpha-smooth muscle actin (alpha-SMA) was assessed by immunohistochemistry. In addition, the production of hydroxyproline was determined. Serum alanine aminotransferase levels and the mRNA expression of TGF-beta and coll alpha 2 were significantly reduced by treatment of olive oil. Dietary olive oil blunted the expression of alpha-SMA in the liverand liver injury and hepatic fibrosis were prevented by treatment of olive oil. The number of alpha-SMA positive cells was significantly lower in HSCs co-cultured with oleic acid than in those co-cultured with linoleic acid. Concentration of hydroxyproline in culture medium was significantly lower in cells co-cultured with oleic acid than in the control. Dietary olive oil prevents CCl4-induced tissue injury and fibrosis in the liver. Since oleic acid inhibited activation of HSCs, oleic acid may play a key role on this mechanism. C1 [Tanaka, Nobuyuki; Kono, Hiroshi; Ishii, Kenichi; Hosomura, Naohiro; Fujii, Hideki] Univ Yamanashi, Fac Med, Dept Surg 1, Chuo Ku, Yamanashi 4093898, Japan. C3 University of Yamanashi RP Kono, H (通讯作者)，Univ Yamanashi, Fac Med, Dept Surg 1, Chuo Ku, 1110 Shimokato, Yamanashi 4093898, Japan. 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Gastroenterol. PD SEP PY 2009 VL 44 IS 9 BP 983 EP 990 DI 10.1007/s00535-009-0088-9 PG 8 WC Gastroenterology & Hepatology WE Science Citation Index Expanded (SCI-EXPANDED) SC Gastroenterology & Hepatology GA 496FU UT WOS:000269955900012 PM 19506795 DA 2026-02-02 ER PT J AU Khedr, A Alahdal, AM AF Khedr, Alaa Alahdal, A. M. TI Optimized Gas Chromatography-Mass Spectrometric Method to Profile Esterified Fatty Acids in Fish Roe and Fish Oil SO INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES LA English DT Article DE Fish roe; fish oil; esterified fatty acids; gas chromatography-mass spectrometry ID MEDITERRANEAN DIET; PHOSPHOLIPIDS; TRANSESTERIFICATION AB A gas chromatography-mass spectrometric method was optimized and applied to profile the major esterified fatty acids in eight lyophilized fish roe species and three marketed fish oil capsules. The method was able to separate efficiently 36 standard fatty acids as methyl esters using Teknokroma fused silica capillary column, 60 mx0.25 mmx0.2 mu m. However, only 20 major esterified fatty acids were determined in fish roe and fish oil samples. The total amount of esterified fatty acids in salmon wild oil, salmon cold water oil and cod liver oil capsules were 235.5, 145.8, and 195.5 mg/g, respectively. However, the total amount of esterified fatty acids in fish roe species ranged from 40 to 61 mg/g. The quantitation data were treated with statistical principal component analysis, and showed a characteristic score value for each type of fish roe. Each type of fish roe showed a characteristic content profile of 20 major esterified fatty acids. The highest concentration of esterified omega-3, was found in salmon fish roe (15.34 mg/g) and Mosa fish roe (13.15 mg/g). The maximum amount of esterified alpha-linolenic acid, eicosapentaenoic acid and docosahexaenoic acid were found in salmon wild oil (7.73 mg/g), salmon fish roe (6.09 mg/g), and Mosa fish roe (11.00 mg/g), respectively. The developed method was found to be applicable for qualification and characterization of fish roe and fish oil. C1 [Khedr, Alaa] King Abdulaziz Univ, Fac Pharm, Dept Pharmaceut Chem, POB 80260, Jeddah 21589, Saudi Arabia. [Alahdal, A. M.] King Abdulaziz Univ, Fac Pharm, Dept Clin Pharm, POB 80260, Jeddah 21589, Saudi Arabia. C3 King Abdulaziz University; King Abdulaziz University RP Khedr, A (通讯作者)，King Abdulaziz Univ, Fac Pharm, Dept Pharmaceut Chem, POB 80260, Jeddah 21589, Saudi Arabia. EM akhedr@kau.edu.sa RI Khe, Alaa/A-3985-2015; Alahdal, Abduarahman/G-8230-2018 OI Khe, Alaa/0000-0003-1057-7455; FU Deanship of Scientific Research (DSR), at King Abdulaziz University, Jeddah [147/166/1437] FX This project was funded by the Deanship of Scientific Research (DSR), at King Abdulaziz University, Jeddah, under grant no. 147/166/1437. The authors, therefore, acknowledge with thanks DSR for technical and financial support. 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Pharm. Sci. PD JUL-AUG PY 2018 VL 80 IS 4 BP 628 EP 636 DI 10.4172/pharmaceutical-sciences.1000402 PG 9 WC Pharmacology & Pharmacy WE Science Citation Index Expanded (SCI-EXPANDED) SC Pharmacology & Pharmacy GA HG7OV UT WOS:000455182700006 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Perona, JS AF Perona, Javier S. TI Membrane lipid alterations in the metabolic syndrome and the role of dietary oils SO BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES LA English DT Review DE Metabolic syndrome; Membrane; Insulin resistance; Phospholipids; Fatty acids; Dietary oil ID CARDIOVASCULAR RISK-FACTORS; FATTY-ACID-COMPOSITION; VIRGIN OLIVE OIL; DENSITY-LIPOPROTEIN CHOLESTEROL; MEDITERRANEAN-STYLE DIET; INSULIN-RESISTANCE; DOCOSAHEXAENOIC ACID; BLOOD-PRESSURE; EICOSAPENTAENOIC ACID; GLUCOSE-TRANSPORT AB The metabolic syndrome is a cluster of pathological conditions, including hypertension, hyperglycemia, hypertriglyceridemia, obesity and low HDL levels that is of great concern worldwide, as individuals with metabolic syndrome have an increased risk of type-2 diabetes and cardiovascular disease. Insulin resistance, the key feature of the metabolic syndrome, might be at the same time cause and consequence of impaired lipid composition in plasma membranes of insulin-sensitive tissues like liver, muscle and adipose tissue. Diet intervention has been proposed as a powerful tool to prevent the development of the metabolic syndrome, since healthy diets have been shown to have a protective role against the components of the metabolic syndrome. Particularly, dietary fatty acids are capable of modulating the deleterious effects of these conditions, among other mechanisms, by modifications of the lipid composition of the membranes in insulin-sensitive tissues. However, there is still scarce data based of high-level evidence on the effects of dietary oils on the effects of the metabolic syndrome and its components. This review summarizes the current knowledge on the effects of dietary oils on improving alterations of the components of the metabolic syndrome. 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Biophys. Acta-Biomembr. PD SEP PY 2017 VL 1859 IS 9 SI SI BP 1690 EP 1703 DI 10.1016/j.bbamem.2017.04.015 PN B PG 14 WC Biochemistry & Molecular Biology; Biophysics WE Science Citation Index Expanded (SCI-EXPANDED) SC Biochemistry & Molecular Biology; Biophysics GA FB2LD UT WOS:000405974400019 PM 28428072 DA 2026-02-02 ER PT J AU Pinto, W Engrola, S Santos, A Bandarra, NM Dias, J Conceiçao, LEC AF Pinto, Wilson Engrola, Sofia Santos, Andre Bandarra, Narcisa M. Dias, Jorge Conceicao, Luis E. C. TI Can Senegalese sole post-larvae effectively grow on low dietary DHA and lipid levels during weaning? SO AQUACULTURE LA English DT Article DE Lipids; Fatty acids; Docosahexaenoic acid; Sole; Weaning; Microdiet ID FLOUNDER PARALICHTHYS-OLIVACEUS; POLYUNSATURATED FATTY-ACIDS; KAUP 1858 LARVAE; SCOPHTHALMUS-MAXIMUS; NUTRIENT UTILIZATION; BODY-COMPOSITION; ENERGY-LEVELS; MARINE FISH; PROTEIN; PERFORMANCE AB Senegalese sole (Solea senegalensis) is a highly-valuable flatfish species with interest for diversification of aquaculture in Mediterranean countries. Unlike other fish species known to have a high dietary DHA requirement during the larval stage, several studies have suggested dietary DHA could play a minor role for Senegalese sole during the early developmental stages. This suggestion was recently supported by studies that indicated an ability of Senegalese sole to biosynthesise DHA from its precursors during the larval period. However, it is still uncertain if Senegalese sole post-larvae can effectively grow on low dietary DHA levels during weaning. Moreover, recent studies focusing on the juvenile phase of Senegalese sole have suggested a possible impairment of this species to efficiently digest or absorb high dietary lipid levels. Yet, if a reduction of dietary lipid levels would affect a normal development of Senegalese sole during the early stages remains to be established. Therefore, this study aimed at determining if a reduction of dietary DHA and lipid levels would affect Senegalese sole performance and lipidme-tabolism duringweaning and post-larval period. In this study, Senegalese sole post-larvae were reared according to four dietary treatments: low lipid levels (treatments LFAT and LFAT_DHA) and moderate lipid levels (MOD-FAT and MODFAT_DHA). DHA levels in LFAT_DHA and MODFAT_DHA diets were higher than in LFAT and MOD-FAT diets, respectively. Subsequently, effects of experimental diets on Senegalese sole post-larval growth, survival, fatty acid composition and histopathological condition of intestinal and liver tissues were evaluated. Results showed that feeding on diets with low DHA and lipid levels significantly reduced the growth performance of Senegalese sole post-larvae. However, at the end of the experimental period, no significant differences were observed for post-larval survival in response to dietary treatments. In overall, this study disadvises that weaning diets for Senegalese sole post-larvae should contain low DHA and lipid levels, as a reduction of these levels may compromise post-larval growth performance. Statement of relevance: Determining essential fatty acid requirements in marine fish larvae is of utmost importance for the aquaculture industry, contributing to fulfil the growth potential of farmed species. In the case of Senegalese sole, a highly valued species farmed in Mediterranean countries, it may have the capacity to biosynthesise DHA from its precursors during the larval stage. However, the inclusion of DHA-rich oils in weaning diets is costly, considerable savings could be achieved by replacing DHA-rich oils by common fish oils in weaning diets for this species. Furthermore, Senegalese sole has also been shown a poor ability to deal with high dietary lipid levels during the juvenile stage. However, no studies have addressed this capacity in Senegalese sole larvae. This study comprises an evaluation on the effects of reducing dietary DHA and lipid levels during Senegalese sole weaning by integrating an assessment of these effects on post-larval growth, survival, fatty acid composition and histopathological condition. (C) 2016 Elsevier B.V. All rights reserved. C1 [Pinto, Wilson; Santos, Andre; Dias, Jorge; Conceicao, Luis E. C.] Sparos Lda, Area Empresarial Marim, P-8700221 Olhao, Portugal. [Bandarra, Narcisa M.] IPMA, Av Brasilia, P-1449006 Lisbon, Portugal. [Engrola, Sofia] Univ Algarve, CCMAR, Campus Gambelas, P-8005139 Faro, Portugal. C3 Instituto Portugues do Mar e da Atmosfera; Universidade do Algarve RP Pinto, W (通讯作者)，Sparos Lda, Area Empresarial Marim, P-8700221 Olhao, Portugal. EM wilsonpinto@sparos.pt RI ; Conceicao, Luis/I-3037-2013; Pinto, Wilson/G-5996-2012; Dias, Jorge/A-2820-2012; Bandarra, Narcisa/C-4780-2013; Engrola, Sofia/A-2485-2012 OI Santos, André/0009-0006-2493-2381; Conceicao, Luis/0000-0001-6102-2068; Pinto, Wilson/0009-0005-8585-7373; Dias, Jorge/0000-0003-2796-2624; Bandarra, Narcisa/0000-0002-7563-9226; Engrola, Sofia/0000-0002-5244-5541 FU PROMAR Program (Portugal) [310305/FEP/71]; FEDER funds; European Social Fund [IF/00482/2014/CP1217/CT0005]; Operational Programme Human Potential; Foundation for Science and Technology of Portugal (FCT-Portugal) FX The authors acknowledge technical support from Helena Teixeira during fish rearing. This work was undertaken in the framework of project SOLEAWIN (310305/FEP/71) partially supported by PROMAR Program (Portugal) with FEDER funds. Sofia Engrola acknowledges a FCT investigator grant IF/00482/2014/CP1217/CT0005 funded by the European Social Fund, the Operational Programme Human Potential and the Foundation for Science and Technology of Portugal (FCT-Portugal). 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Many studies on the GM in CVD have been published in the last decade. However, bibliometric analysis in this field is still lacking. MethodsOn 30 September 2022, a search of the Web of Science (TM) (WoS; Clarivate (TM), Philadelphia, PA, USA) yielded 1,500 articles and reviews on the GM and CVD. Microsoft Excel and CiteSpace and VOSviewer software were used to analyze publication trends and research hotspots in this field. ResultsOur search generated 1,708 publications on the GM in CVD published between 2004 and 2022, and 1,500 articles and review papers were included in the final analysis. The number of publications relating to the GM in CVD increased from 1 in 2004 to 350 in 2021. China (485 publications, 9,728 non-self-citations, and an H-index of 47) and the USA (418 publications, 24,918 non-self-citations, and an H-index of 82) contributed 32.31%, and 27.85%, respectively, of the total number of publications. Examination of the number of publications (Np) and number of citations, excluding self-citations (Nc), of individual authors showed that Y. L. Tian (Np: 18, Nc: 262, and H-index: 12), from China, is the most productive author, followed by R. Knight (Np: 16, Nc: 3,036, and H-index: 15) and M. Nieuwdorp (Np: 16, Nc: 503, and H-index: 9). The Chinese Academy of Medical Sciences and Peking Union Medical College accounted for the largest number of publications (Np: 62, Nc: 3,727, and H-index: 13, average citation number (ACN): 60.11). The journal Nutrients had the most publications (Np: 73, Nc: 2,036, and ACN: 27.89). The emerging keywords in this field were "monooxygenase 3" (strength 3.24, 2020-2022), "short-chain fatty acid" (strength 4.63, 2021-2022), "fatty liver disease" (strength 3.18, 2021-2022), "metabolic disease" (strength 3.04, 2021-2022), "Mediterranean diet" (strength 2.95, 2021-2022), "prevention" (strength 2.77, 2021-2022), and "intestinal barrier" (strength 2.8, 2021-2022). ConclusionPublications on the GM in CVD rapidly increased in the last decade. The USA was the most influential country in publications in this field, followed by China. The journal with the most publications was Nutrients. Monooxygenase-3, short-chain fatty acids, fatty liver disease, metabolic disease, the Mediterranean diet, intestinal barrier, and prevention are the current hotspots or potential hotspots for future study. C1 [Sheng, Ming; Ouyang, Yi-xiang] Gannan Med Univ, Dept Lib, Ganzhou, Jiangxi, Peoples R China. [Xu, Shuquan] Gannan Med Univ, Sch Basic Med, Ganzhou, Jiangxi, Peoples R China. [Chen, Wei-wei] Gannan Med Univ, Dept Pharmacol, Ganzhou, Jiangxi, Peoples R China. [Li, Fa-quan; Zhong, Yi-ming; Liao, Yong-ling; Lai, Ping] Gannan Med Univ, Hosp 1, Dept Cardiol, Ganzhou, Jiangxi, Peoples R China. [Li, Fa-quan; Zhong, Yi-ming; Liao, Yong-ling; Lai, Ping] Gannan Med Univ, Key Lab Prevent & Treatment Cardiovasc & Cerebrova, Minist Educ, Ganzhou, Peoples R China. C3 Gannan Medical University; Gannan Medical University; Gannan Medical University; Gannan Medical University; Gannan Medical University RP Liao, YL; Lai, P (通讯作者)，Gannan Med Univ, Hosp 1, Dept Cardiol, Ganzhou, Jiangxi, Peoples R China.; Liao, YL; Lai, P (通讯作者)，Gannan Med Univ, Key Lab Prevent & Treatment Cardiovasc & Cerebrova, Minist Educ, Ganzhou, Peoples R China. EM liaoyongling9196@163.com; p.lai.ext@uke.de RI Lai, Ping/PGL-9432-2026 FU Natural Science Foundation of Jiangxi Province [20202BABL206012]; Open Project of Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases, Ministry of Education [170865]; Science and Technology Research Project of Education Department of Jiangxi Province [202008360179]; Gannan Medical University Project; CSC scholarship; National Public Fund for Study Abroad; [XN201804]; [YB201803] FX This work was supported by the Natural Science Foundation of Jiangxi Province (No.20202BABL206012) (Y-lL), by the Open Project of Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases, Ministry of Education (No. XN201804) (Y-mZ), by Science and Technology Research Project of Education Department of Jiangxi Province (No.170865) (PL), and Gannan Medical University Project (No. YB201803) (PL), The National Public Fund for Study Abroad and CSC scholarship (Grant NO. 202008360179) (PL). 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Cell. Infect. Microbiol. PD JAN 6 PY 2023 VL 12 AR 1083995 DI 10.3389/fcimb.2022.1083995 PG 14 WC Immunology; Microbiology WE Science Citation Index Expanded (SCI-EXPANDED) SC Immunology; Microbiology GA 8A2IR UT WOS:000916068100001 PM 36683688 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Shi, RY Huang, CY Gao, Y Li, X Zhang, CH Li, MH AF Shi, Ruyu Huang, Congying Gao, Yuan Li, Xing Zhang, Chunhong Li, Minhui TI Gut microbiota axis: potential target of phytochemicals from plant-based foods SO FOOD SCIENCE AND HUMAN WELLNESS LA English DT Article DE Gut microbiota axis; Disease mechanisms; Plant-based foods; Phytochemicals ID CHAIN FATTY-ACIDS; DEPRESSION-LIKE BEHAVIOR; ALZHEIMERS-DISEASE; KIDNEY-DISEASE; BRAIN AXIS; INTESTINAL MICROBIOTA; DIETARY POLYPHENOLS; MEDITERRANEAN DIET; CANCER RISK; CROSS-TALK AB Food-microbiota-host interactions provide an overarching framework for understanding the function of the gut microbiota axis. Diet is a major modulator of gut microbiota. Plant-based foods are rich in phytochemicals; therefore, it is essential to assess such foods and elucidate the mechanisms underlying their action. In this review, we summarize the role of gut microbiota in the communication between the gut and the brain, liver, lung, kidney, and joints, as well as the role of the gut microbiota axis in diseases involving these organs. In addition, we assess the effects of phytochemicals from plant-based foods on the gut microbiota axis via different pathways. (c) 2023 Beijing Academy of Food Sciences. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co., Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). C1 [Shi, Ruyu; Huang, Congying; Li, Xing; Zhang, Chunhong; Li, Minhui] Baotou Med Coll, Baotou 014040, Peoples R China. [Shi, Ruyu; Gao, Yuan; Li, Minhui] Inner Mongolia Hosp Tradit Chinese Med, Hohhot 010020, Peoples R China. [Zhang, Chunhong] Baotou Med Coll, Inner Mongolia Key Lab Tradit Chinese Resources, Baotou 014040, Peoples R China. [Zhang, Chunhong] Inner Mongolia Engn Res Ctr, Planting & Dev Astragalus Membranaceus Geoherbs, Baotou 014040, Peoples R China. [Li, Minhui] Baotou Med Coll, Inner Mongolia Key Lab Characterist Geoherbs Reso, Baotou 014040, Peoples R China. C3 Baotou Medical College; Baotou Medical College; Baotou Medical College RP Zhang, CH; Li, MH (通讯作者)，Baotou Med Coll, Baotou 014040, Peoples R China. EM zchlhh@126.com; prof_liminhui@yeah.net RI Zhang, Chunhong/HGB-8244-2022 FU National Key Research and Development Program [2021YFE0190100]; National Natural Science Foundation of China [81760776, 81874336] FX This work was supported by the National Key Research and Development Program (2021YFE0190100); National Natural Science Foundation of China (81760776, 81874336). 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Human Wellness PD SEP PY 2023 VL 12 IS 5 BP 1409 EP 1426 DI 10.1016/j.fshw.2023.02.001 PG 18 WC Food Science & Technology; Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Food Science & Technology; Nutrition & Dietetics GA U8QG6 UT WOS:001087386900001 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Chen, PY Fang, AP Wang, XY Lan, QY Liao, GC Liu, ZY Zhang, DM Zhang, YY Chen, YM Zhu, HL AF Chen, Pei-Yan Fang, Ai-Ping Wang, Xiao-Yan Lan, Qiu-Ye Liao, Gong-Cheng Liu, Zhao-Yan Zhang, Dao-Ming Zhang, Yao-Yun Chen, Yu-Ming Zhu, Hui-Lian TI Adherence to the Chinese or American Dietary Guidelines is Associated with a Lower Risk of Primary Liver Cancer in China: A Case-Control Study SO NUTRIENTS LA English DT Article DE dietary index; diet; liver cancer; risk factors; case-control study ID HEPATOCELLULAR-CARCINOMA; QUALITY SCORES; FATTY LIVER; MEDITERRANEAN DIET; PATTERN-ANALYSIS; REDUCES RISK; INDEX; CONSUMPTION; INFLAMMATION; DISEASE AB Adherence to healthy dietary guidelines has been related to a lower risk of several cancers, but its role in primary liver cancer (PLC) has not been fully investigated, especially among Eastern populations. This study enrolled 720 PLC patients and 720 healthy controls who were frequency-matched by age and sex between September 2013 and October 2017 in South China. Dietary quality was assessed by the Chinese Healthy Eating Index (CHEI) and the Healthy Eating Index 2015 (HEI-2015), which manifests as scores of adhering to the 2016 Dietary Guidelines for Chinese and adhering to the 2015-2020 Dietary Guidelines for Americans, respectively. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using unconditional logistic regression models, adjusting for potential confounders. Higher scores in both the CHEI and HEI-2015 were associated with a lower risk of PLC (per 5-points increment of the total scores: OR: 0.43, 95% CI: 0.38-0.50 for CHEI; OR: 0.47, 95% CI: 0.40-0.55 for HEI-2015). The protective associations persisted significantly in the stratified analyses by sex, smoker status, alcohol consumption, HBV infection, and histological types of PLC, without statistical evidence for heterogeneity (p-interaction > 0.05). Closer adherence to the most recent dietary guidelines for Chinese or Americans may protect against PLC. C1 [Chen, Pei-Yan; Fang, Ai-Ping; Wang, Xiao-Yan; Lan, Qiu-Ye; Liao, Gong-Cheng; Liu, Zhao-Yan; Zhang, Dao-Ming; Zhu, Hui-Lian] Sun Yat Sen Univ, Sch Publ Hlth, Dept Nutr, Guangzhou 510080, Guangdong, Peoples R China. [Zhang, Yao-Yun] Sun Yat Sen Univ, Canc Ctr, Dept Hepatobiliary Surg, Guangzhou 510060, Guangdong, Peoples R China. [Chen, Yu-Ming; Zhu, Hui-Lian] Guangdong Prov Key Lab Food Nutr & Hlth, Guangzhou 510080, Guangdong, Peoples R China. [Chen, Yu-Ming] Sun Yat Sen Univ, Sch Publ Hlth, Dept Med Stat & Epidemiol, Guangzhou 510080, Guangdong, Peoples R China. C3 Sun Yat Sen University; Sun Yat Sen University; Sun Yat Sen University RP Zhu, HL (通讯作者)，Sun Yat Sen Univ, Sch Publ Hlth, Dept Nutr, Guangzhou 510080, Guangdong, Peoples R China.; Zhu, HL (通讯作者)，Guangdong Prov Key Lab Food Nutr & Hlth, Guangzhou 510080, Guangdong, Peoples R China. EM chpyan@mail2.sysu.edu.cn; fangaip@mail.sysu.edu.cn; wangxy277@mail2.sysu.edu.cn; bolivia.lan@gmail.com; liaogch3@mail2.sysu.edu.cn; liuzhy69@mail2.sysu.edu.cn; zhangdm3@mail2.sysu.edu.cn; zhangyuj@sysucc.org.cn; chenyum@mail.sysu.edu.cn; zhuhl@mail.sysu.edu.cn RI Zhu, Huilian/V-1040-2019; Zhang, Daoming/MYS-2941-2025; Fang, Aiping/V-1792-2019; Liu, Zhao-Yan/HNS-0141-2023 OI chen, Yu-ming/0000-0003-1658-5528; Lan, Qiu-Ye/0000-0002-2697-6664; FU National Nature Science Foundation of China [81472966, 81273050]; Key Program of National Nature Science Foundation of Guangdong, China [2015A030311035] FX This research was funded by the National Nature Science Foundation of China (No. 81472966 and 81273050) and Key Program of National Nature Science Foundation of Guangdong, China (No. 2015A030311035). 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Objective: this retrospective longitudinal study aims to analyse the growth trajectories of a cohort of children with CL/P and compare them with a healthy representative cohort of children from Aragon (Spain).Methods: type of cleft, surgical technique and sequelae, and weight, length/height and body mass index (BMI) (weight/height2) at different ages (0-6 years) were recorded. Normalized age- and sex-specific anthropometric Z-scores values were calculated by World Health Organization (WHO) charts.Results: forty-one patients (21 male, 20 female) were finally included: 9.75 % cleft lip (n = 4/41), 41.46 % cleft palate (n = 17/41) and 48.78 % cleft lip and palate (n = 20/41). The worst nutritional status Z-scores were achieved at the age of three months (44.44 % and 50 % had a weight and a BMI lower than -1 Z-score, respectively). Mean weight and BMI Z-scores were both significantly lower than controls at one, three and six months of age, recovering from that moment until the age of one year.Conclusions: the highest nutritional risk in CL/P patients takes place at 3-6 months of age, but nutritional status and growth trajectories get recovered from one year of age compared to their counterparts. Nevertheless, the rate of thin subjects among CL/P patients is higher during childhood. C1 [Gallego, Rocio; Iglesia-Altaba, Iris; Rodriguez, Gerardo] Aragon Inst Hlth Res IIS Aragon, Zaragoza, Spain. [Gallego, Rocio; Moral, Ignacio; Rodriguez, Gerardo] Univ Zaragoza, Zaragoza, Spain. [Iglesia-Altaba, Iris; Rodriguez, Gerardo] Univ Zaragoza, Fac Hlth Sci, Growth Exercise Nutr & Dev GENUD Res Grp, Zaragoza, Spain. [Iglesia-Altaba, Iris; Rodriguez, Gerardo] Inst Agroalimentario Aragon IA2, Zaragoza, Spain. [Iglesia-Altaba, Iris; Rodriguez, Gerardo] RETICS Inst Salud Carlos III, Maternal & Infant Hlth & Dev Network SAMID, Madrid, Spain. [Moral, Ignacio; Iso, Ivan; Delso, Elena] Hosp Univ Miguel Servet, Oral & Maxillofacial Surg Serv, Zaragoza, Spain. [Rodriguez, Gerardo] Univ Zaragoza, Fac Med, Pediat Area, Domingo Miral S-N 50, Zaragoza 50009, Spain. C3 University of Zaragoza; University of Zaragoza; Miguel Servet University Hospital; University of Zaragoza RP Rodríguez, G (通讯作者)，Univ Zaragoza, Fac Med, Pediat Area, Domingo Miral S-N 50, Zaragoza 50009, Spain. RI Rodriguez Martínez, Gerardo/AAG-9855-2020; Iglesia, Iris/C-1841-2014 FU Carlos III Health Institute [PI08/0559, PI13/02359, RD12/0026, 20089-2011] FX this study was supported by three grants from the Carlos III Health Institute: 1. PI08/0559: Aragon Health Sciences Institute for the Growth and Feeding in Infants from Aragon (CALINA) project. 2. PI13/02359: Environmental factors influencing early development of obesity during childhood and body composition programming. 3. RD12/0026: Maternal, Child Health and Development Network (Retic SAMID) RETICS funded by the PN I + D + I 20089-2011 (Spain) , ISCIII-Sub-Directorate General for Research Assessment and Promotion and the European Regional Development Fund (ERDF) . 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Hosp. PD JUL-AUG PY 2023 VL 40 IS 4 BP 717 EP 723 DI 10.20960/nh.04620 PG 7 WC Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Nutrition & Dietetics GA X6SO7 UT WOS:001099729300010 PM 37334810 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Muscogiuri, G Verde, L Sulu, C Katsiki, N Hassapidou, M Frias-Toral, E Cucalón, G Pazderska, A Yumuk, VD Colao, A Barrea, L AF Muscogiuri, Giovanna Verde, Ludovica Sulu, Cem Katsiki, Niki Hassapidou, Maria Frias-Toral, Evelyn Cucalon, Gabriela Pazderska, Agnieszka Yumuk, Volkan Demirhan Colao, Annamaria Barrea, Luigi TI Mediterranean Diet and Obesity-related Disorders: What is the Evidence? SO CURRENT OBESITY REPORTS LA English DT Article DE Mediterranean diet; Obesity; Obesity-related disorders; Cardiovascular diseases; Type 2 diabetes; Dyslipidemia ID BREAST-CANCER RISK; FATTY LIVER-DISEASE; BODY-MASS INDEX; CORONARY-HEART-DISEASE; ALL-CAUSE MORTALITY; VITAMIN-D-STATUS; CARDIOVASCULAR-DISEASE; WEIGHT-LOSS; MYOCARDIAL-INFARCTION; HEPATIC MANIFESTATION AB Purpose of Review Obesity is a chronic disease, a major public health problem due to its association with non-communicable diseases and all-cause mortality. Indeed, people with obesity are at increased risk for a variety of obesity-related disorders including hypertension, dyslipidemia, type 2 diabetes mellitus, cardiovascular disease, and several cancers. Many popular diets with very different macronutrient composition, including the Mediterranean diet (MD), have been used, proposed, and studied for prevention and management of obesity. In particular, MD has been the subject of countless studies over the years and now boasts a large body of scientific literature. In this review, we aimed to update current knowledge by summarizing the most recent evidence on the effect of MD on obesity and obesity-related disorders. Recent Findings The negative effects of obesity are partly reversed by substantial weight loss that can be achieved with MD, especially when low-calorie and in combination with adequate physical activity. In addition, the composition of MD has been correlated with an excellent effect on reducing dyslipidemia. It also positively modulates the gut microbiota and immune system, significantly decreasing inflammatory mediators, a common ground for many obesity-related disorders. Summary People with obesity are at increased risk for a variety of medical disorders including hypertension, dyslipidemia, type 2 diabetes mellitus, and cardiovascular disease. Therefore, there is an inevitable need for measures to manage obesity and its related disorders. At this point, MD has been proposed as a valuable nutritional intervention. It is characterized by a high consumption of vegetables, fruit, nuts, cereals, whole grains, and extra virgin olive oil, as well as a moderate consumption of fish and poultry, and a limited intake of sweets, red meat, and dairy products. MD proves to be the healthiest dietary pattern available to tackle obesity and prevent several non-communicable diseases, including cardiovascular disease and type 2 diabetes. C1 [Muscogiuri, Giovanna; Colao, Annamaria] Univ Federico II, Endocrinol Unit, Dipartimento Med Clin & Chirurg, Naples, Italy. [Muscogiuri, Giovanna; Verde, Ludovica; Colao, Annamaria; Barrea, Luigi] Univ Med Sch Naples, Ctr Italiano Cura & Benessere Paziente Con Obes C, Dept Clin Med & Surg, Endocrinol Unit, Naples, Italy. [Muscogiuri, Giovanna; Colao, Annamaria] Univ Federico II, Cattedra Unesco Educ Salute & Allo Sviluppo Soste, Naples, Italy. [Sulu, Cem; Yumuk, Volkan Demirhan] Cerrahpasa Med Fac, Istanbul Univ Cerrahpasa, Div Endocrinol Metab & Diabet, Istanbul, Turkey. [Katsiki, Niki; Hassapidou, Maria] Int Hellen Univ, Dept Nutr Sci & Dietet, Thessaloniki, Greece. [Frias-Toral, Evelyn] Univ Catolica Santiago Guayaquil, Sch Med, Av Pdte Carlos Julio Arosemena Tola, Guayaquil 090615, Ecuador. [Cucalon, Gabriela] ESPOL Polytech Univ, Lifesci Fac, ESPOL, Escuela Super Politecn Litoral, Campus Gustavo Galindo Km 30-5 Via Perimetral, Guayaquil, Ecuador. [Pazderska, Agnieszka] Istanbul Univ Cerrahpasa, Cerrahpasa Med Sch, Dept Internal Med, Div Endocrinol Metab & Diabet, TR-34098 Istanbul, Turkey. [Barrea, Luigi] Univ Telemat Pegaso, Dipartimento Sci Umanist, I-80143 Naples, Italy. C3 University of Naples Federico II; University of Naples Federico II; Istanbul University - Cerrahpasa; International Hellenic University; Universidad Catolica de Santiago de Guayaquil; Escuela Superior Politecnica del Litoral; Istanbul University - Cerrahpasa; Pegaso Online University RP Muscogiuri, G (通讯作者)，Univ Federico II, Endocrinol Unit, Dipartimento Med Clin & Chirurg, Naples, Italy.; Muscogiuri, G; Barrea, L (通讯作者)，Univ Med Sch Naples, Ctr Italiano Cura & Benessere Paziente Con Obes C, Dept Clin Med & Surg, Endocrinol Unit, Naples, Italy.; Muscogiuri, G (通讯作者)，Univ Federico II, Cattedra Unesco Educ Salute & Allo Sviluppo Soste, Naples, Italy.; Barrea, L (通讯作者)，Univ Telemat Pegaso, Dipartimento Sci Umanist, I-80143 Naples, Italy. EM giovanna.muscogiuri@unina.it; luigi.barrea@unina.it RI Colao, Annamaria/A-7671-2011; Muscogiuri, Giovanna/K-5817-2016; Gutiérrez, Laura/IYJ-6582-2023; Sulu, Cem/AAW-9266-2021; Yumuk, Volkan/AAB-6871-2021; KATSIKI, NIKI/ADE-7999-2022; Frias-Toral, Evelyn/AAZ-7346-2020; Verde, Ludovica/AHB-4097-2022; Barrea, Luigi/K-6551-2016 OI KATSIKI, NIKI/0000-0003-0894-2644; Frias-Toral, Evelyn/0000-0002-2228-0141; Cucalon Ramirez, Maria Gabriela/0000-0002-6900-5649; Verde, Ludovica/0000-0002-4583-8283; Barrea, Luigi/0000-0001-9054-456X FU Universita degli Studi di Napoli Federico II within the CRUI-CARE Agreement FX Open access funding provided by Universita degli Studi di Napoli Federico II within the CRUI-CARE Agreement. 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Obes. Rep. PD DEC PY 2022 VL 11 IS 4 BP 287 EP 304 DI 10.1007/s13679-022-00481-1 EA SEP 2022 PG 18 WC Endocrinology & Metabolism; Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Endocrinology & Metabolism; Nutrition & Dietetics GA 6W5UQ UT WOS:000862187500001 PM 36178601 OA Green Submitted, hybrid HC Y HP N DA 2026-02-02 ER PT J AU Cortés, VA Fernández-Galilea, M AF Cortes, Victor A. Fernandez-Galilea, Marta TI Lipodystrophies: adipose tissue disorders with severe metabolic implications SO JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY LA English DT Review DE Lipodystrophy; Adipose tissue; Insulin resistance; Hypertriglyceridemia; Leptin; Treatment; Nutrition ID CONGENITAL GENERALIZED LIPODYSTROPHY; FAMILIAL PARTIAL LIPODYSTROPHY; ACTIVE ANTIRETROVIRAL THERAPY; REVERSES INSULIN-RESISTANCE; LEPTIN-REPLACEMENT THERAPY; OF-THE-LITERATURE; MEDITERRANEAN DIET; CLINICAL-FEATURES; DIABETES-MELLITUS; HEPATIC STEATOSIS AB Lipodystrophy encompass a group of heterogeneous disorders consisting in marked reduction, absence, and/or the redistribution of adipose tissue. Lipodystrophy is frequently complicated with severe insulin resistance, diabetes, hyperlipidemia, and fatty liver. Anatomically, lipodystrophies can be partial or generalized. Etiologically, they can be congenital or acquired. Lipodystrophy diagnosis can be challenging, and it has been suggested that partial forms can be easily misdiagnosed as common central obesity with associated metabolic syndrome. Conventional insulin-sensitizing approaches usually fail to fully ameliorate insulin resistance in lipodystrophic patients. Leptin replacement is an approved therapy for the metabolic complications of congenital generalized lipodystrophy. Novel nutritional interventions are promising complementary approaches for treating lipodystrophy metabolic complications. C1 [Cortes, Victor A.; Fernandez-Galilea, Marta] Pontificia Univ Catolica Chile, Dept Nutr Diabet & Metab, Santiago, Chile. C3 Pontificia Universidad Catolica de Chile RP Cortés, VA (通讯作者)，Pontificia Univ Catolica Chile, Dept Nutr Diabet & Metab, C Av Libertador Bernardo OHiggins 340, Santiago, Chile. EM vcortes@med.puc.cl RI ; Fernández-Galilea, Marta/AAA-2635-2019 OI Cortés, Víctor/0000-0002-1658-0965; Fernández-Galilea, Marta/0000-0002-4822-3188 CR Agarwal AK, 2002, J CLIN ENDOCR METAB, V87, P408, DOI 10.1210/jc.87.1.408 Andrés V, 2009, J CELL BIOL, V187, P945, DOI 10.1083/jcb.200904124 Asilmaz E, 2004, J CLIN INVEST, V113, P414, DOI 10.1172/JCI200419511 BERARDINELLI W, 1954, J CLIN ENDOCR METAB, V14, P193, DOI 10.1210/jcem-14-2-193 Cao H, 2000, HUM MOL GENET, V9, P109, DOI 10.1093/hmg/9.1.109 Chong AY, 2010, DIABETOLOGIA, V53, P27, DOI 10.1007/s00125-009-1502-9 Colca JR, 2004, AM J PHYSIOL-ENDOC M, V286, pE252, DOI 10.1152/ajpendo.00424.2003 Cortés VA, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0087173 Cortés VA, 2014, J LIPID RES, V55, P276, DOI 10.1194/jlr.M045799 Rocha EDD, 2010, ANN NUTR METAB, V57, P9, DOI 10.1159/000313932 Decaudain A, 2007, J CLIN ENDOCR METAB, V92, P4835, DOI 10.1210/jc.2007-0654 Domingo P, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0089088 DUNNIGAN MG, 1974, Q J MED, V43, P33 Dutour A, 2011, HUM MOL GENET, V20, P3779, DOI 10.1093/hmg/ddr294 Ebihara K, 2007, J CLIN ENDOCR METAB, V92, P532, DOI 10.1210/jc.2006-1546 Gandotra S, 2011, NEW ENGL J MED, V364, P740, DOI 10.1056/NEJMoa1007487 Garg A, 2011, J CLIN ENDOCR METAB, V96, P3313, DOI 10.1210/jc.2011-1159 Goldenberg D, 2014, REV MED CHILE, V142, P738, DOI 10.4067/S0034-98872014000600008 Halberg N, 2008, ENDOCRIN METAB CLIN, V37, P753, DOI 10.1016/j.ecl.2008.07.002 Herbst KL, 2003, DIABETES CARE, V26, P1819, DOI 10.2337/diacare.26.6.1819 ISHII J, 1989, JPN J MED, V28, P534 Javor ED, 2005, DIABETES, V54, P1994, DOI 10.2337/diabetes.54.7.1994 Javor ED, 2004, J CLIN ENDOCR METAB, V89, P3199, DOI 10.1210/jc.2003-032140 Khalife WI, 2008, TEX HEART I J, V35, P196 KOBBERLING J, 1975, HUMANGENETIK, V29, P111, DOI 10.1007/BF00430347 Levy M, 2014, SEMIN IMMUNOPATHOL, V36, P261 Maguire M, 2012, OBSTET GYNECOL, V119, P452, DOI 10.1097/AOG.0b013e31822cecf7 McDuffie JR, 2004, J CLIN ENDOCR METAB, V89, P4258, DOI 10.1210/jc.2003-031868 McNally M, 2004, AM J TRANSPLANT, V4, P447, DOI 10.1111/j.1600-6143.2004.00358.x Minokoshi Y, 2002, NATURE, V415, P339, DOI 10.1038/415339a Misra A, 2004, MEDICINE, V83, P18, DOI 10.1097/01.md.0000111061.69212.59 Misra A, 2003, MEDICINE, V82, P129, DOI 10.1097/00005792-200303000-00007 Miyamoto L, 2012, J BIOL CHEM, V287, P40441, DOI 10.1074/jbc.M112.384545 Montenegro RM Jr, 2002, J PEDIATR ENDOCR MET, V15, P441 Musso C, 2006, CLIN J AM SOC NEPHRO, V1, P616, DOI 10.2215/CJN.01271005 Naska A, 2014, NUTR METAB CARDIOVAS, V24, P216, DOI 10.1016/j.numecd.2013.11.007 Oral EA, 2002, NEW ENGL J MED, V346, P570, DOI 10.1056/NEJMoa012437 Paik JH, 2007, CELL, V128, P309, DOI 10.1016/j.cell.2006.12.029 Petersen KF, 2002, J CLIN INVEST, V109, P1345, DOI [10.1172/JCI200215001, 10.1172/JCI0215001] Rother KI, 2013, DIABETES CARE, V36, P2142, DOI 10.2337/dc13-0561 SAITO I, 1977, J AM GERIATR SOC, V25, P175, DOI 10.1111/j.1532-5415.1977.tb00288.x SEIP M, 1959, Acta Paediatr, V48, P555 Shastry S, 2010, AM J MED GENET A, V152A, P2245, DOI 10.1002/ajmg.a.33578 Shimomura I, 1999, NATURE, V401, P73, DOI 10.1038/43448 Simha V, 2008, DIABETES OBES METAB, V10, P1275, DOI 10.1111/j.1463-1326.2008.00978.x Simha V, 2003, DIABETES CARE, V26, P30, DOI 10.2337/diacare.26.1.30 Strickland LR, 2013, DIABETES CARE, V36, P2247, DOI 10.2337/dc12-1529 Subramanyam L, 2010, CLIN GENET, V78, P66, DOI 10.1111/j.1399-0004.2009.01350.x Tam CS, 2012, CIRCULATION, V125, P2782, DOI 10.1161/CIRCULATIONAHA.111.042929 Tsiodras S, 2009, METABOLISM, V58, P854, DOI 10.1016/j.metabol.2009.02.012 Turcinov D, 2009, EUR J EPIDEMIOL, V24, P267, DOI 10.1007/s10654-009-9330-2 Unger RH, 2010, TRENDS ENDOCRIN MET, V21, P345, DOI 10.1016/j.tem.2010.01.009 Ursich MJM, 1997, METABOLISM, V46, P159, DOI 10.1016/S0026-0495(97)90295-X Villarroya F, 2005, TRENDS PHARMACOL SCI, V26, P88, DOI 10.1016/j.tips.2004.12.005 Visser ME, 2011, DIABETOLOGIA, V54, P1639, DOI 10.1007/s00125-011-2142-4 Weir-Mitchell S, 1885, AM J MED SCI, V90, P105 Yano M, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0061380 NR 57 TC 29 Z9 36 U1 0 U2 12 PU SPRINGER PI DORDRECHT PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS SN 1138-7548 EI 1877-8755 J9 J PHYSIOL BIOCHEM JI J. Physiol. Biochem. PD SEP PY 2015 VL 71 IS 3 BP 471 EP 478 DI 10.1007/s13105-015-0404-1 PG 8 WC Biochemistry & Molecular Biology; Physiology WE Science Citation Index Expanded (SCI-EXPANDED) SC Biochemistry & Molecular Biology; Physiology GA CP5QK UT WOS:000359938400010 PM 25833179 DA 2026-02-02 ER PT J AU Kerr, J Anderson, C Lippman, SM AF Kerr, Jacqueline Anderson, Cheryl Lippman, Scott M. TI Physical activity, sedentary behaviour, diet, and cancer: an update and emerging new evidence SO LANCET ONCOLOGY LA English DT Article ID TELEVISION VIEWING TIME; NIH-AARP DIET; DOSE-RESPONSE METAANALYSIS; INVASIVE BREAST-CANCER; CAUSE-SPECIFIC MORTALITY; QUALITY-OF-LIFE; PROSTATE-CANCER; COLORECTAL-CANCER; MEDITERRANEAN DIET; VITAMIN-E AB The lifestyle factors of physical activity, sedentary behaviour, and diet are increasingly being studied for their associations with cancer. Physical activity is inversely associated with and sedentary behaviour is positively (and independently) associated with an increased risk of more than ten types of cancer, including colorectal cancer (and advanced adenomas), endometrial cancers, and breast cancer. The most consistent dietary risk factor for premalignant and invasive breast cancer is alcohol, whether consumed during early or late adult life, even at low levels. Epidemiological studies show that the inclusion of wholegrain, fibre, fruits, and vegetables within diets are associated with reduced cancer risk, with diet during early life (age <8 years) having the strongest apparent association with cancer incidence. However, randomised controlled trials of diet-related factors have not yet shown any conclusive associations between diet and cancer incidence. Obesity is a key contributory factor associated with cancer risk and mortality, including in dose-response associations in endometrial and post-menopausal breast cancer, and in degree and duration of fatty liver disease-related hepatocellular carcinoma. Obesity produces an inflammatory state, characterised by macrophages clustered around enlarged hypertrophied, dead, and dying adipocytes, forming crown-like structures. Increased concentrations of aromatase and interleukin 6 in inflamed breast tissue and an increased number of macrophages, compared with healthy tissue, are also observed in women with normal body mass index, suggesting a metabolic obesity state. Emerging randomised controlled trials of physical activity and dietary factors and mechanistic studies of immunity, inflammation, extracellular matrix mechanics, epigenetic or transcriptional regulation, protein translation, circadian disruption, and interactions of the multibiome with lifestyle factors will be crucial to advance this field. C1 [Kerr, Jacqueline; Anderson, Cheryl; Lippman, Scott M.] Univ Calif San Diego, Moores Canc Ctr, 3855 Hlth Sci Dr, La Jolla, CA 92093 USA. [Kerr, Jacqueline; Anderson, Cheryl] Univ Calif San Diego, Dept Family Med & Publ Hlth, La Jolla, CA 92093 USA. [Lippman, Scott M.] Univ Calif San Diego, Dept Med, La Jolla, CA 92093 USA. C3 University of California System; University of California San Diego; University of California System; University of California San Diego; University of California System; University of California San Diego RP Lippman, SM (通讯作者)，Univ Calif San Diego, Moores Canc Ctr, 3855 Hlth Sci Dr, La Jolla, CA 92093 USA. EM slippman@ucsd.edu RI KERR, JACQUELINE/H-2537-2016 FU NIH NCI [CA179977-04]; NHLBI [HL125405-03]; NIH NCI grant [P30CA023100-30] FX JK is supported in part by NIH NCI (CA179977-04) and NHLBI (HL125405-03) grants. SML is supported in part by an NIH NCI grant (P30CA023100-30). The authors thank Leona Flores for editorial assistance with this article. 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PD AUG PY 2017 VL 18 IS 8 BP E457 EP E471 DI 10.1016/S1470-2045(17)30411-4 PG 15 WC Oncology WE Science Citation Index Expanded (SCI-EXPANDED) SC Oncology GA FB7DO UT WOS:000406301500025 PM 28759385 OA Green Submitted HC Y HP N DA 2026-02-02 ER PT J AU Martínez-Beamonte, R Barranquero, C Soler, L Herrero-Continente, T Rondón, AC Arnal, C Estopañán, G Lasheras, R Rodriguez-Yoldi, MJ Surra, JC Martín-Belloso, O Odriozola-Serrano, I Osada, J Navarro, MA AF Martinez-Beamonte, Roberto Barranquero, Cristina Soler, Laura Herrero-Continente, Tania Rondon, Anny Carolina Arnal, Carmen Estopanan, Gloria Lasheras, Roberto Rodriguez-Yoldi, Maria Jesus Surra, Joaquin Carlos Martin-Belloso, Olga Odriozola-Serrano, Isabel Osada, Jesus Navarro, Maria Angeles TI Effect of Extra Virgin Olive Oil High in Bioactive Compounds on Atherosclerosis in Apoe-Deficient Mice SO MOLECULAR NUTRITION & FOOD RESEARCH LA English DT Article DE apolipoprotein E-deficient mice; atherosclerosis; EVOO; lipoproteins; squalene ID PHENOLIC-COMPOUNDS; CARDIOVASCULAR-DISEASE; MEDITERRANEAN DIET; SQUALENE; METABOLISM; RISK AB To test the effects of extra virgin olive oil (EVOO) enriched in specific bioactive compounds (EVOO HBC) on atherosclerosis and fatty liver, three isocaloric Western diets differing in the type of fat (palm, EVOO, or EVOO HBC) were fed to Apoe-deficient mice for 12 weeks. Plasma lipids, lipoprotein characterization, circulating CD36-expressing monocytes, and M2 peritoneal macrophages were quantified. Hepatic squalene and cross-sectional and en face atherosclerotic lesions were analyzed. Compared to the palm group, plasma triglyceride and glucose levels increased, while APOA1, paraoxonase 1 activity, and lipoprotein oxidation decreased in mice fed both EVOO groups. The latter stored liver squalene according to the amount consumed. En face and cross-sectional atherosclerotic lesions were lower in the EVOO groups. CD36 expression in circulating monocytes was lower and M2 peritoneal macrophages were higher in the EVOO groups. In males, there was a reduced presence of CD68-expressing cells in atherosclerotic plaques, while in females, there was a reduction in en face lesions that negatively correlated with high-density lipoprotein (HDL)-phospholipid efflux. The recruitment of macrophages into atherosclerotic plaques and the improvement of HDL efflux may be sex-dependent and attributable to the high content of squalene and a specific oleuropein aglycone. C1 [Martinez-Beamonte, Roberto; Barranquero, Cristina; Soler, Laura; Herrero-Continente, Tania; Rondon, Anny Carolina; Osada, Jesus; Navarro, Maria Angeles] Univ Zaragoza, Fac Vet, Dept Bioquim & Biol Mol & Celular, Inst Invest Sanitaria Aragon, Zaragoza, Spain. [Martinez-Beamonte, Roberto; Barranquero, Cristina; Arnal, Carmen; Rodriguez-Yoldi, Maria Jesus; Surra, Joaquin Carlos; Osada, Jesus; Navarro, Maria Angeles] Univ Zaragoza, Inst Agroalimentario Aragon, CITA, Zaragoza, Spain. [Martinez-Beamonte, Roberto; Barranquero, Cristina; Arnal, Carmen; Rodriguez-Yoldi, Maria Jesus; Surra, Joaquin Carlos; Osada, Jesus; Navarro, Maria Angeles] Inst Salud Carlos III, CIBER Fisiopatol Obes & Nutr, Madrid, Spain. [Arnal, Carmen] Univ Zaragoza, Fac Vet, Dept Patol Anim, Zaragoza, Spain. [Estopanan, Gloria] Ctr Invest & Tecnol Agroalimentaria Aragon CITA, Zaragoza, Spain. [Lasheras, Roberto] Gobierno Aragon, Serv Segur Agroalimentaria, Lab Agroambiental, Direcc Gen Alimentac & Fomento Agroalimentario, Zaragoza, Spain. [Rodriguez-Yoldi, Maria Jesus] Univ Zaragoza, Fac Vet, Dept Farmacol Fisiol Med Legal & Forense, Inst Invest Sanitaria Aragon, E-50013 Zaragoza, Spain. [Surra, Joaquin Carlos] Univ Zaragoza, Escuela Politecn Super Huesca, Dept Prod Anim & Ciencia Alimentos, Inst Invest Sanitaria Aragon, Huesca, Spain. [Martin-Belloso, Olga; Odriozola-Serrano, Isabel] Univ Lleida, Dept Food Technol Engn & Sci, Lleida, Spain. [Martin-Belloso, Olga; Odriozola-Serrano, Isabel] Agrotecnio CERCA Ctr, Lleida, Spain. C3 University of Zaragoza; University of Zaragoza; Instituto de Salud Carlos III; CIBER - Centro de Investigacion Biomedica en Red; CIBEROBN; University of Zaragoza; University of Zaragoza; University of Zaragoza; Universitat de Lleida RP Osada, J (通讯作者)，Univ Zaragoza, Fac Vet, Dept Bioquim & Biol Mol & Celular, Inst Invest Sanitaria Aragon, Zaragoza, Spain.; Osada, J (通讯作者)，Univ Zaragoza, Inst Agroalimentario Aragon, CITA, Zaragoza, Spain.; Osada, J (通讯作者)，Inst Salud Carlos III, CIBER Fisiopatol Obes & Nutr, Madrid, Spain. EM josada@unizar.es RI Oiozola-Serrano, Isabel/I-5448-2012; Martin-Belloso, Olga/ABA-4758-2022; Navarro, Ángeles/AAG-6089-2019; Barranquero, Cristina/LSM-4589-2024; Martinez-Beamonte, Roberto/E-4981-2016; Zavala-Arnal, Carmen/ABG-4701-2020 OI Oiozola-Serrano, Isabel/0000-0002-3753-0975; FU CIBEROBN [CB06/03/1012]; CIBER Fisiopatologia de la Obesidad y Nutricion; Instituto de Salud Carlos III as an initiative of FEDER-ISCIII; Ministerio de Ciencia e Innovacion [PID2022-136414OB-I00]; Spanish Ministry of Science and Innovation; European Union NextGeneration EU, from the Recovery, Transformation and Resilience Plan [PRTR-C17]; EU-PRIMA [2432]; Interreg SUDOE Programme grant under the European Union's ERDF [S1/1.1/E01116]; Fondo Social Europeo-Gobierno de Aragon [B16_23R] FX The present research was supported by grants CIBEROBN (CB06/03/1012) CIBER Fisiopatologia de la Obesidad y Nutricion, Instituto de Salud Carlos III as an initiative of FEDER-ISCIII, Ministerio de Ciencia e Innovacion (PID2022-136414OB-I00), by Spanish Ministry of Science and Innovation with funds from the European Union NextGeneration EU, from the Recovery, Transformation and Resilience Plan grant number PRTR-C17, the EU-PRIMA contract 2432 and the Interreg SUDOE Programme grant number NEWPOWER, S1/1.1/E01116, under the European Union's ERDF, which is a funding instrument designed to support the economic and social development of European regions. It was also supported by the Fondo Social Europeo-Gobierno de Aragon (B16_23R). 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Nutr. Food Res. PD NOV PY 2025 VL 69 IS 22 AR e70223 DI 10.1002/mnfr.70223 EA SEP 2025 PG 13 WC Food Science & Technology WE Science Citation Index Expanded (SCI-EXPANDED) SC Food Science & Technology GA E4801 UT WOS:001560986900001 PM 40888233 OA Green Submitted, hybrid DA 2026-02-02 ER PT J AU Dagla, I Benaki, D Baira, E Lemonakis, N Poudyal, H Brown, L Tsarbopoulos, A Skaltsounis, AL Mikros, E Gikas, E AF Dagla, Ioanna Benaki, Dimitra Baira, Eirini Lemonakis, Nikolaos Poudyal, Hemant Brown, Lindsay Tsarbopoulos, Anthony Skaltsounis, Alexios-Leandros Mikros, Emmanouel Gikas, Evagelos TI Alteration in the liver metabolome of rats with metabolic syndrome after treatment with Hydroxytyrosol. A Mass Spectrometry And Nuclear Magnetic Resonance - based metabolomics study SO TALANTA LA English DT Article DE Metabolomics; Metabolic syndrome; MS; NMR; Hydroxytyrosol ID INSULIN-RESISTANCE; LIPIDOMIC ANALYSIS; OXIDATIVE STRESS; DIET; OBESITY; NMR; IDENTIFICATION; COMPONENTS; DISCOVERY AB Metabolic syndrome (MetS) represents a group of abnormalities that enhances the risk for cardiovascular disease, diabetes and stroke. The Mediterranean diet seems to be an important dietary pattern, which reduces the incidence of MetS. Hydroxytyrosol (HT)-a simple phenol found in olive oil-has received increased attention for its antioxidant activity. Recently, the European Foods Safety Authority (EFSA) claimed that dietary consumption of HT exhibits a protective role against cardiovascular disease. In this study, an experimental protocol has been setup, including isolated HT administration in a diet induced model of MetS in young Wistar rats, in order to find out whether HT has a protective effect against MetS. Rats were randomly divided into two groups nurtured by high-carbohydrate high-fat (H) (MetS inducing diet) and high-carbohydrate high-fat + HT (HHT). HT (20 mg/ kg/d oral gavage, water vehicle) was administered for 8 weeks on the basal diet. Previous pharmacological evaluation of HT showed that hepatic steatosis was reduced and the inflammatory cells into the liver were infiltrated. These indicate that HT shows bioactivity against metabolic syndrome. Therefore, the metabolomics evaluation of liver extracts would indicate the putative biochemical mechanisms of HT activity. Thus, the extracts of liver tissues were analyzed using Ultra Performance Liquid Chromatography High Resolution Mass Spectrometry (UPLC-HRMS, Orbitrap Discovery) and. Nuclear Magnetic Resonance (NMR) spectroscopy (Broker Avance III 600 MHz). Multivariate analysis was performed in order to gain insight on the metabolic effects of HT administration on the liver metabolome. Normalization employing multiple internal standards and Quality Control based Robust LOESS (Locally Estimated Scatterplot Smoothing) Signal Correction algorithm (QC-RLSC) was added in the processing pipeline to enhance the reliability of metabolomic analysis by reducing unwanted information. Experimentally, HHT rats were clearly distinguished from H in PLS-DA, showing differences in the liver metabolome between the groups and specific biomarkers were determined supporting the pharmacological findings. More specifically, HT has shown to be effective towards the mobilization of lipids as various lipid classes being differentially regulated between the H and HHT groups. Interestingly branched fatty acid esters of hydroxy oleic acids (OAHSA) lipids have been shown to be up regulated to the HHT group, denoting the alleviation of the MetS to the animals administered with HT. C1 [Dagla, Ioanna; Benaki, Dimitra; Baira, Eirini; Mikros, Emmanouel; Gikas, Evagelos] Univ Athens, Sch Hlth Sci, Div Pharmaceut Chem, Lab Pharmaceut Anal,Fac Pharm, Athens 15771, Greece. [Lemonakis, Nikolaos; Skaltsounis, Alexios-Leandros] Univ Athens, Sch Hlth Sci, Div Pharmacognosy & Nat Prod Chem, Fac Pharm, Athens 15771, Greece. [Poudyal, Hemant] Kyoto Univ, Dept Diabet Endocrinol & Nutr, Hakubi Ctr Adv Res, Kyoto, Japan. [Brown, Lindsay] Univ Southern Queensland, Sch Hlth & Wellbeing, Toowoomba, Qld 4350, Australia. [Tsarbopoulos, Anthony] Univ Athens, Dept Descript Funct Studies, Lab Pharmacol, Fac Med, Athens, Greece. C3 National & Kapodistrian University of Athens; National & Kapodistrian University of Athens; Kyoto University; University of Southern Queensland; National & Kapodistrian University of Athens RP Mikros, E; Gikas, E (通讯作者)，Univ Athens, Sch Hlth Sci, Div Pharmaceut Chem, Lab Pharmaceut Anal,Fac Pharm, Athens 15771, Greece. 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Regoli, F. TI Could molecular effects of Caulerpa racemosa metabolites modulate the impact on fish populations of Diplodus sargus? SO MARINE ENVIRONMENTAL RESEARCH LA English DT Article DE Biological invasions; Caulerpa racemosa; Biomarkers; Molecular effects; Diplodus sargus ID MYTILUS-GALLOPROVINCIALIS; MEDITERRANEAN SEA; TREMATOMUS-BERNACCHII; BIOLOGICAL INVASIONS; REPRODUCTIVE-BIOLOGY; LIPID-PEROXIDATION; INDOLE ALKALOIDS; VAR. CYLINDRACEA; ACETYLCHOLINESTERASE; ANTIOXIDANT AB The green alga Caulerim racemosa is a non-native, invasive species in the Mediterranean, and an important stressor for several native organisms. The algal capacity to produce secondary metabolites has been suggested to modulate success of the C racemosa invasion, although many of potentially involved biological pathways still remain unexplored. In this respect, the aim of the present study was to investigate some molecular and cellular effects in the white seabream Diplodus sargus, an ecologically key species, which included the alien C racemosa in its diet. Organisms were sampled in 2 seasonal periods from 3 locations of Southern Italy, each characterized by different levels of algal abundance. The level of caulerpin, one of the main secondary algal metabolites, in fish tissues has been used as an indicator of the trophic exposure to the seaweed and related with molecular and cellular responses. Chemical analyses indicated that fish from invaded sites can accumulate caulerpin, with liver concentrations ranging from a few up to hundreds of mu g/g. Biomarkers analyses revealed only limited alterations of the main antioxidant defences, such as glutathione reductase and levels of glutathione; on the other hand, increased enzymatic activities of cytochrome P450, glutathione S-transferases and acyl CoA oxidase, as well as enhanced gene transcription for peroxisome proliferator-activated receptor alpha, cytochrome P4501A and vitellogenin 1 were observed in fish more exposed to C racemosa as indicated by liver concentrations of caulerpin higher than 50 mu g/g. Despite a direct molecular relationship with this algal metabolite could not be established, our results suggest that a C. racemosa enriched diet can modulate biotransformation and fatty acids metabolism of D. sargus. Assessing whether similar effects represent short- or long-term effects will be of crucial importance to understand consequences on the general health status and reproductive performance of exposed key fish species in the Mediterranean region. (C) 2014 Elsevier Ltd. All rights reserved. C1 [Gorbi, S.; Giuliani, M. E.; Pittura, L.; d'Errico, G.; Regoli, F.] Univ Politecn Marche, Dipartimento Sci Vita & Ambiente, I-60131 Ancona, Italy. [Terlizzi, A.; Felline, S.; Grauso, L.] Univ Salento, Dipartimento Sci & Tecnol Biol & Ambientali, Lecce, Italy. [Mollo, E.; Cutignano, A.] CNR, Ist Chim Biomol, I-80125 Naples, Italy. C3 Marche Polytechnic University; University of Salento; Consiglio Nazionale delle Ricerche (CNR); Istituto di Chimica Biomolecolare (ICB-CNR) RP Gorbi, S (通讯作者)，Univ Politecn Marche, Dipartimento Sci Vita & Ambiente, Via Brecce Bianche, I-60131 Ancona, Italy. EM s.gorbi@univpm.it RI Pittura, Lucia/GZG-9838-2022; Mollo, Ernesto/F-7842-2013; Grauso, Laura/C-2374-2011; Giuliani, Maria Elisa/K-5369-2016; Terlizzi, Antonio/B-6131-2015; Cutignano, Adele/C-3343-2012; gorbi, stefania/K-5662-2016; Regoli, Francesco/K-2719-2018 OI Pittura, Lucia/0000-0001-7508-469X; d'Errico, Giuseppe/0000-0003-1667-8038; Mollo, Ernesto/0000-0001-7379-1788; Grauso, Laura/0000-0001-9165-8796; Giuliani, Maria Elisa/0000-0002-7487-5171; Terlizzi, Antonio/0000-0001-5968-4548; Cutignano, Adele/0000-0003-3035-9252; gorbi, stefania/0000-0002-4232-2652; Regoli, Francesco/0000-0001-6084-6188; Felline, Serena/0000-0003-1221-7306 FU MIUR (The Ministry of Education, Universities and Research) (PRIN); EU FP7 PERSEUS Project [287600]; MIUR (The Ministry of Education, Universities and Research) (CAUDIP); MIUR (The Ministry of Education, Universities and Research) (PRIN CAULERFISH) FX Financial support was provided by MIUR (The Ministry of Education, Universities and Research) (PRIN 2009, CAUDIP and PRIN 2012 CAULERFISH), and by the EU FP7 PERSEUS Project (Grant Agreement No. 287600). C. Vaglio and P. Patarnello provided invaluable assistance during sampling operations. 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Environ. Res. PD MAY PY 2014 VL 96 SI SI BP 2 EP 11 DI 10.1016/j.marenvres.2014.01.010 PG 10 WC Environmental Sciences; Marine & Freshwater Biology; Toxicology WE Science Citation Index Expanded (SCI-EXPANDED) SC Environmental Sciences & Ecology; Marine & Freshwater Biology; Toxicology GA AF8QV UT WOS:000334981600002 PM 24582326 OA Green Submitted DA 2026-02-02 ER PT J AU Gepner, Y Shelef, I Komy, O Cohen, N Schwarzfuchs, D Bril, N Rein, M Serfaty, D Kenigsbuch, S Zelicha, H Meir, AY Tene, L Bilitzky, A Tsaban, G Chassidim, Y Sarusy, B Ceglarek, U Thiery, J Stumvoll, M Blüher, M Stampfer, MJ Rudich, A Shai, I AF Gepner, Yftach Shelef, Ilan Komy, Oded Cohen, Noa Schwarzfuchs, Dan Bril, Nitzan Rein, Michal Serfaty, Dana Kenigsbuch, Shira Zelicha, Hila Meir, Anat Yaskolka Tene, Lilac Bilitzky, Avital Tsaban, Gal Chassidim, Yoash Sarusy, Benjamin Ceglarek, Uta Thiery, Joachim Stumvoll, Michael Blueher, Matthias Stampfer, Meir J. Rudich, Assaf Shai, Iris TI The beneficial effects of Mediterranean diet over low-fat diet may be mediated by decreasing hepatic fat content SO JOURNAL OF HEPATOLOGY LA English DT Article DE Hepatic fat content; Visceral adipose tissue; Diet; Lifestyle; Clinical trial; Low carbohydrate; Cardiovascular risk; NAFLD ID GAMMA-GLUTAMYL-TRANSPEPTIDASE; WEIGHT-LOSS; LIVER-DISEASE; LOW-CARBOHYDRATE; CARDIOVASCULAR RISK; GLUCOSE-TOLERANCE; AMERICAN-COLLEGE; ADIPOSE-TISSUE; STEATOSIS; OBESITY AB Background & Aim: It is unclear if a reduction in hepatic fat content (HFC) is a major mediator of the cardiometabolic benefit of lifestyle intervention, and whether it has prognostic significance beyond the loss of visceral adipose tissue (VAT). In the present sub-study, we hypothesized that HFC loss in response to dietary interventions induces specific beneficial effects independently of VAT changes. Methods: In an 18-month weight-loss trial, 278 participants with abdominal obesity/dyslipidemia were randomized to low-fat (LF) or Mediterranean/low-carbohydrate (MED/LC + 28 g walnuts/day) diets with/without moderate physical activity. HFC and abdominal fat-depots were measured using magnetic resonance imaging at baseline, after 6 (sub-study, n = 158) and 18 months. Results: Of 278 participants (mean HFC 10.2% [range: 0.01%-50.4%]), the retention rate was 86.3%. The %HFC substantially decreased after 6 months (-6.6% absolute units [ -41% relatively]) and 18 months (-4.0% absolute units [ -29% relatively]; p <0.001 vs. baseline). Reductions of HFC were associated with decreases in VAT beyond weight loss. After controlling for VAT loss, decreased %HFC remained independently associated with reductions in serum gamma glutamyltransferase and alanine aminotransferase, circulating chemerin, and glycated hemoglobin (p <0.05). While the reduction in HFC was similar between physical activity groups, MED/LC induced a greater %HFC decrease (p = 0.036) and greater improvements in cardiometabolic risk parameters (p <0.05) than the LF diet, even after controlling for VAT changes. Yet, the greater improvements in cardiometabolic risk parameters induced by MED/LC were all markedly attenuated when controlling for HFC changes. Conclusions: %HFC is substantially reduced by diet-induced moderate weight loss and is more effectively reduced by the MED/LC diet than the LF diet, independently of VAT changes. The beneficial effects of the MED/LC diet on specific cardiometabolic parameters appear to be mediated more by decreases in %HFC than VAT loss. Lay summary: High hepatic fat content is associated with metabolic syndrome, type 2 diabetes mellitus, and coronary heart disease. In the CENTRAL 18-month intervention trial, a Mediterranean/low-carbohydrate diet induced a greater decrease in hepatic fat content than a low-fat diet, conferring beneficial health effects that were beyond the favorable effects of visceral fat loss. (C) 2019 European Association for the Study of the Liver. Published by Elsevier B.V. C1 [Gepner, Yftach; Komy, Oded; Cohen, Noa; Bril, Nitzan; Rein, Michal; Serfaty, Dana; Kenigsbuch, Shira; Zelicha, Hila; Meir, Anat Yaskolka; Tene, Lilac; Bilitzky, Avital; Tsaban, Gal; Rudich, Assaf; Shai, Iris] Ben Gurion Univ Negev, Fac Hlth Sci, Beer Sheva, Israel. [Gepner, Yftach] Tel Aviv Univ, Sackler Fac Med & Sylvan Adams Sports Inst, Sch Publ Hlth, Dept Epidemiol & Prevent Med, Tel Aviv, Israel. [Shelef, Ilan; Schwarzfuchs, Dan; Chassidim, Yoash] Soroka Univ Med Ctr, Beer Sheva, Israel. [Schwarzfuchs, Dan; Sarusy, Benjamin] Nucl Res Ctr Negev, Dimona, Israel. [Ceglarek, Uta; Thiery, Joachim; Stumvoll, Michael; Blueher, Matthias] Univ Leipzig, Dept Med, Leipzig, Germany. [Stampfer, Meir J.] Brigham & Womens Hosp, Dept Med, Channing Div Network Med, 75 Francis St, Boston, MA 02115 USA. [Stampfer, Meir J.] Harvard Sch Publ Hlth, Boston, MA USA. C3 Ben-Gurion University of the Negev; Tel Aviv University; Ben-Gurion University of the Negev; Soroka Medical Center; Leipzig University; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard University; Harvard T.H. Chan School of Public Health RP Shai, I (通讯作者)，Ben Gurion Univ Negev, Fac Hlth Sci, Dept Publ Hlth, S Daniel Abraham Int Ctr Hlth & Nutr, POB 653, IL-84105 Beer Sheva, Israel. EM irish@bgu.ac.il RI Rudich, Assaf/MSY-8816-2025; Stumvoll, Michael/ABE-1121-2021; Bilitzky Kopit, Avital/KDN-5276-2024; Ceglarek, Uta/GOE-5561-2022; Shai, Iris/HJO-8533-2023; Meir, Anat/AAK-7469-2021 OI Rudich, Assaf/0000-0002-1366-1444; Zelicha, Hila/0000-0001-6989-2332; Stumvoll, Michael/0000-0001-6225-8240; Shai, Iris/0000-0001-9050-4605; FU Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) [209933838 - SFB 1052]; Israel Ministry of Science and Technology [3-13604]; Dr. Robert C. and Veronica Atkins Research Foundation; Israel Science Foundation (ISF) FX ' This work was supported by grants from: The Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) - Projektnummer 209933838 - SFB 1052. The Israel Science Foundation (ISF), Israel Ministry of Science and Technology (grant #3-13604), and the Dr. Robert C. and Veronica Atkins Research Foundation. The foundations were not involved in any stage of the design, conduct, or analysis of the study and had no access to the study results before publication. 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The dramatic rise in infant immune diseases, most notably allergy, indicates the specific vulnerability of the immune system to early environmental changes. The associated parallel rise in metabolic diseases including obesity, childhood type 2-diabetes and non-alcoholic fatty liver disease highlights the interplay between modern dietary patterns and increasing abnormalities of both immune and metabolic health. The low-grade inflammation that characterize these non-communicable diseases (NCDs) suggests a central role of the immune system in the pathogenesis of these conditions. Understanding how environmental influences disrupt the finely balanced development of immune and metabolic programing is of critical importance. Diet-sensitive pathways are likely to be crucial in these processes. While epigenetic mechanism provides a strong explanation of how nutritional exposures can affect the fetal gene expression and subsequent disease risk, other diet-induced tissue compositional changes may also contribute directly to altered immune and metabolic function. Although modern dietary changes are complex and involve changing patterns of many nutrients, there is also interest in the developmental effects of specific nutrients such as folic acid levels, which have clear epigenetic effects on programming. Here we examine the current knowledge of the nutritional-programming of immune health and how research into nutritional-epigenetics in the context of allergic disease as one of the earliest onset NCDs can expand our knowledge to discover the biological processes sensitive to nutritional exposures in early life to prevent later disease risk. C1 [Amarasekera, Manori; Prescott, Susan L.; Palmer, Debra J.] Univ Western Australia, Sch Paediat & Child Hlth, Subiaco, WA 6008, Australia. C3 University of Western Australia RP Palmer, DJ (通讯作者)，Univ Western Australia, Sch Paediat & Child Hlth, Roberts Rd, Subiaco, WA 6008, Australia. EM debbie.palmer@uwa.edu.au RI Prescott, Susan/H-5665-2014; Palmer, Debra/AAH-6160-2019 OI Palmer, Debra/0000-0003-2498-8343 FU ALK Abello FX Prof. Susan Prescott is on the advisory Boards of Danone and the Nestle Nutrition Institute and has received speaker's fees from these organisations and from ALK Abello. None of these is relevant to this article. 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J. Allergy Immunol. PD SEP PY 2013 VL 31 IS 3 SI SI BP 175 EP 182 PG 8 WC Allergy; Immunology WE Science Citation Index Expanded (SCI-EXPANDED) SC Allergy; Immunology GA 228OS UT WOS:000325196700002 PM 24053699 DA 2026-02-02 ER PT J AU Fernando, WMADB Martins, IJ Goozee, KG Brennan, CS Jayasena, V Martins, RN AF Fernando, W. M. A. D. B. Martins, Ian J. Goozee, K. G. Brennan, Charles S. Jayasena, V. Martins, R. N. TI The role of dietary coconut for the prevention and treatment of Alzheimer's disease: potential mechanisms of action SO BRITISH JOURNAL OF NUTRITION LA English DT Review DE Coconut; Saturated fat; Amyloid; Alzheimer's; Diabetes ID MEDIUM-CHAIN TRIGLYCERIDE; CONJUGATED LINOLEIC-ACID; DUAL-TRACER PET; KETOGENIC DIET; AMYLOID-BETA; FATTY-ACIDS; BODY-FAT; ENERGY-EXPENDITURE; MEDITERRANEAN DIET; INSULIN-RESISTANCE AB Coconut, Cocos nucifera L., is a tree that is cultivated to provide a large number of products, although it is mainly grown for its nutritional and medicinal values. Coconut oil, derived from the coconut fruit, has been recognised historically as containing high levels of saturated fat; however, closer scrutiny suggests that coconut should be regarded more favourably. Unlike most other dietary fats that are high in long-chain fatty acids, coconut oil comprises medium-chain fatty acids (MCFA). MCFA are unique in that they are easily absorbed and metabolised by the liver, and can be converted to ketones. Ketone bodies are an important alternative energy source in the brain, and may be beneficial to people developing or already with memory impairment, as in Alzheimer's disease (AD). Coconut is classified as a highly nutritious 'functional food'. It is rich in dietary fibre, vitamins and minerals; however, notably, evidence is mounting to support the concept that coconut may be beneficial in the treatment of obesity, dyslipidaemia, elevated LDL, insulin resistance and hypertension - these are the risk factors for CVD and type 2 diabetes, and also for AD. In addition, phenolic compounds and hormones (cytokinins) found in coconut may assist in preventing the aggregation of amyloid-beta peptide, potentially inhibiting a key step in the pathogenesis of AD. The purpose of the present review was to explore the literature related to coconut, outlining the known mechanistic physiology, and to discuss the potential role of coconut supplementation as a therapeutic option in the prevention and management of AD. C1 [Fernando, W. M. A. D. B.; Martins, Ian J.; Goozee, K. G.; Martins, R. N.] Edith Cowan Univ, Sch Med Sci, Ctr Excellence Alzheimers Dis Res & Care, Joondalup, WA 6027, Australia. [Fernando, W. M. A. D. B.; Martins, Ian J.; Goozee, K. G.; Martins, R. N.] McCusker Alzheimers Res Fdn, Hollywood Med Ctr, Nedlands, WA 6009, Australia. [Goozee, K. G.; Martins, R. N.] Univ Western Australia, Sch Psychiat & Clin Neurosci, Nedlands, WA 6009, Australia. [Goozee, K. G.; Martins, R. N.] ARV, McCusker KARVIAH Res Ctr, Taren Point, NSW 2229, Australia. [Brennan, Charles S.] Lincoln Univ, Ctr Food Res & Innovat, Dept Wine Food & Mol Biosci, Lincoln, New Zealand. [Jayasena, V.] Curtin Univ, Sch Publ Hlth, Dept Nutr Dietet & Food Technol, Bentley, WA, Australia. C3 Edith Cowan University; University of Western Australia; Lincoln University - New Zealand; Curtin University RP Martins, RN (通讯作者)，Edith Cowan Univ, Sch Med Sci, Ctr Excellence Alzheimers Dis Res & Care, 270 Joondalup Dr, Joondalup, WA 6027, Australia. EM r.martins@ecu.edu.au RI ; Brennan, Charles/AAG-5494-2021 OI Jayasena, Vijay/0000-0001-8681-0626; Martins, Ralph/0000-0002-4828-9363; Fernando, Warnakulasuriya/0000-0002-8364-7808; Brennan, Charles/0000-0003-2479-8478; Goozee, Kathryn/0000-0002-3573-1554 FU McCusker Alzheimer's Research Foundation; Edith Cowan University; CSIRO for the AIBL (The Australian Imaging, Biomarkers and Lifestyle); Anglican Retirement Villages; Foundation for Aged Care; CRC-Mental Health Limited FX The authors gratefully acknowledge the support from the McCusker Alzheimer's Research Foundation and Edith Cowan University. W. M. A. D. B. F. is supported by the McCusker Alzheimer's Research Foundation and a grant from the CSIRO for the AIBL (The Australian Imaging, Biomarkers and Lifestyle) study. K. G. G. is supported by a grant from the Anglican Retirement Villages, Foundation for Aged Care and a grant from the CRC-Mental Health Limited. All authors contributed to the literature search, analysis of the data published, manuscript writing and revisions of the article. The authors declare no conflicts of interest arising from the conclusions of this research. 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J. Nutr. PD JUL 14 PY 2015 VL 114 IS 1 BP 1 EP 14 DI 10.1017/S0007114515001452 PG 14 WC Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Nutrition & Dietetics GA CN2YG UT WOS:000358288600001 PM 25997382 OA Green Submitted, Bronze DA 2026-02-02 ER PT J AU Smith, LA O'Flanagan, CH Bowers, LW Allott, EH Hursting, SD AF Smith, Laura A. O'Flanagan, Ciara H. Bowers, Laura W. Allott, Emma H. Hursting, Stephen D. TI Translating Mechanism-Based Strategies to Break the Obesity-Cancer Link: A Narrative Review SO JOURNAL OF THE ACADEMY OF NUTRITION AND DIETETICS LA English DT Review DE Calorie restriction; Cancer; Ketogenic diet; Obesity; Risk biomarkers ID FATTY LIVER-DISEASE; INTERMITTENT ENERGY RESTRICTION; BODY-MASS INDEX; WEIGHT-LOSS; CALORIC RESTRICTION; RANDOMIZED-TRIAL; DIETARY PATTERN; MEDITERRANEAN DIET; GLUCOSE-TOLERANCE; LOW-CARBOHYDRATE AB Prevalence of obesity, an established risk factor for many cancers, has increased dramatically over the past 50 years in the United States and across the globe. Relative to normoweight cancer patients, obese cancer patients often have poorer prognoses, resistance to chemotherapies, and are more likely to develop distant metastases. Recent progress on elucidating the mechanisms underlying the obesity-cancer connection suggests that obesity exerts pleomorphic effects on pathways related to tumor development and progression and, thus, there are multiple opportunities for primary prevention and treatment of obesity-related cancers. Obesity-associated alterations, including systemic metabolism, adipose inflammation, growth factor signaling, and angiogenesis, are emerging as primary drivers of obesity-associated cancer development and progression. These obesity-associated host factors interact with the intrinsic molecular characteristics of cancer cells, facilitating several of the hallmarks of cancer. Each is considered in the context of potential preventive and therapeutic strategies to reduce the burden of obesity-related cancers. In addition, this review focuses on emerging mechanisms behind the obesity-cancer link, as well as relevant dietary interventions, including calorie restriction, intermittent fasting, low-fat diet, and ketogenic diet, that are being implemented in preclinical and clinical trials, with the ultimate goal of reducing incidence and progression of obesity-related cancers. C1 [Smith, Laura A.; O'Flanagan, Ciara H.; Bowers, Laura W.; Allott, Emma H.; Hursting, Stephen D.] Univ N Carolina, Dept Nutr, 135 Dauer Dr,McGavran Greenberg Hall, Chapel Hill, NC 27599 USA. C3 University of North Carolina; University of North Carolina Chapel Hill RP Hursting, SD (通讯作者)，Univ N Carolina, Dept Nutr, 135 Dauer Dr,McGavran Greenberg Hall, Chapel Hill, NC 27599 USA. EM hursting@email.unc.edu OI Allott, Emma/0000-0003-1227-3615 FU Breast Cancer Research Foundation [BCRF 16-075]; National Cancer Institute/National Institutes of Health [R35 CA197627]; Marilyn Gentry Fellowship from the American Institute for Cancer Research; Cancer Control Education Program at the University of North Carolina Lineberger Comprehensive Cancer Center [R25 CA057726]; National Cancer Institute [R35CA197627, T32CA057726] Funding Source: NIH RePORTER; National Institute of Diabetes and Digestive and Kidney Diseases [P30DK056350] Funding Source: NIH RePORTER FX Stephen D. Hursting is supported by grants from the Breast Cancer Research Foundation (BCRF 16-075, Stephen D. Hursting as Principal Investigator) and National Cancer Institute/National Institutes of Health (R35 CA197627; Stephen D. Hursting as Principal Investigator). Emma H. Allott is funded by a Marilyn Gentry Fellowship from the American Institute for Cancer Research. Laura W. Bowers is supported by a postdoctoral fellowship from the Cancer Control Education Program (R25 CA057726) at the University of North Carolina Lineberger Comprehensive Cancer Center. 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Acad. Nutr. Diet. PD APR PY 2018 VL 118 IS 4 BP 652 EP 667 DI 10.1016/j.jand.2017.08.112 PG 16 WC Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Nutrition & Dietetics GA GA3XF UT WOS:000428262900012 PM 29102513 OA Green Submitted DA 2026-02-02 ER PT J AU Noto, D Fayer, F Cefalù, AB Altieri, I Palesano, O Spina, R Valenti, V Pitrone, M Pizzolanti, G Barbagallo, CM Giordano, C Averna, MR AF Noto, Davide Fayer, Francesca Cefalu, Angelo B. Altieri, Ida Palesano, Ornella Spina, Rossella Valenti, Vincenza Pitrone, Maria Pizzolanti, Giuseppe Barbagallo, Carlo M. Giordano, Carla Averna, Maurizio R. TI Myristic acid is associated to low plasma HDL cholesterol levels in a Mediterranean population and increases HDL catabolism by enhancing HDL particles trapping to cell surface proteoglycans in a liver hepatoma cell model SO ATHEROSCLEROSIS LA English DT Article DE Fatty acids; Population study; HDL cholesterol levels; HepG2 cells ID POLYUNSATURATED FATTY-ACIDS; LOW-DENSITY LIPOPROTEINS; CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; HEPG2 CELLS; LIPIDS; EXPRESSION; LIPASE; ELEMENT; MEN AB Background: HDL-C plasma levels are modulated by dietary fatty acid (FA), but studies investigating dietary supplementation in FA gave contrasting results. Saturated FA increased HDL-C levels only in some studies. Mono-unsaturated FA exerted a slight effect while poly-unsaturated FA mostly increased plasma HDL-C. Aims: This study presents two aims: i) to investigate the relationship between HDL-C levels and plasma FA composition in a Sicilian population following a "Mediterranean diet", ii) to investigate if FA that resulted correlated with plasma HDL-C levels in the population study and/or very abundant in the plasma were able to affect HDL catabolism in an "in vitro" model of cultured hepatoma cells (HepG2). Results: plasma HDL-C levels in the population correlated negatively with myristic acid (C14: 0, beta = -0.24, p < 0.01), oleic acid (C18: 1n9, beta = -0.22, p < 0.01) and cis-11-Eicosenoic (C20: 1n9, beta = -0.19, p = 0.01) and positively with palmitoleic acid (C16: 1, beta = +0.19, p = 0.03). HepG2 cells were conditioned with FA before evaluating HDL binding kinetics, and only C14: 0 increased HDL binding by a nonsaturable pathway. After removal of heparan sulphate proteoglycans (HSPG) by heparinases HDL binding dropped by 29% only in C14: 0 conditioned cells (p < 0.05). C14: 0 showed also the highest internalization of HDL-derived cholesteryl esters (CE, +32% p = 0.01 vs. non-conditioned cells). Conclusions: C14: 0 was correlated with decreased plasma HDL-C levels in a Mediterranean population. C14: 0 might reduce HDL-C levels by increasing HDL trapping to cell surface HSPG and CE stripping from bound HDL. Other mechanisms are to be investigated to explain the effects of other FA on HDL metabolism. (C) 2015 Elsevier Ireland Ltd. All rights reserved. C1 [Noto, Davide; Fayer, Francesca; Cefalu, Angelo B.; Altieri, Ida; Palesano, Ornella; Spina, Rossella; Valenti, Vincenza; Pitrone, Maria; Pizzolanti, Giuseppe; Barbagallo, Carlo M.; Giordano, Carla; Averna, Maurizio R.] Univ Palermo, Dept Biomed Internal Med & Med Specialties DIBIMI, Palermo, Italy. C3 University of Palermo RP Averna, MR (通讯作者)，Policlin Paolo Giaccone, Dept Internal Med, Via Vespro 141, I-90127 Palermo, Italy. EM avernam@mbox.unipa.it RI Cefalu', Angelo Baldassare/K-9491-2016; GIORDANO, Carla/R-4296-2017; Averna, Maurizio/U-9527-2017; Pizzolanti, Giuseppe/I-4547-2019; Noto, Davide/AAA-9208-2019 OI Cefalu', Angelo Baldassare/0000-0003-1259-8284; Averna, Maurizio/0000-0003-3558-9209; Pizzolanti, Giuseppe/0000-0001-6052-8438; Noto, Davide/0000-0002-5346-2829 CR Barbagallo CM, 2002, J AM COLL NUTR, V21, P523, DOI 10.1080/07315724.2002.10719250 Bérard AM, 2004, EUR J CLIN NUTR, V58, P881, DOI 10.1038/sj.ejcn.1601890 Botma GJ, 2005, ATHEROSCLEROSIS, V179, P61, DOI 10.1016/j.atherosclerosis.2004.10.027 BROUSSEAU ME, 1995, J NUTR, V125, P425 Camejo G, 1998, ATHEROSCLEROSIS, V139, P205, DOI 10.1016/S0021-9150(98)00107-5 Cefalù AB, 2009, ATHEROSCLEROSIS, V204, P202, DOI 10.1016/j.atherosclerosis.2008.08.031 Dreon DM, 1998, AM J CLIN NUTR, V67, P828, DOI 10.1093/ajcn/67.5.828 GIRON MD, 1992, ARCH INT PHYSIOL BIO, V100, P321, DOI 10.3109/13813459209000719 Huff MW, 1997, J LIPID RES, V38, P1318 Hunter JE, 2010, AM J CLIN NUTR, V91, P46, DOI 10.3945/ajcn.2009.27661 KELLER H, 1993, P NATL ACAD SCI USA, V90, P2160, DOI 10.1073/pnas.90.6.2160 LAGROST L, 1994, BBA-LIPID LIPID MET, V1215, P209, DOI 10.1016/0005-2760(94)90047-7 LEPAGE G, 1988, J LIPID RES, V29, P227 Loison C, 2002, BRIT J NUTR, V87, P199, DOI 10.1079/BJN2002521 Malerod L, 2003, BIOCHEM BIOPH RES CO, V305, P557, DOI 10.1016/S0006-291X(03)00819-2 MATTSON FH, 1985, J LIPID RES, V26, P194 Mayneris-Perxachs J, 2014, CLIN NUTR, V33, P90, DOI 10.1016/j.clnu.2013.03.001 Mensink RP, 2003, AM J CLIN NUTR, V77, P1146, DOI 10.1093/ajcn/77.5.1146 Michas G, 2014, ATHEROSCLEROSIS, V234, P320, DOI 10.1016/j.atherosclerosis.2014.03.013 Michaud SE, 2001, DIABETES, V50, P660, DOI 10.2337/diabetes.50.3.660 Noto D, 2008, ATHEROSCLEROSIS, V197, P147, DOI 10.1016/j.atherosclerosis.2007.03.005 Noto D, 2006, METABOLISM, V55, P1308, DOI 10.1016/j.metabol.2006.05.015 Ordovas JM, 2002, AM J CLIN NUTR, V75, P38, DOI 10.1093/ajcn/75.1.38 Sheril A, 2009, ATHEROSCLEROSIS, V204, P136, DOI 10.1016/j.atherosclerosis.2008.08.021 THOLSTRUP T, 1994, AM J CLIN NUTR, V59, P371, DOI 10.1093/ajcn/59.2.371 THOLSTRUP T, 1995, J LIPID RES, V36, P1447 Uehara Y, 2007, ATHEROSCLEROSIS, V191, P11, DOI 10.1016/j.atherosclerosis.2006.04.018 von Eckardstein A, 2005, CURR OPIN CLIN NUTR, V8, P147, DOI 10.1097/00075197-200503000-00007 Yao HR, 2011, AM J TRANSL RES, V3, P284 NR 29 TC 16 Z9 20 U1 0 U2 13 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0021-9150 EI 1879-1484 J9 ATHEROSCLEROSIS JI Atherosclerosis PD MAR PY 2016 VL 246 BP 50 EP 56 DI 10.1016/j.atherosclerosis.2015.12.036 PG 7 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease WE Science Citation Index Expanded (SCI-EXPANDED) SC Cardiovascular System & Cardiology GA DE3NY UT WOS:000370538200008 PM 26756970 OA Green Submitted, Bronze DA 2026-02-02 ER PT J AU Priore, P Siculella, L Gnoni, GV AF Priore, Paola Siculella, Luisa Gnoni, Gabriele Vincenzo TI Extra virgin olive oil phenols down-regulate lipid synthesis in primary-cultured rat-hepatocytes SO JOURNAL OF NUTRITIONAL BIOCHEMISTRY LA English DT Article DE Acetyl-CoA carboxylase; AMP-activated protein kinase; Extra virgin olive oil; Lipid synthesis; Phenols; Rat-hepatocytes ID ACTIVATED PROTEIN-KINASE; POLYUNSATURATED FATTY-ACIDS; VASCULAR ENDOTHELIAL-CELLS; MEDITERRANEAN DIET; TRIACYLGLYCEROL SYNTHESIS; ANTIOXIDANT ACTIVITIES; METABOLIC SYNDROME; OLEIC-ACID; HYDROXYTYROSOL; POLYPHENOLS AB Hydroxytyrosol, tyrosol, and oleuropein, the main phenols present in extra virgin olive oil, have been reported to exert several biochemical and pharmacological effects. Here, we investigated the short-term effects of these compounds on lipid synthesis in primary-cultured rat-liver cells. Hydroxytyrosol, tyrosol and oleuropein inhibited both de novo fatty acid and cholesterol syntheses without an effect on cell viability. The inhibitory effect of individual compounds was already evident within 2 h of 25 mu M phenol addition to the hepatocytes. The degree of cholesterogenesis reduction was similar for all phenol treatments (-25/30%), while fatty acid synthesis showed the following order of inhibition: hydroxytyrosol (-49%) = oleuropein (-48%) > tyrosol (-30%). A phenol-induced reduction of triglyceride synthesis was also detected. To clarify the lipid-lowering mechanism of these compounds, their influence on the activity of key enzymes of fatty acid biosynthesis (acetyl-CoA carboxylase and fatty acid synthase), triglyceride synthesis (diacylglycerol acyltransferase) and cholesterogenesis (3-hydroxy-3-methyl-glutaryl-00A reductase) was investigated in situ by using digitonin-permeabilized hepatocytes. Acetyl-CoA carboxylase, diacylglycerol acyltransferase and 3-hydroxy-3-methyl-glutaryl-00A reductase activities were reduced after 2 h of 25 mu M phenol treatment. No change in fatty acid synthase activity was observed. Acetyl-CoA carboxylase inhibition (hydroxytyrosol, -41%, = oleuropein, -38%, > tyrosol, -17%) appears to be mediated by phosphorylation of AMP-activated protein kinase. These findings suggest that a decrease in hepatic lipid synthesis may represent a potential mechanism underlying the reported hypolipidemic effect of phenols of extra virgin olive oil. (c) 2014 Elsevier Inc. All rights reserved. C1 [Priore, Paola; Siculella, Luisa; Gnoni, Gabriele Vincenzo] Univ Salento, Lab Biochem & Mol Biol, Dept Biol & Environm Sci & Technol, I-73100 Lecce, Italy. C3 University of Salento RP Siculella, L (通讯作者)，Univ Salento, Lab Biochem & Mol Biol, Dept Biol & Environm Sci & Technol, Via Provle Lecce Monteroni, I-73100 Lecce, Italy. EM luisa.siculella@unisalento.it OI Siculella, Luisa/0000-0002-6890-3674 FU Apulia Region (Italy); POR Strategic Projects [CIP PS_101] FX This work was supported by Grants from Apulia Region (Italy), POR Strategic Projects [Grant number: CIP PS_101]. 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PD JUL PY 2014 VL 25 IS 7 BP 683 EP 691 DI 10.1016/j.jnutbio.2014.01.009 PG 9 WC Biochemistry & Molecular Biology; Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Biochemistry & Molecular Biology; Nutrition & Dietetics GA AJ3FH UT WOS:000337551400001 PM 24742469 DA 2026-02-02 ER PT J AU Montero, D Blazer, VS Socorro, J Izquierdo, MS Tort, L AF Montero, D Blazer, VS Socorro, J Izquierdo, MS Tort, L TI Dietary and culture influences on macrophage aggregate parameters in gilthead seabream (Sparus aurata) juveniles SO AQUACULTURE LA English DT Article; Proceedings Paper CT 8th International Symposium on Nutrition and Feeding of Fish CY JUN 01-04, 1998 CL LAS PALMAS, SPAIN DE macrophage aggregates; n-3 HUFA; vitamin E; stress; Sparus aurata ID UNSATURATED FATTY-ACIDS; VITAMIN-E REQUIREMENT; OXIDIZED FISH-OIL; RAINBOW-TROUT; MELANOMACROPHAGE CENTERS; SALMO-GAIRDNERI; DISEASE; STRESS; ACCUMULATION; INFECTION AB Macrophage aggregates (MAs) are structures in the spleen, kidney and sometimes liver of fishes which have various functions such as recycling/storing/detoxification of cellular wastes and exogenous substances. They have been also reported to be important in the specific immune response and are used as health indicators. Changes in MA density, size and pigment content have been used in national and local monitoring programs in the U.S. as indicators of contaminant exposure. However, MA number and structure can also be affected by other factors, including general stress or nutritional status of fish. An experiment was conducted to study the effects of vitamin E and n -3 highly unsaturated fatty acid (HUFA) deficiencies and stocking density on spleen and kidney MAs of gilthead seabream, one of the most important species for Mediterranean aquaculture. Fish were held at two stocking densities, high and low, and fed experimental diets. Diet NE had no supplemental vitamin E, Diet NFA was deficient in n - 3 HUFA and Diet C was a control diet. Number, size and shape factor of MAs were measured using image analysis. The percentage of tissue occupied by MAs was calculated from these measurements. 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E., 1992, Annual Review of Fish Diseases, V2, P91, DOI 10.1016/0959-8030(92)90058-6 NR 47 TC 39 Z9 43 U1 1 U2 20 PU ELSEVIER SCIENCE BV PI AMSTERDAM PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS SN 0044-8486 J9 AQUACULTURE JI Aquaculture PD SEP 1 PY 1999 VL 179 IS 1-4 BP 523 EP 534 DI 10.1016/S0044-8486(99)00185-4 PG 12 WC Fisheries; Marine & Freshwater Biology WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S) SC Fisheries; Marine & Freshwater Biology GA 222DL UT WOS:000081768100044 DA 2026-02-02 ER PT J AU Baiges, I Palmfeldt, J Bladé, C Gregersen, N Arola, L AF Baiges, Isabel Palmfeldt, Johan Blade, Cinta Gregersen, Niels Arola, Lluis TI Lipogenesis Is Decreased by Grape Seed Proanthocyanidins According to Liver Proteomics of Rats Fed a High Fat Diet SO MOLECULAR & CELLULAR PROTEOMICS LA English DT Article ID ACID SYNTHASE INHIBITORS; LICORICE FLAVONOID OIL; INDUCED OBESE RATS; MEDITERRANEAN DIET; MESSENGER-RNA; MITOCHONDRIAL DYSFUNCTION; CARDIOVASCULAR-DISEASE; DENSITY-LIPOPROTEIN; METABOLIC SYNDROME; HEPATIC STEATOSIS AB Bioactive proanthocyanidins have been reported to have several beneficial effects on health in relation to metabolic syndrome, type 2 diabetes, and cardiovascular disease. We studied the effect of grape seed proanthocyanidin extract (GSPE) in rats fed a high fat diet (HFD). This is the first study of the effects of flavonoids on the liver proteome of rats suffering from metabolic syndrome. Three groups of rats were fed over a period of 13 weeks either a chow diet (control), an HFD, or a high fat diet supplemented for the last 10 days with GSPE (HFD + GSPE). The liver proteome was fractionated, using a Triton X-114-based two-phase separation, into soluble and membrane protein fractions so that total proteome coverage was considerably improved. The data from isobaric tag for relative and absolute quantitation (iTRAQ)-based nano-LC-MS/MS analysis revealed 90 proteins with a significant (p < 0.05) minimal expression difference of 20% due to metabolic syndrome (HFD versus control) and 75 proteins due to GSPE treatment (HFD + GSPE versus HFD). The same animals have previously been studied (Quesada, H., del Bas, J. M., Pajuelo, D., Diaz, S., Fernandez-Larrea, J., Pinent, M., Arola, L., Salvado, M. J., and Blade, C. (2009) Grape seed proanthocyanidins correct dyslipidemia associated with a high-fat diet in rats and repress genes controlling lipogenesis and VLDL assembling in liver. Int. J. Obes. 33, 1007-1012), and GSPE was shown to correct dyslipidemia observed in HFD-fed rats probably through the repression of hepatic lipogenesis. Our data corroborate those findings with an extensive list of proteins describing the induction of hepatic glycogenesis, glycolysis, and fatty acid and triglyceride synthesis in HFD, whereas the opposite pattern was observed to a large extent in GSPE-treated animals. GSPE was shown to have a wider effect than previously thought, and putative targets of GSPE involved in the reversal of the symptoms of metabolic syndrome were revealed. Some of these novel candidate proteins such as GFPT1, CD36, PLAA (phospholipase A(2)-activating protein), METTL7B, SLC30A1, several G signaling proteins, and the sulfide-metabolizing ETHE1 and SQRDL (sulfide-quinone reductase-like) might be considered as drug targets for the treatment of metabolic syndrome. Molecular & Cellular Proteomics 9:1499-1513, 2010. C1 [Baiges, Isabel; Blade, Cinta; Arola, Lluis] Univ Rovira & Virgili, Dept Biochem & Biotechnol, Nutrigenom Res Grp, Tarragona 43007, Spain. [Palmfeldt, Johan; Gregersen, Niels] Univ Aarhus, Res Unit Mol Med, Inst Clin Med, Aarhus Univ Hosp, DK-8200 Aarhus N, Denmark. [Palmfeldt, Johan; Gregersen, Niels] Univ Aarhus, Fac Hlth Sci, DK-8200 Aarhus N, Denmark. C3 Universitat Rovira i Virgili; Aarhus University; Aarhus University RP Baiges, I (通讯作者)，Univ Rovira & Virgili, Dept Biochem & Biotechnol, Nutrigenom Res Grp, C Marcel Li Domingo S-N, Tarragona 43007, Spain. EM isabel.baiges@urv.cat RI Arola, Lluís/C-6074-2011; Baiges, Isabel/B-7802-2008 OI Arola, Lluís/0000-0003-2767-1974; Palmfeldt, Johan/0000-0001-5585-639X; Bladé, Cinta/0000-0003-2838-2402 FU Spanish government [AGL2008-00387/ALI]; European Union FX This work was supported in part by Grant AGL2008-00387/ALI from Spanish government. The John and Birthe Meyer Foundation, and the Institute of Clinical Medicine at Aarhus University, Denmark.. S This article contains supplemental Tables S1 and S2. Supported partially by European Union COST (European Cooperation in Science and Technology) Action FA0602 COST Action Bioactive Food Components, Mitochondria and Health (MITOFOOD). To whom correspondence should be addressed: Dept. Bioquimica i Biotecnologia, Universitat Rovira i Virgili, C/Marcel-li Domingo s/n, 43007 Tarragona, Spain. Tel.: 34-977-55-84-86; Fax: 34-977-55-8232, E-mail: isabel.baiges@urv.cat. 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Proteomics PD JUL PY 2010 VL 9 IS 7 BP 1499 EP 1513 DI 10.1074/mcp.M000055-MCP201 PG 15 WC Biochemical Research Methods WE Science Citation Index Expanded (SCI-EXPANDED) SC Biochemistry & Molecular Biology GA 619AC UT WOS:000279397200011 PM 20332082 OA hybrid DA 2026-02-02 ER PT J AU Sofi, F Innocenti, G Dini, C Masi, L Battistini, NC Brandi, ML Rotella, CM Gensini, GF Abbate, R Surrenti, C Casini, A AF Sofi, Francesco Innocenti, Giulia Dini, Carla Masi, Laura Battistini, Nino Carlo Brandi, Maria Luisa Rotella, Carlo Maria Gensini, Gian Franco Abbate, Rosanna Surrenti, Calogero Casini, Alessandro TI Low adherence of a clinically healthy Italian population to nutritional recommendations for primary prevention of chronic diseases SO NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES LA English DT Article DE dietary habits; food consumption pattern; primary prevention; chronic disease; Mediterranean diet ID CORONARY-HEART-DISEASE; NONALCOHOLIC FATTY LIVER; MEDITERRANEAN DIET; MORTALITY; PATTERNS; RISK AB Background and aim: Several data demonstrated that dietary habits significantly affect the health state of the population. During recent years all the major scientific associations have provided nutritional recommendations for primary prevention of chronic diseases but few data are available about prevalence of adherence to these recommendations in an otherwise healthy population. The aims of this study were to evaluate dietary habits, and to assess the adherence of the general population to the recommendations for correct nutritional behaviour. Methods and results: Dietary habits, anthropometric and biochemical parameters were evaluated in a population of 932 (367 M; 565 F) clinically healthy subjects living in Florence, enrolled in an epidemiologic study conducted between 2002 and 2004. By comparing the dietary pattern with the nutritional guidelines, the study population reported a hyperproteic and hyperlipidic nutritional pattern, with a considerably tow contribution from polyunsaturated fats (PUFA). A tow fibre intake is shown in both genders. In addition, food consumption pattern showed an increased consumption of some foods such as meat, both fresh and processed, and a low intake of some "healthy" foods like fruit and vegetables. Conclusions: We found several nutritional flaws in the dietary habits of a clinically healthy Italian population. In particular, we reported a high intake of animal protein and total fats with a very low contribution from PUFA. (C) 2005 Elsevier B.V. All rights reserved. C1 Univ Florence, Azienda Osped Univ Careggi, Dept Med & Surg Crit Care, Thrombosis Ctr, Florence, Italy. Univ Florence, Azienda Osped Univ Careggi, Dept Clin Pathophysiol, Unit Nutr, Florence, Italy. Univ Florence, Azienda Osped Univ Careggi, Dept Clin Pathophysiol, Endocrinol Unit, Florence, Italy. Univ Florence, Azienda Osped Univ Careggi, Dept Internal Med, Florence, Italy. Univ Modena & Reggio Emilia, Fac Med, Dept Human Nutr, Modena, Italy. Univ Florence, Ctr Interdipartimentale Ric Valorizzaz Alimenti, I-50121 Florence, Italy. IRCCS, Fodaz Don Carlo Gnocchi Onlus, Ctr S Maria Agli Ulivi, Florence, Italy. C3 University of Florence; Azienda Ospedaliero Universitaria Careggi; University of Florence; Azienda Ospedaliero Universitaria Careggi; University of Florence; Azienda Ospedaliero Universitaria Careggi; University of Florence; Azienda Ospedaliero Universitaria Careggi; Universita di Modena e Reggio Emilia; University of Florence RP Sofi, F (通讯作者)，Univ Florence, Azienda Osped Univ Careggi, Dept Med & Surg Crit Care, Thrombosis Ctr, Florence, Italy. 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PD SEP PY 2006 VL 16 IS 6 BP 436 EP 444 DI 10.1016/j.numecd.2005.09.002 PG 9 WC Cardiac & Cardiovascular Systems; Endocrinology & Metabolism; Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Cardiovascular System & Cardiology; Endocrinology & Metabolism; Nutrition & Dietetics GA 102HO UT WOS:000241801800007 PM 16935702 OA Green Submitted DA 2026-02-02 ER PT J AU Ojeda-Granados, C Panduro, A Gonzalez-Aldaco, K Rivera-Iñiguez, I Campos-Medina, L Roman, S AF Ojeda-Granados, Claudia Panduro, Arturo Gonzalez-Aldaco, Karina Rivera-Iniguez, Ingrid Campos-Medina, Liliana Roman, Sonia TI Adherence to a Fish-Rich Dietary Pattern Is Associated with Chronic Hepatitis C Patients Showing Low Viral Load: Implications for Nutritional Management SO NUTRIENTS LA English DT Article DE hepatitis C virus; lipid metabolism; dietary pattern; nutritional profile; APOE; polyunsaturated fatty acid; fiber; spontaneous clearance; fibrosis ID DENSITY-LIPOPROTEIN CHOLESTEROL; VIRUS-RNA REPLICATION; MEDITERRANEAN DIET; ANTIVIRAL THERAPY; LIVER FIBROSIS; FATTY-ACIDS; LIPIDS; HCV; HEALTH; TRANSITION AB Hepatitis C virus (HCV) infection is influenced by genetic (e.g., APOE polymorphisms) and environmental factors between the virus and the host. HCV modulates the host's lipid metabolism but dietary components influence lipids and in vitro HCV RNA replication. Few data exist on the role of dietary features or patterns (DPs) in HCV infection. Herein, we aimed to evaluate the nutritional profiles of chronic HCV (CHC) and spontaneous clearance (SC) Mexican patients in the context of APOE alleles and their correlation with HCV-related variables. The fibrosis-related APOE epsilon 3 allele prevailed in CHC and SC patients, who had four DPs ( "meat and soft drinks ", DP1; "processed animal and fried foods ", DP2; "Mexican-healthy ", DP3; and "fish-rich ", DP4). In CHC subjects, polyunsaturated fatty acid intake (PUFA >= 4.9%) was negatively associated, and fiber intake (>= 21.5 g/day) was positively associated with a high viral load (p < 0.036). High adherence to fish-rich DP4 was associated with a higher frequency of CHC individuals consuming PUFA >= 4.9% (p = 0.004) and low viral load (p = 0.036), but a lower frequency of CHC individuals consuming fiber >= 21.5 g/day (p = 0.038). In SC and CHC individuals, modifying unhealthy DPs and targeting HCV-interacting nutrients, respectively, could be part of a nutritional management strategy to prevent further liver damage. C1 [Ojeda-Granados, Claudia; Panduro, Arturo; Gonzalez-Aldaco, Karina; Rivera-Iniguez, Ingrid; Campos-Medina, Liliana; Roman, Sonia] Civil Hosp Guadalajara Fray Antonio Alcalde, Dept Mol Biol Med, Hosp 278, Guadalajara 44280, Jalisco, Mexico. [Ojeda-Granados, Claudia; Panduro, Arturo; Gonzalez-Aldaco, Karina; Rivera-Iniguez, Ingrid; Campos-Medina, Liliana; Roman, Sonia] Univ Guadalajara, Hlth Sci Ctr, Guadalajara 44340, Jalisco, Mexico. C3 Universidad de Guadalajara RP Roman, S (通讯作者)，Civil Hosp Guadalajara Fray Antonio Alcalde, Dept Mol Biol Med, Hosp 278, Guadalajara 44280, Jalisco, Mexico.; Roman, S (通讯作者)，Univ Guadalajara, Hlth Sci Ctr, Guadalajara 44340, Jalisco, Mexico. EM claudiaojedagranados@hotmail.com; apanduro@prodigy.net.mx; karinaldaco@hotmail.com; ingrid_rivei@hotmail.com; lilianacamposm@gmail.com; soniamariaroman@hotmail.com RI Gonzalez-Aldaco, Karina/MVU-1601-2025; Rivera Iñiguez, Ingrid/GPK-5643-2022; Roman, Sonia/HSE-9426-2023; Campos, liliana/GXH-3763-2022 OI Gonzalez-Aldaco, Karina/0000-0001-5129-3307; Rivera Iñiguez, Ingrid/0000-0001-6129-6528; Roman Maldonado, Sonia Maria/0000-0001-7061-6634; FU Consejo Nacional de Ciencia y Tecnologia (CONACYT) [2017-01-5254] FX This research was partially funded by Consejo Nacional de Ciencia y Tecnologia (CONACYT) to A.P. (Grant No. 2017-01-5254). 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Hence, their health status, health management, and access to appropriate health care differ accordingly. In this Review, we examine data on the historical and prospective status of metabolic diseases in this region including obesity, diabetes, hypertension, dyslipidaemia, and non-alcoholic fatty liver disease. Women in the Middle East and north Africa have the highest risk of metabolic diseases of all women globally, whereas men rank second of all men in this respect. Metabolic risk factors are responsible for more than 300 deaths per 100 000 individuals in this region, compared with a global mean of fewer than 250. Physical inactivity, especially in women, and an unhealthy diet (ie, low consumption of whole grains, nuts, and seafoods) stand out. More than one in every three women are obese in most countries of the region. Prevention programmes have not fully been achieved in most of these countries and the projected future is not optimistic. Comprehensive surveillance and monitoring of metabolic diseases, robust multisectoral systems that support primordial and primary preventions, continuous education of health-care providers, as well as collaboration between countries for joint projects in this region are urgently needed to overcome the paucity of data and to improve the metabolic health status of inhabitants in the Middle East and north Africa. C1 [Azizi, Fereidoun; Amovzegar, Atieh; Abdi, Hengameh; Takyar, Farzin] Shahid Beheshti Univ Med Sci, Res Inst Endocrine Sci, Endocrine Res Ctr, Tehran, Iran. [Hadaegh, Farzad; Parizadeh, Donna; Lotfaliany, Mojtaba; Khali, Davood] Shahid Beheshti Univ Med Sci, Res Inst Endocrine Sci, Prevent Metab Disorders Res Ctr, Tehran, Iran. [Hosseinpanah, Farhad; Montazeri, Seyed Ali] Shahid Beheshti Univ Med Sci, Res Inst Endocrine Sci, Obes Res Ctr, Tehran, Iran. [Mirmiran, Parvin; Asghari, Golaleh] Shahid Beheshti Univ Med Sci, Res Inst Endocrine Sci, Nutr & Endocrine Res Ctr, Tehran, Iran. [Lotfaliany, Mojtaba; Khali, Davood] Shahid Beheshti Univ Med Sci, Res Inst Endocrine Sci, Dept Biostat & Epidemiol, Tehran, Iran. [Mirmiran, Parvin] Shahid Beheshti Univ Med Sci, Natl Nutr & Food Technol Res Inst, Fac Nutr Sci & Food Technol, Tehran, Iran. C3 Shahid Beheshti University Medical Sciences; Shahid Beheshti University Medical Sciences; Shahid Beheshti University Medical Sciences; Shahid Beheshti University Medical Sciences; Shahid Beheshti University Medical Sciences; Shahid Beheshti University Medical Sciences RP Khali, D (通讯作者)，Shahid Beheshti Univ Med Sci, Res Inst Endocrine Sci, Dept Biostat & Epidemiol, Tehran, Iran.; Khali, D (通讯作者)，Shahid Beheshti Univ Med Sci, Res Inst Endocrine Sci, Epidemiol, Tehran, Iran. EM dkhalili@endocrine.ac.ir RI Parizadeh, Donna/AAR-2539-2020; Asghari, Golaleh/N-4521-2013; Hadaegh, Farzad/K-2460-2017; hosseinpanah, farhad/AAM-7277-2020; Mirmiran, Parvin/V-1433-2019; Azizi, Fereidoun/ABD-4136-2021; abdi, hengameh/K-1592-2017; Lotfaliany, Mojtaba/ABB-6325-2020; hadaegh, farzad/K-2460-2017; Khalili, Davood/T-2913-2017 OI Parizadeh, Donna/0000-0001-8669-9454; Asghari, Golaleh/0000-0002-7925-5158; Lotfaliany Abrand Abadi, Mojtaba/0000-0001-6594-9004; Hadaegh, Farzad/0000-0002-8935-2744; Mirmiran, Parvin/0000-0003-2391-4924; Azizi, Fereidoun/0000-0002-6470-2517; abdi, hengameh/0000-0002-6850-0090; hadaegh, farzad/0000-0002-0352-8666; CR Al Sifri SN, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0084350 Al-Maqbali Ali Abdullah, 2013, Oman Med J, V28, P316, DOI 10.5001/omj.2013.94 Al-Nozha MM, 2007, SAUDI MED J, V28, P77 Al-Rubeaan K, 2015, J DIABETES, V7, P622, DOI 10.1111/1753-0407.12224 Al-Thani M, 2017, CUREUS J MED SCIENCE, V9, DOI 10.7759/cureus.1249 Alavian SM, 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PD NOV PY 2019 VL 7 IS 11 BP 866 EP 879 DI 10.1016/S2213-8587(19)30179-2 PG 14 WC Endocrinology & Metabolism WE Science Citation Index Expanded (SCI-EXPANDED) SC Endocrinology & Metabolism GA JD6WW UT WOS:000490124100018 PM 31422063 DA 2026-02-02 ER PT J AU Cao, K Xu, J Zou, X Li, Y Chen, C Zheng, AD Li, H Li, H Szeto, IMY Shi, YJ Long, JG Liu, JK Feng, ZH AF Cao, Ke Xu, Jie Zou, Xuan Li, Yuan Chen, Cong Zheng, Adi Li, Hao Li, Hua Szeto, Ignatius Man-Yau Shi, Yujie Long, Jiangang Liu, Jiankang Feng, Zhihui TI Hydroxytyrosol prevents diet-induced metabolic syndrome and attenuates mitochondrial abnormalities in obese mice SO FREE RADICAL BIOLOGY AND MEDICINE LA English DT Article DE Oxidative stress; Mitochondrial abnormalities; Insulin resistance; Hydroxytyrosol; Apoptosis; Free radicals ID INCREASED OXIDATIVE STRESS; PIGMENT EPITHELIAL-CELLS; FATTY LIVER-DISEASE; OLIVE LEAF EXTRACT; ANTIOXIDANT CAPACITY; INSULIN-RESISTANCE; HEPATIC STEATOSIS; SKELETAL-MUSCLE; OIL; DYSFUNCTION AB A Mediterranean diet rich in olive oil has profound influence on health outcomes including metabolic syndrome. However, the active compound and detailed mechanisms still remain unclear. Hydroxytyrosol (HT), a major polyphenolic compound in virgin olive oil, has received increased attention for its anti-oxidative activity and regulation of mitochondrial function. Here, we investigated whether HT is the active compound in olive oil exerting a protective effect against metabolic syndrome. In this study, we show that HT could prevent high-fat-diet (HFD)-induced obesity, hyperglycemia, hyperlipidemia, and insulin resistance in C57BL/6 J mice after 17 weeks supplementation. Within liver and skeletal muscle tissues, HT could decrease HFD-induced lipid deposits through inhibition of the SREBP-1c/FAS pathway, ameliorate HFD-induced oxidative stress by enhancing antioxidant enzyme activities, normalize expression of mitochondrial complex subunits and mitochondrial fission marker Drp1, and eventually inhibit apoptosis activation. Moreover, in muscle tissue, the levels of mitochondrial carbonyl protein were decreased and mitochondrial complex activities were significantly improved by HT supplementation. In db/db mice, HT significantly decreased fasting glucose, similar to metformin. Notably, HT decreased serum lipid, at which metformin failed. Also, HT was more effective at decreasing the oxidation levels of lipids and proteins in both liver and muscle tissue. Similar to the results in the HFD model, HT decreased muscle mitochondrial carbonyl protein levels and improved mitochondrial complex activities in db/db mice. Our study links the olive oil component HT to diabetes and metabolic disease through changes that are not limited to decreases in oxidative stress, suggesting a potential pharmaceutical or clinical use of HT in metabolic syndrome treatment. (C) 2013 Elsevier Inc. All rights reserved. C1 [Cao, Ke; Xu, Jie; Li, Yuan; Chen, Cong; Zheng, Adi; Li, Hao; Li, Hua; Szeto, Ignatius Man-Yau; Shi, Yujie; Long, Jiangang; Liu, Jiankang; Feng, Zhihui] Xi An Jiao Tong Univ, Ctr Mitochondrial Biol & Med, Xian 710049, Peoples R China. [Cao, Ke; Xu, Jie; Li, Yuan; Chen, Cong; Zheng, Adi; Li, Hao; Li, Hua; Szeto, Ignatius Man-Yau; Shi, Yujie; Long, Jiangang; Liu, Jiankang; Feng, Zhihui] Xi An Jiao Tong Univ, Key Lab Biomed Informat Engn, Minist Educ, Sch Life Sci & Technol, Xian 710049, Peoples R China. [Cao, Ke; Xu, Jie; Zou, Xuan; Li, Yuan; Chen, Cong; Zheng, Adi; Li, Hao; Li, Hua; Szeto, Ignatius Man-Yau; Shi, Yujie; Long, Jiangang; Liu, Jiankang; Feng, Zhihui] Xi An Jiao Tong Univ, Frontier Inst Sci & Technol, Xian 710049, Peoples R China. [Zou, Xuan] Xi An Jiao Tong Univ, Ctr Translat Med, Key Lab Biomed Informat Engn, Minist Educ,Sch Life Sci & Technol, Xian 710049, Peoples R China. C3 Xi'an Jiaotong University; Xi'an Jiaotong University; Xi'an Jiaotong University; Xi'an Jiaotong University RP Liu, JK (通讯作者)，Xi An Jiao Tong Univ, Ctr Mitochondrial Biol & Med, Xian 710049, Peoples R China. EM j.liu@mail.xjtu.edu.cn; zhfeng@mail.xjtu.edu.cn RI Li, Hao/K-7001-2017; Feng, Zhihui/E-7408-2011; Jiangang, Long/A-7835-2015; Xu, Jie/MNP-4744-2025; Zou, Xuan/A-6452-2015; Liu, Jiankang/A-1610-2011 OI Li, Hao/0000-0001-5677-3377; Feng, Zhihui/0000-0002-2448-6565; Jiangang, Long/0000-0001-8074-957X; FU National Natural Science Foundation of China [81201023, 31370844]; 973 Program [2014CB548200]; 985 Project of Xi'an Jiaotong University; 211 Project of Xi'an Jiaotong University FX This work was supported by the National Natural Science Foundation of China (Nos. 81201023, 31370844), the 973 Program (No. 2014CB548200), and the 985 and 211 Projects of Xi'an Jiaotong University. 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Pathak, Surajit TI Endothelial dysfunction, platelet hyperactivity, hypertension, and the metabolic syndrome: molecular insights and combating strategies SO FRONTIERS IN NUTRITION LA English DT Review DE metabolic syndrome; atherosclerotic cardiovascular disease; hypertension; endothelial dysfunction; platelet hyperactivity ID FATTY LIVER-DISEASE; ALL-CAUSE MORTALITY; CARDIOVASCULAR RISK; INSULIN-RESISTANCE; OXIDATIVE STRESS; MEDITERRANEAN DIET; CARDIOMETABOLIC RISK; BLOOD-PRESSURE; OBESITY; PREVALENCE AB Metabolic syndrome (MetS) is a multifaceted condition that increases the possibility of developing atherosclerotic cardiovascular disease. MetS includes obesity, hypertension, dyslipidemia, hyperglycemia, endothelial dysfunction, and platelet hyperactivity. There is a concerning rise in the occurrence and frequency of MetS globally. The rising incidence and severity of MetS need a proactive, multipronged strategy for identifying and treating those affected. For many MetS patients, achieving recommended goals for healthy fat intake, blood pressure control, and blood glucose management may require a combination of medicine therapy, lifestyles, nutraceuticals, and others. However, it is essential to note that lifestyle modification should be the first-line therapy for MetS. In addition, MetS requires pharmacological, nutraceutical, or other interventions. This review aimed to bring together the etiology, molecular mechanisms, and dietary strategies to combat hypertension, endothelial dysfunction, and platelet dysfunction in individuals with MetS. C1 [Das, Diptimayee; Shruthi, Nagainallur Ravichandran; Banerjee, Antara; Jothimani, Ganesan; Pathak, Surajit] Chettinad Acad Res & Educ, Chettinad Hosp & Res Inst, Fac Allied Hlth Sci, Kelambakkam, Tamil Nadu, India. [Duttaroy, Asim K. K.] Univ Oslo, Inst Med Sci, Fac Med, Dept Nutr, Oslo, Norway. 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Nutr. PD AUG 8 PY 2023 VL 10 AR 1221438 DI 10.3389/fnut.2023.1221438 PG 25 WC Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Nutrition & Dietetics GA P6TC9 UT WOS:001051970900001 PM 37614749 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Kajikawa, M Higashi, Y AF Kajikawa, Masato Higashi, Yukihito TI Obesity and Endothelial Function SO BIOMEDICINES LA English DT Review DE obesity; endothelial function; atherosclerosis; cardiovascular events ID BODY-MASS INDEX; EPICARDIAL ADIPOSE-TISSUE; FLOW-MEDIATED VASODILATION; FATTY LIVER-DISEASE; MEDITERRANEAN DIET; BARIATRIC SURGERY; NITRIC-OXIDE; INSULIN-RESISTANCE; METABOLIC SYNDROME; RISK-FACTORS AB Obesity is a major public health problem and is related to increasing rates of cardiovascular morbidity and mortality. Over 1.9 billion adults are overweight or obese worldwide and the prevalence of obesity is increasing. Obesity influences endothelial function through obesity-related complications such as hypertension, dyslipidemia, diabetes, metabolic syndrome, and obstructive sleep apnea syndrome. The excess fat accumulation in obesity causes adipocyte dysfunction and induces oxidative stress, insulin resistance, and inflammation leading to endothelial dysfunction. Several anthropometric indices and imaging modalities that are used to evaluate obesity have demonstrated an association between obesity and endothelial function. In the past few decades, there has been great focus on the mechanisms underlying endothelial dysfunction caused by obesity for the prevention and treatment of cardiovascular events. This review focuses on pathophysiological mechanisms of obesity-induced endothelial dysfunction and therapeutic targets of obesity. C1 [Kajikawa, Masato; Higashi, Yukihito] Hiroshima Univ Hosp, Med Ctr Translat & Clin Res, Div Regenerat & Med, Minami Ku, 1-2-3 Kasumi, Hiroshima 7348551, Japan. [Higashi, Yukihito] Hiroshima Univ, Res Inst Radiat Biol & Med, Div Radiat Med Sci, Dept Regenerat Med,Minami Ku, 1-2-3 Kasumi, Hiroshima 7348551, Japan. C3 Hiroshima University; Hiroshima University RP Higashi, Y (通讯作者)，Hiroshima Univ Hosp, Med Ctr Translat & Clin Res, Div Regenerat & Med, Minami Ku, 1-2-3 Kasumi, Hiroshima 7348551, Japan.; Higashi, Y (通讯作者)，Hiroshima Univ, Res Inst Radiat Biol & Med, Div Radiat Med Sci, Dept Regenerat Med,Minami Ku, 1-2-3 Kasumi, Hiroshima 7348551, Japan. EM m-kajikawa@hiroshima-u.ac.jp; yhigashi@hiroshima-u.ac.jp RI ; Higashi, Yukihito/G-5343-2019 OI Higashi, Yukihito/0000-0001-5813-3672; FU JSPS KAKENHI [18590815, 21590898, JP19K17599]; Takeda Science Foundation; Japanese Arteriosclerosis Prevention Fund; Grants-in-Aid for Scientific Research [23K24329, 22H03068] Funding Source: KAKEN FX This work was supported by JSPS KAKENHI (Grant Number 18590815 and 21590898 to Y.H. and JP19K17599 to M.K.), the Takeda Science Foundation (to M.K.), and a Grant in Aid of Japanese Arteriosclerosis Prevention Fund (to Y.H.). 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Pharmacology & Pharmacy WE Science Citation Index Expanded (SCI-EXPANDED) SC Biochemistry & Molecular Biology; Research & Experimental Medicine; Pharmacology & Pharmacy GA 3G6UM UT WOS:000831487100001 PM 35885049 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Barrea, L Macchia, PE Tarantino, G Di Somma, C Pane, E Balato, N Napolitano, M Colao, A Savastano, S AF Barrea, Luigi Macchia, Paolo Emidio Tarantino, Giovanni Di Somma, Carolina Pane, Elena Balato, Nicola Napolitano, Maddalena Colao, Annamaria Savastano, Silvia TI Nutrition: a key environmental dietary factor in clinical severity and cardio-metabolic risk in psoriatic male patients evaluated by 7-day food-frequency questionnaire SO JOURNAL OF TRANSLATIONAL MEDICINE LA English DT Article DE Environmental dietary factor; 7-day food records; PASI; HoMA-IR; VAI; FLI; MUFA ID VISCERAL ADIPOSITY INDEX; FATTY LIVER-DISEASE; HEPATIC STEATOSIS; CARDIOMETABOLIC RISK; MEDITERRANEAN DIET; INSULIN-RESISTANCE; ALPHA BLOCKERS; ARTHRITIS; INFLAMMATION; POPULATION AB Background: Western dietary pattern is included among the environmental dietary factors involved in the pathogenesis of psoriasis. Nutritional data collection methods and gender differences might affect the association between diet and psoriasis. The 7-day food records is considered the "gold standard" of self-administered food frequency questionnaires. In this study, we evaluated the differences in the dietary intake, anthropometric measurements and cardiometabolic risk profile in a group of psoriatic patients compared with an age and Body Mass Index (BMI)-matched control group. In addition, in the group of psoriatic patients we investigated the association between the dietary intake and clinical severity of psoriasis. Methods: Cross-sectional case control observational study. A total of 82 adult males, 41 treatment-naive patients with psoriasis and 41 healthy subjects matched for age and BMI were included in the study. The clinical severity of psoriasis was by assessed by Psoriasis Area and Severity Index (PASI) score. The dietary interview data were collected by a 7-day food records. Anthropometric measures, glucose and lipid profile, liver function tests and C-reactive protein levels were measured. Homeostasis Model Assessment of Insulin Resistance (HoMA-IR), Visceral Adiposity Index (VAI) and the Fatty Liver Index (FLI) were calculated. Results: Psoriatic patients consumed a higher percentage of total and simple carbohydrates, total fat, polyunsaturated fatty acid (PUFA) and n-6/n-3 PUFAs ratio, and cholesterol, while the consumption of protein, complex carbohydrates, monounsaturated fatty acid (MUFA), n-3 PUFA and fiber was lower than in the control group. In addition, psoriatic patients presented altered anthropometric measurements, glucose and lipid profile, liver function tests, and elevated values of HoMA-IR, VAI and FLI. PASI score well correlated with anthropometric measures, glucose and lipid profile, liver function tests, cardio-metabolic indices, and the dietary components, except for protein and total carbohydrates. At logistic regression analysis between PASI score and MUFA, MetS presence was well predicted only by higher PASI score (OR = 1.794; p = 0.002; CI 1.242-2.591). At multiple regression analysis, MUFA was the best predictor of PASI score (r(2) = 0.387, beta = -0.635, t = -5.127, p < 0.001). Conclusion: Differences in dietary intake were observed in adult male psoriatic patients compared with the controls. These differences were associated to the severity of the psoriasis and cardio-metabolic risk. FLI represented an early indicator of the cardio-metabolic risk profile in psoriatic patients, and dietary MUFA were major predictor of the clinical severity of psoriasis, while the association between psoriasis and metabolic syndrome appeared to be independent of MUFA intake. The low MUFA consumption might act as a possible adjunctive mechanism in increasing the inflammation milieu of psoriatic patients. C1 [Barrea, Luigi] IOS & COLEMAN Srl, Naples, Italy. [Macchia, Paolo Emidio; Tarantino, Giovanni; Pane, Elena; Balato, Nicola; Napolitano, Maddalena; Colao, Annamaria; Savastano, Silvia] Univ Naples Federico II, Dipartimento Med Clin & Chirurg, Med Sch Naples, I-80131 Naples, Italy. [Tarantino, Giovanni] IRCCS, Ist Nazl Studio & Cura Tumori Fdn Giovanni Pascal, Ctr Ric Oncol Mercogliano, Mercogliano, Italy. [Di Somma, Carolina] IRCCS SDN, I-80143 Naples, Italy. C3 University of Naples Federico II; IRCCS Istituto di Ricerca Diagnostica e Nucleare (SDN) RP Barrea, L (通讯作者)，IOS & COLEMAN Srl, Naples, Italy. EM luigi.barrea@unina.it RI Macchia, Paolo Emidio/B-7391-2012; Tarantino, Giovanni/AAW-2007-2021; Colao, Annamaria/A-7671-2011; Barrea, Luigi/K-6551-2016; Savastano, Silvia/K-6546-2016; Di Somma, Carolina/K-7772-2016 OI Macchia, Paolo Emidio/0000-0001-6503-6942; Napolitano, Maddalena/0000-0003-3309-8190; Barrea, Luigi/0000-0001-9054-456X; Savastano, Silvia/0000-0002-3211-4307; Di Somma, Carolina/0000-0002-5724-1951; Balato, Nicola/0000-0003-4871-2413 CR Abedini R, 2015, CLIN EXP DERMATOL, V40, P722, DOI 10.1111/ced.12672 Amato MC, 2011, LIPIDS HEALTH DIS, V10, DOI 10.1186/1476-511X-10-183 Amato MC, 2010, DIABETES CARE, V33, P920, DOI 10.2337/dc09-1825 Amato MC, 2014, INT J ENDOCRINOL, V2014, DOI 10.1155/2014/730827 [Anonymous], JAMA, V285, P2486 Ares G, 2007, APPETITE, V49, P148, DOI 10.1016/j.appet.2007.01.006 Barrea L, 2015, J TRANSL MED, V13, DOI 10.1186/s12967-014-0372-1 Bedogni G, 2006, BMC GASTROENTEROL, V6, DOI 10.1186/1471-230X-6-33 Berbert AA, 2005, NUTRITION, V21, P131, DOI 10.1016/j.nut.2004.03.023 Cicerale S, 2009, CHEM SENSES, V34, P333, DOI 10.1093/chemse/bjp006 Coto-Segura P, 2013, BRIT J DERMATOL, V169, P783, DOI 10.1111/bjd.12473 DeLany JP, 2000, AM J CLIN NUTR, V72, P905 Di Minno MND, 2012, J RHEUMATOL, V39, P1042, DOI 10.3899/jrheum.111391 Di Renzo L, 2012, PHARMACOGENET GENOM, V22, P134, DOI 10.1097/FPC.0b013e32834e5e7b Festugato M, 2011, AN BRAS DERMATOL, V86, P1103, DOI 10.1590/S0365-05962011000600006 Galland L, 2010, NUTR CLIN PRACT, V25, P634, DOI 10.1177/0884533610385703 Gillingham LG, 2011, LIPIDS, V46, P209, DOI 10.1007/s11745-010-3524-y Gisondi P, 2009, J HEPATOL, V51, P758, DOI 10.1016/j.jhep.2009.04.020 Glossmann H, 2013, DERM-ENDOCRINOL, V5, P252, DOI 10.4161/derm.23874 Guida B, 2014, CLIN NUTR, V33, P399, DOI 10.1016/j.clnu.2013.09.010 Haroon M, 2014, J RHEUMATOL, V41, P1357, DOI 10.3899/jrheum.140021 Hoidrup S, 2002, EUR J CLIN NUTR, V56, P105, DOI 10.1038/sj.ejcn.1601292 Hu FB, 2002, CURR OPIN LIPIDOL, V13, P3, DOI 10.1097/00041433-200202000-00002 Johnson JA, 2014, J EUR ACAD DERMATOL, V28, P327, DOI 10.1111/jdv.12105 Kim CR, 2013, ANN DERMATOL, V25, P440, DOI 10.5021/ad.2013.25.4.440 Lakdawala N, 2013, CLIN DERMATOL, V31, P677, DOI [10.1016/j.clindermatol.2013.05.004, 10.1016/j.clindermato1.2013.05.004] MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883 Millsop JW, 2014, J AM ACAD DERMATOL, V71, P561, DOI 10.1016/j.jaad.2014.03.016 Morken T, 2011, SCAND J CLIN LAB INV, V71, P269, DOI 10.3109/00365513.2011.559552 Onumah N, 2012, J DRUGS DERMATOL, V11, pS5 Rajaram S, 2010, BRIT J NUTR, V103, P907, DOI 10.1017/S0007114509992480 Ryan MC, 2013, J HEPATOL, V59, P138, DOI 10.1016/j.jhep.2013.02.012 Saraceno R, 2008, EUR REV MED PHARMACO, V12, P339 Spuls PI, 2010, J INVEST DERMATOL, V130, P933, DOI 10.1038/jid.2009.391 Tarantino G, 2010, WORLD J GASTROENTERO, V16, P4773, DOI 10.3748/wjg.v16.i38.4773 Thompson F.E., 2013, Nutrition in the prevention and treatment of disease, V3rd, P3, DOI 10.1016/B978-0-12-391884-0.00001-9 Thorburn AN, 2014, IMMUNITY, V40, P833, DOI 10.1016/j.immuni.2014.05.014 van der Voort EAM, 2014, J AM ACAD DERMATOL, V70, P517, DOI 10.1016/j.jaad.2013.10.044 Voiculescu V M, 2014, J Med Life, V7, P468 Westenhoefer J, 2005, FORUM NUTR, V57, P44, DOI 10.1159/000083753 Wolters M, 2006, HAUTARZT, V57, P999, DOI 10.1007/s00105-006-1164-1 NR 41 TC 71 Z9 77 U1 0 U2 18 PU BIOMED CENTRAL LTD PI LONDON PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND SN 1479-5876 J9 J TRANSL MED JI J. Transl. Med. PD SEP 16 PY 2015 VL 13 AR 303 DI 10.1186/s12967-015-0658-y PG 10 WC Medicine, Research & Experimental WE Science Citation Index Expanded (SCI-EXPANDED) SC Research & Experimental Medicine GA CR5BQ UT WOS:000361354700001 PM 26376719 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Quirós-Pozo, R Ventura-Castellano, A Ramírez-Bolaños, S Roo-Filgueira, J Robaina, L AF Quiros-Pozo, Raquel Ventura-Castellano, Anais Ramirez-Bolanos, Sara Roo-Filgueira, Javier Robaina, Lidia TI Evaluation of Aloe vera by-product against cereals in feeds for golden mullet (Liza aurata) SO AQUACULTURE REPORTS LA English DT Article DE Mugilidae; Liza aurata; Aloe vera; Aquaculture; Sustainable; By-product ID FED SUPPLEMENTED DIET; FISH-MEAL; STREPTOCOCCUS-INIAE; GROWTH-PERFORMANCE; LIPID-PEROXIDATION; ENZYME-ACTIVITIES; NATURAL EXTRACTS; MUGIL-CEPHALUS; ANTIOXIDANT; RESISTANCE AB Among of the actual challenges for the sustainable aquaculture development are to lower the trophic level of the cultured species, and to increase the use of by-products from the primary sector. The golden mullet (Liza aurata) is a marine low trophic level consumer present in the Mediterranean and in the Canary Islands, where there was a significant consumption in the past. On the other hand, Aloe vera plant, which production in Canary Islands is highly world representative, contains more than 70 biologically active components which have aroused the interest for its use in aquaculture, although the enormous quantity of the generated by-products has no use at all, and has never been tested for aquaculture purposes. The objective of this study was to run the first controlled feeding test with Liza aurata in the Canary Islands, as a target species to promote its cultivation, and to evaluate the use of pure Canarian Aloe vera against different levels of the by-product, to determine the effects in growth, health, and quality parameters. Therefore, 5 diets were formulated to contain 0% of aloe inclusion (diet control), 2% of pure form of aloe (diet P2), and 2, 4 and 6% of aloe by-product (diets BP2, BP4 and BP6). At 91 days of feeding, growth, proximal and fatty acid composition of liver, muscle and whole body, serum lysozyme, serum antibacterial activity, and malonaldheyde content of liver and whole body, were measured. According to obtained results, up to 6% of the aloe by-product could be included in diets for this species, without any rejections in growth or quality parameters, although no improved results compared to the control fish could be observed. Further studies are on the way to determine the sustainability and bioeconomic impact of present results, to gain knowledge on their direct industrial applications. C1 [Quiros-Pozo, Raquel; Ventura-Castellano, Anais; Ramirez-Bolanos, Sara; Roo-Filgueira, Javier; Robaina, Lidia] Univ Las Palmas Gran Canaria, IU ECOAQUA, Grp Invest Acuicultura, Las Palmas Gran Canaria, Spain. C3 Universidad de Las Palmas de Gran Canaria RP Quirós-Pozo, R (通讯作者)，ECOAQUA UI, Grp Invest Acuicultura, Parque Cient Tecnol Marino,Muelle Taliarte S-N, Las Palmas Gran Canaria 35200, Canary Islands, Spain. EM raquel.quiros101@alu.ulpgc.es RI ; Robaina, Lidia/I-2128-2015; Roo Filgueira, Javier/HKN-9786-2023 OI Ramírez-Bolaños, Sara/0000-0002-0635-4606; Roo Filgueira, Javier/0000-0002-9660-230X; Quirós-Pozo, Raquel/0000-0003-4135-1838 FU Project Interreg mac - Operational Programme of Territorial Cooperation MAC 2014-2020 [MAC/1.1a/207, MAC2/1.1a/299]; ERDF funds; University of Las Palmas de Gran Canaria FX This work was partially supported by the Project Interreg mac MAC/1.1a/207 R + D+I Towards aquaponics development in the up islands and the circular economy (Islandap) and by the Project Interreg mac MAC2/1.1a/299 R + D+i Towards aquaponics development in the up islands and the circular economy. Interregional forward challenges (Islandap Advance) , financed by the Operational Programme of Territorial Cooperation MAC 2014-2020 with ERDF funds. Thanks also to the University of Las Palmas de Gran Canaria, which supports a predoctoral grant for the first author Raquel Quiros Pozo, and all technicians at the Aquaculture and Biotechnology Specialized Services (SABE) belonging to the Ecoaqua University Institute. 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Rep. PD JUL PY 2021 VL 20 AR 100659 DI 10.1016/j.aqrep.2021.100659 EA MAR 2021 PG 8 WC Fisheries WE Science Citation Index Expanded (SCI-EXPANDED) SC Fisheries GA TI1UE UT WOS:000672569500003 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Koopmans, SJ Dekker, R Ackermans, MT Sauerwein, HP Serlie, MJ van Beusekom, HMM van den Heuvel, M van der Giessen, WJ AF Koopmans, Sietse J. Dekker, Ruud Ackermans, Mariette T. Sauerwein, Hans P. Serlie, Mireille J. van Beusekom, Heleen M. M. van den Heuvel, Mieke van der Giessen, Wim J. TI Dietary saturated fat/cholesterol, but not unsaturated fat or starch, induces C-reactive protein associated early atherosclerosis and ectopic fat deposition in diabetic pigs SO CARDIOVASCULAR DIABETOLOGY LA English DT Article DE Diabetes; Insulin; Diet; Unsaturated fat; Saturated fat; Cholesterol; Inflammation; C-reactive protein; Atherosclerosis; Pigs ID VASCULAR INFLAMMATION; INSULIN-RESISTANCE; PALEOLITHIC DIET; CARBOHYDRATE; INTERLEUKIN-6; NUTRIGENOMICS; HYPERGLYCEMIA; PROLIFERATOR; DYSFUNCTION; MELLITUS AB Background: Diabetes is thought to accelerate cardiovascular disease depending on the type of diet. This study in diabetic subjects was performed to investigate the metabolic, inflammatory and cardiovascular effects of nutritional components typically present in a Western, Mediterranean or high glycaemic diet. Methods: Streptozotocin-diabetic pigs (similar to 45 kg) were fed for 10 weeks supplemental (40% of dietary energy) saturated fat/cholesterol (SFC), unsaturated fat (UF) or starch (S) in an eucaloric dietary intervention study. Results: Fasting plasma total, LDL and HDL cholesterol concentrations were 3-5 fold higher (p < 0.01) in SFC compared to UF and S pigs. Fasting plasma NEFA concentrations (mmol/L) were highest (p < 0.05) in SFC (1.09 +/- 0.17), intermediate in UF (0.80 +/- 0.14) and lowest in S pigs (0.58 +/- 0.14) whereas plasma glucose (similar to 13 mmol/L), triglyceride (similar to 0.5 mmol/L) and insulin (similar to 24 pmol/L) concentrations were comparable among SFC, UF and S pigs. The postprandial response area under the curves (AUC, 0-4 h) for glucose but not for insulin and triglyceride responses were intermediate in SFC (617 +/- 144) and lowest (p < 0.05) in UF (378 +/- 157) compared to S pigs (925 +/- 139). Fasting hepatic glucose production, hepatic and peripheral insulin sensitivity and blood pressure were not different among pigs. C-reactive protein (CRP) concentrations (mg/L) were highest (p < 0.05) in SFC (25 +/- 4), intermediate in S (21 +/- 3) and lowest in UF pigs (14 +/- 2). Liver weights, liver and muscle triglyceride concentrations, and the surface area of aorta fatty streaks were highest (p < 0.01) in SFC pigs. A positive correlation between postprandial plasma CRP and aorta fatty streaks was observed in SFC pigs (R-2 = 0.95). Retroperitoneal fat depot weight (g) was intermediate in SFC (260 +/- 72), lowest in S (135 +/- 51) and highest (p < 0.05) in UF (571 +/- 95) pigs. Conclusion: Dietary saturated fat/cholesterol induces inflammation, atherosclerosis and ectopic fat deposition whereas an equally high dietary unsaturated fat load does not induce these abnormalities and shows beneficial effects on postprandial glycaemia in diabetic pigs. C1 [Koopmans, Sietse J.; Dekker, Ruud] Univ Wageningen & Res Ctr, Lelystad, Netherlands. [Koopmans, Sietse J.] Wageningen Univ, Dept Anim Sci, Adaptat Physiol Grp, Wageningen, Netherlands. [Ackermans, Mariette T.] Univ Amsterdam, Acad Med Ctr, Dept Endocrinol, NL-1105 AZ Amsterdam, Netherlands. [van Beusekom, Heleen M. M.; van den Heuvel, Mieke; van der Giessen, Wim J.] Erasmus MC, Rotterdam, Netherlands. [van der Giessen, Wim J.] ICIN KNAW, Utrecht, Netherlands. C3 Wageningen University & Research; Wageningen University & Research; University of Amsterdam; Academic Medical Center Amsterdam; Erasmus University Rotterdam; Erasmus MC RP Koopmans, SJ (通讯作者)，Univ Wageningen & Res Ctr, Lelystad, Netherlands. EM sietsejan.koopmans@wur.nl RI van Beusekom, Heleen/ACH-9683-2022 FU Ministry of Agriculture, Nature and Food Quality of The Netherlands FX This study is dedicated to our beloved friend and colleague WJG, deceased. This study was supported by the Ministry of Agriculture, Nature and Food Quality of The Netherlands. We thank Z. Mroz for the excellent surgical assistance. 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Diabetol. PD JUL 14 PY 2011 VL 10 AR 64 DI 10.1186/1475-2840-10-64 PG 11 WC Cardiac & Cardiovascular Systems; Endocrinology & Metabolism WE Science Citation Index Expanded (SCI-EXPANDED) SC Cardiovascular System & Cardiology; Endocrinology & Metabolism GA 797NB UT WOS:000293133500002 PM 21756316 OA Green Submitted, Green Published, gold DA 2026-02-02 ER PT J AU Zupa, R Rodríguez, C Mylonas, CC Rosenfeld, H Fakriadis, I Papadaki, M Pérez, JA Pousis, C Basilone, G Corriero, A AF Zupa, Rosa Rodriguez, Covadonga Mylonas, Constantinos C. Rosenfeld, Hanna Fakriadis, Ioannis Papadaki, Maria Perez, Jose A. Pousis, Chrysovalentinos Basilone, Gualtiero Corriero, Aldo TI Comparative Study of Reproductive Development in Wild and Captive-Reared Greater Amberjack Seriola dumerili (Risso, 1810) SO PLOS ONE LA English DT Article ID ATLANTIC BLUEFIN TUNA; POLYUNSATURATED FATTY-ACIDS; BASS DICENTRARCHUS-LABRAX; FINAL OOCYTE MATURATION; GERM-CELL PROLIFERATION; HORMONE AGONIST GNRHA; CARP CYPRINUS-CARPIO; SEA BASS; BROODSTOCK DIETS; EGG QUALITY AB The greater amberjack Seriola dumerili is a large teleost fish with rapid growth and excellent flesh quality, whose domestication represents an ambitious challenge for aquaculture. The occurrence of reproductive dysfunctions in greater amberjack reared in captivity was investigated by comparing reproductive development of wild and captive-reared individuals. Wild and captive-reared breeders were sampled in the Mediterranean Sea during three different phases of the reproductive cycle: early gametogenesis (EARLY, late April-early May), advanced gametogenesis (ADVANCED, late May-early June) and spawning (SPAWNING, late June-July). Fish reproductive state was evaluated using the gonado-somatic index (GSI), histological analysis of the gonads and determination of sex steroid levels in the plasma, and correlated with leptin expression in the liver and gonad biochemical composition. The GSI and sex steroid levels were lower in captive-reared than in wild fish. During the ADVANCED period, when the wild greater amberjack breeders were already in spawning condition, ovaries of captive-reared breeders showed extensive atresia of late vitellogenic oocytes and spermatogenic activity ceased in the testes of half of the examined males. During the SPAWNING period, all captive-reared fish had regressed gonads, while wild breeders still displayed reproductive activity. Liver leptin expression and gonad proximate composition of wild and captive greater amberjack were similar. However, the gonads of captive-reared fish showed different total polar lipid contents, as well as specific lipid classes and fatty acid profiles with respect to wild individuals. This study underlines the need for an improvement in rearing technology for this species, which should include minimum handling during the reproductive season and the formulation of a specific diet to overcome the observed gonadal decrements of phospholipids, DHA (22:6n-3) and ARA (20:4n-6), compared to wild breeders. C1 [Zupa, Rosa; Pousis, Chrysovalentinos; Corriero, Aldo] Univ Bari Aldo Moro, Dept Emergency & Organ Transplantat, Sect Vet Clin & Anim Prod, Valenzano, Bari, Italy. [Rodriguez, Covadonga; Perez, Jose A.] Univ La Laguna, Fac Ciencias, Dept Biol Anim Edafol & Geol, San Cristobal la Laguna, Tenerife, Spain. [Mylonas, Constantinos C.; Fakriadis, Ioannis; Papadaki, Maria] Hellen Ctr Marine Res, Inst Marine Biol Biotechnol & Aquaculture, Iraklion, Crete, Greece. [Rosenfeld, Hanna] Israel Oceanog & Limnol Res, Natl Ctr Mariculture, Elat, Israel. [Basilone, Gualtiero] CNR, Inst Marine Coastal Environm, Capo Granitola, TP, Italy. C3 Universita degli Studi di Bari Aldo Moro; Universidad de la Laguna; Hellenic Centre for Marine Research; Israel Oceanographic & Limnological Research Institute; Consiglio Nazionale delle Ricerche (CNR) RP Corriero, A (通讯作者)，Univ Bari Aldo Moro, Dept Emergency & Organ Transplantat, Sect Vet Clin & Anim Prod, Valenzano, Bari, Italy. EM aldo.corriero@uniba.it RI Rodríguez González, Covadonga/L-5173-2014; Pérez Pérez, José Antonio/L-4293-2014; Zupa, Rosa/ABE-9966-2021; Papadaki, Maria/AAP-4864-2020; Corriero, Aldo/AAH-1542-2021; Mylonas, Constantinos/G-9196-2011; Basilone, Gualtiero/D-2896-2017; Fakriadis, Ioannis/AAV-1558-2020 OI Rodríguez González, Covadonga/0000-0002-2805-0048; Pérez Pérez, José Antonio/0000-0002-5662-7246; Zupa, Rosa/0000-0001-5516-1299; Papadaki, Maria/0000-0002-7878-8868; Corriero, Aldo/0000-0001-7068-9438; Mylonas, Constantinos/0000-0003-1805-4392; Basilone, Gualtiero/0000-0002-5732-5055; Fakriadis, Ioannis/0000-0001-7180-3642; Pousis, Chrysovalentinos/0000-0003-4355-2393 FU European Union's Seventh Framework Programme for research, technological development and demonstration [KBBE-2013-07, 603121] FX Funding provided by the European Union's Seventh Framework Programme for research, technological development and demonstration, KBBE-2013-07 single stage: Exploring the biological and socio-economic potential of new/emerging candidate fish species for the expansion of the European aquaculture industry (DIVERSIFY) (Grant Agreement: 603121). 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If this was so, the condition should be able to be returned to normal by calorie restriction. The Counterpoint study tested this prediction in short-duration type 2 diabetes and showed that liver glucose handling returned to normal within 7 days and that beta-cell function returned close to normal over 8 weeks. Subsequent studies have demonstrated the durability of remission from type 2 diabetes. Remarkably, during the first 12 months of remission, the maximum functional beta-cell mass returns completely to normal and remains so for at least 24 months, consistent with regain of insulin secretory function of beta cells which had dedifferentiated in the face of chronic nutrient oversupply. The likelihood of achieving remission after 15% weight loss has been shown to be mainly determined by the duration of diabetes, with responders having better beta-cell function at baseline. Remission is independent of BMI, underscoring the personal fat threshold concept that type 2 diabetes develops when an individual acquires more fat than can be individually tolerated even at a BMI which in the nonobese range. Observations on people of South Asian or Afro-American ethnicity confirm that substantial weight loss achieves remission in the same way as in the largely White Europeans studied in detail. Diagnosis of type 2 diabetes can now be regarded as an urgent signal that weight loss must be achieved to avoid a progressive decline of health. C1 [Taylor, Roy] Newcastle Univ, Magnet Resonance Ctr, Inst Cellular Med, Newcastle Upon Tyne, Tyne & Wear, England. C3 Newcastle University - UK RP Taylor, R (通讯作者)，Newcastle Magnet Resonance Ctr, Med & Metab, Campus Ageing & Vital, Newcastle Upon Tyne NE4 5PL, Tyne & Wear, England. 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PD JUN PY 2021 VL 289 IS 6 BP 754 EP 770 DI 10.1111/joim.13214 EA DEC 2020 PG 17 WC Medicine, General & Internal WE Science Citation Index Expanded (SCI-EXPANDED) SC General & Internal Medicine GA SG8CZ UT WOS:000602190500001 PM 33289165 OA Green Submitted, Bronze DA 2026-02-02 ER PT J AU Korinek, M Handoussa, H Tsai, YH Chen, YY Chen, MH Chiou, ZW Fang, Y Chang, FR Yen, CH Hsieh, CF Chen, BH El-Shazly, M Hwang, TL AF Korinek, Michal Handoussa, Heba Tsai, Yi-Hong Chen, You-Ying Chen, Meng-Hua Chiou, Zan-Wei Fang, Yu Chang, Fang-Rong Yen, Chia-Hung Hsieh, Chung-Fan Chen, Bing-Hung El-Shazly, Mohamed Hwang, Tsong-Long TI Anti-Inflammatory and Antimicrobial Volatile Oils: Fennel and Cumin Inhibit Neutrophilic Inflammation via Regulating Calcium and MAPKs SO FRONTIERS IN PHARMACOLOGY LA English DT Article DE fennel; cumin; anti-inflammatory activity; respiratory burst; degranulation; formyl peptide receptor; antimicrobial activity; essential oil ID ACUTE LUNG INJURY; ELASTASE RELEASE; SUPEROXIDE ANION; ANTIOXIDANT ACTIVITIES; ANTIBACTERIAL ACTIVITY; FATTY-ACIDS; SUPPRESSION; CONSTITUENTS; ANTIBIOTICS; LEUKOCYTES AB Neutrophilic inflammatory diseases, such as chronic obstructive pulmonary disease (COPD), acute respiratory distress syndrome (ARDS), or psoriasis, exert a huge burden on the global health system due to the lack of safe and effective treatments. Volatile oils from terrestrial plants showed impressive therapeutic effects against disorders of the skin, digestive system, lungs, liver, metabolism, and nervous system. However, their effect on the immune system and neutrophil function is still elusive. Fennel, cumin, marjoram, lavender, caraway, and anise are the common nutraceuticals that are widely used in the Mediterranean diet. The volatile oils of these herbs were screened for various biological activities, including anti-inflammatory, anti-allergic, antimicrobial, and antiviral effects. Several oils showed anti-inflammatory and antimicrobial potential. Fennel (Foeniculum vulgare) and cumin (Cuminum cyminum) fruits' volatile oils significantly suppressed the activation of human neutrophils, including respiratory burst and the degranulation induced by formyl peptide receptor agonists fMLF/CB and MMK1 in the human neutrophils (IC50, 3.8-17.2 mu g/ml). The cytotoxic effect and free-radical scavenging effects (ABTS, DPPH) of these oils did not account for the observed effects. Both fennel and cumin volatile oils significantly shortened calcium influx recovery time and inhibited phosphorylation of mitogen-activated protein kinases (p38, JNK, and ERK) expression. The gas chromatography-mass spectrometry analysis of these oils revealed the presence of estragole and cuminaldehyde as the major components of fennel and cumin volatile oils, respectively. Our findings suggested that cumin and fennel, common in the Mediterranean diet, hold the potential to be applied for the treatment of neutrophilic inflammatory diseases. C1 [Korinek, Michal; Tsai, Yi-Hong; Chang, Fang-Rong; Yen, Chia-Hung] Kaohsiung Med Univ, Grad Inst Nat Prod, Coll Pharm, Kaohsiung, Taiwan. [Korinek, Michal; Chen, Meng-Hua; Chiou, Zan-Wei; Fang, Yu; Hwang, Tsong-Long] Chang Gung Univ, Grad Inst Nat Prod, Coll Med, Taoyuan, Taiwan. [Korinek, Michal; Chen, Bing-Hung] Kaohsiung Med Univ, Dept Biotechnol, Coll Life Sci, Kaohsiung, Taiwan. [Handoussa, Heba; El-Shazly, Mohamed] German Univ Cairo, Fac Pharm & Biotechnol, Dept Pharmaceut Biol, Cairo, Egypt. [Chen, You-Ying] Natl Sun Yat Sen Univ, Dept Marine Biotechnol & Resources, Kaohsiung, Taiwan. [Hsieh, Chung-Fan] Chang Gung Univ, Coll Med, Res Ctr Emerging Viral Infect, Taoyuan, Taiwan. [El-Shazly, Mohamed] Ain Shams Univ, Dept Pharmacognosy, Fac Pharm, Cairo, Egypt. [Hwang, Tsong-Long] Chang Gung Univ Sci & Technol, Grad Inst Hlth Ind Technol, Coll Human Ecol, Res Ctr Chinese Herbal Med, Taoyuan, Taiwan. [Hwang, Tsong-Long] Chang Gung Mem Hosp, Dept Anesthesiol, Taoyuan, Taiwan. [Hwang, Tsong-Long] Ming Chi Univ Technol, Dept Chem Engn, New Taipei, Taiwan. C3 Kaohsiung Medical University; Chang Gung University; Kaohsiung Medical University; Egyptian Knowledge Bank (EKB); German University in Cairo; National Sun Yat Sen University; Chang Gung University; Egyptian Knowledge Bank (EKB); Ain Shams University; Chang Gung University of Science & Technology; Chang Gung Memorial Hospital; Ming Chi University of Technology RP Hwang, TL (通讯作者)，Chang Gung Univ, Grad Inst Nat Prod, Coll Med, Taoyuan, Taiwan.; Handoussa, H; El-Shazly, M (通讯作者)，German Univ Cairo, Fac Pharm & Biotechnol, Dept Pharmaceut Biol, Cairo, Egypt.; El-Shazly, M (通讯作者)，Ain Shams Univ, Dept Pharmacognosy, Fac Pharm, Cairo, Egypt.; Hwang, TL (通讯作者)，Chang Gung Univ Sci & Technol, Grad Inst Hlth Ind Technol, Coll Human Ecol, Res Ctr Chinese Herbal Med, Taoyuan, Taiwan.; Hwang, TL (通讯作者)，Chang Gung Mem Hosp, Dept Anesthesiol, Taoyuan, Taiwan.; Hwang, TL (通讯作者)，Ming Chi Univ Technol, Dept Chem Engn, New Taipei, Taiwan. EM heba.handoussa@guc.edu.eg; mohamed.elshazly@pharma.asu.edu.eg; htl@mail.cgu.edu.tw RI Yen, Chia-Hung/AFL-8668-2022; Korinek, Michal/HPD-6457-2023; El-Shazly, Mohamed/ACA-4512-2022; Chen, You-Ying/PDW-9966-2025; Hwang, Tsong-Long/AAE-6944-2020; Chen, Bing-Hung/F-4451-2010; Chang, Fang-Rong/C-5692-2009 OI Yen, Chia-Hung/0000-0002-6939-5528; Tsai, Yi-Hong/0000-0003-4674-3363; Chen, You-Ying/0000-0002-8999-2290; FU Ministry of Science and Technology, Taiwan FX This research was supported by grants from the Ministry of Science and Technology, Taiwan (MOST 108-2320-B-255-003-MY3, MOST 109-2327-B-255-001, MOST 109-2327-B-182-002 awarded to TH, MOST 108-2320-B-037-022-MY3 awarded to FC, MOST 109-2320-B-037-004-MY3 awarded to BC, and MOST 109-2811-I-006-500 awarded to MK). This study was also supported by Chang Gung Memorial Hospital (CMRPF1G0241 similar to 3, CMRPF1J0051 similar to 3, and BMRP450), Chang Gung University of Science and Technology (ZRRPF3L0091) awarded to TH. In addition, this research was funded by the Drug Development and Value Creation Research Center, Kaohsiung Medical University and Department of Medical Research, Kaohsiung Medical University Hospital, Taiwan (KMU-TC108A03-11 and KMU-TC109A03-2) awarded to FC. The funders had no role in the study design, data collection, analyses, decision to publish, or preparation of the manuscript. 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Pharmacol. PD OCT 11 PY 2021 VL 12 AR 674095 DI 10.3389/fphar.2021.674095 PG 20 WC Pharmacology & Pharmacy WE Science Citation Index Expanded (SCI-EXPANDED) SC Pharmacology & Pharmacy GA WU6PZ UT WOS:000716666600001 PM 34707494 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Bourdineaud, JP Fujimura, M Laclau, M Sawada, M Yasutake, A AF Bourdineaud, Jean-Paul Fujimura, Masatake Laclau, Muriel Sawada, Masumi Yasutake, Akira TI Deleterious effects in mice of fish-associated methylmercury contained in a diet mimicking the Western populations' average fish consumption SO ENVIRONMENT INTERNATIONAL LA English DT Article DE Fish consumption; Methylmercury; Ecotoxicology; Tuna ID MERCURY EXPOSURE; FATTY-ACIDS; SEROTONINERGIC NEUROTRANSMISSION; PRENATAL EXPOSURE; DOPAMINE RELEASE; PERFORMANCE; CHILDREN; DISEASE; ADULT; RATS AB Methylmercury (MeHg) is a potent neurotoxin, and human beings are mainly exposed to this pollutant through fish consumption. Only a few contradictory epidemiological studies are currently available examining the impact of fish consumption on human populations. In the present study, we wanted to address whether a diet mimicking the fish consumption of Western populations could result in observable adverse effects in mice, and whether beneficial nutriments from fish were able to counterbalance the deleterious effects of MeHg, if any. In Europe and the United States, fish consumption varies widely between countries, from 11 to 100 g fish/day. A mid-range value of 25 g fish/day corresponds to a fish contribution to the total diet of 125% on a dry weight basis. We decided to supplement a vegetarian-based mouse diet with 1.25% of lyophilized salmon flesh (SAL diet), or 125% of a blend of lyophilized cod, tuna, and swordfish (CTS diet). Total mercury contents were 1.15 +/- 0.15, 2.3 +/- 0.1 and 35.75 +/- 0.15 ng Hg/g of food pellets for the control, SAL and CTS diets, respectively. After two months feeding, the CTS diet resulted in significant observable effects as compared to the control and SAL diets, encompassing decreased body growth, altered behavioral performance and increased anxiety level, modification of mitochondrial respiratory protein subunit concentrations in kidney and brain structures, modified gene expression patterns in kidneys, liver and muscles, and a decrease of dopamine concentrations in the hypothalamus and striatum. Our findings have health implications, firstly because 1.25% of CTS flesh in the diet corresponds to an average exposure to MeHg below the WHO provisory tolerable weekly intake (PTWI) (1.6 mu g MeHg/kg of body weight/week), and secondly because many people in Western populations, among them women of child-bearing age, are exceeding the PTWI value (for instance, 35% of the French population inhabiting the Atlantic and Mediterranean coasts). (c) 2010 Elsevier Ltd. All rights reserved. C1 [Bourdineaud, Jean-Paul; Laclau, Muriel] Bordeaux Univ, CNRS, UMR EPOC 5805, Arcachon Marine Stn, F-33120 Arcachon, France. [Fujimura, Masatake; Sawada, Masumi; Yasutake, Akira] Natl Inst Minamata Dis, Pathol Sect, Dept Basic Med Sci, Kumamoto 8670008, Japan. C3 Centre National de la Recherche Scientifique (CNRS) RP Bourdineaud, JP (通讯作者)，Bordeaux Univ, CNRS, UMR EPOC 5805, Arcachon Marine Stn, Pl Docteur Peyneau, F-33120 Arcachon, France. EM jp.bourdineaud@epoc.u-bordeaux1.fr FU Agence Nationale de la Recherche [05 SEST 034 01] FX We thank Lindsay Hislop for having corrected and checked the English language of this article and the Agence Nationale de la Recherche for its financial support (grant number 05 SEST 034 01). 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PD FEB PY 2011 VL 37 IS 2 BP 303 EP 313 DI 10.1016/j.envint.2010.09.003 PG 11 WC Environmental Sciences WE Science Citation Index Expanded (SCI-EXPANDED) SC Environmental Sciences & Ecology GA 725BL UT WOS:000287620100001 PM 21035857 DA 2026-02-02 ER PT J AU Luna-Castillo, KP Olivares-Ochoa, XC Hernández-Ruiz, RG Llamas-Covarrubias, IM Rodríguez-Reyes, SC Betancourt-Núñez, A Vizmanos, B Martínez-López, E Muñoz-Valle, JF Márquez-Sandoval, F López-Quintero, A AF Luna-Castillo, Karla Paulina Olivares-Ochoa, Xochitl Citlalli Hernandez-Ruiz, Rocio Guadalupe Llamas-Covarrubias, Iris Monserrat Rodriguez-Reyes, Sarai Citlalic Betancourt-Nunez, Alejandra Vizmanos, Barbara Martinez-Lopez, Erika Munoz-Valle, Jose Francisco Marquez-Sandoval, Fabiola Lopez-Quintero, Andres TI The Effect of Dietary Interventions on Hypertriglyceridemia: From Public Health to Molecular Nutrition Evidence SO NUTRIENTS LA English DT Article DE dietary interventions; triglycerides; hypertriglyceridemia; clinical trial; molecular nutrition ID CARDIOVASCULAR RISK-FACTORS; HIGH PROTEIN/LOW CARBOHYDRATE; DOUBLE-BLIND; INSULIN-RESISTANCE; LIPID PROFILE; LOW-FAT; METABOLIC SYNDROME; OBESE ADULTS; WEIGHT-LOSS; FAMILIAL HYPERCHOLESTEROLEMIA AB Approximately 25-50% of the population worldwide exhibits serum triglycerides (TG) (>= 150 mg/dL) which are associated with an increased level of highly atherogenic remnant-like particles, non-alcoholic fatty liver disease, and pancreatitis risk. High serum TG levels could be related to cardiovascular disease, which is the most prevalent cause of mortality in Western countries. The etiology of hypertriglyceridemia (HTG) is multifactorial and can be classified as primary and secondary causes. Among the primary causes are genetic disorders. On the other hand, secondary causes of HTG comprise lifestyle factors, medical conditions, and drugs. Among lifestyle changes, adequate diets and nutrition are the initial steps to treat and prevent serum lipid alterations. Dietary intervention for HTG is recommended in order to modify the amount of macronutrients. Macronutrient distribution changes such as fat or protein, low-carbohydrate diets, and caloric restriction seem to be effective strategies in reducing TG levels. Particularly, the Mediterranean diet is the dietary pattern with the most consistent evidence for efficacy in HTG while the use of omega-3 supplements consumption is the dietary component with the highest number of randomized clinical trials (RCT) carried out with effective results on reducing TG. The aim of this review was to provide a better comprehension between human nutrition and lipid metabolism. C1 [Luna-Castillo, Karla Paulina; Olivares-Ochoa, Xochitl Citlalli; Hernandez-Ruiz, Rocio Guadalupe; Llamas-Covarrubias, Iris Monserrat; Rodriguez-Reyes, Sarai Citlalic; Betancourt-Nunez, Alejandra; Vizmanos, Barbara; Martinez-Lopez, Erika; Munoz-Valle, Jose Francisco; Marquez-Sandoval, Fabiola; Lopez-Quintero, Andres] Univ Guadalajara UdeG, Ctr Univ Ciencias Salud CUCS, Doctorado Ciencias Nutr Traslac, Guadalajara 44340, Jalisco, Mexico. [Llamas-Covarrubias, Iris Monserrat; Rodriguez-Reyes, Sarai Citlalic; Vizmanos, Barbara; Martinez-Lopez, Erika; Marquez-Sandoval, Fabiola; Lopez-Quintero, Andres] UdeG, CUCS, Inst Nutrigenet & Nutrigen Traslac, Guadalajara 44340, Jalisco, Mexico. [Munoz-Valle, Jose Francisco] UdeG, CUCS, Inst Invest Ciencias Biomed, Guadalajara 44340, Jalisco, Mexico. RP Márquez-Sandoval, F; López-Quintero, A (通讯作者)，Univ Guadalajara UdeG, Ctr Univ Ciencias Salud CUCS, Doctorado Ciencias Nutr Traslac, Guadalajara 44340, Jalisco, Mexico.; Márquez-Sandoval, F; López-Quintero, A (通讯作者)，UdeG, CUCS, Inst Nutrigenet & Nutrigen Traslac, Guadalajara 44340, Jalisco, Mexico. EM karla.luna3337@alumnos.udg.mx; karla.luna3337@alumnos.udg.mx; karla.luna3337@alumnos.udg.mx; karla.luna3337@alumnos.udg.mx; karla.luna3337@alumnos.udg.mx; karla.luna3337@alumnos.udg.mx; karla.luna3337@alumnos.udg.mx; karla.luna3337@alumnos.udg.mx; karla.luna3337@alumnos.udg.mx; karla.luna3337@alumnos.udg.mx; karla.luna3337@alumnos.udg.mx RI Vizmanos, Barbara/D-7805-2017; MARTINEZ-LOPEZ, ERIKA/Y-6384-2019 OI Vizmanos, Barbara/0000-0003-0680-0802; Llamas, Iris/0000-0001-5922-7216; Hernández Ruiz, Rocio/0000-0001-7303-1164; Betancourt, Alejana/0000-0001-6592-3031; Fabiola, Márquez-Sandoval/0000-0002-4530-3940; LÓPEZ-QUINTERO, ANES/0000-0002-5151-041X; Olivares-Ochoa, Xochitl Citlalli/0000-0002-4456-4620; MARTINEZ-LOPEZ, ERIKA/0000-0003-2005-9512; Luna-Castillo, Karla Paulina/0000-0003-0132-8385; Muñoz-Valle, José Francisco/0000-0002-2272-9260 FU Universidad de Guadalajara, Centro Universitario de Ciencias de la Salud; [954388]; [CVU 1103832]; [CVU 1104138] FX This research was funded by Universidad de Guadalajara, Centro Universitario de Ciencias de la Salud. 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probiotics; prebiotics ID TRIMETHYLAMINE-N-OXIDE; FATTY LIVER-DISEASE; CARDIOVASCULAR RISK-FACTORS; PROTEIN-COUPLED RECEPTOR; HUMAN COLONIC MICROBIOTA; LOW-GRADE INFLAMMATION; INTESTINAL MICROBIOTA; MEDITERRANEAN DIET; INDOXYL SULFATE; WESTERN DIET AB Metabolic syndrome (MetS) is a complex pathophysiological state with incidence similar to that of a global epidemic and represents a risk factor for the onset of chronic non-communicable degenerative diseases (NCDDs), including cardiovascular disease (CVD), type 2 diabetes mellitus, chronic kidney disease, and some types of cancer. A plethora of literature data suggest the potential role of gut microbiota in interfering with the host metabolism, thus influencing several MetS risk factors. Perturbation of the gut microbiota's composition and activity, a condition known as dysbiosis, is involved in the etiopathogenesis of multiple chronic diseases. Recent studies have shown that some micro-organism-derived metabolites (including trimethylamine N-oxide (TMAO), lipopolysaccharide (LPS) of Gram-negative bacteria, indoxyl sulfate and p-cresol sulfate) induce subclinical inflammatory processes involved in MetS. Gut microbiota's taxonomic species or abundance are modified by many factors, including diet, lifestyle and medications. The main purpose of this review is to highlight the correlation between different dietary strategies and changes in gut microbiota metabolites. 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Zaharia, Oana-Patricia Barosa, Cristina Herder, Christian Wickrath, Frithjof Bobrov, Pavel Hwang, Jong-Hee Jones, John Griffith Roden, Michael TI Monounsaturated fat rapidly induces hepatic gluconeogenesis and whole-body insulin resistance SO JCI INSIGHT LA English DT Article ID GLUCOSE; LIVER; SENSITIVITY; METABOLISM; MUSCLE; OBESE; MECHANISMS; PLASMA; TISSUE; SERIES AB BACKGROUND. While saturated fat intake leads to insulin resistance and nonalcoholic fatty liver, Mediterranean-like diets enriched in monounsaturated fatty acids (MUFA) may have beneficial effects. This study examined effects of MUFA on tissue-specific insulin sensitivity and energy metabolism. METHODS. A randomized placebo-controlled cross-over study enrolled 16 glucose-tolerant volunteers to receive either oil (OIL, similar to 1.18 g/kg), rich in MUFA, or vehicle (VCL, water) on 2 occasions. Insulin sensitivity was assessed during preclamp and hyperinsulinemic-euglycemic clamp conditions. Ingestion of (H2O)-H-2/acetaminophen was combined with [6,6-H-2(2)]glucose infusion and in vivo C-13/P-31/H-1/ex vivo H-2-magnet resonance spectroscopy to quantify hepatic glucose and energy fluxes. RESULTS. OIL increased plasma triglycerides and oleic acid concentrations by 44% and 66% compared with VCL. Upon OIL intervention, preclamp hepatic and whole-body insulin sensitivity markedly decreased by 28% and 27%, respectively, along with 61% higher rates of hepatic gluconeogenesis and 32% lower rates of net glycogenolysis, while hepatic triglyceride and ATP concentrations did not differ from VCL. During insulin stimulation hepatic and whole-body insulin sensitivity were reduced by 21% and 25%, respectively, after OIL ingestion compared with that in controls. CONCLUSION. A single MUFA-load suffices to induce insulin resistance but affects neither hepatic triglycerides nor energy-rich phosphates. These data indicate that amount of ingested fat, rather than its composition, primarily determines the development of acute insulin resistance. C1 [Sarabhai, Theresia; Kahl, Sabine; Szendroedi, Julia; Markgraf, Daniel F.; Zaharia, Oana-Patricia; Herder, Christian; Wickrath, Frithjof; Hwang, Jong-Hee; Roden, Michael] Heinrich Heine Univ Dusseldorf, German Diabet Ctr, Inst Clin Diabetol, Leibniz Ctr Diabet Res, Dusseldorf, Germany. [Sarabhai, Theresia; Kahl, Sabine; Szendroedi, Julia; Markgraf, Daniel F.; Zaharia, Oana-Patricia; Herder, Christian; Wickrath, Frithjof; Bobrov, Pavel; Hwang, Jong-Hee; Roden, Michael] German Ctr Diabet Res, Munich, Germany. [Barosa, Cristina; Jones, John Griffith] UC Biotech, Ctr Neurosci & Cell Biol, Cantanhede, Portugal. [Barosa, Cristina; Jones, John Griffith] Portuguese Diabet Assoc, Lisbon, Portugal. [Bobrov, Pavel] Heinrich Heine Univ Dusseldorf, German Diabet Ctr, Inst Biometr & Epidemiol, Leibniz Ctr Diabet Res, Dusseldorf, Germany. [Roden, Michael] Heinrich Heine Univ Dusseldorf, Med Fac, Div Endocrinol & Diabetol, Dusseldorf, Germany. C3 Heinrich Heine University Dusseldorf; Leibniz Association; Deutsches Diabetes-Zentrum (DDZ); German Center for Diabetes Research (DZD); Universidade de Coimbra; Leibniz Association; Deutsches Diabetes-Zentrum (DDZ); Heinrich Heine University Dusseldorf; Heinrich Heine University Dusseldorf RP Roden, M (通讯作者)，Heinrich Heine Univ, Inst Clin Diabetol, German Diabet Ctr, Leibniz Ctr Diabet Res, Aufm Hennekamp 65, D-40225 Dusseldorf, Germany. EM michael.roden@ddz.de RI ; Barosa de Oliveira, Maria Cristina/A-6377-2014; Roden, Michael/AAD-3843-2019; Zaharia, Oana/AAV-1885-2021; Jones, John/A-8684-2010 OI Sarabhai, Theresia/0009-0008-2385-5200; Wickrath, Frithjof/0000-0002-1103-9133; Barosa de Oliveira, Maria Cristina/0000-0001-7819-2434; Jones, John/0000-0002-3745-3885 FU German Federal Ministry of Health; Ministry of Culture and Science of the State North Rhine-Westphalia; German Federal Ministry of Education and Research; European Regional Development Fund (KomIT) [EFRE-0400191]; German Research Foundation (DFG) [SFB 1116/2]; Portuguese Foundation for Science and Technology [FCT-FEDER-02/SAICT/2017/028147, POCI-01-0145-FEDER-007440, REEQ/481/QUI/2006, RECI/QEQ-QFI/0168/2012, CENTRO-07-CT62-FEDER-002012]; structural funding for the Centre for Neurosciences and Cell Biology; UC-NMR facility - European Regional Development Fund (FEDER) -through the COMPETE Programme; Rede Nacional de Ressonancia Magnetica Nuclear FX We would like to thank Paul Begovatz, Myrko Esser, David Hohn, Bettina Nowotny, Peter Nowotny, Ulrike Partke, Andrea Sparla, and Kai Tinnes for their excellent support. This study was supported by grants to the German Diabetes Center, which is funded by the German Federal Ministry of Health and the Ministry of Culture and Science of the State North Rhine-Westphalia, and to the German Center for Diabetes Research by the German Federal Ministry of Education and Research, the European Regional Development Fund (KomIT, EFRE-0400191), the German Research Foundation (DFG; SFB 1116/2), and the Portuguese Foundation for Science and Technology (FCT-FEDER-02/SAICT/2017/028147). This study was also supported by structural funding for the Centre for Neurosciences and Cell Biology and the UC-NMR facility, supported in part by European Regional Development Fund (FEDER) -through the COMPETE Programme and the Portuguese Foundation for Science and Technology (POCI-01-0145-FEDER-007440, REEQ/481/QUI/2006, RECI/QEQ-QFI/0168/2012, CENTRO-07-CT62-FEDER-002012), and Rede Nacional de Ressonancia Magnetica Nuclear. The funding sources had no role in the design, execution, analyses, and interpretation of the data of this study or decision to submit results. MR is the guarantor of this work and, as such, had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. 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Lichtenstein, Alice H. Chung, Mei Kupelnick, Bruce Chew, Priscilla Lau, Joseph TI Effects of omega-3 fatty acids on serum markers of cardiovascular disease risk: A systematic review SO ATHEROSCLEROSIS LA English DT Review DE omega-3 fatty acid; cardiovascular disease; fish oil; systematic review; meta-analysis ID N-3 FATTY-ACIDS; ALPHA-LINOLENIC ACID; C-REACTIVE PROTEIN; INDO-MEDITERRANEAN DIET; RANDOMIZED CONTROLLED-TRIAL; FISH-OIL SUPPLEMENTATION; HIGH-DENSITY-LIPOPROTEIN; COD-LIVER-OIL; BLOOD-PRESSURE; DOCOSAHEXAENOIC ACIDS AB Greater fish oil consumption has been associated with reduced CVD risk, although the mechanisms are unclear. Plant-source oil omega-3 fatty acids (ALA) have also been studied regarding their cardiovascular effect. We conducted a systematic review of randomized controlled trials that evaluated the effect of consumption of fish oil and ALA on commonly measured serum CVD risk factors, performing meta-analyses when appropriate. Combining 21 trials evaluating lipid outcomes, fish oil consumption resulted in a summary net change in triglycerides of -27 (95% CI -33, -20) mg/dL, in HDL cholesterol of +1.6 (95% CI +0.8,+2.3) mg/dL, and in LDL cholesterol of +6 (95% CI +3,+8) mg/dL. There was no effect of fish oil on total cholesterol. Across studies, higher fish oil dose and higher baseline levels were associated with greater reductions in serum triglycerides. Overall, the 27 fish oil trials evaluating Hgb A(1c) or FBS found small non-significant net increases compared to control oils. Five studies of ALA were inconsistent in their effects on lipids, Hgb A(1c) or FBS. Four studies investigating the effects of omega-3 fatty acids on hs-CRP were also inconsistent and non-significant. The evidence supports a dose-dependent beneficial effect of fish oil on serum triglycerides, particularly among people with more elevated levels. Fish oil consumption also modestly improves HDL cholesterol, increases LDL cholesterol levels, but does not appear to adversely affect glucose homeostasis. The evidence regarding the effects of omega-3 fatty acids on hs-CRP is inconclusive, as are data on ALA. (c) 2006 Elsevier Ireland Ltd. All rights reserved. C1 Tufts Univ, New England Med Ctr, Evidence Based Practice Ctr, Inst Clin Res & Hlth Policy Studies, Boston, MA 02111 USA. Tufts Univ, Jean Mayer USDA Human Nutr Res Ctr Aging, Cardiovasc Nutr Lab, Boston, MA 02111 USA. C3 Tufts Medical Center; Tufts University; Tufts University; United States Department of Agriculture (USDA) RP Balk, EM (通讯作者)，Tufts Univ, New England Med Ctr, Evidence Based Practice Ctr, Inst Clin Res & Hlth Policy Studies, Box 63,750 Washington St, Boston, MA 02111 USA. 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1993, DIABETES CARE, V16, P683, DOI 10.2337/diacare.16.5.683 Woodman RJ, 2002, AM J CLIN NUTR, V76, P1007, DOI 10.1093/ajcn/76.5.1007 NR 92 TC 575 Z9 701 U1 0 U2 107 PU ELSEVIER IRELAND LTD PI CLARE PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND SN 0021-9150 EI 1879-1484 J9 ATHEROSCLEROSIS JI Atherosclerosis PD NOV PY 2006 VL 189 IS 1 BP 19 EP 30 DI 10.1016/j.atherosclerosis.2006.02.012 PG 12 WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease WE Science Citation Index Expanded (SCI-EXPANDED) SC Cardiovascular System & Cardiology GA 097SD UT WOS:000241467900003 PM 16530201 DA 2026-02-02 ER PT J AU Hartman, C Ben-Artzi, E Berkowitz, D Elhasid, R Lajterer, N Postovski, S Hadad, S Shamir, R AF Hartman, Corina Ben-Artzi, Elisheva Berkowitz, Drora Elhasid, Ronit Lajterer, Noah Postovski, Serghei Hadad, Salim Shamir, Raanan TI Olive oil-based intravenous lipid emulsion in pediatric patients undergoing bone marrow transplantation: A short-term prospective controlled trial SO CLINICAL NUTRITION LA English DT Article DE Bone marrow transplantation; Parenteral nutrition; Intravenous lipid emulsions; Olive oil-based lipid emulsions; MCT/LCT lipid emulsions; Children ID MEDIUM-CHAIN TRIGLYCERIDES; HOME PARENTERAL-NUTRITION; HIGH-DOSE CHEMOTHERAPY; PRETERM INFANTS; FATTY-ACIDS; MEDITERRANEAN DIET; PLASMA; PEROXIDATION; METABOLISM; EFFICACY AB Background: & aims: Parenteral nutrition (PN) is an important component of the supportive care of children undergoing bone marrow transplantation (BMT). The study aimed to assess short-term safety and metabolic effects of an olive oil-based (00) lipid emulsion compared with a MCT/LCT (M/L) emulsion in the clinical setting of pediatric BMT. Methods: Twenty-eight pediatric BMT patients (age 1-18 years) expected to need PN support for at least 2 weeks, were prospectively enrolled and randomly assigned to receive either 00 or M/L lipid emulsions within PN. Clinical and routine laboratory parameters, plasma fatty acids profile, vitamin E and peroxidation status were recorded at baseline and after 14 days of PN. Results: No significant differences were found for hematological parameters, liver enzymes, vitamins, plasma peroxidation status, percentage and time to engraftment. Taking into consideration the baseline fatty acids levels, the 00 group showed higher oleic acid (p = 0.012), linoleic (p = 0.012) and arachidonic acid (p = 0.002) enrichment but similar eicosapentanoic and docosahexanoic acids levels compared to the M/L group at day 14. Cholesterol levels decreased significantly in the 00 group after 14 days on PN (p = 0.017). Conclusions: 00 lipid emulsion was well tolerated, maintained essential fatty acids and peroxidation status, and generated a favorable plasma lipid profile. In this study short-term use of 00 intravenous lipid emulsions was safe in children who needed PN support during BMT. (C) 2009 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved. C1 [Hartman, Corina; Shamir, Raanan] Tel Aviv Univ, Sackler Fac Med, Schneider Childrens Med Ctr Israel, Inst Gastroenterol Nutr & Liver Dis, IL-69978 Tel Aviv, Israel. [Ben-Artzi, Elisheva] Bar Ilan Univ, Ramat Gan, Israel. [Ben-Artzi, Elisheva] Kinneret Acad Coll, Ramat Gan, Israel. [Berkowitz, Drora] Meyer Childrens Hosp, Pediat Gastroenterol & Nutr Unit, Haifa, Israel. [Elhasid, Ronit; Lajterer, Noah] Meyer Childrens Hosp, Bone Marrow Transplantat Unit, Pediat Hematol & Oncol Dept, Haifa, Israel. [Hadad, Salim] Serv Pharm, Haifa, Israel. C3 Tel Aviv University; Sackler Faculty of Medicine; Bar Ilan University; Kinneret Academic College; Rambam Health Care Campus; Rambam Health Care Campus RP Hartman, C (通讯作者)，Schneider Childrens Med Ctr Israel, Inst Gastroenterol Nutr & Liver Dis, 14 Kaplan St, IL-49202 Petah Tiqwa, Israel. EM corinahartman@gmail.com FU TEVA Pharmaceuticals Inc., Israel FX TEVA Pharmaceuticals Inc., Israel, supplied the parenteral nutrition solutions and partially supported the study. 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Nutr. PD DEC PY 2009 VL 28 IS 6 BP 631 EP 635 DI 10.1016/j.clnu.2009.04.021 PG 5 WC Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Nutrition & Dietetics GA 530HK UT WOS:000272579800006 PM 19497646 DA 2026-02-02 ER PT J AU Koopmans, SJ van Beusekom, HMM van der Staay, FJ Binnendijk, G Hulst, M Mroz, Z Ackermans, MT Benthem, L AF Koopmans, Sietse J. van Beusekom, Heleen M. M. van der Staay, F. Josef Binnendijk, Gisabeth Hulst, Marcel Mroz, Zlaw Ackermans, Mariette T. Benthem, Lambertus TI Beneficial effects of a plant-fish oil, slow carbohydrate diet on cardio-metabolic health exceed the correcting effects of metformin-pioglitazone in diabetic pigs fed a fast-food diet SO PLOS ONE LA English DT Article ID TRADITIONAL MEDITERRANEAN DIET; LIFE-STYLE INTERVENTION; INSULIN-RESISTANCE; INTESTINAL-MUCOSA; TYPE-2; ATHEROSCLEROSIS; PREVENTION; EXPRESSION; MELLITUS; GLUCOSE AB Background Lifestyle influences endocrine, metabolic and cardiovascular homeostasis. This study investigated the impact of diet and oral anti-diabetic medication on cardio-metabolic health in human-sized diabetic pigs. Methods After a growing pre-phase from similar to 30 to similar to 69 kg during which domestic pigs were fed either a low fat, low sucrose diet (group A) or a fast food-type diet elevated in lard (15%) and sucrose (40%) (group B), the pigs were subdivided in 5 groups (n = 7-8 pigs per group). Group 1, normal pigs from group A on a low fat, low sugar (L) pig diet and group 2, normal pigs from group B on a high lard (25%), sucrose-fructose (40%), cholesterol (1%) fast food-type (F) diet. Diabetes (D) was induced in group B pigs by streptozotocin and group 3 received the F diet (DF), group 4 received the F diet with Anti-diabetic medication metformin (2 g.day(-1) )pioglitazone (40 mg.day(-1)) (DFA) and group 5 switched to a Plant-Fish oil (25%), Slowly digestible starch (40%) diet (DPFS). The F and PFS diets were identical for fat, carbohydrate and protein content but only differed in fat and carbohydrate composition. The 5 pig groups were followed up for 7 weeks until reaching similar to 120 kg. Results In normal pigs, the F diet predisposed to several abnormalities related to metabolic syndrome. Diabetes amplified the inflammatory and cardiometabolic abnormalities of the F but both oral FA medication and the PFS diet partially corrected these abnormalities (mean +/- SEM) as follows: Fasting plasma TNF-alpha (pg.ml(-1)) and NEFA (mmol.l(-1)) concentrations were high (p<0.02) in DF (193 +/- 55 and 0.79 +/- 0.16), intermediate in DFA (136 +/- 40 and 0.57 +/- 012) and low in DPFS pigs (107 +/- 31 and 0.48 +/- 0.19). Meal intolerance (response over fasting) for glucose and triglycerides (area under the curve, mmol.h(-1)) and for lactate (3-h postprandial, mmol.l(-1)) was high (p<0.03) in DF (489 +/- 131, 8.6 +/- 4.8 and 2.2 +/- 0.6), intermediate in DFA (276 +/- 145, 1.4 +/- 1.1 and 1.6 +/- 0.4) and low in DPFS (184 +/- 62, 0.7 +/- 1.8 and 0.1 +/- 0.1). Insulin-mediated glucose disposal (mg.kg(-1).min(-1)) showed a numerical trend (p = NS): low in DF (6.9 +/- 2.2), intermediate in DFA (8.2 +/- 1.3) and high in DPFS pigs (10.4 +/- 2.7). Liver weight (g. kg(-1) body weight) and liver triglyceride concentration (g.kg(-1) liver) were high (p<0.001) in DF (23.8 +/- 2.0 and 69 +/- 14), intermediate in DFA (21.1 +/- 2.0 and 49 +/- 15) and low in DPFS pigs (16.4 +/- 0.7 and 13 +/- 2.0). Aorta fatty streaks were high (p<0.01) in DF (16.4 +/- 5.7%), intermediate in DFA (7.4 +/- 4.5%) and low in DPFS pigs (0.05 +/- 0.02%). Conclusion This translational study using pigs with induced type 2 diabetes provides evidence that a change in nutritional life style from fast food to a plant-fish oil, slowly digestible starch diet can be more effective than sole anti-diabetic medication. C1 [Koopmans, Sietse J.; Binnendijk, Gisabeth; Hulst, Marcel] Wageningen Univ & Res, Wageningen Livestock Res, Wageningen, Netherlands. [van Beusekom, Heleen M. M.] Erasmus MC, Expt Cardiol, Rotterdam, Netherlands. [van der Staay, F. Josef] Univ Utrecht, Fac Vet, Dept Farm Anim Hlth, Utrecht, Netherlands. [Hulst, Marcel] Wageningen Biovet Res, Lelystad, Netherlands. [Mroz, Zlaw] Univ Life Sci, Dept Anim Sci & Bioecon, Lublin, Poland. [Ackermans, Mariette T.] Amsterdam UMC, Clin Chem, Endocrine Lab, Location AMC, Amsterdam, Netherlands. [Benthem, Lambertus] Inorbit Therapeut AB, Gothenburg, Sweden. C3 Wageningen University & Research; Erasmus University Rotterdam; Erasmus MC; Utrecht University; Wageningen University & Research; University of Amsterdam RP Koopmans, SJ (通讯作者)，Wageningen Univ & Res, Wageningen Livestock Res, Wageningen, Netherlands. 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Other Topics GA YN0PH UT WOS:000746969100008 PM 34669714 OA Green Submitted, Green Accepted, gold DA 2026-02-02 ER PT J AU De Rosa, MC Caputo, M Zirpoli, H Rescigno, T Tarallo, R Giurato, G Weisz, A Torino, G Tecce, MF AF De Rosa, Maria Caterina Caputo, Mariella Zirpoli, Hylde Rescigno, Tania Tarallo, Roberta Giurato, Giorgio Weisz, Alessandro Torino, Gaetano Tecce, Mario Felice TI Identification of Genes Selectively Regulated in Human Hepatoma Cells by Treatment With Dyslipidemic Sera and PUFAs SO JOURNAL OF CELLULAR PHYSIOLOGY LA English DT Article ID POLYUNSATURATED FATTY-ACIDS; GLUTATHIONE S-TRANSFERASES; DIETARY ARACHIDONIC-ACID; MESSENGER-RNA EXPRESSION; DOCOSAHEXAENOIC-ACID; CARDIOVASCULAR-DISEASE; MEDITERRANEAN DIET; APOLIPOPROTEIN-M; PPAR-ALPHA; TRANSCRIPTION AB Serum composition is linked to metabolic diseases not only to understand their pathogenesis but also for diagnostic purposes. Quality and quantity of nutritional intake can affect disease risk and serum composition. It is then possible that diet derived serum components directly affect pathogenetic mechanisms. To identify involved factors, we evaluated the effect on gene expression of direct addition of dyslipidemic human serum samples to cultured human hepatoma cells (HepG2). Sera were selected on the basis of cholesterol level, considering this parameter as mostly linked to dietary intake. Cells were treated with 32 sera from hypercholesterolemic and normocholesterolemic subjects to identify differentially regulated mRNAs using DNA microarray analysis. We identified several mRNAs with the highest modulations in cells treated with dyslipidemic sera versus cells treated with normal sera. Since the two serum groups had variable polyunsaturated fatty acids (PUFAs) contents, selected mRNAs were further assessed for their regulation by docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA) and arachidonic acid (AA). Four genes resulted both affected by serum composition and PUFAs: 3-hydroxy-3-methylglutaryl-CoenzymeA synthase 2 (HMGCS2), glutathione S-transferase alpha 1 (GSTA1), liver expressed antimicrobial peptide 2 (LEAP2) and apolipoprotein M (ApoM). HMGCS2 expression appears the most relevant and was also found modulated via transcription factors peroxysome proliferator activated receptor (PPAR) and forkhead box O1 (FoxO1). Our data indicate that expression levels of the selected mRNAs, primarily of HMGCS2, could represent a reference of nutritional intake, PUFAs effects and dyslipidemic diseases pathogenesis. J. Cell. Physiol. 230: 2059-2066, 2015. (c) 2015 Wiley Periodicals, Inc. C1 [De Rosa, Maria Caterina; Caputo, Mariella; Zirpoli, Hylde; Rescigno, Tania; Torino, Gaetano; Tecce, Mario Felice] Univ Salerno, Dept Pharm, Lab Mol Nutr, I-84084 Fisciano, SA, Italy. [Tarallo, Roberta; Giurato, Giorgio; Weisz, Alessandro] Univ Salerno, Dept Med & Surg, Lab Mol Med & Genom, I-84084 Fisciano, SA, Italy. C3 University of Salerno; University of Salerno RP Tecce, MF (通讯作者)，Univ Salerno, Dipartimento Farm, Via Giovanni Paolo 2,132, I-84084 Fisciano, SA, Italy. EM tecce@unisa.it RI Giurato, Giorgio/K-3859-2018; Tarallo, Roberta/C-2600-2014; Weisz, Alessano/A-1317-2014; TECCE, Mario Felice/L-7295-2013 OI Giurato, Giorgio/0000-0002-0538-8978; Tarallo, Roberta/0000-0001-9668-3632; Weisz, Alessano/0000-0003-0455-2083; TECCE, Mario Felice/0000-0003-2355-6047 FU Universita di Salerno [FARB 2012, FARB 2013]; Ministero della Istruzione, Universita e Ricerca (MIUR) [PRIN 200832E9J9_003, 2010LC747T_002]; Consiglio Nazionale delle Ricerche (CNR); Flagship Project Interomics FX Contract grant sponsor: Universita di Salerno;Contract grant numbers: FARB 2012, FARB 2013.Contract grant sponsor: Ministero della Istruzione, Universita e Ricerca (MIUR);Contract grant numbers: PRIN 200832E9J9_003, 2010LC747T_002.Contract grant sponsor: Consiglio Nazionale delle Ricerche (CNR).Contract grant sponsor: Flagship Project Interomics. 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Cell. Physiol. PD SEP PY 2015 VL 230 IS 9 BP 2059 EP 2066 DI 10.1002/jcp.24932 PG 8 WC Cell Biology; Physiology WE Science Citation Index Expanded (SCI-EXPANDED) SC Cell Biology; Physiology GA CJ1HD UT WOS:000355233700007 PM 25639214 DA 2026-02-02 ER PT J AU Lin, LY Hsu, CY Chiou, HY Lee, HA Hsu, LM Chang, PY Kurniawan, AL Chao, JCJ AF Lin, Li-Yin Hsu, Chien-Yeh Chiou, Hung-Yi Lee, Hsiu-An Hsu, Li-Ming Chang, Po-Ya Kurniawan, Adi Lukas Chao, Jane C-J TI Association between Dietary Patterns and Serum Hepatic Enzyme Levels in Adults with Dyslipidemia and Impaired Fasting Plasma Glucose SO NUTRIENTS LA English DT Article DE dietary patterns; factor analysis; serum hepatic enzyme; dyslipidemia; impaired fasting plasma glucose; cross-sectional study; Taiwan ID FATTY LIVER-DISEASE; METABOLIC SYNDROME; RISK-FACTORS; NONALCOHOLIC STEATOHEPATITIS; ALANINE AMINOTRANSFERASE; MEDITERRANEAN DIET; ABDOMINAL OBESITY; OLDER-ADULTS; PREVALENCE; TAIWAN AB We investigated the association between dietary patterns and serum hepatic enzyme levels in adults with dyslipidemia and impaired fasting glucose in Taiwan. A total of 15,005 subjects (5452 men and 9553 women) aged 35-69 years were selected. Two major dietary patterns were identified by principal component analysis: Western dietary pattern and Mediterranean dietary pattern. Subjects in the highest quartile (Q4) of the Western dietary pattern showed an increased risk of elevated serum alanine aminotransferase (ALT) levels (OR: 1.24, 95% CI: 1.06-1.45, p-trend = 0.01). Fur-thermore, in the highest quartile of the Western dietary pattern, subjects with high waist circum-ference were observed to have a greater risk for developing abnormal serum ALT levels compared to those in the lowest quartile (Q1) (OR: 1.43, 95% CI: 1.04-1.97, p-trend = 0.01). In the highest quartile of the Western dietary pattern, only women were at an increased risk for having abnormal serum ALT levels (OR: 1.28, 95% CI: 1.04-1.59, p-trend = 0.03). By contrast, in the highest quartile of the Mediterranean dietary pattern, only men were at a reduced risk for having abnormal serum gamma-glutamyl transferase (GGT) levels (OR: 0.72, 95% CI: 0.53-0.97, p-trend = 0.048). We report a positive association between the Western dietary pattern and abnormal serum ALT levels. C1 [Lin, Li-Yin; Chao, Jane C-J] Taipei Med Univ, Coll Nutr, Sch Nutr & Hlth Sci, 250 Wu Hsing St, Taipei 11031, Taiwan. [Lin, Li-Yin; Chiou, Hung-Yi] Taipei Med Univ, Coll Publ Hlth, Master Program Appl Epidemiol, 250 Wu Hsing St, Taipei 11031, Taiwan. [Lin, Li-Yin; Chiou, Hung-Yi] Natl Hlth Res Inst, Inst Populat Hlth Sci, 35 Keyan Rd, Zhunan Town 35053, Miaoli County, Taiwan. [Hsu, Chien-Yeh] Natl Taipei Univ Nursing & Hlth Sci, Dept Informat Management, 365 Ming Te Rd, Taipei 11219, Taiwan. [Hsu, Chien-Yeh; Chao, Jane C-J] Taipei Med Univ, Coll Publ Hlth, Master Program Global Hlth & Dev, 250 Wu Hsing St, Taipei 11031, Taiwan. [Chiou, Hung-Yi] Taipei Med Univ, Coll Publ Hlth, Sch Publ Hlth, 250 Wu Hsing St, Taipei 11031, Taiwan. [Lee, Hsiu-An] Tamkang Univ, Dept Comp Sci & Informat Engn, 151 Yingzhuan Rd, New Taipei 25137, Taiwan. [Lee, Hsiu-An] Natl Hlth Res Inst, 35 Keyan Rd, Zhunan Town 35053, Miaoli County, Taiwan. [Hsu, Li-Ming] Taipei Vet Gen Hosp, Dept Internal Med, Yuanshan Suao Branch, 301 Sect 1,Subin Rd, Yilan 27047, Taiwan. [Chang, Po-Ya] Natl Taipei Univ Nursing & Hlth Sci, Dept Leisure Ind & Hlth Promot, 365 Ming Te Rd, Taipei 11219, Taiwan. [Kurniawan, Adi Lukas] Natl Taipei Univ Nursing & Hlth Sci, Res Ctr Healthcare Ind Innovat, 365 Ming Te Rd, Taipei 11219, Taiwan. [Chao, Jane C-J] Taipei Med Univ Hosp, Nutr Res Ctr, 252 Wu Hsing St, Taipei 11031, Taiwan. C3 Taipei Medical University; Taipei Medical University; National Health Research Institutes - Taiwan; National Taipei University of Nursing & Health Science (NTUNHS); Taipei Medical University; Taipei Medical University; Tamkang University; National Health Research Institutes - Taiwan; Taipei Veterans General Hospital; National Taipei University of Nursing & Health Science (NTUNHS); National Taipei University of Nursing & Health Science (NTUNHS); Taipei Medical University; Taipei Medical University Hospital RP Chao, JCJ (通讯作者)，Taipei Med Univ, Coll Nutr, Sch Nutr & Hlth Sci, 250 Wu Hsing St, Taipei 11031, Taiwan.; Chao, JCJ (通讯作者)，Taipei Med Univ, Coll Publ Hlth, Master Program Global Hlth & Dev, 250 Wu Hsing St, Taipei 11031, Taiwan.; Chao, JCJ (通讯作者)，Taipei Med Univ Hosp, Nutr Res Ctr, 252 Wu Hsing St, Taipei 11031, Taiwan. EM jlin11025@gmail.com; cyhsu@ntunhs.edu.tw; hychiou@tmu.edu.tw; billy72325@gmail.com; lmhsu@hotmail.com; pychang@ntunhs.edu.tw; 8lukas@ntunhs.edu.tw; chenjui@tmu.edu.tw RI ; Hsu, Chien-Yeh/OEP-2464-2025 OI Kurniawan, Adi Lukas/0000-0002-9809-1953; Lee, Hsiu-An/0000-0003-1178-1626; Chao, Jane/0000-0002-3610-9580 CR Abazarfard Z, 2016, IRAN RED CRESCENT ME, V18, DOI 10.5812/ircmj.23628 Ahmed Z, 2018, CLIN EXP GASTROENTER, V11, P301, DOI 10.2147/CEG.S160537 Al Rifai M, 2015, ATHEROSCLEROSIS, V239, P629, DOI 10.1016/j.atherosclerosis.2015.02.011 Amini M, 2010, NUTRITION, V26, P986, DOI 10.1016/j.nut.2010.03.006 Arefhosseini SR, 2011, HEALTH PROMOT PERSPE, V1, P147, DOI 10.5681/hpp.2011.016 Bellentani S, 2000, ANN INTERN MED, V132, P112, DOI 10.7326/0003-4819-132-2-200001180-00004 Brady CW, 2015, WORLD J GASTROENTERO, V21, P7613, DOI 10.3748/wjg.v21.i25.7613 Cai XL, 2016, NUTRIENTS, V8, DOI 10.3390/nu8040183 Chen CH, 2006, J CLIN GASTROENTEROL, V40, P745, DOI 10.1097/00004836-200609000-00016 Chitturi S, 2004, J GASTROEN HEPATOL, V19, P368, DOI 10.1111/j.1440-1746.2003.03252.x Souza Mônica Rodrigues de Araújo, 2012, Arq. 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However, such trials are expensive and time-consuming, and the results are limited to considerable individual differences. This is the first study to comprehensively investigate the effect of different oils on the lipid accumulation and reactive oxygen species (ROS) production in HepG2 cells by hydrolyzing oil to fatty acids with integrated fat content. In addition, the key components of fatty acid composition, phytosterol, polyphenols, and tocopherol/tocotrienol in different oils, contributing to a decrease in content of lipid accumulation, cholesterol, ROS, and malondialdehyde (MDA), were analyzed using multivariate analysis. The results showed that the lipid accumulation content of coconut oil, Pu'er tea oil, olive oil, and flaxseed oil at a concentration of 200 mu M decreased by 45.98 +/- 0.75, 50.35 +/- 1.37, 40.43 +/- 2.44, and 42.76 +/- 1.88%, respectively, compared with the lard. In addition, the ROS contents of Pu'er tea oil, olive oil, and flaxseed oil had no significant difference from that of control cells (p < 0.05). In the results, (3 beta,5 alpha)-stigmastan-3-yl, cholane-5,20(22)-diene-3b-ph, and beta-sitosterol were determined to be the key components in edible oils associated with lipid accumulation and ROS production. C1 [Li, Xiaojing; Wu, Gangcheng; Qi, Xiguang; Zhang, Hui; Wang, Li; Qian, Haifeng] Jiangnan Univ, State Key Lab Food Sci & Technol, Wuxi 214122, Peoples R China. [Li, Xiaojing; Wu, Gangcheng; Qi, Xiguang; Zhang, Hui; Wang, Li; Qian, Haifeng] Jiangnan Univ, Sch Food Sci & Technol, Wuxi 214122, Peoples R China. [Shen, Yingbin] Jinan Univ, Sch Sci & Engn, Dept Food Sci & Engn, Guangzhou 510632, Guangdong, Peoples R China. C3 Jiangnan University; Jiangnan University; Jinan University RP Zhang, H (通讯作者)，Jiangnan Univ, State Key Lab Food Sci & Technol, Wuxi 214122, Peoples R China.; Zhang, H (通讯作者)，Jiangnan Univ, Sch Food Sci & Technol, Wuxi 214122, Peoples R China. EM zhanghui@jiangnan.edu.cn OI Zhu, Ling/0000-0002-0756-9334; Shen, Yingbin/0000-0001-9767-1107 FU National Key Research and Development Project of China [2016YFD0401204]; National Natural Science Foundation of China [31671891] FX This research is financially supported by the National Key Research and Development Project of China (No. 2016YFD0401204) and National Natural Science Foundation of China (No. 31671891). 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Agric. Food Chem. PD NOV 14 PY 2018 VL 66 IS 45 BP 11943 EP 11956 DI 10.1021/acs.jafc.8b04563 PG 14 WC Agriculture, Multidisciplinary; Chemistry, Applied; Food Science & Technology WE Science Citation Index Expanded (SCI-EXPANDED) SC Agriculture; Chemistry; Food Science & Technology GA HB5LJ UT WOS:000451102000008 PM 30350970 DA 2026-02-02 ER PT J AU Kostapanos, MS Florentin, M Elisaf, MS Mikhailidis, DP AF Kostapanos, Michael S. Florentin, Matilda Elisaf, Moses S. Mikhailidis, Dimitri P. TI Hemostatic Factors and the Metabolic Syndrome SO CURRENT VASCULAR PHARMACOLOGY LA English DT Article DE Metabolic syndrome; hemostasis; endothelium; platelet; coagulation; fibrinolysis; viscosity ID PLASMINOGEN-ACTIVATOR INHIBITOR-1; MEAN PLATELET VOLUME; C-REACTIVE PROTEIN; CARDIOVASCULAR RISK-FACTORS; CORONARY-HEART-DISEASE; VON-WILLEBRAND-FACTOR; SERUM URIC-ACID; NONALCOHOLIC FATTY LIVER; ENDOTHELIUM-DEPENDENT VASODILATION; DENSITY-LIPOPROTEIN CHOLESTEROL AB Metabolic syndrome (MetS) is associated with increased risk of both atherothrombotic cardiovascular events and venous thromboembolism. The pro-thrombotic potential of MetS, may explain this association. In this review we discuss the relationship of MetS with hemostasis focusing on endothelial function, platelet activity, coagulation, fibrinolysis and hemorheologic markers. Endothelial-dependent vasodilatation is impaired in MetS. This is mostly mediated by a reduced expression of vasodilators (nitric oxide and prostacyclin) with a concomitant increase of vasoconstrictors (endothelin-1, angiotensin II and thromboxane A(2)). Platelet activity is enhanced in MetS. A cross-talk between activated endothelium and platelets results in a pro-thrombotic vicious cycle. Enhanced coagulation together with impaired fibrinolysis is also present in MetS. This is mirrored by high fibrinogen and plasminogen activator inhibitor-1 levels. Endothelial dysfunction, expressed by high von Willebrand factor and tissue plasminogen factor levels, also contributes to this abnormality. Whole blood and plasma viscosity is increased in MetS. Lifestyle intervention can improve the MetS-related pro-thrombotic state. These measures include weight reduction and improved composition of the diet. A Mediterranean-style diet rich in olive oil, as a source of monounsaturated fat, and low saturated fat consumption may also be beneficial. C1 [Kostapanos, Michael S.; Mikhailidis, Dimitri P.] UCL, Sch Med, Dept Clin Biochem, London NW3 2QG, England. [Kostapanos, Michael S.; Florentin, Matilda; Elisaf, Moses S.] Univ Ioannina, Sch Med, Dept Internal Med, GR-45110 Ioannina, Greece. C3 University of London; University College London; UCL Medical School; University of Ioannina RP Mikhailidis, DP (通讯作者)，UCL, Sch Med, Dept Clin Biochem, Royal Free Hosp Campus,Pond St, London NW3 2QG, England. EM mikhailidis@aol.com RI ; Mikhailidis, Dimitri/A-1869-2013; Kostapanos, Michalis/AAB-2411-2020 OI ELISAF, MOSES/0000-0003-0505-078X; Kostapanos, Michalis/0000-0002-7513-5319 FU MSD; Genzyme; Abbot; Astra-Zeneca FX This review was written independently. The authors did not receive financial or professional help with the preparation of the manuscript. DPM and MSE have given talks, attended conferences and participated in advisory boards and trials sponsored by various pharmaceutical companies (MSD, Genzyme, Abbot and Astra-Zeneca). 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1200 BR SHARJAH, U ARAB EMIRATES SN 1570-1611 EI 1875-6212 J9 CURR VASC PHARMACOL JI Current Vascular Pharmacology PD NOV PY 2013 VL 11 IS 6 BP 880 EP 905 DI 10.2174/15701611113116660171 PG 26 WC Pharmacology & Pharmacy; Peripheral Vascular Disease WE Science Citation Index Expanded (SCI-EXPANDED) SC Pharmacology & Pharmacy; Cardiovascular System & Cardiology GA AA4IC UT WOS:000331058300009 PM 24168445 DA 2026-02-02 ER PT J AU George, ES Daly, RM Tey, SL Brown, R Wong, THT Tan, SY AF George, Elena S. Daly, Robin M. Tey, Siew Ling Brown, Rachel Wong, Tommy Hon Ting Tan, Sze-Yen TI Perspective: Is it Time to Expand Research on "Nuts" to Include "Seeds"? Justifications and Key Considerations SO ADVANCES IN NUTRITION LA English DT Article DE nuts; seeds; nutrients; health; nutritional sciences; epidemiology; clinical study ID CORONARY-HEART-DISEASE; DIET QUALITY; TREE NUTS; NATIONAL-HEALTH; BLOOD-PRESSURE; CARDIOVASCULAR-DISEASE; INFLAMMATORY MARKERS; MEDITERRANEAN DIET; OIL CONSUMPTION; NUTRIENT INTAKE AB The health benefits of nuts reported throughout the literature are extensive and well established for reducing the risk of, and managing several chronic conditions such as cardiovascular disease, type 2 diabetes, nonalcoholic fatty liver disease, and cognition. Despite their comparable nutrient profile to nuts, seeds are often not assessed in clinical and epidemiological studies. Interestingly, dietary guidelines and recommendations often refer to "nuts and seeds" collectively, even though they are not consistently examined together in nutrition research when determining associated health benefits. The purpose of this review is to call for future nutrition research to consider combining nuts and seeds. This review provides justification for this proposal by summarizing current definitions for nuts and seeds and highlighting the similarities or dissimilarities in their nutrient compositions. Following this, we summarize current evidence on the health benefits of nuts and seeds, research gaps that should be addressed, and considerations for future research using both epidemiological and interventional study designs. Statement of Significance: This article proposes that future nut research should expand to include seeds, in order to support the development of specific recommendations for nuts and seeds as a food group, which is more aligned with the major dietary guidelines. C1 [George, Elena S.; Daly, Robin M.; Tan, Sze-Yen] Deakin Univ, Sch Exercise & Nutr Sci, Inst Phys Act & Nutr IPAN, Geelong, Vic, Australia. [Tey, Siew Ling; Brown, Rachel] Univ Otago, Dept Human Nutr, Dunedin, New Zealand. [Wong, Tommy Hon Ting] Univ Hong Kong, Li Ka Shing Fac Med, Sch Publ Hlth, Pok Fu Lam, Hong Kong, Peoples R China. C3 Deakin University; University of Otago; University of Hong Kong RP Tan, SY (通讯作者)，Deakin Univ, Sch Exercise & Nutr Sci, Inst Phys Act & Nutr IPAN, Geelong, Vic, Australia. 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Nutr. PD AUG 1 PY 2022 VL 13 IS 4 BP 1016 EP 1027 DI 10.1093/advances/nmac028 EA MAR 2022 PG 12 WC Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Nutrition & Dietetics GA 3K9AB UT WOS:000788202500001 PM 35333288 OA Green Submitted DA 2026-02-02 ER PT J AU Monserrat-Mesquida, M Bouzas, C García, S Quetglas-Llabrés, MM Mateos, D Ugarriza, L Gómez, C Sureda, A Tur, JA AF Monserrat-Mesquida, Margalida Bouzas, Cristina Garcia, Silvia Quetglas-Llabres, Maria Magdalena Mateos, David Ugarriza, Lucia Gomez, Cristina Sureda, Antoni Tur, Josep A. TI Carbon Dioxide (CO2) Dietary Emissions Are Related to Oxidative and Inflammatory Status in Adult Population SO NUTRIENTS LA English DT Article DE greenhouse gas emissions; oxidative stress; inflammation; biomarkers ID PROINFLAMMATORY CYTOKINES; TNF-ALPHA; STRESS; OBESITY; BLOOD; RISK; FAT AB Background: Carbon dioxide (CO2) is a primary greenhouse gas (GHG) causing global temperature to rise. Unsustainable diets induce an increment in the risk of obesity and noncommunicable diseases but also contribute to the global GSG burden. Objective: To assess whether CO2 dietary emissions influence the inflammatory and oxidative status of subjects with metabolic syndrome (MetS). Methods: As part of the PREDIMED-Plus study, 100 adults (55-75 years old) from the Balearic Islands, Spain, were recruited and classified according to their dietary CO2 emissions. Anthropometric parameters were determined, fasting blood samples were collected and plasma, neutrophils, and peripheral blood mononuclear cells (PBMCs) were obtained. Dietary inflammatory index (DII), adherence to a Mediterranean diet (ADM), fatty liver index (FLI), and estimated glomerular filtration (eGFR) were calculated. Clinical biochemical parameters, blood count, and oxidative stress and inflammatory biomarker levels were also determined. Results: DII was higher in participants with high dietary CO2 emissions. Adherence to the MedDiet was inversely associated with CO2 emissions. Malondialdehyde (MDA) levels were higher in urine and plasma samples from subjects with high dietary CO2 emissions. Reactive oxygen species (ROS) production by PBMCs was greater in participants with high CO2 emissions. Interleukin-15, resistin, and leptin plasma levels were increased in participants with high dietary CO2 emissions. Conclusion: Dietary CO2 emissions influence oxidative status and inflammation in relation to the increased prooxidative and proinflammatory status in PBMCs and plasma. These biomarkers were useful for monitoring diet sustainability and health. C1 [Monserrat-Mesquida, Margalida; Bouzas, Cristina; Garcia, Silvia; Quetglas-Llabres, Maria Magdalena; Mateos, David; Ugarriza, Lucia; Gomez, Cristina; Sureda, Antoni; Tur, Josep A.] Univ Balearic Isl IUNICS, Res Grp Community Nutr & Oxidat Stress, Palma De Mallorca 07122, Spain. [Monserrat-Mesquida, Margalida; Bouzas, Cristina; Garcia, Silvia; Quetglas-Llabres, Maria Magdalena; Mateos, David; Ugarriza, Lucia; Sureda, Antoni; Tur, Josep A.] Inst Salud Carlos III, CIBEROBN Physiopathol Obes & Nutr, Madrid 28029, Spain. [Monserrat-Mesquida, Margalida; Bouzas, Cristina; Garcia, Silvia; Quetglas-Llabres, Maria Magdalena; Mateos, David; Ugarriza, Lucia; Gomez, Cristina; Sureda, Antoni; Tur, Josep A.] Hlth Res Inst Balearic Isl IdISBa, Palma De Mallorca 07120, Spain. [Ugarriza, Lucia] IBSalut, CS Camp Redo, Palma De Mallorca 07010, Spain. [Gomez, Cristina] Univ Hosp Son Espases, Clin Anal Serv, Palma De Mallorca 07198, Spain. C3 Instituto de Salud Carlos III; CIBER - Centro de Investigacion Biomedica en Red; CIBEROBN; Institut Investigacio Sanitaria Illes Balears (IdISBa); Hospital Universitari Son Espases RP Tur, JA (通讯作者)，Univ Balearic Isl IUNICS, Res Grp Community Nutr & Oxidat Stress, Palma De Mallorca 07122, Spain.; Tur, JA (通讯作者)，Inst Salud Carlos III, CIBEROBN Physiopathol Obes & Nutr, Madrid 28029, Spain.; Tur, JA (通讯作者)，Hlth Res Inst Balearic Isl IdISBa, Palma De Mallorca 07120, Spain. EM margalida.monserrat@uib.es; pep.tur@uib.es RI ; Monserrat Mesquida, Margalida/AAB-4773-2019; Quetglas Llabrés, Maria Magdalena/AAA-4412-2019; Tur, Josep/AAE-5748-2020; Sureda, Antoni/N-9588-2019; Bouzas, Cristina/AAE-2069-2019 OI , Antoni/0000-0001-8656-6838; GOMEZ COBO, CRISTINA/0000-0002-9776-4730; García, Silvia/0000-0003-3534-1588; Bouzas Velasco, Cristina/0000-0002-1407-8461; Monserrat Mesquida, Margalida/0000-0002-8856-135X; Quetglas Llabrés, Maria Magdalena/0000-0003-4155-7780; Tur, Josep/0000-0002-6940-0761; FU Fundaci La Marat TV3; CIBEROBN is an initiative of Instituto de Salud Carlos III, Spain FX The authors especially thank the participants for their enthusiastic collaboration and the personnel for their outstanding support and exceptional efforts. CIBEROBN is an initiative of Instituto de Salud Carlos III, Spain. 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Fished in the Italian Southern Adriatic Sea SO GENES LA English DT Article DE Engraulis encrasicolus; anchovy; barcoding; traceability; flesh quality; chemical composition; fatty acid profile; nutritional value; seasonal variation; Adriatic Sea ID FATTY-ACID-COMPOSITION; SEASONAL-CHANGES; MARINE FISH; MUSCLE; LIVER; ENCRASICHOLUS; PROXIMATE; PROFILES; CAUGHT; COAST AB Background: Anchovies (Engraulis encrasicolus L.) are a component of the Mediterranean diet and among the most fished species. Despite Italian consumers showing a strong preference and willingness to pay more for locally caught anchovies, cases of mislabeling with non-local or different species have been documented. Molecular techniques like DNA barcoding offer reliable species identification, even in processed products, where morphological traits are no longer detectable. This pilot study applied a DNA barcoding technique targeting the mitochondrial cytochrome b gene to authenticate anchovies caught in the Italian Southern Adriatic Sea. Objectives: The study evaluated seasonal variations in the chemical and nutritional composition of anchovies, particularly the fatty acid profiles, highlighting their health benefits. Methods: During 2021, two fish samplings of anchovies were conducted per season from two fishing areas in Southern Adriatic Sea, one sample was used for mitochondrial DNA analyses, the other was used for morphometric measurements, physical, bromatological and chemical analyses. Results: Fish collected in summer showed higher total weight and edible yield relative to those fished in winter (p < 0.05). Anchovies fished in summer contained the highest concentration of proteins (p < 0.05) as compared to those caught during winter and autumn, while, in turn, they showed the highest amount of fat (p < 0.01). Fillets from anchovies fished during spring and summer contained a greater (p < 0.05) concentration of polyunsaturated fatty acids, and n-3 fatty acids than samples collected in autumn and winter. Conclusions: This study paves the way for further investigation to refine and validate the genetic identification and nutritional features of anchovies caught in the Italian Southern Adriatic Sea and marketed to consumers. C1 [De Virgilio, Maddalena; De Paola, Domenico] Natl Council Res, Inst Biosci & Bioresources, Via Amendola 165-A, I-70126 Bari, Italy. [Selvaggi, Maria; Ragni, Marco; Caputi Jambrenghi, Anna; Colonna, Maria Antonietta; Tarricone, Simona] Univ Bari Aldo Moro, Dept Soil Plant & Food Sci, Via Amendola 165-A, I-70125 Bari, Italy. [Carbonara, Claudia] Univ Foggia, Dept Med & Surg Sci, Via A Gramsci 89-91, I-71122 Foggia, Italy. [Giannico, Francesco] Univ Bari Aldo Moro, Dept Vet Med, I-70010 Valenzano, Italy. C3 Consiglio Nazionale delle Ricerche (CNR); Istituto di Bioscienze e Biorisorse (IBBR-CNR); Universita degli Studi di Bari Aldo Moro; University of Foggia; Universita degli Studi di Bari Aldo Moro RP Colonna, MA (通讯作者)，Univ Bari Aldo Moro, Dept Soil Plant & Food Sci, Via Amendola 165-A, I-70125 Bari, Italy.; Carbonara, C (通讯作者)，Univ Foggia, Dept Med & Surg Sci, Via A Gramsci 89-91, I-71122 Foggia, Italy. EM maddalena.devirgilio@cnr.it; domenico.depaola@cnr.it; maria.selvaggi@uniba.it; claudia.carbonara@unifg.it; marco.ragni@uniba.it; anna.caputijambrenghi@uniba.it; francesco.giannico@uniba.it; mariaantonietta.colonna@uniba.it; simona.tarricone@uniba.it RI Giannico, Francesco/B-6752-2013; Colonna, Maria Antonietta/AAZ-5469-2020; , claudia carbonara/OGO-7088-2025; Tarricone, Simona/AAM-9678-2020 OI De Paola, Domenico/0000-0001-5667-3114; Giannico, Francesco/0000-0003-4025-4956; Selvaggi, Maria/0000-0002-0817-9557; Colonna, Maria Antonietta/0000-0002-2222-2902; , claudia carbonara/0009-0005-5105-2243; Tarricone, Simona/0000-0003-4490-491X; FU Regione Puglia (ITALY)-Progetto FEAMP "Salvaguardia di piccoli pelagici: Una pesca sostenibile ed innovativa nel Basso Adriatico" (SALV.ADRI) [B91B17001140009] FX This work was supported by Regione Puglia (ITALY)-Progetto FEAMP "Salvaguardia di piccoli pelagici: Una pesca sostenibile ed innovativa nel Basso Adriatico" (SALV.ADRI); CUP: B91B17001140009. 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R. Freitas, J. E., Jr. Barletta, R. V. Maturana Filho, M. Gimenes, L. U. Vilela, F. G. Baruselli, P. S. Renno, F. P. TI Productive performance, nutrient digestion and metabolism of Holstein (Bos taurus) and Nellore (Bos taurus indicus) cattle and Mediterranean Buffaloes (Bubalis bubalis) fed with corn-silage based diets SO LIVESTOCK SCIENCE LA English DT Article DE Buffaloes; Cattle; Intake; Heifers; Xanthine ID MICROBIAL PROTEIN-PRODUCTION; RUMEN FERMENTATION; LIPOPROTEIN CHOLESTEROL; AMMONIA CONCENTRATION; RUMINAL PROTEIN; CARCASS TRAITS; WHEAT-STRAW; UREA LEVELS; RICE STRAW; IN-SITU AB The objective of this study was to evaluate the productive performance, nutrients digestion and metabolism of three different genetic groups fed with the same diet based on corn silage. 30 heifers in growth were used of three groups of cattle, the following: Nellore (Bos taurus indicus) (n = 10), Holstein (Bos taurus taurus) (n = 10), and Mediterranean buffaloes (Bubalis bubalis) (n = 10). The animals were fed in groups and received the same experimental diet composed of corn silage and concentrate for growing heifers. In the evaluation of animals the performance, consumption and total apparent digestibility of dry matter and nutrients with the aid of internal markers (chromic oxide) and external (iADF), rumen fermentation, excretion of purine derivatives, nitrogen balance and blood metabolites were measured. No differences were observed in animal performance. There were differences in nutrient intake and apparent digestibility of dry matter and nutrients in different groups of cattle. The concentration of ammonia nitrogen (NH3-N) and short chain fatty acids (SCFA) in the rumen were higher and lower, respectively, for the group of buffaloes in relation to other experimental groups evaluated. When considering the excretion of total purine derivatives, buffaloes showed the lowest value compared to other genetic groups evaluated; about 61.76% of the total genetic group Nellore and 57.62% of the total genetic group Holstein with an average of 33.67 mmol/day. For the buffaloes, the excretion of xanthine and hypoxanthine observed was of 5.11% of total purine derivatives. There was a better nitrogen balance (g/day) for groups of Holstein heifers and Nellore in relation to the group of buffalo heifers. There were differences in the concentrations of urea and urea nitrogen in serum and liver enzymes where the buffaloes had higher values in relation at the bovines. There is a great metabolic diversity among the experimental groups evaluated and it was more exacerbated among buffaloes and bovines, when submitted to the same diet and same management conditions. (C) 2011 Elsevier B.V. All rights reserved. C1 [Gandra, J. R.; Freitas, J. E., Jr.; Barletta, R. V.; Vilela, F. G.; Renno, F. P.] Univ Sao Paulo, Dept Nutr & Anim Prod, Sch Vet Med & Anim Sci, Pirassununga, SP, Brazil. [Maturana Filho, M.; Gimenes, L. U.; Baruselli, P. S.] Univ Sao Paulo, Dept Anim Reprod, Sch Vet Med & Anim Sci, Sao Paulo, Brazil. C3 Universidade de Sao Paulo; Universidade de Sao Paulo RP Gandra, JR (通讯作者)，Univ Sao Paulo, Dept Nutr & Anim Prod, Sch Vet Med & Anim Sci, Pirassununga, SP, Brazil. EM jeffersongandra@usp.br RI Barletta, Rafael/B-9621-2016; Baruselli, Pietro/C-7600-2012; Maturana Filho, Milton/IWE-5088-2023; Rennó, Francisco/C-5951-2012; Gana, Jefferson/T-3723-2017; GANA, JEFFERSON/T-3723-2017; Gimenes, Lindsay/B-6510-2013 OI Baruselli, Pietro/0000-0002-6773-4450; Rennó, Francisco/0000-0002-3275-3483; Gana, Jefferson/0000-0002-3287-8737; GANA, JEFFERSON/0000-0002-4134-5115; Gimenes, Lindsay/0000-0002-7644-675X CR ABDULLAH N, 1992, J AGR SCI-CAMBRIDGE, V119, P255, DOI 10.1017/S0021859600014180 Anand LN, 2008, LIVEST SCI, V115, P294, DOI 10.1016/j.livsci.2007.08.005 [Anonymous], 1980, NUTR REQ RUM LIV [Anonymous], 2001, Nutrient requirements of dairy cattle, V7th, P381 [Anonymous], 1999, OFFICIAL METHODS ANA, V16th [Anonymous], 2016, NUTR REQ BEEF CATTL, V8th, DOI DOI 10.17226/19014 BHATIA SK, 1992, INDIAN J ANIM SCI, V62, P364 CANESIN RC, 2010, ANN REUN BRAZ SOC AN, V32 Chen X.B., 1992, ESTIMATION MICROBIAL, P21 Chen XB, 1996, BRIT J NUTR, V75, P397, DOI 10.1079/BJN19960142 Chizzotti ML, 2007, REV BRAS ZOOTECN, V36, P138, DOI 10.1590/S1516-35982007000100017 de Freitas JE, 2010, CIENC RURAL, V40, P950, DOI 10.1590/S0103-84782010005000039 Detmann E, 2001, REV BRAS ZOOTECN, V30, P1600, DOI 10.1590/S1516-35982001000600030 Franzolin R, 2000, REV BRAS ZOOTECN, V29, P2109 Franzolin R, 2001, REV BRAS ZOOTECN, V30, P1872, DOI 10.1590/S1516-35982001000700025 Franzolin R, 2010, REV BRAS ZOOTECN, V39, P549, DOI 10.1590/S1516-35982010000300014 FRIEDEWALD WT, 1972, CLIN CHEM, V18, P499 Gandra J. 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PD SEP PY 2011 VL 140 IS 1-3 BP 283 EP 291 DI 10.1016/j.livsci.2011.04.005 PG 9 WC Agriculture, Dairy & Animal Science WE Science Citation Index Expanded (SCI-EXPANDED) SC Agriculture GA 809DI UT WOS:000294031600037 DA 2026-02-02 ER PT J AU Charlton, M AF Charlton, Michael TI Obesity, Hyperlipidemia, and Metabolic Syndrome SO LIVER TRANSPLANTATION LA English DT Article ID LIVER-TRANSPLANT RECIPIENTS; NONALCOHOLIC STEATOHEPATITIS; INSULIN-RESISTANCE; DISEASE; IMPROVEMENT; SURVIVAL; RISK AB 1. Obesity is increasingly common among liver transplantation (LT) recipients and donors. Outcomes following LT for selected patients with class I-III obesity are similar to those for nonobese recipients. In patients who are other-wise satisfactory candidates for LT, a high body mass index, as long as it does not present a technical barrier, should not be considered to be an absolute contraindication to LT. 2. The most common causes of death beyond the first year of LT are, in descending order of frequency, graft failure (especially secondary to hepatitis C virus recurrence), malignancy, cardiovascular disease, infections, and renal failure. Metabolic syndrome is an important risk factor for each of these etiologies of posttransplant death. Posttransplant diabetes, posttransplant hypertension, and an original diagnosis of cryptogenic cirrhosis, which is commonly associated with metabolic syndrome, are all associated with an increased risk of post-LT mortality. Features of metabolic syndrome should be screened for and treated in LT recipients. 3. Because of the physiological mechanism of post-LT hypertension, which includes renal arteriolar constriction secondary to calcineurin inhibition, calcium channel blocking agents are a good pharmacological treatment modality and have been shown to be effective in renal protection in randomized controlled trials of posttransplant hypertension. 4. It is rare for dietary changes and weight reduction to result in normalization of the lipid profile. Statins should thus be initiated early in the course of management of post-LT dyslipidemia. Forty milligrams of simvastatin per day, 40 mg of atorvastatin per day, and 20 mg of pravastatin per day are reasonable starting doses for post-LT hypercholesterolemia. It is important to remember that the effects of statin therapy are additive to those of a controlled diet (eg, a Mediterranean diet rich in omega-3 fatty acids, fruits, vegetables, and dietary fiber). 5. Nonalcoholic steatohepatitis, an increasingly common etiology of cirrhosis and liver failure, recurs commonly after LT and may also arise de novo. Treatment should be directed at managing obesity and complications of metabolic syndrome. Optimal immunosuppression in patients with nonalcoholic steatohepatitis is still evolving but should include steroid minimization. Liver Transpl 15:S83-S89, 2009. (C) 2009 AASLD. C1 [Charlton, Michael] Mayo Clin & Mayo Fdn, Dept Gastroenterol & Hepatol, Rochester, MN 55905 USA. C3 Mayo Clinic RP Charlton, M (通讯作者)，Mayo Clin, Transplant Ctr, CH-10,200 1st St SW, Rochester, MN 55905 USA. 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PD NOV PY 2009 VL 15 IS 11 SU 2 BP S83 EP S89 DI 10.1002/lt.21914 PG 7 WC Gastroenterology & Hepatology; Surgery; Transplantation WE Science Citation Index Expanded (SCI-EXPANDED) SC Gastroenterology & Hepatology; Surgery; Transplantation GA 517HS UT WOS:000271604600014 PM 19877024 OA Bronze DA 2026-02-02 ER PT J AU Cicero, AFG Fogacci, F Bove, M Veronesi, M Rizzo, M Giovannini, M Borghi, C AF Cicero, Arrigo F. G. Fogacci, Federica Bove, Marilisa Veronesi, Maddalena Rizzo, Manfredi Giovannini, Marina Borghi, Claudio TI Short-Term Effects of a Combined Nutraceutical on Lipid Level, Fatty Liver Biomarkers, Hemodynamic Parameters, and Estimated Cardiovascular Disease Risk: A Double-Blind, Placebo-Controlled Randomized Clinical Trial SO ADVANCES IN THERAPY LA English DT Article DE Cardiovascular disease risk; Dietary supplements; Endothelial dysfunction; L-Tyrosol; Nutraceuticals; Red yeast rice; Phytosterols ID RED YEAST RICE; INCIDENT METABOLIC SYNDROME; HEPATIC STEATOSIS INDEX; POPULATION-SAMPLE DATA; SERUM URIC-ACID; ACCUMULATION PRODUCT; CHOLESTEROL; GUIDELINES; STATEMENT; EFFICACY AB Introduction: There is a growing interest in nutraceuticals improving cardiovascular risk factor levels and related organ damage. Methods: This double-blind, placebo-controlled randomized clinical trial aims to compare the effect of a combined nutraceutical containing red yeast rice (10 mg), phytosterols (800 mg), and L-tyrosol (5 mg) on lipid profile, blood pressure, endothelial function, and arterial stiffness in a group of 60 patients with polygenic hypercholesterolemia resistant to Mediterranean diet. Results: After 8 weeks of treatment, when compared to the placebo group, the active treated patients experienced a more favorable percentage change in total cholesterol (-16.3% vs 9.9%, P < 0.001 always), LDL-C (-23.4% vs -13.2%, P < 0.001 always), and hepatic steatosis index (-2.8%, P < 0.01 vs -1.8%, P < 0.05). Moreover, ALT (-27.7%, P < 0.001), AST (-13.8%, P = 0.004), and serum uric acid (-12.3%, P = 0.005) were reduced by the tested nutraceutical compound both compared to randomization and to placebo, which did not affect these parameters (P < 0.01 for all). Regarding the hemodynamic parameters, there was a decrease of systolic blood pressure (-5.6%) with the active treatment not observed with placebo (P < 0.05 vs baseline and placebo) and endothelial reactivity improved, too (-13.2%, P < 0.001 vs baseline). Consequently, the estimated 10-year cardiovascular risk score improved by 1.19% (SE 0.4%) (P = 0.01) in the nutraceutical-treated patients. Conclusion: The tested nutraceutical association is able to improve the positive effects of a Mediterranean diet on a large number of CV risk factors and consequently of the estimated CV risk. C1 [Cicero, Arrigo F. G.; Fogacci, Federica; Bove, Marilisa; Veronesi, Maddalena; Giovannini, Marina; Borghi, Claudio] Univ Bologna, Dept Med & Surg Sci, Bologna, Italy. [Rizzo, Manfredi] Univ Palermo, Biomed Dept Internal Med & Med Specialties, Palermo, Italy. C3 University of Bologna; University of Palermo RP Cicero, AFG (通讯作者)，Univ Bologna, Dept Med & Surg Sci, Bologna, Italy. EM arrigo.cicero@unibo.it RI Fogacci, Federica/R-5931-2016; Giovannini, Marina/ITV-5674-2023; Cicero, Arrigo Francesco Giuseppe/H-8244-2019; Borghi, Claudio/K-2032-2016; RIZZO, MANFREDI/GZL-0551-2022 OI Fogacci, Federica/0000-0001-7853-0042; Cicero, Arrigo Francesco Giuseppe/0000-0002-4367-3884; FU University of Bologna Instutional; IBSA Farmaceutici (Milan, Italy) FX The study was supported by the University of Bologna Instutional funding. IBSA Farmaceutici (Milan, Italy) funded the article processing charges and open access fee. All named authors meet the International Committee of Medical Journal Editors (ICMJE) criteria for authorship for this manuscript, take responsibility for the integrity of the work as a whole, and have given final approval for the version to be published. IBSA Farmaceutici (Milan, Italy) provided the tested product and the related placebo. All authors had full access to all of the data in this study and take complete responsibility for the integrity of the data and accuracy of the data analysis. 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Ther. PD AUG PY 2017 VL 34 IS 8 BP 1966 EP 1975 DI 10.1007/s12325-017-0580-1 PG 10 WC Medicine, Research & Experimental; Pharmacology & Pharmacy WE Science Citation Index Expanded (SCI-EXPANDED) SC Research & Experimental Medicine; Pharmacology & Pharmacy GA FE3BQ UT WOS:000408091800013 PM 28687937 OA Green Submitted, hybrid DA 2026-02-02 ER PT J AU Wernicke, C Pohrt, A Pletsch-Borba, L Apostolopoulou, K Hornemann, S Meyer, N Machann, J Gerbracht, C Tacke, F Pfeiffer, AF Spranger, J Mai, KT AF Wernicke, Charlotte Pohrt, Anne Pletsch-Borba, Laura Apostolopoulou, Konstantina Hornemann, Silke Meyer, Nina Machann, Jurgen Gerbracht, Christiana Tacke, Frank Pfeiffer, Andreas F. H. Spranger, Joachim Mai, Knut TI Effect of unsaturated fat and protein intake on liver fat in people at risk of unhealthy aging: 1-year results of a randomized controlled trial SO AMERICAN JOURNAL OF CLINICAL NUTRITION LA English DT Article DE nonalcoholic fatty liver disease; magnetic resonance spectroscopy; dietary proteins; MUFA; PUFA; diet; healthy aging; non-Mediterranean population ID DIETARY; GLUCOSE; EPIDEMIOLOGY; INFLAMMATION; PREVALENCE; PLASMA AB Background: Short-term trials indicate improvement of intrahepatic lipids (IHLs) and metabolism by dietary protein or unsaturated fatty acids (UFAs) beyond weight loss. Objectives: We aimed to assess the effect of a dietary intervention high in protein and UFAs on IHLs and metabolic outcome after 12 mo, as long-term effects of such a combined intervention are unknown. Methods: Within a 36-mo randomized controlled trial, eligible subjects (aged 50 to 80 y, >= 1 risk factor for unhealthy aging) were randomly assigned to either intervention group (IG) with high intake of mono-/poly-UFAs [15-20 percent of total energy (%E)/10%-15%E, respectively], plant protein (15%- 25%E), and fiber (>= 30 g/d), or control group [CG, usual care, dietary recommendations of the German Nutrition Society (fat 30%E/carbohydrates 55%E/ protein 15%E)]. Stratification criteria were sex, known cardiovascular disease, heart failure, arterial hypertension, type 2 diabetes, and cognitive or physical impairment. Nutritional counseling and supplementation of foods mirroring the intended dietary pattern were performed in the IG. Diet-induced effects on IHLs, analyzed by magnetic resonance spectroscopy, as well as on lipid and glucose metabolism were predefined secondary endpoints. Results: IHL content was analyzed in 346 subjects without significant alcohol consumption at baseline and in 258 subjects after 12 mo. Adjusted for weight loss, sex, and age, we observed a comparable decline of IHLs in IG and CG (-33.3%; 95% CI: -49.3, -12.3%; n = 128 compared with-21.8%; 95% CI: -39.7, 1.5%; n = 130; P = 0.179), an effect that became significant by comparing adherent IG subjects to adherent CG subjects (-42.1%; 95% CI: -58.1, -20.1%; n = 88 compared with-22.2%; 95% CI: -40.7, 2.0%; n = 121; P = 0.013). Compared with the CG, decline of LDL cholesterol (LDL-C) and total cholesterol (TC) was stronger in the IG (for LDL-C P = 0.019, for TC P = 0.010). Both groups decreased in triglycerides and insulin resistance (P for difference between groups P = 0.799 and P = 0.124, respectively). Conclusions: Diets enriched with protein and UFAs have beneficial long-term effects on liver fat and lipid metabolism in adherent older subjects. This study was registered at the German Clinical Trials Register, https://www.drks.de/drks_web/setLocale_EN.do, DRKS00010049. Am J Clin Nutr 20XX;xx:xx-xx. C1 [Wernicke, Charlotte; Pohrt, Anne; Pletsch-Borba, Laura; Apostolopoulou, Konstantina; Meyer, Nina; Tacke, Frank; Pfeiffer, Andreas F. H.; Spranger, Joachim; Mai, Knut] Charite Univ Med Berlin, Berlin, Germany. [Wernicke, Charlotte; Pohrt, Anne; Pletsch-Borba, Laura; Apostolopoulou, Konstantina; Meyer, Nina; Tacke, Frank; Pfeiffer, Andreas F. H.; Spranger, Joachim; Mai, Knut] Free Univ Berlin, Berlin, Germany. [Wernicke, Charlotte; Pohrt, Anne; Pletsch-Borba, Laura; Apostolopoulou, Konstantina; Meyer, Nina; Tacke, Frank; Pfeiffer, Andreas F. H.; Spranger, Joachim; Mai, Knut] Humboldt Univ, Berlin, Germany. [Wernicke, Charlotte; Pletsch-Borba, Laura; Apostolopoulou, Konstantina; Meyer, Nina; Pfeiffer, Andreas F. H.; Spranger, Joachim; Mai, Knut] Berlin Inst Hlth, Dept Endocrinol & Metab, D-10117 Berlin, Germany. [Wernicke, Charlotte; Pletsch-Borba, Laura; Apostolopoulou, Konstantina; Hornemann, Silke; Meyer, Nina; Gerbracht, Christiana; Pfeiffer, Andreas F. H.; Spranger, Joachim; Mai, Knut] Nutri Act Competence Cluster Nutr Res Berlin, Potsdam, Germany. [Pohrt, Anne] Berlin Inst Hlth, Inst Biometry & Clin Epidemiol, Berlin, Germany. [Gerbracht, Christiana; Pfeiffer, Andreas F. H.] German Inst Human Nutr, Dept Clin Nutr, Potsdam, Germany. [Hornemann, Silke; Machann, Jurgen; Pfeiffer, Andreas F. H.] German Ctr Diabet Res, Neuherberg, Germany. [Machann, Jurgen] Univ Tubingen, Inst Diabet Res, Metab Dis IDM Helmholtz Ctr Munich, Tubingen, Germany. [Machann, Jurgen] Univ Hosp Tubingen, Dept Diagnost & Intervent Radiol, Sect Expt Radiol, Tubingen, Germany. [Tacke, Frank] Berlin Inst Hlth, Dept Hepatol & Gastroenterol, D-10117 Berlin, Germany. [Spranger, Joachim; Mai, Knut] DZHK German Ctr Cardiovasc Res, Partner Site Berlin, Berlin, Germany. C3 Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; Free University of Berlin; Humboldt University of Berlin; Humboldt University of Berlin; Free University of Berlin; Charite Universitatsmedizin Berlin; Berlin Institute of Health; Humboldt University of Berlin; Free University of Berlin; Charite Universitatsmedizin Berlin; Berlin Institute of Health; Leibniz Association; Deutsches Institut fur Ernahrungsforschung Potsdam-Rehbrucke (DIfE); German Center for Diabetes Research (DZD); Eberhard Karls University of Tubingen; Eberhard Karls University of Tubingen; Eberhard Karls University Hospital; Humboldt University of Berlin; Free University of Berlin; Charite Universitatsmedizin Berlin; Berlin Institute of Health; German Centre for Cardiovascular Research RP Spranger, J (通讯作者)，Charite Univ Med Berlin, Berlin, Germany.; Spranger, J (通讯作者)，Free Univ Berlin, Berlin, Germany.; Spranger, J (通讯作者)，Humboldt Univ, Berlin, Germany.; Spranger, J (通讯作者)，Berlin Inst Hlth, Dept Endocrinol & Metab, D-10117 Berlin, Germany.; Spranger, J (通讯作者)，DZHK German Ctr Cardiovasc Res, Partner Site Berlin, Berlin, Germany. EM joachim.spranger@charite.de RI Takahashi, Yoshinori/ACJ-7295-2022; Mai, Knut/W-9904-2019; Pfeiffer, Aneas F H/AAJ-2311-2020; Pletsch-Borba, Laura/AAG-2475-2020 OI Mai, Knut/0000-0003-0126-3155; Pfeiffer, Aneas F H/0000-0002-6887-0016; Meyer, Nina Marie Tosca/0000-0002-8208-0061; Pohrt, Anne/0000-0001-6104-622X; Pletsch-Borba, Laura/0000-0003-4872-6452 FU Competence Cluster Nutrition Research Berlin-Potsdam; Federal Ministry of Education and Research (BMBF) [01EA1408]; German Federal Ministry of Education and Research (BMBF) [01GI0925]; German Research Foundation[DFG] [CRC/TG 296] FX This work was supported by the Competence Cluster Nutrition Research Berlin-Potsdam, funded by the Federal Ministry of Education and Research (BMBF funding code 01EA1408). In addition, KM and JS were supported by a grant (01GI0925) from the German Federal Ministry of Education and Research (BMBF) to the German Center for Diabetes Research (DZD e.V.). JS and FT were supported by acollaborative research center of the German Research Foundation[DFG; CRC/TG 296 (Locotact)]. The funding source had no role in the design of this study and does not have any role during its execution, analyses, interpretation of the data, or decision to submit results CR Marin-Alejandre BA, 2019, NUTRIENTS, V11, DOI 10.3390/nu11102543 Bauer J, 2013, J AM MED DIR ASSOC, V14, P542, DOI 10.1016/j.jamda.2013.05.021 Bjermo H, 2012, AM J CLIN NUTR, V95, P1003, DOI 10.3945/ajcn.111.030114 Bortolotti M, 2009, AM J CLIN NUTR, V90, P1002, DOI 10.3945/ajcn.2008.27296 Bozzetto L, 2012, DIABETES CARE, V35, P1429, DOI 10.2337/dc12-0033 Coughlin JW, 2016, OBESITY, V24, P1046, DOI 10.1002/oby.21454 Cuthbertson DJ, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0050117 Deutsche Gesellschaft fur Ernahrung Osterreichische Gesellschaft fur Ernahrung Schweizerische Gesellschaft fur Ernahrungsforschung and Schweizerische Vereinigung fur Ernahrung, D A CH REF NEHRSL 2 European Association for the Study of the Liver (EASL), 2016, J Hepatol, V64, P1388, DOI 10.1016/j.jhep.2015.11.004 FREEDMAN LS, 1976, BIOMETRICS, V32, P691, DOI 10.2307/2529759 FRIEDEWALD WT, 1972, CLIN CHEM, V18, P499 Gannon MC, 2003, AM J CLIN NUTR, V78, P734, DOI 10.1093/ajcn/78.4.734 Gao C, 2020, LIPIDS HEALTH DIS, V19, DOI 10.1186/s12944-020-01214-w Gepner Y, 2019, J HEPATOL, V71, P379, DOI 10.1016/j.jhep.2019.04.013 Hooper L, 2015, COCHRANE DB SYST REV, DOI [10.1002/14651858.CD011737.pub2, 10.1002/14651858.CD011737] Imamura F, 2016, PLOS MED, V13, DOI 10.1371/journal.pmed.1002087 Kruse M, 2015, MOL NUTR FOOD RES, V59, P507, DOI 10.1002/mnfr.201400446 Linn T, 2000, DIABETOLOGIA, V43, P1257, DOI 10.1007/s001250051521 Luukkonen PK, 2018, DIABETES CARE, V41, P1732, DOI 10.2337/dc18-0071 Machann J, 2006, MAGN RESON MED, V55, P913, DOI 10.1002/mrm.20825 Markova M, 2017, GASTROENTEROLOGY, V152, P571, DOI 10.1053/j.gastro.2016.10.007 MATTHEWS DR, 1985, DIABETOLOGIA, V28, P412, DOI 10.1007/BF00280883 Meir AY, 2021, GUT, V70, P2085, DOI 10.1136/gutjnl-2020-323106 Perumpail BJ, 2017, WORLD J GASTROENTERO, V23, P8263, DOI 10.3748/wjg.v23.i47.8263 Pletsch-Borba L, 2021, CLIN NUTR, V40, P5457, DOI 10.1016/j.clnu.2021.09.022 Rees K, 2019, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD009825.pub3 Reynolds AN, 2020, PLOS MED, V17, DOI 10.1371/journal.pmed.1003053 Sacks FM, 2009, NEW ENGL J MED, V360, P859, DOI 10.1056/NEJMoa0804748 Szczepaniak LS, 2005, AM J PHYSIOL-ENDOC M, V288, pE462, DOI 10.1152/ajpendo.00064.2004 Vessby B, 2001, DIABETOLOGIA, V44, P312, DOI 10.1007/s001250051620 Wernicke C, 2020, MEDICINE, V99, DOI 10.1097/MD.0000000000022381 Wolfram G, 2015, ANN NUTR METAB, V67, P141, DOI [10.1159/000437243, 10.1159/00043724] Xu CC, 2020, LIVER INT, V40, P2982, DOI 10.1111/liv.14596 Xu J, 1999, J BIOL CHEM, V274, P23577, DOI 10.1074/jbc.274.33.23577 Yki-Järvinen H, 2021, NAT REV GASTRO HEPAT, V18, P770, DOI 10.1038/s41575-021-00472-y Younossi ZM, 2015, HEPATOLOGY, V62, p739A, DOI 10.1002/hep.28431 NR 36 TC 10 Z9 11 U1 3 U2 13 PU ELSEVIER SCIENCE INC PI NEW YORK PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA SN 0002-9165 EI 1938-3207 J9 AM J CLIN NUTR JI Am. J. Clin. Nutr. PD APR PY 2023 VL 117 IS 4 BP 785 EP 793 DI 10.1016/j.ajcnut.2023.01.010 EA APR 2023 PG 9 WC Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Nutrition & Dietetics GA D4MH7 UT WOS:000968484200001 PM 36804020 DA 2026-02-02 ER PT J AU Tian, MK Bai, YC Tian, HY Zhao, XB AF Tian, Mingke Bai, Yuchen Tian, Hongyu Zhao, Xuebing TI The Chemical Composition and Health-Promoting Benefits of Vegetable Oils-A Review SO MOLECULES LA English DT Review DE vegetable oil; chemical compositions; health effect; nutritional properties; functional ingredients; edible oils; diseases prevention ID FATTY-ACID-COMPOSITION; FLAXSEED OIL; SEED OIL; PHENOLIC-COMPOUNDS; GENE-EXPRESSION; PHYSICOCHEMICAL PROPERTIES; ANTIOXIDANT ACTIVITY; MEDITERRANEAN DIET; KERNEL OILS; RICE BRAN AB With population and economic development increasing worldwide, the public is increasingly concerned with the health benefits and nutritional properties of vegetable oils (VOs). In this review, the chemical composition and health-promoting benefits of 39 kinds of VOs were selected and summarized using Web of Science TM as the main bibliographic databases. The characteristic chemical compositions were analyzed from fatty acid composition, tocols, phytosterols, squalene, carotenoids, phenolics, and phospholipids. Health benefits including antioxidant activity, prevention of cardiovascular disease (CVD), anti-inflammatory, anti-obesity, anti-cancer, diabetes treatment, and kidney and liver protection were examined according to the key components in representative VOs. Every type of vegetable oil has shown its own unique chemical composition with significant variation in each key component and thereby illustrated their own specific advantages and health effects. Therefore, different types of VOs can be selected to meet individual needs accordingly. For example, to prevent CVD, more unsaturated fatty acids and phytosterols should be supplied by consuming pomegranate seed oil, flaxseed oil, or rice bran oil, while coconut oil or perilla seed oil have higher contents of total phenolics and might be better choices for diabetics. Several oils such as olive oil, corn oil, cress oil, and rice bran oil were recommended for their abundant nutritional ingredients, but the intake of only one type of vegetable oil might have drawbacks. This review increases the comprehensive understanding of the correlation between health effects and the characteristic composition of VOs, and provides future trends towards their utilization for the general public's nutrition, balanced diet, and as a reference for disease prevention. Nevertheless, some VOs are in the early stages of research and lack enough reliable data and long-term or large consumption information of the effect on the human body, therefore further investigations will be needed for their health benefits. C1 [Tian, Mingke; Bai, Yuchen; Tian, Hongyu] Beijing Technol & Business Univ, Beijing Key Lab Flavor Chem, Beijing 100048, Peoples R China. [Zhao, Xuebing] Tsinghua Univ, Key Lab Ind Biocatalysis, Minist Educ, Beijing 100084, Peoples R China. [Zhao, Xuebing] Tsinghua Univ, Inst Appl Chem, Dept Chem Engn, Beijing 100084, Peoples R China. C3 Beijing Technology & Business University; Tsinghua University; Tsinghua University RP Bai, YC (通讯作者)，Beijing Technol & Business Univ, Beijing Key Lab Flavor Chem, Beijing 100048, Peoples R China. EM baiyuchen@btbu.edu.cn; zhaoxb@mail.tsinghua.edu.cn RI Zhao, Xuebing/E-6301-2011; BAI, Yuchen/KPB-1532-2024 OI Zhao, Xuebing/0000-0002-4094-268X; Tian, Mingke/0009-0008-7717-1314; BAI, Yuchen/0000-0002-1934-1927 FU National Natural Science Foundation of China [32130083]; Ramp;D Program of Beijing Municipal Education Commission [KM202310011008] FX This research was funded by the National Natural Science Foundation of China, grant number 32130083 and R & D Program of Beijing Municipal Education Commission, grant number KM202310011008. 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Cereals Oils Foods, V23, P49 NR 141 TC 99 Z9 110 U1 13 U2 97 PU MDPI PI BASEL PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND EI 1420-3049 J9 MOLECULES JI Molecules PD SEP PY 2023 VL 28 IS 17 AR 6393 DI 10.3390/molecules28176393 PG 26 WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary WE Science Citation Index Expanded (SCI-EXPANDED) SC Biochemistry & Molecular Biology; Chemistry GA R0IS6 UT WOS:001061268500001 PM 37687222 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Rio-Aige, K Selma-Royo, M Massot-Cladera, M Everard, A Castell, M Rodríguez-Lagunas, MJ Collado, MC Pérez-Cano, FJ AF Rio-Aige, Karla Selma-Royo, Marta Massot-Cladera, Malen Everard, Amandine Castell, Margarida Rodriguez-Lagunas, Maria Jose Collado, Maria Carmen Perez-Cano, Francisco Jose TI A diet rich in fibre and vegetable protein during gestation and lactation shapes maternal immunity, intestinal microbiota and lipid metabolism SO EBIOMEDICINE LA English DT Article DE Maternal diet; Fibre; Vegetable protein; Gut microbiota; Mucosal immunity; Lipid metabolism ID GUT MICROBIOTA; BREAST-MILK; NUTRITION; MODEL; BROWN AB Background Establishing optimal maternal nutritional habits during pregnancy, breastfeeding, and early life is crucial for the health and welfare of both the mother and the child. However, research is lacking to understand the associated mechanisms linking maternal diet to health outcomes. The objective of this study was to assess the potential infl influence of two distinct diets, consumed during gestation and lactation, on the microbiota composition, immunity and lipid metabolism of Lewis dams. Methods Diet 1 (D1, Mediterranean diet-like) was characterized by a high fi fibre content, vegetable protein, and fi fish oil; whereas Diet 2 (D2, slightly Western diet-like) was enriched with animal protein and lard. Fecal samples were collected weekly throughout the nutritional intervention. Blood, tissue samples (adipose tissue, intestine, mammary gland, spleen and liver) and cecal content were collected from the mother at the end of lactation (day 21) to examine the effects on the epithelial barrier, lipid metabolism, microbiota composition and metabolites, as well as the mucosal immunity. Findings According to our fi findings, consumption of the D1 diet had a beneficial impact on the mothers compared to the D2 diet. D1 increased the intestinal surface area and enhanced the mucosal immunity, as evidenced by a rise in fecal immunoglobulin (Ig) A and Ig-coated bacteria levels, along with an increase in total IgG in the mesenteric lymph nodes, as well as elevated levels of T helper (Th)1-associated IgG2c isotype. Furthermore, D1 influenced the adiposity and exerted an anti-obesogenic effect on brown adipose tissue by up-regulating the expression of the genes Ucp-1, Cidea, Prdm16 and Gpr43. D1 also influenced the cecal microbiota composition, impacting its functions such as the production of short-chain fatty acids in the caecum. D1 reduced microbiota diversity by increasing beneficial taxa, such as Ruminococcaceae family and Turicibacter genus, among others. These genera showed correlations with the analysed immune and lipid metabolism parameters suggesting that microbiome modulation serves as a link between the observed systemic effects and the dietary intervention. Interpretation The study highlights that a diet rich in fi fibre, vegetable protein, and fi fish oil, consumed during gestation and lactation, enhances maternal health by improving intestinal function, mucosal immunity, and exerting antiobesogenic effects on lipid metabolism, likely mediated by modifications in the cecal microbiota composition and function. Funding The study was supported by LaMarat & oacute;-TV3 (DIM-2-ELI, ref. 2018-27/30-31). C1 [Rio-Aige, Karla; Massot-Cladera, Malen; Castell, Margarida; Rodriguez-Lagunas, Maria Jose; Perez-Cano, Francisco Jose] Univ Barcelona UB, Fac Pharm & Food Sci, Dept Biochem & Physiol, Physiol Sect, Barcelona, Spain. [Rio-Aige, Karla; Massot-Cladera, Malen; Castell, Margarida; Rodriguez-Lagunas, Maria Jose; Perez-Cano, Francisco Jose] Nutr & Food Safety Res Inst INSA UB, Santa Coloma De Gramenet, Spain. [Selma-Royo, Marta; Collado, Maria Carmen] CNR, Inst Agrochem & Food Technol IATA CSIC, Paterna, Spain. [Everard, Amandine] Catholic Univ Louvain, UCLouvain, Louvain Drug Res Inst, Metab & Nutr Res Grp, B-1200 Brussels, Belgium. [Everard, Amandine] WEL Res Inst WELRI, Walloon Excellence Life Sci & BIOtechnol WELBIO De, Ave Pasteur 6, B-1300 Wavre, Belgium. [Castell, Margarida] Inst Salud Carlos III, Ctr Invest Biomyd Red Fisiopatol Obes & Nutr CIBER, Madrid, Spain. C3 University of Barcelona; Consejo Superior de Investigaciones Cientificas (CSIC); Universite Catholique Louvain; Instituto de Salud Carlos III RP Castell, M (通讯作者)，Univ Barcelona UB, Fac Pharm & Food Sci, Dept Biochem & Physiol, Physiol Sect, Barcelona, Spain. EM mjrodriguez@ub.edu RI COLLADO, MARIA CARMEN/H-4924-2012; Selma Royo, Marta/GOH-3546-2022; Maria Jose, Roiguez-Lagunas/M-6958-2013; Perez-Cano, Francisco/G-6516-2019; Castell, Margarida/G-9078-2015; Rio, Karla/AAR-3890-2021 OI COLLADO, MARIA CARMEN/0000-0002-6204-4864; Selma Royo, Marta/0000-0002-4258-947X; Maria Jose, Roiguez-Lagunas/0000-0001-7870-8250; FU LaMarato-TV3 (DIM-2-ELI) [2018-27/30-31] FX The study was supported by LaMarato-TV3 (DIM-2-ELI, ref. 2018-27/30-31). 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A. F. van der Wolk, Suze C. Hutten, Barbara A. Daams, Joost G. Herrema, Hilde Nieuwdorp, Max TI A Systematic Review and Meta-analysis of Dietary Interventions Modulating Gut Microbiota and Cardiometabolic Diseases-Striving for New Standards in Microbiome Studies SO GASTROENTEROLOGY LA English DT Article DE Cardiometabolic Diseases; Dietary Intervention; Gut Microbiome; Metabolic Syndrome; Type 2 Diabetes ID CHAIN FATTY-ACIDS; LOW-GRADE INFLAMMATION; METABOLIC SYNDROME; CARDIOVASCULAR-DISEASE; INTESTINAL MICROBIOTA; MEDITERRANEAN DIET; INSULIN-RESISTANCE; BLOOD-PRESSURE; LIVER-DISEASE; OBESITY AB BACKGROUND & AIMS: Cardiometabolic diseases (CMDs) have shared properties and causes. Insulin resistance is a risk factor and characteristic of CMDs and has been suggested to be modulated by plasma metabolites derived from gut microbiota (GM). Because diet is among the most important modulators of GM, we performed a systematic review of the literature to assess whether CMDs can be modulated via dietary interventions targeting the GM. METHODS: A systematic review of the literature for clinical studies was performed on Ovid MEDLINE and Ovid Embase. Studies were assessed for risk of bias and patterns of intervention effects. A meta-analysis with random effects models was used to evaluate the effect of dietary interventions on clinical outcomes. RESULTS: Our search yielded 4444 unique articles, from which 15 randomized controlled trials and 6 nonrandomized clinical trials were included. The overall risk of bias was high in all studies. In general, most dietary interventions changed the GM composition, but no consistent effect could be found. Results of the meta-analyses showed that only diastolic blood pressure is decreased across interventions compared with controls (mean difference: -3.63 mm Hg; 95% confidence interval, -7.09 to -0.17; I-2 = 0%, P = .04) and that a high-fiber diet was associated with reduced triglyceride levels (mean difference: -0.69 mmol/L; 95% confidence interval, -1.36 to -0.02; I-2 = 59%, P = .04). Other CMD parameters were not affected. CONCLUSIONS: Dietary interventions modulate GM composition, blood pressure, and circulating triglycerides. However, current studies have a high methodological heterogeneity and risk of bias. Well-designed and controlled studies are thus necessary to better understand the complex interaction between diet, microbiome, and CMDs. C1 [Attaye, Ilias; Warmbrunn, Moritz, V; Boot, Aureline N. A. F.; van der Wolk, Suze C.; Herrema, Hilde; Nieuwdorp, Max] Amsterdam Univ Med Ctr, Dept Internal & Vasc Med, Locat AMC, Amsterdam, Netherlands. [Hutten, Barbara A.] Amsterdam Univ Med Ctr, Dept Epidemiol & Data Sci, Locat AMC, Amsterdam Cardiovasc Sci, Amsterdam, Netherlands. [Daams, Joost G.] Amsterdam Univ Med Ctr, Locat AMC, Med Lib, Amsterdam, Netherlands. RP Nieuwdorp, M (通讯作者)，Amsterdam UMC, Meibergdreef 9, NL-1105 AZ Amsterdam, Netherlands. EM m.nieuwdorp@amsterdamumc.nl RI ; Attaye, Ilias/ISS-7237-2023; Daams, Joost/P-1507-2018 OI Herrema, Hilde/0000-0002-0112-6348; Attaye, Ilias/0000-0001-9166-3229; FU Netherlands CardioVascular Research Committee (CVON) IN-CONTROL-II grant [2018-27]; Joint Programming Initiative a Healthy Diet for a Healthy Life (JPI HDHL) MICRODIET grant [5290510105]; ZonMw Vici grant 2020 [09150182010020]; Le Ducq consortium grant [17CVD01]; Senior Fellowship of the Dutch Diabetes Research Foundation [2019.82.004] FX Moritz V. Warmbrunn is supported by a Netherlands CardioVascular Research Committee (CVON) IN-CONTROL-II grant (2018-27) . Ilias Attaye is supported by a Joint Programming Initiative a Healthy Diet for a Healthy Life (JPI HDHL) MICRODIET grant (5290510105) . Max Nieuwdorp is supported by a ZonMw Vici grant 2020 [09150182010020] and a Le Ducq consortium grant 17CVD01. Hilde Herrema is supported by a Senior Fellowship of the Dutch Diabetes Research Foundation (2019.82.004) . 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GASTROENTEROLOGY JI Gastroenterology PD JUN PY 2022 VL 162 IS 7 BP 1911 EP 1932 DI 10.1053/j.gastro.2022.02.011 EA MAY 2022 PG 22 WC Gastroenterology & Hepatology WE Science Citation Index Expanded (SCI-EXPANDED) SC Gastroenterology & Hepatology GA 3H9IK UT WOS:000832341900020 PM 35151697 OA Green Submitted DA 2026-02-02 ER PT J AU Rodolfi, S Rurale, G Marelli, F Persani, L Campi, I AF Rodolfi, Simone Rurale, Giuditta Marelli, Federica Persani, Luca Campi, Irene TI Lifestyle Interventions to Tackle Cardiovascular Risk in Thyroid Hormone Signaling Disorders SO NUTRIENTS LA English DT Review DE resistance to thyroid hormone beta (RTH beta) and alpha (RTH alpha); monocarboxylate transporter 8 (MCT8) defects; selenoprotein deficiency; cardiovascular risk; lifestyle; physical exercise; nutrition; diet ID NONALCOHOLIC FATTY LIVER; SUBCLINICAL HYPOTHYROIDISM; MCT8 DEFICIENCY; RECEPTOR-ALPHA; GENERALIZED RESISTANCE; ATRIAL-FIBRILLATION; EXERCISE TOLERANCE; CLINICAL PHENOTYPE; AEROBIC EXERCISE; VITAMIN-E AB Thyroid hormones (THs) play a central role in cardiovascular and metabolic regulation, influencing lipid metabolism, insulin sensitivity and resting energy expenditure. Inherited disorders of impaired sensitivity to THs-including resistance to thyroid hormone alpha (RTH alpha) and beta (RTH beta), monocarboxylate transporter 8 (MCT8) deficiency and selenoprotein deficiency-lead to complex, multisystemic clinical features. Although these conditions are rare, with RTH beta being the most common and affecting about 1 in 20,000 newborns, they share clinical features with more prevalent thyroid disorders, such as hypothyroidism and hyperthyroidism, as well as neurological manifestations including muscle wasting and spasticity. These conditions present abnormal patterns of thyroid function and are associated with tissue-specific comorbidities such as arrhythmias, heart failure, dyslipidemia, hepatic steatosis, insulin resistance, and metabolic syndrome. To date, no targeted or controlled studies have evaluated the impact of lifestyle modifications in these patient populations. Therefore, this narrative review proposes plausible management strategies based on pathophysiological insights into the effects of thyroid hormones on target organs, combined with clinical reasoning and evidence extrapolated from related disorders. Physical exercise and diet may complement pharmacological treatments (e.g., levothyroxine or TRIAC) to improve cardiovascular and metabolic outcomes. In RTH beta, aerobic exercise enhances cardiovascular health, while a Mediterranean diet supports lipid control and glycemic parameters. In RTH alpha, physical exercise may aid neuromotor development, and a fluid-rich, fiber-moderated diet can alleviate constipation. In MCT8 deficiency, physiotherapy may improve mobility and relieve contractures, while nutritional support (e.g., feeding tube, gastrostomy) can be necessary to tackle feeding difficulties and reduce pulmonary complications. In selenoprotein deficiency, low-to-moderate physical exercise and an antioxidant-rich diet may protect against oxidative stress at several tissue levels. Although quantitative evidence is limited, this narrative review synthesizes current insights, providing a meaningful basis for future validation and research. C1 [Rodolfi, Simone; Persani, Luca] Univ Milan, Dept Med Biotechnol & Translat Med, I-20122 Milan, Italy. [Rurale, Giuditta; Marelli, Federica; Persani, Luca; Campi, Irene] IRCCS Ist Auxol Italiano, Dept Endocrine & Metab Dis, I-20100 Milan, Italy. C3 University of Milan; IRCCS Istituto Auxologico Italiano RP Persani, L (通讯作者)，Univ Milan, Dept Med Biotechnol & Translat Med, I-20122 Milan, Italy.; Persani, L; Campi, I (通讯作者)，IRCCS Ist Auxol Italiano, Dept Endocrine & Metab Dis, I-20100 Milan, Italy. EM simone.rodolfi@unimi.it; federica.marelli.fm@gmail.com; luca.persani@unimi.it; i.campi@auxologico.it RI ; Persani, Luca/B-6543-2008; Rurale, Giuditta/AAB-9931-2019; Campi, Irene/AAB-1335-2019; Marelli, Federica/B-2699-2019 OI Rodolfi, Simone/0009-0003-5117-3825; Persani, Luca/0000-0003-2068-9581; FU Italian Ministry of Health; Italian Ministry of Health, Rome-Ricerca Corrente FX This work was funded by Italian Ministry of Health, Rome-Ricerca Corrente. 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P526, DOI 10.20452/pamw.14876 Ylli D, 2019, J CLIN ENDOCR METAB, V104, P209, DOI 10.1210/jc.2018-01997 Zybek-Kocik A, 2018, CLIN ENDOCRINOL, V88, P460, DOI 10.1111/cen.13527 NR 169 TC 2 Z9 2 U1 4 U2 4 PU MDPI PI BASEL PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND EI 2072-6643 J9 NUTRIENTS JI Nutrients PD JUN 20 PY 2025 VL 17 IS 13 AR 2053 DI 10.3390/nu17132053 PG 26 WC Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Nutrition & Dietetics GA 4TK9Y UT WOS:001526252400001 PM 40647159 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Barrea, L Muscogiuri, G Pugliese, G de Alteriis, G Colao, A Savastano, S AF Barrea, Luigi Muscogiuri, Giovanna Pugliese, Gabriella de Alteriis, Giulia Colao, Annamaria Savastano, Silvia TI Metabolically Healthy Obesity (MHO) vs. Metabolically Unhealthy Obesity (MUO) Phenotypes in PCOS: Association with Endocrine-Metabolic Profile, Adherence to the Mediterranean Diet, and Body Composition SO NUTRIENTS LA English DT Article DE metabolically healthy obesity (MHO); metabolically unhealthy obesity (MUO); PCOS; mediterranean diet; body composition; phase angle; nutritionist ID POLYCYSTIC-OVARY-SYNDROME; VISCERAL ADIPOSITY INDEX; BIOELECTRICAL-IMPEDANCE ANALYSIS; CLINICAL SEVERITY; PHASE-ANGLE; RISK; WOMEN; CONSUMPTION; NUTRITION; MORTALITY AB Obesity and obesity-related low-grade inflammation are common findings in polycystic ovary syndrome (PCOS), the most common endocrine-metabolic disorder-affecting women in reproductive age. The terms metabolically healthy obese (MHO), and metabolically unhealthy obese (MUO) have been introduced to define individuals with obesity in whom cardio-metabolic risk factors are absent or present, respectively. To date, evidence investigating differences in body composition and adherence to the Mediterranean diet (MD) between MHO and MUO-PCOS women are lacking. Aim of this study was to better characterize the determinants of the metabolic health status in PCOS patients with obesity according to MHO and MUO phenotypes by evaluating endocrine-metabolic profile, inflammatory status, adherence to the MD, and body composition. The study population consisted of 94 treatment-naive women with PCOS and obesity (BMI = 38.23 & PLUSMN; 6.62 kg/m(2) and age = 24.12 & PLUSMN; 3.68 years). Compared PCOS MHO with PCOS MUO patients, the latter had higher levels of high-sensitivity C-reactive protein (hs-CRP) (p < 0.001), testosterone (p < 0.001), and insulin (p < 0.001), worse metabolic parameters, and higher Homeostatic Model Assessment of Insulin Resistance (HoMA-IR), Visceral Adiposity Index (VAI), and Fatty liver Index (FLI) (p < 0.001). Furthermore, PCOS MUO patients had lower adherence to the MD (p < 0.001) in spite of the same total energy intake (p = 0.102) as compared to PCOS MHO. The presence of MUO was associated with highest hs-CRP levels (OR = 1.49, p < 0.001), more severe hyperandrogenism and cardio-metabolic indices (p < 0.001). On the contrary, being PCOS MUO was associated with lower adherence to the MD (OR = 0.28, p < 0.001), and smaller PhAs (OR = 0.04, p < 0.001). Using a regression linear analysis model PREDIMED score entered at the first step (p < 0.001), followed by VAI (p < 0.001), and FLI (p = 0.032) in this analysis. At ROC analysis, a PREDIMED score of & LE;4 (p < 0.001, AUC 0.926) could serve as a threshold for a significantly increased risk of presence the MUO-PCOS phenotype. To the best of our knowledge, this is the first study that characterized MHO and MUO-PCOS women on the basis of their adherence to the MD, body composition, and cardio-metabolic indices, providing evidence of the usefulness of adjunctive diagnostic parameters to better differentiate the MHO/MHO phenotypes in this cohort of PCOS patients with obesity. C1 [Barrea, Luigi] Univ Telemat Pegaso, Ctr Direz, Dipartimento Sci Umanist, Via Porzio,Isola F2, I-80143 Naples, Italy. [Barrea, Luigi; Muscogiuri, Giovanna; Pugliese, Gabriella; Colao, Annamaria; Savastano, Silvia] Univ Federico II, Dept Clin Med & Surg, Endocrinol Unit, Ctr Italiano Cura & Benessere Paziente Obesita CI, Via Sergio Pansini 5, I-80131 Naples, Italy. [Muscogiuri, Giovanna; Pugliese, Gabriella; de Alteriis, Giulia; Colao, Annamaria; Savastano, Silvia] Univ Naples Federico II, Med Sch Naples, Dipartimento Med Clin & Chirurgia, Unit Endocrinol, Via Sergio Pansini 5, I-80131 Naples, Italy. [Muscogiuri, Giovanna; Colao, Annamaria] Univ Federico II, Cattedra Unesco Educ Alla Salute & Allo Sviluppo, I-80131 Naples, Italy. C3 Pegaso Online University; University of Naples Federico II; University of Naples Federico II; University of Naples Federico II RP Barrea, L (通讯作者)，Univ Telemat Pegaso, Ctr Direz, Dipartimento Sci Umanist, Via Porzio,Isola F2, I-80143 Naples, Italy.; Barrea, L (通讯作者)，Univ Federico II, Dept Clin Med & Surg, Endocrinol Unit, Ctr Italiano Cura & Benessere Paziente Obesita CI, Via Sergio Pansini 5, I-80131 Naples, Italy. 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Li, Xiang Krohn, Knut Ziesche, Stefanie Ceglarek, Uta Bluher, Matthias Keller, Maria Meir, Anat Yaskolka Heianza, Yoriko Kovacs, Peter Shai, Iris Qi, Lu TI Circulating Levels of microRNA-122 and Hepatic Fat Change in Response to Weight-Loss Interventions: CENTRAL Trial SO JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM LA English DT Article DE microRNA-122; hepatic fat; weight-loss interventions; randomized controlled trial ID IN-VIVO; MIR-122; EXPRESSION; PATHOGENESIS; SIGNATURE; SERUM; NAFLD; RNAS AB Purpose Little is known about the relations between changes in circulating microRNA-122 (miR-122) and liver fat in response to weight-loss interventions. We aimed to investigate the association between miR-122 and changes of hepatic fat content during 18-month diet and physical activity interventions. Methods The CENTRAL trial is an 18-month randomized, controlled trial among adults with abdominal obesity or dyslipidemia. Subjects were randomly assigned to a low-fat diet or a Mediterranean/low-carbohydrate diet. After 6 months of dietary intervention, each diet group was further randomized into added physical activity groups or no added physical activity groups for the following 12 months of intervention. The current study included 220 participants at baseline and 134 participants with repeated measurements on serum miR-122 and hepatic fat content over 18 months. Results Serum miR-122 significantly increased from baseline to 18 months, while no difference was observed across the 4 intervention groups. We found a significant association between miR-122 and hepatic fat content at baseline, as per unit increment in log-transformed miR-122 was associated with 3.79 higher hepatic fat content (P < 0.001). Furthermore, we found that higher elevations in miR-122 were associated with less reductions in hepatic fat percentage during 18-month interventions (beta = 1.56, P = 0.002). We also found a significant interaction between changes in miR-122 and baseline fasting plasma glucose with hepatic fat content changes in 18 months (P interaction = 0.02). Conclusions Our data indicate that participants with higher elevation in serum miR-122 may benefit less in reduction of hepatic fat content in response to diet and physical activity interventions. C1 [Wang, Mengying] Peking Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Beijing, Peoples R China. [Wang, Mengying; Xue, Qiaochu; Li, Xiang; Heianza, Yoriko; Qi, Lu] Tulane Univ, Sch Publ Hlth & Trop Med, Dept Epidemiol, New Orleans, LA 70112 USA. [Krohn, Knut] Univ Leipzig, Med Fac, Core Unit DNA Technol, Leipzig, Germany. [Ziesche, Stefanie; Bluher, Matthias; Keller, Maria; Kovacs, Peter] Univ Leipzig, Med Dept Endocrinol 3, Rheumatol, Nephrol,Med Ctr, Leipzig, Germany. [Ceglarek, Uta] Univ Leipzig, Inst Lab Med Clin Chem & Mol Diagnost, Med Ctr, Leipzig, Germany. [Bluher, Matthias; Keller, Maria] Univ Leipzig, Helmholtz Inst Metab Obes & Vasc Res HIMAG, Helmholtz Ctr Munich, Leipzig, Germany. [Bluher, Matthias; Keller, Maria] Univ Hosp Leipzig, Leipzig, Germany. [Meir, Anat Yaskolka; Shai, Iris] Ben Gurion Univ Negev, Fac Hlth Sci, Beer Sheva, Israel. [Qi, Lu] Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA. C3 Peking University; Tulane University; Leipzig University; Leipzig University; Leipzig University; Leipzig University; Helmholtz Association; Helmholtz-Center Munich - German Research Center for Environmental Health; Leipzig University; Ben-Gurion University of the Negev; Harvard University; Harvard T.H. Chan School of Public Health RP Qi, L (通讯作者)，Tulane Univ, Sch Publ Hlth & Trop Med, Dept Epidemiol, New Orleans, LA 70112 USA. EM 1qil@tulane.edu RI li, xiang/ABE-7253-2020; Ceglarek, Uta/GOE-5561-2022; Keller, Maria/AAD-4877-2020; Meir, Anat/AAK-7469-2021; Kovacs, Peter/KCK-1454-2024; Shai, Iris/HJO-8533-2023 OI Kovacs, Peter/0000-0002-0290-5423; Shai, Iris/0000-0001-9050-4605 FU National Heart, Lung, and Blood Institute [HL071981, HL034594, HL126024]; National Institute of Diabetes and Digestive and Kidney Diseases [DK115679, DK091718, DK100383, DK078616]; Fogarty International Center [TW010790]; American Heart Association Scientist Development Award [0730094N]; National Institute of General Medical Sciences [P20GM109036]; China Postdoctoral Science Foundation [BX2021021]; National Institute of Diabetes and Digestive and Kidney Diseases [UM1DK078616, R01DK115679] Funding Source: NIH RePORTER; National Institute of General Medical Sciences [P20GM109036] Funding Source: NIH RePORTER FX This work was supported by grants from the National Heart, Lung, and Blood Institute (HL071981, HL034594, HL126024), the National Institute of Diabetes and Digestive and Kidney Diseases (DK115679, DK091718, DK100383, DK078616), and the Fogarty International Center (TW010790). L.Q. is a recipient of the American Heart Association Scientist Development Award (0730094N). L.Q. is also supported by the National Institute of General Medical Sciences (P20GM109036). The study is also funded by China Postdoctoral Science Foundation (BX2021021). 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TI The relationship between sugar-sweetened beverages and liver enzymes among healthy premenopausal women: a prospective cohort study SO EUROPEAN JOURNAL OF NUTRITION LA English DT Article DE Liver enzymes; Menstrual cycle; Fructose; Dietary sucrose; Sugar-sweetened beverages ID FRUCTOSE CONSUMPTION; METABOLIC SYNDROME; DIETARY FRUCTOSE; FATTY; DISEASE; ADULTS; US AB To prospectively assess the association between sugar-sweetened beverages (SSB), added sugar, and total fructose and serum concentrations of liver enzymes among healthy, reproductive-age women. A prospective cohort of 259 premenopausal women (average age 27.3 +/- A 8.2 years; BMI 24.1 +/- A kg/m(2)) were followed up for up to two menstrual cycles, providing up to eight fasting blood specimens/cycle and four 24-h dietary recalls/cycle. Women with a history of chronic disease were excluded. Alanine and aspartate aminotransferases (ALT and AST, respectively) were measured in serum samples. Linear mixed models estimated associations between average SSB, added sugar, and total fructose intake and log-transformed liver enzymes adjusting for age, race, body mass index, total energy and alcohol intake, and Mediterranean diet score. For every 1 cup/day increase in SSB consumption and 10 g/day increase in added sugar and total fructose, log ALT increased by 0.079 U/L (95 % CI 0.022, 0.137), 0.012 U/L (95 % CI 0.002, 0.022), and 0.031 (0.012, 0.050), respectively, and log AST increased by 0.029 U/L (-0.011, 0.069), 0.007 U/L (0.000, 0.014), and 0.017 U/L (0.004, 0.030), respectively. Women who consumed a parts per thousand yen1.50 cups/day (12 oz can) SSB versus less had 0.127 U/L (95 % CI 0.001, 0.254) higher ALT [percent change 13.5 % (95 % CI 0.1, 28.9)] and 0.102 (95 % CI 0.015, 0.190) higher AST [percent change 10.8 % (95 % CI 1.5, 20.9)]. Sugar-sweetened beverages were associated with higher serum ALT and AST concentrations among healthy premenopausal women, indicating that habitual consumption of even moderate SSB may elicit hepatic lipogenesis. C1 [Shimony, Maya K.; Schliep, Karen C.; Schisterman, Enrique F.; Ahrens, Katherine A.; Sjaarda, Lindsey A.; Perkins, Neil J.; Mumford, Sunni L.] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Epidemiol Branch, Div Intramural Populat Hlth Res, NIH, 6100 Execut Blvd,7B03M, Rockville, MD 20852 USA. [Shimony, Maya K.] George Washington Univ, Sch Publ Hlth, Milken Inst, Dept Epidemiol & Biostat, Washington, DC USA. [Rotman, Yaron] NIDDK, Liver Dis Branch, NIH, Rockville, MD USA. [Pollack, Anna Z.] George Mason Univ, Coll Hlth & Human Serv, Dept Global & Community Hlth, Fairfax, VA 22030 USA. [Wactawski-Wende, Jean] SUNY Buffalo, Dept Epidemiol & Environm Hlth, Sch Publ Hlth & Hlth Profess, Buffalo, NY 14260 USA. C3 National Institutes of Health (NIH) - USA; NIH Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD); George Washington University; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK); George Mason University; State University of New York (SUNY) System; University at Buffalo, SUNY RP Mumford, SL (通讯作者)，Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Epidemiol Branch, Div Intramural Populat Hlth Res, NIH, 6100 Execut Blvd,7B03M, Rockville, MD 20852 USA. EM mumfords@mail.nih.gov RI Rotman, Yaron/AAK-8032-2020; Wactawki-Wende, Jean/AGH-5457-2022; Pollack, Anna/L-7652-2018; Schliep, Karen/A-2803-2012 OI Rotman, Yaron/0000-0002-7549-8216; Schisterman, Enrique/0000-0003-3757-641X; Mumford, Sunni Lyn/0000-0003-0133-3176; Ahrens, Katherine/0000-0001-5139-9208; Sjaarda, Lindsey/0000-0003-0539-8110; Wactawki-Wende, Jean/0000-0003-3096-9595; Pollack, Anna/0000-0002-4313-3298; Perkins, Neil/0000-0002-6802-4733; FU Eunice Kennedy Shriver National Institute of Child Health and Human Development [ZIAHD008762] Funding Source: NIH RePORTER; National Institute of Diabetes and Digestive and Kidney Diseases [ZIADK075013] Funding Source: NIH RePORTER; Intramural NIH HHS [Z01 HD008762, ZIA HD008761, ZIA HD008762] Funding Source: Medline CR Abdelmalek MF, 2010, HEPATOLOGY, V51, P1961, DOI 10.1002/hep.23535 [Anonymous], SEMIN LIVER DIS Basaranoglu M, 2013, WORLD J GASTROENTERO, V19, P1166, DOI 10.3748/wjg.v19.i8.1166 Chambers JC, 2011, NAT GENET, V43, P1131, DOI 10.1038/ng.970 Chiu S, 2014, EUR J CLIN NUTR, V68, P416, DOI 10.1038/ejcn.2014.8 Choi Hyon K., 2010, JAMA (Journal of the American Medical Association), V304, P2270, DOI 10.1001/jama.2010.1638 Ervin R.B., 2013, NCHS DATA BRIEF, V122, P1, DOI DOI 10.1089/152460902753668448 Fan JG, 2013, J GASTROEN HEPATOL, V28, P81, DOI 10.1111/jgh.12244 Gaskins AJ, 2010, AM J CLIN NUTR, V92, P1461, DOI 10.3945/ajcn.110.000026 Howards PP, 2009, AM J EPIDEMIOL, V169, P105, DOI 10.1093/aje/kwn287 Johnson RK, 2009, CIRCULATION, V120, P1011, DOI 10.1161/CIRCULATIONAHA.109.192627 Johnston RD, 2013, GASTROENTEROLOGY, V145, P1016, DOI 10.1053/j.gastro.2013.07.012 Lazo M, 2011, BMJ-BRIT MED J, V343, DOI 10.1136/bmj.d6891 Liangpunsakul S, 2005, AM J MED SCI, V329, P111, DOI 10.1097/00000441-200503000-00001 Lyssiotis CA, 2013, NATURE, V502, P181, DOI 10.1038/502181a Maersk M, 2012, AM J CLIN NUTR, V95, P283, DOI 10.3945/ajcn.111.022533 Miller PE, 2013, AM J PREV MED, V45, P416, DOI 10.1016/j.amepre.2013.05.014 Noguchi Hiroo, 1995, Acta Paediatrica Japonica, V37, P621 Nseir W, 2010, WORLD J GASTROENTERO, V16, P2579, DOI 10.3748/wjg.v16.i21.2579 Ouyang X, 2008, J HEPATOL, V48, P993, DOI 10.1016/j.jhep.2008.02.011 Park Youngmee K., 1993, American Journal of Clinical Nutrition, V58, p737S, DOI 10.1093/ajcn/58.5.737S Schaefer EJ, 2009, J NUTR, V139, pS1257, DOI 10.3945/jn.108.098186 Schakel Sally F., 1997, Journal of Food Composition and Analysis, V10, P102, DOI 10.1006/jfca.1997.0527 SCHAKEL SF, 1988, J AM DIET ASSOC, V88, P1268 Schakel SF, 2001, J FOOD COMPOS ANAL, V14, P315, DOI 10.1006/jfca.2001.0992 Schatzkin A, 2003, INT J EPIDEMIOL, V32, P1054, DOI 10.1093/ije/dyg264 Sobrecases H, 2010, DIABETES METAB, V36, P244, DOI 10.1016/j.diabet.2010.03.003 Subar AF, 2003, AM J EPIDEMIOL, V158, P1, DOI 10.1093/aje/kwg092 Vos MB, 2013, HEPATOLOGY, V57, P2525, DOI 10.1002/hep.26299 Wactawski-Wende J, 2009, PAEDIATR PERINAT EP, V23, P171, DOI 10.1111/j.1365-3016.2008.00985.x Welsh JA, 2011, AM J CLIN NUTR, V94, P726, DOI 10.3945/ajcn.111.018366 NR 31 TC 17 Z9 18 U1 1 U2 10 PU SPRINGER HEIDELBERG PI HEIDELBERG PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY SN 1436-6207 EI 1436-6215 J9 EUR J NUTR JI Eur. J. Nutr. PD MAR PY 2016 VL 55 IS 2 BP 569 EP 576 DI 10.1007/s00394-015-0876-3 PG 8 WC Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Nutrition & Dietetics GA DF3RD UT WOS:000371262400013 PM 25801628 OA Green Submitted DA 2026-02-02 ER PT J AU Trico, òD Masoni, MC Baldi, S Cimbalo, N Sacchetta, L Scozzaro, MT Nesti, G Mengozzi, A Nesti, L Chiriac, M Natali, A AF Trico, Domenico Masoni, Maria Chiara Baldi, Simona Cimbalo, Noemi Sacchetta, Luca Scozzaro, Maria Tiziana Nesti, Giulia Mengozzi, Alessandro Nesti, Lorenzo Chiriaco, Martina Natali, Andrea TI Early time-restricted carbohydrate consumption vs conventional dieting in type 2 diabetes: a randomised controlled trial SO DIABETOLOGIA LA English DT Article DE Blood glucose control; Circadian rhythm; Dietary carbohydrates; Glucagon; Glucose-dependent insulinotropic peptide; Nutrition therapy; Obesity; Randomised controlled trial; Time-restricted eating; Type 2 diabetes ID REDUCED MEAL FREQUENCY; ORAL GLUCOSE-TOLERANCE; CALORIC RESTRICTION; NORMAL-WEIGHT; HEALTHY; MEN AB Aims/hypothesis Early time-restricted carbohydrate consumption (eTRC) is a novel dietary strategy that involves restricting carbohydrate-rich food intake to the morning and early afternoon to align with circadian variations in glucose tolerance. We examined the efficacy, feasibility and safety of eTRC in individuals with type 2 diabetes under free-living conditions. Methods In this randomised, parallel-arm, open label, controlled trial, participants with type 2 diabetes and overweight/obesity (age 67.2 +/- 7.9 years, 47.8% women, BMI 29.4 +/- 3.7 kg/m(2), HbA(1c) 49 +/- 5 mmol/mol [6.6 +/- 0.5%]) were randomised, using computer-generated random numbers, to a 12 week eTRC diet or a Mediterranean-style control diet with matched energy restriction and macronutrient distribution (50% carbohydrate, 30% fat and 20% protein). The primary outcome was the between-group difference in HbA(1c) at 12 weeks. Body composition, 14 day flash glucose monitoring and food diary analysis were performed every 4 weeks. Mixed meal tolerance tests with mathematical beta cell function modelling were performed at baseline and after 12 weeks. Results Twelve (85.7%) participants in the eTRC arm and 11 (84.6%) participants in the control arm completed the study, achieving similar reductions in body weight and fat mass. The two groups experienced comparable improvements in HbA(1c) (-3 [-6, -0.3] mmol/mol vs -4 [-6, -2] mmol/mol, corresponding to -0.2 [-0.5, 0]% and -0.3 [-0.5, -0.1]%, respectively, p=0.386), fasting plasma glucose, flash glucose monitoring-derived glucose variability and mixed meal tolerance test-derived glucose tolerance, insulin resistance, insulin clearance and plasma glucagon levels, without changes in model-derived beta cell function parameters, glucagon-like peptide-1, glucose-dependent insulinotropic polypeptide and non-esterified fatty acid levels. The two diets similarly reduced liver function markers and triglyceride levels, being neutral on other cardiometabolic and safety variables. In exploratory analyses, diet-induced changes in body weight and glucometabolic variables were not related to the timing of carbohydrate intake. Conclusions/interpretation The proposed eTRC diet provides a feasible and effective alternative option for glucose and body weight management in individuals with type 2 diabetes, with no additional metabolic benefits compared with conventional dieting. C1 [Trico, Domenico; Masoni, Maria Chiara; Baldi, Simona; Cimbalo, Noemi; Sacchetta, Luca; Scozzaro, Maria Tiziana; Mengozzi, Alessandro; Nesti, Lorenzo; Chiriaco, Martina; Natali, Andrea] Univ Pisa, Dept Clin & Expt Med, Pisa, Italy. [Trico, Domenico; Masoni, Maria Chiara; Baldi, Simona; Cimbalo, Noemi; Sacchetta, Luca; Scozzaro, Maria Tiziana; Nesti, Giulia; Nesti, Lorenzo; Chiriaco, Martina; Natali, Andrea] Univ Pisa, Lab Metab Nutr & Atherosclerosis, Pisa, Italy. [Trico, Domenico; Natali, Andrea] Univ Pisa, Interdept Res Ctr Nutrafood Nutraceut & Food Hlth, Pisa, Italy. [Mengozzi, Alessandro; Chiriaco, Martina] Inst Life Sci, St Anna Sch Adv Studies, Pisa, Italy. [Mengozzi, Alessandro] Univ Zurich, Univ Hosp Zurich, Ctr Translat & Expt Cardiol CTEC, Dept Cardiol, Zurich, Switzerland. C3 University of Pisa; University of Pisa; University of Pisa; Scuola Superiore Sant'Anna; University of Zurich; University Zurich Hospital RP Trico, òD; Natali, A (通讯作者)，Univ Pisa, Dept Clin & Expt Med, Pisa, Italy.; Trico, òD; Natali, A (通讯作者)，Univ Pisa, Lab Metab Nutr & Atherosclerosis, Pisa, Italy.; Trico, òD; Natali, A (通讯作者)，Univ Pisa, Interdept Res Ctr Nutrafood Nutraceut & Food Hlth, Pisa, Italy. EM domenico.trico@unipi.it; andrea.natali@unipi.it RI Chiriacò, Martina/AAY-2611-2021; Sacchetta, Luca/KDO-7055-2024; Tricò, Domenico/A-9002-2017; Mengozzi, Alessano/JSK-7085-2023; Nesti, Lorenzo/AAB-7426-2022 OI Chiriacò, Martina/0000-0003-0174-4549; Sacchetta, Luca/0000-0001-7005-1215; Cimbalo, Noemi/0009-0004-6999-1823; Tricò, Domenico/0000-0002-7633-1346; Mengozzi, Alessano/0000-0003-2834-9725; SCOZZARO, MARIA TIZIANA/0000-0001-8327-2295; Nesti, Lorenzo/0000-0002-0560-6496 FU European Society for Clinical Nutrition and Metabolism (ESPEN Research Fellowship); Italian Society of Diabetology FX This study was supported by the European Society for Clinical Nutrition and Metabolism (ESPEN Research Fellowship to DT) and the Italian Society of Diabetology (Research Fellowships to DT and AN). CR Andriessen C, 2022, DIABETOLOGIA, V65, P1710, DOI 10.1007/s00125-022-05752-z [Anonymous], 2015, DIABETES CARE, V38, pS8, DOI [10.2337/dc17-s005, 10.2337/dc15-S005] Bedogni G, 2006, BMC GASTROENTEROL, V6, DOI 10.1186/1471-230X-6-33 Bizzotto R, 2021, DIABETES CARE, V44, P2115, DOI 10.2337/dc21-0545 Carlson O, 2007, METABOLISM, V56, P1729, DOI 10.1016/j.metabol.2007.07.018 Chang CR, 2019, AM J CLIN NUTR, V109, P1302, DOI 10.1093/ajcn/nqy261 Che TT, 2021, NUTR METAB, V18, DOI 10.1186/s12986-021-00613-9 D'Alessandro A, 2019, NUTRIENTS, V11, DOI 10.3390/nu11061296 Forouhi NG, 2023, DIABETOLOGIA, V66, P786, DOI 10.1007/s00125-023-05873-z Galderisi A, 2019, DIABETES, V68, P2074, DOI 10.2337/db19-0120 Hutchison AT, 2019, OBESITY, V27, P724, DOI 10.1002/oby.22449 Jakubowicz D, 2021, NUTRIENTS, V13, DOI 10.3390/nu13051558 Jakubowicz D, 2015, DIABETOLOGIA, V58, P912, DOI 10.1007/s00125-015-3524-9 Jamshed H, 2019, NUTRIENTS, V11, DOI 10.3390/nu11061234 JARRETT RJ, 1969, BRIT MED J, V2, P341, DOI 10.1136/bmj.2.5653.341 Kessler K, 2017, SCI REP-UK, V7, DOI 10.1038/srep44170 Lalama E., 2023, DIABETOL STOFFWECHS, V18, pS7, DOI [10.1055/s-0043-1767844, DOI 10.1055/S-0043-1767844] Liu DY, 2022, NEW ENGL J MED, V386, P1495, DOI 10.1056/NEJMoa2114833 Mari A, 2008, DIABETES OBES METAB, V10, P77, DOI 10.1111/j.1463-1326.2008.00946.x Matsuda M, 1999, DIABETES CARE, V22, P1462, DOI 10.2337/diacare.22.9.1462 Nesti L, 2019, FRONT ENDOCRINOL, V10, DOI 10.3389/fendo.2019.00144 Ong KL, 2023, LANCET, V402, P203, DOI 10.1016/S0140-6736(23)01301-6 Pearce KL, 2008, AM J CLIN NUTR, V87, P638, DOI 10.1093/ajcn/87.3.638 Reynolds A, 2023, DIABETOLOGIA, V66, P965, DOI 10.1007/s00125-023-05894-8 Schuppelius B, 2021, FRONT ENDOCRINOL, V12, DOI 10.3389/fendo.2021.683140 Stote KS, 2007, AM J CLIN NUTR, V85, P981, DOI 10.1093/ajcn/85.4.981 Sutton EF, 2018, CELL METAB, V27, P1212, DOI 10.1016/j.cmet.2018.04.010 Teong XT, 2023, NAT MED, V29, DOI 10.1038/s41591-023-02287-7 Trico D, 2022, METABOLISM, V134, DOI 10.1016/j.metabol.2022.155247 Tricò D, 2021, NUTRIENTS, V13, DOI 10.3390/nu13041345 Tricò D, 2020, DIABETES OBES METAB, V22, P1628, DOI 10.1111/dom.14076 Tricò D, 2018, HEPATOLOGY, V68, P1376, DOI 10.1002/hep.30035 Tricò D, 2015, DIABETOLOGIA, V58, P2503, DOI 10.1007/s00125-015-3710-9 VANCAUTER E, 1992, DIABETES, V41, P368, DOI 10.2337/diabetes.41.3.368 Varady KA, 2022, NAT REV ENDOCRINOL, V18, P309, DOI 10.1038/s41574-022-00638-x NR 35 TC 8 Z9 11 U1 2 U2 25 PU SPRINGER PI NEW YORK PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES SN 0012-186X EI 1432-0428 J9 DIABETOLOGIA JI Diabetologia PD FEB PY 2024 VL 67 IS 2 BP 263 EP 274 DI 10.1007/s00125-023-06045-9 EA NOV 2023 PG 12 WC Endocrinology & Metabolism WE Science Citation Index Expanded (SCI-EXPANDED) SC Endocrinology & Metabolism GA EV4M7 UT WOS:001102560000001 PM 37971503 OA Green Submitted, Green Accepted, hybrid DA 2026-02-02 ER PT J AU Colpo, E Vilanova, CDDA Reetz, LGB Duarte, MMMF Farias, ILG Meinerz, DE Mariano, DOC Vendrusculo, RG Boligon, AA Corte, CLD Wagner, R Athayde, ML Da Rocha, JBT AF Colpo, Elisangela Vilanova, Carlos Dalton D. A. Reetz, Luiz Gustavo B. Duarte, Marta M. M. F. Farias, Iria Luiza G. Meinerz, Daiane E. Mariano, Douglas O. C. Vendrusculo, Raquel G. Boligon, Aline A. Corte, Cristiane L. Dalla Wagner, Roger Athayde, Margareth L. da Rocha, Joao Batista T. TI Brazilian nut consumption by healthy volunteers improves inflammatory parameters SO NUTRITION LA English DT Article DE Human; Interleukin; Unsaturated fatty acids; Selenium; C-reactive protein; Nutrition; Oxidative stress ID CARDIOVASCULAR RISK-FACTORS; MEDITERRANEAN-STYLE DIET; IMMUNE CELL FUNCTIONS; ENDOTHELIAL FUNCTION; METABOLIC SYNDROME; RANDOMIZED-TRIAL; FATTY-ACIDS; OLIVE OIL; SELENIUM; SUPPLEMENTATION AB Objective: The aim of this study was to investigate the effect of a single dose of Brazil nuts on the inflammatory markers of healthy individuals. Method: A randomized crossover study was conducted with 10 healthy individuals (mean age 24.7 +/- 3.4 y). Each individual was tested four times regarding intake of different portions of Brazil nuts: 0, 5,20 and 50g. At each testing period, peripheral blood was collected before and at 1, 3, 6, 9, 24, and 48 h after intake of nuts, as well as at 5 and 30 d after intake of various Brazil nut portions. Blood samples were tested for high-sensitivity to C-reactive protein, interleukin (IL)-1, IL-6, IL-10, tumor necrosis factor (TNF)-alpha, and interferon (IFN)-gamma, aspartate and alanine aminotransferases, albumin, total protein, alkaline phosphatase, gamma-glutamyltransferase, urea, and creatinine. Results: Consumption of nuts did not affect biochemical parameters for liver and kidney function, indicating absence of hepatic and renal toxicity. A single intake of Brazil nuts (20 or 50 g) caused a significant decrease in serum IL-1, IL-6, TNF-alpha, and IFN-gamma levels (P < 0.05), whereas serum levels of IL-10 were significantly increased (P < 0.05). Conclusion: The results indicate a long-term decrease in inflammatory markers after a single intake of large portions of Brazil nuts in healthy volunteers. Therefore, the long-term effect of regular Brazil nut consumption on inflammatory markers should be better investigated. (C) 2014 Elsevier Inc. All rights reserved. C1 [Colpo, Elisangela; Vilanova, Carlos Dalton D. A.; Duarte, Marta M. M. F.; Meinerz, Daiane E.; Mariano, Douglas O. C.; Corte, Cristiane L. Dalla; da Rocha, Joao Batista T.] Univ Fed Santa Maria, Nat & Exact Sci Ctr, Dept Biochem & Mol Biol, BR-97119900 Santa Maria, RS, Brazil. [Reetz, Luiz Gustavo B.; Farias, Iria Luiza G.] Univ Fed Santa Maria, Univ Hosp, Clin Lab Anal, BR-97119900 Santa Maria, RS, Brazil. [Colpo, Elisangela] Ctr Franciscan Univ, Dept Nutr, Santa Maria, RS, Brazil. [Duarte, Marta M. M. F.] Univ Luterana Brasil, Santa Maria, RS, Brazil. [Vendrusculo, Raquel G.; Wagner, Roger] Univ Fed Santa Maria, Dept Technol & Food & Sci, BR-97119900 Santa Maria, RS, Brazil. [Boligon, Aline A.; Athayde, Margareth L.] Univ Fed Santa Maria, Dept Ind Pharm, BR-97119900 Santa Maria, RS, Brazil. C3 Universidade Federal de Santa Maria (UFSM); Universidade Federal de Santa Maria (UFSM); Universidade Luterana do Brasil; Universidade Federal de Santa Maria (UFSM); Universidade Federal de Santa Maria (UFSM) RP Da Rocha, JBT (通讯作者)，Univ Fed Santa Maria, Nat & Exact Sci Ctr, Dept Biochem & Mol Biol, BR-97119900 Santa Maria, RS, Brazil. EM Jbtrocha@pq.cnpq.br RI Lenz Dalla Corte, Cristiane/J-3050-2012; Mariano, Douglas/F-4277-2014; Wagner, Roger/I-1538-2014; Rocha, Joao Batista Teixeira da/S-6813-2016; Colpo, Elisângela/Q-1683-2016; Guidetti Venuscolo, Raquel/ABG-1961-2021 OI Lenz Dalla Corte, Cristiane/0000-0003-3478-626X; Mariano, Douglas/0000-0001-7296-5475; Wagner, Roger/0000-0002-6176-7913; Rocha, Joao Batista Teixeira da/0000-0003-3829-0595; Colpo, Elisângela/0000-0002-3886-0765; de Avila Vilanova, Carlos Dalton/0000-0002-5363-7000; Guidetti Venuscolo, Raquel/0000-0002-3867-7602 FU National Counsel of Technological and Scientific Development (CNPq) FX This work was financed by grants received from the National Counsel of Technological and Scientific Development (CNPq). 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First, extensive BLAST searches were done on the gilthead sea bream cDNA database of the AQUAMAX European Project (www.sigenae.org/iats), and six contigs were unequivocally identified as PRDX1-6 after sequence completion by RT-PCR. The phylogenetic analysis evidenced three major clades corresponding to PRDX1-4 (true 2-Cyst PRDX subclass), PRDX5 (atypical 2-Cys PRDX subclass) and PRDX6 (1-Cys PRDX subclass) that reflected the present hierarchy of vertebrates. However, the PRDX2 branch of modern fish including gilthead sea bream was related to the monophyletic PRDX1 node rather than to PRDX2 cluster of mammals and primitive fish, which probably denotes the acquisition of novel functions through vertebrate evolution. Transcriptional studies by means of quantitative real-time PCR evidenced a ubiquitous PRDX gene expression that was tissue specific for each PRDX isoform. In a second set of transcriptional studies, liver and head kidney were chosen as target tissues in fish challenged with i) the intestinal parasite Enteromyxum leei, ii) a plant oil (VO) diet with deficiencies in essential fatty acids and iii) prolonged exposure to high-rearing densities. These studies showed that PRDX genes were highly and mostly constitutively expressed in the liver and were not affected by dietary intervention or high density. In contrast, head kidney was highly sensitive to the different experimental challenges: significantly lower values were found for PRDX5 in the three trials, for PRDX6 in parasitized and high density fish and for PRDX1 in parasitized and VO fish. PRDX2, 3 and 5 were decreased only in VO, high density and parasitized animals, respectively. These findings would highlight the role of PRDXs as integrative and highly predictive biomarkers of health and welfare in fish and gilthead sea bream in particular. (C) 2011 Elsevier Ltd. All rights reserved. C1 [Perez-Sanchez, Jaume; Bermejo-Nogales, Azucena; Alvar Calduch-Giner, Josep] CSIC, Inst Aquaculture Torre de la Sal, Fish Nutr & Growth Endocrinol Grp, Dept Marine Species Biol Culture & Pathol, Castellon de La Plana, Spain. [Kaushik, Sadasivam] INRA, UR 1067, F-64310 St Pee Sur Nivelle, France. [Sitja-Bobadilla, Ariadna] CSIC, Inst Aquaculture Torre de la Sal, Fish Pathol Grp, Dept Marine Species Biol Culture & Pathol, Castellon de La Plana, Spain. C3 Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Instituto de Acuicultura de Torre de la Sal (IATS); INRAE; Universite de Pau et des Pays de l'Adour; Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Instituto de Acuicultura de Torre de la Sal (IATS) RP Pérez-Sánchez, J (通讯作者)，CSIC, Inst Aquaculture Torre de la Sal, Fish Nutr & Growth Endocrinol Grp, Dept Marine Species Biol Culture & Pathol, Castellon de La Plana, Spain. EM jperez@iats.csic.es RI Sitjà-Bobadilla, Ariadna/J-2715-2014; Pérez Sánchez, Jaume/K-3231-2014; Calduch-Giner, Josep/K-8253-2014; Bermejo-Nogales, Azucena/K-7855-2014; Kaushik, Sadasivam/HTO-8623-2023 OI Sitjà-Bobadilla, Ariadna/0000-0002-7473-3413; Pérez Sánchez, Jaume/0000-0003-2506-1523; Calduch-Giner, Josep/0000-0003-3124-5986; Bermejo-Nogales, Azucena/0000-0002-7163-7338; Kaushik, Sadasivam/0000-0001-7856-8374 FU AQUAGENOMICS [CSD2007-00002]; AQUAFAT [AGL2009-07797]; ENTEROMYX CONTROL [AGL2009-13282-C02-01]; Generalitat Valenciana [PROMETEO 2010/006] FX The research was funded by AQUAGENOMICS (project no. CSD2007-00002, Improvement of aquaculture production by the use of biotechnological tools), AQUAFAT (AGL2009-07797; Predictive modeling of flesh fatty acid composition in cultured fish species with different muscle lipid content), and ENTEROMYX CONTROL (AGL2009-13282-C02-01) projects. Additional funding was obtained from the "Generalitat Valenciana" (research grant PROMETEO 2010/006). The authors are grateful to M.A. Gonzalez for the excellent technical assistance in PCR analysis. 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PD AUG PY 2011 VL 31 IS 2 BP 294 EP 302 DI 10.1016/j.fsi.2011.05.015 PG 9 WC Fisheries; Immunology; Marine & Freshwater Biology; Veterinary Sciences WE Science Citation Index Expanded (SCI-EXPANDED) SC Fisheries; Immunology; Marine & Freshwater Biology; Veterinary Sciences GA 798KL UT WOS:000293204500016 PM 21640832 OA Green Submitted DA 2026-02-02 ER PT J AU Yang, G Wei, JL Liu, PY Zhang, QH Tian, Y Hou, GW Meng, LB Xin, Y Jiang, X AF Yang, Ge Wei, Jinlong Liu, Pinyi Zhang, Qihe Tian, Yuan Hou, Guowen Meng, Lingbin Xin, Ying Jiang, Xin TI Role of the gut microbiota in type 2 diabetes and related diseases SO METABOLISM-CLINICAL AND EXPERIMENTAL LA English DT Article DE Gut microbiota; Type 2 diabetes; Nonalcoholic fatty liver disease; Diabetic cardiovascular disease; Diabetic nephropathy; Diabetic retinopathy; Intestinal barrier; Gut microbiota metabolites; Microbiological therapy ID FATTY LIVER-DISEASE; LACTOBACILLUS-RHAMNOSUS GG; INNATE LYMPHOID-CELLS; DIET-INDUCED OBESITY; CHAIN AMINO-ACIDS; INTESTINAL MICROBIOTA; MEDITERRANEAN DIET; CARDIOVASCULAR-DISEASE; LACTOCOCCUS-LACTIS; METABOLIC SYNDROME AB Type 2 diabetes is the fastest-growing metabolic disease in the world. Many clinical studies have found that type 2 diabetes patients have metabolic disorders and chronic inflammatory states accompanied by disturbances in the gut microbiota. The gut microbiota plays an important role in body metabolism and immune regulation, and disturbances in the gut microbiota in conjunction with destruction of the intestinal barrier in type 2 diabetes patients causes damage to multiple organs. Therefore, the gut microbiota may be a new therapeutic target for treating type 2 diabetes and related diseases. In this review, we introduce the characteristics of the gut microbiota in type 2 diabetes and related diseases, as well as highlight the potential molecular mechanisms of their effects on intestinal barrier disruption, metabolic disorders, and chronic inflammation. Finally, we summarize an intestinal microecological therapeutic strategy, with a focus on shaping the intestinal bacteria, to improve the malignant progress of type 2 diabetes and related diseases. Author summary: Type 2 diabetes (T2D) is the fastest-growing metabolic disease in the world. Many clinical studies have found that T2D patients have metabolic disorders and chronic inflammatory states, accompanied by disturbances of the gut microbiota and increased intestinal permeability. The number of human gut microbiota is more than 10 times of human cells, and they play an important role in the body's metabolism and immune regulation. The abnormal intestinal metabolites and intestinal barrier disruption caused by the gut microbiota dysbiosis in the T2D facilitate intestinal bacteria and their harmful metabolites entering the circulatory system. The abnormal entering will cause the damage to multiple organs through disturbing insulin sensitivity, glucose metabolism, and immune homeostasis. Therefore, the gut microbiota may be a new therapeutic target for improving T2D and its related diseases. In this review, we introduce the compositional characteristics of the gut microbiota in T2D, and highlight some new molecular mechanisms of their effects on intestinal barrier disruption, metabolic disorders and chronic inflammation in T2D and its related diseases. Finally, we summarize an intestinal microecological therapeutic strategy, with a focus on shaping the intestinal bacteria, to improve the malignant progress of T2D and related diseases. ? 2021 Elsevier Inc. All rights reserved. C1 [Yang, Ge; Wei, Jinlong; Liu, Pinyi; Zhang, Qihe; Hou, Guowen; Jiang, Xin] First Hosp Jilin Univ, Dept Radiat Oncol, 71 Xinmin St, Changchun 130021, Peoples R China. [Yang, Ge; Liu, Pinyi; Zhang, Qihe; Tian, Yuan; Hou, Guowen; Xin, Ying] Jilin Univ, Key Lab Pathobiol, Minist Educ, 126 Xinmin St, Changchun 130021, Peoples R China. [Yang, Ge; Wei, Jinlong; Liu, Pinyi; Zhang, Qihe; Hou, Guowen; Jiang, Xin] First Hosp Jilin Univ, Jilin Prov Key Lab Radiat Oncol & Therapy, Changchun 130021, Peoples R China. [Tian, Yuan] Second Hosp Jilin Univ, Dept Gynecol, Changchun 130041, Peoples R China. [Meng, Lingbin] H Lee Moffitt Canc Ctr & Res Inst, Dept Hematol & Med Oncol, Tampa, FL 33612 USA. C3 Jilin University; Jilin University; Jilin University; Jilin University; H Lee Moffitt Cancer Center & Research Institute RP Jiang, X (通讯作者)，First Hosp Jilin Univ, Dept Radiat Oncol, 71 Xinmin St, Changchun 130021, Peoples R China.; Xin, Y (通讯作者)，Jilin Univ, Key Lab Pathobiol, Minist Educ, 126 Xinmin St, Changchun 130021, Peoples R China. EM xiny@jlu.edu.cn; jiangx@jlu.edu.cn RI ; Jiang, Xin/AHA-9454-2022 OI Xin, Ying/0000-0001-7591-9423; Jiang, Xin/0000-0002-4613-7438 FU National Natural Science Foundation of China [81570344]; National Key Research and Development Program of China [2017YFC0112100]; Health and Family Planning Commission of Jilin Province Foundations [2016Q034, 2017J11]; Jilin Provincial Science and Technology Foundations [20180414039GH, 20190201200JC] FX This work was supported by [the National Natural Science Foundation of China] under Grant [number 81570344] to Ying Xin; [National Key Research and Development Program of China] under Grant [number 2017YFC0112100] to Xin Jiang; [the Health and Family Planning Commission of Jilin Province Foundations] under Grant [number 2016Q034 and 2017J11] and [the Jilin Provincial Science and Technology Foundations] under Grant [number 20180414039GH and 20190201200JC] to Xin Jiang. Ying Xin and Xin Jiang both played any role in study design and decision to publish. 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Exp. PD APR PY 2021 VL 117 AR 154712 DI 10.1016/j.metabol.2021.154712 EA FEB 2021 PG 13 WC Endocrinology & Metabolism WE Science Citation Index Expanded (SCI-EXPANDED) SC Endocrinology & Metabolism GA RC3FB UT WOS:000632688100007 PM 33497712 HC Y HP N DA 2026-02-02 ER PT J AU Aidoud, A Ammouche, A Garrido, M Rodriguez, AB AF Aidoud, Aziouz Ammouche, Ali Garrido, Maria Rodriguez, Ana B. TI Effect of lycopene-enriched olive and argan oils upon lipid serum parameters in Wistar rats SO JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE LA English DT Article DE lycopene; virgin olive oil; argan oil; low-density lipoprotein-cholesterol; high-density lipoprotein-cholesterol; triglyceride ID FATTY-ACID-COMPOSITION; PHENOLIC-COMPOUNDS; TOMATO PRODUCTS; LDL OXIDATION; ANTIOXIDANT ACTIVITY; MEDITERRANEAN DIET; RISK-FACTORS; SPINOSA L.; CHOLESTEROL; LIVER AB BACKGROUND: Lycopene has the highest antioxidant activity within carotenoids and is an effective free radical scavenger. Virgin olive oil (VOO) and argan oil (AO) contain trace amounts of a wide variety of phytochemicals which have desirable nutritional properties. The present study intended to assess the effect of various dietary VOO and AO in combination with lycopene consumption on serum biochemical parameters, including total cholesterol (TC), low-density lipoprotein-cholesterol (LDL-C), high-density lipoprotein-cholesterol (HDL-C), triglycerides (TGs) and phospholipids, as well as on hepatosomatic index (HSI) of rats. RESULTS: Results showed that ingestion of VOO and AO diminished TC, LDL-C, TGs and phospholipid levels, whereas the HDL-C levels augmented in all the groups assayed. The enrichment of VOO and AO with lycopene improved the beneficial effects derived from the consumption of both oils on serum biochemical parameters. A decrease in body weight gain and HSI was detected after the consumption of lycopene-enriched oils. CONCLUSION: These findings suggest that the inclusion of lycopene in VOO and AO may be used as a natural tool to fight against hyperlipidaemic and hypercholesterolaemic-derived disorders. (C) 2014 Society of Chemical Industry C1 [Aidoud, Aziouz] Ziane Achour Univ, Fac Life & Nat Sci, Dept Biol, Djelfa, Algeria. [Ammouche, Ali] Natl High Coll Agron El Harrach, Dept Food Technol & Human Nutr, Algiers 16111, Algeria. [Garrido, Maria; Rodriguez, Ana B.] Univ Extremadura, Fac Sci, Dept Physiol, Neuroimmunophysiol & Chrononutr Res Grp, Badajoz 06006, Spain. C3 Universite de Djelfa; Universidad de Extremadura RP Garrido, M (通讯作者)，Univ Extremadura, Fac Sci, Dept Physiol, Avda Elvas S-N, Badajoz 06006, Spain. 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Sci. Food Agric. PD NOV PY 2014 VL 94 IS 14 BP 2943 EP 2950 DI 10.1002/jsfa.6638 PG 8 WC Agriculture, Multidisciplinary; Chemistry, Applied; Food Science & Technology WE Science Citation Index Expanded (SCI-EXPANDED) SC Agriculture; Chemistry; Food Science & Technology GA AQ5ET UT WOS:000342829800015 PM 24615399 DA 2026-02-02 ER PT J AU Ramos-Lopez, O Martinez, JA Milagro, F AF Ramos-Lopez, Omar Alfredo Martinez, J. Milagro, Fermin, I TI Holistic Integration of Omics Tools for Precision Nutrition in Health and Disease SO NUTRIENTS LA English DT Review DE precision nutrition; holistic approach; genomics; epigenomics; metagenomics; transcriptomics; proteomics; metabolomics ID DNA METHYLATION; GENETIC-VARIANTS; MEDITERRANEAN DIET; TELOMERE LENGTH; GUT MICROBIOTA; VITAMIN-D; METABOLISM; POLYMORPHISM; REVEAL; METABOLOMICS AB The combination of multiple omics approaches has emerged as an innovative holistic scope to provide a more comprehensive view of the molecular and physiological events underlying human diseases (including obesity, dyslipidemias, fatty liver, insulin resistance, and inflammation), as well as for elucidating unique and specific metabolic phenotypes. These omics technologies include genomics (polymorphisms and other structural genetic variants), epigenomics (DNA methylation, histone modifications, long non-coding RNA, telomere length), metagenomics (gut microbiota composition, enterotypes), transcriptomics (RNA expression patterns), proteomics (protein quantities), and metabolomics (metabolite profiles), as well as interactions with dietary/nutritional factors. Although more evidence is still necessary, it is expected that the incorporation of integrative omics could be useful not only for risk prediction and early diagnosis but also for guiding tailored dietary treatments and prognosis schemes. Some challenges include ethical and regulatory issues, the lack of robust and reproducible results due to methodological aspects, the high cost of omics methodologies, and high-dimensional data analyses and interpretation. In this review, we provide examples of system biology studies using multi-omics methodologies to unravel novel insights into the mechanisms and pathways connecting the genotype to clinically relevant traits and therapy outcomes for precision nutrition applications in health and disease. C1 [Ramos-Lopez, Omar] Autonomous Univ Baja California, Med & Psychol Sch, Tijuana 22390, Mexico. [Alfredo Martinez, J.] CEI UAM CSIC, IMDEA Food Inst, Precis Nutr & Cardiometab Hlth, Madrid 28049, Spain. [Milagro, Fermin, I] Univ Navarra, Dept Nutr Food Sci & Physiol, Pamplona 31008, Spain. [Milagro, Fermin, I] Univ Navarra, Ctr Nutr Res, Pamplona 31008, Spain. [Milagro, Fermin, I] Inst Hlth Carlos III, Ctr Invest Biomed Red Fisiopatol Obesidad & Nutr, Madrid 28029, Spain. [Milagro, Fermin, I] Navarra Inst Hlth Res IdiSNA, Pamplona 31008, Spain. C3 Universidad Autonoma de Baja California; Consejo Superior de Investigaciones Cientificas (CSIC); IMDEA Food Institute; University of Navarra; University of Navarra; CIBER - Centro de Investigacion Biomedica en Red; CIBEROBN; University of Navarra RP Ramos-Lopez, O (通讯作者)，Autonomous Univ Baja California, Med & Psychol Sch, Tijuana 22390, Mexico. EM oscar.omar.ramos.lopez@uabc.edu.mx RI Milagro, Fermin I/F-2315-2015; Ramos Lopez, Omar/ABH-6978-2020; Martínez, J./K-8709-2014 OI Milagro, Fermin I/0000-0002-3228-9916; Ramos Lopez, Omar/0000-0002-2505-1555; FU CIBER [CB12/03/30002]; Gobierno de Navarra [PT024, PI035, 0011-1411-2018-000040]; PRODEP-Mexico program [UABC-PTC-796]; Synergic R&D Projects in New and Emerging Scientific Areas on the Frontier of Science and Interdisciplinary Nature of The Community of Madrid [METAINFLAMATION-Y2020/BIO-6600] FX This research was funded by CIBER (CB12/03/30002) and Gobierno de Navarra: Obekit (PT024), Microbiota (PI035), and Nutribiota (0011-1411-2018-000040) projects. The PRODEP-Mexico program (UABC-PTC-796) is also gratefully acknowledged. Support from Synergic R&D Projects in New and Emerging Scientific Areas on the Frontier of Science and Interdisciplinary Nature of The Community of Madrid (METAINFLAMATION-Y2020/BIO-6600) is also credited. 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Dietetics GA 5G4SE UT WOS:000866989400001 PM 36235725 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Serrano, R Blanes, MA López, FJ AF Serrano, Roque Blanes, Miguel A. Lopez, Francisco J. TI Biomagnification of organochlorine pollutants in farmed and wild gilthead sea bream (Sparus aurata) and stable isotope characterization of the trophic chains SO SCIENCE OF THE TOTAL ENVIRONMENT LA English DT Article DE organochlorine compounds; gilthead sea bream; Sparus aurata; farmed fish; wild fish; stable isotopes ID GAS-CHROMATOGRAPHY; ATLANTIC SALMON; ORGANOPHOSPHORUS COMPOUNDS; MULTIRESIDUE DETERMINATION; HEAVY-METALS; FOOD WEBS; FISH; CONTAMINANTS; PESTICIDES; AQUACULTURE AB Organochlorine pollutants (pesticides and polychlorinated biphenyls) were analysed in farmed and wild gilthead sea bream (Sparus aurata) tissues (white muscle and liver) from the Western Mediterranean (Spain) and in their diets. Determination was carried out by gas chromatography coupled to tandem mass spectrometry after clean up of the fatty extracts by normal phase HPLC, with detection limits around 0.1 ng/g. Carbon and nitrogen stable isotope ratios were also determined in the samples. Organochlorine compounds concentration was found to be uniform throughout the year in farmed fish, in both white muscle and liver. In contrast, wild fish showed contamination profiles that reflect environmental factors and the biological cycle. Although biomagnification factors for white muscle and liver were found to be 2.4 and 3.0, respectively for farmed fish, and 0.15 and 0.54 for wild specimens, wild fish presented higher levels of organochlorine contaminants than farmed fish. Nitrogen stable isotopes determination in muscle from wild and fanned sea bream during the year gave us a profile related to the biological cycle. delta N-15 mean values from farmed fish were 2.0 parts per thousand higher than from wild fish throughout the year that corresponding to close to one trophic step. delta C-13 values were stable during the year, and also more enriched in the case of farmed fish. The low levels of contaminants found in the feed supplied to farmed fish explain the organochlorine concentrations in their tissues which remain below wild fish, in spite of the intensive culture conditions and higher trophic level of cultured specimens. (c) 2007 Elsevier B.V. All rights reserved. C1 [Serrano, Roque; Blanes, Miguel A.; Lopez, Francisco J.] Res Inst Pesticides & Water, Castellon de La Plana 12071, Spain. RP Serrano, R (通讯作者)，Res Inst Pesticides & Water, Avda Sos Baynat,s-n Univ Jaume 1, Castellon de La Plana 12071, Spain. 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Total Environ. PD JAN 25 PY 2008 VL 389 IS 2-3 BP 340 EP 349 DI 10.1016/j.scitotenv.2007.09.020 PG 10 WC Environmental Sciences WE Science Citation Index Expanded (SCI-EXPANDED) SC Environmental Sciences & Ecology GA 243WB UT WOS:000251826900016 PM 17945331 DA 2026-02-02 ER PT J AU Priore, P Caruso, D Siculella, L Gnoni, GV AF Priore, Paola Caruso, Donatella Siculella, Luisa Gnoni, Gabriele V. TI Rapid down-regulation of hepatic lipid metabolism by phenolic fraction from extra virgin olive oil SO EUROPEAN JOURNAL OF NUTRITION LA English DT Article DE Cholesterogenesis; Extra virgin olive oil; Lipogenesis; Phenol extract; Rat hepatocytes; Refined olive oil ID NUCLEAR-MAGNETIC-RESONANCE; CULTURED RAT-HEPATOCYTES; HEART-DISEASE MORTALITY; INHIBITS FATTY-ACID; MEDITERRANEAN DIET; RISK-FACTORS; TRIACYLGLYCEROL SYNTHESIS; MYOCARDIAL-INFARCTION; BIOLOGICAL-ACTIVITIES; PLATELET-AGGREGATION AB Purpose Regular consumption of extra virgin olive oil (EVOO) is associated with a low incidence of atherosclerotic diseases. The phenolic component contributes to the hypolipidemic action of EVOO, although the biochemical mechanisms leading this beneficial outcome are not fully understood. Since liver plays a pivotal role in the whole body lipid homeostasis, we investigated the short-term effects of EVOO extract, with a high phenol content (HPE), on lipid synthesis in primary rat hepatocytes. Refined olive oil extract, with a low phenol content, was used throughout this study as a control. Methods Olive oil phenols isolated with methanolic extractions were subsequently analyzed by high performance liquid chromatography, electrospray ionization tandem mass spectrometry, and gas chromatography mass spectrometry. Rat hepatocytes were obtained from collagenase perfusion of liver. A colorimetric assay was performed to exclude cytotoxicity of the extracts. Radiocnzymatic methods were used in order to investigate hepatic lipid metabolism. Results HPE, dose- (0.1- 50 mu g/mL) and time-dependently (0.5-4 h) inhibited both lipogenesis and cholesterogenesis (n = 6, P < 0.05), as well as triglycerides synthesis ( n = 5, P < 0.05). We showed that these effects are attributable to a short-term modulation by HPE of the key enzymes implicated in the abovementioned pathways ( n = 5, P < 0.05). Conclusions The decrease in hepatic lipid synthesis may represent a potential mechanism underlying the hypolipidemic effect of EVOO phenols. C1 [Priore, Paola; Siculella, Luisa; Gnoni, Gabriele V.] Univ Salento, Dept Biol & Environm Sci & Technol, Lab Biochem & Mol Biol, I-73100 Lecce, Italy. [Caruso, Donatella] Univ Milan, Res Ctr Characterizat & Safe Use Nat Cpds Giovann, Dept Pharmacol & Biomol Sci, Milan, Italy. C3 University of Salento; University of Milan RP Siculella, L (通讯作者)，Univ Salento, Dept Biol & Environm Sci & Technol, Lab Biochem & Mol Biol, Via Provle Lecce Monteroni, I-73100 Lecce, Italy. EM luisa.siculella@unisalento.it OI Siculella, Luisa/0000-0002-6890-3674 FU Apulia Region (Italy) [PON 01_01958 PIVOLIO] FX This work was supported by Grants from Apulia Region (Italy), PON 01_01958 PIVOLIO. 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J. Nutr. PD AUG PY 2015 VL 54 IS 5 BP 823 EP 833 DI 10.1007/s00394-014-0761-5 PG 11 WC Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Nutrition & Dietetics GA CN1PG UT WOS:000358191500015 PM 25296884 DA 2026-02-02 ER PT J AU Stevens, Y Winkens, B Jonkers, D Masclee, A AF Stevens, Yala Winkens, Bjorn Jonkers, Daisy Masclee, Adrian TI The effect of olive leaf extract on cardiovascular health markers: a randomized placebo-controlled clinical trial SO EUROPEAN JOURNAL OF NUTRITION LA English DT Article DE Olive leaf extract; Overweight; Cardiovascular disease; Blood lipid profiles ID OLEA-EUROPAEA L.; LIPOPROTEIN-CHOLESTEROL RATIO; MEDITERRANEAN DIET; FATTY-ACIDS; METAANALYSIS; OLEUROPEIN; DISEASE; OBESITY; CONSUMPTION; METABOLISM AB Purpose Overweight and obesity are associated with many health problems, including cardiovascular disease (CVD). Evidence from previous studies has shown that extracts from olive leaves rich in olive phenolics are able to positively affect CVD risk factors, such as high blood pressure and dyslipidemia. The aim of this study was to investigate the effect of 8-week olive leaf extract (OLE) administration on blood lipid profiles in overweight/obese subjects with mildly elevated cholesterol levels. Methods In this randomized, double-blind, placebo-controlled study, 77 healthy adult overweight/obese subjects (aged 56 +/- 10 years and BMI 29.0 +/- 2.7 kg/m(2)) with total cholesterol levels of 5.0-8.0 mmol/L (5.9 +/- 0.7 mmol/L) were randomly assigned to receive 500 mg of OLE (n = 39) or placebo (n = 38) for 8 weeks. In total, 74 subjects completed the entire study protocol. At baseline, after 4 weeks, and after 8 weeks of supplementation, blood lipid profiles, oxidized low-density lipoprotein (oxLDL), blood pressure, glucose, and insulin levels were assessed. In addition, liver function parameters were measured at baseline and after 8 weeks. Results OLE supplementation did not significantly affect blood lipid levels after 4 weeks or after 8 weeks compared to placebo (allp > 0.05). For oxLDL, blood pressure, glucose, and insulin levels and liver function parameters, also no statistically significant differences were found between the two intervention groups (allp > 0.05). Conclusions Blood lipid profiles were not significantly affected by 8 weeks OLE supplementation in overweight/obese subjects with mildly elevated cholesterol levels. Trial registered The trial has been registered at ClinicalTrials.gov (NCT02990637). C1 [Stevens, Yala; Jonkers, Daisy; Masclee, Adrian] Maastricht Univ, Sch Nutr & Translat Res Metab NUTRIM, Dept Internal Med, Div Gastroenterol Hepatol, POB 616, NL-6200 Maastricht, Netherlands. [Stevens, Yala] BioActor BV, Maastricht, Netherlands. [Winkens, Bjorn] Maastricht Univ, Care & Publ Hlth Res Inst CAPHRI, Dept Methodol & Stat, Maastricht, Netherlands. C3 Maastricht University; Maastricht University RP Stevens, Y (通讯作者)，Maastricht Univ, Sch Nutr & Translat Res Metab NUTRIM, Dept Internal Med, Div Gastroenterol Hepatol, POB 616, NL-6200 Maastricht, Netherlands.; Stevens, Y (通讯作者)，BioActor BV, Maastricht, Netherlands. EM yala.stevens@maastrichtuniversity.nl RI Winkens, Bjorn/ABK-8803-2022 OI Winkens, Bjorn/0000-0002-6747-6228; Stevens, Yala/0000-0003-4671-7739 FU BioActor BV, Maastricht, The Netherlands FX This work was in part funded by BioActor BV, Maastricht, The Netherlands. The funding source had no role in the design of the study, the analysis and interpretation of data, writing of the manuscript, or in the decision to submit the manuscript for publication. 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J. Nutr. PD JUN PY 2021 VL 60 IS 4 BP 2111 EP 2120 DI 10.1007/s00394-020-02397-9 EA OCT 2020 PG 10 WC Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Nutrition & Dietetics GA SF0TU UT WOS:000578553000001 PM 33034707 OA Green Published, Green Submitted, hybrid DA 2026-02-02 ER PT J AU Patti, AM Carruba, G Cicero, AFG Banach, M Nikolic, D Giglio, R Terranova, A Soresi, M Giannitrapani, L Montalto, G Stoian, AP Banerjee, Y Rizvi, AA Toth, PP Rizzo, M AF Patti, Angelo M. Carruba, Giuseppe Cicero, Arrigo F. G. Banach, Maciej Nikolic, Dragana Giglio, Rosaria, V Terranova, Antonino Soresi, Maurizio Giannitrapani, Lydia Montalto, Giuseppe Stoian, Anca Pantea Banerjee, Yajnavalka Rizvi, Ali A. Toth, Peter P. Rizzo, Manfredi TI Daily Use of Extra Virgin Olive Oil with High Oleocanthal Concentration Reduced Body Weight, Waist Circumference, Alanine Transaminase, Inflammatory Cytokines and Hepatic Steatosis in Subjects with the Metabolic Syndrome: A 2-Month Intervention Study SO METABOLITES LA English DT Article DE metabolic syndrome; olive oil; oleocanthal; polyphenols; cytokines ID MEDITERRANEAN DIET; LOW-DENSITY; CARDIOVASCULAR-DISEASE; PRIMARY PREVENTION; HEART-DISEASE; LIVER; NUTRACEUTICALS; LIPOPROTEINS; FAT; MARKERS AB Extra virgin olive oil (EVOO) intake is associated with reduced cardiovascular risk, and its phenolic compound oleocanthal (OC) has anti-oxidant and anti-inflammatory properties. The cardiometabolic effects of EVOO with a high OC concentration have not been fully elucidated. We administered EVOO with a high OC concentration daily to 23 subjects with the metabolic syndrome (MetS) and hepatic steatosis (15 men and 8 women, age: 60 +/- 11 years) for 2 months. Anthropometric data, metabolic parameters, hepatic steatosis (by fatty liver index, FLI), abdominal fat distribution (by ultrasound), and pro- and anti-inflammatory cytokines were assessed before and after the intervention. EVOO supplementation was associated with a reduction in body weight, waist circumference, body mass index (BMI), alanine transaminase and FLI, as well as interleukin (IL)-6, IL-17A, tumor necrosis factor-alpha and IL-1B, while IL-10 increased. Maximum subcutaneous fat thickness (SFT max) also increased, with a concomitant decrease in the ratio of visceral fat layer thickness/SFT max. Correlation analysis revealed positive associations between changes in body weight and BMI and those in SFT max, along with an inverse association between changes in IL-6 and those in SFT max. In conclusion, ingestion of EVOO with a high OC concentration had beneficial effects on metabolic parameters, inflammatory cytokines and abdominal fat distribution in MetS subjects with hepatic steatosis, a category of patients at high cardiometabolic risk. C1 [Patti, Angelo M.; Nikolic, Dragana; Giglio, Rosaria, V; Terranova, Antonino; Soresi, Maurizio; Giannitrapani, Lydia; Montalto, Giuseppe; Rizzo, Manfredi] Univ Palermo, Dept Hlth Promot Sci Maternal & Infantile Care In, I-90127 Palermo, Italy. [Carruba, Giuseppe] ARNAS Civ Cristina & Benfratelli Hosp, Div Res & Internationalizat, I-90127 Palermo, Italy. [Cicero, Arrigo F. G.] Univ Bologna, Med & Surg Sci Dept, I-40138 Bologna, Italy. [Banach, Maciej] Med Univ Lodz, Dept Hypertens, Chair Nephrol & Hypertens, PL-90419 Lodz, Poland. [Banach, Maciej] Polish Mothers Mem Hosp Res Inst PMMHRI Lodz, PL-93338 Lodz, Poland. [Stoian, Anca Pantea] Carol Davila Univ Med & Pharm, Dept Diabet Nutr & Metab Dis, Bucharest 050474, Romania. [Banerjee, Yajnavalka] Mohammed Bin Rashid Univ Med & Hlth Sci, Dubai 505055, U Arab Emirates. [Rizvi, Ali A.; Rizzo, Manfredi] Univ South Carolina, Div Endocrinol Diabet & Metab, Sch Med, Columbia, SC 29203 USA. [Rizvi, Ali A.] Emory Univ, Div Endocrinol Metab & Lipids, Sch Med, Atlanta, GA 30322 USA. [Toth, Peter P.] CGH Med Ctr, Sterling, IL 61081 USA. [Toth, Peter P.] Univ Illinois, Sch Med, Peoria, IL 60612 USA. [Toth, Peter P.] Johns Hopkins Univ, Sch Med, Baltimore, MD 21205 USA. C3 University of Palermo; A.R.N.A.S. Ospedali Civico Di Cristina Benfratelli; University of Bologna; Medical University Lodz; Carol Davila University of Medicine & Pharmacy; University of South Carolina System; University of South Carolina Columbia; Emory University; University of Illinois System; University of Illinois Peoria; Johns Hopkins University RP Nikolic, D (通讯作者)，Univ Palermo, Dept Hlth Promot Sci Maternal & Infantile Care In, I-90127 Palermo, Italy. EM pattiangelomaria@gmail.com; giuseppe.carruba@arnascivico.it; arrigo.cicero@unibo.it; Maciej.banach@iczmp.edu.pl; dragana.nikolic@unipa.it; toninoterranova@unipa.it; maurizio.soresi@unipa.it; lydiagiannitp@gmail.com; giuseppe.montalto@unipa.it; ancastoian@yahoo.com; Yajnavalka.Banerjee@mbru.ac.ae; ali.abbas.rizvi@emory.edu; peter.toth@cghmc.com; manfredi.rizzo@unipa.it RI GIGLIO, Rosaria Vincenza/IAR-9444-2023; Pantea Stoian, Anca/H-5799-2017; Banerjee, Yajnavalka/J-5890-2019; Cicero, Arrigo Francesco Giuseppe/H-8244-2019; Carruba, Giuseppe/AAB-5833-2022; Banach, Maciej/A-1271-2009; Giannitrapani, Lydia/I-3706-2019; Toth, Peter/GMW-6552-2022; RIZZO, Manfredi/GZL-0551-2022; Rizvi, Ali/AFV-2240-2022 OI GIGLIO, Rosaria Vincenza/0000-0002-7968-1480; Pantea Stoian, Anca/0000-0003-0555-526X; Soresi, Maurizio/0000-0001-7850-555X; Banerjee, Yajnavalka/0000-0002-7546-8893; Cicero, Arrigo Francesco Giuseppe/0000-0002-4367-3884; Carruba, Giuseppe/0000-0002-7872-1436; Nikolic, agana/0000-0001-9572-9651; Giannitrapani, Lydia/0000-0003-2845-5296; RIZZO, Manfredi/0000-0002-9549-8504; FU project DiMeSa (Dieta Mediterranea e Salute) "Valorisation of typical products of Mediterranean Diet and their use for health and nutraceutic aims" [PON02_00451_3361785]; National Operative Programme (PON) Research and Competitiveness [713/Ric]; Ministry of Education, University and Research (MIUR) FX The authors want to thank Amedeo Bonfiglio, Giuseppa Castellino and Roberta Chianetta from PROMISE Department, University of Palermo, Italy, for their valuable contribution in a few steps of this study, as well as all the volunteers who participated in this trial. We are grateful to Nicola Locorotondo and Valentina Mistretta for their valuable contribution in the laboratory work. Part of this work was carried out using instruments provided by project DiMeSa (Dieta Mediterranea e Salute) "Valorisation of typical products of Mediterranean Diet and their use for health and nutraceutic aims", PON02_00451_3361785. This project is funded in the frame of National Operative Programme (PON) Research and Competitiveness 2007-2013, Notice 713/Ric. the Ministry of Education, University and Research (MIUR), Axis I-Support to structural changes, Operational Objective-Networks to strengthen the scientific and technological potential of Convergence Regions, The Action: High Technology Clusters and Related Networks. 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METABOLITES JI Metabolites PD OCT PY 2020 VL 10 IS 10 AR 392 DI 10.3390/metabo10100392 PG 14 WC Biochemistry & Molecular Biology WE Science Citation Index Expanded (SCI-EXPANDED) SC Biochemistry & Molecular Biology GA OM7LM UT WOS:000586201300001 PM 33023123 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Sood, S Sylivris, AL Sualeheen, A Scott, D Tan, SY Villani, A Baguley, BJ Abbott, G Kiss, N Daly, RM George, ES AF Sood, Surbhi Sylivris, Amy Lauren Sualeheen, Ayesha Scott, David Tan, Sze-Yen Villani, Anthony Baguley, Brenton J. Abbott, Gavin Kiss, Nicole Daly, Robin M. George, Elena S. TI The effects of Mediterranean diet with and without exercise on body composition in adults with chronic disease: A systematic review and meta-analysis of clinical trials SO CLINICAL NUTRITION LA English DT Review DE Body composition; Mediterranean diet; Hypocaloric; Chronic disease; Exercise ID WEIGHT-LOSS INTERVENTIONS; CORONARY-HEART-DISEASE; FATTY LIVER-DISEASE; CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; PHYSICAL-ACTIVITY; VISCERAL FAT; LIFE-STYLE; OVERWEIGHT; PREVENTION AB Background & aims: The Mediterranean diet (MedDiet), with and without energy restriction, has been associated with reduced risk of numerous chronic diseases, including type 2 diabetes and cardiovascular disease. Exercise is well known to improve various health outcomes in individuals with chronic diseases and emerging evidence indicates that combining diet and exercise may be superior to individual interventions. The primary aim of this systematic review and meta-analysis was to assess the effects of all MedDiet interventions (regardless of exercise or energy restriction), as well as MedDiet alone (and in hypocaloric and isocaloric subgroups) on body composition outcomes [weight, waist circumference (WC), body mass index (BMI), body fat (BF), lean mass (LM) and visceral adipose tissue (VAT)] in adults with chronic disease. Secondary aims were to assess the effects of MedDiet plus exercise, including in hypocaloric and isocaloric subgroups, on body composition outcomes. Methods: Four electronic databases (ProQuest, Medline, Embase and CINAHL) were searched from inception to January 2025. Randomised controlled trials including MedDiet interventions in adults with chronic diseases that assessed body composition as outcomes were included. Outcomes were pooled using random-effect meta-analysis for MedDiet interventions compared with controls to determine the standardised mean difference. Results: Twenty papers were included in the systematic review and meta-analysis, reporting data from 17 unique studies. Reductions in BMI (SMD = -1.21, P = 0.01) and VAT (SMD = -0.12, P = 0.02) and improvements in LM (SMD = 0.11, P = 0.01) were found in meta-analytic models including all MedDiet interventions (regardless of exercise or energy restriction). MedDiet alone did not result in significant changes in any body composition outcomes. Interventions combining MedDiet plus exercise had statistically significant effects on reducing weight (SMD = -0.19), BMI (SMD = -0.27), WC (SMD = -0.39), BF (SMD = -0.13) and VAT (SMD = -0.12), with all P < 0.05. Although effect sizes were small, the estimated absolute reductions were approximately 2.5 kg in weight, 1.0 kg/m(2) in BMI, 3.5 cm in WC and 102 g in VAT, based on SD reported previously in the literature. Subgroup analysis showed that hypocaloric MedDiet plus exercise significantly reduced BMI (SMD = -0.24, P = 0.01), BF (SMD = -0.13, P = 0.01), and VAT (SMD = -0.12, P = 0.02), while isocaloric MedDiet with exercise led to significant reductions in weight (SMD = -0.18, P = 0.04), BMI (SMD = -0.24, P = 0.02), and WC (SMD = -0.32, P = 0.0) relative to controls. Conclusion: MedDiet interventions (regardless of exercise or energy restriction) led to improvements in BMI, LM and VAT. MedDiet in combination with exercise, with or without energy restriction improved all body composition outcomes, with the exception of LM. These novel findings highlight the potential importance of a multimodal intervention, integrating the MedDiet with exercise for chronic disease management. (c) 2025 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). C1 [Sood, Surbhi; Sualeheen, Ayesha; Scott, David; Tan, Sze-Yen; Baguley, Brenton J.; Abbott, Gavin; Kiss, Nicole; Daly, Robin M.; George, Elena S.] Deakin Univ, Inst Phys Act & Nutr, Sch Exercise & Nutr Sci, Melbourne, Vic, Australia. [Sylivris, Amy Lauren; Scott, David] Monash Univ, Sch Clin Sci, Dept Med, Melbourne, Vic, Australia. [Villani, Anthony] Univ Sunshine Coast, Sch Hlth, Sunshine Coast, Qld, Australia. C3 Deakin University; Monash University; University of the Sunshine Coast RP George, ES (通讯作者)，Deakin Univ, Inst Phys Act & Nutr IPAN, Sch Exercise & Nutr Sci, Melbourne, Vic 3125, Australia. EM elena.george@deakin.edu.au RI Daly, Robin/AAN-2353-2020; Scott, David/AAE-5031-2021; Tan, Sze/H-5796-2019; Baguley, Brenton/Y-3570-2019; George, Elena/J-3357-2019 OI Sualeheen, Ayesha/0000-0002-1391-9644; Sood, Surbhi/0000-0002-5671-4817; Villani, Anthony/0000-0003-4891-1076; Sylivris, Amy/0000-0003-2539-7561; FU Deakin University, Faculty of Health, Doctor of Philosophy scholarship FX Surbhi Sood was supported by Deakin University, Faculty of Health, Doctor of Philosophy scholarship. 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Nutr. PD AUG PY 2025 VL 51 BP 222 EP 239 DI 10.1016/j.clnu.2025.06.019 EA AUG 2025 PG 18 WC Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Nutrition & Dietetics GA 4XJ0Z UT WOS:001528919500001 PM 40614654 OA hybrid DA 2026-02-02 ER PT J AU Pousis, C Rodríguez, C De Ruvo, P De Virgilio, C Pérez, JA Mylonas, CC Zupa, R Passantino, L Santamaria, N Valentini, L Corriero, A AF Pousis, Chrysovalentinos Rodriguez, Covadonga De Ruvo, Pasquale De Virgilio, Caterina Perez, Jose A. Mylonas, Constantinos C. Zupa, Rosa Passantino, Letizia Santamaria, Nicoletta Valentini, Luisa Corriero, Aldo TI Vitellogenin receptor and fatty acid profiles of individual lipid classes of oocytes from wild and captive-reared greater amberjack (Seriola dumerili) during the reproductive cycle SO THERIOGENOLOGY LA English DT Article DE Osteichthyes; Mediterranean sea; Oogenesis; Vitellogenesis; Reproduction; Reproductive dysfunctions; Phospholipids ID LOW-DENSITY-LIPOPROTEIN; LIGAND-BINDING REPEATS; ARACHIDONIC-ACID; RAINBOW-TROUT; BLUEFIN TUNA; OVARIAN-FOLLICLES; BROODSTOCK DIETS; MARINE TELEOST; RISSO 1810; EXPRESSION AB The greater amberjack Seriola dumerili (Risso, 1810) is a large migratory pelagic fish occurring in tropical and temperate waters with a great potential for the world aquaculture industry. Previous studies showed that wild-caught female greater amberjack reared in sea cages and handled during the reproductive season, underwent extensive ovarian atresia. This atresia, however, was not related to an insufficient liver transcription or oocyte uptake of vitellogenin (Vtg). In the present study, the structure of two greater amberjack vitellogenin receptors, namely Vtgr (Lr8-) and Lrp13, was characterized. Moreover, vtgr and lrp13 gene expression and the fatty acid profiles of specific phospholipids and neutral lipids were compared in the ovaries of wild and captive-reared greater amberjack during different phases of the reproductive cycle (i.e. early gametogenesis, advanced gametogenesis and spawning). Ovarian vtgr and lrp13 transcription was more active during early gametogenesis, suggesting that vitellogenin receptor transcripts were synthesized by previtellogenic oocytes and remained in the cellular mRNA pool until oocytes resumed meiosis and entered into secondary growth (i.e. vitellogenesis). Rearing of wild-caught greater amberjack in captivity together with handling during the reproductive season was associated with a reduced vtgr and lrp13 transcription and with a diminished capacity of oocytes in the early phase of gametogenesis (primary oocyte growth) to enter into vitellogenesis. During early gametogenesis, remarkable differences in the fatty acid composition were observed between wild and captive-reared individuals: all phospholipids of captive fish displayed dramatic increases of saturates (16:0 and 18:0) and decreases of arachidonic acid (ARA) and docosahexaenoic acid (DHA). The present study confirms the susceptibility of greater amberjack reproductive function to handling stress and suggests that the consequent extensive atresia of vitellogenic follicles originated during the primary oocytes growth when the capacity of oocytes to synthesize vitellogenin receptors was reduced. The study also suggests that this reduced capacity was associated with an altered oocyte phospholipid fatty acid composition during early gametogenesis. (C) 2019 Elsevier Inc. All rights reserved. C1 [Pousis, Chrysovalentinos; Zupa, Rosa; Passantino, Letizia; Santamaria, Nicoletta; Valentini, Luisa; Corriero, Aldo] Univ Bari Aldo Moro, Sect Vet Clin & Anim Prod, Dept Emergency & Organ Transplantat, SP Casamassima Km 3, I-70010 Bari, Italy. [Rodriguez, Covadonga; Perez, Jose A.] Univ La Laguna, Fac Ciencias, Dept Biol Anim Edafol & Geol, Avda Astrofis Francisco Sanchez S-N, Tenerife 38071, Spain. [De Ruvo, Pasquale; De Virgilio, Caterina] Univ Bari Aldo Moro, Dept Biosci Biotechnol & Biopharmaceut, Via E Orabona 4, I-70124 Bari, Italy. [Mylonas, Constantinos C.] Hellen Ctr Marine Res, Inst Marine Biol Biotechnol & Aquaculture, POB 2214, Iraklion 71003, Crete, Greece. C3 Universita degli Studi di Bari Aldo Moro; Universidad de la Laguna; Universita degli Studi di Bari Aldo Moro; Hellenic Centre for Marine Research RP Corriero, A (通讯作者)，Univ Bari Aldo Moro, Sect Vet Clin & Anim Prod, Dept Emergency & Organ Transplantat, SP Casamassima Km 3, I-70010 Bari, Italy. EM aldo.corriero@uniba.it RI Zupa, Rosa/ABE-9966-2021; Corriero, Aldo/AAH-1542-2021; Mylonas, Constantinos/G-9196-2011; Pérez Pérez, José Antonio/L-4293-2014; Rodríguez González, Covadonga/L-5173-2014 OI Corriero, Aldo/0000-0001-7068-9438; DE VIRGILIO, Caterina/0000-0003-3929-3691; Pérez Pérez, José Antonio/0000-0002-5662-7246; Rodríguez González, Covadonga/0000-0002-2805-0048 FU European Union [KBBE-2013-07, GA 603121] FX This project has received funding from the European Union's Seventh Framework Programme for research, technological development and demonstration (KBBE-2013-07 single stage, GA 603121, DIVERSIFY) to AC, CCM and CR. 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Theriogenology PD DEC PY 2019 VL 140 BP 73 EP 83 DI 10.1016/j.theriogenology.2019.08.014 PG 11 WC Reproductive Biology; Veterinary Sciences WE Science Citation Index Expanded (SCI-EXPANDED) SC Reproductive Biology; Veterinary Sciences GA JH0TZ UT WOS:000492488000011 PM 31465910 OA Green Submitted DA 2026-02-02 ER PT J AU Colica, C Merra, G Gasbarrini, A De Lorenzo, A Cioccoloni, G Gualtieri, P Perrone, MA Bernardini, S Bernardo, V Di Renzo, L Marchetti, M AF Colica, C. Merra, G. Gasbarrini, A. De Lorenzo, A. Cioccoloni, G. Gualtieri, P. Perrone, M. A. Bernardini, S. Bernardo, V. Di Renzo, L. Marchetti, M. TI Efficacy and safety of very-low-calorie ketogenic diet: a double blind randomized crossover study SO EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES LA English DT Article DE Very-low-calorie; Ketogenic Diet; Randomized crossover clinical trial; Obesity; Body Composition; Vitamin D; PPAR gamma ID SERUM 25-HYDROXYVITAMIN D; FATTY LIVER-DISEASE; CARDIOVASCULAR RISK-FACTORS; LOW-CARBOHYDRATE DIETS; VITAMIN-D DEFICIENCY; WEIGHT-LOSS; METABOLIC SYNDROME; INSULIN-RESISTANCE; MEDITERRANEAN DIET; BODY-COMPOSITION AB OBJECTIVE: To verify safety respect to weight loss, cardiometabolic diseases of short-term Very low-calorie ketogenic diets (VLCKDs, <800 kcal day-1). PATIENTS AND METHODS: Randomized cross-over trial with placebo. The study had no. 2 dietary treatment (DT), conducted in two arms: (1) VLCKD1 in which 50% of protein intake is replaced with synthetic amino acids; (2) VLCKD2 with placebo. The VLCKDs (<800 kcal day-1) were different in term of protein content and quality each arm lasted three weeks (wks). Between the two arms a 3-wks washout period was performed to avoid additive effects on DT to follow. At the baseline, at start and end of each arm, all the subjects were evaluated for their health and nutritional status, by anthropometric analysis, body composition (Dual X-ray Absorptiometry (DXA), Bioimpedentiometry, biochemical evaluation, and Peroxisome Proliferator-Activated Receptor. (PPAR). expression by transcriptomic analysis. RESULTS: After VLCKD1 were reduced: Body Mass Index (BMI) (triangle%=-11.1%, p= 0.00), Total Body Water (TBW) (p< 0.05); Android Fat Percentage (AFP) (triangle%=-1.8%, p= 0.02); Android Fat Mass (AFM) (triangle%=-12.7%, p= 0.00); Gynoid Fat Mass (GFM) (triangle%=-6.3%, p= 0.01); Intermuscular Adipose Tissue (IMAT) (triangle%= -11.1%, p= 0.00); Homeostasis Model Assessment of Insulin Re-sistance (HOMA-IR) (triangle%=-62.1%, p= 0.01). After VLCKD1 a significant increase of uricemia, cre-atinine and aspartate aminotransferase (AST) (respectively triangle%= 35%, p= 0.01; triangle%= 5.9%, p= 0.02; triangle%= 25.5%, p= 0.03). After VLCKD2 were reduced: BMI (triangle%=11.2%, p= 0.00); AFM (triangle%=-14.3%, p= 0.00); GFM (triangle%=-6.3%, p= 0.00); Appendicular Skeletal Muscle Mass Index (ASMMI) (triangle%=-17.5%, p= 0.00); HOMA-IR (triangle%=-59,4%, p= 0.02). After VLCKD2, uricemia (triangle%= 63.1%, p= 0.03), and Vitamin D levels (triangle%= 25.7%, p= 0.02) were increased. No significant changes of car-diovascular disease (CVD) indexes were observed after DTs. No significant changes of PPAR. lev-el in any DTs. CONCLUSIONS: 21-days VLCKDs not impair nutritional state; not cause negative changes in global measurements of nutritional state including sarcopenia, bone mineral content, hepatic, renal and lipid profile. C1 [Colica, C.] Magna Graecia Univ Catanzaro, CNR, IBFM UOS Germaneto, Campus Salvatore Venuta, Catanzaro, Italy. [Merra, G.] Univ Cattolica Sacro Cuore, Dept Emergency Med, Polyclin Gemelli Fdn, Rome, Italy. [Gasbarrini, A.] Univ Cattolica Sacro Cuore, Div Internal Med & Gastroenterol, Polyclin Gemelli Fdn, Rome, Italy. [De Lorenzo, A.; Di Renzo, L.] Univ Roma Tor Vergata, Dept Biomed & Prevent, Sect Clin Nutr & Nutrigen, Rome, Italy. [Cioccoloni, G.; Gualtieri, P.] Univ Roma Tor Vergata, Sch Med Surg Appl Sci, Rome, Italy. [Perrone, M. A.; Bernardini, S.] Univ Roma Tor Vergata, Div Clin Biochem & Clin Mol Biol, Rome, Italy. [Perrone, M. A.] Univ Roma Tor Vergata, Div Cardiol, Rome, Italy. [Bernardo, V.] San Camillo de Lellis Hosp, Rieti, Italy. [Marchetti, M.] Sapienza Univ Rome, Dept Surg Sci, Policlin Umberto 1, Rome, Italy. [Marchetti, M.] USL 1 Umbria, Perugia, Italy. C3 Consiglio Nazionale delle Ricerche (CNR); Magna Graecia University of Catanzaro; Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli; Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli; University of Rome Tor Vergata; University of Rome Tor Vergata; University of Rome Tor Vergata; University of Rome Tor Vergata; Sapienza University Rome; University Hospital Sapienza Rome RP Merra, G (通讯作者)，Univ Cattolica Sacro Cuore, Dept Emergency Med, Polyclin Gemelli Fdn, Rome, Italy. EM giuseppe.merra@policlinicogemelli.it RI Gasbarrini, Antonio/AAB-8487-2019; Gualtieri, Paola/AAS-1684-2020; Gasbarrini, Antonio/AAB-8487-2019; di renzo, laura/ACB-2003-2022; Merra, Giuseppe/M-5003-2015; Colica, Carmela/AAY-4131-2020 OI Gasbarrini, Antonio/0000-0002-6230-1779; Gualtieri, Paola/0000-0003-1533-4276; Gasbarrini, Antonio/0000-0003-4863-6924; marchetti, marco/0000-0002-7236-1417; di renzo, laura/0000-0001-8875-6723; Merra, Giuseppe/0000-0003-4753-3528; Cioccoloni, Giorgia/0000-0003-0102-9182; De Lorenzo, Antonino/0000-0001-6524-4493 FU Ministry of Agriculture, Food and Forestry [2017188] FX Supported by grants from Ministry of Agriculture, Food and Forestry (D.M.: 2017188 03/24/2011). 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Rev. Med. Pharmacol. Sci. PD MAY PY 2017 VL 21 IS 9 BP 2274 EP 2289 PG 16 WC Pharmacology & Pharmacy WE Science Citation Index Expanded (SCI-EXPANDED) SC Pharmacology & Pharmacy GA EV9YU UT WOS:000402144600037 PM 28537652 DA 2026-02-02 ER PT J AU Rachwal, K Mierczak, K Poplawski, T AF Rachwal, K. Mierczak, K. Poplawski, T. TI The Potential Benefits of Akkermansia muciniphila as a Next-Generation Probiotic in the Maintenance of Overall Liver Health SO ACTA GASTRO-ENTEROLOGICA BELGICA LA English DT Article DE Akkermansia muciniphila; Liver diseases;; NAFLD; gut microbiota; probiotic ID MEDITERRANEAN DIET; DISEASE; MICROBIOTA; MUCIN; INDIVIDUALS; ASSOCIATION; CONSUMPTION; INTEGRITY; CIRRHOSIS; WEIGHT AB Background and study aim: The gut-liver axis and gut microbiota, with a particular focus on Akkermansia muciniphila, a next-generation probiotic, have been identified as significant factors in preventing the development and progression of liver diseases. This review aims to discuss the potential therapeutic role of A. muciniphila in maintaining liver health, focusing on the latest findings from preclinical and clinical studies. Methods: To achieve the review's purpose, the most common keywords were searched in three online databases (PubMed, bioRxiv, and Google Scholar). Results: The search approach identified 49 references. Studies have shown that the gut microbiota, including A. muciniphila, has the potential to be a therapeutic target for many hepatic disorders. Several studies have demonstrated A. muciniphila's beneficial effects on improving metabolic parameters, including insulin resistance, blood cholesterol levels, and overall liver function. Conclusions: Further research is necessary to determine the optimal dosage, duration, and administration route of A. muciniphila for managing hepatic disorders. While there are promising findings, a more thorough understanding of the underlying mechanisms and the development of effective therapeutic strategies are necessary for successful treatment of liver diseases. (Acta gastroenterol belg., 2025, 88, 141-150 C1 [Rachwal, K.] Med Univ Siles, Fac Med Katowice, Medykow 18, PL-40752 Katowice, Poland. [Mierczak, K.; Poplawski, T.] Med Univ Lodz, Dept Microbiol & Pharmaceut Biochem, Mazowiecka 5, PL-92215 Lodz, Poland. C3 Medical University of Silesia; Medical University Lodz RP Rachwal, K (通讯作者)，Med Univ Siles, Fac Med Katowice, Medykow 18, PL-40752 Katowice, Poland. 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PD APR-JUN PY 2025 VL 88 IS 2 BP 141 EP 150 DI 10.51821/88.1.13037 PG 10 WC Gastroenterology & Hepatology WE Science Citation Index Expanded (SCI-EXPANDED) SC Gastroenterology & Hepatology GA 3OL7O UT WOS:001505211400001 PM 40504581 DA 2026-02-02 ER PT J AU Natalucci, V Virgili, E Calcagnoli, F Valli, G Agostini, D Zeppa, SD Barbieri, E Emili, R AF Natalucci, Valentina Virgili, Edy Calcagnoli, Federica Valli, Giacomo Agostini, Deborah Zeppa, Sabrina Donati Barbieri, Elena Emili, Rita TI Cancer Related Anemia: An Integrated Multitarget Approach and Lifestyle Interventions SO NUTRIENTS LA English DT Review DE cancer-related anemia; iron supplementation; hepcidin; gut microbiota; lifestyle ID NF-KAPPA-B; REGULATORY T-CELLS; QUALITY-OF-LIFE; POLYUNSATURATED FATTY-ACIDS; RANDOMIZED CLINICAL-TRIAL; GLYCATION END-PRODUCTS; CHRONIC KIDNEY-DISEASE; LOW-GRADE INFLAMMATION; NECROSIS-FACTOR-ALPHA; GUT MICROBIOTA AB Cancer is often accompanied by worsening of the patient's iron profile, and the resulting anemia could be a factor that negatively impacts antineoplastic treatment efficacy and patient survival. The first line of therapy is usually based on oral or intravenous iron supplementation; however, many patients remain anemic and do not respond. The key might lie in the pathogenesis of the anemia itself. Cancer-related anemia (CRA) is characterized by a decreased circulating serum iron concentration and transferrin saturation despite ample iron stores, pointing to a more complex problem related to iron homeostatic regulation and additional factors such as chronic inflammatory status. This review explores our current understanding of iron homeostasis in cancer, shedding light on the modulatory role of hepcidin in intestinal iron absorption, iron recycling, mobilization from liver deposits, and inducible regulators by infections and inflammation. The underlying relationship between CRA and systemic low-grade inflammation will be discussed, and an integrated multitarget approach based on nutrition and exercise to improve iron utilization by reducing low-grade inflammation, modulating the immune response, and supporting antioxidant mechanisms will also be proposed. Indeed, a Mediterranean-based diet, nutritional supplements and exercise are suggested as potential individualized strategies and as a complementary approach to conventional CRA therapy. C1 [Natalucci, Valentina; Agostini, Deborah; Zeppa, Sabrina Donati; Barbieri, Elena] Univ Urbino Carlo Bo, Dept Biomol Sci, I-61029 Urbino, Italy. [Virgili, Edy; Calcagnoli, Federica] Univ Camerino, Sch Biosci & Vet Med, I-62032 Camerino, Italy. [Valli, Giacomo] Univ Padua, Dept Biomed Sci, Neuromuscular Physiol Lab, I-35131 Padua, Italy. [Emili, Rita] Osped Santa Maria Misericordia Urbino, UOC Oncol Med, ASUR Area Vasta 1, I-61029 Urbino, Italy. C3 University of Urbino; University of Camerino; University of Padua RP Zeppa, SD; Barbieri, E (通讯作者)，Univ Urbino Carlo Bo, Dept Biomol Sci, I-61029 Urbino, Italy. 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Nutrients PD FEB PY 2021 VL 13 IS 2 AR 482 DI 10.3390/nu13020482 PG 36 WC Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Nutrition & Dietetics GA QO0WW UT WOS:000622869900001 PM 33535496 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Quagliariello, V Berretta, M Bisceglia, I Giacobbe, I Iovine, M Barbato, M Maurea, C Canale, ML Paccone, A Inno, A Scherillo, M Oliva, S Dessalvi, CC Mauriello, A Fonderico, C Maratea, AC Gabrielli, D Maurea, N AF Quagliariello, Vincenzo Berretta, Massimiliano Bisceglia, Irma Giacobbe, Ilaria Iovine, Martina Barbato, Matteo Maurea, Carlo Canale, Maria Laura Paccone, Andrea Inno, Alessandro Scherillo, Marino Oliva, Stefano Dessalvi, Christian Cadeddu Mauriello, Alfredo Fonderico, Celeste Maratea, Anna Chiara Gabrielli, Domenico Maurea, Nicola TI In the Era of Cardiovascular-Kidney-Metabolic Syndrome in Cardio-Oncology: From Pathogenesis to Prevention and Therapy SO CANCERS LA English DT Review DE metabolic syndrome; kidney diseases; cancer; cardio-oncology; cardiotoxicity; metabolism; PCSK9; obesity ID SOLUBLE GUANYLATE-CYCLASE; LOW-GLYCEMIC INDEX; ANGIOTENSIN-ALDOSTERONE SYSTEM; FATTY LIVER-DISEASE; MEDITERRANEAN DIET; INSULIN-RESISTANCE; RECEPTOR AGONISTS; OXIDATIVE STRESS; RISK; HYPERTENSION AB Cardiovascular-kidney-metabolic (CKM) syndrome represents a complex interplay between cardiovascular disease (CVD), chronic kidney disease (CKD), and metabolic disorders, significantly impacting cancer patients. The presence of CKM syndrome in cancer patients not only worsens their prognosis but also increases the risk of major adverse cardiovascular events (MACE), reduces quality of life (QoL), and affects overall survival (OS). Furthermore, several anticancer therapies, including anthracyclines, tyrosine kinase inhibitors, immune checkpoint inhibitors, and hormonal treatments, can exacerbate CKM syndrome by inducing cardiotoxicity, nephrotoxicity, and metabolic dysregulation. This review explores the pathophysiology of CKM syndrome in cancer patients and highlights emerging therapeutic strategies to mitigate its impact. We discuss the role of novel pharmacological interventions, including sodium-glucose cotransporter-2 inhibitors (SGLT2i), proprotein convertase subtilisin/kexin type 9 inhibitors (PCSK9i), and soluble guanylate cyclase (sGC) activators, as well as dietary and lifestyle interventions. Optimizing the management of CKM syndrome in cancer patients is crucial to improving OS, enhancing QoL, and reducing MACE. By integrating cardiometabolic therapies into oncologic care, we can create a more comprehensive treatment approach that reduces the burden of cardiovascular and renal complications in this vulnerable population. Further research is needed to establish personalized strategies for CKM syndrome prevention and treatment in cancer patients. C1 [Quagliariello, Vincenzo; Giacobbe, Ilaria; Iovine, Martina; Barbato, Matteo; Paccone, Andrea; Mauriello, Alfredo; Fonderico, Celeste; Maratea, Anna Chiara; Maurea, Nicola] IRCCS Fdn G Pascale, Ist Nazl Tumori, Div Cardiol, I-80131 Naples, Italy. [Berretta, Massimiliano] Univ Messina, Dept Clin & Expt Med, I-98125 Messina, Italy. [Bisceglia, Irma] Azienda Osped San Camillo Forlanini, Dipartimento Cardiotoracovasc, Servizi Cardiol Integrati, I-00148 Rome, Italy. [Maurea, Carlo] Osped Mare, UOC Neurol & Stroke Unit, ASL NA1, I-23807 Naples, Italy. [Canale, Maria Laura] Osped Versilia, UOC Cardiol, I-55041 Lido Di Camaiore, Italy. [Inno, Alessandro] IRCCS Osped Sacro Cuore Don Calabria, Med Oncol, I-37024 Negrar Di Valpolicella, Italy. [Scherillo, Marino] AO San Pio, Cardiol Interventist & UTIC, Presidio Osped Gaetano Rummo, I-82100 Benevento, Italy. [Oliva, Stefano] IRCCS Ist Tumori Giovanni Paolo II, Cardiooncol Unit, I-70124 Bari, Italy. [Dessalvi, Christian Cadeddu] Univ Cagliari, Dept Med Sci & Publ Hlth, I-09123 Cagliari, Italy. [Gabrielli, Domenico] Azienda Osped San Camillo Forlanini, Dipartimento Cardiotoracovasc, UOC Cardiol, I-00152 Rome, Italy. C3 Fondazione IRCCS Istituto Nazionale Tumori Milan; IRCCS Fondazione Pascale; University of Messina; Azienda Ospedaliera San Camillo-Forlanini; Ospedale Versilia; IRCCS Istituto Tumori Bari Giovanni Paolo II; University of Cagliari; Azienda Ospedaliera San Camillo-Forlanini RP Quagliariello, V (通讯作者)，IRCCS Fdn G Pascale, Ist Nazl Tumori, Div Cardiol, I-80131 Naples, Italy. EM quagliariello.enzo@gmail.com RI ; Quagliariello, Vincenzo/GLT-0763-2022; Berretta, Massimiliano/S-5853-2019; Maurea, Nicola/AAC-2341-2022; Inno, Alessano/AAA-8268-2022; Gabrielli, Domenico/AAC-1130-2022; Cadeddu, Christian/AAI-9219-2020; Iovine, Martina/ABD-8951-2020; Caturano, Alfredo/AAA-4014-2022 OI Maurea, Carlo/0000-0001-9634-1640; Quagliariello, Vincenzo/0000-0002-4557-5401; Berretta, Massimiliano/0000-0002-9837-9148; Maurea, Nicola/0000-0003-3704-0092; , Alfredo/0000-0001-7060-6938; Oliva, Stefano/0000-0002-3200-2372; Fonderico, Celeste/0009-0006-5648-4552; Inno, Alessano/0000-0001-6331-6908; Gabrielli, Domenico/0000-0003-3392-0527; Cadeddu, Christian/0000-0002-2823-1797; bisceglia, irma/0000-0002-0689-0695; FU The 5 x 1000 Project (5XMILLE_2022_17) titled "Inibitori selettivi di PCSK9 e NLRP3 come strategie preventive della cardiotossicita e aterosclerosi indotta da farmaci antitumorali: impatto del targeting lipidico ed infiammatorio in Cardio-Oncologia" - Mini FX This research was funded by the 5 x 1000 Project (5XMILLE_2022_17) titled "Inibitori selettivi di PCSK9 e NLRP3 come strategie preventive della cardiotossicita e aterosclerosi indotta da farmaci antitumorali: impatto del targeting lipidico ed infiammatorio in Cardio-Oncologia", funded by Ministro della Salute. 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Navarro, Maria Angeles Osada, Jesus Fernandes, Susana C. M. TI Chitosan Nanoparticles, a Novel Drug Delivery System to Transfer Squalene for Hepatocyte Stress Protection SO ACS OMEGA LA English DT Article ID CELLULAR UPTAKE; ANTIBACTERIAL ACTIVITY; SURFACE-CHARGE; PARTICLE-SIZE; CHITIN; OIL; BIOTECHNOLOGY; DERIVATIVES; MODULATION; PATHWAYS AB The Mediterranean diet is a well-known dietary pattern that has gained considerable popularity worldwide for its ability to prevent the progression of nonalcoholic fatty liver disease. This is largely attributed to the use of virgin olive oil as the primary source of fat, which contains a substantial amount of squalene, a natural antioxidant. In order to enhance the delivery of squalene and amplify its effects due to its highly hydrophobic nature, herein, squalene has been incorporated into chitosan nanoparticles. The characterization of the resulting nanoparticles was conducted via scanning electron microscopy, dynamic light scattering, zeta potential, Fourier transform infrared spectroscopy, and gas chromatography-mass spectrometry. Reactive oxygen species (ROS) generation and cell viability assays were conducted in oxidative and endoplasmic reticulum (ER) stress in AML12 and a TXNDC5-deficient AML12 cell line, which was generated by CRISPR/Cas9 technology. The results demonstrated that squalene was successfully encapsulated in chitosan nanoparticles and exhibited rapid and efficient cellular uptake at a 150 mu M squalene concentration within 48 h. In conclusion, the encapsulation of squalene in chitosan nanoparticles, compared to the poly(d,l-lactide-co-glycolic acid) and ethanol drug carriers, significantly enhanced its cellular uptake. This allows the administration of higher doses, which improve hepatocyte viability and reduce ROS levels, effectively compensating for the adverse effects of TXNDC5 deficiency under the context of hepatocyte stress protection. C1 [Bidooki, Seyed Hesamoddin; Sanchez-Marco, Javier; Martinez-Beamonte, Roberto; Navarro, Maria Angeles; Osada, Jesus] Univ Zaragoza, Inst Invest Sanitaria Aragon, Fac Vet, Dept Bioquim & Biol Mol & Celular, E-50013 Zaragoza, Spain. [Bidooki, Seyed Hesamoddin; Spitzer, Lea; Petitpas, Arnaud; Pellerin, Virginie; Fernandes, Susana C. M.] Univ Pau & Pays Adour, Inst Analyt Sci & Physico Chem Environm & Mat IPRE, CNRS, E2S UPPA, F-64012 Pau, France. [Bidooki, Seyed Hesamoddin; Spitzer, Lea; Petitpas, Arnaud; Fernandes, Susana C. M.] Univ Pau & Pays Adour, MANTA Marine Mat Res Grp, F-64053 Pau, France. [Martinez-Beamonte, Roberto; Rodriguez-Yoldi, Maria J.; Navarro, Maria Angeles; Osada, Jesus] Univ Zaragoza, CITA, Inst Agroalimentario Aragon, E-50013 Zaragoza, Spain. [Martinez-Beamonte, Roberto; Rodriguez-Yoldi, Maria J.; Navarro, Maria Angeles; Osada, Jesus] Inst Salud Carlos III, Ctr Invest Biomed Red Fisiopatol Obes & Nutr CIBER, E-28029 Madrid, Spain. [Lasheras, Roberto] Serv Segur Agroalimentaria Direcc Gen Alimentac &, Gobierno Aragon, Lab Agroambiental, E-50192 Zaragoza, Spain. [Rodriguez-Yoldi, Maria J.; Osada, Jesus] Univ Zaragoza, Fac Vet, Dept Farmacol Fisiol Med Legal & Forense, E-50013 Zaragoza, Spain. C3 University of Zaragoza; Centre National de la Recherche Scientifique (CNRS); Universite de Pau et des Pays de l'Adour; Universite de Pau et des Pays de l'Adour; University of Zaragoza; Instituto de Salud Carlos III; University of Zaragoza RP Osada, J (通讯作者)，Univ Zaragoza, Inst Invest Sanitaria Aragon, Fac Vet, Dept Bioquim & Biol Mol & Celular, E-50013 Zaragoza, Spain.; Fernandes, SCM (通讯作者)，Univ Pau & Pays Adour, Inst Analyt Sci & Physico Chem Environm & Mat IPRE, CNRS, E2S UPPA, F-64012 Pau, France.; Fernandes, SCM (通讯作者)，Univ Pau & Pays Adour, MANTA Marine Mat Res Grp, F-64053 Pau, France.; Osada, J (通讯作者)，Univ Zaragoza, CITA, Inst Agroalimentario Aragon, E-50013 Zaragoza, Spain.; Osada, J (通讯作者)，Inst Salud Carlos III, Ctr Invest Biomed Red Fisiopatol Obes & Nutr CIBER, E-28029 Madrid, Spain.; Osada, J (通讯作者)，Univ Zaragoza, Fac Vet, Dept Farmacol Fisiol Med Legal & Forense, E-50013 Zaragoza, Spain. EM josada@unizar.es; susana.fernandes@univ-pau.fr RI Martinez-Beamonte, Roberto/E-4981-2016; bidooki, seyed hesamoddin/IZE-5229-2023; Navarro, Ángeles/AAG-6089-2019 OI bidooki, seyed hesamoddin/0000-0002-5612-5000; FU CIBER Fisiopatologia de la Obesidad y Nutricion as an initiative of FEDER-ISCIII [CB06/03/1012]; Ministerio de Ciencia e Innovacion-Fondo Europeo de Desarrollo Regional [PID2022-1364140B-I00]; Fondo Social Europeo-Gobierno de Aragon [B16_23R]; University of Zaragoza; University of Pau; Universidad de Zaragoza; Fundacion Bancaria Ibercaja; Fundacion CAI [CM 4/24]; The "Investissements d"Avenir' French program by ANR [ANR-16-IDEX-0002] FX This research was supported by grants (CIBEROBN, CB06/03/1012) from CIBER Fisiopatologia de la Obesidad y Nutricion as an initiative of FEDER-ISCIII, Ministerio de Ciencia e Innovacion-Fondo Europeo de Desarrollo Regional (Grant PID2022-1364140B-I00) and Fondo Social Europeo-Gobierno de Aragon (Grant B16_23R). S.H.B. was recipient of a joint fellowship from the Universities of Zaragoza and Pau and short-term fellowship from Universidad de Zaragoza, Fundacion Bancaria Ibercaja, and Fundacion CAI (Grant CM 4/24, June 4, 2024). It was also carried under the framework of E2S UPPA Partnership Chair MANTA (Marine Materials) funded by the "Investissements d"Avenir' French program managed by ANR, Grant ANR-16-IDEX-0002. 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2026-02-02 ER PT J AU Motallaei, M Ramezani-Jolfaie, N Mohammadi, M Shams-Rad, S Jahanlou, AS Salehi-Abargouei, A AF Motallaei, Maryam Ramezani-Jolfaie, Nahid Mohammadi, Mohammad Shams-Rad, Shamim Jahanlou, Alireza Shahab Salehi-Abargouei, Amin TI Effects of orange juice intake on cardiovascular risk factors: A systematic review and meta-analysis of randomized controlled clinical trials SO PHYTOTHERAPY RESEARCH LA English DT Review DE anthropometric indices; blood pressure; inflammatory markers; lipid profile; meta-analysis; orange juice ID VITAMIN-C SUPPLEMENTATION; IMPROVED NUTRIENT ADEQUACY; DENSITY-LIPOPROTEIN; MEDITERRANEAN DIET; ANTIOXIDANT STATUS; METABOLIC SYNDROME; BLOOD-PRESSURE; FATTY LIVER; CONSUMPTION; INCREASES AB Previous investigations exploring the effects of orange juice (OJ) as a nutrient-dense beverage on cardiovascular risk factors were inconsistent. We aimed to conduct a systematic review and meta-analysis of randomized controlled clinical trials to determine the effectiveness of OJ intake on major cardiometabolic markers including anthropometric indices, blood pressure, lipid profile, inflammation, and glycemic control markers. PubMed, Scopus, and ISI Web of Science were searched from inception until January 2021. Fifteen eligible trials with 639 participants were included in the present study. The meta-analysis showed that OJ intake significantly reduces circulating total cholesterol levels (10 trials; weighted mean difference [WMD] = -6.84 mg/dl; 95% CI: -12.38 to -1.29; p = .01) and homeostatic model assessment for insulin resistance (four trials; WMD = -0.39, 95% CI: -0.77 to -0.006; p = .04) compared to control group. The analyses failed to reveal a significant effect of OJ intake on other cardiometabolic risk factors (p > .05). This review suggests that the intake of OJ might be associated with improved serum total cholesterol and insulin sensitivity. Due to low-to-moderate quality of meta-evidence, our results must be interpreted with caution and more well-designed studies are still needed to confirm the current findings. C1 [Motallaei, Maryam; Shams-Rad, Shamim; Salehi-Abargouei, Amin] Shahid Sadoughi Univ Med Sci, Nutr & Food Secur Res Ctr, Yazd, Iran. [Motallaei, Maryam; Shams-Rad, Shamim; Salehi-Abargouei, Amin] Shahid Sadoughi Univ Med Sci, Sch Publ Hlth, Dept Nutr, Yazd, Iran. [Ramezani-Jolfaie, Nahid; Mohammadi, Mohammad; Jahanlou, Alireza Shahab] Hormozgan Univ Med Sci, Sch Med, Dept Community Med, Bandar Abbas, Iran. C3 Shahid Sadoughi University of Medical Sciences; Shahid Sadoughi University of Medical Sciences RP Salehi-Abargouei, A (通讯作者)，Shahid Sadoughi Univ Med Sci, Sch Publ Hlth, Dept Nutr, Yazd, Iran. EM abargouei@gmail.com RI Ramezani-Jolfaie, Nahid/AAV-9979-2020; Salehi-Abargouei, Amin/C-9039-2011; mohammadi, saeed/AAK-7444-2021; motallaei, Maryam/ACD-0676-2022 OI Salehi-Abargouei, Amin/0000-0002-7580-6717; motallaei, Maryam/0000-0002-1871-5640 FU Nutrition and Food Security research center of Shahid Sadoughi University of Medical Sciences; Food Security research center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran FX We thank Nutrition and Food Security research center of Shahid Sadoughi University of Medical Sciences for their financial and scientific support. The present study was funded by Food Security research center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. 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Res. PD OCT PY 2021 VL 35 IS 10 BP 5427 EP 5439 DI 10.1002/ptr.7173 EA MAY 2021 PG 13 WC Chemistry, Medicinal; Pharmacology & Pharmacy WE Science Citation Index Expanded (SCI-EXPANDED) SC Pharmacology & Pharmacy GA WL6EZ UT WOS:000656333500001 PM 34060162 DA 2026-02-02 ER PT J AU Meir, AY Keller, M Bernhart, SH Rinott, E Tsaban, G Zelicha, H Kaplan, A Schwarzfuchs, D Shelef, I Gepner, Y Li, J Lin, YF Blüher, M Ceglarek, U Stumvoll, M Stadler, PF Stampfer, MJ Kovacs, P Liang, LM Shai, I AF Yaskolka Meir, Anat Keller, Maria Bernhart, Stephan H. Rinott, Ehud Tsaban, Gal Zelicha, Hila Kaplan, Alon Schwarzfuchs, Dan Shelef, Ilan Gepner, Yftach Li, Jun Lin, Yifei Blueher, Matthias Ceglarek, Uta Stumvoll, Michael Stadler, Peter F. Stampfer, Meir J. Kovacs, Peter Liang, Liming Shai, Iris TI Lifestyle weight-loss intervention may attenuate methylation aging: the CENTRAL MRI randomized controlled trial SO CLINICAL EPIGENETICS LA English DT Article DE Age prediction; Intrahepatic fat; DNA methylation; Aging; Weight loss ID EPIGENETIC CLOCK ANALYSIS; FATTY LIVER-DISEASE; ALL-CAUSE MORTALITY; DNA METHYLATION; VISCERAL FAT; AGE; CONSEQUENCES; EXERCISE; OBESITY; CANCER AB Background: DNA methylation age (mAge), a methylation biomarker for the aging process, might serve as a more accurate predictor of morbidity and aging status than chronological age. We evaluated the role of multiple factors, including fat deposition, cardiometabolic risk factors and lifestyle weight-loss intervention, on the deviation of mAge from chronological age (mAge deviation) or 18-month change in mAge (Delta mAge). In this sub-study of the CENTRAL magnetic resonance imaging weight-loss trial, we evaluated mAge by a validated 240-CpG-based prediction formula at baseline and after 18-month intervention of either low fat (LF) or mediterranean/low carbohydrate (MED/LC) diets. Results: Among 120 CENTRAL participants with abdominal obesity or dyslipidemia, mAge (mean +/- SD: 60.3 +/- 7.5 years) was higher than the chronological age (48.6 +/- 9.3 years) but strongly correlated (r = 0.93; p = 3.1 x 10(-53)). Participants in the lowest tertile of mAge deviation from their chronological age had significantly lower waist-circumference, visceral adipose tissue, intrahepatic fat (IHF) content, fasting-glucose and HOMA-IR, as compared with participants in the highest sex-specific residual tertile (p < 0.05 for all). IHF% remained associated with greater mAge deviation after further adjustments (beta = 0.23; p = 0.02). After 18-month weight-loss lifestyle intervention, mAge remained significantly correlated with chronological age (r = 0.94, p = 1.5 x 10(-55)). mAging occurred, with no difference between lifestyle intervention groups (Delta = 0.9 +/- 1.9 years in MED/LC vs. Delta = 1.3 +/- 1.9 years in LF; p = 0.2); however, we observed a mAging attenuation in successful weight losers (> 5% weight loss) vs. weight-loss failures (Delta = 0.6 years vs. Delta = 1.1 years; p = 0.04), and in participants who completed the trial with healthy liver fat content (< 5% IHF) vs. participants with fatty liver (Delta = 0.6 years vs. Delta = 1.8 years; p = 0.003). Overall, 18 months of weight-loss lifestyle intervention attenuated the mAging of the men, mainly the older, by 7.1 months than the expected (p < 0.05). Conclusions: Lifestyle weight-loss intervention may attenuate mAging. Deviation of mAge from chronological age might be related to body fat distribution and glycemic control and could indicate biological age, health status and the risk for premature cardiometabolic diseases. C1 [Yaskolka Meir, Anat; Rinott, Ehud; Tsaban, Gal; Zelicha, Hila; Kaplan, Alon; Shai, Iris] Ben Gurion Univ Negev, Dept Publ Hlth, Fac Hlth Sci, IL-84105 Beer Sheva, Israel. [Lin, Yifei; Stampfer, Meir J.; Liang, Liming] Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA. [Keller, Maria; Blueher, Matthias; Stumvoll, Michael] Univ Leipzig, Helmholtz Ctr Munich, Helmholtz Inst Metab Obes & Vasc Res HI MAG, D-04103 Leipzig, Germany. [Keller, Maria; Blueher, Matthias; Stumvoll, Michael] Univ Hosp Leipzig, D-04103 Leipzig, Germany. [Keller, Maria; Stumvoll, Michael; Kovacs, Peter] Univ Leipzig, Med Ctr, Med Dept Endocrinol Nephrol Rheumatol 3, D-04103 Leipzig, Germany. [Bernhart, Stephan H.] Univ Leipzig, Interdisciplinary Ctr Bioinformat, D-04107 Leipzig, Germany. [Bernhart, Stephan H.; Stadler, Peter F.] Univ Leipzig, Dept Comp Sci, Bioinformat Grp, D-04107 Leipzig, Germany. [Bernhart, Stephan H.] Univ Leipzig, LIFE Res Ctr Civilizat Dis, Transcriptome Bioinformat, D-04107 Leipzig, Germany. [Schwarzfuchs, Dan; Shelef, Ilan] Soroka Univ, Med Ctr, IL-84101 Beer Sheva, Israel. [Gepner, Yftach] Tel Aviv Univ, Sch Publ Hlth, Sackler Fac Med, Dept Epidemiol & Prevent Med, IL-6997801 Tel Aviv, Israel. [Gepner, Yftach] Tel Aviv Univ, Sylvan Adams Sports Inst, IL-6997801 Tel Aviv, Israel. [Li, Jun; Stampfer, Meir J.; Shai, Iris] Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA. [Ceglarek, Uta] Univ Leipzig, Inst Lab Med, Med Ctr, D-04103 Leipzig, Germany. [Stumvoll, Michael; Kovacs, Peter] Deutsch Zentrum Diabet Forsch, D-85764 Neuherberg, Germany. [Stadler, Peter F.] Univ Leipzig, German Ctr Integrat Biodivers Res iDiv, Competence Ctr Scalable Data Serv & Solut Dresden, D-04109 Leipzig, Germany. [Stadler, Peter F.] Univ Leipzig, Leipzig Res Ctr Civilizat Dis, D-04109 Leipzig, Germany. [Stadler, Peter F.] Max Planck Inst Math Sci, D-04103 Leipzig, Germany. [Stadler, Peter F.] Fraunhofer Inst Cell Therapy & Immunol, D-04103 Leipzig, Germany. [Stadler, Peter F.] Univ Vienna, Dept Theoret Chem, A-1090 Vienna, Austria. [Stadler, Peter F.] Univ Copenhagen, Ctr RNA Technol & Hlth, DK-1871 Frederiksberg, Denmark. [Stadler, Peter F.] Santa Fe Inst, Santa Fe, NM 87501 USA. [Stampfer, Meir J.] Brigham & Womens Hosp, Channing Div Network Med, Dept Med, Boston, MA 02115 USA. [Stampfer, Meir J.] Harvard Med Sch, Boston, MA 02115 USA. [Liang, Liming] Harvard TH Chan Sch Publ Hlth, Dept Biostat, Boston, MA 02115 USA. C3 Ben-Gurion University of the Negev; Harvard University; Harvard T.H. Chan School of Public Health; Helmholtz Association; Helmholtz-Center Munich - German Research Center for Environmental Health; Leipzig University; Leipzig University; Leipzig University; Leipzig University; Leipzig University; Leipzig University; Ben-Gurion University of the Negev; Soroka Medical Center; Tel Aviv University; Sackler Faculty of Medicine; Tel Aviv University; Harvard University; Harvard T.H. Chan School of Public Health; Leipzig University; Leipzig University; German Research Foundation (DFG); German Centre for Integrative Biodiversity Research (iDiv); Leipzig University; Max Planck Society; Fraunhofer Gesellschaft; Fraunhofer Germany; Fraunhofer Cell Therapy & Immunology; University of Vienna; University of Copenhagen; The Santa Fe Institute; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard University; Harvard Medical School; Harvard University; Harvard T.H. Chan School of Public Health RP Shai, I (通讯作者)，Ben Gurion Univ Negev, Dept Publ Hlth, Fac Hlth Sci, IL-84105 Beer Sheva, Israel.; Liang, LM (通讯作者)，Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA.; Shai, I (通讯作者)，Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA.; Liang, LM (通讯作者)，Harvard TH Chan Sch Publ Hlth, Dept Biostat, Boston, MA 02115 USA. EM lliang@hsph.harvard.edu; irish@bgu.ac.il RI Shai, Iris/HJO-8533-2023; Stadler, Peter F/L-7857-2015; Lin, LiAn/C-5819-2017; Lin, Yifei/ACO-6658-2022; Stumvoll, Michael/ABE-1121-2021; Keller, Maria/AAD-4877-2020; Ceglarek, Uta/GOE-5561-2022; Kovacs, Peter/KCK-1454-2024; Rinott, Ehud/KRO-7063-2024; Meir, Anat/AAK-7469-2021 OI Shai, Iris/0000-0001-9050-4605; Stadler, Peter F/0000-0002-5016-5191; , Stephan/0000-0002-5928-9449; Stumvoll, Michael/0000-0001-6225-8240; Zelicha, Hila/0000-0001-6989-2332; Kovacs, Peter/0000-0002-0290-5423; FU Free State of Saxony; Deutsche Forschungsgemeinschaft (DFG) [209933838-SFB 1052]; German Diabetes Association; Deutsches Zentrum fur Diabetesforschung; Israel Science Foundation (ISF); Israel Ministry of Science and Technology [3-13604]; Dr. Robert C. and Veronica Atkins Research Foundation FX This work has been supported by the Free State of Saxony and grants from the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation-Projektnummer 209933838-SFB 1052; B01, B03, B11, Z04), from the German Diabetes Association and Deutsches Zentrum fur Diabetesforschung. The CENTRAL RCT was supported by the Israel Science Foundation (ISF), Israel Ministry of Science and Technology (grant #3-13604) and the Dr. Robert C. and Veronica Atkins Research Foundation. 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Epigenetics PD MAR 4 PY 2021 VL 13 IS 1 AR 48 DI 10.1186/s13148-021-01038-0 PG 10 WC Oncology; Genetics & Heredity WE Science Citation Index Expanded (SCI-EXPANDED) SC Oncology; Genetics & Heredity GA QT4TD UT WOS:000626580700002 PM 33663610 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Kurotani, K Akter, S Kashino, I Goto, A Mizoue, T Noda, M Sasazuki, S Sawada, N Tsugane, S AF Kurotani, Kayo Akter, Shamima Kashino, Ikuko Goto, Atsushi Mizoue, Tetsuya Noda, Mitsuhiko Sasazuki, Shizuka Sawada, Norie Tsugane, Shoichiro CA Japan Public Hlth Ctr Based TI Quality of diet and mortality among Japanese men and women: Japan Public Health Center based prospective study SO BMJ-BRITISH MEDICAL JOURNAL LA English DT Article ID FOOD FREQUENCY QUESTIONNAIRE; FOLLOW-UP SURVEY; CORONARY-HEART-DISEASE; CARDIOVASCULAR-DISEASE; MEDITERRANEAN DIET; PROSPECTIVE COHORT; EATING INDEX; FATTY-ACIDS; JPHC; RISK AB OBJECTIVE To examine the association between adherence to the Japanese Food Guide Spinning Top and total and cause specific mortality. DESIGN Large scale population based prospective cohort study in Japan with follow-up for a median of 15 years. SETTING 11 public health centre areas across Japan. PARTICIPANTS 36 624 men and 42 970 women aged 45-75 who had no history of cancer, stroke, ischaemic heart disease, or chronic liver disease. MAIN OUTCOME MEASURES Deaths and causes of death identified with the residential registry and death certificates. RESULTS Higher scores on the food guide (better adherence) were associated with lower total mortality; the multivariable adjusted hazard ratios (95% confidence interval) of total mortality for the lowest through highest scores were 1.00, 0.92 (0.87 to 0.97), 0.88 (0.83 to 0.93), and 0.85 (0.79 to 0.91) (P< 0.001 for trend) and the multivariable adjusted hazard ratio associated with a 10 point increase in food guide scores was 0.93 (0.91 to 0.95; P< 0.001 for trend). This score was inversely associated with mortality from cardiovascular disease (hazard ratio associated with a 10 point increase 0.93, 0.89 to 0.98; P= 0.005 for trend) and particularly from cerebrovascular disease (0.89, 0.82 to 0.95; P= 0.002 for trend). There was some evidence, though not significant, of an inverse association for cancer mortality (0.96, 0.93 to 1.00; P= 0.053 for trend). CONCLUSION Closer adherence to Japanese dietary guidelines was associated with a lower risk of total mortality and mortality from cardiovascular disease, particularly from cerebrovascular disease, in Japanese adults. C1 [Kurotani, Kayo; Akter, Shamima; Kashino, Ikuko; Mizoue, Tetsuya] Natl Ctr Global Hlth & Med, Dept Epidemiol & Prevent, Ctr Clin Sci, Shinjuku Ku, 1-21-1 Toyama, Tokyo 1628655, Japan. [Goto, Atsushi] Tokyo Womens Med Univ, Dept Publ Hlth, Shinjuku Ku, 8-1 Kawadacho, Tokyo 1628666, Japan. [Noda, Mitsuhiko] Natl Ctr Global Hlth & Med, Dept Diabet Res, Shinjuku Ku, 1-21-1 Toyama, Tokyo 1628655, Japan. [Noda, Mitsuhiko] Saitama Med Univ, Dept Endocrinol & Diabet, 38 Moro Hongo, Moroyama, Saitama 3500495, Japan. [Sasazuki, Shizuka; Sawada, Norie; Tsugane, Shoichiro] Natl Canc Ctr, Epidemiol & Prevent Grp, Res Ctr Canc Prevent & Screening, Chuo Ku, 5-1-1 Tsukiji, Tokyo 1040045, Japan. C3 Japan Institute for Health Security (JIHS); National Center for Global Health & Medicine - Japan; Tokyo Women's Medical University; Japan Institute for Health Security (JIHS); National Center for Global Health & Medicine - Japan; Saitama Medical University; National Cancer Center - Japan RP Kurotani, K (通讯作者)，Natl Ctr Global Hlth & Med, Dept Epidemiol & Prevent, Ctr Clin Sci, Shinjuku Ku, 1-21-1 Toyama, Tokyo 1628655, Japan. EM kkurotani@ri.ncgm.go.jp RI KASHINO, IKUKO/AAS-4008-2020; Tsugane, Shoichiro/A-2424-2015; Goto, Atsushi/JMB-4492-2023; NODA, Mitsuhiko/W-3905-2019; Kurotani, Kayo/LBI-1517-2024 OI Goto, Atsushi/0000-0003-0669-654X; NODA, Mitsuhiko/0000-0003-0413-4631; Kurotani, Kayo/0000-0002-0109-6046 FU National Cancer Centre research and development fund [23-A-31[toku], 26-A-2]; Ministry of Health, Labour and Welfare of Japan; Japan Agency for Medical Research and Development [15ek0210021h0002]; JSPS KAKENHI [15H04779]; National Centre for Global Health and Medicine [26A-201]; Grants-in-Aid for Scientific Research [15H04779] Funding Source: KAKEN FX This study was supported by National Cancer Centre research and development fund (23-A-31[toku] and 26-A-2) (since 2011), a grant-in-aid for Cancer Research from the Ministry of Health, Labour and Welfare of Japan (from 1989 to 2010), Practical Research Project for Life-Style related Diseases including Cardiovascular Diseases and Diabetes Mellitus (15ek0210021h0002) from the Japan Agency for Medical Research and Development, JSPS KAKENHI Grant No 15H04779, and grants-in-aid for research from the National Centre for Global Health and Medicine (26A-201). 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Ricci, R. Aleo, E. Passi, S. Cataudella, S. TI Can enzymatic antioxidant defences in liver discriminate between wild and sea cage-reared Bluefin Tuna quality? SO AQUACULTURE LA English DT Article DE Thunnus thynnus; oxidative stress; antioxidant enzymes; glutathione peroxidase (GPx); seacage rearing ID GLUTATHIONE-PEROXIDASE; LIPID-PEROXIDATION; OXIDATIVE STRESS; OXIDIZED OIL; FISH; BIOCHEMISTRY; MECHANISMS; ENZYMES; L. AB Bluefin Tuna (Thunnus thynnus L.) is a fish species of high nutritional and commercial value that is increasingly farmed in the Mediterranean basin. Oxidative stress research in aquaculture is particularly important in the assessment of both the health of farmed fish and seafood quality. Reactive oxygen species (ROS) are able to start the lipid peroxiclation process which is potentially dangerous in fish, since they contain a high percentage of n-3 polyunsaturated fatty acids, in particular C20:5 n-3 and C22:6 n-3, which account for most of seafood's nutritional quality. The study of the antioxiclant system and how the various components interact to delay post-harvest lipid peroxidation covers both the improvement of quality and the extension of shelf life of the fresh tuna product. In this study, hepatic antioxidant enzymes (catalase-CAT, superoxide dismutase-SOD and glutathione peroxidase-GPx) and lipid peroxidation levels (TBARS) of wild and sea cage-reared tunas were investigated. The aim was to examine the possible oxidative stress state of wild tunas killed by different fishing methods, compared with reared specimens exposed to different periods of confinement but killed by the same method. No significant differences between wild specimens were found in relation to catching techniques. A significant depletion was observed in liver SOD activity in reared tunas (5.00 U/mg protein) in comparison with wild specimens (5.90 U/mg protein). No differences in liver CAT activity between wild and reared tunas were found. In reared specimens we observed an oxidative stress state indicated by an increase in GPx activity (104.70 U/mg protein and 0.83 U/mg protein in reared and wild tunas, respectively). A significantly higher liver lipid content was observed in reared tunas, but no significant differences between wild and reared tunas in terms of TBA reactive substances content were found (2.03 vs 2.02 micrornol TBARS/rng lipid). Our results suggest that the increased GPx activity leads to the suppression of lipid peroxiclation in liver of reared tunas. This is the first time that antioxiclant enzyme activities have been assayed in Bluefin Tuna and the stress state seems to be related to the diet of reared specimens rather than to their confinement, as indicated by the absence of differences in the antioxiclant activities related to the period of confinement. (c) 2008 Elsevier B. V. All rights reserved. C1 [Ferrante, I.; Cataudella, S.] Univ Roma Tor Vergata, Dept Biol, I-00133 Rome, Italy. [Ricci, R.; Aleo, E.; Passi, S.] Cell Ageing Ctr, IDI, I-00040 Rome, Italy. C3 University of Rome Tor Vergata; IRCCS Istituto Dermopatico dell'Immacolata (IDI) RP Ferrante, I (通讯作者)，Univ Roma Tor Vergata, Dept Biol, Via Ric Sci Snc, I-00133 Rome, Italy. 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Besides direct oxidative DNAdamage, reactive oxygen and nitrogen species can induce etheno ([epsilon])DNA adducts mainly via trans-4-hydroxy-2-nonenal, generated as the major aldehyde by lipid peroxidation (LPO) of [omega]-6 PUFAs. Patients with familial adenomatous polyposis (FAP) develop multiple colorectal adenomas. In affected tissues increased LPO could be triggered due to increased arachidonic acid metabolism as a result of elevated cyclooxygenases. Our studies demonstrated an increased [epsilon]DNA adduct level in affected colon epithelia of FAP patients. [epsilon]DNA adducts are promutagenic and can cause genomic instability that drives colorectal adenoma to malignancy. We have further investigated the potential chemopreventive properties of olive oil and its polyphenolic components. Mediterranean diet, of which olive oil is a major fatty acid source, has protective effects against human breast and colorectal cancers. Olive oil extracts and the newly identified lignan fractions showed high antioxidant capacity in vitro. As [epsilon]DNA adducts are biomarkers for oxidative stress and LPO induced DNA damage, they can verify the efficacy of newly identified antioxidants, e.g. from olive oil, as chemopreventive agents against colon carcinogenesis. C1 German Canc Res Ctr, Div Toxicol & Canc Risk Factors, D-69120 Heidelberg, Germany. C3 Helmholtz Association; German Cancer Research Center (DKFZ) RP Bartsch, H (通讯作者)，German Canc Res Ctr, Div Toxicol & Canc Risk Factors, Neuenheimer Feld 280, D-69120 Heidelberg, Germany. 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Chem. PD JUN PY 2002 VL 383 IS 6 BP 915 EP 921 DI 10.1515/BC.2002.098 PG 7 WC Biochemistry & Molecular Biology WE Science Citation Index Expanded (SCI-EXPANDED) SC Biochemistry & Molecular Biology GA 568YE UT WOS:000176571900005 PM 12222681 DA 2026-02-02 ER PT J AU Ben Khedher, MR Hammami, M Arch, JRS Hislop, DC Eze, D Wargent, ET Kepczynska, MA Zaibi, MS AF Ben Khedher, Mohamed R. Hammami, Mohamed Arch, Jonathan R. S. Hislop, David C. Eze, Dominic Wargent, Edward T. Kepczynska, Magorzata A. Zaibi, Mohamed S. TI Preventive effects of Salvia officinalis leaf extract on insulin resistance and inflammation in a model of high fat diet-induced obesity in mice that responds to rosiglitazone SO PEERJ LA English DT Article DE Fatty acids; Salvia officinalis; Inflammation; Insulin resistance; High fat diet ID ACTIVATED-RECEPTOR-GAMMA; ACID; DIFFERENTIATION; INDUCTION; PROSTATE; GLUCOSE; LEAVES; PPAR; SAGE AB Background. Salvia officinalis (sage) is a native plant to the Mediterranean region and has been used for a long time in traditional medicine for various diseases. We investigated possible anti-diabetic, anti-inflammatory and anti-obesity effects of sage methanol (MetOH) extract in a nutritional mouse model of obesity, inflammation and insulin resistance, as well as its effects on lipolysis and lipogenesis in 3T3-L1 cells. Methods. Diet-induced obese (DIO) mice were treated for five weeks with sage methanol extract (100 and 400 mg kg(-1)/day bid), or rosiglitazone (3 mg kg(-1)/day bid), as a positive control. Energy expenditure, food intake, body weight, fat mass, liver glycogen and lipid content were evaluated. Blood glucose, and plasma levels of insulin, lipids leptin and pro-and anti-inflammatory cytokines were measured throughout the experiment. The effects of sage MetOH extract on lipolysis and lipogenesis were tested in vitro in 3T3-L1 cells. Results. After two weeks of treatment, the lower dose of sage MetOH extract decreased blood glucose and plasma insulin levels during an oral glucose tolerance test (OGTT). An insulin tolerance test (ITT), performed at day 29 confirmed that sage improved insulin sensitivity. Groups treated with low dose sage and rosiglitazone showed very similar effects on OGTT and ITT. Sage also improved HOMA-IR, triglycerides and NEFA. Treatment with the low dose increased the plasma levels of the antiinflammatory cytokines IL-2, IL-4 and IL-10 and reduced the plasma level of the proinflammatory cytokines IL-12, TNF-alpha, and KC/GRO. The GC analysis revealed the presence of two PPARs agonist in sage MetOH extract. In vitro, the extract reduced in a dose-related manner the accumulation of lipid droplets; however no effect on lipolysis was observed. Conclusions. Sage MetOH extract at low dose exhibits similar effects to rosiglitazone. It improves insulin sensitivity, inhibits lipogenesis in adipocytes and reduces inflammation as judged by plasma cytokines. Sage presents an alternative to pharmaceuticals for the treatment of diabetes and associated inflammation. C1 [Ben Khedher, Mohamed R.; Hammami, Mohamed] Univ Monastir, Fac Med, Dept Biochem, Res Lab Nutr Funct Food & Vasc Hlth, Monastir, Tunisia. [Arch, Jonathan R. S.; Hislop, David C.; Wargent, Edward T.; Kepczynska, Magorzata A.; Zaibi, Mohamed S.] Univ Buckingham, Clore Lab, BITM, Buckingham, England. [Eze, Dominic] Univ Buckingham, Sch Med, Buckingham, England. C3 Universite de Monastir; University of Buckingham; University of Buckingham RP Zaibi, MS (通讯作者)，Univ Buckingham, Clore Lab, BITM, Buckingham, England. EM mohamed.zaibi@buckingham.ac.uk RI ; Zaibi, Mohamed/ABI-2395-2020; Dhia, Hammmami/LCS-1765-2024 OI Ben Khedher, Mohamed Raâfet/0000-0003-1527-7582; Wargent, Edward/0000-0002-8545-2430; FU Buckingham Institute for Translational Medicine (BITM); "Tunisian Ministry of Higher Education, Scientific Research and Technology'' FX This work was supported by Buckingham Institute for Translational Medicine (BITM), based in the Clore Laboratory at the University of Buckingham, United Kingdom. Part of this work has been supported by the "Tunisian Ministry of Higher Education, Scientific Research and Technology''. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. 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Method This is a cross-sectional real-world observational study. According to the inclusion and exclusion criteria, we studied 1377 patients with T2DM, grouped by fasting C-peptide and HOMA-IR. Blood samples were collected after fasting overnight. Logistic regression was used to analyse the relationship among fasting C-peptide, HOMA-IR, C2/C0 ratio (the ratio of 2 h postprandial C-peptide to fasting C-peptide), glycaemic control rate, and occurrence of diabetic complications. Restricted cubic spline (RCS) curves based on logistic regression were used to evaluate the relationship between C-peptide, glycaemic control rate, and diabetic kidney disease (DKD). Results Patients were subdivided according to their fasting C-peptide in 4 groups (Q1,Q2,Q3,Q4). Patients of group Q3 (1.71 <= C-peptide < 2.51 ng/ml) showed the lowest incidence of DKD, diabetic retinopathy (DR), and rate of insulin absorption as welll as higher glycaemic control rate. Logistic regression shows that the probability of reaching glycemic control increased with higher levels of C-peptide, compared with group Q1, after adjusting for age, gender, duration of diabetes, body mass index, systolic blood pressure, diastolic blood pressure, creatinine, low-density lipoprotein, triglyceride, total cholesterol, and high-density lipoprotein. RCS curve shows that, when C-peptide is <= 2.68 ng/ml, the incidence of not reaching glycaemic control decreases with increasing C-peptide. The possibility of not reaching glycaemic control decreased with increasing C2/C0, when C-peptide is >= 1.71 ng/ml. RCS curve shows that the relationship between C-peptide and DKD follows a U-style curve. When C-peptide is <2.84 ng/ml, the incidence of DKD decreased with increasing C-peptide. With the increase in the C2/C0 ratio, the incidence of DKD, DR, and fatty liver did not decrease. Conclusion When C-peptide is >= 1.71 and < 2.51 ng/ml, patients with T2DM had a higher glycemic control rate. Excessive C-peptide plays different roles in DKD and DR; C-peptide may promote the incidence of DKD but protects patients from DR. Higher C2/C0 ratio is important for reaching glycaemic control but cannot reduce the risk of DKD, DR, and fatty liver. C1 [Huang, Yajing; Liu, Chuanfeng; Zhou, Yue; Wang, Xiang; Cheng, Bingfei; Kui, Che; Wang, Yangang] Qingdao Univ, Dept Endocrinol, Affiliated Hosp, Qingdao 266003, Shandong, Peoples R China. [Wang, Yahao] Qingdao Univ, Med Coll, Qingdao, Peoples R China. C3 Qingdao University; Qingdao University RP Wang, YG (通讯作者)，Qingdao Univ, Dept Endocrinol, Affiliated Hosp, Qingdao 266003, Shandong, Peoples R China. EM wangyg1966@126.com FU National Science and Technology Development Agency [2020ZX09201-018] FX We thank the Free Statistics team for providing technical assistance and valuable tools for data analysis and visualisation. Our work was supported by grants from the National Science and Technology Development Agency (Project 2020ZX09201-018). 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Res. Rev. PD MAY PY 2022 VL 38 IS 4 AR e3514 DI 10.1002/dmrr.3514 EA JAN 2022 PG 11 WC Endocrinology & Metabolism WE Science Citation Index Expanded (SCI-EXPANDED) SC Endocrinology & Metabolism GA 0X3KV UT WOS:000741501300001 PM 34841643 DA 2026-02-02 ER PT J AU Yuguang, L Chang, Y Li, HW Li, FQ Zou, Q Liu, XL Chen, X Cui, JW AF Yuguang, Li Chang, Yu Li, Hongwei Li, Fangqi Zou, Qing Liu, Xiangliang Chen, Xiao Cui, Jiuwei TI Inflammation mediates the relationship between diet quality assessed by healthy eating index-2015 and metabolic syndrome SO FRONTIERS IN ENDOCRINOLOGY LA English DT Article DE healthy eating index; metabolic syndrome; mediation effect; NHANES; chronic inflammation ID STOP HYPERTENSION DASH; FATTY LIVER-DISEASE; MEDITERRANEAN DIET; MARKERS; METAANALYSIS; ASSOCIATION; FIBER; RISK AB Background: Metabolic syndrome is a cluster of metabolic disorders, including obesity, hypertension, hyperglycemia, and abnormal lipid levels. However, researches on the association between overall dietary quality measured by the Healthy Eating Index-2015 (HEI-2015) and the risk of metabolic syndrome is still lacking. Methods This study utilized data from four cycles (2011-2018) of the National Health and Nutrition Examination Survey (NHANES) database, including 17,582 participants. Logistic regression analysis was employed to explore the correlation between HEI and the risk of metabolic syndrome. Additionally, mediation analysis was conducted to examine the effects of Systemic Immune-Inflammation Index (SII) and serum uric acid as potential mediators between HEI and metabolic syndrome risk. Weighted quantile sum (WQS) regression evaluated the composite exposure impact of the 13 components of the HEI on metabolic syndrome, as well as the proportion of their weights. Results Higher dietary quality measured by HEI-2015 (at the 75th percentile) was negatively correlated with the risk of metabolic syndrome (OR=0.80, 95%CI=0.72-0.89, P=0.003). Higher SII and serum uric acid levels were identified as risk factors for metabolic syndrome (P for trend<0.001). Approximately 37.5% of the effect of HEI on metabolic syndrome occurrence was mediated by SII (Indirect effect=-0.002, 95%CI (-0.003,-0.001), Direct effect=-0.022, 95%CI (-0.0273,-0.015)). Additionally, 25% of the effect of HEI on metabolic syndrome occurrence was mediated by serum uric acid levels (Indirect effect=-0.006, 95%CI (-0.010,-0.012), Direct effect=-0.024, 95%CI (-0.041,-0.009)). WQS regression analysis revealed the highest weighted proportions for seafood and plant proteins (25.20%) and sodium (17.79%), while the weight for whole fruit was the lowest (0.25%). Conclusion Better dietary quality measured by HEI-2015 was associated with a lower likelihood of metabolic syndrome. 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Endocrinol. PD FEB 5 PY 2024 VL 15 AR 1293850 DI 10.3389/fendo.2024.1293850 PG 11 WC Endocrinology & Metabolism WE Science Citation Index Expanded (SCI-EXPANDED) SC Endocrinology & Metabolism GA IA2Q5 UT WOS:001163537700001 PM 38379861 OA Green Submitted, gold DA 2026-02-02 ER PT J AU Goldberg, DT Meir, AY Tsaban, G Rinott, E Kaplan, A Zelicha, H Klöting, N Ceglarek, U Iserman, B Shelef, I Rosen, P Blüher, M Stumvoll, M Etzion, O Stampfer, MJ Hu, FB Shai, I AF Goldberg, Dana T. Meir, Anat Yaskolka Tsaban, Gal Rinott, Ehud Kaplan, Alon Zelicha, Hila Kloeting, Nora Ceglarek, Uta Iserman, Berend Shelef, Ilan Rosen, Philip Blueher, Matthias Stumvoll, Michael Etzion, Ohad Stampfer, Meir J. Hu, Frank B. Shai, Iris TI Novel proteomic signatures may indicate MRI-assessed intrahepatic fat state and changes: The DIRECT PLUS clinical trial SO HEPATOLOGY LA English DT Article ID LIVER-DISEASE; STEATOHEPATITIS; PROGRESSION; BIOPSIES AB Background and Aims: We demonstrated in the randomized 18-month DIRECT PLUS trial (n = 294) that a Mediterranean (MED) diet, supplemented with polyphenol-rich Mankai duckweed, green tea, and walnuts and restricted in red/processed meat, caused substantial intrahepatic fat (IHF%) loss compared with 2 other healthy diets, reducing NAFLD by half, regardless of similar weight loss. Here, we investigated the baseline proteomic profile associated with IHF% and the changes in proteomics associated with IHF% changes induced by lifestyle intervention. Approach and Results: We calculated IHF% by proton magnetic resonance spectroscopy (normal IHF% <5% and abnormal IHF% >= 5%). We assayed baseline and 18-month samples for 95 proteomic biomarkers.Participants (age = 51.3 10.8 y; 89% men; and body mass index = 31.3 +/- 3.9 kg/m(2)) had an 89.8% 18-month retention rate; 83% had eligible follow-up proteomics measurements, and 78% had follow-up proton magnetic resonance spectroscopy. At baseline, 39 candidate proteins were significantly associated with IHF% (false discovery rate <0.05), mostly related to immune function pathways (eg, hydroxyacid oxidase 1). An IHF% prediction based on the DIRECT PLUS by combined model (R-2 = 0.47, root mean square error = 1.05) successfully predicted IHF% (R-2 = 0.53) during testing and was stronger than separately inputting proteins/traditional markers (R-2 = 0.43/0.44). The 18-month lifestyle intervention induced changes in 18 of the 39 candidate proteins, which were significantly associated with IHF% change, with proteins related to metabolism, extracellular matrix remodeling, and immune function pathways. Thrombospondin-2 protein change was higher in the green-MED compared to the MED group, beyond weight and IHF% loss (p = 0.01). Protein principal component analysis revealed differences in the third principal component time distinct interactions across abnormal/normal IHF% trajectory combinations; p < 0.05 for all). Conclusions: Our findings suggest novel proteomic signatures that may indicate MRI-assessed IHF state and changes during lifestyle intervention. Specifically, carbonic anhydrase 5A, hydroxyacid oxidase 1, and thrombospondin-2 protein changes are independently associated with IHF% change, and thrombospondin-2 protein change is greater in the green-MED/high polyphenols diet. C1 [Goldberg, Dana T.; Meir, Anat Yaskolka; Tsaban, Gal; Rinott, Ehud; Kaplan, Alon; Zelicha, Hila; Shai, Iris] Ben Gurion Univ Negev, Dept Epidemiol Biostat & Community Hlth Sci, Hlth & Nutr Innovat Int Res Ctr, Fac Hlth Sci,Sch Publ Hlth, POB 653, IL-84105 Beer Sheva, Israel. [Meir, Anat Yaskolka; Stampfer, Meir J.; Hu, Frank B.] Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, 655 Huntington Ave,Bldg 2,Room 202, Boston, MA 02115 USA. [Kloeting, Nora; Ceglarek, Uta; Iserman, Berend; Blueher, Matthias; Stumvoll, Michael; Shai, Iris] Univ Leipzig, Dept Med, Leipzig, Germany. [Ceglarek, Uta; Iserman, Berend] Univ Leipzig Med Ctr, Inst Lab Med Clin Chem & Mol Diagnost, Leipzig, Germany. [Shelef, Ilan; Rosen, Philip] Ben Gurion Univ Negev, Soroka Univ Med Ctr, Dept Diagnost Imaging, Beer Sheva, Israel. [Blueher, Matthias; Stumvoll, Michael] Univ Leipzig, Helmholtz Zentrum Munchen, Helmholtz Inst Metab Obes & Vasc Res HI MAG, Leipzig, Germany. [Blueher, Matthias; Stumvoll, Michael] Univ Hosp Leipzig, Leipzig, Germany. [Etzion, Ohad] Soroka Univ Med Ctr, Dept Gastroenterol & Liver Dis, Beer Sheva, Israel. [Stampfer, Meir J.; Hu, Frank B.; Shai, Iris] Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA. [Stampfer, Meir J.; Hu, Frank B.] Brigham & Womens Hosp, Channing Div Network Med, Dept Med, Boston, MA USA. [Stampfer, Meir J.; Hu, Frank B.] Harvard Med Sch, Boston, MA USA. C3 Ben-Gurion University of the Negev; Harvard University; Harvard T.H. Chan School of Public Health; Leipzig University; Leipzig University; Ben-Gurion University of the Negev; Soroka Medical Center; Helmholtz Association; Helmholtz-Center Munich - German Research Center for Environmental Health; Leipzig University; Leipzig University; Ben-Gurion University of the Negev; Soroka Medical Center; Harvard University; Harvard T.H. Chan School of Public Health; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard University; Harvard Medical School RP Shai, I (通讯作者)，Ben Gurion Univ Negev, Dept Epidemiol Biostat & Community Hlth Sci, Hlth & Nutr Innovat Int Res Ctr, Fac Hlth Sci,Sch Publ Hlth, POB 653, IL-84105 Beer Sheva, Israel.; Meir, AY (通讯作者)，Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, 655 Huntington Ave,Bldg 2,Room 202, Boston, MA 02115 USA. EM dago@post.bgu.ac.il; ayaskolkameir@hsph.harvard.edu; gtsaban@gmail.com; ehudri@post.bgu.ac.il; alonkaplan47@gmail.com; hila.zelicha@gmail.com; nora.kloeting@medizin.uni-leipzig.de; uta.ceglarek@medizin.uni-leipzig.de; Berend.Isermann@medizin.uni-leipzig.de; shelef@bgu.ac.il; philipr@clalit.org.il; matthias.blueher@medizin.uni-leipzig.de; Michael.Stumvoll@medizin.uni-leipzig.de; OhedEt@clalit.org.il; stampfer@hsph.harvard.edu; frank.hu@channing.harvard.edu; irish@bgu.ac.il RI ; Goldberg, Dana Tamar/LTZ-8424-2024; Klöting, Nora/PAU-4795-2025; Rinott, Ehud/KRO-7063-2024; Ceglarek, Uta/GOE-5561-2022; Meir, Anat/AAK-7469-2021; Shai, Iris/HJO-8533-2023; Hu, Frank/C-1919-2013; Stumvoll, Michael/ABE-1121-2021 OI Zelicha, Hila/0000-0001-6989-2332; Goldberg, Dana Tamar/0000-0002-8878-5695; Klöting, Nora/0000-0002-7625-7254; Shai, Iris/0000-0001-9050-4605; FU German Research Foundation (DFG) [209933838-SFB 1052]; Israel Ministry of Health grant [87472511]; Israel Ministry of Science and Technology grant [3-13604]; California Walnuts Commission; Council for Higher Education-Zuckerman FX This work was supported by grants from the German Research Foundation (DFG) (German Research Foundation-project number 209933838-SFB 1052; B11), Israel Ministry of Health grant 87472511 (to Iris Shai); Israel Ministry of Science and Technology grant 3-13604 (to Iris Shai); and the California Walnuts Commission (to Iris Shai). Anat Yaskolka Meir is supported by the Council for Higher Education-Zuckerman support program for outstanding postdoctoral female researchers. These information, content, and conclusions are those of the authors and should not be construed as the official position or policy of, nor should any endorsements be inferred by the funding agencies. 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Design: Cross-sectional study consisting of a health check including anthropometric measures and food questionnaires as well as analysis of biochemical parameters related to MetS. The diagnostic criteria of the International Diabetes Federation (IDF) were used for diagnosis of MetS. Setting: Four centres in continental (Virovitica and Zagreb) and Adriatic coast (Split and Omis.) regions of Croatia. Subjects: Free-living elderly persons aged 70-90 years (n 320). Results: Significantly lower MetS prevalence was found among participants from small urban centres compared with those from large urban centres (59.1% v. 69.6%; P = 0.051). Participants without MetS consumed wine more frequently (P = 0.05) than those with MetS. Compared with their peers with HDL cholesterol (HDL-C) <1.03 mmol/l, more male participants with HDL-C >= 1.03 mmol/l consumed wine (P = 0.04) or pelagic fish (P = 0.03). The prevalence of participants with TAG >= 1.7 mmol/l was higher in wine non-consumers (P = 0.05) than in wine consumers. Multivariate analysis with age and gender as covariates showed a significant inverse association of wine consumption with total cholesterol (P < 0.001), a positive association with HDL-C (P < 0.001) and a marginally inverse association with TAG (P = 0.06). In the male population, alkaline phosphatase and g-glutamyl transferase activities were higher in participants with MetS (P < 0.05). Conclusions: High MetS prevalence was observed in an elderly Croatian population. Data showed that moderate consumption of wine and/or pelagic fish has a protective role against MetS in the population studied. C1 [Corovic, Naima; Pizent, Alica; Jurasovic, Jasna; Pavlovic, Mladen] Inst Med Res & Occupat Hlth, HR-10000 Zagreb, Croatia. [Pasalic, Daria] Univ Zagreb, Sch Med, Dept Chem & Biochem, Zagreb 41001, Croatia. [Dodig, Slavica] Srebrnjak Childrens Hosp, Minist Hlth & Social Welf, Reference Ctr Clin Paediat Allergy, Zagreb, Croatia. C3 Institute for Medical Research & Occupational Health (IMROH); University of Zagreb RP Pavlovic, M (通讯作者)，Inst Med Res & Occupat Hlth, Ksaverska C 2, HR-10000 Zagreb, Croatia. EM mpavlov@imi.hr RI Pasalic, Daria/AAC-8025-2020; Jurasovic, Jasna/ABD-9777-2020; Pizent, Alica/AAY-8363-2020 OI Jurasovic, Jasna/0000-0002-3183-7327; Pizent, Alica/0000-0003-0216-0166 FU Croatian Ministry of Science, Education and Sport [022-0222411-2407, 277-2770966-0965, 108-1080316-0298, 022-0222411-2408] FX Sources of funding: The work was supported by Project Grants 022-0222411-2407, 277-2770966-0965, 108-1080316-0298 and 022-0222411-2408 of the Croatian Ministry of Science, Education and Sport. Conflict of interest declaration: There are no conflicts of interest. Authorship responsibilities: The study was designed by M. P. D. P. and M. P. wrote the manuscript. M. P. and N.C. were responsible for the medical check-ups and D. P., S. D. and J.J. for the biochemical analyses. D. P. and A. P. supervised the statistical analysis. D. P. was responsible for review and revision of the manuscript, with assistance from M.P. and J.J. 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PD SEP PY 2011 VL 14 IS 9 BP 1650 EP 1657 DI 10.1017/S1368980010003265 PG 8 WC Public, Environmental & Occupational Health; Nutrition & Dietetics WE Science Citation Index Expanded (SCI-EXPANDED) SC Public, Environmental & Occupational Health; Nutrition & Dietetics GA 811LN UT WOS:000294212000019 PM 21138612 OA Bronze DA 2026-02-02 ER PT J AU Bertoli, S Leone, A Vignati, L Spadafranca, A Bedogni, G Vanzulli, A Rodeschini, E Battezzati, A AF Bertoli, Simona Leone, Alessandro Vignati, Laila Spadafranca, Angela Bedogni, Giorgio Vanzulli, Angelo Rodeschini, Elena Battezzati, Alberto TI Metabolic correlates of subcutaneous and visceral abdominal fat measured by ultrasonography: a comparison with waist circumference SO NUTRITION JOURNAL LA English DT Article DE Epidemiology; Cross-sectional study; Visceral fat; Subcutaneous fat; Waist circumference; Ultrasonography; Metabolic syndrome; Liver enzymes; Uric acid ID SERUM URIC-ACID; ADIPOSE-TISSUE; RISK-FACTORS; LIVER-DISEASE; CARDIOVASCULAR-DISEASE; MEDITERRANEAN DIET; ASSOCIATION; ULTRASOUND; THICKNESS; WOMEN AB Background: The relative contribution of visceral (VAT) and subcutaneous (SAT) adipose tissue to cardiometabolic disease is controversial. The aim of this study was to evaluate whether dissecting abdominal fat in VAT and SAT using US may detect stronger and more specific association with MS, MS components, hyperuricemia and altered liver enzymes compared to waist circumference. Methods: We performed a cross-sectional study on 2414 subjects aged 18 to 66 years (71 % women) followed at the International Center for the Assessment of Nutritional Status (ICANS, Milan, Italy). VAT and SAT were measured using ultrasonography. Multivariable logistic regression controlling for age and gender was used to evaluate the association of the parameters of interest (waist circumference (WC), VAT, SAT and VAT + SAT) with the MS (international harmonized definition), its components (high triglycerides, low HDL, high blood pressure, high glucose), high uric acid (>= 7 mg/dl), high alanine transaminase (ALT, >= 30 U/l) and high gamma-glutamyl-transferase (GGT, >= 30 U/l). Results: VAT was independently associated with all the outcomes of interest, while SAT was independently associated with MS and only with high blood pressure and high ALT when we considered the single parameters of MS and NAFLD. VAT had the strongest association with high triglycerides, high ALT and high GGT. The VAT + SAT association had the strongest association with MS. WC had the strongest association with low HDL and high blood pressure. VAT and WC were similarly associated to high glucose and high uric acid. Conclusion: US-determined VAT and SAT are both independently associated with MS. Moreover, to our knowledge, we are the first to show that VAT, being associated to all of the MS components in addition to hyperuricemia and altered liver enzymes, performs equally or better than WC except for high blood pressure and low HDL. C1 [Bertoli, Simona; Leone, Alessandro; Vignati, Laila; Spadafranca, Angela; Bedogni, Giorgio; Rodeschini, Elena; Battezzati, Alberto] Univ Milan, Int Ctr Assessment Nutr Status, Dept Food Environm & Nutr Sci DEFENS, I-20133 Milan, Italy. [Vanzulli, Angelo] Osped Niguarda Ca Granda, Div Radiol, Milan, Italy. C3 University of Milan; IRCCS Ca Granda Ospedale Maggiore Policlinico; Ospedale Niguarda Ca' Granda RP Bertoli, S (通讯作者)，Univ Milan, Int Ctr Assessment Nutr Status, Dept Food Environm & Nutr Sci DEFENS, Via Botticelli 21, I-20133 Milan, Italy. EM simona.bertoli@unimi.it RI BATTEZZATI, ALBERTO/J-1717-2012; Bedogni, Giorgio/K-1911-2018; LEONE, ALESSANO/F-4769-2015; Bertoli, Simona/K-2805-2018; Vanzulli, Angelo/X-4175-2019 OI BATTEZZATI, ALBERTO/0000-0003-4134-0557; Bedogni, Giorgio/0000-0002-1495-9306; LEONE, ALESSANO/0000-0001-8063-8490; Vanzulli, Angelo/0000-0002-2452-3370 FU ICANS internal grants FX This study was supported by ICANS internal grants. 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Elango, Rajavel CA PRECISE Conceptual Framework Worki TI Maternal nutritional risk factors for pre-eclampsia incidence: findings from a narrative scoping review SO REPRODUCTIVE HEALTH LA English DT Review ID PREGNANCY-INDUCED HYPERTENSION; POLYUNSATURATED FATTY-ACIDS; VITAMIN-D DEFICIENCY; CALCIUM INTAKE; OXIDATIVE STRESS; PARATHYROID-HORMONE; MEDITERRANEAN DIET; METABOLIC SYNDROME; PRETERM DELIVERY; ZINC LEVEL AB Background: Pre-eclampsia is a leading cause of maternal mortality and morbidity that involves pregnancy-related stressors on the maternal cardiovascular and metabolic systems. As nutrition is important to support optimal development of the placenta and for the developing fetus, maternal diets may play a role in preventing pre-eclampsia. The purpose of this scoping review is to map the maternal nutritional deficiencies and imbalances associated with pre-eclampsia incidence and discuss evidence consistency and linkages with current understandings of the etiology of pre-eclampsia. Methods: A narrative scoping review was conducted to provide a descriptive account of available research, summarize research findings and identify gaps in the evidence base. Relevant observational studies and reviews of observational studies were identified in an iterative two-stage process first involving electronic database searches then more sensitive searches as familiarity with the literature increased. Results were considered in terms of their consistency of evidence, effect sizes and biological plausibility. Results: The review found evidence for associations between nutritional inadequacies and a greater risk of pre-eclampsia. These associations were most likely mediated through oxidative stress, inflammation, maternal endothelial dysfunction and blood pressure in the pathophysiology of pre-eclampsia. Maternal nutritional risk factors for pre-eclampsia incidence with the strongest consistency, effect and biological plausibility include vitamin C and its potential relationship with iron status, vitamin D (both on its own and combined with calcium and magnesium), and healthy dietary patterns featuring high consumption of fruits, vegetables, whole grains, fish, seafood and monounsaturated vegetable oils. Foods high in added sugar, such as sugary drinks, were associated with increased risk of pre-eclampsia incidence. Conclusion: A growing body of literature highlights the involvement of maternal dietary factors in the development of pre-eclampsia. Our review findings support the need for further investigation into potential interactions between dietary factors and consideration of nutritional homeostasis and healthy dietary patterns. Further research is recommended to explore gestational age, potential non-linear relationships, dietary diversity and social, cultural contexts of food and meals. Plain language summary: Pre-eclampsia is a condition of high blood pressure during the second half of pregnancy with signs of damage to another organ system, often the liver and kidneys. It is a serious and potentially deadly disease and is the second top cause of deaths related to pregnancy and childbirth globally. Though the exact cause of pre-eclampsia is unclear, researchers have discovered that pre-eclampsia develops through abnormal development of the placenta, which is the interface between the growing baby and the mother in the womb. The placenta helps to transfer nutrients, oxygen and waste between the mother and fetus. Nutrition has important roles to play in the development of the placenta and certain vitamins and minerals have clinical properties that may help prevent pre-eclampsia. We conducted a review to summarize observational studies on maternal nutritional risk factors associated with the development of pre-eclampsia. Promising maternal dietary factors that fit with current understandings of how pre-eclampsia develops include vitamin C and its potential relationship with iron, calcium and vitamin D. Healthy dietary patterns with high consumption of fruits, vegetables, whole grains, fish and seafood and monounsaturated vegetable oils are likely beneficial. Foods high in added sugar, such as sugary drinks, may be linked to higher rates of developing pre-eclampsia. Instead of focusing on single nutrient deficiencies, our findings support a broader approach to explore interrelationships between dietary factors and balanced healthy dietary intake for the prevention of pre-eclampsia. C1 [Kinshella, Mai-Lei Woo; Omar, Shazmeen; Scherbinsky, Kerri; Vidler, Marianne; Magee, Laura A.; von Dadelszen, Peter] BC Childrens & Womens Hosp, Dept Obstet & Gynaecol, Vancouver, BC, Canada. [Kinshella, Mai-Lei Woo; Omar, Shazmeen; Scherbinsky, Kerri; Vidler, Marianne; Magee, Laura A.; von Dadelszen, Peter] Univ British Columbia, Vancouver, BC, Canada. [Scherbinsky, Kerri; Elango, Rajavel] Univ British Columbia, Dept Pediat, BC Childrens & Womens Hosp, Rm170,950 West 28th Ave, Vancouver, BC, Canada. [Magee, Laura A.; von Dadelszen, Peter; Moore, Sophie E.] Kings Coll London, Dept Women & Childrens Hlth, London, England. [Moore, Sophie E.] Sch Hyg & Trop Med, MRC Unit Gambia London, Fajara, Gambia. [Elango, Rajavel] Univ British Columbia, Sch Populat & Publ Hlth, Vancouver, BC, Canada. C3 University of British Columbia; University of British Columbia; University of British Columbia; University of London; King's College London; University of British Columbia RP Elango, R (通讯作者)，Univ British Columbia, Dept Pediat, BC Childrens & Womens Hosp, Rm170,950 West 28th Ave, Vancouver, BC, Canada. EM relango@bcchr.ubc.ca RI von Dadelszen, Peter/AAP-7480-2021; Kinshella, Mai-Lei Woo/AAA-8117-2022 OI von Dadelszen, Peter/0000-0003-4136-3070; Kinshella, Mai-Lei Woo/0000-0001-5846-3014; Magee, Laura/0000-0002-1355-610X; Scherbinsky, Kerri/0000-0003-2311-808X; Moore, Sophie/0000-0003-1650-3238; Elango, Rajavel/0000-0002-9380-1725 FU UK Research and Innovation Grand Challenges Research Fund GROW Award scheme [MR/P027938/1]; Vanier Canada Graduate Scholarship - Government of Canada through the Canadian Institutes of Health Research (CIHR); Canadian Institute of Health Research [FRN 10321]; Medical Research Council [MR/P012019/1] Funding Source: researchfish FX The PRECISE Network is funded by the UK Research and Innovation Grand Challenges Research Fund GROW Award scheme (Grant number: MR/P027938/1). 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